megalin

Summary

Gene Symbol: megalin
Description: low density lipoprotein receptor-related protein 2
Alias: DBS, GP330, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, low-density lipoprotein receptor-related protein 2, megalin
Species: human

Top Publications

  1. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
  2. ncbi Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
  3. ncbi gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Cell Sci 108:2361-8. 1995
  4. ncbi The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    M Z Kounnas
    Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 267:21162-6. 1992
  5. ncbi Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritis
    S P Makker
    Department of Pediatrics, University of California, Davis 95616
    J Immunol 151:6500-8. 1993
  6. ncbi Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
    Claudius Luziga
    Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Mol Histol 38:65-77. 2007
  7. ncbi Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    B V Zlokovic
    Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
    Proc Natl Acad Sci U S A 93:4229-34. 1996
  8. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
  9. ncbi Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus
    J T Chun
    Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
    Exp Neurol 157:194-201. 1999
  10. ncbi Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells
    M Lundstrom
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
    Am J Pathol 143:1423-35. 1993

Research Grants

  1. DEEP BRAIN STIMULATION FOR PARKINSONS DISEASE
    JERROLD VITEK; Fiscal Year: 2005
  2. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    Tamara Hershey; Fiscal Year: 2009
  3. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2010
  4. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
  5. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
  6. Deep Brain Stimulation in the Parkinsonian Monkey
    JERROLD VITEK; Fiscal Year: 2006
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
  8. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
  9. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010
  10. FMRI Evaluation of DBS in Parkinson's Disease
    MICHEAL PHILLIPS; Fiscal Year: 2009

