MIB1

Summary

Gene Symbol: MIB1
Description: mindbomb E3 ubiquitin protein ligase 1
Alias: DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1, RING-type E3 ubiquitin transferase MIB1, ubiquitin ligase mind bomb, zinc finger ZZ type with ankyrin repeat domain protein 2
Species: human
Products:     MIB1

Top Publications

  1. Jin Y, Blue E, Dixon S, Shao Z, Gallagher P. A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. J Biol Chem. 2002;277:46980-6 pubmed
    ..These studies also demonstrate that DAPK is an in vitro and in vivo target for ubiquitination by DIP-1, thereby providing a mechanism by which DAPK activities can be regulated through proteasomal degradation. ..
  2. Itoh M, Kim C, Palardy G, Oda T, Jiang Y, Maust D, et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell. 2003;4:67-82 pubmed
    ..Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons...
  3. Yoo K, Kim E, Jung S, Rhee M, Koo B, Yoon K, et al. Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS Lett. 2006;580:4409-16 pubmed
    ..Taken together, we show that Snx5, a novel interacting partner of Mind bomb, may have an essential role for cell fate determination in early development. ..
  4. Villumsen B, Danielsen J, Povlsen L, Sylvestersen K, Merdes A, Beli P, et al. A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J. 2013;32:3029-40 pubmed publisher
    ..We demonstrate that the E3 ubiquitin ligase MIB1 is a new component of centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1 and suppresses ..
  5. Ram N, Rashid O, Farooq S, Ulhaq I, Islam N. Primary adrenal non-Hodgkin lymphoma: a case report and review of the literature. J Med Case Rep. 2017;11:108 pubmed publisher
    ..The patient's Ki-67 (Mib-1) index was approximately 80%...
  6. Endo Y, Kitago M, Miyajima A, Kurihara I, Kameyama K, Shinoda M, et al. Two-stage resection of a bilateral pheochromocytoma and pancreatic neuroendocrine tumor in a patient with von Hippel-Lindau disease: A case report. Int J Surg Case Rep. 2018;44:139-142 pubmed publisher
    ..Histopathological examination findings indicated NET G2 (MIB-1 index 10-15%) pT3N0M0 Stage II A and microcystic serous cystadenoma throughout the resected specimen...
  7. Mete O, Gomez Hernandez K, Kucharczyk W, Ridout R, Zadeh G, Gentili F, et al. Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas. Mod Pathol. 2016;29:131-42 pubmed publisher
    ..2 antibody; scattered fibrous bodies were noted in five (16%) tumors. The mean MIB-1 labeling index was 4% (range, 1-9%)...
  8. RUTLEDGE S, Harrison M, O Connell M, O Dwyer T, Byrne M. Acute presentation of a giant intrathyroidal parathyroid adenoma: a case report. J Med Case Rep. 2016;10:286 pubmed
    ..There was no definite infiltration of the capsule and MIB1 count was low at 1 % thus the specimen lacked the diagnostic features of carcinoma...
  9. Skálová A, Weinreb I, Hyrcza M, Simpson R, Laco J, Agaimy A, et al. Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol. 2015;39:338-48 pubmed publisher
    ..Immunohistochemically, the tumors expressed p63 (96%), cytokeratin CK14 (96%), and S100 protein (88%). MIB1 index varied from 10% to 100%, with most cases in the 20% to 40% range...

More Information

Publications131 found, 100 shown here

  1. Drueppel D, Schultheis B, Solass W, Ergonenc H, Tempfer C. Primary malignant melanoma of the breast: case report and review of the literature. Anticancer Res. 2015;35:1709-13 pubmed
    ..The tumor proliferation rate according to Mib1-staining was 90%. Staging of the abdomen, chest, head and bones showed no evidence of metastases...
  2. Zhou X, Zhang N, Xia L, Li Q, Shao J, Shen Q, et al. ResDE Two-Component Regulatory System Mediates Oxygen Limitation-Induced Biofilm Formation by Bacillus amyloliquefaciens SQR9. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Aguilar, H. Vlamakis, R. Losick, and R. Kolter, Curr Opin Microbiol 10:638-643, 2007, https://doi.org/10.1016/j.mib.2007.09.006; S. S. Branda, J. E. González-Pastor, S. Ben-Yehuda, R. Losick, and R...
  3. Gillespie D, Aguirre M, Ravichandran S, Leishman L, Berrondo C, Gamboa J, et al. RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J Neurosurg. 2015;122:331-41 pubmed publisher
    ..VEGF), glucose transporter 1 (GLUT-1), c-MET, and carbonic anhydrase-IX (CA-IX) and markers for cell growth (MIB-1 and microvascular density) were also significantly lower...
  4. Yamada S, Yamada Y, Kobayashi M, Hino R, Nawata A, Noguchi H, et al. Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome. Diagn Pathol. 2014;9:197 pubmed publisher
    ..endothelial cells were strongly positive for lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 as well, and MIB-1 labeling index was less than 1%. Therefore, we finally made a diagnosis of BL of the skin...
