MERTK

Summary

Gene Symbol: MERTK
Description: MER proto-oncogene, tyrosine kinase
Alias: MER, RP38, Tyro12, c-Eyk, c-mer, tyrosine-protein kinase Mer, MER receptor tyrosine kinase, STK kinase, c-mer proto-oncogene tyrosine kinase, proto-oncogene c-Mer, receptor tyrosine kinase MerTK
Species: human
Products:     MERTK

Top Publications

  1. Cosemans J, van Kruchten R, Olieslagers S, Schurgers L, Verheyen F, Munnix I, et al. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost. 2010;8:1797-808 pubmed publisher
    Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3, Axl and Mer (TAM) plays an important role in arterial thrombus formation. However, a role for Gas6 in human platelet activation has been questioned...
  2. Graham D, Salzberg D, Kurtzberg J, Sather S, Matsushima G, Keating A, et al. Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Clin Cancer Res. 2006;12:2662-9 pubmed
    The Mer receptor tyrosine kinase, cloned from a B-lymphoblastoid library, is the mammalian orthologue of the chicken retroviral oncogene v-eyk and sends antiapoptotic and transforming signals when activated...
  3. Uehara H, Shacter E. Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells. J Immunol. 2008;180:2522-30 pubmed
    ..disulfide-linked dimers and oligomers that preferentially bind to and activate the human Mer tyrosine kinase (MerTK) receptor on the macrophages...
  4. Ling L, Templeton D, Kung H. Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. J Biol Chem. 1996;271:18355-62 pubmed
    Nyk/Mer receptor tyrosine kinase is a new member of the Ufo/Axl tyrosine kinase family and is characterized by its neural cell adhesion molecule-like extracellular domain...
  5. Caberoy N, Zhou Y, Li W. Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 2010;29:3898-910 pubmed publisher
    ..Here, we characterized them as novel MerTK ligands to facilitate phagocytosis...
  6. Shiozawa Y, Pedersen E, Taichman R. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp Hematol. 2010;38:132-40 pubmed publisher
    ..In this study, we examined the roles of growth arrest-specific-6 (GAS6)/Mer axis in the interactions between E2A/PBX1-positive B-cell precursor ALL cells and the osteoblastic niche in the ..
  7. Wu Y, Singh S, Georgescu M, Birge R. A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci. 2005;118:539-53 pubmed
    ..Recognition of PS occurs either directly, via PS receptor (PS-R), or indirectly via alphavbeta5(3) integrin or Mer-family tyrosine kinases through the opsonizing proteins milk fat globule-EGF factor 8 protein (MFG-E8), or growth ..
  8. Migdall Wilson J, Bates C, Schlegel J, BRANDAO L, Linger R, DeRyckere D, et al. Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus. PLoS ONE. 2012;7:e31635 pubmed publisher
    b>Mer tyrosine kinase is ectopically expressed in acute lymphoblastic leukemia and associated with enhanced chemoresistance and disease progression...
  9. Graham D, Dawson T, Mullaney D, Snodgrass H, Earp H. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 1994;5:647-57 pubmed
    ..to name another tyrosine kinase and an analysis of RNA expression demonstrated that this novel human kinase is expressed in monocytes and tissues of epithelial and reproductive origin, we have designated our novel protooncogene c-mer.

More Information

Publications89

  1. Charbel Issa P, Bolz H, Ebermann I, Domeier E, Holz F, Scholl H. Characterisation of severe rod-cone dystrophy in a consanguineous family with a splice site mutation in the MERTK gene. Br J Ophthalmol. 2009;93:920-5 pubmed publisher
    ..2189+1G>T in the tyrosine kinase receptor gene MERTK. Five affected children of a consanguineous Moroccan family were investigated by ophthalmic examinations, ..
  2. Linger R, Cohen R, Cummings C, Sather S, Migdall Wilson J, Middleton D, et al. Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene. 2013;32:3420-31 pubmed publisher
    ..We evaluated 88 human NSCLC tumors of diverse histology and identified Mer and Axl as receptor tyrosine kinases (RTKs) overexpressed in 69% and 93%, respectively, of tumors relative to ..