Detail Information

Publications175 found, 100 shown here

  1. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
    We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
  2. ncbi Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
    gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
  3. ncbi gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Cell Sci 108:2361-8. 1995
    b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
  4. ncbi The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    M Z Kounnas
    Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 267:21162-6. 1992
    ..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
  5. ncbi Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritis
    S P Makker
    Department of Pediatrics, University of California, Davis 95616
    J Immunol 151:6500-8. 1993
    Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
  6. ncbi Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
    Claudius Luziga
    Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Mol Histol 38:65-77. 2007
    b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
  7. ncbi Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    B V Zlokovic
    Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
    Proc Natl Acad Sci U S A 93:4229-34. 1996
    ..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
  8. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
    The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
  9. ncbi Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus
    J T Chun
    Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
    Exp Neurol 157:194-201. 1999
    Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
  10. ncbi Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells
    M Lundstrom
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
    Am J Pathol 143:1423-35. 1993
    ..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
  11. ncbi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
    ....
  12. ncbi Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
    Michael S Okun
    Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 62:1250-5. 2005
    Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
  13. ncbi Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER
    D Biemesderfer
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
    Am J Physiol 264:F1011-20. 1993
    The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
  14. ncbi Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
    J Am Soc Nephrol 6:61-7. 1995
    The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
  15. ncbi Human cytomegalovirus: detection of congenital and perinatal infection in Argentina
    Angélica Lidia Distéfano
    Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
    BMC Pediatr 4:11. 2004
    ..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
  16. ncbi Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 90:4082-6. 1993
    b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
  17. ncbi Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule
    S Le Panse
    Department of Cell Biology, University of Aarhus, Denmark
    Exp Nephrol 5:375-83. 1997
    ..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
  18. ncbi Dental fear and pain: effect on patient's perception of the dentist
    K H Kunzelmann
    Polyclinic for Dental Care and Parodontology, Erlangen, FRG
    Community Dent Oral Epidemiol 18:264-6. 1990
    A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
  19. ncbi Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains
    Maria Paz Marzolo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Traffic 4:273-88. 2003
    b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
  20. ncbi Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells
    M L Elkjaer
    Department of Cell Biology, University of Aarhus, Denmark
    Eur J Cell Biol 67:57-72. 1995
    ..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
  21. ncbi Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Brain 130:1608-25. 2007
    Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
  22. ncbi [Deep brain stimulation for treatment of dystonia and tremor]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
    Nervenarzt 81:680-7. 2010
    Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
  23. ncbi Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scans
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
    J Neurosurg 113:1234-41. 2010
    The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
  24. ncbi Induction of Heymann nephritis with a gp330/megalin fusion protein
    R Raychowdhury
    Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 148:1613-23. 1996
    ..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
  25. ncbi Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid
    André Bento-Abreu
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    J Neurochem 111:49-60. 2009
    ..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
  26. ncbi Deep brain stimulation for dystonia in adults. Overview and developments
    Joachim K Krauss
    Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
    Stereotact Funct Neurosurg 78:168-82. 2002
    ..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
  27. ncbi Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells
    Michael Gekle
    Physiologisches Institut, Wurzburg, Germany
    J Physiol 552:471-81. 2003
    ..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
  28. ncbi Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection
    Suresh B Boppana
    UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
    JAMA 303:1375-82. 2010
    ..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
  29. ncbi Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis
    M Marino
    Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Clin Endocrinol Metab 84:2468-74. 1999
    b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
  30. ncbi Deep brain stimulation for camptocormia in dystonia and Parkinson's disease
    Hans Holger Capelle
    Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
    J Neurol 258:96-103. 2011
    ..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
  31. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
  32. ncbi Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
  33. ncbi Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principle
    Young Min Shon
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 112:539-48. 2010
    ..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
  34. ncbi Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremor
    Takashi Morishita
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurosurg 112:491-6. 2010
    ..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
  35. ncbi Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritis
    Alfonso Tramontano
    Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 172:2367-73. 2004
    ..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
  36. ncbi [Deep brain stimulation for Parkinson's disease and dystonia]
    Fusako Yokochi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Brain Nerve 61:473-83. 2009
    Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
  37. ncbi Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsy
    Angelo Franzini
    Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Stereotact Funct Neurosurg 86:373-81. 2008
    ..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
  38. ncbi Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobics
    R Moore
    Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
    Community Dent Oral Epidemiol 19:347-51. 1991
    ..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
  39. ncbi Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes
    Richard A Wennberg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
    Clin Neurophysiol 114:1403-18. 2003
    To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
  40. ncbi Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silica
    Antonio R Cestari
    Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
    J Colloid Interface Sci 309:402-11. 2007
    ..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
  41. ncbi Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330
    J J Kanalas
    Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
    Arch Biochem Biophys 299:255-60. 1992
    Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
  42. ncbi The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditions
    E Coley
    Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Br J Neurosurg 23:179-83. 2009
    Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
  43. ncbi Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Res Notes 3:60. 2010
    ..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
  44. ncbi Deep brain stimulation for secondary dystonia: results in 8 patients
    P F Katsakiori
    Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
    Acta Neurochir (Wien) 151:473-8; discussion 478. 2009
    ..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
  45. ncbi Interactions between deep brain stimulation and levodopa in Parkinson's disease
    J G Nutt
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 57:1835-42. 2001
    To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
  46. ncbi Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  47. ncbi Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
  48. ncbi Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
    J Neurol Neurosurg Psychiatry 78:310-4. 2007
    Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
  49. ncbi A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohort
    Houtan A Taba
    Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
    J Neurosurg 113:1224-9. 2010
    In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
  50. ncbi A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
  51. ncbi Thalamic deep brain stimulation: comparison between unilateral and bilateral placement
    W Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
    Arch Neurol 58:218-22. 2001
    Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
  52. ncbi Long-term effects of pallidal deep brain stimulation in tardive dystonia
    D Gruber
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Neurology 73:53-8. 2009
    ..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
  53. ncbi Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experience
    Micheal D Phillips
    Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiology 239:209-16. 2006
    ..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
  54. ncbi Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus
    Marek A Mirski
    Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
    Seizure 18:64-70. 2009
    ..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
  55. ncbi Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation
    Raghunatha R Yammani
    Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002
    The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
  56. ncbi Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian rats
    Hisanao Akita
    Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
    Brain Res 1306:159-67. 2010
    ..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
  57. ncbi Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
  58. ncbi Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat
    Geoffrey Van der Plasse
    Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e33455. 2012
    Following the successful application of deep brain stimulation (DBS) in the treatment of Parkinson's disease and promising results in clinical trials for obsessive compulsive disorder and major depression, DBS is currently being tested ..
  59. ncbi Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)
    J R Korenberg
    Medical Genetics Birth Defects Center, Cedars Sinai Medical Center, Los Angeles, California 90048 1869
    Genomics 22:88-93. 1994
    b>Glycoprotein 330 (gp330) is a member of a family of receptors with structural similarities to the low-density lipoprotein receptor...
  60. ncbi Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson's disease
    V J Khandwala
    Dept Biomedical Eng, Univ Rochester, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:1553-6. 2009
    Therapeutic benefits of subthalamic nucleus (STN) deep brain stimulation (DBS) for motor symptoms of Parkinson's disease (PD) are well-documented. However, the mechanisms underlying motor improvement with DBS remain poorly understood...
  61. ncbi Reoperation for suboptimal outcomes after deep brain stimulation surgery
    Tina Marie Ellis
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA
    Neurosurgery 63:754-60; discussion 760-1. 2008
    To examine a case series of reoperations for deep brain stimulation (DBS) leads in which clinical scenarios revealed suboptimal outcome from a previous operation...
  62. ncbi Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family
    A Saito
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
    Proc Natl Acad Sci U S A 91:9725-9. 1994
    ..We suggest the name megalin (from Greek mega) for gp330, the largest plasma membrane protein identified so far in vertebrates...
  63. ncbi Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients
    Jay L Alberts
    Department of Biomedical Engineering, Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH 44195, USA
    Brain 131:3348-60. 2008
    Deep brain stimulation (DBS) is a surgical procedure that has been shown effective in improving the cardinal motor signs of advanced Parkinson's disease, however, declines in cognitive function have been associated with bilateral ..
  64. ncbi Assessment of DNA contamination from dried blood spots and determination of DNA yield and function using archival newborn dried blood spots
