MGAT1

Summary

Gene Symbol: MGAT1
Description: mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Alias: GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI, MGAT, alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, glcNAc-T I
Species: human
Products:     MGAT1

Top Publications

  1. Kumar R, Yang J, Larsen R, Stanley P. Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. Proc Natl Acad Sci U S A. 1990;87:9948-52 pubmed
    ..Northern blot analysis with the same probe showed that Lec1 mutant cells also possessed an approximately 2.7-kb poly(A)+ RNA, indicating that the lec1 mutation is a point mutation. ..
  2. Yip B, Chen S, Mulder H, Hoppener J, Schachter H. Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. Biochem J. 1997;321 ( Pt 2):465-74 pubmed
    ..Previous work indicated the presence of at least two exons in the human GlcNAc-T I gene MGAT1, exon 2 containing part of the 5' untranslated region and the complete coding and 3' untranslated regions, and ..
  3. Johansson A, Marroni F, Hayward C, Franklin C, Kirichenko A, Jonasson I, et al. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. Obesity (Silver Spring). 2010;18:803-8 pubmed publisher
    ..3 x 10(-8)) was associated with weight, whereas none with BMI. The SNP associated with weight is located close to MGAT1. The monoacylglycerol acyltransferase (MGAT) enzyme family is known to be involved in dietary fat absorption...
  4. Alsanea S, Gao M, Liu D. Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. AAPS J. 2017;19:797-805 pubmed publisher
    ..peroxisome proliferator-activated receptor-γ 2 (Pparγ2), and its target monoacylglycerol O-acyltransferase (Mgat-1) genes...
  5. Priyambada S, Misaki R, Okamoto T, Okamoto Y, Ohashi T, Ueda K, et al. Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus. Virus Res. 2017;238:101-109 pubmed publisher
    ..Altogether, the results show that HBV expression triggered the alteration of the cell surface N-glycosylation pattern and the expression levels of glycosyltransferases of HepAD38 cells. ..
  6. Woodward A, Lehoux S, Mantelli F, Di Zazzo A, Brockhausen I, Bonini S, et al. Inflammatory Stress Causes N-Glycan Processing Deficiency in Ocular Autoimmune Disease. Am J Pathol. 2019;189:283-294 pubmed publisher
  7. Deminice R, da Silva R, Lamarre S, Kelly K, Jacobs R, Brosnan M, et al. Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. Amino Acids. 2015;47:839-46 pubmed publisher
    ..It was accompanied by the normalization of the gene expression of BHMT, GNMT and MGAT, which code for key enzymes of one-carbon metabolism related to liver fat accumulation...
  8. De Luca C, Savarese L, Colangelo A, Bianco M, Cirillo G, Alberghina L, et al. Astrocytes and Microglia-Mediated Immune Response in Maladaptive Plasticity is Differently Modulated by NGF in the Ventral Horn of the Spinal Cord Following Peripheral Nerve Injury. Cell Mol Neurobiol. 2016;36:37-46 pubmed publisher
    ..The gliosis was associated with the reduction of glial aminoacid transporters (GLT1 and GlyT1) and increase of neuronal glutamate transporter EAAC1...
  9. Hwang S, Mahadevan S, Qadir F, Hutchison I, Costea D, Neppelberg E, et al. Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer. 2013;119:4249-58 pubmed publisher
    ..Here, we investigated 8 FOXM1-induced differentially methylated genes, SPCS1, FLNA, CHPF, GLT8D1, C6orf136, MGAT1, NDUFA10, and PAFAH1B3, using human head and neck tissue specimens donated by 2 geographically independent patient ..

More Information

Publications131 found, 100 shown here

  1. Diana M, Santoro M, Xavier G, Santos C, Spindola L, Moretti P, et al. Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR). Psychiatry Res. 2015;229:690-4 pubmed publisher
    ..The aim of this study is to investigate glutamatergic receptors (Gria1 and Grin1) and glycine transporter (Glyt1) gene expression in the prefrontal cortex (PFC) and nucleus accumbens (NAcc) of SHR animals...
  2. Stolfa G, Mondal N, Zhu Y, Yu X, Buffone A, Neelamegham S. Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion. Sci Rep. 2016;6:30392 pubmed publisher
    ..Core 1 β3Gal-T Specific Molecular Chaperone (COSMC), N-glycans by targeting the β1,2 GlcNAc-transferase (MGAT1) and GSLs by deleting UDP-glucose ceramide glucosyltransferase (UGCG)...