  5. Biswas A, Julka P, Bakhshi S, Suri A, Rath G. Intracranial atypical teratoid rhabdoid tumor: current management and a single institute experience of 15 patients from north India. Acta Neurochir (Wien). 2015;157:589-96 pubmed publisher
    ..0149), use of craniospinal radiation (p = 0.0087), and MIB1 labeling index (p = 0...
  6. Wakasaki T, Kubota M, Nakashima Y, Tomonobe E, Mihara T, Fukushima J. Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports. BMC Cancer. 2016;16:827 pubmed
    ..Because of several high-risk factors for metastasis (i.e., invasive carcinoma ex PA, high MIB1 index, and mutant p53 protein positivity), radiotherapy and chemotherapy were recommended as adjuvant therapy...
  7. Inoue A, Ohnishi T, Kohno S, Nishikawa M, Nishida N, Ohue S. Role of Denosumab in Endoscopic Endonasal Treatment for Juvenile Clival Giant Cell Tumor: A Case Report and Review of the Literature. World Neurosurg. 2016;91:674.e1-6 pubmed publisher
    ..The giant cells showed positive immunostaining for CD68 and Mib-1 labeling index was less than 1.0%...
  8. Zejun D, Kun Y, Dehong L, Xueling Q. Proximal-Type Epithelioid Sarcoma in Skull Base: a Pathological Diagnosis Challenge with Other Intracranial Tumors. Pathol Oncol Res. 2019;25:201-208 pubmed publisher
    ..Besides, TP53 positive cells were observed (>50%) in the two cases. The MIB-1 proliferation index was high up to 50-70%...
  9. Nahed B, Redjal N, Brat D, Chi A, Oh K, Batchelor T, et al. Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015;125:609-30 pubmed publisher
    ..PROLIFERATIVE INDEX AND RECURRENCE: (Level III) It is recommended that proliferative indices (MIB-1 or BUdR) be measured in LGGs as higher proliferation indices are associated with increased likelihood of ..
  10. Simmons M, Morales C, Oakley B, Seal B. Recombinant Expression of a Putative Amidase Cloned from the Genome of Listeria monocytogenes that Lyses the Bacterium and its Monolayer in Conjunction with a Protease. Probiotics Antimicrob Proteins. 2012;4:1-10 pubmed publisher
    ..monocytogenes strain as well as other strains of the bacterium in spot and MIC/MIB assays, but was not active against other bacteria beyond the genus...
  11. Yoon C, Choi Y, Cha Y, Koh S, Choi J, Kim T, et al. Diabetes-Induced Jagged1 Overexpression in Endothelial Cells Causes Retinal Capillary Regression in a Murine Model of Diabetes Mellitus: Insights Into Diabetic Retinopathy. Circulation. 2016;134:233-47 pubmed publisher
    ..using chemical inhibitors in wild-type mice or transgenic mice, inducing conditional knockout of Jagged1 or Mib1. DMV was characterized by capillary remodeling, regression, and decreased density...
  12. Surov A, Meyer H, Höhn A, Winter K, Sabri O, Purz S. Associations Between [18F]FDG-PET and Complex Histopathological Parameters Including Tumor Cell Count and Expression of KI 67, EGFR, VEGF, HIF-1α, and p53 in Head and Neck Squamous Cell Carcinoma. Mol Imaging Biol. 2019;21:368-374 pubmed publisher
    ..In all cases, whole body PET was performed. For this study, the following specimen stainings were performed: MIB-1 staining (KI 67 expression), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), ..
  13. Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou H, et al. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. MBio. 2018;9: pubmed publisher
    ..2017.120; E. J. Sontheimer and A. R. Davidson, Curr Opin Microbiol 37:120-127, 2017, https://doi.org/10.1016/j.mib.2017.06.003)...
  14. Nausch H, Broer I. Cyanophycinase CphE from P. alcaligenes produced in different compartments of N. benthamiana degrades high amounts of cyanophycin in plant extracts. Appl Microbiol Biotechnol. 2017;101:2397-2413 pubmed publisher
    ..Due to the high and robust enzyme activity, even moderate CphE concentrations were sufficient to degrade CGP in plant extracts. ..
  15. Carozzi F, Tamburrino L, Bisanzi S, Marchiani S, Paglierani M, Di Lollo S, et al. Are biomarkers evaluated in biopsy specimens predictive of prostate cancer aggressiveness?. J Cancer Res Clin Oncol. 2016;142:201-12 pubmed publisher
    ..and 9 (epithelial and stromal); (3) expression of androgen receptor; (4) expression of prognostic marker Ki67 (MIB1); (5) presence and typing of human papilloma virus; (6) DNA methylation of CpG islands of several genes involved in ..
  16. Kamboj M, Gandhi J, Gupta G, Sharma A, Pasricha S, Mehta A, et al. Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature. J Gastrointest Cancer. 2015;46:356-64 pubmed publisher
    ..in terms of survival and to segregate NECs into further subcategories, that is 20-50 % and >50 %, based on MIB-1 index. We retrospectively searched the clinical and pathological database over 2...
  17. Chen F, Jin R, Wu X, Dong Z, Chen D. Extraventricular Neurocytoma in the Left Frontal Lobe: A Case Report and Literature Review. World Neurosurg. 2018;112:178-181 pubmed publisher
    ..Immunohistochemical staining showed diffuse positivity for synaptophysin. MIB-1 staining for Ki-67 antibody showed a labeling index of 20%...
  18. Filippova E, Zemaitaitis B, Aung T, Wolfe A, Anderson W. Structural Basis for DNA Recognition by the Two-Component Response Regulator RcsB. MBio. 2018;9: pubmed publisher
    ..J. Wolfe, Curr Opin Microbiol 13:204-209, 2010, https://doi.org/10.1016/j.mib.2010.01.002; D. J. Clarke, Future Microbiol 5:1173-1184, 2010, https://doi.org/10.2217/fmb.10.83)...
  19. Yamanaka Y, Menuki K, Zenke Y, Hirasawa H, Sakai A. Enhanced expression of Wnt9a in the flexor tenosynovium in idiopathic carpal tunnel syndrome. J Orthop Res. 2015;33:1531-6 pubmed publisher
    ..In addition, we compared the Wnt and MIB-1 protein expression levels to clarify the effect of Wnt on cell proliferation...
  20. Wilson A, Saskowski J, Barham W, YULL F, Khabele D. Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer. J Ovarian Res. 2015;8:46 pubmed publisher
    ..assay); protein expression of the double-strand DNA break marker, pH2AX(ser139), the proliferation markers, Ki67/mib-1 and PCNA, and the apoptosis markers, cleaved caspase-3, cleaved PARP and Bax; and mRNA expression of NF-?B ..
  21. Iobagiu C, Lambert C, Raica M, Lima S, Khaddage A, Peoc h M, et al. Loss of heterozygosity in tumor tissue in hormonal receptor genes is associated with poor prognostic criteria in breast cancer. Cancer Genet. 2015;208:135-42 pubmed publisher
    ..007), PR-negative status (P = 0.003), high Scarff-Bloom-Richardson (SBR) grade (P = 0.0007), high MIB-1 proliferation index (P = 0.02), and diminished apoptosis potential (TP53-positive status, P = 0.018)...
  22. Hortopan G, Baraban S. Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish. Dev Dyn. 2011;240:1964-76 pubmed publisher
    ..Using mib(hi904) zebrafish, we reported seizures and a down-regulation of γ-aminobutyric acid (GABA) signaling pathway genes...
  23. Nagano H, Izumi T, Kawahara E, Oyama T, Goi T. SMARCB1- and vimentin-positive esophageal carcinoma with undifferentiated components, rhabdoid features, and a good prognosis: a case report. Surg Case Rep. 2019;5:8 pubmed publisher
    ..The MIB-1 index was 19.7% and 0...
  24. Otten T, Graham J, Harris T, Dreher T. Elucidation of Taste- and Odor-Producing Bacteria and Toxigenic Cyanobacteria in a Midwestern Drinking Water Supply Reservoir by Shotgun Metagenomic Analysis. Appl Environ Microbiol. 2016;82:5410-20 pubmed publisher
    ..of the order Oscillatoriales as the likely principal producers of geosmin, microcystin, and 2-methylisoborneol (MIB), respectively...
  25. Collaud S, Tischler V, Atanassoff A, Wiedl T, Komminoth P, Oehlschlegel C, et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC Cancer. 2015;15:74 pubmed publisher
    ..data including overall survival, proliferation rate and diagnostic markers (synaptophysin, chromogranin A, Mib-1, TTF-1) were recorded...
  26. Soliman W. Ventricular Central Neurocytoma: Rate of Shunting and Outcome 2 Years After Total and Subtotal Excision. Acta Neurochir Suppl. 2017;124:179-185 pubmed publisher
    ..External Ventricular Drain (EVD) was inserted then removed or replaced by a shunt. Histopathology and the MIB index were used to confirm diagnosis and guide the follow-up; adjuvant radiotherapy or Gamma Knife radiosurgery ..
  27. Hodge R, Mandle H, Ray S, Tandon S, Peterson M, Henry A, et al. Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients. Cancer Prev Res (Phila). 2018;11:707-716 pubmed publisher
    ..adenomas, high red/processed meat intake, and high levels of rectal epithelial cell proliferation (as measured by MIB-1/Ki-67), were associated with higher baseline expression of TLRs or pIKKα/β...
  28. Cahill D, Sloan A, Nahed B, Aldape K, Louis D, Ryken T, et al. The role of neuropathology in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015;125:531-49 pubmed publisher
    ..In adult patients (age ≥18 years) with histologically-proven WHO grade II diffuse glioma, is Ki-67/MIB1 immunohistochemistry warranted? If so, is there a preferred method to quantitate results? Ki67/MIB1 ..
  29. Moriya J, Tanino M, Takenami T, Endoh T, Urushido M, Kato Y, et al. Rapid immunocytochemistry based on alternating current electric field using squash smear preparation of central nervous system tumors. Brain Tumor Pathol. 2016;33:13-8 pubmed publisher
    ..using AC electric field that takes only 22 min, and demonstrated its usefulness for semi-quantitative Ki-67/MIB-1 labeling index and CD 20 by R-ICC for intraoperative diagnosis...
  30. Och W, Kulbacki K, Szostak B, Sikorska B, Zakrzewska M, Szmuda T, et al. The molecular pattern of histopathological progression to anaplastic meningioma - A case report. Neurol Neurochir Pol. 2016;50:288-93 pubmed publisher
    ..Additionally, such biomarkers as Ki-67/MIB-1, progesterone receptors and phosphor-histone H3 were correlated with MG progression...
  31. Luxan G, Casanova J, Martínez Poveda B, Prados B, D Amato G, MacGrogan D, et al. Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med. 2013;19:193-201 pubmed publisher
    ..We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin ligase that promotes endocytosis of the NOTCH ligands DELTA and ..
  32. Yoshidaya F, Hayashi N, Takahashi K, Suzuki K, Akiyama F, Ishiyama M, et al. Malignant phyllodes tumor metastasized to the right ventricle: a case report. Surg Case Rep. 2015;1:121 pubmed publisher
    ..smooth muscle lineage including α-smooth muscle actin and Calponin1 and highly malignant characteristics showing MIB-1 and p53 highly positive with angiogenesis...
  33. Angulo J, Redondo C, Sanchez Chapado M, Colás B, Ropero S, Lopez J. Survival predictors in patients with prostate adenocarcinoma with hormonal blockade. Pathol Res Pract. 2016;212:899-903 pubmed publisher
    ..We assessed the Gleason index, performed an immunohistochemical analysis of Ki-67 (MIB-1) and determined the presence of neuroendocrine differentiation (chromogranin A)...
  34. Lopez Pinar A, Ghadiriasli R, Darriet P, Buettner A. Unexpected impact of 2-methylisoborneol as off-odour substance in aged wines. Food Chem. 2017;220:498-504 pubmed publisher
    ..2-Methylisoborneol (2-MIB) was detected in two of these wines, although the samples were seven years old, contradicting previous reports that ..
  35. Huynen M, Mühlmeister M, Gotthardt K, Guerrero Castillo S, Brandt U. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Biochim Biophys Acta. 2016;1863:91-101 pubmed publisher
    ..site and cristae organizing system (MICOS) complex proteins and mitochondrial intermembrane space bridging complex (MIB) proteins over (sub)complexes and over species...
  36. Yan R, Haopeng P, Xiaoyuan F, Jinsong W, Jiawen Z, Chengjun Y, et al. Non-Gaussian diffusion MR imaging of glioma: comparisons of multiple diffusion parameters and correlation with histologic grade and MIB-1 (Ki-67 labeling) index. Neuroradiology. 2016;58:121-32 pubmed publisher
    ..of Gaussian and non-Gaussian magnetic resonance imaging (MRI)-derived parameters with histologic grade and MIB-1 (Ki-67 labeling) index (MI) in brain glioma...
  37. Oliva E, Soslow R. High-Grade Endometrial Carcinomas. Surg Pathol Clin. 2011;4:199-241 pubmed publisher
    ..Immunohistochemical stains for p53, p16, ER, PR, mib-1, hepatocyte nuclear factor 1β and pan-cytokeratin can be helpful in classifying these high-grade carcinomas...
  38. Breyer J, Wirtz R, Otto W, Erben P, Kriegmair M, Stoehr R, et al. In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival. Virchows Arch. 2017;470:267-274 pubmed publisher
    ..Furthermore, immunohistochemical (IHC) staining of CK20, panCK, and MIB1 was performed. Valid measurements were obtained from 231 samples out of a series of 284 patients...
  39. Winther T, Torp S. DNA topoisomerase IIα and mitosin expression predict meningioma recurrence better than histopathological grade and MIB-1 after initial surgery. PLoS ONE. 2017;12:e0172316 pubmed publisher
    The 2016 WHO histopathological grade or conventional biomarker MIB-1 is insufficient for predicting meningioma recurrence after initial treatment and alternative strategies are required...
  40. Comandini D, Damiani A, Pastorino A. Synchronous GISTs associated with multiple sporadic tumors: a case report. Drugs Context. 2017;6:212307 pubmed publisher
    ..a slight difference in lymphoid infiltration, the abdominal and gastric GIST nodules shared the same proliferative MIB1 index and mitotic count...
  41. Bartova M, Ondrias F, Muy Kheng T, Kastner M, Singer C, Pohlodek K. COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. Bratisl Lek Listy. 2014;115:445-51 pubmed
    ..This fact might be useful in the evaluation of further behaviour of early breast tumors (Tab. 3, Fig. 8, Ref. 29). ..
  42. Ryu J, Kong H, Park J, Lim K, An C, Lee J, et al. Generation of late-born neurons in the ventral spinal cord requires the coordination of retinoic acid and Notch signaling. Neurosci Lett. 2015;602:95-8 pubmed publisher
    ..We investigated the role of Mindbomb (Mib)-mediated Notch signaling in the differentiation of neural progenitors during late neurogenesis by overexpressing ..
  43. Keller K, Rodríguez López S, Carmenate Moreno M. Association between meal intake behavior and blood pressure in Spanish adults. Nutr Hosp. 2017;34:654-660 pubmed publisher
    ..Yet, the results are inconclusive, possibly because eating frequency, particularly meal intake behavior (MIB), does not differentiate between meals and snacks...
  44. Tripathy K, Das B, Singh A, Misra A, Misra S, Misra S. Prognostic Significance of Epidermal Growth Factor Receptor in Patients of Glioblastoma Multiforme. J Clin Diagn Res. 2017;11:EC05-EC08 pubmed publisher
    ..of rampant proliferation of glial cells along with high pleomorphism, necrosis, endothelial proliferation and high MIB-1 labeling index (cell proliferation marker)...
  45. Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, et al. A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition. Cancer Cell Int. 2016;16:35 pubmed publisher
    ..the treatment with both YS110 and PMX inhibited in vivo tumor growth accompanied by a synergistic reduction in the MIB-1 index...
  46. Ctori I, Huntjens B. The Association between Foveal Morphology and Macular Pigment Spatial Distribution: An Ethnicity Study. PLoS ONE. 2017;12:e0169520 pubmed publisher
    ..8° retinal eccentricity) or foveal width between MP profile groups (P>0.05). We report a significant difference in the amount and distribution of MP between ethnicities that is not explained by variations in foveal morphology. ..
  47. Cramer S, Oshri A, Heller D. A Study of Myometrial Growth and Development. J Pediatr Adolesc Gynecol. 2015;28:387-94 pubmed publisher
    ..Most were embedded in toto, with 1 block and 1 slide per case. Some were immunostained for actin, CD10, MIB-1, and/or trichrome stain for collagen and muscle...
  48. McDiarmid A, Ripley D, Mohee K, Kozerke S, Greenwood J, Plein S, et al. Three-dimensional whole-heart vs. two-dimensional high-resolution perfusion-CMR: a pilot study comparing myocardial ischaemic burden. Eur Heart J Cardiovasc Imaging. 2016;17:900-8 pubmed publisher
    ..This study aims to compare image quality, diagnostic confidence, and quantitation of myocardial ischaemic burden (MIB) between 2D high-resolution and 3D whole-heart perfusion-CMR...
  49. Liu C, Sun Y, Wang D, Sun Z, Chen M, Zhou Z, et al. Performance and mechanism of low-frequency ultrasound to regenerate the biological activated carbon. Ultrason Sonochem. 2017;34:142-153 pubmed publisher
    ..removal efficiencies of regenerated BAC were still high for the removal of organic contaminants, atrazine, and 2-MIB. Analysis of pore structure, BET surface area, and scanning electron microscopy indicated that ultrasound mainly ..
  50. Kar S, Bali K, Baisantry A, Geffers R, Samii A, Bertalanffy H. Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations. J Mol Neurosci. 2017;61:178-188 pubmed publisher
    ..in silico analyses revealed that the prioritized miRNAs have a direct functional relation with mRNAs, such as MIB1, HIF1A, PDCD10, TJP1, OCLN, HES1, MAPK1, VEGFA, EGFL7, NF1, and ENG, which are previously characterized as key ..
  51. Sturgeon M, Davis D, Albers A, Beatty D, Austin R, Ferguson M, et al. The Notch ligand E3 ligase, Mind Bomb1, regulates glutamate receptor localization in Drosophila. Mol Cell Neurosci. 2016;70:11-21 pubmed publisher
    ..We identified the E3 ubiquitin ligase, Mib1, which promotes Notch signaling, as a regulator of synaptic GluR localization...
  52. Kiesel B, Mischkulnig M, Woehrer A, Martinez Moreno M, Millesi M, Mallouhi A, et al. Systematic histopathological analysis of different 5-aminolevulinic acid-induced fluorescence levels in newly diagnosed glioblastomas. J Neurosurg. 2017;:1-13 pubmed publisher
    ..nuclear pleomorphism, mitotic activity, and presence of microvascular proliferation/necrosis), proliferation rate (MIB-1 labeling index [LI]), and microvessel density (using CD34 staining) were investigated...
  53. Akimov V, Rigbolt K, Nielsen M, Blagoev B. Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. Mol Biosyst. 2011;7:3223-33 pubmed publisher
    ..we found two centrosomal proteins, PCM1 and Azi1, to form a multi-protein complex with the ubiquitin E3 ligases MIB1 and WWP2 downstream of the EGFR, thereby revealing possible ubiquitination cross-talk between EGF signaling and ..
  54. Imamura H, Ohishi Y, Aman M, Shida K, Shinozaki T, Yasutake N, et al. Ovarian high-grade serous carcinoma with a noninvasive growth pattern simulating a serous borderline tumor. Hum Pathol. 2015;46:1455-63 pubmed publisher
    ..most HG-noninv showed aberrant p53 expression, frequent IMP3 positivity, p16 overexpression, a high MIB-1 labeling index, and infrequent PAX2...
  55. Wang Y, Wang Y, Wei L, Hong S, Zhao M, Zhang X, et al. BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions. J Ovarian Res. 2017;10:12 pubmed publisher
    ..Benign ovaries from 95 patients were examined. Dual immunohistochemical staining for both BRCA1 and MIB-1 were performed to examine the relationship between BRCA1 and MIB-1 in OEI cells...
  56. Sheu S, Liu L, Chen W. Flectobacillus pallidus sp. nov., isolated from a freshwater spring. Int J Syst Evol Microbiol. 2017;67:1126-1132 pubmed publisher
    ..2?% 16S rRNA gene sequence similarity) and Flectobacillus fontis MIB-4T (97.4?%)...
  57. Sadashiva N, Poyuran R, Mahadevan A, Bhat D, Somanna S, Devi B. Chordoid meningioma: a clinico-pathological study of an uncommon variant of meningioma. J Neurooncol. 2018;137:575-582 pubmed publisher
    ..Lymphoplasmacytic infiltrates were seen in 23 cases with majority being T cells. MIB index varied from 1 to 14%. Five patients received radiotherapy for residual lesion...
  58. Blank A, Wehweck L, Marinoni I, Boos L, Bergmann F, Schmitt A, et al. Interlaboratory variability of MIB1 staining in well-differentiated pancreatic neuroendocrine tumors. Virchows Arch. 2015;467:543-50 pubmed publisher
    Neuroendocrine tumors (NET) are routinely graded and staged to judge prognosis. Proliferation index using MIB1 staining has been introduced to assess grading...
  59. Gschwantler Kaulich D, Tan Y, Fuchs E, Hudelist G, Kostler W, Reiner A, et al. PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer. PLoS ONE. 2017;12:e0172911 pubmed publisher
    ..041), while there was no association with grading, hormone receptor status, IGFR or MIB. We found significantly more cases with progressive disease under trastuzumab-based therapy in patients with PTEN ..
  60. Chiaramonte C, Rabaste S, Jacquesson T, Meyronet D, Cotton F, Jouanneau E, et al. Liponeurocytoma of the Cerebellopontine Angle. World Neurosurg. 2018;112:18-24 pubmed publisher
    ..Treatment relies on total removal whenever possible, with an excellent prognosis, but a high MIB-1 index (>10%) and/or incomplete tumor resection are the main adverse prognostic factors.
  61. Zhang L, Nephew K, Gallagher P. Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. J Biol Chem. 2007;282:11795-804 pubmed
    ..Expression of two distinct ubiquitin E3 ligases, carboxyl terminus of HSC70-interacting protein (CHIP) or DIP1/Mib1, enhanced DAPK degradation, and conversely, short interfering RNA depletion of either CHIP or DIP1/Mib1 ..
  62. Varughese R, Lind Landström T, Habberstad A, Salvesen Ã, Haug C, Sundstrøm S, et al. Mitosin and pHH3 predict poorer survival in astrocytomas WHO grades II and III. J Clin Pathol. 2016;69:26-34 pubmed publisher
    ..H3 (pHH3) in infiltrative astrocytomas WHO grades II and III and compare the findings with mitotic count and Ki-67/MiB-1 immunostaining...
  63. Li H, Zhao M, Jiao Y, Li Z, Ma J, Wang S, et al. Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. Childs Nerv Syst. 2017;33:239-248 pubmed publisher
    ..Gross total resection was achieved in five patients. Of the six tumors with immunohistochemical records, MIB-1 labeling index varied from 3 to 20 % (mean 8.1 %). During the follow-up period (mean 76...
  64. Harada T, Kosaka S, Elliesen J, Yasuda M, Ito M, Momoeda M. Ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen for the management of endometriosis-associated pelvic pain: a randomized controlled trial. Fertil Steril. 2017;108:798-805 pubmed publisher
    ..and safety of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen (FlexibleMIB) compared with placebo to treat endometriosis-associated pelvic pain (EAPP)...
  65. Tarkang P, Okalebo F, Siminyu J, Ngugi W, Mwaura A, Mugweru J, et al. Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants. BMC Complement Altern Med. 2015;15:174 pubmed publisher
    Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves)...
  66. Liu L, Liu T, Ran Y, Li Y, Zhang X, Shu H, et al. The E3 ubiquitin ligase MIB1 negatively regulates basal I?B? level and modulates NF-?B activation. Cell Res. 2012;22:603-6 pubmed publisher
  67. Aleskandarany M, Green A, Ashankyty I, Elmouna A, Diez Rodriguez M, Nolan C, et al. Impact of intratumoural heterogeneity on the assessment of Ki67 expression in breast cancer. Breast Cancer Res Treat. 2016;158:287-95 pubmed publisher
    ..The immunohistochemical (IHC) expression of anti-Ki67 antibody (MIB1 clone) was assessed in four full-face (FF) sections from different primary tumour blocks and their matched axillary ..
  68. Thomas V, Davidson M, Zakavi P, Tsuchiya N, van Boxtel J. Simulated forward and backward self motion, based on realistic parameters, causes motion induced blindness. Sci Rep. 2017;7:9767 pubmed publisher
    Motion Induced Blindness (MIB) is a well-established visual phenomenon whereby highly salient targets disappear when viewed against a moving background mask...
  69. Tanaka K, Sakakima H, Hida K, Hatanaka K, Ijiri K. A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. Case Rep Orthop. 2017;2017:3284131 pubmed publisher
    ..In this report, we present that piecemeal spondylectomy is an alternative management for aged patients with cervical chordoma, even for those with high MIB-1 index.
  70. Henshall D, Schindler C, So N, Lan J, Meller R, Simon R. Death-associated protein kinase expression in human temporal lobe epilepsy. Ann Neurol. 2004;55:485-94 pubmed
    ..This study provides the first description of DAP kinase and DIP-1 in human brain and suggests DAP kinase is a novel molecular regulator of neuronal death in epilepsy. ..
  71. Joachim J, Razi M, Judith D, Wirth M, Calamita E, Encheva V, et al. Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy. Curr Biol. 2017;27:2123-2136.e7 pubmed publisher
    ..GABARAP instability is mediated through the centriolar satellite E3 ligase Mib1, which interacts with GABARAP through its substrate-binding region and promotes K48-linked ubiquitination of ..
  72. Winther T, Torp S. The anti-apoptotic protein survivin can improve the prognostication of meningioma patients. PLoS ONE. 2017;12:e0185217 pubmed publisher
    ..of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence ..
  73. Artico M, Bronzetti E, Alicino V, Ionta B, Bosco S, Grande C, et al. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Eur J Histochem. 2010;54:e10 pubmed
    ..We also investigated the expression of some known tumor markers such as MIB-1 (anti Ki-67), CD34 and CA15-3, to identify a possible correlation between the expression of these molecular ..
  74. Winther T, Torp S. MCM7 expression is a promising predictor of recurrence in patients surgically resected for meningiomas. J Neurooncol. 2017;131:575-583 pubmed publisher
    ..While the World Health Organization (WHO) classification and the MIB-1 biomarker are applied in the clinical practice to identify these patients, the reliability of these methods is ..
  75. Piccolo P, Attanasio S, Secco I, Sangermano R, Strisciuglio C, Limongelli G, et al. MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy. Hum Mol Genet. 2017;26:33-43 pubmed publisher
    ..Because mutations of MIB1, the homolog of MIB2, have been found in patients with left ventricle non-compaction (LVNC), we investigated ..
  76. Bähr O, Gross S, Harter P, Kirches E, Mawrin C, Steinbach J, et al. ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors. Oncol Lett. 2017;14:5443-5451 pubmed publisher
    ..tumor tissue were analyzed using conventional and immunohistochemical staining techniques [hematoxylin and eosin, MIB-1 antibody/proliferation maker protein Ki-67, cleaved caspase-8, stimulator of interferon genes (STING), ionized ..
  77. Kamal M, Pawlak A, Benmohamed F, Valanciute A, Dahan K, Candelier M, et al. C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase. FEBS Lett. 2010;584:500-6 pubmed publisher
    ..We demonstrate that c-mip interacts with Dip1 and upregulates DAPK, which blocks the nuclear translocation of ERK1/2...
  78. Guo B, McMillan B, Blacklow S. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol. 2016;41:38-45 pubmed publisher
    ..In mammals, this ubiquitination step is dependent on the protein Mind bomb 1 (Mib1), a large multi-domain RING-type E3 ligase, and its direct interaction with the intracellular tails of Notch ligand ..
  79. Berndt N, Seib E, Kim S, Troost T, Lyga M, Langenbach J, et al. Ubiquitylation-independent activation of Notch signalling by Delta. elife. 2017;6: pubmed publisher
    Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling...
  80. Onishi K, Kamida T, Momii Y, Abe T, Fujiki M. The clinical and pathological significance of nitric oxide synthase in human pituitary adenomas: a comparison with MIB-1. Endocrine. 2014;46:154-9 pubmed publisher
    ..of nitric oxide synthase (NOS) in human pituitary adenomas, and to compare these values with those of the MIB-1 labeling index (LI) using an immunohistochemical method...
  81. Miyabe S, Okabe M, Nagatsuka H, Hasegawa Y, Inagaki A, Ijichi K, et al. Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. J Oral Maxillofac Surg. 2009;67:1432-41 pubmed publisher
    ..For disease-free survival, p27Kip1 might be the most useful prognostic factor. In contrast, Ki-67 might not be a very powerful prognostic indicator for either survival point. ..
  82. Zhang L, Widau R, Herring B, Gallagher P. Delta-like 1-Lysine613 regulates notch signaling. Biochim Biophys Acta. 2011;1813:2036-43 pubmed publisher
    ..Collectively these results suggest that the transcellular defect in Notch signaling attributed to residue K613 in cytoplasmic tail of Dll1 may result from altering its multi-ubiquitination and increasing its retention in lipid rafts. ..
  83. Nishioka H, Hara T, Nagata Y, Fukuhara N, Yamaguchi Okada M, Yamada S. Inherent Tumor Characteristics That Limit Effective and Safe Resection of Giant Nonfunctioning Pituitary Adenomas. World Neurosurg. 2017;106:645-652 pubmed publisher
    ..Most tumors were histologically benign, with a low MIB-1 index (<3.0%) beside a few tumors mainly silent adenomas of pituitary-specific transcription factor lineage...
  84. Xiao X, Zhou J, Wang J, Yang L, Wang C, Xu Y, et al. Clinical, radiological, pathological and prognostic aspects of intraventricular oligodendroglioma: comparison with central neurocytoma. J Neurooncol. 2017;135:57-65 pubmed publisher
    ..000), Syn (p?=?0.01) and NeuN (p?=?0.000) were observed. In addition, MIB-1 labeling index (p?=?0.035) and case fatality rate (p?=?0...
  85. Miyaoka M, Kikuti Y, Carreras J, Ikoma H, Hiraiwa S, Ichiki A, et al. Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements. Mod Pathol. 2017;: pubmed publisher
    ..There was significant difference in MYC intensity (P=0.00004) and MIB-1 positivity (P=0...
  86. Lai K, Li J, Hsu C, You M, Chan T, Tse W, et al. Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish. Gene. 2018;642:51-57 pubmed publisher
    b>mibnn2002, identified from an allele screen, shows early segmentation defect and severe cell death phenotypes, which are different from those of other described mib mutant alleles...
  87. Mastronardi L, Guiducci A, Spera C, Puzzilli F, Liberati F, Ruggeri A, et al. Adrenocorticotropic hormone secreting pituitary adenomas: analysis of growth fraction using the MIB-1 antibody. Tumori. 2000;86:229-32 pubmed
    ..Ki-67 is a nuclear antigen which is easily detectable by means of the MIB-1 monoclonal antibody, and the labeling index (LI) obtained can be considered a marker of tumor proliferation.
  88. Wang Z, Tseng C, Pong R, Chen H, McConnell J, Navone N, et al. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem. 2002;277:12622-31 pubmed
    ..We describe the cloning of DIP1/2, a novel gene that interacts with the N-terminal domain of DOC-2/DAB2...
  89. Guerini F, Bolognesi E, Manca S, Sotgiu S, Zanzottera M, Agliardi C, et al. Family-based transmission analysis of HLA genetic markers in Sardinian children with autistic spectrum disorders. Hum Immunol. 2009;70:184-90 pubmed publisher
    ..In particular, four microsatellites (MIB, D6S265, MOGc, and D6S2239) and three single-nucleotide polymorphisms (SNPs; two in positions -308 and -238 in the ..
  90. Čajánek L, Glatter T, Nigg E. The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis. J Cell Sci. 2015;128:1674-82 pubmed publisher
    ..Here, we identify the E3 ubiquitin ligase Mind bomb (Mib1) as a new interaction partner of Plk4...
  91. Wang L, Lee K, Malonis R, SANCHEZ I, Dynlacht B. Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. elife. 2016;5: pubmed publisher
    ..Remarkably, we find that PCM1 is essential for tethering the E3 ligase, Mindbomb1 (Mib1), to satellites...
  92. Li R, Xu J, Li X, Shi Z, Harrison P. Spatiotemporal Variability in Phosphorus Species in the Pearl River Estuary: Influence of the River Discharge. Sci Rep. 2017;7:13649 pubmed publisher
    ..37??M in May and 0.56?±?0.42??M in August at the surface. Additionally, stratification restricted the bottom phosphorus replenishment. Our findings provided an insight into processes causing stoichiometric P limitation in the PRE. ..