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, Georgia 30341, United States
    Clin Chim Acta 402:107-13. 2009
    Residual dried blood spots (DBS) from newborn screening programs are often stored for years and are sometimes used for epidemiological studies...
  65. ncbi Neural correlates of STN DBS-induced cognitive variability in Parkinson disease
    M C Campbell
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States
    Neuropsychologia 46:3162-9. 2008
    Although deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance...
  66. ncbi [Three-dimensional atlas of subthalamic nucleus and its adjacent structures]
    Naoki Nakano
    Department of Neurosurgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    No Shinkei Geka 33:683-92. 2005
    The deep brain stimulation (DBS) is an effective treatment modality of the functional neurosurgery for disorders such as Parkinson's disease, essential tremor and generalized dystonia...
  67. ncbi Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide
    Marion de Jong
    Department of Nuclear Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    J Nucl Med 46:1696-700. 2005
    ..A possible receptor candidate is megalin, a multiligand scavenger receptor in the renal proximal tubules...
  68. ncbi Deep brain stimulation of the subthalamic nucleus affects resting EEG and visual evoked potentials in Parkinson's disease
    Robert Jech
    Department of Neurology, 1st Medical Faculty, Charles University, Katerinska 30, 120 00 Prague 2, Czech Republic
    Clin Neurophysiol 117:1017-28. 2006
    We studied changes of the EEG spectral power induced by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD)...
  69. ncbi Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, and European Graduate School of Neuroscience, Maastricht, The Netherlands
    Neurosurgery 61:346-55; discussion 355-7. 2007
    ..electrophysiological techniques contribute to the outcome of subthalamic nucleus (STN) deep brain stimulation (DBS)...
  70. ncbi Implantation of electrodes for deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease with the aid of intraoperative microrecording under general anesthesia
    Frank Hertel
    Department of Neurosurgery, Brüderkrankenhaus, Trier, Germany
    Neurosurgery 59:E1138; discussion E1138. 2006
    Deep brain stimulation (DBS) is widely accepted in the treatment of advanced Parkinson's disease (PD) and other movement disorders. The standard implantation procedure is performed under local anesthesia (LA)...
  71. ncbi Deep brain stimulation in the treatment of secondary dystonia
    Jian Guo Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
    Chin Med J (Engl) 119:2069-74. 2006
    ..in whom symptoms are inadequately controlled with pharmacologic measures, the use of deep brain stimulation (DBS) can improve symptoms and enhance functional capacity...
  72. ncbi Specific effect of maleate on an apical membrane glycoprotein (gp330) in proximal tubule of rat kidneys
    M Bergeron
    Department of Physiology, Universite de Montreal, Quebec, Canada
    Am J Physiol 271:F908-16. 1996
    ..Because the apical membrane glycoprotein, gp330, is a receptor associated with the apical endocytotic and recycling apparatus in these cells, we examined the ..
  73. ncbi Retinol-binding protein stability in dried blood spots
    Masako Fujita
    Department of Anthropology, University of Washington, Seattle, WA 98195 3100, USA
    Clin Chem 53:1972-5. 2007
    ..A recently developed enzyme immunoassay for RBP uses serum or whole blood stored as dried blood spots (DBS). However, the stability of RBP in DBS has not been examined.
  74. ncbi A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily
    S Lundgren
    Uppsala Genetic Center, Department of Cell Research, Swedish University of Agricultural Sciences
    Exp Cell Res 212:344-50. 1994
    ..It is proposed that the currently identified protein constitutes part of a common structure for the sensing of extracellular calcium concentrations and influences calcium homeostasis in different organs...
  75. ncbi Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's disease
    L Rossi
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
    Brain Res Bull 76:512-21. 2008
    How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear...
  76. ncbi Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter
    Masayo Yamagata
    Department of Environmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
    J Am Soc Nephrol 16:2338-45. 2005
    b>Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins...
  77. ncbi Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidity
    J Gerardo Garcia-Lerma
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Antimicrob Chemother 64:33-6. 2009
    Dried blood spots (DBS) and dried plasma spots (DPS) are considered convenient alternatives to serum and plasma for HIV drug resistance testing in resource-limited settings...
  78. ncbi Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MS
    Christopher Smith
    Clinical Pharmacology Department, Alderley, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    Bioanalysis 3:145-56. 2011
    ..Blood microsamples were collected in three ways, either as a dried blood spot (DBS), a blood sample collected in a micropipette placed in a plastic tube and mixed with water or as plasma in the ..
  79. ncbi Deep brain stimulation of the subthalamic nucleus improves temperature sensation in patients with Parkinson's disease
    Tomoyuki Maruo
    Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Pain 152:860-5. 2011
    ..However, little is known about the effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on temperature sensation as measured by quantitative sensory testing (QST)...
  80. ncbi Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin
    Craig Slattery
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Cell Physiol Biochem 27:171-8. 2011
    The scavenger receptor megalin binds to albumin in the microvilli of the renal proximal tubule, and transports the ligand to the intravillar cleft for processing by endocytosis...
  81. ncbi Determination of moxifloxacin in dried blood spots using LC-MS/MS and the impact of the hematocrit and blood volume
    D H Vu
    Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1063-70. 2011
    ..sampling for TDM is facing logistical challenges, especially in limited resource areas, and dried blood spots (DBS) sampling may offer a chance to overcome this problem...
  82. ncbi LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimens
    Andrea Faller
    Institute of Legal and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Anal Bioanal Chem 401:1163-6. 2011
    ..Analysis of dried blood spots (DBS) is particularly advantageous for the determination of delicate analytes such as PEth...
