Gene Symbol: MICB
Description: MHC class I polypeptide-related sequence B
Alias: PERB11.2, MHC class I polypeptide-related sequence B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog
Species: human
Products:     MICB

Top Publications

  1. Bahram S, Bresnahan M, Geraghty D, Spies T. A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1994;91:6259-63 pubmed
  2. Wu J, Zhang X, Shi K, Chen Y, Ren Y, Song Y, et al. Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. Carcinogenesis. 2014;35:155-63 pubmed publisher
    ..The major histocompatibility complex class I-related molecules A and B (MICA and MICB) are NKG2D ligands that play important roles in tumor immune surveillance...
  3. Khor C, Chau T, Pang J, Davila S, Long H, Ong R, et al. Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nat Genet. 2011;43:1139-41 pubmed publisher
    ..SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC ..
  4. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci U S A. 1996;93:12445-50 pubmed
    ..Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes...
  5. Lopez Arbesu R, Ballina Garcia F, Alperi López M, Lopez Soto A, Rodriguez Rodero S, Martinez Borra J, et al. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. Rheumatology (Oxford). 2007;46:426-30 pubmed
    ..In this study, we investigate whether inhibitor of kappaB-like (IkappaBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA...
  6. Jinushi M, Takehara T, Tatsumi T, Kanto T, Groh V, Spies T, et al. Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid. Int J Cancer. 2003;104:354-61 pubmed
    ..Distant MHC class I homologs MICA and MICB are recently identified human ligands for NK cell activating receptor NKG2D...
  7. Kato N, Tanaka J, Sugita J, Toubai T, Miura Y, Ibata M, et al. Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. Leukemia. 2007;21:2103-8 pubmed
    ..against tumors by recognizing its ligands major histocompatibility complex class I-related chain A and B (MICA and MICB) on tumor cells...
  8. Leelayuwat C, Townend D, Degli Esposti M, Abraham L, Dawkins R. A new polymorphic and multicopy MHC gene family related to nonmammalian class I. Immunogenetics. 1994;40:339-51 pubmed
    ..The results suggest that we have identified a novel polymorphic gene family with multiple copies within the MHC. ..
  9. Yamamoto K, Fujiyama Y, Andoh A, Bamba T, Okabe H. Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2). Biochim Biophys Acta. 2001;1526:10-2 pubmed
    The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family...

More Information


  1. Venkataraman G, Suciu D, Groh V, Boss J, Spies T. Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D. J Immunol. 2007;178:961-9 pubmed
    ..Altogether, these results reveal distinct modes of activation of the genes for the MIC ligands of NKG2D and provide a molecular framework for analyses of gene regulation under different cellular insult conditions. ..
  2. Steinle A, Li P, Morris D, Groh V, Lanier L, Strong R, et al. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics. 2001;53:279-87 pubmed
    ..MICA glycosylation was not essential but enhanced complex formation. Soluble NKG2D also bound to cell surface MICB, which has structural and functional properties similar to those of MICA...
  3. Cosman D, Mullberg J, Sutherland C, Chin W, Armitage R, Fanslow W, et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 2001;14:123-33 pubmed
    ..glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class I family but are only distantly related ..
  4. Groh V, Steinle A, Bauer S, Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science. 1998;279:1737-40 pubmed
    ..MICA and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vdelta1 gammadelta TCRs...
  5. Tamaki S, Kawakami M, Ishitani A, Kawashima W, Kasuda S, Yamanaka Y, et al. Soluble MICB serum levels correlate with disease stage and survival rate in patients with oral squamous cell carcinoma. Anticancer Res. 2010;30:4097-101 pubmed
    ..Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases...
  6. Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature. 2002;419:734-8 pubmed
    ..Ligands of NKG2D include the major histocompatibility complex class I homologues MICA and MICB, which function as signals of cellular stress...
  7. Cerwenka A, Bakker A, McClanahan T, Wagner J, Wu J, Phillips J, et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 2000;12:721-7 pubmed
    ..These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity. ..
  8. Hughes E, Collins R, Kondeatis E, Wallace G, Graham E, Vaughan R, et al. Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients. Tissue Antigens. 2005;66:195-9 pubmed
    ..BD and 90 Caucasian controls were analysed by polymerase chain reaction using allele-specific primers for MICA and MICB alleles. An increased allele frequency of MICA*009 was found in the BD patient group (25...