  3. Schmidt R, Thompson M. Glycinergic signaling in the human nervous system: An overview of therapeutic drug targets and clinical effects. Ment Health Clin. 2016;6:266-276 pubmed publisher
    ..and are influenced by a multitude of enzymes and transporters, including glycine transporter 1 and 2 (GlyT1 and GlyT2), d-amino acid oxidase (DAAO), serine racemase (SRR), alanine-serine-cysteine transporter 1 (Asc-1), and ..
  4. Taniguchi T, Woodward A, Magnelli P, McColgan N, Lehoux S, Jacobo S, et al. N-Glycosylation affects the stability and barrier function of the MUC16 mucin. J Biol Chem. 2017;292:11079-11090 pubmed publisher
    ..with tunicamycin and siRNA-mediated knockdown of the Golgi N-acetylglucosaminyltransferase I gene (MGAT1) induce partial loss of both total and cell-surface levels of the largest mucin, MUC16, and a concomitant ..
  5. Okuma C, Ohta T, Tadaki H, Hamada H, Oda T, Taniuchi H, et al. JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur J Pharmacol. 2015;758:72-81 pubmed publisher
    ..In addition, JTP-103237 significantly increased MGAT substrate (monoacylglycerol and fatty acid) content in the small intestine...
  6. Gao M, Ma Y, Alsaggar M, Liu D. Dual Outcomes of Rosiglitazone Treatment on Fatty Liver. AAPS J. 2016;18:1023-31 pubmed publisher
    ..with an increased expression of genes responsible for lipid metabolism in the liver, particularly Cd36, Fabp4, and Mgat1. The concurrent transfer of these three genes into the mouse liver fully recapitulates the phenotypic change ..
  7. López Corcuera B, Benito Muñoz C, Aragón C. Glycine Transporters in Glia Cells: Structural Studies. Adv Neurobiol. 2017;16:13-32 pubmed publisher
    ..The unique glial glycine-selective transporter GlyT1 (SLC6) is the main regulator of synaptic glycine concentrations, assisted by the neuronal GlyT2...
  8. Sorbolini S, Gaspa G, Steri R, Dimauro C, Cellesi M, Stella A, et al. Use of canonical discriminant analysis to study signatures of selection in cattle. Genet Sel Evol. 2016;48:58 pubmed publisher
    ..Moreover, new putative candidate genes were identified, such as GCK, B3GALNT1, MGAT1, GALNTL1, PRNP, and PRND. Similar results were obtained with the FST-based approach...
  9. Yan Do R, Duong E, Manning Fox J, Dai X, Suzuki K, Khan S, et al. A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human ?-Cells and Is Impaired in Type 2 Diabetes. Diabetes. 2016;65:2311-21 pubmed publisher
    ..cells express glycine receptors (GlyR), notably the GlyR?1 subunit, and the glycine transporter (GlyT) isoforms GlyT1 and GlyT2...
  10. La Starza R, Barba G, Demeyer S, Pierini V, Di Giacomo D, Gianfelici V, et al. Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia. Haematologica. 2016;101:951-8 pubmed publisher
    ..Down-regulated genes included TRIM41, ZFP62, MAPK9, MGAT1, and CNOT6, all mapping within the 1.4 Mb common deleted region at 5q35.3...
  11. BRANDT C, McFie P, Stone S. Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome. Biochem J. 2016;473:3621-3637 pubmed
    ..We also demonstrated that acyl-CoA:monoacylglycerol acyltransferase (MGAT)-2, an enzyme with extensive sequence homology to DGAT2 that catalyzes the synthesis of diacylglycerol, was also ..
  12. Zimmermann I, Egloff P, Hutter C, Arnold F, Stohler P, Bocquet N, et al. Synthetic single domain antibodies for the conformational trapping of membrane proteins. elife. 2018;7: pubmed publisher
    ..high affinity sybodies against an ABC transporter and two previously intractable human SLC transporters, GlyT1 and ENT1...
  13. Kerscher Hack S, Renukappa Gutke T, Höfner G, Wanner K. Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Eur J Med Chem. 2016;124:852-880 pubmed publisher
    ..The compounds were characterized for inhibitory potencies at mouse GABA transporter proteins mGAT1-mGAT4...
  14. Vogensen S, Jørgensen L, Madsen K, Jurik A, Borkar N, Rosatelli E, et al. Structure activity relationship of selective GABA uptake inhibitors. Bioorg Med Chem. 2015;23:2480-8 pubmed publisher
    ..was synthesized and characterized pharmacologically on mouse ?-amino butyric acid (GABA) transporter subtypes mGAT1-4 in order to investigate structure activity relationships (SAR) for mGAT2 (corresponding to hBGT-1)...