  3. McHenry C, Liu Y, Feng W, Nair A, Feathers K, Ding X, et al. MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. Invest Ophthalmol Vis Sci. 2004;45:1456-63 pubmed
    Mutations in the MERTK gene are responsible for retinal degeneration in the Royal College of Surgeons (RCS) rat and are a cause of human autosomal recessive retinitis pigmentosa (RP)...
  4. Schlegel J, Sambade M, Sather S, Moschos S, Tan A, Winges A, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013;123:2257-67 pubmed publisher
    ..C-MER proto-oncogene tyrosine kinase (MERTK) is a receptor tyrosine kinase with oncogenic properties that is often overexpressed or activated in various ..
  5. Mahajan N, Earp H. An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. J Biol Chem. 2003;278:42596-603 pubmed
    b>Mer belongs to the Mer/Axl/Tyro3 receptor tyrosine kinase family, which regulates immune homeostasis in part by triggering monocyte ingestion of apoptotic cells...
  6. Tibrewal N, Wu Y, D Mello V, Akakura R, George T, Varnum B, et al. Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activati. J Biol Chem. 2008;283:3618-27 pubmed
    ..The Mer (Nyk and c-Eyk) receptor tyrosine kinase (Mertk) is involved in two aspects of apoptotic cell clearance by acting as a receptor for Gas6, a gamma-carboxylated ..
  7. Tada A, Wada Y, Sato H, Itabashi T, Kawamura M, Tamai M, et al. Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. Mol Vis. 2006;12:441-4 pubmed
    To determine whether mutations in the MERTK gene are present in Japanese patients with autosomal recessive retinitis pigmentosa (arRP)...
  8. Linger R, Keating A, Earp H, Graham D. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res. 2008;100:35-83 pubmed publisher
    Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs) characterized by a conserved sequence within the kinase domain and adhesion molecule-like extracellular domains...
  9. Sather S, Kenyon K, Lefkowitz J, Liang X, Varnum B, Henson P, et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood. 2007;109:1026-33 pubmed
    ..b>Mertk (Mer) is in a receptor tyrosine kinase family with Axl and Tyro-3, and all 3 receptors share the Gas6 ligand...
  10. Weinger J, Omari K, Marsden K, Raine C, Shafit Zagardo B. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am J Pathol. 2009;175:283-93 pubmed publisher
    ..protein 6 (Gas6), the ligand for the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl, and Mer, is important for cell growth, survival, and clearance of debris...
  11. Karl M, Kroeger W, Wimmers S, Milenkovic V, Valtink M, Engelmann K, et al. Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium. Cell Signal. 2008;20:1159-68 pubmed publisher
    Mutation or loss of MerTK as well as deficiency of alphavbeta5-integrins, gives rise to retinal-degeneration due to inefficient phagocytosis of photoreceptor outer-segment fragments by the retinal pigment epithelium (RPE)...
  12. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem. 1996;271:30022-7 pubmed
    Axl, Sky, and Mer, members of an Axl/Sky receptor tyrosine kinase subfamily, are typified by the cell adhesion molecule-related extracellular domain...
  13. Gal A, Li Y, Thompson D, Weir J, Orth U, Jacobson S, et al. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet. 2000;26:270-1 pubmed
    Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration...
  14. Thompson D, McHenry C, Li Y, Richards J, Othman M, Schwinger E, et al. Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet. 2002;70:224-9 pubmed
    ..of RPE65 (1p31) in one retinal dystrophy patient and an apparently homozygous loss-of-function mutation of MERTK (2q14.1) in a second retinal dystrophy patient...
  15. Zizzo G, Hilliard B, Monestier M, Cohen P. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012;189:3508-20 pubmed
    Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression correlates with poor prognosis in cancer...
  16. Mackay D, Henderson R, Sergouniotis P, Li Z, Moradi P, Holder G, et al. Novel mutations in MERTK associated with childhood onset rod-cone dystrophy. Mol Vis. 2010;16:369-77 pubmed
    ..phenotype in patients with a retinal dystrophy associated with novel mutations in the MER tyrosine kinase (MERTK) gene...
