Genomes and Genes
Gene Symbol: megalin
Description: low density lipoprotein receptor-related protein 2
Alias: DBS, GP330, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, low-density lipoprotein receptor-related protein 2, megalin
Publications194 found, 100 shown here
- A megalin polymorphism associated with promoter activity and Alzheimer's disease riskTeo Vargas
Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010..This observation suggests that many, perhaps most, cases of AD are caused by faulty clearance of Abeta. Megalin, which plays an important role in mediating Abeta clearance, is an attractive candidate gene for genetic ..
- A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese populationLi ling Wang
Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Clin Chim Acta 412:268-70. 2011LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD)...
- The unfolding story of megalin (gp330): now recognized as a drug receptorM G Farquhar
J Clin Invest 96:1184. 1995
- Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptideS M Hammad
Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
J Biol Chem 272:18644-9. 1997..We have previously demonstrated that the endocytic receptor low density lipoprotein receptor-related protein-2/megalin (LRP-2), which is expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and ..
- Defective forebrain development in mice lacking gp330/megalinT E Willnow
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
Proc Natl Acad Sci U S A 93:8460-4. 1996gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
- Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptorR Raychowdhury
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Science 244:1163-5. 1989..of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced...
- Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling propertiesG Hjälm
Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
Eur J Biochem 239:132-7. 1996We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
- gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complexS Stefansson
Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Cell Sci 108:2361-8. 1995b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
- The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330M Z Kounnas
Holland Laboratory, American Red Cross, Rockville, Maryland 20855
J Biol Chem 267:21162-6. 1992..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
- Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritisS P Makker
Department of Pediatrics, University of California, Davis 95616
J Immunol 151:6500-8. 1993Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
- Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)Claudius Luziga
Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
J Mol Histol 38:65-77. 2007b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
- Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriersB V Zlokovic
Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
Proc Natl Acad Sci U S A 93:4229-34. 1996..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
- Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cordGrzegorz Wicher
Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
J Comp Neurol 492:123-31. 2005The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
- Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexusJ T Chun
Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
Exp Neurol 157:194-201. 1999Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
- Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cellsM Lundstrom
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
Am J Pathol 143:1423-35. 1993..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
- Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptorOlav A Gressner
Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
Clin Chim Acta 390:28-37. 2008....
- Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centersMichael S Okun
Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Arch Neurol 62:1250-5. 2005Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
- Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ERD Biemesderfer
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
Am J Physiol 264:F1011-20. 1993The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
- Human cytomegalovirus: detection of congenital and perinatal infection in ArgentinaAngélica Lidia Distéfano
Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
BMC Pediatr 4:11. 2004..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
- Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complexR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
Proc Natl Acad Sci U S A 90:4082-6. 1993b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
- Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated proteinR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
J Am Soc Nephrol 6:61-7. 1995The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
- Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubuleS Le Panse
Department of Cell Biology, University of Aarhus, Denmark
Exp Nephrol 5:375-83. 1997..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
- Dental fear and pain: effect on patient's perception of the dentistK H Kunzelmann
Polyclinic for Dental Care and Parodontology, Erlangen, FRG
Community Dent Oral Epidemiol 18:264-6. 1990A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
- Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domainsMaria Paz Marzolo
Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Traffic 4:273-88. 2003b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
- Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cellsM L Elkjaer
Department of Cell Biology, University of Aarhus, Denmark
Eur J Cell Biol 67:57-72. 1995..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
- Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremorJan Herzog
Department of Neurology, Christian Albrechts University Kiel, Germany
Brain 130:1608-25. 2007Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
- [Deep brain stimulation for treatment of dystonia and tremor]L Timmermann
Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
Nervenarzt 81:680-7. 2010Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
- Induction of Heymann nephritis with a gp330/megalin fusion proteinR Raychowdhury
Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
Am J Pathol 148:1613-23. 1996..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
- Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scansWieslaw L Nowinski
Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
J Neurosurg 113:1234-41. 2010The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
- Deep brain stimulation for dystonia in adults. Overview and developmentsJoachim K Krauss
Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
Stereotact Funct Neurosurg 78:168-82. 2002..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
- Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acidAndré Bento-Abreu
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
J Neurochem 111:49-60. 2009..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
- Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cellsMichael Gekle
Physiologisches Institut, Wurzburg, Germany
J Physiol 552:471-81. 2003..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
- Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionSuresh B Boppana
UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
JAMA 303:1375-82. 2010..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
- Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditisM Marino
Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
J Clin Endocrinol Metab 84:2468-74. 1999b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
- Deep brain stimulation between 1947 and 1987: the untold storyMarwan I Hariz
Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
Neurosurg Focus 29:E1. 2010Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
- Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremorTakashi Morishita
Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
J Neurosurg 112:491-6. 2010..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
- Deep brain stimulation for camptocormia in dystonia and Parkinson's diseaseHans Holger Capelle
Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
J Neurol 258:96-103. 2011..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
- Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson diseaseAntonella Peppe
Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
J Neurosurg 101:195-200. 2004The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
- Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principleYoung Min Shon
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neurosurg 112:539-48. 2010..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
- [Deep brain stimulation for Parkinson's disease and dystonia]Fusako Yokochi
Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
Brain Nerve 61:473-83. 2009Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
- Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritisAlfonso Tramontano
Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
J Immunol 172:2367-73. 2004..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
- Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsyAngelo Franzini
Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
Stereotact Funct Neurosurg 86:373-81. 2008..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
- Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobicsR Moore
Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
Community Dent Oral Epidemiol 19:347-51. 1991..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
- Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodesRichard A Wennberg
Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
Clin Neurophysiol 114:1403-18. 2003To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
- Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silicaAntonio R Cestari
Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
J Colloid Interface Sci 309:402-11. 2007..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
- Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330J J Kanalas
Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
Arch Biochem Biophys 299:255-60. 1992Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
- Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic reviewShaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
BMC Res Notes 3:60. 2010..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
- The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditionsE Coley
Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
Br J Neurosurg 23:179-83. 2009Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
- Deep brain stimulation for secondary dystonia: results in 8 patientsP F Katsakiori
Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
Acta Neurochir (Wien) 151:473-8; discussion 478. 2009..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
- Interactions between deep brain stimulation and levodopa in Parkinson's diseaseJ G Nutt
Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
Neurology 57:1835-42. 2001To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
- Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trialMichael S Okun
Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
Ann Neurol 65:586-95. 2009Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
- Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programmingMichael S Okun
Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
J Neurol Neurosurg Psychiatry 78:310-4. 2007Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
- Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targetingClement Hamani
Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
J Neurosurg 111:1209-15. 2009Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
- Thalamic deep brain stimulation: comparison between unilateral and bilateral placementW Ondo
Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
Arch Neurol 58:218-22. 2001Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
- Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian ratsHisanao Akita
Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
Brain Res 1306:159-67. 2010..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
- Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiationRaghunatha R Yammani
Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
- Long-term effects of pallidal deep brain stimulation in tardive dystoniaD Gruber
Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
Neurology 73:53-8. 2009..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
- A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
- A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohortHoutan A Taba
Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
J Neurosurg 113:1224-9. 2010In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
- Anticonvulsant serotonergic and deep brain stimulation in anterior thalamusMarek A Mirski
Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
Seizure 18:64-70. 2009..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
- Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experienceMicheal D Phillips
Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
Radiology 239:209-16. 2006..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
- Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleusLaura B Zahodne
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
J Neurol 256:1321-9. 2009While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
- Field Evaluation of Dried Blood Spots for Routine HIV-1 Viral Load and Drug Resistance Monitoring in Patients Receiving Antiretroviral Therapy in Africa and AsiaMarjorie Monleau
UMI 233 TransVIHMI, IRD, and Université de Montpellier 1, Montpellier, France
J Clin Microbiol 52:578-86. 2014Dried blood spots (DBS) can be used in developing countries to alleviate the logistic constraints of using blood plasma specimens for viral load (VL) and HIV drug resistance (HIVDR) testing, but they should be assessed under field ..
- Disparities in access to deep brain stimulation surgery for Parkinson disease: interaction between African American race and Medicaid useAndrew K Chan
Department of Neurological Surgery, Columbia University Medical Center, New York, New York
JAMA Neurol 71:291-9. 2014..To improve health care in this patient population, it is important to recognize and study the potential factors limiting access to care...
- Psychiatric side-effects of bilateral deep brain stimulation for movement disordersMarcus Pinsker
Division of Stereotactic and Functional Neurosurgery, Department of General Neurosurgery, Neurosurgical Clinic, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, D 79106, Germany
Acta Neurochir Suppl 117:47-51. 2013The effects of deep brain stimulation (DBS) on cognitive functions, and its psychiatric side-effects, are still controversial...
