MESP2

Summary

Gene Symbol: MESP2
Description: mesoderm posterior 2 homolog (mouse)
Alias: SCDO2, bHLHc6, class C basic helix-loop-helix protein 6, mesoderm posterior protein 2
Species: human

Top Publications

  1. doi Oscillatory links of Fgf signaling and Hes7 in the segmentation clock
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Curr Opin Genet Dev 23:484-90. 2013
  2. ncbi Transgenic analysis of the medaka mesp-b enhancer in somitogenesis
    Harumi Terasaki
    Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Growth Differ 48:153-68. 2006
  3. doi Tetrasomy 15q25.2→qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation
    Jaya K George-Abraham
    Division of Human Genetics, Department of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Med Genet A 158:1971-6. 2012
  4. doi Brothers with hypospadias, vertebral segmentation defects, and intellectual disability: new syndrome?
    Shubha R Phadke
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Med Genet A 158:3065-70. 2012
  5. doi Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis
    Yuji Makino
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Bone 53:248-58. 2013
  6. doi Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Hum Mol Genet 22:1625-31. 2013
  7. doi Embryonic fibroblasts represent a connecting link between mesenchymal and embryonic stem cells
    Batul Yusuf
    Manipal Institute of Regenerative Medicine, Manipal University Branch Campus, Yelahanka, Bangalore, 560 065, Karnataka, India
    Dev Growth Differ 55:330-40. 2013
  8. ncbi Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
    Xu Sheng Qiu
    Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Stud Health Technol Inform 176:52-5. 2012
  9. pmc EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation
    Tadayoshi Watanabe
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 106:7467-72. 2009
  10. doi Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2
    Yukuto Yasuhiko
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Development 135:3511-9. 2008

Scientific Experts

  • Y Saga
  • Shubha R Phadke
  • R Kageyama
  • Kenro Kusumi
  • B Christ
  • Zoran Gucev
  • Yukuto Yasuhiko
  • Sally L Dunwoodie
  • Peter D Turnpenny
  • D J Amor
  • Andrew S McLellan
  • Yu Takahashi
  • Duncan B Sparrow
  • Masayuki Oginuma
  • Mitsuru Morimoto
  • Jun Kanno
  • Nobuo Sasaki
  • Makoto Kiso
  • Keisuke Hitachi
  • Satoshi Kitajima
  • Alberto S Cornier
  • Yuji Makino
  • Batul Yusuf
  • Yukiko Harima
  • Jaya K George-Abraham
  • Xu Sheng Qiu
  • Gloria H Y Li
  • Chunwang Dang
  • Walter E Berdon
  • Deborah L Chapman
  • S Kitajima
  • Tohru Inoue
  • Charalampos Rallis
  • Jun Takahashi
  • Daisuke Saito
  • Norman Ramirez
  • Tadayoshi Watanabe
  • Hiroki Danno
  • Makoto Asashima
  • Akiko Kondow
  • Henner F Farin
  • William C Dunty
  • David Coman
  • Olivier Pourquie
  • Albert Goldbeter
  • Yu Liu
  • David Sillence
  • Merridee A Wouters
  • Haruhiko Koseki
  • Harumi Terasaki
  • Shuichi Hiraoka
  • Yoshiro Nakajima
  • K Koizumi
  • Andreas Kispert
  • Jihua Chen
  • D B Sparrow
  • Sian Ellard
  • Marianne Petry
  • T Inoue
  • A Takagi
  • Alan Rawls
  • Markus Bussen
  • Hiroyuki Takeda
  • Neil V Whittock
  • Achim Gossler
  • Jerry Rhee
  • Aya Nomura-Kitabayashi
  • Tadahiro Iimura
  • Paul J Leo
  • Renjitha Gopurappilly
  • Miwako Hamagaki
  • Matthew A Brown
  • Kazuo Kaneko
  • Nidheesh Dadheech
  • Takashi Watanabe
  • Toshiyuki Yoneda
  • Abduhadi Shishko
  • Yoshihiro Tamamura
  • Rieko Tanabe
  • Brooke Gardiner
  • Ramesh Bhonde
  • Rajarshi Pal
  • Akira Yamaguchi
  • Mhairi Marshall
  • Mayu Haraikawa
  • Emma L Duncan
  • Aideen McInerney-Leo
  • Masae Goseki-Sone
  • Velibor Tasic
  • Sarita Gupta

Detail Information

Publications66

  1. doi Oscillatory links of Fgf signaling and Hes7 in the segmentation clock
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Curr Opin Genet Dev 23:484-90. 2013
    ..clock, where the oscillatory expression of cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for somite formation...