  83. ncbi LC-MS/MS sensitivity enhancement using 2D-SCX/RPLC and its application in the assessment of pharmacokinetics of clonidine in dried blood spots
    Fumin Li
    Covance Laboratories, Inc, Bioanalytical Chemistry, Madison, WI 53704, USA
    Bioanalysis 3:1577-86. 2011
    Dried blood spot (DBS) technology offers distinctive preclinical and clinical advantages primarily ascribed to microscale sampling (e.g., 40-80 µl per time point), and the nature of solid-state samples in filter papers...
  84. ncbi Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's disease
    Pietro Caliandro
    Department of Neuroscience, Institute of Neurology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
    J Neural Transm 118:1477-86. 2011
    In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg-DBS) on gait has been object of international debate...
  85. ncbi Feasibility of neonatal dried blood spot retrieval amid evolving state policies (2009-2010): a Children's Oncology Group study
    Amy M Linabery
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    Paediatr Perinat Epidemiol 25:549-58. 2011
    Dried blood spots (DBS) are collected uniformly from US newborns to test for metabolic and other disorders. Because evidence exists for prenatal origins of some diseases, DBS may provide unique prenatal exposure records...
  86. ncbi Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studies
    Yuanyuan Li
    Advion BioServices, Inc, Ithaca, NY, USA
    Bioanalysis 3:2501-14. 2011
    Dried blood spot (DBS) technology was evaluated for the quantitative determination of guanfacine in human blood in clinical studies...
  87. ncbi HIV-1 drug resistance testing from dried blood spots collected in rural Tanzania using the ViroSeq HIV-1 Genotyping System
    Asgeir Johannessen
    Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway
    J Antimicrob Chemother 66:260-4. 2011
    ..HIV-1 Genotyping System (Abbott Molecular, Des Plains, IL, USA) can be used in conjunction with dried blood spots (DBS) for clinical monitoring of drug resistance in patients who fail antiretroviral treatment (ART) in rural Tanzania.
  88. ncbi Speed effects of deep brain stimulation for Parkinson's disease
    Fabian Klostermann
    Department of Neurology, CBF, Charite University Medicine Berlin, Berlin, Germany
    Mov Disord 25:2762-8. 2010
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made...
  89. ncbi Effective inhibition of substantia nigra by deep brain stimulation fails to suppress tonic epileptic seizures
    Safa Shehab
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, UAE
    Neurobiol Dis 43:725-35. 2011
    Experimental and clinical data suggest that high-frequency deep brain stimulation (DBS) of different subcortical structures can be used to control or modulate epileptic seizures...
  90. ncbi The expression of megalin (gp330) and LRP diverges during F9 cell differentiation
    R P Czekay
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
    J Cell Sci 108:1433-41. 1995
    ..a chaperonin-like molecule that binds to two members of the low density lipoprotein receptor (LDLR) superfamily-megalin (gp330) and the LDL receptor-related protein (LRP)...
  91. ncbi The number and nature of emergency department encounters in patients with deep brain stimulators
    Andrew S Resnick
    Department of Neurology, University of Florida, Gainesville, USA
    J Neurol 257:122-31. 2010
    Deep brain stimulation (DBS) has become an increasingly common modality for control of several neurological disorders such as Parkinson's disease, dystonia, essential tremor (ET), and others...
  92. ncbi A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)
    Oraporn Sitburana
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Clin Neurol Neurosurg 112:106-9. 2010
    To perform a pilot study to investigate the relationship between the microlesion effect (MLE) seen in deep brain stimulation (DBS) of the ventralis intermedius nucleus (VIM) and subsequent tremor response and DBS parameter settings.
  93. ncbi Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat
    Tine Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Ghent University Hospital, Ghent, Belgium
    Neuroimage 52:55-61. 2010
    Deep brain stimulation (DBS) is a promising experimental approach to treat various neurological disorders. However, the optimal stimulation paradigm and the precise mechanism of action of DBS are unknown...
  94. ncbi Development and application of a broadly sensitive dried-blood-spot-based genotyping assay for global surveillance of HIV-1 drug resistance
    Chunfu Yang
    Division of Global AIDS, International Laboratory Branch, DGHA, NCHHSTP, CDC, Mail Stop A 11, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Clin Microbiol 48:3158-64. 2010
    ..We have developed and applied a broadly sensitive dried-blood-spot (DBS)-based genotyping assay for surveillance of HIV-1 DR in international settings...
  95. ncbi Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 267:26172-80. 1992
    The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and gp330, two members of the low density lipoprotein receptor gene family, share a multitude of cysteine-rich repeats...
  96. ncbi Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein
    E I Christensen
    Department of Cell Biology, University of Aarhus, Denmark
    J Histochem Cytochem 40:1481-90. 1992
    b>gp330, a large glycoprotein located in renal proximal tubules, has sequence similarities with the low-density lipoprotein receptor and the alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein...
  97. ncbi An evaluation of rating scales utilized for deep brain stimulation for dystonia
    Frandy Susatia
    Movement Disorders Center, Department of Neurology, University of Florida, Gainesville, FL 32610, USA
    J Neurol 257:44-58. 2010
    The objective of this study was to examine globus pallidus internus deep brain stimulation (GPi-DBS) outcomes in primary and secondary dystonia, derived from blinded ratings using two scales and two raters...
  98. ncbi Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation
    Ernesto J Fuentes
    Department of Biochemistry and Biophysics, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:21188-96. 2003
    ..We determined previously that the PH domain of Dbs was critical for the intrinsic catalytic activity of the DH domain in vitro and for Dbs transformation in vivo...
  99. ncbi Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules
    H Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 11:191-202. 2000
    ..RAP also binds to the related 600-kD multiligand endocytic receptor megalin expressed in many absorptive epithelia including renal proximal tubule...
  100. ncbi Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release
    M Marino
    Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 275:7125-37. 2000
    ..Here we show that megalin (gp330), a Tg receptor on thyroid cells, plays a role in Tg transcytosis...

