Gene Symbol: MFNG
Description: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Alias: beta-1,3-N-acetylglucosaminyltransferase manic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Species: human
Products:     MFNG

Top Publications

  1. Moran J, Johnston S, Rauskolb C, Bhalerao J, Bowcock A, Vogt T. Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. Mamm Genome. 1999;10:535-41 pubmed
    The three members of the mammalian fringe gene family, Manic fringe (Mfng), Radical fringe (Rfng), and Lunatic fringe (Lfng), were identified on the basis of their similarity to Drosophila fringe (fng) and their participation in the ..
  2. Otomo N, Mizumoto S, Lu H, Takeda K, Campos Xavier B, Mittaz Crettol L, et al. Identification of novel LFNG mutations in spondylocostal dysostosis. J Hum Genet. 2019;64:261-264 pubmed publisher
    ..The missense variant was in the DxD motif, an active-site motif of the glycosyltransferase, and its loss of the enzyme function was confirmed by an in vitro enzyme assay. This is the second report of LFNG mutations in SCDO. ..
  3. López Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng J, et al. Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. Nat Commun. 2018;9:2992 pubmed publisher
    ..Addiction to Jag1 is concomitant with the absence of Manic Fringe (MFNG) in adenoma cells, and its ectopic expression reverts Jag1 dependence...
  4. Wang H, Jiang Z, Zhang J, Xie Z, Wang Y, Yang G. Enhanced osteogenic differentiation of rat bone marrow mesenchymal stem cells on titanium substrates by inhibiting Notch3. Arch Oral Biol. 2017;80:34-40 pubmed publisher
    ..included up-regulated genes (Notch2, Dll1, Dll3, Ncstn, Ncor2, and Hes5) and down-regulated genes (Notch3, Lfng, Mfng, Jag2 and Maml2)...
  5. D Amato G, Luxán G, del Monte Nieto G, Martínez Poveda B, Torroja C, Walter W, et al. Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol. 2016;18:7-20 pubmed publisher
    ..chamber, through a temporal sequence of ligand signalling determined by the glycosyltransferase manic fringe (MFng)...
  6. Adhikary P, Mandal D. Enhanced electro-active phase in a luminescent P(VDF-HFP)/Zn2+ flexible composite film for piezoelectric based energy harvesting applications and self-powered UV light detection. Phys Chem Chem Phys. 2017;19:17789-17798 pubmed publisher
    ..P(VDF-HFP)) and Zn2+ for the fabrication of a multifunctional piezoelectric based nanogenerator (MFNG), where a traditional electrical poling treatment was avoided...
  7. Basch M, Brown R, Jen H, Semerci F, Depreux F, Edlund R, et al. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. elife. 2016;5: pubmed publisher
    ..We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti...
  8. Frederick M, Berhanu A, Bartlett R. Chest Surgery in Female to Male Transgender Individuals. Ann Plast Surg. 2017;78:249-253 pubmed publisher
    ..with or without a periareolar mastopexy or nipple reduction, or bilateral mastectomies with free nipple grafts (MFNG) with or without nipple reduction. Surgical techniques are discussed...
  9. Song Y, Kumar V, Wei H, Qiu J, Stanley P. Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development. J Immunol. 2016;196:232-43 pubmed publisher
    Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling...

More Information


  1. Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher W, Leow C, et al. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet. 1997;16:283-8 pubmed
    ..Ectopic expression of murine manic fringe or radical fringe in Drosophila results in phenotypes that resemble those seen in Notch mutants. ..
  2. Moloney D, Panin V, Johnston S, Chen J, Shao L, Wilson R, et al. Fringe is a glycosyltransferase that modifies Notch. Nature. 2000;406:369-75 pubmed
  3. Johnston S, Rauskolb C, Wilson R, Prabhakaran B, Irvine K, Vogt T. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997;124:2245-54 pubmed
    ..When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination. ..
  4. Veeraraghavalu K, Pett M, Kumar R, Nair P, Rangarajan A, Stanley M, et al. Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol. 2004;78:8687-700 pubmed
    ..Suppressor of Hairless, Lag1)-driven reporter activity and a decrease in Manic Fringe upstream regulatory region (MFng-URR)-driven reporter activity was observed in late-passage versus early passage W12...
  5. Zhang S, Chung W, Wu G, Egan S, Miele L, Xu K. Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Res. 2015;75:1936-43 pubmed publisher
    ..Here, we report that Manic Fringe (Mfng), which encodes an O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase known to modify EGF repeats in the Notch ..
  6. Panin V, Shao L, Lei L, Moloney D, Irvine K, Haltiwanger R. Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem. 2002;277:29945-52 pubmed
    ..A revised, broad consensus site, C(2)X(3-5)S/TC(3) (where X(3-5) are any 3-5 amino acid residues), is proposed. ..
  7. Thélu J, Rossio P, Favier B. Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. BMC Dermatol. 2002;2:7 pubmed
    ..The Notch signalling involved in the differentiation programme of normal adult human epidermis is altered under experimental conditions and pathologies which modify this programme. ..
  8. Egan S, Herbrick J, Tsui L, Cohen B, Flock G, Beatty B, et al. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. Genomics. 1998;54:576-7 pubmed
  9. Shao L, Moloney D, Haltiwanger R. Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. J Biol Chem. 2003;278:7775-82 pubmed
    ..These findings provide insight into potential mechanisms by which Fringe action on Notch receptors may influence both the affinity of Notch-ligand binding and cell-autonomous inhibition of Notch signaling by ligand. ..
  10. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem. 2001;276:25753-8 pubmed
    ..Although both manic fringe (mFng) and lunatic fringe (lFng) decreased the binding of Jagged1 to Notch2 and not that of Delta1, the decrease by mFng ..
  11. Van Tine B, Knops J, Shaw G, May W. Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH). Cytogenet Cell Genet. 1999;87:132-3 pubmed