Gene Symbol: METTL16
Description: methyltransferase like 16
Alias: METT10D, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, N6-adenosine-methyltransferase METTL16, U6 snRNA methyltransferase, methyltransferase 10 domain containing, methyltransferase 10 domain-containing protein, methyltransferase-like protein 16
Species: human
Products:     METTL16

Top Publications

  1. Sudo K, Chinen K, Nakamura Y. 2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library. Genomics. 1994;24:276-9 pubmed
    ..6% showed no homology to any genes or DNA sequences in the public database. These data and reagents will be useful for future investigations of gene expression during prenatal development of human lung. ..
  2. Warda A, Kretschmer J, Hackert P, Lenz C, Urlaub H, Hobartner C, et al. Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017;18:2004-2014 pubmed publisher
    ..Using crosslinking and analysis of cDNA (CRAC), we reveal that the putative human m6A "writer" protein METTL16 binds to the U6 snRNA and other ncRNAs as well as numerous lncRNAs and pre-mRNAs...
  3. Sergiev P, Serebryakova M, Bogdanov A, Dontsova O. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. J Mol Biol. 2008;375:291-300 pubmed
    ..It might be suggested that A1618 modification could be necessary for the exit tunnel interaction with some unknown regulatory peptides...
  4. Docherty S, Kovas Y, Petrill S, Plomin R. Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. BMC Genet. 2010;11:61 pubmed publisher
    ..With small effect sizes expected in such complex traits, future studies may be able to capitalise on power by searching for 'generalist genes' using longitudinal and multivariate approaches. ..
  5. Brown J, Kinzig C, DeGregorio S, Steitz J. Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA. Proc Natl Acad Sci U S A. 2016;113:14013-14018 pubmed
    ..lysate using a biotinylated-RNA probe followed by mass spectrometry identified methyltransferase-like protein 16 (METTL16), a putative RNA methyltransferase, as an interacting protein of the MALAT1 ENE+A...
  6. Pendleton K, Chen B, Liu K, Hunter O, Xie Y, Tu B, et al. The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017;169:824-835.e14 pubmed publisher
    ..These observations suggest that the conserved U6 snRNA methyltransferase evolved an additional function in vertebrates to regulate SAM homeostasis.