  15. Varnes J, Xiong H, Forst J, Holmquist C, Ernst G, Frietze W, et al. Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett. 2018;28:1043-1049 pubmed publisher
    ..Dimethylbenzamide 9 was tested in a mouse MK801 LMA assay and had a statistically significant attenuation of locomotor activity at 3 and 10??mol/kg compared to control. ..
  16. Tóth K, Höfner G, Wanner K. Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors. Bioorg Med Chem. 2019;27:822-831 pubmed publisher
    ..with a cis double bond applying to the majority of the studied compounds displays a surprisingly high potency at mGAT1 (pIC50 = 6.00 ± 0...
  17. Zeilhofer H, Acuña M, Gingras J, Yevenes G. Glycine receptors and glycine transporters: targets for novel analgesics?. Cell Mol Life Sci. 2018;75:447-465 pubmed publisher
    ..modulators of glycine receptors and modulators or inhibitors of the glial and neuronal glycine transporters GlyT1 and GlyT2...
  18. Tvaroška I. QM/MM methods for studying enzymatic reactions of glycosyltransferases. Methods Mol Biol. 2015;1273:489-99 pubmed publisher
    ..The use of QM/MM methodology is also illustrated using the case of the inverting glycosyltransferase GnT-I. ..
  19. Tóth K, Höfner G, Wanner K. Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors. Bioorg Med Chem. 2018;26:5944-5961 pubmed publisher
    ..The target compounds were characterized with regard to their potency at and subtype selectivity for the GABA transporters mGAT1-mGAT4.
  20. Pinto M, Lima I, da Costa F, Rosa D, Mendes Goulart V, Resende R, et al. Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity. Neuropharmacology. 2015;89:274-81 pubmed publisher
    ..The aim of this work was to evaluate the effects of brain preconditioning induced by NFPS, a GlyT1 inhibitor, against NMDA-induced excitotoxicity in mice hippocampus, as well as to study its neurochemical ..
  21. Hall A, Soufi N, Chambers K, Chen Z, Schweitzer G, McCommis K, et al. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes. 2014;63:2284-96 pubmed publisher
    ..We show that the expression of Mogat1, which encodes MGAT1, and MGAT activity are also increased in diet-induced obese (DIO) and ob/obmice...
  22. Puhl M, Berg A, Bechtholt A, Coyle J. Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse. J Pharmacol Exp Ther. 2015;353:465-70 pubmed publisher
    ..Glycine transporter 1 knockdowns (GlyT1(+/-)) exhibit NMDAR hyperfunction, whereas serine racemase knockouts (SR(-/-)) exhibit NMDAR hypofunction...
  23. Acton D, Miles G. Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks. J Neurophysiol. 2017;117:1877-1893 pubmed publisher
    ..M) failed to alter locomotor-related activity, whereas ALX 5407, a selective inhibitor of glycine transporter-1 (GlyT1), enhanced burst frequency, supporting a role for GlyT1 in NMDAR regulation...
  24. Qanbari S, Gianola D, Hayes B, Schenkel F, Miller S, Moore S, et al. Application of site and haplotype-frequency based approaches for detecting selection signatures in cattle. BMC Genomics. 2011;12:318 pubmed publisher
    ..the regions harboring clustered |iHS| signals revealed a panel of interesting candidate genes like SPATA17, MGAT1, PGRMC2 and ACTC1, COL23A1, MATN2, respectively, in the context of reproduction and muscle formation...
  25. Lutz T, Wein T, Höfner G, Wanner K. Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents. ChemMedChem. 2017;12:362-371 pubmed publisher
    A new scaffold of highly potent and mGAT1-selective inhibitors has been developed. Compounds in this class are characterized by an alkyne-type spacer connecting nipecotic acid with an aromatic moiety...
  26. Ednie A, Deng W, Yip K, Bennett E. Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy. FASEB J. 2019;33:1248-1261 pubmed publisher
    ..The glycosyltransferase gene, mannosyl (α-1,3-)-glycoprotein β-1,2- N-acetylglucosaminyltransferase (Mgat1), whose product, N-acetylglucosaminyltransferase 1 (GlcNAcT1) is necessary for the formation of hybrid and complex ..
  27. Borroni E, Zhou Y, Ostrowitzki S, Alberati D, Kumar A, Hainzl D, et al. Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography. Neuroimage. 2013;75:291-300 pubmed publisher
    A specific positron emission tomography (PET) radiotracer for the glycine transporter type 1 (GlyT1) would constitute an imaging biomarker to investigate the distribution of GlyT1 in normal individuals and those with neuropsychiatric ..