- Deep brain stimulation in children and young adults with secondary dystonia: the Children's Hospital Los Angeles experienceJoffre E Olaya
Division of Neurosurgery and
Neurosurg Focus 35:E7. 2013..Deep brain stimulation (DBS), specifically of the globus pallidus interna (GPi), has been shown to be extremely effective in primary ..
- Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lockChao Xu
Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Sci Signal 5:ra39. 2012Ankyrin repeat family A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone deacetylases HDAC4 and HDAC5...
- Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recoveryRemco A Koster
University of Groningen, University Medical Center Groningen, Department of Hospital and Clinical Pharmacy, Laboratory for Clinical and Forensic Toxicology and Drugs Analysis, P O Box 30 001, 9700 RB Groningen, University of Groningen, The Netherlands Electronic address
Talanta 115:47-54. 2013We developed a method for the analysis of four immunosuppressants in dried blood spot (DBS) samples to facilitate therapeutic drug monitoring for transplant patients outside the hospital...
- [Parkinson disease: deep cerebral stimulation]P Krack
Departement des Neurosciences Cliniques et Biologiques, Centre Hospitalier Universitaire, INSERM U 318, Universite Joseph Fourier, Grenoble, France
Rev Neurol (Paris) 158:S135-41. 2002The effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal pallidum (GPi) on the parkinsonian triad and on levodopa-induced dyskinesias are very similar...
- Neuropsychiatric deep brain stimulation for translational neuroimagingAnna Höflich
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
Neuroimage 79:30-41. 2013From a neuroimaging point of view, deep brain stimulation (DBS) in psychiatric disorders represents a unique source of information to probe results gained in functional, structural and molecular neuroimaging studies in vivo...
- Neurophysiology of deep brain stimulationManuela Rosa
Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
Int Rev Neurobiol 107:23-55. 2012We review the data concerning the neurophysiology of deep brain stimulation (DBS) in humans, especially in reference to Parkinson's disease...
- [The indication of DBS in Parkinosn's disease (from a neurosurgical standpoint)]Chikashi Fukaya
Division of Applied System Neuroscience, Department of Neurological Surgery, Nihon University School of Medicine
Rinsho Shinkeigaku 52:1095-7. 2012It is obvious that deep brain stimulation (DBS) is one of the useful treatment choices for progressive Parkinson disease (PD)...
- Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling taskLily R Aleksandrova
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
Behav Brain Res 245:76-82. 2013Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a treatment option for the motor symptoms of Parkinson's disease (PD). However, several recent studies have found an association between STN-DBS and increased impulsivity...
- Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasetsIuliana Ionita-Laza
Department of Biostatistics, Columbia University, New York, NY 10032, USA
Am J Hum Genet 90:1002-13. 2012....
- Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortexAnne L Spieles-Engemann
Department of Neurology, University of Cincinnati, OH, USA
J Parkinsons Dis 1:123-36. 2011The mechanisms underlying the effects of long-term deep brain stimulation of the subthalamic nucleus (STN DBS) as a therapy for Parkinson's disease (PD) remain poorly understood...
- Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activationI P Whitehead
Department of Microbiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
Mol Cell Biol 19:7759-70. 1999b>Dbs was identified initially as a transforming protein and is a member of the Dbl family of proteins (>20 mammalian members)...
- Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese populationNobuyuki Hamajima
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
Gene 503:131-6. 2012..Since the low density lipoprotein-related protein 2 (megalin) encoded by LRP2 is a multi-ligand endocytic receptor expressed in many tissues including the kidney proximal ..
- Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtrationTina Storm
Department of Biomedicine, Universityof Aarhus, Aarhus, Denmark
Nephrol Dial Transplant 28:585-91. 2013..Studies of megalin-deficient mice suggest that the large multi-ligand endocytic receptor megalin plays an essential role in this ..
- Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the ratGeoffrey Van der Plasse
Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e33455. 2012Following the successful application of deep brain stimulation (DBS) in the treatment of Parkinson's disease and promising results in clinical trials for obsessive compulsive disorder and major depression, DBS is currently being tested ..
