MICA

Summary

Gene Symbol: MICA
Description: MHC class I polypeptide-related sequence A
Alias: MIC-A, PERB11.1, MHC class I polypeptide-related sequence A, HLA class I antigen, MHC class I chain-related protein A, MHC class I related chain A, MHC class I related sequence A, stress inducible class I homolog, truncated MHC class I polypeptide-related sequence A
Species: human

Top Publications

  1. ncbi Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis
    D P Singal
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Rheumatol 19:451-2. 2001
  2. pmc MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy
    T R Orchard
    Gastroenterology Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Clin Exp Immunol 126:437-40. 2001
  3. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
  4. ncbi Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
    N Jan Chalupny
    Amgen, 1201 Amgen Court West, Seattle, WA 98119 3105, USA
    Biochem Biophys Res Commun 346:175-81. 2006
  5. doi Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis
    Kui Li
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Cancer Immunol Immunother 58:641-52. 2009
  6. ncbi Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Cancer Res 62:6178-86. 2002
  7. ncbi Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
    Nat Immunol 2:255-60. 2001
  8. ncbi Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells
    Sophie Hue
    Laboratory of Immunology, Hopital Necker, Paris, France
    J Immunol 171:1909-17. 2003
  9. pmc Antagonist HIV-1 Gag peptides induce structural changes in HLA B8
    S W Reid
    Laboratory of Molecular Biophysics, Oxford, United Kingdom
    J Exp Med 184:2279-86. 1996
  10. ncbi Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls
    Liene Nikitina-Zake
    Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
    Ann N Y Acad Sci 1037:161-9. 2004

Research Grants

  1. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
  2. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004

Detail Information

Publications114 found, 100 shown here

  1. ncbi Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis
    D P Singal
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Rheumatol 19:451-2. 2001
    We examined the role of MICA gene alleles in susceptibility to rheumatoid arthritis (RA)...
  2. pmc MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy
    T R Orchard
    Gastroenterology Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Clin Exp Immunol 126:437-40. 2001
    MHC class I chain gene A (MICA) is a non-classical Class I gene which is expressed on the surface of epithelia without beta 2-microglobulin...
  3. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  4. ncbi Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
    N Jan Chalupny
    Amgen, 1201 Amgen Court West, Seattle, WA 98119 3105, USA
    Biochem Biophys Res Commun 346:175-81. 2006
    ..Here, we show that the viral gene product UL142 is able to down-regulate another NKG2D ligand, MICA, leading to protection from NK cytotoxicity...
  5. doi Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis
    Kui Li
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Cancer Immunol Immunother 58:641-52. 2009
    To investigate the clinical significance of the expression of the NKG2D ligands MICA/B and ULBP2 in ovarian cancer.
  6. ncbi Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Cancer Res 62:6178-86. 2002
    ..In this study, we analyzed the expression and the functional relevance of MHC class I-related chain A (MICA) and UL16 binding protein (ULBP), the major cellular ligands for human NKG2D, in human tumor cell lines of ..
  7. ncbi Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
    Nat Immunol 2:255-60. 2001
    ..Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 production and T cell proliferation. Thus NKG2D functioned as a costimulatory receptor that can substitute for CD28...
  8. ncbi Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells
    Sophie Hue
    Laboratory of Immunology, Hopital Necker, Paris, France
    J Immunol 171:1909-17. 2003
    The nonclassical MHC class I molecule MHC class I-related chain A (MICA) interacts with the NKG2D receptor expressed at the surface of most peripheral CD8 T cells, gammadelta T cells, and NK cells...
  9. pmc Antagonist HIV-1 Gag peptides induce structural changes in HLA B8
    S W Reid
    Laboratory of Molecular Biophysics, Oxford, United Kingdom
    J Exp Med 184:2279-86. 1996
    ..While the first two mechanisms frequently lead to antagonism, the third has more profound effects on TCR recognition...
