microsomal triglyceride transfer protein

Summary

Gene Symbol: microsomal triglyceride transfer protein
Description: microsomal triglyceride transfer protein
Alias: ABL, MTP, microsomal triglyceride transfer protein large subunit, microsomal triglyceride transfer protein (large polypeptide, 88kDa)
Species: human

Top Publications

  1. Hagan D, Kienzle B, Jamil H, Hariharan N. Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. J Biol Chem. 1994;269:28737-44 pubmed
    In order to characterize the molecular mechanisms that dictate microsomal triglyceride transfer protein (MTP) gene transcription in human and hamster, two species with similar plasma lipoprotein profiles, the MTP gene promoters were ..
  2. Petit J, Masson D, Minello A, Duvillard L, Galland F, Verges B, et al. Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients. Mol Genet Metab. 2006;88:196-8 pubmed
    It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients...
  3. Beekman M, Blauw G, Houwing Duistermaat J, Brandt B, Westendorp R, Slagboom P. Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J Gerontol A Biol Sci Med Sci. 2006;61:355-62 pubmed
    ..was linked to exceptional human longevity, and a haplotype of the positional candidate microsomal transfer protein (MTP) gene was associated to the phenotype in U.S. Caucasians...
  4. Rubin D, Helwig U, Pfeuffer M, Schreiber S, Boeing H, Fisher E, et al. A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels. J Hum Genet. 2006;51:567-74 pubmed
    The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B-containing lipoproteins...
  5. Bathum L, Christiansen L, Tan Q, Vaupel J, Jeune B, Christensen K. No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians. Eur J Hum Genet. 2005;13:1154-8 pubmed
  6. Nebel A, Croucher P, Stiegeler R, Nikolaus S, Krawczak M, Schreiber S. No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc Natl Acad Sci U S A. 2005;102:7906-9 pubmed
    ..S. Caucasians [long-lived individuals (LLI)] identified a SNP haplotype of the microsomal triglyceride transfer protein (MTP, 4q25) that was underrepresented among LLI when compared with younger controls...
  7. Garcia Garcia A, González C, Real J, Martín de Llano J, Gonzalez Albert V, Civera M, et al. Influence of microsomal triglyceride transfer protein promoter polymorphism -493 GT on fasting plasma triglyceride values and interaction with treatment response to atorvastatin in subjects with heterozygous familial hypercholesterolaemia. Pharmacogenet Genomics. 2005;15:211-8 pubmed
    ..Microsomal triglyceride (TG) transfer protein (MTP) is a protein involved in lipid metabolism...
  8. Gambino R, Cassader M, Pagano G, Durazzo M, Musso G. Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?. Hepatology. 2007;45:1097-107 pubmed
    ..b>Microsomal triglyceride transfer protein (MTP) -493 G/T polymorphism modulates circulating lipid and lipoprotein levels in different ..
  9. Böhme M, Grallert H, Fischer A, Gieger C, Nitz I, Heid I, et al. MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort. Mol Genet Metab. 2008;95:229-32 pubmed publisher
    The microsomal triglyceride transfer protein (MTTP) is a key regulator in the assembly and secretion of chylomicrons and very low density lipoprotein (VLDL) in the intestine and in liver...

More Information

Publications85

  1. Wetterau J, Aggerbeck L, Bouma M, Eisenberg C, Munck A, Hermier M, et al. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science. 1992;258:999-1001 pubmed
    ..The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from the liver and intestine, has ..
  2. Peng X, Wu Y, Lu Q, Hu Z, Lin X. MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population. Liver Int. 2014;34:118-28 pubmed publisher
    The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (ApoB)-containing lipoproteins from the liver and intestine...
  3. Geesaman B, Benson E, Brewster S, Kunkel L, Blanche H, Thomas G, et al. Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. Proc Natl Acad Sci U S A. 2003;100:14115-20 pubmed
    ..This study provides proof of concept for the feasibility of using the genomes of LLI to identify genes impacting longevity. ..
  4. Chen S, Tan K, Lam K. Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions. Atherosclerosis. 2003;167:287-92 pubmed
    Genetic variation in the microsomal triglyceride transfer protein (MTP) affects the secretion pattern and plasma concentration of apolipoprotein (aopB)-containing lipoproteins and a common functional -493 G/T polymorphism has been ..
  5. Yang Z, Zhang X, Kong X, Zhang D, Zhang S, Jiang J, et al. Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients. World J Gastroenterol. 2008;14:5454-60 pubmed
    To identify the two polymorphisms of microsomal triglyceride transfer protein (MTP) gene in the Chinese population and to explore their correlation with both hepatitis B virus (HBV) self-limited infection and persistent infection...
  6. Zampino R, Ingrosso D, Durante Mangoni E, Capasso R, Tripodi M, Restivo L, et al. Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients. J Viral Hepat. 2008;15:740-6 pubmed publisher
    A) A reduced activity of microsomal triglyceride transfer protein (MTP), a key enzyme of assembly/secretion of lipoproteins, is related to HCV steatosis. Host genetic background may influence development of steatosis...
  7. Zak A, Jachymova M, Tvrzicka E, Vecka M, Duffková L, Zeman M, et al. The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress. J Nutr Biochem. 2008;19:634-41 pubmed publisher
    The aim of this study was to investigate the effect of the microsomal triglyceride transfer protein (MTP) -493G/T polymorphism on clinical and biochemical parameters in relation to the presence of metabolic syndrome (MS)...
  8. Berthier M, Houde A, Paradis A, Couture P, Gaudet D, Despres J, et al. Molecular screening of the microsomal triglyceride transfer protein: association between polymorphisms and both abdominal obesity and plasma apolipoprotein B concentration. J Hum Genet. 2004;49:684-90 pubmed
    b>Microsomal triglyceride transfer protein (MTP) plays a critical role in the assembly of lipoproteins...
  9. Musso G, Gambino R, Cassader M. Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis. J Nutr Biochem. 2010;21:834-40 pubmed publisher
    ..b>Microsomal triglyceride transfer protein (MTP) polymorphism modulates lipoprotein metabolism in the general population and liver disease ..
  10. El Koofy N, El Karaksy H, Mandour I, Anwar G, El Raziky M, El Hennawy A. Genetic polymorphisms in non-alcoholic fatty liver disease in obese Egyptian children. Saudi J Gastroenterol. 2011;17:265-70 pubmed publisher
    Polymorphisms in the promoter of microsomal triglyceride transfer protein (MTP) lead to decreased MTP transcription, less export of triglyceride from hepatocytes, and greater intracellular triglyceride accumulation...
  11. Schgoer W, Eller P, Mueller T, Tancevski I, Wehinger A, Ulmer H, et al. The MTP -493TT genotype is associated with peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) Study. Clin Biochem. 2008;41:712-6 pubmed publisher
    b>Microsomal triglyceride transfer protein (MTP) transfers lipids into apoprotein B-containing lipoproteins for secretion from liver, intestine, and heart...
  12. Rubin D, Schneider Muntau A, Klapper M, Nitz I, Helwig U, Folsch U, et al. Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene. Hum Mutat. 2008;29:123-9 pubmed
    The microsomal triglyceride transfer protein (MTTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from the intestine and liver...
  13. Mirandola S, Osterreicher C, Marcolongo M, Datz C, Aigner E, Schlabrakowski A, et al. Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C. Liver Int. 2009;29:557-65 pubmed publisher
    Hepatic steatosis may promote progression of chronic hepatitis C (CHC). Microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of ApoB lipoprotein and is implicated in hepatitis C virus (HCV)-related ..
  14. Okumura K, Imamura A, Murakami R, Takahashi R, Cheng X, Numaguchi Y, et al. Microsomal triglyceride transfer protein gene polymorphism strongly influences circulating malondialdehyde-modified low-density lipoprotein. Metabolism. 2009;58:1306-11 pubmed publisher
    b>Microsomal triglyceride transfer protein (MTP) plays a critical role in the assembly of lipoproteins...