  9. Dunn C, Chalupny N, Sutherland C, Dosch S, Sivakumar P, Johnson D, et al. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J Exp Med. 2003;197:1427-39 pubmed
    ..UL16 is retained in the endoplasmic reticulum and cis-Golgi apparatus of cells and causes MICB to be similarly retained and stabilized within cells...
  10. Nachmani D, Stern Ginossar N, Sarid R, Mandelboim O. Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe. 2009;5:376-85 pubmed publisher
    ..a human cytomegalovirus (HCMV) microRNA represses expression of the stress-induced Natural Killer (NK) cell ligand, MICB, to escape recognition and consequent elimination by NK cells...
  11. Nuckel H, Switala M, Sellmann L, Horn P, Durig J, Duhrsen U, et al. The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:1152-9 pubmed publisher
    ..Our data show that soluble but not membrane-anchored NKG2D ligands or receptors are of prognostic significance in CLL. Moreover, sULBP2 seems to be useful to identify early-stage patients with risk of disease progression. ..
  12. Tosh K, Ravikumar M, Bell J, Meisner S, Hill A, Pitchappan R. Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. Hum Mol Genet. 2006;15:2880-7 pubmed
    ..association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene...
  13. Ahmad T, Marshall S, Mulcahy Hawes K, Orchard T, Crawshaw J, Armuzzi A, et al. High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility. Tissue Antigens. 2002;60:164-79 pubmed
    The highly polymorphic nonclassical MHC class I chain-related (MIC) genes MICA and MICB encode stress inducible glycoproteins expressed on a variety of epithelial cells including intestinal cells...
  14. Bahram S, Spies T. Nucleotide sequence of a human MHC class I MICB cDNA. Immunogenetics. 1996;43:230-3 pubmed
  15. Wu J, Chalupny N, Manley T, Riddell S, Cosman D, Spies T. Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein. J Immunol. 2003;170:4196-200 pubmed
    Infection by human CMV induces expression of the cellular MHC class I-related chain A (MICA) and chain B (MICB) surface proteins, which function as ligands for the activating NKG2D receptor...
  16. McSharry B, Burgert H, Owen D, Stanton R, Prod homme V, Sester M, et al. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. J Virol. 2008;82:4585-94 pubmed publisher
    ..synthesis of the NKG2D ligands, major histocompatibility complex class I chain-related proteins A and B (MICA and MICB), their expression on the cell surface is actively suppressed...
  17. Bahram S, Shiina T, Oka A, Tamiya G, Inoko H. Genomic structure of the human MHC class I MICB gene. Immunogenetics. 1996;45:161-2 pubmed
  18. Welte S, Sinzger C, Lutz S, Singh Jasuja H, Sampaio K, Eknigk U, et al. Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. Eur J Immunol. 2003;33:194-203 pubmed
    ..However, solely MICA and ULBP3 reach the cellular surface to engage NKG2D, whereas MICB, ULBP1 and ULBP2 are selectively retained in the endoplasmic reticulum by UL16...
  19. Salih H, Antropius H, Gieseke F, Lutz S, Kanz L, Rammensee H, et al. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood. 2003;102:1389-96 pubmed
    ..The human NKG2DLs MICA and MICB are expressed on tumors of epithelial origin in vivo...
  20. Whitehorn J, Chau T, Nguyet N, Kien D, Quyen N, Trung D, et al. Genetic variants of MICB and PLCE1 and associations with non-severe dengue. PLoS ONE. 2013;8:e59067 pubmed publisher
    A recent genome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360...
  21. Li K, Mandai M, Hamanishi J, Matsumura N, Suzuki A, Yagi H, et al. Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis. Cancer Immunol Immunother. 2009;58:641-52 pubmed publisher
    ..High expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment. ..
  22. Schrambach S, Ardizzone M, Leymarie V, Sibilia J, Bahram S. In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer. PLoS ONE. 2007;2:e518 pubmed
    ..In parallel, a total body tissue scan of both MICA and MICB transcription clearly shows that despite original presumptions, and with the exception of the central nervous ..
  23. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein K, Spies T. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci U S A. 1999;96:6879-84 pubmed
    Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of gamma delta T cells expressing the variable region Vdelta1...