  10. ncbi Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls
    Liene Nikitina-Zake
    Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
    Ann N Y Acad Sci 1037:161-9. 2004
    ..4. They modulate NK cell response by interacting with HLA class I. In addition, polymorphic MICA in HLA class I interacts with non-polymorphic NKG2D receptor on NK cells...
  11. ncbi Molecular regulation of MHC class I chain-related protein A expression after HDAC-inhibitor treatment of Jurkat T cells
    Lars Andresen
    Department of Immunology, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 179:8235-42. 2007
    In this study, we characterize the molecular signal pathways that lead to MHC class I chain-related protein A (MICA) expression after histone deacetylase (HDAC)-inhibitor (HDAC-i) treatment of Jurkat T cells...
  12. ncbi Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells
    N Kato
    Department of Hematology and Oncology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    Leukemia 21:2103-8. 2007
    ..against tumors by recognizing its ligands major histocompatibility complex class I-related chain A and B (MICA and MICB) on tumor cells...
  13. ncbi Diversity of MICA (PERB11.1) and HLA haplotypes in Northeastern Thais
    A V Romphruk
    Blood Transfusion Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Tissue Antigens 58:83-9. 2001
    b>MICA or PERB11.1 is a polymorphic major histocompatibility complex (MHC) class I-related gene located 46 kb centromeric of the HLA-B gene in the HLA class I region...
  14. ncbi Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden
    Manu Gupta
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Hum Immunol 64:553-61. 2003
    ..In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals < or = 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients...
  15. ncbi Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adults
    Carina Torn
    Institution of Medicine, Lund University, Lund, Sweden
    Hum Immunol 64:902-9. 2003
    Major histocompatibility complex class I chain-related gene A (MICA) encodes polymorphic, stress-inducible antigens recognized by gammadelta T cells within the intestinal epithelium...
  16. ncbi MICA and recovery from hepatitis C virus and hepatitis B virus infections
    P S Karacki
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Genes Immun 5:261-6. 2004
    The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells...
  17. ncbi MICA gene polymorphism in the pathogenesis of type 1 diabetes
    G Gambelunghe
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann N Y Acad Sci 1110:92-8. 2007
    ..Major histocompatibility complex (MHC) class I chain-related A (MICA) is located in a candidate susceptibility region and activates natural killer (NK) cells, T cells and gammadelta ..
  18. doi Association between soluble MICA levels and disease stage IV oral squamous cell carcinoma in Japanese patients
    Shigehiro Tamaki
    Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan
    Hum Immunol 69:88-93. 2008
    The soluble form of major histocompatibility complex class I-related chain A (MICA) is released from the surface of tumor cells of epithelial origin...
  19. doi Relationship between soluble MICA and the MICA A5.1 homozygous genotype in patients with oral squamous cell carcinoma
    Shigehiro Tamaki
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Clin Immunol 130:331-7. 2009
    ..can promote the lysis of target cells by binding to the major histocompatibility complex class I-related chain A (MICA) proteins. Polymorphisms in MICA may influence its binding to the NKG2D...
  20. pmc Role of major histocompatibility complex class I-related molecules A*A5.1 allele in ulcerative colitis in Chinese patients
    Min Lu
    Internal Medicine Department, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    Immunology 128:e230-6. 2009
    The major histocompatibility complex (MHC) class I-related molecules A (MICA) is a stress-inducible cell surface antigen that is recognized by intestinal epithelial Vdelta1 gammadelta T cells, natural killer (NK) cells and CD8(+) T cells ..
  21. doi High levels of soluble Major Histocompatibility Complex class I related chain A (MICA) are associated with biliary cast syndrome after liver transplantation
    Yizhou Zou
    Department of Immunology, Xiang Ya School of Medicine, Central South University, Hunan, China
    Transpl Immunol 21:210-4. 2009
    ..Previous research has demonstrated that the soluble form of MICA (sMICA) is significantly higher in patients with chronic liver disease and hepatocellular carcinoma (HCC) than in ..
  22. doi MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease
    Wahid Boukouaci
    Laboratoire d Immunologie et d Histocompatibilité, Centre d Innovations Biomédicales Hématologie Oncologie Greffe CIB HOG, Institut Universitaire d Hématologie IUH, and INSERM, UMRS, 940, Hopital Saint Louis, Paris, France
    Blood 114:5216-24. 2009
    The MHC class I-related chain A (MICA) molecules exist as membrane-bound and soluble isoforms and are encoded by a polymorphic gene...
  23. doi The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia
    H Nuckel
    Department of Haematology, University Hospital Essen, Essen, Germany
    Leukemia 24:1152-9. 2010
    ..The flow cytometric analysis of MICA on CLL cells and natural killer group 2 member D (NKG2D) receptors on NK cells was performed after thawing of ..
  24. doi Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients
    Jie Zhao
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 26:593-8. 2011
    The aim of the present study was to evaluate the contribution of the dimorphism (MICA-129 val and met) to the genetic susceptibility and functions of ulcerative colitis (UC) in patients in central China.
  25. doi Association of major histocompatibility complex class I chain-related gene A microsatellite polymorphism and hepatocellular carcinoma in South China Han population
    X Jiang
    Department of Immunology, Xiang Ya School of Medicine, Central South University, Changsha, China
    Tissue Antigens 78:143-7. 2011
    The major histocompatibility complex (MHC) class I-related gene A (MICA) is a stress-induced antigen and plays a key role in anti-infectious and anti-tumoral immune responses...
  26. pmc Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 93:12445-50. 1996
    ..They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes...
  27. ncbi MICA 5.1 allele is a susceptibility marker for psoriasis in the Korean population
    H B Choi
    Catholic Hemopoietic Stem Cell Bank, Seoul, Korea
    Tissue Antigens 56:548-50. 2000
    In order to investigate the possibility that the MICA gene is involved in the pathogenesis of psoriasis, microsatellite polymorphism in the transmembrane region of MICA was studied in 138 Korean patients with psoriasis and compared with ..
  28. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
    ..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D.
  29. pmc Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 96:6879-84. 1999
    Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of gamma delta T cells expressing the variable region Vdelta1...
  30. ncbi Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid
    Masahisa Jinushi
    Osaka University Graduate School of Medicine, Department of Molecular Therapeutics, Suita, Osaka, Japan
    Int J Cancer 104:354-61. 2003
    ..Distant MHC class I homologs MICA and MICB are recently identified human ligands for NK cell activating receptor NKG2D...
  31. doi Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:141-50. 2009
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex...
  32. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Ten microsatellite markers in the HLA class III and I regions (D6S273, TNFa, C12A, STR MICA, MIB, C125, C143, C245, C3211, and MOGc) and selected alleles of the HLA-A and HLA-B genes were studied...
  33. ncbi Effect of human cytomegalovirus on expression of MHC class I-related chains A
    Yizhou Zou
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 174:3098-104. 2005
    The MHC-encoded MHC class I-related chains A (MICA) glycoproteins are known to enhance the functions of NK and T cells by ligating the stimulating receptor NKG2D and appear to play an important role in host defense...
  34. ncbi Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease
    Nazli Azimi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Immunogenetics 58:252-8. 2006
    ..Among its ligands are the human major histocompatibility complex class I-related MICA and MICB, which have a restricted tissue distribution but are frequently associated with malignancies and some ..
  35. ncbi Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
    Cristina Cerboni
    Department of Experimental Medicine and Pathology, Istituto Pasteur Fondazione Cenci Bolognetti, University La Sapienza, 00161 Rome, Italy
    J Gen Virol 88:242-50. 2007
    ..interfere with the expression of NK cell-activating ligands, specifically the human leukocyte antigen (HLA)-I-like MICA and ULBP molecules that bind NKG2D, an activating receptor expressed by all NK cells...