Research Grants105 found, 100 shown here

  1. DEEP BRAIN STIMULATION FOR PARKINSONS DISEASE
    JERROLD VITEK; Fiscal Year: 2005
    The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
  2. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    Tamara Hershey; Fiscal Year: 2009
    ..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
  3. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2010
    ..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
  4. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  5. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
  6. Deep Brain Stimulation in the Parkinsonian Monkey
    JERROLD VITEK; Fiscal Year: 2006
    ..parkinsonism and other movement disorders has been revolutionized by the introduction of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) as a highly effective treatment ..
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, the mechanisms by which HF-DBS exerts its ..
  8. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus inturnus (GPi) represent established therapies for medically refractory Parkinson's disease (PD)...
  9. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus inturnus (GPi) represent established therapies for medically refractory Parkinson's disease (PD)...
  10. FMRI Evaluation of DBS in Parkinson's Disease
    MICHEAL PHILLIPS; Fiscal Year: 2009
    ..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
  11. DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PD
    Robert Turner; Fiscal Year: 2006
    Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's disease (PD)...
  12. FMRI Evaluation of DBS in Parkinson's Disease
    MICHEAL PHILLIPS; Fiscal Year: 2007
    ..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
  13. Evaluation of MRI Safety for Deep Brain Stimulation
    Ali Rezai; Fiscal Year: 2004
    There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
  14. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2010
    ..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
  15. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..The CM/PF complex is increasingly targeted for neurosurgical interventions, such as deep brain stimulation (DBS), in the treatment of conditions such as Tourette syndrome, Parkinson's disease and others...
  16. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2010
    ..Despite the widespread use of DBS, its mechanism of action remains unclear...
  17. Deep Brain Stimulation in the Parkinsonian Monkey
    JERROLD VITEK; Fiscal Year: 2009
    ..Despite the widespread use of DBS, its mechanism of action remains unclear...
  18. Deep Brain Microelectrode Array For Functional Neurosurgery
    JAMILLE HETKE; Fiscal Year: 2007
    Deep brain stimulation (DBS) devices - 'brain pacemakers' - have recently emerged as an exciting novel neurotechnology for treating severe movement disorders, such as Parkinson's Disease and Essential Tremor...
  19. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
  20. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
  21. DEEP BRAIN STIMULATION IN PARKINSONISM
    JERROLD VITEK; Fiscal Year: 2001
    The aim of this study is to assess the effect of deep brain stimulation (DBS) within different nodal portions of the basal ganglia-thalamocortical circuit, i.e...
  22. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2004
    ..Deep brain stimulation (DBS) is proving to be a surprisingly effective approach for the control of movement disorders associated with diseases ..