  15. Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, et al. Lack of replication of genetic associations with human longevity. Biogerontology. 2008;9:85-92 pubmed
    ..Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (rs2542052), Microsomal Transfer Protein (MTP) -493G/T (rs2866164) and apolipoprotein E (APOE) epsilon2 and epsilon4 isoforms, (rs7412 and rs429358) haplotypes ..
  16. Lundahl B, Skoglund Andersson C, Caslake M, Bedford D, Stewart P, Hamsten A, et al. Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. Am J Physiol Endocrinol Metab. 2006;290:E739-45 pubmed
    The microsomal triglyceride transfer protein (MTP) is essential for the synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins...
  17. Yamada Y, Ando F, Shimokata H. Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women. Int J Mol Med. 2006;17:83-8 pubmed
    Genetic variants of the microsomal triglyceride transfer protein (MTP) have been associated with the serum concentration of low density lipoprotein-cholesterol, predisposition to coronary heart disease, or longevity...
  18. Sposito A, Gonbert S, Turpin G, Chapman M, Thillet J. Common polymorphism in the MTP promoter attenuates the dyslipidemic and proatherogenic effects of excess body weight. Arterioscler Thromb Vasc Biol. 2004;24:e143 pubmed
  19. Sharp D, Blinderman L, Combs K, Kienzle B, Ricci B, Wager Smith K, et al. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature. 1993;365:65-9 pubmed
    The microsomal triglyceride transfer protein (MTP), which catalyses the transport of triglyceride, cholesteryl ester and phospholipid between phospholipid surfaces, is a heterodimer composed of the multifunctional protein, protein ..
  20. Lundahl B, Hamsten A, Karpe F. Postprandial plasma ApoB-48 levels are influenced by a polymorphism in the promoter of the microsomal triglyceride transfer protein gene. Arterioscler Thromb Vasc Biol. 2002;22:289-93 pubmed
    The microsomal triglyceride transfer protein (MTP) plays a key role in the secretion of apolipoprotein B (apoB)-containing lipoproteins...
  21. St Pierre J, Lemieux I, Miller Felix I, Prud homme D, Bergeron J, Gaudet D, et al. Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. Atherosclerosis. 2002;160:317-24 pubmed
    ..A functional, non-coding microsomal triglyceride transfer protein (MTP) -493G/T polymorphism of the microsomal triglyceride transfer protein gene has been related ..
  22. Hashemi M, Hoseini H, Yaghmaei P, Moazeni Roodi A, Bahari A, Hashemzehi N, et al. Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease. DNA Cell Biol. 2011;30:569-75 pubmed publisher
    ..ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in NAFLD...
  23. Ledmyr H, Karpe F, Lundahl B, McKinnon M, Skoglund Andersson C, Ehrenborg E. Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index. J Lipid Res. 2002;43:51-8 pubmed
    The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from liver and intestine...
  24. Aminoff A, Ledmyr H, Thulin P, Lundell K, Nunez L, Strandhagen E, et al. Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease. J Lipid Res. 2010;51:103-11 pubmed publisher
    Promoter polymorphisms in microsomal triglyceride transfer protein (MTTP) have been associated with decreased plasma lipids but an increased risk for ischemic heart disease (IHD), indicating that MTTP influences the susceptibility for IHD ..
  25. Jun D, Han J, Jang E, Kim S, Kim S, Jo Y, et al. Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans. Eur J Gastroenterol Hepatol. 2009;21:667-72 pubmed publisher
    ..We investigated a large-scale analysis of the association between microsomal triglyceride transfer protein (MTTP) and phosphatidylethanolamine N-methyltransferase (PEMT) polymorphism in alcoholic and ..
  26. Phillips C, Mullan K, Owens D, Tomkin G. Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes. QJM. 2004;97:211-8 pubmed
    b>Microsomal triglyceride transfer protein (MTP) regulates the assembly of chylomicrons in the intestine and very-low-density lipoprotein (VLDL) in the liver...
  27. Namikawa C, Shu Ping Z, Vyselaar J, Nozaki Y, Nemoto Y, Ono M, et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J Hepatol. 2004;40:781-6 pubmed
    ..Two functional polymorphisms were studied: the -493 G/T polymorphism in the promoter of microsomal triglyceride transfer protein (MTP) and the 1183 T/C polymorphism in the mitochondrial targeting sequence of manganese ..