  36. ncbi An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients
    Shigehiro Tamaki
    Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan
    J Oral Pathol Med 36:351-6. 2007
    Recently, a new polymorphic gene family called the major histocompatibility complex class I chain-related gene A (MICA) was discovered about 40 kb centromeric to HLA-B gene...
  37. doi Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians
    A Shastry
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Immunogenet 35:439-46. 2008
    ..Our results suggest that a combination KIR2DL2- HLA-C1 plays a critical role in susceptibility or protection in Latvians against type 1 diabetes...
  38. doi MICA polymorphism: biology and importance in immunity and disease
    Mun Kit Choy
    Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Box 110, Level 6, Addenbrooke s Centre for Clinical Investigation ACCI, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Trends Mol Med 16:97-106. 2010
    The human major histocompatibility complex class I chain-related gene A (MICA) is one of the genes in the HLA class I region of chromosome 6...
  39. ncbi MICA haplotypic diversity
    N Fodil
    Centre de Recherche d Immunologie et d Hématologie, Strasbourg, France
    Immunogenetics 49:557-60. 1999
  40. ncbi MICA polymorphism is associated with type 1 diabetes in the Korean population
    Y Park
    Department of Internal Medicine, Hanyang and Seoul National University, School of Medicine, Korea
    Diabetes Care 24:33-8. 2001
    Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians...
  41. ncbi Primary association of a MICA allele with protection against rheumatoid arthritis
    A Martinez
    Hospital La Paz, Madrid, Spain
    Arthritis Rheum 44:1261-5. 2001
    To determine whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) independently of the HLA-DRB1 shared epitope (SE).
  42. ncbi The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia
    Julio C Delgado
    Center for Blood Research, Boston, MA 02115, USA
    Immunogenetics 55:497-501. 2003
    ..The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been ..
  43. ncbi Soluble MICA in malignant diseases
    Stefan Holdenrieder
    Institute of Clinical Chemistry, University Hospital of Munich Grosshadern, Ludwig Maximilians University, Munich, Germany
    Int J Cancer 118:684-7. 2006
    The immunoreceptor NKG2D activates natural killer cells and costimulates CD8 T cells. The MHC class I-related MICA molecules are ligands of NKG2D and are expressed on malignant, but not on normal, cells...
  44. pmc MHC class I chain-related gene A-A5.1 allele is associated with ulcerative colitis in Chinese population
    Yijuan Ding
    Department of Gastroenterology, Renmin Hospital, Wuhan, Peoples Republic of China
    Clin Exp Immunol 142:193-8. 2005
    The human MHC class I chain-related gene A (MICA) plays a role in regulating protective responses by intestinal epithelial Vdelta1 gamma delta T cells and the polymorphism of MICA were reported to be related to several autoimmune diseases...
  45. pmc A second lineage of mammalian major histocompatibility complex class I genes
    S Bahram
    Division of Tumor Virology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:6259-63. 1994
    ..The MICA gene in this family is located near HLA-B and is by far the most divergent mammalian MHC class I gene known...
  46. ncbi MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes
    N W Zwirner
    University of Texas Southwestern Medical Center, Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas, TX 75235 8886, USA
    Immunogenetics 47:139-48. 1998
    b>MICA is a new polymorphic gene in the HLA region expressed in epithelial cell lines and gastrointestinal epithelium...
  47. ncbi Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 279:1737-40. 1998
    ..The expression of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization...
  48. ncbi The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis
    S Gonzalez
    Hospital Central de Asturias, Oviedo, Spain
    Arthritis Rheum 42:1010-6. 1999
    ..To investigate the relative contribution of HLA antigens in the susceptibility to psoriasis and to localize additional genetic factors involved in psoriatic arthritis (PsA)...
  49. ncbi Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes
    N W Zwirner
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8886, USA
    Hum Immunol 60:323-30. 1999
    b>MICA is a new, highly divergent and polymorphic HLA-related gene that has a similar intron-exon organization as the HLA class I genes...