  28. Steffan T, Renukappa Gutke T, Höfner G, Wanner K. Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids. Bioorg Med Chem. 2015;23:1284-306 pubmed publisher
    ..acid derivatives was substituted with alkyl, hydroxy and amino groups to modulate the activity and selectivity to mGAT1 and mGAT4 proteins...
  29. Abdel Rahman A, Ryczko M, Nakano M, Pawling J, Rodrigues T, Johswich A, et al. Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism. Glycobiology. 2015;25:225-40 pubmed publisher
    ..The Golgi branching enzymes N-acetylglucosaminyltransferases I, II, IV, V and avian VI (encoded by Mgat1, Mgat2, Mgat4a/b/c Mgat5 and Mgat6), each catalyze the addition of N-acetylglucosamine (GlcNAc) in N-glycans...
  30. Looi Q, Amin H, Aini I, Zuki M, Omar A. De novo transcriptome analysis shows differential expression of genes in salivary glands of edible bird's nest producing swiftlets. BMC Genomics. 2017;18:504 pubmed publisher
    ..Furthermore, MGAT, an essential gene for the biosynthesis of N-acetylneuraminic acid (sialic acid), was highly expressed in both ..
  31. Banh T, Nelson D, Gao Y, Huang T, Yen M, Yen C. Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intolerance. J Lipid Res. 2015;56:379-89 pubmed publisher
    Acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 catalyzes triacylglycerol (TAG) synthesis, required in intestinal fat absorption...
  32. Chaki S, Shimazaki T, Karasawa J, Aoki T, Kaku A, Iijima M, et al. Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia. Psychopharmacology (Berl). 2015;232:2849-61 pubmed publisher
    ..We investigated the efficacy of a glycine transporter 1 (GlyT1) inhibitor that potentiates NMDA receptor function by increasing synaptic glycine levels in animal models for ..
  33. Soufi N, Hall A, Chen Z, Yoshino J, Collier S, Mathews J, et al. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. J Biol Chem. 2014;289:30177-88 pubmed publisher
    ..Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for ..
  34. Burket J, Benson A, Green T, Rook J, Lindsley C, Conn P, et al. Effects of VU0410120, a novel GlyT1 inhibitor, on measures of sociability, cognition and stereotypic behaviors in a mouse model of autism. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:10-7 pubmed publisher
    ..to promote NMDA receptor-mediated neurotransmission involves inhibition of the glycine type 1 transporter (GlyT1)...
  35. Kurolap A, Armbruster A, Hershkovitz T, Hauf K, Mory A, Paperna T, et al. Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine. Am J Hum Genet. 2016;99:1172-1180 pubmed publisher
    ..Two transporters, GLYT1 and GLYT2, regulate extracellular glycine concentrations within the CNS...
  36. D Souza D, Carson R, Driesen N, Johannesen J, Ranganathan M, Krystal J. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biol Psychiatry. 2018;84:413-421 pubmed publisher
    Glycine transporter-1 (GlyT1) inhibitors may ameliorate cognitive impairments associated with schizophrenia...
  37. Basu A, Puhl M, Coyle J. Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning. Neurobiol Learn Mem. 2016;136:244-250 pubmed publisher
    ..have less than 15% of wild type forebrain levels of D-serine, whereas glycine transporter 1 heterozygous knockout (GlyT1+/-) mice have elevated synaptic glycine...
  38. Liss K, Lutkewitte A, Pietka T, Finck B, Franczyk M, Yoshino J, et al. Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans. J Lipid Res. 2018;: pubmed publisher
    ..We show that expression of the gene that encodes MGAT1 is robustly induced during adipocyte differentiation and that its expression is suppressed in fat of genetically-..
  39. Abd Elhamid T, Elgamal D, Ali S, Ali F, Hassanein E, El Shoura E, et al. Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions. Cell Tissue Res. 2018;374:367-387 pubmed publisher
    ..5% carboxymethyl cellulose and UDCA-pretreated group received UDCA orally for 7 days then co-administered with GNT i.p. for 8 days at the same fore-mentioned doses...
  40. Yan S, Wang H, Schachter H, Jin C, Wilson I, Paschinger K. Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans. Biochim Biophys Acta Gen Subj. 2018;1862:2191-2203 pubmed publisher
    The modification in the Golgi of N-glycans by N-acetylglucosaminyltransferase I (GlcNAc-TI, MGAT1) can be considered to be a hallmark of multicellular eukaryotes as it is found in all metazoans and plants, but rarely in unicellular ..