  17. Shahzadi A, Riazuddin S, Ali S, Li D, Khan S, Husnain T, et al. Nonsense mutation in MERTK causes autosomal recessive retinitis pigmentosa in a consanguineous Pakistani family. Br J Ophthalmol. 2010;94:1094-9 pubmed publisher
    ..analyses suggested that family PKRP173 was linked to chromosome 2q harbouring mer tyrosine kinase protooncogene (MERTK), a gene previously associated with autosomal recessive RP...
  18. Wu J, Ekman C, Jönsen A, Sturfelt G, Bengtsson A, Gottsäter A, et al. Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res Ther. 2011;13:R62 pubmed publisher
    b>Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family...
  19. Caberoy N, Alvarado G, Bigcas J, Li W. Galectin-3 is a new MerTK-specific eat-me signal. J Cell Physiol. 2012;227:401-7 pubmed publisher
    ..Here, we identified galectin-3 (Gal-3) as a new MerTK ligand by an advanced dual functional cloning strategy, in which phagocytosis-based functional cloning is combined ..
  20. Georgescu M, Kirsch K, Shishido T, Zong C, Hanafusa H. Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB. Mol Cell Biol. 1999;19:1171-81 pubmed
    The c-Mer receptor tyrosine kinase (RTK) is most closely related to chicken c-Eyk and belongs to the Axl RTK subfamily...
  21. Alciato F, Sainaghi P, Sola D, Castello L, Avanzi G. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J Leukoc Biol. 2010;87:869-75 pubmed publisher
    ..We evidenced that among GAS6 receptors, only Mer (but not Axl or Tyro3) is expressed on differentiated U937 cells, and its activation is responsible for the ..
  22. Garbin U, Baggio E, Stranieri C, Pasini A, Manfro S, Mozzini C, et al. Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?. Cardiovasc Res. 2013;97:125-33 pubmed publisher
    ..The cleavage of the extracellular domain of Mer tyrosine kinase (Mertk) by metallopeptidase domain17 (Adam17) has been shown to produce a soluble Mertk protein (sMer), which can inhibit ..
  23. Brandao L, Winges A, Christoph S, Sather S, Migdall Wilson J, Schlegel J, et al. Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia. Blood Cancer J. 2013;3:e101 pubmed publisher
    ..Thus, there is a continued need for new therapeutic options. Here, we show that mer receptor tyrosine kinase (MerTK) was abnormally expressed in approximately one half of pediatric T-cell leukemia patient samples ..
  24. Brea Fernández A, Pomares E, Brion M, Marfany G, Blanco M, Sanchez Salorio M, et al. Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. Br J Ophthalmol. 2008;92:1419-23 pubmed publisher
    Mutations in MERTK, a member of the MER/AXL/TYRO3 receptor kinase family, have been associated with disruption of the Retinal Pigment Epithelium (RPE) phagocytosis pathway and settling of autosomal recessive RP (arRP) in humans...
  25. Rives A, Baglai I, Barthes C, Maraval V, Saffon Merceron N, Saquet A, et al. Carbo-cyclohexadienes vs. carbo-benzenes: structure and conjugative properties. Chem Sci. 2015;6:1139-1149 pubmed publisher
    ..chromophores, constituted by two electro-active groups conjugated through the carbo-mer of the cyclohexa-1,3-diene core, are selectively prepared by the SnCl2-mediated reduction of tailored ..
  26. Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence M, Lior Hoffmann L, et al. Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases. J Biol Chem. 2016;291:23589-23603 pubmed
    ..DPCs containing full-length proteins (11-28 kDa) or a 23-mer peptide blocked human polymerases ? and ?...
  27. Korkmaz Zirpel N, Arslan T, Lee H. Engineering filamentous bacteriophages for enhanced gold binding and metallization properties. J Colloid Interface Sci. 2015;454:80-8 pubmed publisher
    ..In this study, Tyr containing 5-mer peptides were displayed on phage filaments for enhanced Au binding and reduction properties...
  28. Jose D, Weitzel S, Baase W, von Hippel P. Mapping the interactions of the single-stranded DNA binding protein of bacteriophage T4 (gp32) with DNA lattices at single nucleotide resolution: gp32 monomer binding. Nucleic Acids Res. 2015;43:9276-90 pubmed publisher
    ..backbone of this ssDNA oligomer, particularly at the 3'-end and facilitates base unstacking along the entire 8-mer lattice...
  29. Wedemeyer A, Kliemann L, Srivastav A, Schielke C, Reusch T, Rosenstiel P. An improved filtering algorithm for big read datasets and its application to single-cell assembly. BMC Bioinformatics. 2017;18:324 pubmed publisher
    ..An important new algorithmic feature is the use of phred quality scores together with a detailed analysis of the k-mer counts to decide which reads to keep. We qualify and recommend parameters for our new read filtering algorithm...
  30. Vouri M, Hafizi S. TAM Receptor Tyrosine Kinases in Cancer Drug Resistance. Cancer Res. 2017;77:2775-2778 pubmed publisher
    ..The TAM (Tyro3, Axl, Mer) subfamily of RTKs in particular feature in a variety of cancer types that have developed resistance to a broad ..
  31. Zhdanov D, Vasina D, Orlova E, Orlova V, Pokrovskaya M, Aleksandrova S, et al. [Apoptotic endonuclease EndoG regulates alternative splicing of human telomerase catalytic subunit hTERT]. Biomed Khim. 2016;62:544-554 pubmed publisher
    ..hTERT alternative splicing was induced by 47-mer RNA oligonucleotide in naked nuclei and in cells after transfection...
  32. Xiong S, Borrego P, Ding X, Zhu Y, Martins A, Chong H, et al. A Helical Short-Peptide Fusion Inhibitor with Highly Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2017;91: pubmed publisher
    ..T20 (enfuvirtide), a 36-mer peptide derived from the C-terminal heptad repeat region (CHR) of gp41, is the only clinically approved HIV-1 ..
  33. Bégin Lavallée V, Midavaine E, Dansereau M, Tétreault P, Longpre J, Jacobi A, et al. Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development. Mol Pain. 2016;12: pubmed publisher
    ..In the present study, we used 27-mer Dicer-substrate small interfering RNA (DsiRNA) targeting CCR2 and assessed their ability to reverse the nociceptive ..
  34. Eken C, Martin P, Sadallah S, Treves S, Schaller M, Schifferli J. Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages. J Biol Chem. 2010;285:39914-21 pubmed publisher
    ..The MerTK (Mer receptor tyrosine kinase) and PI3K/Akt pathways played a key role in this immunomodulatory effect as shown using specific MerTK-..
  35. Jacquot G, Lécorché P, Malcor J, Laurencin M, Smirnova M, Varini K, et al. Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor. Mol Pharm. 2016;13:4094-4105 pubmed
    ..J. Med. Chem. 2012, 55 (5), 2227). Initial chemical optimization of the 15-mer, all natural amino acid compound 1/VH411 (DSGL[CMPRLRGC]cDPR) and structure-activity relationship (SAR) ..
  36. Maeda I, Taniguchi S, Watanabe N, Inoue A, Yamasaki Y, Nose T. Design of Phenylalanine-Containing Elastin-Derived Peptides Exhibiting Highly Potent Self-Assembling Capability. Protein Pept Lett. 2015;22:934-9 pubmed
    ..to the native elastin-derived repeating peptide sequence ((Val-Pro-Gly-Val-Gly)10), one of the Phecontaining 5-mer repeating peptide sequences ((Phe-Pro-Gly-Val-Gly)5) clearly exhibited stronger coacervation properties...
  37. Jain P, Chakma B, Singh N, Patra S, Goswami P. Metal-DNA Interactions Improve signal in High-Resolution Melting of DNA for Species Differentiation of Plasmodium Parasite. Mol Biotechnol. 2017;59:179-191 pubmed publisher
    ..Conserved 26-mer ssDNAs from ldh gene of the four Plasmodium species were employed as targets...
  38. Wu J, Halter M, Kacker R, Elliott J, Plant A. A novel measure and significance testing in data analysis of cell image segmentation. BMC Bioinformatics. 2017;18:168 pubmed publisher
    ..The TER statistically aggregates all misclassification error rates (MER) by taking cell sizes as weights. The MERs are for segmenting each single cell in the population...
  39. Schrimpf A, Linne U, Geyer A. Eight at one stroke - a synthetic tetra-disulfide peptide epitope. Org Biomol Chem. 2017;15:2512-2521 pubmed publisher
    ..motifs, we are able to rationalise how the unbalanced number of bonded and non-bonded hydrogen pairs in a 12 mer hairpin causes their dimerisation...
  40. Lei Y, Yang F, Tang L, Chen K, Zhang G. Identification of Chinese Herbs Using a Sequencing-Free Nanostructured Electrochemical DNA Biosensor. Sensors (Basel). 2015;15:29882-92 pubmed publisher
    ..thunbergii and F. cirrhosa) were successfully discriminated at the DNA level, because a fragment of 16-mer sequence at the spacer region of the 5S-rRNA only exists in F. thunbergii...
  41. Roebuck J, Turkington J, Rogers D, Bailey P, Griffin V, Fischmann A, et al. Preorganized tridentate analogues of mixed hydroxyoxime/carboxylate nickel extractants. Dalton Trans. 2016;45:3734-42 pubmed publisher
    ..All are capable of forming octahedral [(L)2Ni] complexes with a mer-arrangement of the YNZ(-1) donor set...
  42. Zhou W, Ding J, Liu J. 2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver. Biosens Bioelectron. 2017;87:171-177 pubmed publisher
    ..In this work, 2-aminopurine (2AP) is used as a fluorescence label embedded in the middle of four 10-mer DNA homopolymers. 2AP can be quenched up to 98% in these DNA without an external quencher...
  43. Belzile C, Gosselin M. Free-living stage of the unicellular algae Coccomyxa sp. parasite of the blue mussel (Mytilus edulis): Low-light adaptation, capacity for growth at a very wide salinity range and tolerance to low pH. J Invertebr Pathol. 2015;: pubmed publisher
    ..In the present study, the growth of Coccomyxa sp. Metis-sur-mer (KJ372210) in liquid culture was investigated. Coccomyxa sp. maximum growth rate was 0...
  44. Xie S, Li Y, Li X, Wang L, Yang N, Wang Y, et al. Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib. Oncotarget. 2015;6:9206-19 pubmed
    b>Mer is a receptor tyrosine kinase (RTK) with oncogenic properties that is often overexpressed or activated in various malignancies...
  45. Wang Y, Li D, He M. Application of internal standard method in recombinant luminescent bacteria test. J Environ Sci (China). 2015;35:128-134 pubmed publisher
    ..The Mer gene is a mercury-responsive resistant gene, and a mercury-sensing recombinant luminescent bacterium using the Mer ..
  46. Kaczmarek A, Porebski P, Mortier T, Lynen F, Van Deun R, Van Hecke K. Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands. J Inorg Biochem. 2016;163:194-205 pubmed publisher
    ..The whole series of complexes was tested for their ability to cleave the 20-mer RNA oligonucleotide 5'-AGC-GAU-AAG-AUU-CAU-AUA-UC-3'...
  47. Mukherjee S, Wilhelm A, Antoniades C. TAM receptor tyrosine kinase function and the immunopathology of liver disease. Am J Physiol Gastrointest Liver Physiol. 2016;310:G899-905 pubmed publisher
    Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades...
  48. Saina M, Bi X, Lihana R, Lwembe R, Ishizaki A, Panikulam A, et al. Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children. PLoS ONE. 2015;10:e0137140 pubmed publisher
    ..4%, p = 0.045). Compared to RP, SP showed a significantly higher median number of predicted HLA-B-related 12-mer epitopes in Nef (3 vs. 2, p = 0.037), HLA-B-related 11-mer epitopes in Gag (2 vs. 1, p = 0...
  49. Grabiec A, Hussell T. The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation. Semin Immunopathol. 2016;38:409-23 pubmed publisher
    ..activation of apoptotic cell recognition receptors, such as the family of receptor tyrosine kinases Tyro3, Axl and MerTK (TAM), may delay or prevent inflammatory responses to subsequent infections...
  50. Lalinde E, Moreno M, Lara R, López I, Alfaro Arnedo E, Pichel J, et al. Benzothiazole Based Cycloplatinated Chromophores: Synthesis, Optical and Biological Studies. Chemistry. 2017;: pubmed publisher
    ..with concomitant deoxygenation of DMSO, under prolonged reaction with HCl(gas), to afford the PtIV dimethyl sulfide mer-[Pt(Me2N-pbt-?C,N)Cl3(SMe2)] mer-4, which evolves in solution to fac-4, as confirmed by X-ray...
  51. Heli H, Sattarahmady N, Hatam G, Reisi F, Vais R. An electrochemical genosensor for Leishmania major detection based on dual effect of immobilization and electrocatalysis of cobalt-zinc ferrite quantum dots. Talanta. 2016;156-157:172-179 pubmed publisher
    ..The quantum dots were then employed as an electrode modifier to immobilize a 24-mer specific single stranded DNA probe, and fabrication of a label-free, PCR-free and signal-on electrochemical ..
  52. Du X, Jiang C, Lv Y, Dull R, Zhao Y, Schwartz D, et al. Isoflurane promotes phagocytosis of apoptotic neutrophils through AMPK-mediated ADAM17/Mer signaling. PLoS ONE. 2017;12:e0180213 pubmed publisher
    ..Isoflurane significantly increased the surface expression of the receptor tyrosine kinase Mer in macrophages, but markedly decreased the levels of a soluble form of Mer protein in the medium...
  53. Mohan J, Kohler R, Hill J, Weissleder R, Mathis D, Benoist C. Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A. 2017;114:E7776-E7785 pubmed publisher
    ..Using advanced intravital imaging approaches and newly created reporter mice (Flt3-BFP2, Mertk-GFP-DTR, Cd4-tdTomato, Cd8a-tdTomato), we show that the autoimmune process initiates first with ..
  54. Al Khersan H, Shah K, Jung S, Rodriguez A, Madduri R, Grassi M. A novel MERTK mutation causing retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2017;255:1613-1619 pubmed publisher
    ..Sanger sequencing of MERTK was completed on the patient's unaffected mother, affected brother, and unaffected sister to determine genetic ..
  55. Tiet P, Clark K, McNamara J, Berlin J. Colorimetric Detection of Staphylococcus aureus Contaminated Solutions without Purification. Bioconjug Chem. 2017;28:183-193 pubmed publisher
    ..aureus with a colorimetric readout. We have functionalized a chemically modified 11-mer sequence onto AuNPs and have found that aggregation occurs in the presence of S. aureus supernantants...
  56. Melvin R, Gmeiner W, Salsbury F. All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer. Phys Chem Chem Phys. 2017;19:22363-22374 pubmed publisher
    ..One molecule of interest is a 10 mer of FdUMP (5-fluoro-2'-deoxyuridine-5'-O-monophosphate) - also called F10...
  57. Ruvolo P, Ma H, Ruvolo V, Zhang X, Mu H, Schober W, et al. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms. Haematologica. 2017;102:2048-2057 pubmed publisher
    ..ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase...
  58. Relizani K, Griffith G, Echevarría L, Zarrouki F, Facchinetti P, Vaillend C, et al. Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model. Mol Ther Nucleic Acids. 2017;8:144-157 pubmed publisher
    ..Herein, we report the efficacy and toxicology profile of a 13-mer tcDNA in mdx mice...
  59. Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014;192:3816-27 pubmed publisher
    ..this study, we examined the role of chemokines in the Abca4(-/-)Rdh8(-/-) mouse model of Stargardt disease and the Mertk(-/-) mouse model of retinitis pigmentosa. PCR array analysis of 84 chemokines and related molecules revealed 84...
  60. Farrukh A, Ortega F, Fan W, Marichal N, Paez J, Berninger B, et al. Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis. Stem Cell Reports. 2017;9:1432-1440 pubmed publisher
    ..Here, we address the effect of bifunctionalized hydrogels comprising polylysine (PL) and a 19-mer peptide containing the laminin motif IKVAV (IKVAV) on embryonic and adult neuronal progenitor cells under different ..
  61. Malygin A, Graifer D, Meschaninova M, Venyaminova A, Timofeev I, Kuzhelev A, et al. Structural rearrangements in mRNA upon its binding to human 80S ribosomes revealed by EPR spectroscopy. Nucleic Acids Res. 2017;: pubmed publisher
    The model mRNA (MR), 11-mer RNA containing two nitroxide spin labels at the 5'- and 3'-terminal nucleotides and prone to form a stable homodimer (MR)2, was used for Electron Paramagnetic Resonance study of structural rearrangements in ..
  62. Cross S, Potter J, Aldo P, Kwon J, Pitruzzello M, Tong M, et al. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. J Immunol. 2017;199:2885-2895 pubmed publisher
    ..that the mechanism by which this aggravated inflammation arises is through the inhibition of the TAM receptor, MERTK, and activation of the inflammasome...
  63. Yang W, Sinha S. A novel method for predicting activity of cis-regulatory modules, based on a diverse training set. Bioinformatics. 2017;33:1-7 pubmed publisher
    ..A popular approach to this task is to model the typical k-mer composition of a set of CRMs known to drive a common expression pattern, and assign that pattern to other CRMs ..
  64. Sharma B, Kanwar S. Phosphatidylserine: A cancer cell targeting biomarker. Semin Cancer Biol. 2018;52:17-25 pubmed publisher
    ..protein, phospholipid Saposin C dioleoylphosphatidylserine (SapC-DOPS), peptide-peptoid hybrid PPS1, PS-binding 14-mer peptide (PSBP-6) and hexapeptide (E3) have been reported to target PS present on cancer cell surface...
  65. Abante J, Ghaffari N, Johnson C, Datta A. HiMMe: using genetic patterns as a proxy for genome assembly reliability assessment. BMC Genomics. 2017;18:694 pubmed publisher
    ..Our results show that the method presented is able to recognize patterns even with relatively small k-mer size choices and limited computational resources...
  66. Welner S, Nielsen M, Rasmussen M, Buus S, Jungersen G, Larsen L. Prediction and in vitro verification of potential CTL epitopes conserved among PRRSV-2 strains. Immunogenetics. 2017;: pubmed publisher
    ..Briefly, all possible 9- and 10-mer peptides were generated from 104 complete PRRSV type 2 genomes of confirmed high quality, and peptides with high ..
  67. Yang Z, Mammel M, Papafragkou E, Hida K, Elkins C, Kulka M. Application of next generation sequencing toward sensitive detection of enteric viruses isolated from celery samples as an example of produce. Int J Food Microbiol. 2017;261:73-81 pubmed publisher
    ..as "unknowns" for data analyses using (i) a sequence-based alignment with a local database, (ii) an "in-house" k-mer tool, (iii) a commercially available metagenomics bioinformatic analysis platform cosmosID, and (iv) an open-source ..
  68. Xue G, Kohler R, Tang F, Hynx D, Wang Y, Orso F, et al. mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition. Oncotarget. 2017;8:69204-69218 pubmed publisher
    ..We conducted transcriptome gene profiling in BRAFi-treated melanoma cells and identified that Mer tyrosine kinase (MerTK) is specifically upregulated...
  69. Penberthy K, Rival C, Shankman L, Raymond M, Zhang J, Perry J, et al. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017;7:14623 pubmed publisher
    ..Loss of the PtdSer receptor Mertk is associated with apoptotic corpse accumulation in the testes and degeneration of photoreceptors in the eye...
  70. Taskova M, Madsen C, Jensen K, Hansen L, Vester B, Astakhova K. Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation. Bioconjug Chem. 2017;28:768-774 pubmed publisher
    ..We report the synthesis and internal double labeling of 21-mer oligonucleotides that target the BRAF V600E oncogene, with a library of rationally designed peptides employing ..
  71. Guo X, Leonard P, Ingale S, Seela F. Gemcitabine, Pyrrologemcitabine, and 2'-Fluoro-2'-Deoxycytidines: Synthesis, Physical Properties, and Impact of Sugar Fluorination on Silver Ion Mediated Base Pairing. Chemistry. 2017;23:17740-17754 pubmed publisher
    ..The nucleosides were converted into phosphoramidites and incorporated into 12-mer oligonucleotides by solid-phase synthesis...
  72. Zargarian L, Ben Imeddourene A, Gavvala K, Barthes N, Michel B, Kenfack C, et al. Structural and Dynamical Impact of a Universal Fluorescent Nucleoside Analogue Based on 3-Hydroxychromone Inserted Into a DNA Duplex. J Phys Chem B. 2017;: pubmed publisher
    ..Here, we investigated by NMR a 12-mer duplex, in which a central adenine was replaced by 3HCnt...
  73. Sankarasubramanian J, Vishnu U, Gunasekaran P, Rajendhran J. Identification of genetic variants of Brucella spp. through genome-wide association studies. Infect Genet Evol. 2017;56:92-98 pubmed publisher
    ..of 552 strains based on genome-wide single nucleotide polymorphisms (SNPs) determined by an alignment-free k-mer approach. A total of 138,029 SNPs were identified from 552 Brucella genomes...
  74. Musso G, Cassader M, De Michieli F, Paschetta E, Pinach S, Saba F, et al. MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat. Hum Mol Genet. 2017;26:1747-1758 pubmed publisher
    The loss-of-function rs4374383?G?>?A variant in Myeloid-epithelial-reproductive Tyrosine Kinase (MERTK) gene has been linked to hepatic fibrosis in chronic liver diseases...
  75. Fu X, Li J, Tian Y, Quan W, Zhang S, Liu Q, et al. Long-read sequence assembly of the firefly Pyrocoelia pectoralis genome. Gigascience. 2017;: pubmed publisher
    ..7% complete and 0.7% partial insect BUSCOs. The k-mer analysis showed this genome is highly heterozygous...
  76. Dillen L, Sips L, Greway T, Verhaeghe T. Quantitative analysis of imetelstat in plasma with LC-MS/MS using solid-phase or hybridization extraction. Bioanalysis. 2017;: pubmed publisher
    Imetelstat, a 13-mer oligonucleotide with a lipid tail is being evaluated for treating hematologic myeloid malignancies. This report describes the development of extraction and quantification methods for imetelstat...
  77. Uribe D, Mandell E, Watson A, Martinez J, Leighton J, Ghosh S, et al. The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PLoS ONE. 2017;12:e0179979 pubmed publisher
    The receptor tyrosine kinases (RTKs) TYRO3, AXL and MERTK (TAM) have well-described oncogenic functions in a number of cancers. Notwithstanding, TAM RTKs are also potent and indispensable inhibitors of inflammation...
  78. Wang M, Talbot J, Moore T. Drainage and fertilization effects on nutrient availability in an ombrotrophic peatland. Sci Total Environ. 2018;621:1255-1263 pubmed publisher
    ..peatland ecosystems and we examined spatial and temporal patterns of nutrient availability through ion exchange at Mer Bleue bog, southeast Ontario, Canada...
  79. Zhang L, Xu P, Cai Y, Ma L, Li S, Li S, et al. The draft genome assembly of Rhododendron delavayi Franch. var. delavayi. Gigascience. 2017;6:1-11 pubmed publisher
    ..delavayi var. delavayi genome (695.09 Mb) was close to the 697.94 Mb, estimated by k-mer analysis. A total of 336...
  80. Khund Sayeed S, He X, Holzberg T, Wang J, Rajagopal D, Upadhyay S, et al. 5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4. Integr Biol (Camb). 2016;8:936-45 pubmed publisher
    ..TCF4 preferentially bound the E-box motif (CAN|NTG) with strongest binding to the 8-mer CAG|GTGGT. 5mC uniformly decreases DNA binding of both TCF4 and USF1...