  50. ncbi Population study of allelic diversity in the human MHC class I-related MIC-A gene
    E W Petersdorf
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 1024, USA
    Immunogenetics 49:605-12. 1999
    ..These results confirm and extend previous knowledge on the polymorphism of MIC-A. The strong positive linkage of certain MIC-A and HLA-B alleles may have implications for studies related to MHC-associated diseases and transplantation...
  51. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors...
  52. ncbi An activating immunoreceptor complex formed by NKG2D and DAP10
    J Wu
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 285:730-2. 1999
    ..with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 ..
  53. ncbi A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative colitis
    K Sugimura
    Department of Internal Medicine III, Niigata University School of Medicine, Niigata, Japan
    Tissue Antigens 57:9-14. 2001
    Major histocompatibility complex (MHC) class I chain-related gene A (MICA) has been found near the HLA-B gene...
  54. ncbi ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    D Cosman
    Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, WA 98101
    Immunity 14:123-33. 2001
    ..Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system...
  55. ncbi Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA
    P Li
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 USA
    Nat Immunol 2:443-51. 2001
    The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for NKG2D, a C-type lectin-like activating immunoreceptor...
  56. ncbi Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population
    S Gonzalez
    Functional Biology Department, University of Oviedo, Asturias, Spain
    Hum Immunol 62:632-8. 2001
    ..other closely related class I loci, such as the major histocompatibility complex class I chain-related gene A (MICA) and tumor necrosis factor (TNF), might play a role in disease development...
  57. ncbi Frequency and distribution in three ethnic populations of single nucleotide polymorphisms in the MICA gene
    E Powell
    Comparative Genomics Laboratory, College of Agriculture, Environmental and Natural Sciences, Tuskegee University, AL 36088, USA
    Mutat Res 432:47-51. 2001
    The Homo sapiens major histocompatibility complex (MHC) class 1 chain related gene A (MICA) was scanned for novel single nucleotide polymorphisms (SNPs) using a panel of DNA samples from African-, Japanese- and Mexican-Americans...
  58. ncbi MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and, Harvard Medical School, Boston, MA 02115, USA
    Immunity 15:83-93. 2001
    ..We show here that the stress-inducible molecule, MICA, is induced on the surface of dendritic and epithelial cells by infection with M. tuberculosis in vitro and in vivo...
  59. ncbi Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
    A Steinle
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Immunogenetics 53:279-87. 2001
    ..Among its ligands is the distant major histocompatibility complex class I homolog MICA, which has no function in antigen presentation but is induced by cellular stress...
  60. ncbi Association of MICA alleles and HLA-B51 in Italian patients with Behçet's disease
    C Salvarani
    Unita di Reumatologia, Ospedale di Reggio Emilia, Italy
    J Rheumatol 28:1867-70. 2001
    To evaluate the distribution of the MHC class I chain related gene A transmembrane (MICA-TM) alleles in Italian patients with Behçet's disease (BD), and to investigate the relative contribution of MICA alleles and HLA-B51 in the ..
  61. pmc MHC class I chain related gene A (MICA) modulates the development of coeliac disease in patients with the high risk heterodimer DQA1*0501/DQB1*0201
    A Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, Oviedo, Spain
    Gut 50:336-40. 2002
    ..The aim of this study was to investigate whether other candidate genes modify the risk of developing different clinical forms of CD...
  62. ncbi MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
    Immunogenetics 53:989-91. 2002
    ..We also studied the distribution of MICA transmembrane alleles in the two clinical forms of the disease...
  63. ncbi MICA triggering signal for NK cell tumor lysis is counteracted by HLA-G1-mediated inhibitory signal
    Catherine Menier
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 100:63-70. 2002
    b>MICA, a highly glycosylated membrane-anchored cell-surface MHC Class I-related chain, has recently been reported to activate NK cell cytolytic responses in epithelial tumors...