  41. Barkess G, Postnikov Y, Campos C, Mishra S, Mohan G, Verma S, et al. The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across the Glyt1 gene. Biochem J. 2012;442:495-505 pubmed publisher
    ..In the present study, we have used the Glyt1 (glycine transporter 1) gene as a model system to investigate where HMGN proteins are bound across the locus in ..
  42. Jin Y, McFie P, Banman S, BRANDT C, Stone S. Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis. J Biol Chem. 2014;289:28237-48 pubmed publisher
    ..and an in situ proximity ligation assay, we found that DGAT2 interacted with monoacylglycerol acyltransferase (MGAT)-2, an enzyme that catalyzes the synthesis of diacylglycerol...
  43. Oyama M, Kuraoka S, Watanabe S, Iwai T, Tanabe M. Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice. J Pharmacol Sci. 2017;133:162-167 pubmed publisher
    ..the synaptic and/or extrasynaptic mechanisms underlying pain relief by blockade of glycine transporter subtypes GlyT1 and GlyT2, whole-cell recordings were made from dorsal horn neurons in spinal slices from adult mice, and the ..
  44. Moschetti V, Schlecker C, Wind S, Goetz S, Schmitt H, Schultz A, et al. Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics. Clin Drug Investig. 2018;38:737-750 pubmed publisher
    ..Pharmacokinetic properties support both morning and evening dosing. BI 425809 was generally well tolerated at all tested doses. CLINICALTRIALS. NCT02337283. ..
  45. REED B, Sullivan S, Tsai G, Coyle J, Esguerra M, Miller R. The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina. Eur J Neurosci. 2009;30:2308-17 pubmed publisher
    We examined the role of GlyT1, the high-affinity glycine transporter, in the mouse retina with an emphasis on the role of glycine as a coagonist of N-methyl-D-aspartic acid (NMDA) receptors...
  46. Strzelecki D, Podgórski M, Kałużyńska O, Gawlik Kotelnicka O, Stefańczyk L, Kotlicka Antczak M, et al. Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic (1)NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia. Neurosci Lett. 2015;606:7-12 pubmed publisher
    ..The results confirm involvement of glutamatergic system in the pathogenesis of schizophrenia and demonstrate beneficial effects of GlyT-1 inhibitor on the metabolism in the hippocampus and symptoms of schizophrenia. ..
  47. Adachi R, Ishii T, Ogawa K, Matsumoto S, Satou T, Sakamoto J, et al. Pharmacological characterization of a series of aryl-sulfonamide derivatives that potently and selectively inhibit monoacylglycerol acyltransferase 2. Eur J Pharmacol. 2016;791:569-577 pubmed publisher
    Monoacylglycerol acyltransferase (MGAT) 2 is an endoplasmic reticulum membrane enzyme that catalyzes the synthesis of diacylglycerol (DAG) from fatty acyl-CoA and monoacylglycerol as substrates...
  48. Mihalikova A, Baliova M, Jursky F. Calcium dependent interaction of calmodulin with the GlyT1 C-terminus. Neurochem Res. 2014;39:2225-33 pubmed publisher
    ..We found that several GlyT1 C-terminal mutations, including those in the ER retention signal, either eliminate or increase calmodulin ..
  49. Ghirardini E, Wadle S, Augustin V, Becker J, Brill S, Hammerich J, et al. Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus. Mol Brain. 2018;11:4 pubmed publisher
    ..of these transporters resulted in an inward current (IGly) that was sensitive to the competitive GlyT1 agonist sarcosine. Astrocytes exhibited transcripts for GlyT1 but not for GlyT2...
  50. Yue J, Abraham M, Bauer P, Lapierre M, Wang P, Duca F, et al. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat Commun. 2016;7:13501 pubmed publisher
    ..Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, ..
  51. Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S. Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase. Biochem Biophys Res Commun. 2018;502:98-103 pubmed publisher
    ..Our data suggests that thorough glycosylation of NCT is critical for enzymatic activity and substrate preference of γ-secretase. ..
  52. Wolkenberg S, Sur C. Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors. Curr Top Med Chem. 2010;10:170-86 pubmed
    ..A key component of cerebral glycine metabolism is the glycine transporter type 1 (GlyT1) and elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to ..
  53. Pinard E, Borroni E, Koerner A, Umbricht D, Alberati D. Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient. Chimia (Aarau). 2018;72:477-484 pubmed publisher
    Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new approach to treat schizophrenia, a severe and chronic mental illness...
  54. Komatsu H, Furuya Y, Sawada K, Asada T. Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups. Eur J Pharmacol. 2015;746:252-7 pubmed publisher
    Several studies have shown that glycine transporter 1 (GlyT1) inhibitors have anxiolytic actions...
  55. Romei C, Raiteri L. Advances in understanding the functions of native GlyT1 and GlyT2 neuronal glycine transporters. Neurochem Int. 2016;99:169-177 pubmed publisher
    Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings...
  56. Kural K, Tandon N, Skoblov M, Kel Margoulis O, Baranova A. Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. BMC Genomics. 2016;17:1030 pubmed publisher
    ..Moreover, stromelysin/MMP3 and N-acetylglucosaminyltransferase enzyme MGAT1, which initiates the synthesis of hybrid and complex Nglycans, were identified as key orchestrating components in ..
  57. Eulenburg V, Knop G, Sedmak T, Schuster S, Hauf K, Schneider J, et al. GlyT1 determines the glycinergic phenotype of amacrine cells in the mouse retina. Brain Struct Funct. 2018;223:3251-3266 pubmed publisher
    ..and binding to postsynaptic receptors at caudal glycinergic synapses, two high-affinity glycine transporters GlyT1 and GlyT2 remove glycine from the extracellular space...
  58. Soulages J, Wu Z, Firdaus S, Mahalingam R, Arrese E. Monoacylglycerol and diacylglycerol acyltransferases and the synthesis of neutral glycerides in Manduca sexta. Insect Biochem Mol Biol. 2015;62:194-210 pubmed publisher
    ..Monoacylglycerol acyltransferase (MGAT), which catalyzes the synthesis of DG from MG, and a diacylglycerol acyltransferase (DGAT), which catalyzes the ..
  59. Kern F, Wanner K. Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1. ChemMedChem. 2015;10:396-410 pubmed publisher
    ..far applied to pseudostatic hydrazine libraries, to static oxime libraries to screen for new potent inhibitors of mGAT1, the most abundant GABA transporter in the central nervous system that represents a validated drug target for the ..
  60. Richard S, Baltz J. Preovulatory suppression of mouse oocyte cell volume-regulatory mechanisms is via signalling that is distinct from meiotic arrest. Sci Rep. 2017;7:702 pubmed publisher
    b>GLYT1-mediated glycine transport is the main cell volume-homeostatic mechanism in mouse eggs and early preimplantation embryos. It is unique to these developmental stages and key to their healthy development...
  61. Wong D, Ostrowitzki S, Zhou Y, Raymont V, Hofmann C, Borroni E, et al. Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans. Neuroimage. 2013;75:282-290 pubmed publisher
    We characterize a novel radioligand for the glycine transporter type 1 (GlyT1), [(11)C]RO5013853, in humans...
  62. Sałat K, Kulig K, Sałat R, Filipek B, Malawska B. Analgesic and anticonvulsant activity of new derivatives of 2-substituted 4-hydroxybutanamides in mice. Pharmacol Rep. 2012;64:102-12 pubmed
    ..GT28, GT29 and BM128 revealed their inhibitory action towards murine γ-aminobutyric acid (GABA) transporters (mGAT1-mGAT4)...
  63. Chue P. Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr Pharm Des. 2013;19:1311-20 pubmed
    ..for enhancing NMDAR function involves modification of the activity of the high affinity glycine transporter 1 (GlyT1)...
  64. Akiva I, Birgül Iyison N. MGAT1 is a novel transcriptional target of Wnt/?-catenin signaling pathway. BMC Cancer. 2018;18:60 pubmed publisher
    ..We previously showed that Mannosyl glycoprotein acetylglucosaminyl-transferase (MGAT1) enzyme is among the Wnt/?-catenin signaling putative target genes in hepatocellular carcinoma cell lines (Huh7)...
  65. Jiménez E, Núñez E, Ibáñez I, Zafra F, Aragón C, Giménez C. Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β. Neuropharmacology. 2015;89:245-54 pubmed publisher
    Inhibitory glycinergic neurotransmission is terminated by the specific glycine transporters GlyT1 and GlyT2 which actively reuptake glycine from the synaptic cleft...
  66. Singer P, Dubroqua S, Yee B. Inhibition of glycine transporter 1: The yellow brick road to new schizophrenia therapy?. Curr Pharm Des. 2015;21:3771-87 pubmed
    ..possibly fill this urgent medical need have been prompted by the recent development of glycine transporter 1 (GlyT1) inhibitors...
  67. Voisin S, Almén M, Zheleznyakova G, Lundberg L, Zarei S, Castillo S, et al. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers. Genome Med. 2015;7:103 pubmed publisher
    ..38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ..