  24. Hue S, Monteiro R, Berrih Aknin S, Caillat Zucman S. Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells. J Immunol. 2003;171:1909-17 pubmed
  25. Rodriguez Rodero S, Rodrigo L, Fdez Morera J, Martinez Borra J, Lopez Vazquez A, Fuentes D, et al. MHC class I chain-related gene B promoter polymorphisms and celiac disease. Hum Immunol. 2006;67:208-14 pubmed
    ..susceptibility to celiac disease (CD) might be influenced by the MHC class I chain-related gene family, MICA and MICB, has been previously reported...
  26. Sester M, Koebernick K, Owen D, Ao M, Bromberg Y, May E, et al. Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins. J Immunol. 2010;184:255-67 pubmed publisher
    ..Thus, distinct conserved amino acids seem preferentially important for a particular functional activity of E3/19K. ..
  27. Salih H, Goehlsdorf D, Steinle A. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. Hum Immunol. 2006;67:188-95 pubmed
    ..Soluble MICA has been proposed to counteract NKG2D-mediated immunosurveillance of tumors. Here, we report that MICB, the second member of the human MIC protein family, is likewise shed by metalloproteases from tumor cells and is ..
  28. Lu M, Xia B, Li J, Ye M, Zhang X, Tan Q. MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population. Clin Immunol. 2006;120:199-204 pubmed
    The MHC class I-related molecules A and B (MICA and MICB) are stress-inducible cell surface antigens that are recognized by immunocytes bearing the receptor NKG2D, including intestinal epithelial Vdelta1 gammadelta T cells, which may play ..
  29. Okita R, Mougiakakos D, Ando T, Mao Y, Sarhan D, Wennerberg E, et al. HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines. J Immunol. 2012;188:2136-45 pubmed publisher
    ..we demonstrate that HER2/HER3 signaling regulates the expression of MHC class I-related chain A and B (MICA and MICB) in breast cancer cell lines...
  30. Le Guen V, Judor J, Boeffard F, Gauttier V, Ferry N, Soulillou J, et al. Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8+ regulatory T cells. J Hepatol. 2017;66:765-777 pubmed publisher
    ..Our present findings open a new avenue for promoting allo-specific tolerance via in vivo induction of CD8+ Treg expansion. ..
  31. Mei J, Guo K, Wei H, Song C. [Expression of NKG2D ligands in multidrug-resistant nasopharyngeal carcinoma cell line CNE2/DDP and their effects on cytotoxicity of natural killer cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:887-9 pubmed
    ..The expression of MHC class I chain-related proteins A and B (MICA and MICB) on CNE2 cells was higher than that on CNE2/DDP cells (P<0.01), and ULBP1 and ULBP3 were not detectable...
  32. Tang K, Ren H, Cao J, Zeng G, Xie J, Chen M, et al. Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB. J Cell Biol. 2008;182:233-9 pubmed publisher
    ..by RNAi in human cells up-regulates major histocompatibility complex class I-related molecules A and B (MICA and MICB)...
  33. Tsukerman P, Enk J, Mandelboim O. Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor. Oncoimmunology. 2013;2:e22245 pubmed
    ..We have recently reported that miR-10b inhibits the expression of MICB, a stress-induced ligand of the activating natural killer (NK)-cell receptor NKG2D...
  34. Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, et al. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis. 2009;199:419-26 pubmed publisher
    ..Interestingly, this single-nucleotide polymorphism (SNP) was in high linkage disequilibrium with HLA-B, MICB, TNF, and several other HLA locus SNPs and haplotypes...
  35. Bateman S, Seed P. Epigenetic regulation of the nitrosative stress response and intracellular macrophage survival by extraintestinal pathogenic Escherichia coli. Mol Microbiol. 2012;83:908-25 pubmed publisher
    ..Collectively, we have shown that the ability of ExPEC to survive in macrophages is contingent upon the proper transition from high to low HyxR expression through epigenetic regulatory control by FimX. ..
  36. Chitadze G, Lettau M, Bhat J, Wesch D, Steinle A, Furst D, et al. Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17. Int J Cancer. 2013;133:1557-66 pubmed publisher
    The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) with the corresponding natural killer group 2, member D (NKG2D) receptor triggers cytotoxic effector activity of natural killer cells and certain T-cell ..