  64. ncbi The increase in the frequency of MICA gene A6 allele in oral squamous cell carcinoma
    Liu Chung-Ji
    Department of Dentistry, Taipei Medical University, Taipei, Taiwan
    J Oral Pathol Med 31:323-8. 2002
    Oral squamous cell carcinoma (OSCC) was reported to be associated with immune function. The MICA (MHC class I chain-related gene A) is expressed by keratinocytes and other epithelial cells, and its encoded protein interacts with gamma/..
  65. ncbi Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding
    Helmut R Salih
    Department of Internal Medicine II, University Hospital, Eberhard Karls University, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Immunol 169:4098-102. 2002
    The immunoreceptor NKG2D stimulates tumor immunity through activation of CD8 T cells and NK cells. Its ligand MICA has been shown to be broadly expressed on human tumors of epithelial origin...
  66. ncbi Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    Veronika Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nature 419:734-8. 2002
    ..Ligands of NKG2D include the major histocompatibility complex class I homologues MICA and MICB, which function as signals of cellular stress...
  67. ncbi Distribution of MICA alleles and haplotypes associated with HLA in the Korean population
    Chul Woo Pyo
    Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
    Hum Immunol 64:378-84. 2003
    The MICA (MHC class I chain-related gene A) is a polymorphic gene located 46 kb centromeric of the HLA-B gene, and is preferentially expressed in epithelial cells and intestinal mucosa...
  68. ncbi Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
    Helmut Rainer Salih
    Department of Internal Medicine II, University Hospital, Eberhard Karls University, Tubingen, Germany
    Blood 102:1389-96. 2003
    ..This led to the hypothesis that NKG2DLs play a critical role in tumor immune surveillance. The human NKG2DLs MICA and MICB are expressed on tumors of epithelial origin in vivo...
  69. ncbi Association of MICA polymorphism with rheumatoid arthritis patients in Koreans
    Jee Won Mok
    Department of Biology, Sungshin Women s University, Seoul, South Korea
    Hum Immunol 64:1190-4. 2003
    To investigate whether genetic variations of MICA are associated with susceptibility to rheumatoid arthritis (RA), the (GCT)n microsatellite polymorphism of the transmembrane domain was analyzed in 144 Korean patients with RA and in 297 ..
  70. ncbi Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences
    Yuta Kochi
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:63-71. 2004
    ..To examine the entire HLA region for loci (other than the DRB1 locus) associated with rheumatoid arthritis (RA) susceptibility, by typing HLA-DRB1 alleles and multiple single-nucleotide polymorphisms (SNPs) in the Japanese population...
  71. pmc Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D
    Konstantina Eleme
    Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
    J Exp Med 199:1005-10. 2004
    Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) ..
  72. pmc The increase of MICA gene A9 allele associated with gastric cancer and less schirrous change
    S S Lo
    I Lan Hospital, DOH, Taipei, Taiwan
    Br J Cancer 90:1809-13. 2004
    ..This family consists of five genes (A, B, C, D and E). Among them, MICA has five various alleles (A4, A5, A5...
  73. ncbi Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus
    G Gambelunghe
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Rheumatology (Oxford) 44:287-92. 2005
    To evaluate the contribution of the MHC class I chain-related A (MICA) gene polymorphism to the genetic risk of systemic lupus erythematosus (SLE).
  74. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
    ..Thus, the DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells...
  75. ncbi Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
    Katrin Wiemann
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Immunol 175:720-9. 2005
    ..persistent NKG2D ligand expression in vivo by using transgenic mice expressing MHC class I chain-related protein A (MICA) under control of the H2-K(b) promoter...
  76. ncbi Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas
    Masahisa Jinushi
    Department of Molecular Therapeutics, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 43:1013-20. 2005
    MHC class I-related chain A (MICA), a human ligand of natural killer (NK) cell stimulatory receptor NKG2D, is expressed in human hepatocellular carcinomas (HCC)...