- Speed effects of deep brain stimulation for Parkinson's diseaseFabian Klostermann
Department of Neurology, CBF, Charite University Medicine Berlin, Berlin, Germany
Mov Disord 25:2762-8. 2010Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made...
- Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's diseasePietro Caliandro
Department of Neuroscience, Institute of Neurology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
J Neural Transm 118:1477-86. 2011In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg-DBS) on gait has been object of international debate...
- LC-MS/MS sensitivity enhancement using 2D-SCX/RPLC and its application in the assessment of pharmacokinetics of clonidine in dried blood spotsFumin Li
Covance Laboratories, Inc, Bioanalytical Chemistry, Madison, WI 53704, USA
Bioanalysis 3:1577-86. 2011Dried blood spot (DBS) technology offers distinctive preclinical and clinical advantages primarily ascribed to microscale sampling (e.g., 40-80 µl per time point), and the nature of solid-state samples in filter papers...
- Retinol-binding protein stability in dried blood spotsMasako Fujita
Department of Anthropology, University of Washington, Seattle, WA 98195 3100, USA
Clin Chem 53:1972-5. 2007..A recently developed enzyme immunoassay for RBP uses serum or whole blood stored as dried blood spots (DBS). However, the stability of RBP in DBS has not been examined.
- HIV-1 drug resistance testing from dried blood spots collected in rural Tanzania using the ViroSeq HIV-1 Genotyping SystemAsgeir Johannessen
Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway
J Antimicrob Chemother 66:260-4. 2011..HIV-1 Genotyping System (Abbott Molecular, Des Plains, IL, USA) can be used in conjunction with dried blood spots (DBS) for clinical monitoring of drug resistance in patients who fail antiretroviral treatment (ART) in rural Tanzania.
- Feasibility of neonatal dried blood spot retrieval amid evolving state policies (2009-2010): a Children's Oncology Group studyAmy M Linabery
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
Paediatr Perinat Epidemiol 25:549-58. 2011Dried blood spots (DBS) are collected uniformly from US newborns to test for metabolic and other disorders. Because evidence exists for prenatal origins of some diseases, DBS may provide unique prenatal exposure records...
- Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MSChristopher Smith
Clinical Pharmacology Department, Alderley, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Bioanalysis 3:145-56. 2011..Blood microsamples were collected in three ways, either as a dried blood spot (DBS), a blood sample collected in a micropipette placed in a plastic tube and mixed with water or as plasma in the ..
- Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalinCraig Slattery
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
Cell Physiol Biochem 27:171-8. 2011The scavenger receptor megalin binds to albumin in the microvilli of the renal proximal tubule, and transports the ligand to the intravillar cleft for processing by endocytosis...
- Deep brain stimulation in the treatment of secondary dystoniaJian Guo Zhang
Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
Chin Med J (Engl) 119:2069-74. 2006..in whom symptoms are inadequately controlled with pharmacologic measures, the use of deep brain stimulation (DBS) can improve symptoms and enhance functional capacity...
- Implantation of electrodes for deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease with the aid of intraoperative microrecording under general anesthesiaFrank Hertel
Department of Neurosurgery, Brüderkrankenhaus, Trier, Germany
Neurosurgery 59:E1138; discussion E1138. 2006Deep brain stimulation (DBS) is widely accepted in the treatment of advanced Parkinson's disease (PD) and other movement disorders. The standard implantation procedure is performed under local anesthesia (LA)...
- LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimensAndrea Faller
Institute of Legal and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany
Anal Bioanal Chem 401:1163-6. 2011..Analysis of dried blood spots (DBS) is particularly advantageous for the determination of delicate analytes such as PEth...
- An evaluation of rating scales utilized for deep brain stimulation for dystoniaFrandy Susatia
Movement Disorders Center, Department of Neurology, University of Florida, Gainesville, FL 32610, USA
J Neurol 257:44-58. 2010The objective of this study was to examine globus pallidus internus deep brain stimulation (GPi-DBS) outcomes in primary and secondary dystonia, derived from blinded ratings using two scales and two raters...
- Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidityJ Gerardo Garcia-Lerma
Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Antimicrob Chemother 64:33-6. 2009Dried blood spots (DBS) and dried plasma spots (DPS) are considered convenient alternatives to serum and plasma for HIV drug resistance testing in resource-limited settings...
- Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studiesYuanyuan Li
Advion BioServices, Inc, Ithaca, NY, USA
Bioanalysis 3:2501-14. 2011Dried blood spot (DBS) technology was evaluated for the quantitative determination of guanfacine in human blood in clinical studies...
- Determination of moxifloxacin in dried blood spots using LC-MS/MS and the impact of the hematocrit and blood volumeD H Vu
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
J Chromatogr B Analyt Technol Biomed Life Sci 879:1063-70. 2011..sampling for TDM is facing logistical challenges, especially in limited resource areas, and dried blood spots (DBS) sampling may offer a chance to overcome this problem...
- The number and nature of emergency department encounters in patients with deep brain stimulatorsAndrew S Resnick
Department of Neurology, University of Florida, Gainesville, USA
J Neurol 257:122-31. 2010Deep brain stimulation (DBS) has become an increasingly common modality for control of several neurological disorders such as Parkinson's disease, dystonia, essential tremor (ET), and others...
- A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)Oraporn Sitburana
Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
Clin Neurol Neurosurg 112:106-9. 2010To perform a pilot study to investigate the relationship between the microlesion effect (MLE) seen in deep brain stimulation (DBS) of the ventralis intermedius nucleus (VIM) and subsequent tremor response and DBS parameter settings.
- Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson's diseaseV J Khandwala
Dept Biomedical Eng, Univ Rochester, NY, USA
Conf Proc IEEE Eng Med Biol Soc 2009:1553-6. 2009Therapeutic benefits of subthalamic nucleus (STN) deep brain stimulation (DBS) for motor symptoms of Parkinson's disease (PD) are well-documented. However, the mechanisms underlying motor improvement with DBS remain poorly understood...
- Effective inhibition of substantia nigra by deep brain stimulation fails to suppress tonic epileptic seizuresSafa Shehab
Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, UAE
Neurobiol Dis 43:725-35. 2011Experimental and clinical data suggest that high-frequency deep brain stimulation (DBS) of different subcortical structures can be used to control or modulate epileptic seizures...
- Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the ratTine Wyckhuys
Laboratory for Clinical and Experimental Neurophysiology, Ghent University Hospital, Ghent, Belgium
Neuroimage 52:55-61. 2010Deep brain stimulation (DBS) is a promising experimental approach to treat various neurological disorders. However, the optimal stimulation paradigm and the precise mechanism of action of DBS are unknown...
- Assessment of DNA contamination from dried blood spots and determination of DNA yield and function using archival newborn dried blood spotsSuzanne K Cordovado
Centers for Disease Control and Prevention, Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, Georgia 30341, United States
Clin Chim Acta 402:107-13. 2009Residual dried blood spots (DBS) from newborn screening programs are often stored for years and are sometimes used for epidemiological studies...
- Dorsal Column Stimulation as a New Therapy for Motor DisordersMiguel A L Nicolelis; Fiscal Year: 2013..The electrical stimulation of subcortical areas of the brain (deep brain stimulation - DBS) is an effective alternative option, which is rather restricted due to its invasiveness and associated risks...
- Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons DiseaseJAIME A KAMINER; Fiscal Year: 2013..Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) stimulation will be applied to 6-OHDA lesioned ..
- MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PDTAMARA G HERSHEY; Fiscal Year: 2012..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
- CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loopMichelle M McCarthy; Fiscal Year: 2013..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that ..
- Deep Brain Stimulation in the Parkinsonian MonkeyJerrold L Vitek; Fiscal Year: 2012..Despite the widespread use of DBS, its mechanism of action remains unclear...
- DBS of the pedunculopontine nucleus in Parkinsonian primateJerrold L Vitek; Fiscal Year: 2010..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy ..
- Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulationROBERT STERLING TURNER; Fiscal Year: 2013..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing abnormalities in GPi ..
- Arrays for deep brain microstimulation and recordingDOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010Electrical stimulation in deep brain structures (DBS) has developed into an effective treatment for advanced Parkinson's disease and essential tremor...