  68. Asselot R, Simon O Brien E, Lebourgeois S, Nee G, Delaunay V, Duchatelle P, et al. Time-dependent impact of glutamatergic modulators on the promnesiant effect of 5-HT6R blockade on mice recognition memory. Pharmacol Res. 2017;118:111-118 pubmed publisher
    ..blocked by the competitive antagonist at NMDAR, CGS 19755, or potentiated by the glycine transporter type 1 (GlyT1) inhibitor, NFPS...
  69. Lee Y, Kim J. Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis. BMB Rep. 2017;50:367-372 pubmed
    ..In this report, we identified that murine MGAT1 localizes to the endoplasmic reticulum (ER) under normal conditions, whereas MGAT1 co-localize to the lipid ..
  70. Ma Z, Onorato J, Chen L, Nelson D, Yen C, Cheng D. Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. J Lipid Res. 2017;58:1091-1099 pubmed publisher
    ..examined, acyl-CoA:diacylglycerol acyltransferase (DGAT)1, DGAT2, acyl-CoA:monoacylglycerol acyltransferase (MGAT)2, MGAT3, acyl-CoA:wax-alcohol acyltransferase 2/MFAT, and DGAT candidate 3 were able to use 1-monoalkylglycerol (1-..
  71. Costa W, Amorim P, Mattos J. Molecular phylogeny and evolution of internal fertilization in South American seasonal cynopoeciline killifishes. Mol Phylogenet Evol. 2016;95:94-9 pubmed publisher
    ..We analyzed three nuclear loci (GLYT1, ENC1, Rho) for 13 aplocheiloid taxa obtaining the first well-supported phylogeny for cynopoecilines, thus ..
  72. Winter M, Funk J, Körner A, Alberati D, Christen F, Schmitt G, et al. Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats. Exp Hematol. 2016;44:964-974.e4 pubmed publisher
    ..cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1)...
  73. Yang Q, An Y, Zhu S, Zhang R, Loke C, Cipollo J, et al. Glycan Remodeling of Human Erythropoietin (EPO) Through Combined Mammalian Cell Engineering and Chemoenzymatic Transglycosylation. ACS Chem Biol. 2017;12:1665-1673 pubmed publisher
    ..We found that the generation of a HEK293S GnT I knockout FUT8 overexpressing cell line enabled the production of an unusual Man5GlcNAc2Fuc ..
  74. Garcia Santos D, Schranzhofer M, Bergeron R, Sheftel A, Ponka P. Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells. Haematologica. 2017;102:1314-1323 pubmed publisher
    ..To address this issue, we exploited mice in which the gene encoding glycine transporter 1 (GlyT1) was disrupted...
  75. Biswas B, Batista F, Sundaram S, Stanley P. MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis. Sci Rep. 2018;8:2022 pubmed publisher
    ..We previously showed that conditional deletion of the mouse Mgat1 gene (Mgat1 cKO) in spermatogonia causes a germ-cell autonomous defect leading to infertility...
  76. Shen H, van Vliet E, Bright K, Hanthorn M, Lytle N, Gorter J, et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015;99:554-65 pubmed publisher
    ..In hippocampus, the synaptic availability of glycine is largely under control of glycine transporter 1 (GlyT1)...
  77. Petrera M, Wein T, Allmendinger L, Sindelar M, Pabel J, Höfner G, et al. Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions. ChemMedChem. 2016;11:519-38 pubmed publisher
    A new series of potent and selective mGAT1 inhibitors has been identified, featuring a nipecotic acid residue and an N-butenyl linker with a 2-biphenyl residue at the ω-position...
  78. McFie P, Izzard S, Vu H, Jin Y, Beauchamp E, Berthiaume L, et al. Membrane topology of human monoacylglycerol acyltransferase-2 and identification of regions important for its localization to the endoplasmic reticulum. Biochim Biophys Acta. 2016;1861:1192-1204 pubmed publisher
    Acyl CoA:2-monoacylglycerol acyltransferase (MGAT)-2 has an important role in dietary fat absorption in the intestine...
  79. Li K, Olsen R. Metabolism of sn-1(3)-Monoacylglycerol and sn-2-Monoacylglycerol in Caecal Enterocytes and Hepatocytes of Brown Trout (Salmo trutta). Lipids. 2017;52:61-71 pubmed publisher
    ..The 2-MAG was quickly resynthesized into TAG through the monoacylglycerol acyltransferase (EC: 2.3.1.22, MGAT) pathway in both tissues, whereas 1(3)-MAG was processed into TAG and phospholipids at a much slower rate, ..