  77. ncbi The identification of three novel MICA alleles by sequence-based typing
    I Quiroga
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Tissue Antigens 67:321-5. 2006
    During a study of MICA frequency in a healthy population and a cohort of patients suffering with inflammatory bowel disease, three DNA samples produced unusual reactivity patterns using polymerase chain reaction sequence-specific primers (..
  78. ncbi MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility
    R Lopez-Arbesu
    Department of Functional Biology, Universidad de Oviedo, Oviedo, Spain
    Rheumatology (Oxford) 46:426-30. 2007
    ..In this study, we investigate whether inhibitor of kappaB-like (IkappaBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.
  79. ncbi The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection
    B Suarez-Alvarez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Am J Transplant 7:1842-8. 2007
    The role of MICA antibodies in acute heart allograft rejection was examined utilizing 190 pre- and post-transplant serum samples from 44 patients collected during the first year after transplantation...
  80. pmc In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer
    Stéphanie Schrambach
    Laboratoire central d immunologie, pole de biologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France Service de Rhumatologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France Immunogénétique Moléculaire Humaine, Centre de Recherce d Immunologie et d Hématologie, Faculté de médecine Strasbourg, France
    PLoS ONE 2:e518. 2007
    ..In parallel, a total body tissue scan of both MICA and MICB transcription clearly shows that despite original presumptions, and with the exception of the central ..
  81. pmc Upregulation of MICA on high-grade invasive operable breast carcinoma
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections, Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, NG5 1PB, United Kingdom
    Cancer Immun 7:17. 2007
    The MHC class I chain-related gene A (MICA) is frequently expressed on the surface of intestinal epithelium and by many epithelial tumours...
  82. pmc MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma
    Masahisa Jinushi
    Department of Medical Oncology and Cancer Vaccine Center, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:1285-90. 2008
    ..an activating receptor on natural killer (NK) cells, CD8(+) T lymphocytes, and MHC class I chain-related protein A (MICA), an NKG2D ligand induced in malignant plasma cells through DNA damage, contribute to the pathogenesis of MGUS and ..
  83. pmc Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B
    Brian P McSharry
    Department of Medical Microbiology, Cardiff University, Tenovus Building, Heath Park, Cardiff CF14 4XX, United Kingdom
    J Virol 82:4585-94. 2008
    ..enhances synthesis of the NKG2D ligands, major histocompatibility complex class I chain-related proteins A and B (MICA and MICB), their expression on the cell surface is actively suppressed...
  84. doi Tumor-associated MICA is shed by ADAM proteases
    Inja Waldhauer
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Cancer Res 68:6368-76. 2008
    ..Here, we report that the prototypical NKG2DL MICA is released by proteolytic cleavage in the stalk of the MICA ectodomain, where deletions, but not alanine ..
  85. ncbi Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA
    Mercedes Kloss
    Department of Hematology, Eberhard Karls University of Tuebingen, Germany
    J Immunol 181:6711-9. 2008
    ..b>MICA expression was associated with CD80, MHC class I and MHC class II up-regulation, secretion of proinflammatory ..
  86. pmc Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer
    R Kopp
    Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Clin Immunol 29:545-54. 2009
    The major histocompatibility complex class I related A (MICA) and MICB molecules are ligands of NKG2D receptors on natural killer cells, gamma/delta T cells, and CD8ass T cells that mediate host antitumor immune response...
  87. doi MHC class I chain-related gene A transmembrane polymorphism in Spanish women with breast cancer
    R Lavado-Valenzuela
    Immunology Service, Carlos Haya Regional University Hospital, Malaga, Spain
    Tissue Antigens 74:46-9. 2009
    The NKG2D-major histocompatibility complex class I-related chain A (MICA) system plays a key role in the antitumoral immune response. We studied five alleles of a microsatellite in the MICA transmembrane region; one of which (MICA-A5...