  37. Kanazawa T, Ikeda M, Glatt S, Tsutsumi A, Kikuyama H, Kawamura Y, et al. Genome-wide association study of atypical psychosis. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:679-86 pubmed publisher
    ..01), but not BD. This study provides clues about the types of patient whose diagnosis lies between SZ and BD. Studies with larger samples are required to determine the causal variant. ..
  38. Bhattarai S, Ghannam K, Krause S, Benveniste O, Marg A, de Bruin G, et al. The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies. J Autoimmun. 2016;75:118-129 pubmed publisher
    ..Thus, induction of the immunoproteasome was identified as a pathomechanism underlying inflammation in IIMs. ..
  39. Wang Y, Zhang N, Chen E, Chen C, Bu Y, Yu P. MICA/B genotyping of Tujias from Zhangjiajie, Hunan Province, China. Hum Immunol. 2016;77:340-1 pubmed publisher
    One hundred eighty-seven Tujia individuals from Zhangjiajie, Hunan Province, China were genotyped at the MICA and MICB loci using polymerase chain reaction-sequence specific priming and sequencing-based typing methods...
  40. Lenart M, Gruca A, Mueck A, Rutkowska Zapała M, Surman M, Szaflarska A, et al. Comparison of 6B11 mAb and α-GalCer-loaded CD1d dextramers for detection of iNKT cells by flow cytometry. J Immunol Methods. 2017;446:1-6 pubmed publisher
    ..Moreover, our results indicate that CD3+CD56+ lymphocytes are a heterogeneous population of T cells, expressing activation markers of both NK and T lymphocytes, yet with not well characterized properties. ..
  41. Schafer J, Ries M, Guha N, Connole M, Colantonio A, Wiertz E, et al. Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides. PLoS Pathog. 2015;11:e1005145 pubmed publisher
  42. Prasad S, Bhatia T, Kukshal P, Nimgaonkar V, Deshpande S, Thelma B. Attempts to replicate genetic associations with schizophrenia in a cohort from north India. NPJ Schizophr. 2017;3:28 pubmed publisher
    ..b>MICB (rs6916394) a previously noted Caucasian candidate, was associated with schizophrenia at the p?=?0.02 level...
  43. Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, et al. Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study. Arthritis Rheum. 2012;64:4104-13 pubmed publisher
    ..We propose a model in which up-regulation of STAT4 expression and subsequent STAT4-driven production of inflammatory cytokines, such as IL-17, constitute a potential pathway leading to BD. ..
  44. Nalabolu S, Shukla H, Nallur G, Parimoo S, Weissman S. Genes in a 220-kb region spanning the TNF cluster in human MHC. Genomics. 1996;31:215-22 pubmed
    ..We also independently identified the BAT1 gene to be the well-conserved homologue of a previously described rat liver nuclear protein. ..
  45. Frey B, Jiang J, Sui Y, Boyd L, Yu B, Tatsuno G, et al. Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity. J Immunol. 2018;200:1853-1864 pubmed publisher
  46. de Groot N, Heijmans C, de Ru A, Janssen G, Drijfhout J, Otting N, et al. A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics. J Immunol. 2017;199:3679-3690 pubmed publisher
    ..Thus, the macaque A2*05 gene encodes a specialized MHC class I molecule, and is most likely transported to the cell surface only when suitable peptides become available. ..
  47. Berhani O, Nachmani D, Yamin R, Schmiedel D, Bar On Y, Mandelboim O. Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region. J Immunol. 2017;198:3662-3670 pubmed publisher
    ..This receptor binds stress-induced ligands, including human MICA, MICB, and UL16-binding proteins 1-6...
  48. Wu B, Li W, Qian C, Ding W, Zhou Z, Jiang H. Serum soluble MICB (sMICB) correlates with disease progression and survival in melanoma patients. Tumour Biol. 2013;34:565-9 pubmed publisher
    Recently, it was reported that soluble MICB (sMICB) may impair tumor immunogenicity by reducing natural killer group 2D ligand densities on malignant cells. The aim of this study was to elucidate the role of sMICB in melanoma patients...
  49. Mei J, Zhao J, Yang G, Gao F, Liu G. [Expression of MICA/B protein in esophageal cancer and its clinical significance]. Zhonghua Zhong Liu Za Zhi. 2012;34:745-7 pubmed publisher
    ..012). MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma. ..