  2. ncbi Transgenic analysis of the medaka mesp-b enhancer in somitogenesis
    Harumi Terasaki
    Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Growth Differ 48:153-68. 2006
    ..By interacting with these pathways, the Mesp2-like bHLH transcription factors are transiently expressed in the anterior presomitic mesoderm and play a crucial ..
  3. doi Tetrasomy 15q25.2→qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation
    Jaya K George-Abraham
    Division of Human Genetics, Department of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Med Genet A 158:1971-6. 2012
    ..We propose overexpression of three genes, ADAMTSL3, MESP1, and MESP2 as a potential mechanism for cardiac and vessel malformations associated with tetrasomy 15q...
  4. doi Brothers with hypospadias, vertebral segmentation defects, and intellectual disability: new syndrome?
    Shubha R Phadke
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Med Genet A 158:3065-70. 2012
    ..copy number variants, microarray-CGH analysis, and sequencing of four Notch signaling pathway genes (DLL3, MESP2, LFNG, and HES7), were all normal...
  5. doi Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis
    Yuji Makino
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Bone 53:248-58. 2013
    Spondylocostal dysostosis (SCDO) is a genetic disorder characterized by severe malformation of the axial skeleton. Mesp2 encodes a basic helix-loop-helix type transcription factor that is required for somite formation...
  6. doi Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Hum Mol Genet 22:1625-31. 2013
    ..forms of autosomal recessive SCD cases has been solved with the identification of four causative genes (DLL3, MESP2, LFNG and HES7)...
  7. doi Embryonic fibroblasts represent a connecting link between mesenchymal and embryonic stem cells
    Batul Yusuf
    Manipal Institute of Regenerative Medicine, Manipal University Branch Campus, Yelahanka, Bangalore, 560 065, Karnataka, India
    Dev Growth Differ 55:330-40. 2013
    ..SSEA-1, Oct-4, Nanog, Sox-2 and ABCG2 as pluripotency markers; Nestin, β-III tubulin, Otx-2 (ectoderm); MEF-2, Mesp2, GATA-2 (mesoderm) and GATA-4, α-amylase, PDX-1 (endoderm) as tri-lineage markers...
  8. ncbi Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
    Xu Sheng Qiu
    Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Stud Health Technol Inform 176:52-5. 2012
    b>MESP2, HES7 and DUSP6 genes have been proved to be involved in the etiopathogenesis of congenital scoliosis (CS) in animal embryo studies, however, whether this association was detected in human CS patients also remains unknown...
  9. pmc EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation
    Tadayoshi Watanabe
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 106:7467-72. 2009
    ..We here demonstrate that cMeso-1, the chicken homolog of mouse Mesp2, up-regulates EphA4 in the cells located posteriorly to a forming boundary...
  10. doi Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2
    Yukuto Yasuhiko
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Development 135:3511-9. 2008
    The T-box transcription factor Tbx6 controls the expression of Mesp2, which encodes a basic helix-loop-helix transcription factor that has crucial roles in somitogenesis...
  11. doi Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor ChangCardiac Research Institute, Darlinghurst, Sydney, NSW, Australia
    Hum Mol Genet 17:3761-6. 2008
    ..a subset of autosomal recessive forms of this disease have been identified: DLL3 (SCDO1: MIM 277300), MESP2 (SCDO2: MIM 608681) and LFNG (SCDO3: MIM609813)...