  28. Ledmyr H, McMahon A, Ehrenborg E, Nielsen L, Neville M, Lithell H, et al. The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Circulation. 2004;109:2279-84 pubmed
    The microsomal triglyceride transfer protein (MTP) transfers lipids into apolipoprotein B-containing lipoproteins for secretion from liver, intestine, and heart...
  29. Wetterau J, Lin M, Jamil H. Microsomal triglyceride transfer protein. Biochim Biophys Acta. 1997;1345:136-50 pubmed
  30. Neville M, Clarke R, Evans J, Rubinsztein D, Karpe F. Absence of relationship between MTTP haplotypes and longevity. J Gerontol A Biol Sci Med Sci. 2007;62:202-5 pubmed
    Polymorphisms for the microsomal triglyceride transfer protein (MTTP) gene have been associated with longevity and with lower risk for cardiovascular mortality...
  31. Okabe S, Tauchi T, Tanaka Y, Sakuta J, Ohyashiki K. Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells. Oncotarget. 2015;6:20231-40 pubmed
    The potency of Abelson (ABL) tyrosine kinase inhibitors (TKIs) against chronic myeloid leukemia (CML) has been demonstrated. However, ABL TKI resistance can develop...
  32. Shantzer L, Berger K, Pu J. Primary myelofibrosis and its targeted therapy. Ann Hematol. 2017;96:531-535 pubmed publisher
    Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia...
  33. Morita S, Villalta S, Feldman H, Register A, Rosenthal W, Hoffmann Petersen I, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017;25:883-897.e8 pubmed publisher
    ..Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α's enzymatic activities, thereby potentiating ER stress-..
  34. Gorgani Firuzjaee S, Meshkani R. SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells. Free Radic Biol Med. 2015;89:679-89 pubmed publisher
    ..secretion of apoB containing lipoprotein in HepG2 cells, as demonstrated by a reduction in both secreted apoB and MTP expression, and decreased triglyceride levels and the expression of lipogenic genes such as SREBP1c, FAS and ACC...
  35. Grosch J, Sieben M, Lattermann C, Kauffmann K, Büchs J, Spieß A. Enzyme activity deviates due to spatial and temporal temperature profiles in commercial microtiter plate readers. Biotechnol J. 2016;11:519-29 pubmed publisher
    Microtiter plates (MTP) and automatized techniques are increasingly applied in the field of biotechnology...
  36. Yeung C, Egan D, Radich J. New Methodologies in the Molecular Monitoring of CML. Curr Hematol Malig Rep. 2016;11:94-101 pubmed publisher
    In chronic myeloid leukemia (CML), the BCR-ABL fusion gene is both the therapeutic target of tyrosine kinase inhibitors and the indisputable direct marker of disease burden...
  37. Kolovou G, Kolovou V, Papadopoulou A, Watts G. MTP Gene Variants and Response to Lomitapide in Patients with Homozygous Familial Hypercholesterolemia. J Atheroscler Thromb. 2016;23:878-83 pubmed publisher
    ..Microsomal triglyceride transport protein (MTP) inhibitors, such as lomitapide, offer a new therapeutic approach for treating these patients...
  38. Saha B, Kennedy G. Ninety six well microtiter plate as microbioreactors for production of itaconic acid by six Aspergillus terreus strains. J Microbiol Methods. 2018;144:53-59 pubmed publisher
    ..mixed sugars, and both dilute acid and liquid hot water pretreated wheat straw hydrolyzates in microtiter plate (MTP) microbioreactors at 100μL scale...
  39. Srivatsa U, Danielsen B, Amsterdam E, Yang Y, Fan D, Pezeshkian N, et al. California study of Ablation (CAABL):early utilization after index hospitalization for non-valvular atrial fibrillation. J Atr Fibrillation. 2017;10:1599 pubmed publisher
    Catheter ablation (ABL) for non-valvular AF (NVAF) is recommended for symptomatic patients refractory to medical therapy and its success is related to the duration of the arrhythmia prior to intervention...
  40. Chakraborty D, Šumová B, Mallano T, Chen C, Distler A, Bergmann C, et al. Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Nat Commun. 2017;8:1130 pubmed publisher
    ..studies in vitro and in vivo demonstrate that STAT3 activation is mediated by the combined action of JAK, SRC, c-ABL, and JNK kinases. STAT3-deficient fibroblasts are less sensitive to the pro-fibrotic effects of TGF?...
  41. le Coutre P, Giles F, Hochhaus A, Apperley J, Ossenkoppele G, Blakesley R, et al. Nilotinib in patients with Ph+ chronic myeloid leukemia in accelerated phase following imatinib resistance or intolerance: 24-month follow-up results. Leukemia. 2012;26:1189-94 pubmed publisher
    Nilotinib (Tasigna) is a potent and selective BCR-ABL inhibitor approved for use in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CML-CP) and in patients with CML-CP and accelerated phase (CML-AP) who are ..
  42. Soares M, Sahrari K, Amorim C, Saussoy P, Donnez J, Dolmans M. Evaluation of a human ovarian follicle isolation technique to obtain disease-free follicle suspensions before safely grafting to cancer patients. Fertil Steril. 2015;104:672-80.e2 pubmed publisher
    ..The BCR-ABL fusion transcript was detected when at least 19 cells were present in follicle suspensions; four samples were ..
  43. Leclerc G, DeSalvo J, Du J, Gao N, Leclerc G, Lehrman M, et al. Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress. Leuk Res. 2015;: pubmed publisher
    BCR-ABL positive (+) acute lymphoblastic leukemia (ALL) accounts for ∼30% of cases of ALL...
  44. Graf S, Haigh S, Corson E, Shirihai O. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004;279:42954-63 pubmed
    ..We report that ABCB10 possesses an unusually long 105-amino acid mitochondrial targeting presequence (mTP)...
  45. Gao X, Liu J, Liu X, Li L, Zheng J. Cleavage and phosphorylation: important post-translational modifications of galectin-3. Cancer Metastasis Rev. 2017;36:367-374 pubmed publisher
    ..Serine and tyrosine phosphorylation of galectin-3 by c-Abl, CKI, and GSK-3? could regulate its localization and associated signal transduction...
  46. Newberry E, Xie Y, Kennedy S, Graham M, Crooke R, Jiang H, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology. 2017;65:836-852 pubmed publisher
    ..hepatic very low-density lipoprotein secretion through genetic or pharmacologic inhibition of microsomal triglyceride transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly ..
  47. Markert S, Joeris K. Establishment of a fully automated microtiter plate-based system for suspension cell culture and its application for enhanced process optimization. Biotechnol Bioeng. 2017;114:113-121 pubmed publisher
    We developed an automated microtiter plate (MTP)-based system for suspension cell culture to meet the increased demands for miniaturized high throughput applications in biopharmaceutical process development...
  48. Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Lohr F, et al. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun. 2017;8:2101 pubmed publisher
    The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network, despite similar kinase activity...
  49. Karaa A, Haas R, Goldstein A, Vockley J, Weaver W, Cohen B. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy. Neurology. 2018;90:e1212-e1221 pubmed publisher
    ..A Study Investigating the Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy (MMPOWER) was a phase I/II multicenter, randomized, double-blind, ..
  50. Lim G, Harper Kirksey K, Parekh R, Manini A. Efficacy of a massive transfusion protocol for hemorrhagic trauma resuscitation. Am J Emerg Med. 2018;36:1178-1181 pubmed publisher
    ..trauma resuscitation recommend that early reconstitution of whole blood ratios with massive transfusion protocols (MTP) may be associated with improved survival...
  51. Shin J, Mooney D. Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias. Proc Natl Acad Sci U S A. 2016;113:12126-12131 pubmed
    ..cells, in a biphasic manner by autocrine regulation, whereas it decreases that of chronic myeloid leukemia BCR-ABL+ K-562 cells...
  52. Vinhas R, Correia C, Ribeiro P, Lourenço A, Botelho de Sousa A, Fernandes A, et al. Colorimetric assessment of BCR-ABL1 transcripts in clinical samples via gold nanoprobes. Anal Bioanal Chem. 2016;408:5277-84 pubmed publisher
    ..Here, we used a colorimetric method based on Au-nanoprobes for the direct detection of the e14a2 BCR-ABL fusion transcript in myeloid leukemia patient samples without the need for retro-transcription...
  53. Najah M, Youssef S, Yahia H, Afef S, Awatef J, Saber H, et al. Molecular characterization of Tunisian families with abetalipoproteinemia and identification of a novel mutation in MTTP gene. Diagn Pathol. 2013;8:54 pubmed publisher
    ..ABL results from genetic deficiency in microsomal triglyceride transfer protein (MTP; OMIM 157147)...
  54. Kirzioğlu F, Ozmen O, Dogan B, Bulut M, Fentoglu O, Ozdem M. Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis. J Periodontal Res. 2017;: pubmed publisher
    ..The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature-induced experimental periodontitis with/without ..
  55. Inokuchi K, Sawano M, Yamamoto K, Yamaguchi A, Sugiyama S. Early administration of fibrinogen concentrates improves the short-term outcomes of severe pelvic fracture patients. Acute Med Surg. 2017;4:271-277 pubmed publisher
    ..Thus, we revised our massive transfusion protocol (MTP) in April 2013 to include early off-label administration of fibrinogen concentrate...
  56. Sani M, Sabbaghian M, Mahjoob F, Cefalù A, Averna M, Rezaei N. Identification of a novel mutation of MTP gene in a patient with abetalipoproteinemia. Ann Hepatol. 2011;10:221-6 pubmed
    Abetalipoproteinemia (ABL), or Bassen-Kornzweig syndrome, is a rare autosomal recessive disorder of lipoprotein metabolism, characterized by fat malabsorption, hypocholesterolemia retinitis pigmentosa, progressive neuropathy and ..
  57. Zhou J, Nie D, Li J, Du X, Lu Y, Li Y, et al. PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia. Clin Cancer Res. 2018;24:145-157 pubmed publisher
    ..b>Experimental Design: Human primary CML CD34+ cells and retrovirally BCR-ABL-driven CML mouse models were employed to evaluate the effects of suppression of EZH2 by GSK126- or ..
  58. Pan S, Luo X, Lu Z, Lu S, Luo H, Liu C, et al. Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China. Lipids Health Dis. 2012;11:177 pubmed publisher
    The -493G/T polymorphism in the microsomal triglyceride transfer protein (MTP) gene is associated with lower serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and longevity in several populations, but the ..
  59. Gambino R, Bo S, Musso G, Uberti B, Alemanno N, Ghione F, et al. Microsomal triglyceride transfer protein 493-T variant is associated with resistin levels and C-reactive protein. Clin Biochem. 2007;40:1219-24 pubmed
    The microsomal triglyceride transfer protein (MTP) is a heterodimeric lipid transfer protein that consists of a large unique 97-kDA subunit and protein disulfide isomerase...
  60. Schroll R, Swift D, Tatum D, Couch S, Heaney J, Llado Farrulla M, et al. Accuracy of shock index versus ABC score to predict need for massive transfusion in trauma patients. Injury. 2018;49:15-19 pubmed publisher
    ..ABC) score and Shock Index (SI) have been shown to be reliable predictors for Massive Transfusion Protocol (MTP) activation...
  61. Steinhilber D, Marschalek R. How to effectively treat acute leukemia patients bearing MLL-rearrangements ?. Biochem Pharmacol. 2018;147:183-190 pubmed publisher
    ..of them represent altered transcription factors that affect transcription or epigenetics, while others - like BCR-ABL - are enhancing signaling...
  62. Menon H. Non-adherence to CML therapy and its clinical implications in India. Natl Med J India. 2017;30:142-147 pubmed
    ..A systematic literature review of CML studies reporting adherence to BCR-ABL inhibitors from the USA, Asia and Europe (19 articles: 9 retrospective, 4 prospective, rest cross-sectional) showed ..
  63. Li C, Park S, Zhang X, Eisenberg L, Zhao H, Darzynkiewicz Z, et al. Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism. J Biol Chem. 2017;292:16746-16759 pubmed publisher
    ..DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl)...
  64. Chen C, Wicha S, de Knegt G, Ortega F, Alameda L, Sousa V, et al. Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models. CPT Pharmacometrics Syst Pharmacol. 2017;6:787-797 pubmed publisher
    ..Mycobacterium tuberculosis using population pharmacokinetics (PKs), the Multistate Tuberculosis Pharmacometric (MTP) model, and the General Pharmacodynamic Interaction (GPDI) model...
  65. Li Y, Deutzmann A, Choi P, Fan A, Felsher D. BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia. Oncotarget. 2016;7:26926-34 pubmed publisher
    ..Here we report that in MYC-, RAS-, and BCR-ABL-induced acute lymphoblastic leukemia (ALL), apoptosis upon oncogene inactivation is mediated by the same pro-..
  66. Linder K, Iragavarapu C, Liu D. SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndrome. Biomark Res. 2017;5:33 pubmed publisher
    ..Specific disorders include chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), BCR-ABL negative atypical chronic myeloid leukemia (aCML) and unclassifiable MDS/MPN (MPN/MDS-U)...
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    b>Microsomal triglyceride transfer protein (MTP) catalyzes the assembly of triglyceride (TG)-rich apolipoprotein B-containing liver (e.g., VLDL) and intestinal (e.g., chylomicron) lipoproteins...
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    ..Abetalipoproteinemia (ABL) is a recessive disorder due to mutations of microsomal triglyceride transfer protein (MTP) gene...
  69. Liu Z, Li Y, Lv C, Wang L, Song H. Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway. Biochem Biophys Res Commun. 2016;478:893-9 pubmed publisher
    Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP)...
  70. Linnik K, Herscovitz H. Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. J Biol Chem. 1998;273:21368-73 pubmed
    ..apoB lipidation as they secrete both unlipidated and lipidated apoB forms despite their lack of microsomal triglyceride transfer protein (MTP), which mediates lipidation of apoB in HepG2 cells...
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    ..levels of hematopoietic factors, including GATA?1, NF-E2 and GATA?2, were elevated, while expression levels of BCR?ABL were downregulated in K562 cells after 24 h of treatment with ITR?284 as determined by quantitative reverse ..
  72. Xu P, Guo D, Shao X, Peng M, Chen B. Characteristics and mutation analysis of Ph-positive leukemia patients with T315I mutation receiving tyrosine kinase inhibitors. Onco Targets Ther. 2017;10:4731-4738 pubmed publisher
    ..is frequently observed, mainly due to mutations within the breakpoint cluster region-Abelson leukemia virus (BCR-ABL) kinase domain. The T315I substitution confers complete resistance to TKIs...
  73. Pagnano K, Miranda E, Delamain M, Duarte G, de Paula E, Lorand Metze I, et al. Influence of BCR-ABL Transcript Type on Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib. Clin Lymphoma Myeloma Leuk. 2017;17:728-733 pubmed publisher
    ..Exclusively patients with BCR-ABL transcripts e13a2 and/or e14a2 were included in this analysis...
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    ..initially, 2 diagnostic tests were performed: cytogenetic analysis and qualitative molecular testing of the BCR-ABL transcript. The male-to-female sex ratio was 3:1. The median age at diagnosis was 49 years, and the mean age was 44...
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    ..Circumstantial evidence suggests that the cytokine microenvironment may play a role in BCR-ABL mediated leukemogenesis and in imatinib resistance...
  76. Tong H, Qi D, Guan X, Jiang G, Liao Z, Zhang X, et al. c-Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis. J Cell Biochem. 2018;119:2806-2817 pubmed publisher
    ..In this study, we found that physiological shear stress induces c-Abl kinase activation in neutrophils, and c-Abl kinase inhibitor impaired neutrophil crawling behavior on ICAM-1...