- STN Stimulation: Neural Control of Movement and PostureDANIEL MONTIE CORCOS; Fiscal Year: 2011High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
- Effects of DBS on sensorimotor processesJing Yu Chang; Fiscal Year: 2005..Deep brain stimulation (DBS) of subthalamic nucleus (STN) has been used increasingly in the clinic to alleviate Parkinsonian syndromes (PS) ..
- EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROLFay Horak; Fiscal Year: 2005..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
- Scheduled and Responsive Brain Stimulation for the Treatment of Tourette SyndromeMichael S Okun; Fiscal Year: 2010..Chronic high frequency deep brain stimulation (DBS) has recently emerged as a possible therapeutic option in refractory cases incapacitated by their tics...
- Evaluation of MRI Safety for Deep Brain StimulationAli Rezai; Fiscal Year: 2004There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
- Cortical and basal ganglia local field potentials in human movement disordersPhilip A Starr; Fiscal Year: 2012..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
- Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyJerrold L Vitek; Fiscal Year: 2013..motor signs in Parkinson's disease (PD), and the improvement in motor function during deep brain stimulation (DBS)...
- MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONSMark George; Fiscal Year: 2002DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
- CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBSWENDY LOMBARDI; Fiscal Year: 2003..of cortical activation on functional MRI (fMRI), that the cognitive and motor effects of deep brain stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the frontal lobe to ..
- Deep Brain Stimulation in Parkinson's ModelsMarjorie Anderson; Fiscal Year: 2006DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
- Clinical and neurophysiological study of subthalamic brain stimulation in PDHARRISON CARROLL WALKER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies, cell transplant strategies, and the delivery of gene-delivered growth factors ..
- Local field potentials in the basal gangliaTHOMAS N WICHMANN; Fiscal Year: 2010..Studies in humans, using implanted deep brain stimulation (DBS) electrodes to record LFPs, have suggested that high-amplitude, low frequency oscillations develop in parkinsonism ..
- Mechanism of Action of Deep Brain StimulationKendall H Lee; Fiscal Year: 2012..neuroengineering and neurosurgery will help the applicant elucidate the mechanisms by which Deep Brain Stimulation (DBS) treats Parkinson's disease...
- DEEP BRAIN STIMULATION FOR PARKINSONS DISEASEJERROLD VITEK; Fiscal Year: 2005The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
- DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PDMarjan Jahanshahi; Fiscal Year: 2005DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
- DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PDRobert Turner; Fiscal Year: 2006DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's ..
- FMRI Evaluation of DBS in Parkinson's DiseaseMICHEAL PHILLIPS; Fiscal Year: 2009..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
- WI State Public Health Lab Capacity for SCID ScreeningCHARLES DENNIS BROKOPP; Fiscal Year: 2010..we performed two large-scale studies to determine the feasibility of quantitating TRECs using dried blood spots (DBS) to detect SCID newborns...
- Trafficking of LRP and Megalin in Polarized CellsGuojun Bu; Fiscal Year: 2006DESCRIPTION (provided by applicant) Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large membrane glycoproteins that belong to the LDL receptor gene family...
- SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISMEdwin Naylor; Fiscal Year: 2000..of the very cost effective and accurate method for screening newborn infants using filter paper dried blood spots (DBS) can be applied to pediatric and adult populations to detect diseases before disability and severe symptoms develop,..
- SERUM PROTEIN BINDING THE HN AUTOANTIGENJOHN KANALAS; Fiscal Year: 1993..Although a glycoprotein isolated form the brush border (gp330) is generally recognized as the putative antigen of HN, it's normal function has yet to be determined...
- Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig ModelWilliam P Melega; Fiscal Year: 2010..Known as deep brain stimulation (DBS), it has been successfully used to treat various human brain disorders (e.g...
- Ethics of Control and Consent in Brain Stimulation for Parkinson DiseaseCYNTHIA M S KUBU; Fiscal Year: 2010..the ethical challenges inherent in participants'considerations of control using Deep Brain Stimulation (DBS) for the treatment of Parkinson disease (PD) as a paradigm...
- Deep Brain Stimulation Array for NeuromodulationRIO VETTER; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
- Motor Learning in Parkinson's DiseaseM Ghilardi; Fiscal Year: 2002..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
- Advanced Technology and Tools for DBS Programming for Speech FunctionalityCraig van Horne; Fiscal Year: 2009..Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders...