MEN1

Summary

Gene Symbol: MEN1
Description: menin 1
Alias: MEAI, SCG2, menin
Species: human
Products:     MEN1

Top Publications

  1. Heppner C, Kester M, Agarwal S, Debelenko L, Emmert Buck M, Guru S, et al. Somatic mutation of the MEN1 gene in parathyroid tumours. Nat Genet. 1997;16:375-8 pubmed
    ..Some cases are caused by inherited syndromes, such as multiple endocrine neoplasia type 1 (MEN1; ref. 2). In most cases, the molecular basis of parathyroid neoplasia is unknown...
  2. Sukhodolets K, Hickman A, Agarwal S, Sukhodolets M, Obungu V, Novotny E, et al. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol. 2003;23:493-509 pubmed
    b>Menin is a 70-kDa protein encoded by MEN1, the tumor suppressor gene disrupted in multiple endocrine neoplasia type 1...
  3. Agarwal S, Impey S, McWeeney S, Scacheri P, Collins F, Goodman R, et al. Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia. 2007;9:101-7 pubmed
    b>Menin is the protein product of the MEN1 tumor-suppressor gene; one allele of MEN1 is inactivated in the germ line of patients with "multiple endocrine neoplasia type 1" (MEN1) cancer syndrome...
  4. Agarwal S, Guru S, Heppner C, Erdos M, Collins R, Park S, et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell. 1999;96:143-52 pubmed
    MEN1 is a tumor suppressor gene that encodes a 610 amino acid nuclear protein (menin) of previously unknown function...
  5. Bazzi W, Renon M, Vercherat C, Hamze Z, Lacheretz Bernigaud A, Wang H, et al. MEN1 missense mutations impair sensitization to apoptosis induced by wild-type menin in endocrine pancreatic tumor cells. Gastroenterology. 2008;135:1698-1709.e2 pubmed publisher
    ..From the INS-1 insulinoma cell line, we established clones conditionally over expressing wild-type (WT) menin or its A160T, H317Y, and A541T variants...
  6. Wang Y, Ozawa A, Zaman S, Prasad N, Chandrasekharappa S, Agarwal S, et al. The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. Cancer Res. 2011;71:371-82 pubmed publisher
    ..Mutations in the MEN1 gene that encodes for the menin protein are the predominant cause for hereditary MEN1 syndrome...
  7. Drori Herishanu L, Horvath A, Nesterova M, Patronas Y, Lodish M, Bimpaki E, et al. An Intronic mutation is associated with prolactinoma in a young boy, decreased penetrance in his large family, and variable effects on MEN1 mRNA and protein. Horm Metab Res. 2009;41:630-4 pubmed publisher
    ..The IVS3-7 c>a defect is suggested to be pathogenic because it is associated with lower menin levels in the cells of these patients, but its consequences may be mitigated by a variety of factors including ..
  8. Schaaf L, Pickel J, Zinner K, Hering U, Hofler M, Goretzki P, et al. Developing effective screening strategies in multiple endocrine neoplasia type 1 (MEN 1) on the basis of clinical and sequencing data of German patients with MEN 1. Exp Clin Endocrinol Diabetes. 2007;115:509-17 pubmed
    Multiple-endocrine-neoplasia-type-1 (MEN1) is an autosomal-dominant inherited disorder characterized by the combined occurrence of primary hyperparathyroidism (pHPT), gastroenteropancreatic neuroendocrine tumors (GEP), adenomas of the ..
  9. Yokoyama A, Somervaille T, Smith K, Rozenblatt Rosen O, Meyerson M, Cleary M. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell. 2005;123:207-18 pubmed
    ..MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor gene, which is mutated in heritable and sporadic endocrine tumors...

More Information

Publications64

  1. Lemos M, Thakker R. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat. 2008;29:22-32 pubmed
    ..MEN1 gene, which was identified in 1997, consists of 10 exons that encode a 610-amino acid protein referred to as menin. Menin is predominantly a nuclear protein that has roles in transcriptional regulation, genome stability, cell ..
  2. Kim H, Lee J, Cho E, Liu J, Youn H. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res. 2003;63:6135-9 pubmed
    b>Menin, a gene product of multiple endocrine neoplasia type I (MEN1), is known to act as a tumor suppressor to repress JunD transcription factor...
  3. Stratakis C, Schussheim D, Freedman S, Keil M, Pack S, Agarwal S, et al. Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 2000;85:4776-80 pubmed
    ..The MEN1 gene, a tumor suppressor, is located on chromosome 11...
  4. Gallo A, Cuozzo C, Esposito I, Maggiolini M, Bonofiglio D, Vivacqua A, et al. Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation. Oncogene. 2002;21:6434-45 pubmed
    b>Menin, a nuclear protein encoded by the tumor suppressor gene MEN1, interacts with the AP-1 transcription factor JunD and inhibits its transcriptional activity. In addition, overexpression of Menin counteracts Ras-induced tumorigenesis...
  5. Chandrasekharappa S, Guru S, Manickam P, Olufemi S, Collins F, Emmert Buck M, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276:404-7 pubmed
    ..8-kilobase transcript. The predicted 610-amino acid protein product, termed menin, exhibits no apparent similarities to any previously known proteins...
  6. La P, Silva A, Hou Z, Wang H, Schnepp R, Yan N, et al. Direct binding of DNA by tumor suppressor menin. J Biol Chem. 2004;279:49045-54 pubmed
    b>Menin is a tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1), an inherited tumor-prone syndrome...
  7. Vierimaa O, Ebeling T, Kytola S, Bloigu R, Eloranta E, Salmi J, et al. Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation. Eur J Endocrinol. 2007;157:285-94 pubmed
    The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial...
  8. Turner J, Leotlela P, Pannett A, Forbes S, Bassett J, Harding B, et al. Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 2002;87:2688-93 pubmed
    b>MEN1 is an autosomal dominant disorder characterized by parathyroid, pituitary, and pancreatic tumors. The MEN1 gene is located on chromosome 11q13 and encodes a 610-amino acid protein...
  9. Chen G, A J, Wang M, Farley S, Lee L, Lee L, et al. Menin promotes the Wnt signaling pathway in pancreatic endocrine cells. Mol Cancer Res. 2008;6:1894-907 pubmed publisher
    b>Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia type 1. We show that menin is essential for canonical Wnt/beta-catenin signaling in cultured rodent islet tumor cells...
  10. Agarwal S, Ozawa A, Mateo C, Marx S. The MEN1 gene and pituitary tumours. Horm Res. 2009;71 Suppl 2:131-8 pubmed publisher
    Sporadic multiple endocrine neoplasia type 1 (MEN1) is defined as the occurrence of tumours in two of three main endocrine tissue types: parathyroid, pituitary and pancreaticoduodenal...
  11. Lin S, Elledge S. Multiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003;113:881-9 pubmed
    ..The third, the tumor suppressor Menin, is a direct repressor of hTERT...
  12. Guru S, Goldsmith P, Burns A, Marx S, Spiegel A, Collins F, et al. Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci U S A. 1998;95:1630-4 pubmed
    ..in which are responsible for multiple endocrine neoplasia type 1 (MEN1), encodes a 610-amino acid protein, denoted menin. The amino acid sequence of this putative tumor suppressor offers no clue to the function or subcellular location ..
  13. Hannan F, Nesbit M, Christie P, Fratter C, Dudley N, Sadler G, et al. Familial isolated primary hyperparathyroidism caused by mutations of the MEN1 gene. Nat Clin Pract Endocrinol Metab. 2008;4:53-8 pubmed
    ..an autosomal dominant disorder that can represent an early stage of either the multiple endocrine neoplasia type 1 (MEN1) or hyperparathyroidism-jaw tumor (HPT-JT) syndromes; alternatively, the condition can be caused by an allelic ..
  14. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero D, Kitabayashi I, et al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004;24:5639-49 pubmed
    ..b>Menin, a product of the MEN1 tumor suppressor gene, is also a component of the 1-MDa MLL complex...
  15. Huang J, Gurung B, Wan B, Matkar S, Veniaminova N, Wan K, et al. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 2012;482:542-6 pubmed publisher
    b>Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is characterized by tumorigenesis in multiple endocrine organs...
  16. Suphapeetiporn K, Greally J, Walpita D, Ashley T, Bale A. MEN1 tumor-suppressor protein localizes to telomeres during meiosis. Genes Chromosomes Cancer. 2002;35:81-5 pubmed
    ..The gene encodes a nuclear protein, menin, with no recognized functional motifs...
  17. Villablanca A, Wassif W, Smith T, Höög A, Vierimaa O, Kassem M, et al. Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism. Eur J Endocrinol. 2002;147:313-22 pubmed
    ..The entire MEN1 gene was sequenced for germline mutations and, in addition, tumour specimens were analysed in comparative genomic ..
  18. Jin S, Mao H, Schnepp R, Sykes S, Silva A, D Andrea A, et al. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 2003;63:4204-10 pubmed
    ..The gene mutated in MEN1 patients, Men1, encodes a protein of 610 amino acid residues, menin, and mutations in the Men1 gene lead to the MEN1 syndrome...
  19. Scacheri P, Davis S, Odom D, Crawford G, Perkins S, Halawi M, et al. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet. 2006;2:e51 pubmed
    ..The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase ..
  20. Yan J, Yang Y, Zhang H, King C, Kan H, Cai Y, et al. Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells. Oncogene. 2009;28:973-82 pubmed publisher
    ..is a dominantly inherited tumor syndrome that results from the mutation of the MEN1 gene that encodes protein menin. Stable overexpression of MEN1 has been shown to partially suppress the Ras-mediated morphological changes of ..
  21. Lemmens I, Forsberg L, Pannett A, Meyen E, Piehl F, Turner J, et al. Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun. 2001;286:426-31 pubmed
    The tumour suppressor gene causing multiple endocrine neoplasia type 1 (MEN1) encodes a 610 amino acid protein, menin. In order to identify menin-interacting proteins we used a yeast two-hybrid assay to screen a 12...
  22. Schnepp R, Hou Z, Wang H, Petersen C, Silva A, Masai H, et al. Functional interaction between tumor suppressor menin and activator of S-phase kinase. Cancer Res. 2004;64:6791-6 pubmed
    ..The gene mutated in MEN1 patients, Men1, encodes a tumor suppressor, menin. Overexpression of menin leads to inhibition of Ras-transformed cells...
  23. Wautot V, Khodaei S, Frappart L, Buisson N, Baro E, Lenoir G, et al. Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues. Int J Cancer. 2000;85:877-81 pubmed
    We have investigated the endogenous expression of menin, a protein encoded by the gene mutated in multiple endocrine neoplasia type 1 (MEN1)...
  24. Olufemi S, Green J, Manickam P, Guru S, Agarwal S, Kester M, et al. Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. Hum Mutat. 1998;11:264-9 pubmed
    Familial multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder with affected individuals developing parathyroid, gastrointestinal (GI) endocrine, and anterior pituitary tumors...
  25. Milne T, Hughes C, Lloyd R, Yang Z, Rozenblatt Rosen O, Dou Y, et al. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A. 2005;102:749-54 pubmed
    ..The mechanism by which MEN1 acts as a tumor suppressor is unclear. We have recently shown that menin, the MEN1 protein product, interacts with mixed lineage leukemia (MLL) family proteins in a histone ..
  26. Jiao Y, Shi C, Edil B, de Wilde R, Klimstra D, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199-203 pubmed publisher
    ..implicated in chromatin remodeling: 44% of the tumors had somatic inactivating mutations in MEN1, which encodes menin, a component of a histone methyltransferase complex, and 43% had mutations in genes encoding either of the two ..
  27. Lopez Egido J, Cunningham J, Berg M, Oberg K, Bongcam Rudloff E, Gobl A. Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity. Exp Cell Res. 2002;278:175-83 pubmed
    ..Its protein product, called menin, has been shown to associate with the AP1 transcription factor JunD and to repress JunD-mediated transcription...
  28. Farley S, Chen G, Guo S, Wang M, A J, Lee F, et al. Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage. J Surg Res. 2006;133:29-37 pubmed
    b>Menin is the tumor suppressor protein product of the gene identified in MEN1 syndrome. Evidence suggests menin binds DNA and interacts with proteins implicated in DNA damage pathways...
  29. Jiang X, Lu J, Cui B, Zhao Y, Wang W, Liu J, et al. MEN1 mutation analysis in Chinese patients with multiple endocrine neoplasia type 1. Endocr Relat Cancer. 2007;14:1073-9 pubmed
    ..sequencing showed that mutant MEN1 transcripts remained in the MEN1-associated endocrine tumours, whereas normal menin proteins could not be detected in those tumours by either immunohistochemistry or immunoblotting...
  30. Hasani Ranjbar S, Amoli M, Ebrahim Habibi A, Gozashti M, Khalili N, Sayyahpour F, et al. A new frameshift MEN1 gene mutation associated with familial malignant insulinomas. Fam Cancer. 2011;10:343-8 pubmed publisher
    ..Genetic analysis for MEN1 gene was carried out in all family members using PCR amplification of coding regions followed by direct sequencing...
  31. Matkar S, Thiel A, Hua X. Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci. 2013;38:394-402 pubmed publisher
    The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome...
  32. Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol. 2004;24:6569-80 pubmed
    ..is responsible for multiple endocrine neoplasia type 1 (MEN1) and that encodes a 610-amino-acid protein, called menin. While the majority of germ line mutations identified in MEN1 patients are frameshift and nonsense mutations ..
  33. Wautot V, Vercherat C, Lespinasse J, Chambe B, Lenoir G, Zhang C, et al. Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. Hum Mutat. 2002;20:35-47 pubmed
    ..The MEN1 gene encodes menin, a nuclear protein interacting with JunD/AP1, Smad3, NFkappaB, and other proteins involved in transcription and ..
  34. Kong C, Ellard S, Johnston C, Farid N. Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 mutation. J Endocrinol Invest. 2001;24:806-10 pubmed
    ..Thus, similar to the classic syndrome, MEN 1Burin phenotype shows poor correlation to MEN 1 genotype. ..
  35. Debelenko L, Brambilla E, Agarwal S, Swalwell J, Kester M, Lubensky I, et al. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Mol Genet. 1997;6:2285-90 pubmed
    ..Each mutation predicts truncation or potentially complete loss of menin. The remaining seven tumors showed neither the presence of a MEN1 gene mutation nor 11q13 LOH...
  36. Lourenco D, Toledo R, Mackowiak I, Coutinho F, Cavalcanti M, Correia Deur J, et al. Multiple endocrine neoplasia type 1 in Brazil: MEN1 founding mutation, clinical features, and bone mineral density profile. Eur J Endocrinol. 2008;159:259-74 pubmed publisher
    Only few large families with multiple endocrine neoplasia type 1 (MEN1) have been documented. Here, we aimed to investigate the clinical features of a seven-generation Brazilian pedigree, which included 715 at-risk family members.
  37. Corbo V, Dalai I, Scardoni M, Barbi S, Beghelli S, Bersani S, et al. MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. Endocr Relat Cancer. 2010;17:771-83 pubmed publisher
    ..ascertained genetic anomaly described in PETs, no data exist on the cellular localization of MEN1-encoded protein, menin, in normal pancreas and PETs...
  38. Ohkura N, Kishi M, Tsukada T, Yamaguchi K. Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Biochem Biophys Res Commun. 2001;282:1206-10 pubmed
    ..responsible for multiple endocrine neoplasia type 1 (MEN1) has been identified, the function of its gene product, menin, is unknown...
  39. Yokoyama A, Cleary M. Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell. 2008;14:36-46 pubmed publisher
    b>Menin displays the unique ability to either promote oncogenic function in the hematopoietic lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular mechanism of action has not been defined...
  40. Kaji H, Canaff L, Lebrun J, Goltzman D, Hendy G. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc Natl Acad Sci U S A. 2001;98:3837-42 pubmed
    ..The MEN1 gene encodes a nuclear protein called menin. In MEN1 carriers inactivating mutations give rise to a truncated product consistent with menin acting as a tumor ..
  41. Bai F, Pei X, Nishikawa T, Smith M, Xiong Y. p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. Mol Cell Biol. 2007;27:1495-504 pubmed
    ..To determine how p18 and p27 genetically interact with Men1, the tumor suppressor gene mutated in familial MEN1, we characterized p18-Men1 and p27-Men1 double mutant mice...
  42. Busygina V, Kottemann M, Scott K, Plon S, Bale A. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. Cancer Res. 2006;66:8397-403 pubmed
    ..Investigations of the biochemical function of the MEN1 protein, menin, have suggested a role as a transcriptional comodulator...
  43. Hughes C, Rozenblatt Rosen O, Milne T, Copeland T, Levine S, Lee J, et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004;13:587-97 pubmed
    The cellular function of the menin tumor suppressor protein, product of the MEN1 gene mutated in familial multiple endocrine neoplasia type 1, has not been defined...
  44. Teh B, Esapa C, Houlston R, Grandell U, Farnebo F, Nordenskjold M, et al. A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors. Am J Hum Genet. 1998;63:1544-9 pubmed
  45. MacConaill L, Hughes C, Rozenblatt Rosen O, Nannepaga S, Meyerson M. Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Mol Cancer Res. 2006;4:793-801 pubmed
    ..MEN-1 is attributable to mutations in the MEN1 tumor-suppressor gene that encodes the menin protein...
  46. Obungu V, Lee Burns A, Agarwal S, Chandrasekharapa S, Adelstein R, Marx S. Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. Oncogene. 2003;22:6347-58 pubmed
    MEN1 is a likely tumor suppressor gene that encodes a novel protein, menin. Menin is a 610 amino-acid residue protein with as yet unknown function(s)...
  47. Carrasco C, Gonzalez A, Carvajal C, Campusano C, Oestreicher E, Arteaga E, et al. Novel intronic mutation of MEN1 gene causing familial isolated primary hyperparathyroidism. J Clin Endocrinol Metab. 2004;89:4124-9 pubmed
    ..may occur as part of hereditary syndromes, including multiple endocrine neoplasia types 1 and 2A (MEN1 and MEN2A), hyperparathyroidism-jaw tumor syndrome, and the familial isolated hyperparathyroidism (FIHP)...
  48. Dreijerink K, Mulder K, Winkler G, Höppener J, Lips C, Timmers H. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res. 2006;66:4929-35 pubmed
    The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4)...
  49. Gao S, Feng Z, Xu B, Wu Y, Yin P, Yang Y, et al. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 2009;28:4095-104 pubmed publisher
    b>Menin upregulates transcription of cell-cycle inhibitors to suppress endocrine tumors, but it is poorly understood how menin suppresses non-endocrine tumors such as lung cancer...
  50. Brès V, Yoshida T, Pickle L, Jones K. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. Mol Cell. 2009;36:75-87 pubmed publisher
    ..We show here that SKIP also associates with c-Myc and Menin, a subunit of the MLL1 histone methyltransferase (H3K4me3) complex and that HIV-1 Tat transactivation requires c-..
  51. Heppner C, Bilimoria K, Agarwal S, Kester M, Whitty L, Guru S, et al. The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene. 2001;20:4917-25 pubmed
    ..The MEN1 tumor suppressor gene encodes menin, a 610 amino acid nuclear protein without sequence homology to other proteins...
  52. Gobl A, Berg M, Lopez Egido J, Oberg K, Skogseid B, Westin G. Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. Biochim Biophys Acta. 1999;1447:51-6 pubmed
    ..MEN-1 encodes a nuclear protein, called menin, of hitherto unknown function...
  53. Oberg K. The genetics of neuroendocrine tumors. Semin Oncol. 2013;40:37-44 pubmed publisher
    ..Genome-wide screening of different types of NETs can now be performed for a reasonable price and is likely to generate new insights into the tumor biology and carcinogenesis in various subtypes of NETs. ..
  54. Nakata Y, Brignier A, Jin S, Shen Y, Rudnick S, Sugita M, et al. c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood. 2010;116:1280-90 pubmed publisher
    ..Immunoprecipitation revealed that the c-Myb/GATA-3 complex contained Menin and mixed lineage leukemia (MLL)...
  55. Gracanin A, Dreijerink K, van der Luijt R, Lips C, Höppener J. Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis. Cancer Res. 2009;69:6371-4 pubmed publisher
    ..cannot be explained solely by the expression pattern of the predisposing gene MEN1 and its encoded protein, menin. This review addresses putative factors determining MEN1-associated tissue-selective tumorigenesis...