  80. Cha H, Lim J, Yeon J, Hwang J, Kim D. Co-overexpression of Mgat1 and Mgat4 in CHO cells for production of highly sialylated albumin-erythropoietin. Enzyme Microb Technol. 2017;103:53-58 pubmed publisher
    ..N-acetylglucosaminyltransferases I, II, IV, and V (i.e. Mgat1, Mgat2, Mgat4, and Mgat5) catalyze the formation of a glycan antennary structure...
  81. Vengeliene V, Roßmanith M, Takahashi T, Alberati D, Behl B, Bespalov A, et al. Targeting Glycine Reuptake in Alcohol Seeking and Relapse. J Pharmacol Exp Ther. 2018;365:202-211 pubmed publisher
    It has recently been demonstrated that pharmacological blockade of the glycine transporter 1 (GlyT1) reduced alcohol intake and relapse in rats...
  82. Jursky F, Baliova M, Juhasova A. Structural insights into the benzophenanthridines binding to human glycine transporter GlyT1. Eur J Pharmacol. 2015;765:1-6 pubmed publisher
    ..To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated several amino acids in the vicinity of cysteine 475...
  83. Agarwal A, Tunison K, Dalal J, Yen C, Farese R, Horton J, et al. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016;57:616-30 pubmed publisher
    ..MOGAT1 possesses MGAT activity in in vitro assays, but its physiological function in TAG metabolism is unknown...
  84. Dunayevich E, Buchanan R, Chen C, Yang J, Nilsen J, Dietrich J, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017;182:90-97 pubmed publisher
    To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms...
  85. Jafri A, Arfuzir N, Lambuk L, Iezhitsa I, Agarwal R, Agarwal P, et al. Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis. J Trace Elem Med Biol. 2017;39:147-154 pubmed publisher
    ..Therefore, the aim of this study was to evaluate the effect of Mg acetyltaurate (MgAT) on the retinal mineral and trace element concentration, oxidative stress, retinal morphology and retinal cell ..
  86. Aroeira R, Sebastião A, Valente C. BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes. Glia. 2015;63:2181-97 pubmed publisher
    Glycine transporters (GlyT), GlyT1 and GlyT2, are responsible for the termination of glycine-mediated synaptic activity through removal of neurotransmitter from synaptic cleft...
  87. Zang L, Wang Y, Sun B, Zhang X, Yang C, Kang L, et al. Identification of a 13 bp indel polymorphism in the 3'-UTR of DGAT2 gene associated with backfat thickness and lean percentage in pigs. Gene. 2016;576:729-33 pubmed publisher
    ..3.1.20) is a member of acyl-CoA: monoacylglycerol acyltransferase (MGAT) family, which catalyzes one fatty acyl-CoA and diacylglycerol (DG) molecule to form triacylglycerols (TG) and is ..
  88. Yang Q, Wang L. Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans. J Biol Chem. 2016;291:11064-71 pubmed publisher
    ..We found that expression of erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)(-/-) cell line resulted in production of the Man5GlcNAc2 glycoforms, in which more than 50% were core-fucosylated,..
  89. Lambuk L, Jafri A, Arfuzir N, Iezhitsa I, Agarwal R, Rozali K, et al. Neuroprotective Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity in Rat Retina. Neurotox Res. 2017;31:31-45 pubmed publisher
    ..The purpose of the present study was to examine the potential neuroprotective effect of Mg acetyltaurate (MgAT) on RGC death induced by NMDA...
  90. Schlösser L, Barthel F, Brandenburger T, Neumann E, Bauer I, Eulenburg V, et al. Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion--Possible implications for neuropathic pain. Neurosci Lett. 2015;600:213-9 pubmed publisher
    ..The glycine concentration in the synaptic cleft is controlled by the glycine transporters GlyT1 and GlyT2...
  91. Casey C, Bhat G, Holzapfel M, Petrosyan A. Study of Ethanol-Induced Golgi Disorganization Reveals the Potential Mechanism of Alcohol-Impaired N-Glycosylation. Alcohol Clin Exp Res. 2016;40:2573-2590 pubmed publisher
    ..Characterization of Golgi-associated mannosyl (?-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1), ?-1,2-mannosidase (Man-I), and ?-mannosidase II (Man-II) were performed in VA-13 cells and rat hepatocytes ..
  92. Okuma C, Ohta T, Tadaki H, Ishigure T, Sakata S, Taniuchi H, et al. JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J Pharmacol Sci. 2015;128:150-7 pubmed publisher
    ..In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and hepatic lipid metabolism...