  50. Brennan K, McSharry B, Keating S, Petrasca A, O Reilly V, Keane J, et al. Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype. Hum Immunol. 2016;77:876-885 pubmed publisher
    ..Ligands (termed NKG2DL) for this receptor include ULBP1-6, MICA and MICB in humans; they are upregulated in stressed, cancerous or infected cells where they engage NKG2D to induce NK cell ..
  51. Bargostavan M, Eslami G, Esfandiari N, Shams Shahemabadi A. MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer. Iran J Immunol. 2016;13:45-53 pubmed publisher
    ..The polymorphism of MMP9 (-1562 C/T) was determined by PCR-RFLP. Concentration of MICB and MICA in the sera of breast cancer patients and healthy women were measured using ELISA method...
  52. Jinushi M, Takehara T, Kanto T, Tatsumi T, Groh V, Spies T, et al. Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection. J Immunol. 2003;170:1249-56 pubmed
    ..These findings suggested that MICA/B induction on DCs may be one of the mechanisms by which IFN-alpha activates NK cells; this impairment might affect IFN-alpha responsiveness in hepatitis C virus infection. ..
  53. Hui J, Palmer L, James A, Musk A, Beilby J. AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population. Clin Exp Allergy. 2006;36:728-34 pubmed
    To examine the association between the Alu dimorphism within the first intron of the MICB gene and asthma and airflow obstruction...
  54. Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, et al. Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. J Immunol. 2015;195:736-48 pubmed publisher
    ..whether genotoxic stress could promote the release of NK group 2D ligands (MHC class I-related chain [MIC]A and MICB), as well as the molecular mechanisms underlying this event in human multiple myeloma (MM) cells...
  55. Huang S, Chiang C, Chen F, Yu C. The alteration of placental-derived soluble MHC class I chain-related protein A and B during pregnancy. Acta Obstet Gynecol Scand. 2011;90:802-7 pubmed publisher
    ..Furthermore, we suggest that the effect of soluble MICA/B on natural killer cells of pregnant women is limited to the maternal placental surface, but not transferred through the placenta into the amniotic cavity. ..
  56. Whitehorn J, Kien D, Quyen N, Wills B, Van Vinh Chau N, Tam D, et al. Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue. BMC Infect Dis. 2017;17:412 pubmed publisher
    A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations...
  57. Andresen L, Hansen K, Jensen H, Pedersen S, Stougaard P, Hansen H, et al. Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells. J Immunol. 2009;183:897-906 pubmed publisher
    ..We propose that propionate, produced either by bacteria or during cellular metabolism, has significant immunoregulatory function and may be cancer prophylactic. ..
  58. Rodriguez Rodero S, Gonzalez S, Rodrigo L, Fernández Morera J, Martinez Borra J, Lopez Vazquez A, et al. Transcriptional regulation of MICA and MICB: a novel polymorphism in MICB promoter alters transcriptional regulation by Sp1. Eur J Immunol. 2007;37:1938-53 pubmed
    ..We also demonstrate that MICB promoter is polymorphic, showing three single nucleotide polymorphisms (C>G at +16, -341, -408) and a deletion ..
  59. Chiang E, Stroynowski I. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol. 2004;173:4394-401 pubmed
    ..Collectively, these studies demonstrate that a MHC class Ib molecule can serve as a restriction element for antitumor CTL and mediate protective immune responses in a syngeneic setting...
  60. Liu X, Li L, Pan F, Tian W. MICB polymorphism in a southern Chinese Han population: the identification of two new MICB alleles, MICB*005:06 and MICB*026. Hum Immunol. 2012;73:818-23 pubmed publisher
    In this study, we investigated the major histocompatibility complex (MHC) class I chain-related gene B (MICB) allelic variation by sequence-based typing (SBT) in 201 healthy, unrelated Han subjects from Hunan province, southern China...
  61. Quiroga I, Lehmann D, Barnardo M, Fuggle S, Cortina Borja M, Warden D, et al. Association study of MICA and MICB in Alzheimer's disease. Tissue Antigens. 2009;74:241-3 pubmed publisher
    ..in a previous study, we examined whether that association could be due to linkage disequilibrium with MICA or MICB alleles...
  62. González Foruria I, Santulli P, Chouzenoux S, Carmona F, Batteux F, Chapron C. Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity. PLoS ONE. 2015;10:e0119961 pubmed publisher
    ..were obtained from all study participants during the surgery in order to detect soluble NKG2D ligands (MICA, MICB and ULBP-2)...
  63. Abediankenari S, Yousefzadeh Y, Majidi M, Ghasemi M, Nasehi M, Ghaffari J, et al. MICB gene expression on peripheral blood mononuclear cells and susceptibility to multiple sclerosis in north of Iran. Iran J Allergy Asthma Immunol. 2011;10:261-5 pubmed publisher
    ..MHC class I chain- related geneA,B(MICA and MICB) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation...
  64. Ribeiro C, Kramm K, Gálvez Jirón F, Pola V, Bustamante M, Contreras H, et al. Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients. Oncol Rep. 2016;35:1309-17 pubmed publisher
    ..In the present study, MICA and MICB expression was analyzed, by flow cytometry, in 23 and 20 pairs of gastric tumor and adjacent non-neoplasic gastric ..
  65. Ge S, Duan L, Luo Y, Suo T, Lu C, Tang J. [Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:312-6 pubmed
  66. Chen Z, Zhang N, Qi J, Chen R, Dijkstra J, Li X, et al. The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System. J Immunol. 2017;199:3668-3678 pubmed publisher
    ..This demonstration of the structure of a bony fish MHC class I molecule provides a foundation for understanding the evolution of primitive class I molecules, how they present peptide Ags, and how they might control T cell responses. ..
  67. Schneider C, Hudson A. The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB. PLoS Pathog. 2011;7:e1002362 pubmed publisher
    ..In addition, U21 downregulates the surface expression of the NK activating ligands MICA and MICB, resulting in a reduction in NK-mediated cytotoxicity...
  68. Chen A, Shen Y, Xia M, Xu L, Pan N, Yin Y, et al. Expression of the nonclassical HLA class I?and MICA/B molecules in human hepatocellular carcinoma. Neoplasma. 2011;58:371-6 pubmed
    HLA-G and HLA-E are nonclassical human MHC class I molecules, which promote tolerance to NK cytotoxicity. MICA and MICB are known to enhance the functions of NK and T cells...
  69. Ghadially H, Brown L, Lloyd C, Lewis L, LEWIS A, Dillon J, et al. MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. Br J Cancer. 2017;116:1208-1217 pubmed publisher
    ..histocompatibility complex (MHC) class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced upon stress, damage or transformation of cells which act as a 'kill me' ..
  70. Holmes M, Li P, Petersdorf E, Strong R. Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D. J Immunol. 2002;169:1395-400 pubmed
  71. Fernandez Morera J, Rodriguez Rodero S, Lahoz C, Tuñon A, Astudillo A, Garcia Suarez O, et al. Soluble MHC class I chain-related protein B serum levels correlate with disease activity in relapsing-remitting multiple sclerosis. Hum Immunol. 2008;69:235-40 pubmed publisher
    ..We investigated the presence of soluble major histocompatibility complex class I chain-related A or B (MICA or MICB) molecules in sera of multiple sclerosis (MS) patients and whether they play a role in the progression of the ..
  72. Shirts B, Kim J, Reich S, Dickerson F, Yolken R, Devlin B, et al. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophr Res. 2007;94:342-53 pubmed
    ..We report associations of SNPs at MICB (MHC class I polypeptide-related sequence B, chromosome 6p21) with cytomegalovirus and herpes simplex virus 1 ..
  73. Taqi M, Waseem D, Ismatullah H, Haider S, Faisal M. In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes. Funct Integr Genomics. 2016;16:335-45 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in PLCE1 and MICB genes increase risk for the development of dengue shock syndrome (DSS)...
  74. Ozlu F, Akcali M, Yildiz S, Yapıcıoğlu Yıldızdaş H, Gözet Y, Atay A. New biomarkers for antenatal infection: MICA and MICB gene expression in preterm babies. J Matern Fetal Neonatal Med. 2019;32:579-583 pubmed publisher
    The human major histocompatibility complex class I chain-related gene A and B (MICA and MICB) is one of the genes in chromosome 6...
  75. Nattermann J, Nischalke H, Hofmeister V, Kupfer B, Ahlenstiel G, Feldmann G, et al. HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. Antivir Ther. 2005;10:95-107 pubmed
    ..These results propose HIV-mediated up-regulation of HLA-E expression as an additional evasion strategy targeting the antiviral activities of NK cells, which may contribute to the capability of the virus in establishing chronic infection...