  88. doi Herpes simplex virus infection downmodulates NKG2D ligand expression
    D Schepis
    Department of Microbiology, Tumor and Cell Biology and Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 69:429-36. 2009
    ..Total cellular MICA contents remained unchanged, suggesting masking, internalization or intracellular retention of MICA as possible ..
  89. doi Association of MICA gene polymorphisms with Chlamydia trachomatis infection and related tubal pathology in infertile women
    Bing Mei
    Department of Immunology, College of Basic Medical Sciences, Central South University, 88 Xiangya Road, Changsha 410008, China
    Hum Reprod 24:3090-5. 2009
    ..Major histocompatibility complex class I chain-related A (MICA) gene is highly polymorphic as a potential host genetic candidate...
  90. pmc NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    Omodele Ashiru
    Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Virol 83:12345-54. 2009
    ..UL142 is known to down-modulate surface expression of MHC class I-related chain A (MICA), which is a ligand of the activating NK receptor NKG2D...
  91. doi Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma
    Keisuke Kohga
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Res 69:8050-7. 2009
    MHC class I-related chain A (MICA) is a ligand for the NKG2D-activating immunoreceptor that mediates activation of natural killer (NK) cells...
  92. pmc The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells
    Leslie Elsner
    Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany
    J Cell Mol Med 14:992-1002. 2010
    ..human NK cells to kill target cells expressing major histocompatibility complex class I chain-related molecule A (MICA) in a natural killer group 2 member D (NKG2D-) dependent manner...
  93. doi Correlation of major histocompatibility complex class I related A (MICA) polymorphism with the risk of developing breast cancer
    Sadeq Vallian
    Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
    Med Oncol 29:5-9. 2012
    In the present study, we examined the association of different alleles of MICA gene with the risk of breast cancer development in Iranian population...
  94. doi Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
    Vinod Kumar
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Nat Genet 43:455-8. 2011
    ..We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1...
  95. doi Positive association of major histocompatibility complex class I chain-related gene A polymorphism with leukemia susceptibility in the people of Han nationality of Southern China
    Q Z Luo
    Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China
    Tissue Antigens 78:178-84. 2011
    To assess the potential contribution of major histocompatibility complex class I chain-related gene A (MICA) polymorphisms toward the pathogenesis of leukemia, 107 leukemia patients and 162 ethnically matched controls from Hunan province, ..
  96. pmc Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression
    Helle Jensen
    Laboratory of Immunology, Section of Biomedicine, Life, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e23023. 2011
    ..Here we show that VSV infection leads to a robust induction of MICA mRNA expression, however the subsequent surface expression is potently hindered...
  97. pmc Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region
    Zheng Gong
    Department of Immunology, College of Basic Medical Sciences, Central South University, 110 Xiangya Road, Changsha, Hunan Province, China
    Braz J Med Biol Res 45:222-9. 2012
    Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome...
  98. pmc Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma
    Vinod Kumar
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e44743. 2012
    MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress...
  99. doi Genome-wide association study of susceptibility loci for cervical cancer
    Dan Chen
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, 751 85 Uppsala, Sweden
    J Natl Cancer Inst 105:624-33. 2013
    ..Cervical carcinoma has a heritable genetic component, but the genetic basis of cervical cancer is still not well understood...
  100. pmc Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk
    Paulisally Hau Yi Lo
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e61279. 2013
    ..the association of SNP rs2596542 in the 5' flanking region of the MHC class I polypeptide-related sequence A (MICA) gene with the risk of HCV-induced HCC...
  101. pmc Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs
    Takahiro Kishikawa
    1 Department of gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan 2
    Sci Rep 3:2739. 2013
    ..of a single nucleotide polymorphism (SNP) at the promoter region of the MHC class I polypeptide-related sequence A (MICA) gene with the risk of hepatitis-virus-related HCC...

Research Grants2

  1. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  2. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..