metaxin 2


Gene Symbol: metaxin 2
Description: metaxin 2
Alias: metaxin-2, mitochondrial outer membrane import complex protein 2
Species: human
Products:     metaxin 2

Top Publications

  1. Li Q, So C, Fegan A, Cody V, Sarikaya M, Vallera D, et al. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic. J Am Chem Soc. 2010;132:17247-57 pubmed publisher
    ..Further the CSAN construct may be adapted for the preparation of other multivalent scFvs. ..
  2. Cha S, Lim J, Park A, Do J, Lee S, Shin C, et al. Identification of five novel genetic loci related to facial morphology by genome-wide association studies. BMC Genomics. 2018;19:481 pubmed publisher
    ..We identified five novel face morphology loci that were associated with facial frontal contour, nose shape, and eye shape. Our findings provide useful genetic information for the determination of face morphology. ..
  3. Palma L, Muñoz D, Berry C, Murillo J, Caballero P. Bacillus thuringiensis toxins: an overview of their biocidal activity. Toxins (Basel). 2014;6:3296-325 pubmed publisher
    ..In this review, we provide an updated overview of the known active Bt toxins to date and discuss their activities. ..
  4. Huynen M, Mühlmeister M, Gotthardt K, Guerrero Castillo S, Brandt U. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Biochim Biophys Acta. 2016;1863:91-101 pubmed publisher
  5. He X, Zhou Z, Pu Y, Chen X, Ma Y, Jiang L. Mapping the four-horned locus and testing the polled locus in three Chinese sheep breeds. Anim Genet. 2016;47:623-7 pubmed publisher
    ..The two identified SNPs were both downstream of the metaxin 2 (MTX2) gene and the HOXD gene cluster. For the top SNP-OAR2:g...
  6. Kozjak Pavlovic V, Ross K, Benlasfer N, Kimmig S, Karlas A, Rudel T. Conserved roles of Sam50 and metaxins in VDAC biogenesis. EMBO Rep. 2007;8:576-82 pubmed
    ..b>Metaxin 2-depleted mitochondria had reduced levels of metaxin 1 and were deficient in import and assembly of VDAC and ..
  7. Xie J, Marusich M, Souda P, Whitelegge J, Capaldi R. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett. 2007;581:3545-9 pubmed
  8. Guarani V, McNeill E, Paulo J, Huttlin E, Fröhlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
    ..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..
  9. Petit E, Cartron P, Oliver L, Vallette F. The phosphorylation of Metaxin 1 controls Bak activation during TNF? induced cell death. Cell Signal. 2017;30:171-178 pubmed publisher
    ..shown that Bak is incorporated into a Voltage dependent anionic channel of type 2 (VDAC2)/Metaxin 1(Mtx1)/Metaxin 2 (Mtx2) multi-protein complex in both resting and dying cells...

More Information


  1. Liu Y, Wang Y, Shu C, Lin K, Song F, Bravo A, et al. Cry64Ba and Cry64Ca, Two ETX/MTX2-Type Bacillus thuringiensis Insecticidal Proteins Active against Hemipteran Pests. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Cry64Ba and Cry64Ca showed no toxicity against some lepidopteran or coleopteran pests. These two proteins should be able to be used for integrated hemipteran pest management. ..
  2. Armstrong L, Saenz A, Bornstein P. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. J Cell Biochem. 1999;74:11-22 pubmed
    ..A yeast two-hybrid screen with metaxin 1 as bait has now identified a novel protein, which we have termed metaxin 2, as a metaxin 1-binding protein...
  3. Pisapia F, Sibat M, Herrenknecht C, Lhaute K, Gaiani G, Ferron P, et al. Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus. Mar Drugs. 2017;15: pubmed publisher
    ..MTX4 may therefore serve as a biomarker for the highly toxic G. excentricus in the Atlantic area. ..