  12. doi T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm
    Henner F Farin
    Institute for Molecular Biology, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Strasse 1, Hannover, Germany
    J Biol Chem 283:25372-80. 2008
    ..Anterior-posterior somite polarity is generated in the anterior presomitic mesoderm by Mesp2 and Delta/Notch signaling and is further maintained by two transcriptional regulators, Uncx4...
  13. doi Spondylocostal dysostosis in a pregnancy complicated by confined placental mosaicism for tetrasomy 9p
    David Coman
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Am J Med Genet A 146:1972-6. 2008
    ..Testing of the genes DLL3, MESP2, and LFNG did not identify a mutation, suggesting that the siblings may have a new molecular subtype of SCD.
  14. doi Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka, Japan
    Development 135:2555-62. 2008
    ..The transcription factor Mesp2 plays a crucial role in this process, regulating segmental border formation and rostro-caudal patterning...
  15. doi Physical interaction between Tbx6 and mespb is indispensable for the activation of bowline expression during Xenopus somitogenesis
    Keisuke Hitachi
    Department of Life Sciences Biology, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
    Biochem Biophys Res Commun 372:607-12. 2008
    ..signaling crosstalk that occurs between two major transcription factors involved in somitogenesis, Tbx6 and mespb/mesp2. These factors synergistically activated the expression of a downstream gene, bowline/Ripply2, which is essential ..
  16. pmc Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
    Alberto S Cornier
    Department of Molecular Medicine, La Concepcion Hospital, San German, PR 00683, USA
    Am J Hum Genet 82:1334-41. 2008
    ..in mouse segmentation, we identified a recessive E103X nonsense mutation in the mesoderm posterior 2 homolog (MESP2) gene in a patient, of Puerto Rican origin and from the Boston area, who had been diagnosed with STD/JLS...
  17. doi Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Mech Dev 125:432-40. 2008
    ..Using this method, we have analyzed the Mesp1 and/or Mesp2 enhancers and identified P1-PSME, a PSM-specific enhancer of Mesp1, which contains a T-box binding site similar to ..
  18. ncbi Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
    William C Dunty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
    Development 135:85-94. 2008
    ..The Wnt3a/beta-catenin pathway does so by regulating the activation of the segment boundary determination genes Mesp2 and Ripply2 in the PSM through the activation of the Notch ligand Dll1 and the mesodermal transcription factors T ..
  19. doi The role of Notch in patterning the human vertebral column
    Sally L Dunwoodie
    Developmental Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010 Sydney, Australia
    Curr Opin Genet Dev 19:329-37. 2009
    ..More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans...
  20. pmc Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Eur J Hum Genet 18:674-9. 2010
    ..a subset of autosomal recessive forms of this disease have been identified: DLL3 (SCDO1: MIM 277300), MESP2 (SCDO2: MIM 608681), LFNG (SCDO3: MIM609813) and HES7 (SCDO4)...
  21. pmc A genome-wide survey on basic helix-loop-helix transcription factors in giant panda
    Chunwang Dang
    Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, People s Republic of China
    PLoS ONE 6:e26878. 2011
    ..Compared to mouse, the giant panda does not encode seven bHLH proteins namely Beta3a, Mesp2, Sclerax, S-Myc, Hes5 (or Hes6), EBF4 and Orphan 1...
  22. doi Identification of genes for bone mineral density variation by computational disease gene identification strategy
    Gloria H Y Li
    Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China
    J Bone Miner Metab 29:709-16. 2011
    ..factor binding suggested that the minor allele G of rs10178256 might abolish the binding of MESP1 and MESP2 which play vital roles in bone homeostasis, whereas the minor allele G of rs6214 might create an additional ..
  23. doi Molecular analyses of Xenopus laevis Mesp-related genes
    Keisuke Hitachi
    Department of Life Sciences Biology, Graduate School of Arts and Sciences, The University of Tokyo, Meguro ku, Tokyo, Japan
    Integr Zool 4:387-94. 2009
    ..Among vertebrates, two types of Mesp-related genes have been identified: Mesp1 and Mesp2 in the mouse; Meso-1 and Meso-2 in the chicken; Xl-mespa and Xl-mespb (also known as Thylacine1) in the African ..
  24. doi Clinical and radiological distinction between spondylothoracic dysostosis (Lavy-Moseley syndrome) and spondylocostal dysostosis (Jarcho-Levin syndrome)
    Walter E Berdon
    Department of Radiology, Columbia University College of Physicians and Surgeons, Morgan Stanley Children s Hospital of New York Presbyterian, New York, NY, USA
    Pediatr Radiol 41:384-8. 2011
    ..severe respiratory compromise, is largely linked to Puerto Rican cohorts and is thought to be associated to the MESP2 gene, also a Notch pathway gene...
  25. doi The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis
    Nobuo Sasaki
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Development 138:55-64. 2011
    ..of Notch signaling is essential for the establishment of rostro-caudal polarity within a somite and that Mesp2 acts as a novel negative regulator of the Notch signaling pathway...
  26. ncbi Defective somitogenesis and abnormal vertebral segmentation in man
    Peter D Turnpenny
    Clinical Genetics Department, Royal Devon and Exeter Hospital, Gladstone Road, Exeter EX1 2ED, United Kingdom
    Adv Exp Med Biol 638:164-89. 2008
    ..Only a minority of abnormal segmentation phenotypes appear to follow Mendelian inheritance but three genes--DLL3, MESP2 and LNFG--have now been identified for spondylocostal dysostosis (SCD), a spinal malformation characterized by ..
  27. ncbi Mesp-family genes are required for segmental patterning and segmental border formation
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Adv Exp Med Biol 638:113-23. 2008
    ..In this process, Mesp2, another basic HLH protein plays a critical role...
  28. doi Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis
    Charalampos Rallis
    Developmental Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 4LY, UK
    Development 137:3591-601. 2010
    ..The two signalling pathways then cooperate to promote somite formation via cMESO1/Mesp2. Our results show that β1-integrin can regulate cell shape and tissue morphogenesis indirectly, by regulation of ..
  29. doi Autosomal dominant spondylocostal dysostosis in three generations of a Macedonian family: Negative mutation analysis of DLL3, MESP2, HES7, and LFNG
    Zoran S Gucev
    Medical Faculty Skopje, Divizija BB, Skopje, Macedonia
    Am J Med Genet A 152:1378-82. 2010
    ..SDV, a broadly symmetrical thoracic cage, and result from mutations in Notch signaling pathway genes-DLL3, MESP2, LFNG, and HES7...
  30. doi Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite
    Jun Takahashi
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Dev Biol 342:134-45. 2010
    ..In the mouse, Mesp2 is required for the rostral property whereas Notch signaling and Ripply2, a Mesp2-induced protein that suppresses ..
  31. doi The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 137:1515-22. 2010
    ..Surprisingly, this mouse also showed a normal rostral-caudal compartment within a somite, conferred by a normal Mesp2 expression pattern with a rostral-caudal gradient...
  32. ncbi Disruption of the somitic molecular clock causes abnormal vertebral segmentation
    Duncan B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
    Birth Defects Res C Embryo Today 81:93-110. 2007
    ..that spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway...
  33. ncbi Abnormal vertebral segmentation and the notch signaling pathway in man
    Peter D Turnpenny
    Clinical Genetics, Royal Devon and Exeter Hospital, and Peninsula Medical School, Exeter, United Kingdom
    Dev Dyn 236:1456-74. 2007
    ..Only rarely do AVS phenotypes follow clear Mendelian inheritance, but three genes-DLL3, MESP2, and LNFG-have now been identified for spondylocostal dysostosis (SCD)...
  34. ncbi Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, U L B, Brussels, Belgium
    Dev Dyn 236:1495-508. 2007
    ..in the levels of FGF and RA signaling, which permit the synchronized activation of segmentation genes, such as mesp2, in successive cohorts of PSM cells in response to the segmentation clock, thereby defining the future segments...
  35. ncbi Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 130:4259-68. 2003
    ..Notch signal pathways with Notch ligands Dll1 and Dll3, and the transcription factor Mesp2 are implicated in the rostrocaudal patterning of the somite...
  36. ncbi The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis
    Jerry Rhee
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Dev Biol 254:248-61. 2003
    ..Inactivation of the transcription factor Mesp2, or components of the Notch signaling pathway, led to defects in segmentation and a loss of anterior/posterior ..
  37. ncbi Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis
    Aya Nomura-Kitabayashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagaya Ku, Tokyo 158 8501, Japan
    Development 129:2473-81. 2002
    A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice...
  38. ncbi Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development
    S Haraguchi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagaya Ku, Tokyo 158 8501, Japan
    Mech Dev 108:59-69. 2001
    Mesp1 and Mesp2 encode bHLH-type transcription factors, Mesp1 and Mesp2, respectively. The expression of both genes is observed in the nascent mesoderm, and subsequently in the rostral presomitic mesoderm...
  39. pmc The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 15:2470-82. 2001
    ..that Foxc1 and Foxc2 are both required for transcription in the anterior presomitic mesoderm of paraxis, Mesp1, Mesp2, Hes5, and Notch1, and for the formation of sharp boundaries of Dll1, Lfng, and ephrinB2 expression...
  40. ncbi The role of presenilin 1 during somite segmentation
    K Koizumi
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Development 128:1391-402. 2001
    ..genes involved in the Notch signalling pathway was altered, including Delta-like3, Hes5, lunatic fringe (Lfng) and Mesp2. Thus, Ps1-dependent activation of the Notch pathway is essential for caudal half somite development...
  41. ncbi The anterior/posterior polarity of somites is disrupted in paraxis-deficient mice
    J Johnson
    Department of Biology, Arizona State University, Tempe, Arizona 85287 1501, USA
    Dev Biol 229:176-87. 2001
    ..is established at the anterior end of the presomitic mesoderm prior to overt somitogenesis in response to both Mesp2 and Notch signaling...
  42. ncbi The development of the avian vertebral column
    B Christ
    Institute of Anatomy, University of Freiburg, Germany
    Anat Embryol (Berl) 202:179-94. 2000
    ..in the cranial part of the segmental plate and accompanied by the expression of genes like Delta1, Mesp1, Mesp2, Ulicx-1, and EphA4 which are restricted to one half of the prospective somite...
  43. ncbi Mesp2 initiates somite segmentation through the Notch signalling pathway
    Y Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Nat Genet 25:390-6. 2000
    ..In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra...
  44. ncbi MesP1 and MesP2 are essential for the development of cardiac mesoderm
    S Kitajima
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Development 127:3215-26. 2000
    The transcription factors, MesP1 and MesP2, sharing an almost identical bHLH motif, have an overlapping expression pattern during gastrulation and somitogenesis...
  45. ncbi The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes
    J K Yoon
    Division of Biology, 156 29, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 222:376-91. 2000
    ..rostral to the pMesogenin1 domain strongly upregulate expression of pMesogenin's closest known paralogs, MesP1 and MesP2 (Thylacine1/2 in Xenopus)...
  46. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999
    ....
  47. ncbi Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement
    Y Saga
    Banyu Tsukuba Research Institute Merck, Tsukuba, 300 26, Japan
    Mech Dev 75:53-66. 1998
    ..MesP1 belongs to the same family of bHLH transcription factors as MesP2. The early expression pattern observed in the early mesoderm at the onset of gastrulation is restricted to Mesp1, ..
  48. pmc Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
    D A Kenny
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0650, USA
    Proc Natl Acad Sci U S A 95:11257-62. 1998
    ..LMO4 expression in somite is repressed in mice mutant for the segment polarity gene Mesp2 and expanded in Splotch mutants...
  49. ncbi Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening
    Andrew S McLellan
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Mech Dev 119:S285-91. 2002
    ..Thus, we are now approaching an almost complete listing of human class II bHLH factors...
  50. pmc Mutated MESP2 causes spondylocostal dysostosis in humans
    Neil V Whittock
    Institute of Biomedical and Clinical Science, Royal Devon and Exeter Hospital, Exeter EX2 5DW, United Kingdom
    Am J Hum Genet 74:1249-54. 2004
    ..3-15q26.1 and furthermore identified a 4-bp duplication mutation in the human MESP2 gene that codes for a basic helix-loop-helix transcription factor...
  51. ncbi Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagayaku, Tokyo, Japan
    Dev Dyn 236:1484-94. 2007
    b>Mesp2 and Paraxis are basic helix-loop-helix (bHLH) -type transcription factors coexpressed in the presomitic mesoderm (PSM) and are required for normal somite formation...
  52. ncbi Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, and Department of Genetics, SOKENDAI, Mishima, Japan
    Dev Dyn 236:1450-5. 2007
    ..During this process, Mesp2, another basic HLH protein, plays a critical role in the anterior PSM...
  53. ncbi The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 134:1561-9. 2007
    The Mesp2 transcription factor plays essential roles in segmental border formation and in the establishment of rostro-caudal patterning within a somite...
  54. pmc Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells
    Yu Liu
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:3859-64. 2007
    ..cardiac myogenesis selectively, acting subsequent to mesoderm formation yet before induction of Mesp1 and Mesp2, a pair of related basic helix-loop-helix transcription factors that together are indispensable for creating heart ..
  55. ncbi Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Dev Biol 304:593-603. 2007
    Mesp1 and Mesp2 are homologous transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) during mouse somitogenesis...
  56. ncbi Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Dev Biol 300:687-98. 2006
    b>Mesp2 is a bHLH-type transcription factor that plays a key role during somitogenesis. Mesp2 is transiently expressed and is quickly degraded once translated...
  57. ncbi Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2
    Yoshiro Nakajima
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:2517-25. 2006
    ..A crucial protein for segment border formation is the bHLH transcription factor Mesp2, the expression of which is restricted to the anterior PSM...
  58. pmc Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression
    Yukuto Yasuhiko
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya Ku, Tokyo 158 8501, Japan
    Proc Natl Acad Sci U S A 103:3651-6. 2006
    b>Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation...
  59. ncbi Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1
    Jihua Chen
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA
    Gene Expr Patterns 6:376-82. 2006
    ..Four of these genes were altered in expression pattern or expression level. The Notch target genes Hes5 and Mesp2 were affected to some degree in all mutant embryos...
  60. pmc Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
    D B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia
    Am J Hum Genet 78:28-37. 2006
    ..we had identified two genes that cause a subset of autosomal recessive forms of this disease: DLL3 (SCD1) and MESP2 (SCD2)...
  61. ncbi The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
    Nature 435:354-9. 2005
    ..studies indicate that this interface is generated by suppression of Notch activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe gene (Lfng)...
  62. ncbi Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 132:787-96. 2005
    Mesp1 and Mesp2 are homologous basic helix-loop-helix (bHLH) transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) just prior to somite formation...
  63. ncbi Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes
    Kenro Kusumi
    Divisions of Human Genetics and Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genesis 39:115-21. 2004
    ..mutation has different effects on the expression of cycling (Lfng and Hes7) and stage-specific genes (Hey3 and Mesp2)...
  64. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..AP-somite polarity is generated in the anterior presomitic mesoderm by Mesp2 and Delta/Notch signaling...
  65. ncbi Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation
    Y Saga
    Banyu Tsukuba Research Institute Merck, Japan
    Genes Dev 11:1827-39. 1997
    We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm...