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Genomes and Genes
| MESP2SummaryGene Symbol: MESP2 Description: mesoderm posterior 2 homolog (mouse) Alias: SCDO2, bHLHc6, class C basic helix-loop-helix protein 6, mesoderm posterior protein 2 Species: human Top Publications
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Publications
Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosisXu Sheng Qiu
Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Stud Health Technol Inform 176:52-5. 2012b>MESP2, HES7 and DUSP6 genes have been proved to be involved in the etiopathogenesis of congenital scoliosis (CS) in animal embryo studies, however, whether this association was detected in human CS patients also remains unknown...
Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosisDuncan B Sparrow
Developmental Biology Division, Victor ChangCardiac Research Institute, Darlinghurst, Sydney, NSW, Australia
Hum Mol Genet 17:3761-6. 2008..a subset of autosomal recessive forms of this disease have been identified: DLL3 (SCDO1: MIM 277300), MESP2 (SCDO2: MIM 608681) and LFNG (SCDO3: MIM609813)...- T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesodermHenner F Farin
Institute for Molecular Biology, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Strasse 1, Hannover, Germany
J Biol Chem 283:25372-80. 2008..Anterior-posterior somite polarity is generated in the anterior presomitic mesoderm by Mesp2 and Delta/Notch signaling and is further maintained by two transcriptional regulators, Uncx4... - Spondylocostal dysostosis in a pregnancy complicated by confined placental mosaicism for tetrasomy 9pDavid Coman
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
Am J Med Genet A 146:1972-6. 2008..Testing of the genes DLL3, MESP2, and LFNG did not identify a mutation, suggesting that the siblings may have a new molecular subtype of SCD. - Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesisMasayuki Oginuma
Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka, Japan
Development 135:2555-62. 2008..The transcription factor Mesp2 plays a crucial role in this process, regulating segmental border formation and rostro-caudal patterning... - Physical interaction between Tbx6 and mespb is indispensable for the activation of bowline expression during Xenopus somitogenesisKeisuke Hitachi
Department of Life Sciences Biology, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
Biochem Biophys Res Commun 372:607-12. 2008..signaling crosstalk that occurs between two major transcription factors involved in somitogenesis, Tbx6 and mespb/mesp2. These factors synergistically activated the expression of a downstream gene, bowline/Ripply2, which is essential .. 
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndromeAlberto S Cornier
Department of Molecular Medicine, La Concepcion Hospital, San German, PR 00683, USA
Am J Hum Genet 82:1334-41. 2008..in mouse segmentation, we identified a recessive E103X nonsense mutation in the mesoderm posterior 2 homolog (MESP2) gene in a patient, of Puerto Rican origin and from the Boston area, who had been diagnosed with STD/JLS...- Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technologyMasayuki Oginuma
Department of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
Mech Dev 125:432-40. 2008..Using this method, we have analyzed the Mesp1 and/or Mesp2 enhancers and identified P1-PSME, a PSM-specific enhancer of Mesp1, which contains a T-box binding site similar to .. - Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentationWilliam C Dunty
Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
Development 135:85-94. 2008..The Wnt3a/beta-catenin pathway does so by regulating the activation of the segment boundary determination genes Mesp2 and Ripply2 in the PSM through the activation of the Notch ligand Dll1 and the mesodermal transcription factors T .. - Disruption of the somitic molecular clock causes abnormal vertebral segmentationDuncan B Sparrow
Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
Birth Defects Res C Embryo Today 81:93-110. 2007..that spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway... - Abnormal vertebral segmentation and the notch signaling pathway in manPeter D Turnpenny
Clinical Genetics, Royal Devon and Exeter Hospital, and Peninsula Medical School, Exeter, United Kingdom
Dev Dyn 236:1456-74. 2007..Only rarely do AVS phenotypes follow clear Mendelian inheritance, but three genes-DLL3, MESP2, and LNFG-have now been identified for spondylocostal dysostosis (SCD)... - Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signalingAlbert Goldbeter
Faculte des Sciences, Universite Libre de Bruxelles, U L B, Brussels, Belgium
Dev Dyn 236:1495-508. 2007..in the levels of FGF and RA signaling, which permit the synchronized activation of segmentation genes, such as mesp2, in successive cohorts of PSM cells in response to the segmentation clock, thereby defining the future segments... - Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formationYu Takahashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagayaku, Tokyo, Japan
Dev Dyn 236:1484-94. 2007b>Mesp2 and Paraxis are basic helix-loop-helix (bHLH) -type transcription factors coexpressed in the presomitic mesoderm (PSM) and are required for normal somite formation... - Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2Yukuto Yasuhiko
Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Development 135:3511-9. 2008The T-box transcription factor Tbx6 controls the expression of Mesp2, which encodes a basic helix-loop-helix transcription factor that has crucial roles in somitogenesis... - EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentationTadayoshi Watanabe
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0192, Japan
Proc Natl Acad Sci U S A 106:7467-72. 2009..We here demonstrate that cMeso-1, the chicken homolog of mouse Mesp2, up-regulates EphA4 in the cells located posteriorly to a forming boundary... - The role of Notch in patterning the human vertebral columnSally L Dunwoodie
Developmental Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010 Sydney, Australia
Curr Opin Genet Dev 19:329-37. 2009..More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans... - A genome-wide survey on basic helix-loop-helix transcription factors in giant pandaChunwang Dang
Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, People s Republic of China
PLoS ONE 6:e26878. 2011..Compared to mouse, the giant panda does not encode seven bHLH proteins namely Beta3a, Mesp2, Sclerax, S-Myc, Hes5 (or Hes6), EBF4 and Orphan 1... - Identification of genes for bone mineral density variation by computational disease gene identification strategyGloria H Y Li
Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China
J Bone Miner Metab 29:709-16. 2011..factor binding suggested that the minor allele G of rs10178256 might abolish the binding of MESP1 and MESP2 which play vital roles in bone homeostasis, whereas the minor allele G of rs6214 might create an additional .. - Molecular analyses of Xenopus laevis Mesp-related genesKeisuke Hitachi
Department of Life Sciences Biology, Graduate School of Arts and Sciences, The University of Tokyo, Meguro ku, Tokyo, Japan
Integr Zool 4:387-94. 2009..Among vertebrates, two types of Mesp-related genes have been identified: Mesp1 and Mesp2 in the mouse; Meso-1 and Meso-2 in the chicken; Xl-mespa and Xl-mespb (also known as Thylacine1) in the African .. - Clinical and radiological distinction between spondylothoracic dysostosis (Lavy-Moseley syndrome) and spondylocostal dysostosis (Jarcho-Levin syndrome)Walter E Berdon
Department of Radiology, Columbia University College of Physicians and Surgeons, Morgan Stanley Children s Hospital of New York Presbyterian, New York, NY, USA
Pediatr Radiol 41:384-8. 2011..severe respiratory compromise, is largely linked to Puerto Rican cohorts and is thought to be associated to the MESP2 gene, also a Notch pathway gene... - The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesisNobuo Sasaki
Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
Development 138:55-64. 2011..of Notch signaling is essential for the establishment of rostro-caudal polarity within a somite and that Mesp2 acts as a novel negative regulator of the Notch signaling pathway... - Defective somitogenesis and abnormal vertebral segmentation in manPeter D Turnpenny
Clinical Genetics Department, Royal Devon and Exeter Hospital, Gladstone Road, Exeter EX1 2ED, United Kingdom
Adv Exp Med Biol 638:164-89. 2008..Only a minority of abnormal segmentation phenotypes appear to follow Mendelian inheritance but three genes--DLL3, MESP2 and LNFG--have now been identified for spondylocostal dysostosis (SCD), a spinal malformation characterized by .. - Mesp-family genes are required for segmental patterning and segmental border formationYumiko Saga
Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
Adv Exp Med Biol 638:113-23. 2008..In this process, Mesp2, another basic HLH protein plays a critical role... - Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesisCharalampos Rallis
Developmental Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 4LY, UK
Development 137:3591-601. 2010..The two signalling pathways then cooperate to promote somite formation via cMESO1/Mesp2. Our results show that β1-integrin can regulate cell shape and tissue morphogenesis indirectly, by regulation of .. - Autosomal dominant spondylocostal dysostosis in three generations of a Macedonian family: Negative mutation analysis of DLL3, MESP2, HES7, and LFNGZoran S Gucev
Medical Faculty Skopje, Divizija BB, Skopje, Macedonia
Am J Med Genet A 152:1378-82. 2010..SDV, a broadly symmetrical thoracic cage, and result from mutations in Notch signaling pathway genes-DLL3, MESP2, LFNG, and HES7... - Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somiteJun Takahashi
Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
Dev Biol 342:134-45. 2010..In the mouse, Mesp2 is required for the rostral property whereas Notch signaling and Ripply2, a Mesp2-induced protein that suppresses .. - The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somiteMasayuki Oginuma
Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Development 137:1515-22. 2010..Surprisingly, this mouse also showed a normal rostral-caudal compartment within a somite, conferred by a normal Mesp2 expression pattern with a rostral-caudal gradient... - Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosisDuncan B Sparrow
Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
Eur J Hum Genet 18:674-9. 2010..a subset of autosomal recessive forms of this disease have been identified: DLL3 (SCDO1: MIM 277300), MESP2 (SCDO2: MIM 608681), LFNG (SCDO3: MIM609813) and HES7 (SCDO4)... - Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activityYumiko Saga
Division of Mammalian Development, National Institute of Genetics, and Department of Genetics, SOKENDAI, Mishima, Japan
Dev Dyn 236:1450-5. 2007..During this process, Mesp2, another basic HLH protein, plays a critical role in the anterior PSM... - The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somiteMitsuru Morimoto
Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
Development 134:1561-9. 2007The Mesp2 transcription factor plays essential roles in segmental border formation and in the establishment of rostro-caudal patterning within a somite... - Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesisAya Nomura-Kitabayashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagaya Ku, Tokyo 158 8501, Japan
Development 129:2473-81. 2002A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice... - Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during developmentS Haraguchi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagaya Ku, Tokyo 158 8501, Japan
Mech Dev 108:59-69. 2001Mesp1 and Mesp2 encode bHLH-type transcription factors, Mesp1 and Mesp2, respectively. The expression of both genes is observed in the nascent mesoderm, and subsequently in the rostral presomitic mesoderm... - The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesisT Kume
Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Genes Dev 15:2470-82. 2001..that Foxc1 and Foxc2 are both required for transcription in the anterior presomitic mesoderm of paraxis, Mesp1, Mesp2, Hes5, and Notch1, and for the formation of sharp boundaries of Dll1, Lfng, and ephrinB2 expression... - The role of presenilin 1 during somite segmentationK Koizumi
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
Development 128:1391-402. 2001..genes involved in the Notch signalling pathway was altered, including Delta-like3, Hes5, lunatic fringe (Lfng) and Mesp2. Thus, Ps1-dependent activation of the Notch pathway is essential for caudal half somite development... - The anterior/posterior polarity of somites is disrupted in paraxis-deficient miceJ Johnson
Department of Biology, Arizona State University, Tempe, Arizona 85287 1501, USA
Dev Biol 229:176-87. 2001..is established at the anterior end of the presomitic mesoderm prior to overt somitogenesis in response to both Mesp2 and Notch signaling... - The development of the avian vertebral columnB Christ
Institute of Anatomy, University of Freiburg, Germany
Anat Embryol (Berl) 202:179-94. 2000..in the cranial part of the segmental plate and accompanied by the expression of genes like Delta1, Mesp1, Mesp2, Ulicx-1, and EphA4 which are restricted to one half of the prospective somite... - Mesp2 initiates somite segmentation through the Notch signalling pathwayY Takahashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
Nat Genet 25:390-6. 2000..In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra... - MesP1 and MesP2 are essential for the development of cardiac mesodermS Kitajima
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
Development 127:3215-26. 2000The transcription factors, MesP1 and MesP2, sharing an almost identical bHLH motif, have an overlapping expression pattern during gastrulation and somitogenesis... - The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypesJ K Yoon
Division of Biology, 156 29, California Institute of Technology, Pasadena, California, 91125, USA
Dev Biol 222:376-91. 2000..rostral to the pMesogenin1 domain strongly upregulate expression of pMesogenin's closest known paralogs, MesP1 and MesP2 (Thylacine1/2 in Xenopus)... - Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouseI B Barrantes
Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
Curr Biol 9:470-80. 1999.... - Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacementY Saga
Banyu Tsukuba Research Institute Merck, Tsukuba, 300 26, Japan
Mech Dev 75:53-66. 1998..MesP1 belongs to the same family of bHLH transcription factors as MesP2. The early expression pattern observed in the early mesoderm at the onset of gastrulation is restricted to Mesp1, .. - Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesisD A Kenny
Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0650, USA
Proc Natl Acad Sci U S A 95:11257-62. 1998..LMO4 expression in somite is repressed in mice mutant for the segment polarity gene Mesp2 and expanded in Splotch mutants... - The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesisJerry Rhee
Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
Dev Biol 254:248-61. 2003..Inactivation of the transcription factor Mesp2, or components of the Notch signaling pathway, led to defects in segmentation and a loss of anterior/posterior .. - Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somitesYu Takahashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
Development 130:4259-68. 2003..Notch signal pathways with Notch ligands Dll1 and Dll3, and the transcription factor Mesp2 are implicated in the rostrocaudal patterning of the somite... - Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screeningAndrew S McLellan
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
Mech Dev 119:S285-91. 2002..Thus, we are now approaching an almost complete listing of human class II bHLH factors... - Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cellsYu Liu
Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 104:3859-64. 2007..cardiac myogenesis selectively, acting subsequent to mesoderm formation yet before induction of Mesp1 and Mesp2, a pair of related basic helix-loop-helix transcription factors that together are indispensable for creating heart .. - Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formationYu Takahashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
Dev Biol 304:593-603. 2007Mesp1 and Mesp2 are homologous transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) during mouse somitogenesis... - Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axisMitsuru Morimoto
Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
Dev Biol 300:687-98. 2006b>Mesp2 is a bHLH-type transcription factor that plays a key role during somitogenesis. Mesp2 is transiently expressed and is quickly degraded once translated... - Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2Yoshiro Nakajima
Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
Development 133:2517-25. 2006..A crucial protein for segment border formation is the bHLH transcription factor Mesp2, the expression of which is restricted to the anterior PSM... - Tbx6-mediated Notch signaling controls somite-specific Mesp2 expressionYukuto Yasuhiko
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya Ku, Tokyo 158 8501, Japan
Proc Natl Acad Sci U S A 103:3651-6. 2006b>Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation... - Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1Jihua Chen
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA
Gene Expr Patterns 6:376-82. 2006..Four of these genes were altered in expression pattern or expression level. The Notch target genes Hes5 and Mesp2 were affected to some degree in all mutant embryos... - Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotypeD B Sparrow
Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia
Am J Hum Genet 78:28-37. 2006..we had identified two genes that cause a subset of autosomal recessive forms of this disease: DLL3 (SCD1) and MESP2 (SCD2)... - The Mesp2 transcription factor establishes segmental borders by suppressing Notch activityMitsuru Morimoto
Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
Nature 435:354-9. 2005..studies indicate that this interface is generated by suppression of Notch activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe gene (Lfng)... - Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somitesYu Takahashi
Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
Development 132:787-96. 2005Mesp1 and Mesp2 are homologous basic helix-loop-helix (bHLH) transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) just prior to somite formation... - Dll3 pudgy mutation differentially disrupts dynamic expression of somite genesKenro Kusumi
Divisions of Human Genetics and Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Genesis 39:115-21. 2004..mutation has different effects on the expression of cycling (Lfng and Hes7) and stage-specific genes (Hey3 and Mesp2)... - The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartmentsMarkus Bussen
Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
Genes Dev 18:1209-21. 2004..AP-somite polarity is generated in the anterior presomitic mesoderm by Mesp2 and Delta/Notch signaling... - Mutated MESP2 causes spondylocostal dysostosis in humansNeil V Whittock
Institute of Biomedical and Clinical Science, Royal Devon and Exeter Hospital, Exeter EX2 5DW, United Kingdom
Am J Hum Genet 74:1249-54. 2004..3-15q26.1 and furthermore identified a 4-bp duplication mutation in the human MESP2 gene that codes for a basic helix-loop-helix transcription factor... - Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiationY Saga
Banyu Tsukuba Research Institute Merck, Japan
Genes Dev 11:1827-39. 1997We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm...