Genomes and Genes
Gene Symbol: megalin
Description: low density lipoprotein receptor-related protein 2
Alias: DBS, GP330, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, low-density lipoprotein receptor-related protein 2, megalin
Publications175 found, 100 shown here
- Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling propertiesG Hjälm
Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
Eur J Biochem 239:132-7. 1996We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
- Defective forebrain development in mice lacking gp330/megalinT E Willnow
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
Proc Natl Acad Sci U S A 93:8460-4. 1996gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
- gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complexS Stefansson
Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Cell Sci 108:2361-8. 1995b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
- The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330M Z Kounnas
Holland Laboratory, American Red Cross, Rockville, Maryland 20855
J Biol Chem 267:21162-6. 1992..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
- Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritisS P Makker
Department of Pediatrics, University of California, Davis 95616
J Immunol 151:6500-8. 1993Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
- Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)Claudius Luziga
Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
J Mol Histol 38:65-77. 2007b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
- Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriersB V Zlokovic
Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
Proc Natl Acad Sci U S A 93:4229-34. 1996..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
- Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cordGrzegorz Wicher
Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
J Comp Neurol 492:123-31. 2005The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
- Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexusJ T Chun
Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
Exp Neurol 157:194-201. 1999Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
- Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cellsM Lundstrom
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
Am J Pathol 143:1423-35. 1993..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
- Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptorOlav A Gressner
Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
Clin Chim Acta 390:28-37. 2008....
- Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centersMichael S Okun
Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Arch Neurol 62:1250-5. 2005Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
- Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ERD Biemesderfer
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
Am J Physiol 264:F1011-20. 1993The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
- Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated proteinR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
J Am Soc Nephrol 6:61-7. 1995The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
- Human cytomegalovirus: detection of congenital and perinatal infection in ArgentinaAngélica Lidia Distéfano
Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
BMC Pediatr 4:11. 2004..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
- Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complexR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
Proc Natl Acad Sci U S A 90:4082-6. 1993b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
- Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubuleS Le Panse
Department of Cell Biology, University of Aarhus, Denmark
Exp Nephrol 5:375-83. 1997..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
- Dental fear and pain: effect on patient's perception of the dentistK H Kunzelmann
Polyclinic for Dental Care and Parodontology, Erlangen, FRG
Community Dent Oral Epidemiol 18:264-6. 1990A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
- Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domainsMaria Paz Marzolo
Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Traffic 4:273-88. 2003b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
- Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cellsM L Elkjaer
Department of Cell Biology, University of Aarhus, Denmark
Eur J Cell Biol 67:57-72. 1995..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
- Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremorJan Herzog
Department of Neurology, Christian Albrechts University Kiel, Germany
Brain 130:1608-25. 2007Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
- [Deep brain stimulation for treatment of dystonia and tremor]L Timmermann
Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
Nervenarzt 81:680-7. 2010Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
- Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scansWieslaw L Nowinski
Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
J Neurosurg 113:1234-41. 2010The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
- Induction of Heymann nephritis with a gp330/megalin fusion proteinR Raychowdhury
Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
Am J Pathol 148:1613-23. 1996..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
- Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acidAndré Bento-Abreu
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
J Neurochem 111:49-60. 2009..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
- Deep brain stimulation for dystonia in adults. Overview and developmentsJoachim K Krauss
Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
Stereotact Funct Neurosurg 78:168-82. 2002..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
- Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cellsMichael Gekle
Physiologisches Institut, Wurzburg, Germany
J Physiol 552:471-81. 2003..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
- Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionSuresh B Boppana
UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
JAMA 303:1375-82. 2010..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
- Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditisM Marino
Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
J Clin Endocrinol Metab 84:2468-74. 1999b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
- Deep brain stimulation for camptocormia in dystonia and Parkinson's diseaseHans Holger Capelle
Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
J Neurol 258:96-103. 2011..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
- Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson diseaseAntonella Peppe
Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
J Neurosurg 101:195-200. 2004The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
- Deep brain stimulation between 1947 and 1987: the untold storyMarwan I Hariz
Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
Neurosurg Focus 29:E1. 2010Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
- Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principleYoung Min Shon
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neurosurg 112:539-48. 2010..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
- Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremorTakashi Morishita
Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
J Neurosurg 112:491-6. 2010..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
- Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritisAlfonso Tramontano
Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
J Immunol 172:2367-73. 2004..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
- [Deep brain stimulation for Parkinson's disease and dystonia]Fusako Yokochi
Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
Brain Nerve 61:473-83. 2009Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
- Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsyAngelo Franzini
Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
Stereotact Funct Neurosurg 86:373-81. 2008..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
- Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobicsR Moore
Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
Community Dent Oral Epidemiol 19:347-51. 1991..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
- Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodesRichard A Wennberg
Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
Clin Neurophysiol 114:1403-18. 2003To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
- Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silicaAntonio R Cestari
Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
J Colloid Interface Sci 309:402-11. 2007..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
- Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330J J Kanalas
Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
Arch Biochem Biophys 299:255-60. 1992Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
- The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditionsE Coley
Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
Br J Neurosurg 23:179-83. 2009Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
- Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic reviewShaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
BMC Res Notes 3:60. 2010..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
- Deep brain stimulation for secondary dystonia: results in 8 patientsP F Katsakiori
Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
Acta Neurochir (Wien) 151:473-8; discussion 478. 2009..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
- Interactions between deep brain stimulation and levodopa in Parkinson's diseaseJ G Nutt
Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
Neurology 57:1835-42. 2001To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
- Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trialMichael S Okun
Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
Ann Neurol 65:586-95. 2009Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
- Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targetingClement Hamani
Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
J Neurosurg 111:1209-15. 2009Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
- Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programmingMichael S Okun
Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
J Neurol Neurosurg Psychiatry 78:310-4. 2007Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
- A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohortHoutan A Taba
Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
J Neurosurg 113:1224-9. 2010In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
- A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
- Thalamic deep brain stimulation: comparison between unilateral and bilateral placementW Ondo
Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
Arch Neurol 58:218-22. 2001Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
- Long-term effects of pallidal deep brain stimulation in tardive dystoniaD Gruber
Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
Neurology 73:53-8. 2009..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
- Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experienceMicheal D Phillips
Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
Radiology 239:209-16. 2006..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
- Anticonvulsant serotonergic and deep brain stimulation in anterior thalamusMarek A Mirski
Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
Seizure 18:64-70. 2009..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
- Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiationRaghunatha R Yammani
Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
- Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian ratsHisanao Akita
Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
Brain Res 1306:159-67. 2010..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
- Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleusLaura B Zahodne
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
J Neurol 256:1321-9. 2009While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
- Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the ratGeoffrey Van der Plasse
Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e33455. 2012Following the successful application of deep brain stimulation (DBS) in the treatment of Parkinson's disease and promising results in clinical trials for obsessive compulsive disorder and major depression, DBS is currently being tested ..
- Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)J R Korenberg
Medical Genetics Birth Defects Center, Cedars Sinai Medical Center, Los Angeles, California 90048 1869
Genomics 22:88-93. 1994b>Glycoprotein 330 (gp330) is a member of a family of receptors with structural similarities to the low-density lipoprotein receptor...
- Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson's diseaseV J Khandwala
Dept Biomedical Eng, Univ Rochester, NY, USA
Conf Proc IEEE Eng Med Biol Soc 2009:1553-6. 2009Therapeutic benefits of subthalamic nucleus (STN) deep brain stimulation (DBS) for motor symptoms of Parkinson's disease (PD) are well-documented. However, the mechanisms underlying motor improvement with DBS remain poorly understood...
- Reoperation for suboptimal outcomes after deep brain stimulation surgeryTina Marie Ellis
Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA
Neurosurgery 63:754-60; discussion 760-1. 2008To examine a case series of reoperations for deep brain stimulation (DBS) leads in which clinical scenarios revealed suboptimal outcome from a previous operation...
- Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene familyA Saito
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
Proc Natl Acad Sci U S A 91:9725-9. 1994..We suggest the name megalin (from Greek mega) for gp330, the largest plasma membrane protein identified so far in vertebrates...
- Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patientsJay L Alberts
Department of Biomedical Engineering, Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH 44195, USA
Brain 131:3348-60. 2008Deep brain stimulation (DBS) is a surgical procedure that has been shown effective in improving the cardinal motor signs of advanced Parkinson's disease, however, declines in cognitive function have been associated with bilateral ..
- Assessment of DNA contamination from dried blood spots and determination of DNA yield and function using archival newborn dried blood spotsSuzanne K Cordovado
Centers for Disease Control and Prevention, Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, Georgia 30341, United States
Clin Chim Acta 402:107-13. 2009Residual dried blood spots (DBS) from newborn screening programs are often stored for years and are sometimes used for epidemiological studies...
- Neural correlates of STN DBS-induced cognitive variability in Parkinson diseaseM C Campbell
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States
Neuropsychologia 46:3162-9. 2008Although deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance...
- [Three-dimensional atlas of subthalamic nucleus and its adjacent structures]Naoki Nakano
Department of Neurosurgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
No Shinkei Geka 33:683-92. 2005The deep brain stimulation (DBS) is an effective treatment modality of the functional neurosurgery for disorders such as Parkinson's disease, essential tremor and generalized dystonia...
- Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotideMarion de Jong
Department of Nuclear Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
J Nucl Med 46:1696-700. 2005..A possible receptor candidate is megalin, a multiligand scavenger receptor in the renal proximal tubules...
- Deep brain stimulation of the subthalamic nucleus affects resting EEG and visual evoked potentials in Parkinson's diseaseRobert Jech
Department of Neurology, 1st Medical Faculty, Charles University, Katerinska 30, 120 00 Prague 2, Czech Republic
Clin Neurophysiol 117:1017-28. 2006We studied changes of the EEG spectral power induced by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD)...
- Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's diseaseYasin Temel
Department of Neurosurgery, University Hospital Maastricht, and European Graduate School of Neuroscience, Maastricht, The Netherlands
Neurosurgery 61:346-55; discussion 355-7. 2007..electrophysiological techniques contribute to the outcome of subthalamic nucleus (STN) deep brain stimulation (DBS)...
- Implantation of electrodes for deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease with the aid of intraoperative microrecording under general anesthesiaFrank Hertel
Department of Neurosurgery, Brüderkrankenhaus, Trier, Germany
Neurosurgery 59:E1138; discussion E1138. 2006Deep brain stimulation (DBS) is widely accepted in the treatment of advanced Parkinson's disease (PD) and other movement disorders. The standard implantation procedure is performed under local anesthesia (LA)...
- Deep brain stimulation in the treatment of secondary dystoniaJian Guo Zhang
Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
Chin Med J (Engl) 119:2069-74. 2006..in whom symptoms are inadequately controlled with pharmacologic measures, the use of deep brain stimulation (DBS) can improve symptoms and enhance functional capacity...
- Specific effect of maleate on an apical membrane glycoprotein (gp330) in proximal tubule of rat kidneysM Bergeron
Department of Physiology, Universite de Montreal, Quebec, Canada
Am J Physiol 271:F908-16. 1996..Because the apical membrane glycoprotein, gp330, is a receptor associated with the apical endocytotic and recycling apparatus in these cells, we examined the ..
- Retinol-binding protein stability in dried blood spotsMasako Fujita
Department of Anthropology, University of Washington, Seattle, WA 98195 3100, USA
Clin Chem 53:1972-5. 2007..A recently developed enzyme immunoassay for RBP uses serum or whole blood stored as dried blood spots (DBS). However, the stability of RBP in DBS has not been examined.
- A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamilyS Lundgren
Uppsala Genetic Center, Department of Cell Research, Swedish University of Agricultural Sciences
Exp Cell Res 212:344-50. 1994..It is proposed that the currently identified protein constitutes part of a common structure for the sensing of extracellular calcium concentrations and influences calcium homeostasis in different organs...
- Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's diseaseL Rossi
Dipartimento di Scienze Neurologiche, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
Brain Res Bull 76:512-21. 2008How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear...
- Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporterMasayo Yamagata
Department of Environmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
J Am Soc Nephrol 16:2338-45. 2005b>Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins...
- Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidityJ Gerardo Garcia-Lerma
Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Antimicrob Chemother 64:33-6. 2009Dried blood spots (DBS) and dried plasma spots (DPS) are considered convenient alternatives to serum and plasma for HIV drug resistance testing in resource-limited settings...
- Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MSChristopher Smith
Clinical Pharmacology Department, Alderley, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Bioanalysis 3:145-56. 2011..Blood microsamples were collected in three ways, either as a dried blood spot (DBS), a blood sample collected in a micropipette placed in a plastic tube and mixed with water or as plasma in the ..
- Deep brain stimulation of the subthalamic nucleus improves temperature sensation in patients with Parkinson's diseaseTomoyuki Maruo
Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
Pain 152:860-5. 2011..However, little is known about the effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on temperature sensation as measured by quantitative sensory testing (QST)...
- Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalinCraig Slattery
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
Cell Physiol Biochem 27:171-8. 2011The scavenger receptor megalin binds to albumin in the microvilli of the renal proximal tubule, and transports the ligand to the intravillar cleft for processing by endocytosis...
- Determination of moxifloxacin in dried blood spots using LC-MS/MS and the impact of the hematocrit and blood volumeD H Vu
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
J Chromatogr B Analyt Technol Biomed Life Sci 879:1063-70. 2011..sampling for TDM is facing logistical challenges, especially in limited resource areas, and dried blood spots (DBS) sampling may offer a chance to overcome this problem...
- LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimensAndrea Faller
Institute of Legal and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany
Anal Bioanal Chem 401:1163-6. 2011..Analysis of dried blood spots (DBS) is particularly advantageous for the determination of delicate analytes such as PEth...
- LC-MS/MS sensitivity enhancement using 2D-SCX/RPLC and its application in the assessment of pharmacokinetics of clonidine in dried blood spotsFumin Li
Covance Laboratories, Inc, Bioanalytical Chemistry, Madison, WI 53704, USA
Bioanalysis 3:1577-86. 2011Dried blood spot (DBS) technology offers distinctive preclinical and clinical advantages primarily ascribed to microscale sampling (e.g., 40-80 µl per time point), and the nature of solid-state samples in filter papers...
- Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's diseasePietro Caliandro
Department of Neuroscience, Institute of Neurology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
J Neural Transm 118:1477-86. 2011In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg-DBS) on gait has been object of international debate...
- Feasibility of neonatal dried blood spot retrieval amid evolving state policies (2009-2010): a Children's Oncology Group studyAmy M Linabery
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
Paediatr Perinat Epidemiol 25:549-58. 2011Dried blood spots (DBS) are collected uniformly from US newborns to test for metabolic and other disorders. Because evidence exists for prenatal origins of some diseases, DBS may provide unique prenatal exposure records...
- Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studiesYuanyuan Li
Advion BioServices, Inc, Ithaca, NY, USA
Bioanalysis 3:2501-14. 2011Dried blood spot (DBS) technology was evaluated for the quantitative determination of guanfacine in human blood in clinical studies...
- HIV-1 drug resistance testing from dried blood spots collected in rural Tanzania using the ViroSeq HIV-1 Genotyping SystemAsgeir Johannessen
Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway
J Antimicrob Chemother 66:260-4. 2011..HIV-1 Genotyping System (Abbott Molecular, Des Plains, IL, USA) can be used in conjunction with dried blood spots (DBS) for clinical monitoring of drug resistance in patients who fail antiretroviral treatment (ART) in rural Tanzania.
- Speed effects of deep brain stimulation for Parkinson's diseaseFabian Klostermann
Department of Neurology, CBF, Charite University Medicine Berlin, Berlin, Germany
Mov Disord 25:2762-8. 2010Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made...
- Effective inhibition of substantia nigra by deep brain stimulation fails to suppress tonic epileptic seizuresSafa Shehab
Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, UAE
Neurobiol Dis 43:725-35. 2011Experimental and clinical data suggest that high-frequency deep brain stimulation (DBS) of different subcortical structures can be used to control or modulate epileptic seizures...
- The expression of megalin (gp330) and LRP diverges during F9 cell differentiationR P Czekay
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
J Cell Sci 108:1433-41. 1995..a chaperonin-like molecule that binds to two members of the low density lipoprotein receptor (LDLR) superfamily-megalin (gp330) and the LDL receptor-related protein (LRP)...
- The number and nature of emergency department encounters in patients with deep brain stimulatorsAndrew S Resnick
Department of Neurology, University of Florida, Gainesville, USA
J Neurol 257:122-31. 2010Deep brain stimulation (DBS) has become an increasingly common modality for control of several neurological disorders such as Parkinson's disease, dystonia, essential tremor (ET), and others...
- A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)Oraporn Sitburana
Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
Clin Neurol Neurosurg 112:106-9. 2010To perform a pilot study to investigate the relationship between the microlesion effect (MLE) seen in deep brain stimulation (DBS) of the ventralis intermedius nucleus (VIM) and subsequent tremor response and DBS parameter settings.
- Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the ratTine Wyckhuys
Laboratory for Clinical and Experimental Neurophysiology, Ghent University Hospital, Ghent, Belgium
Neuroimage 52:55-61. 2010Deep brain stimulation (DBS) is a promising experimental approach to treat various neurological disorders. However, the optimal stimulation paradigm and the precise mechanism of action of DBS are unknown...
- Development and application of a broadly sensitive dried-blood-spot-based genotyping assay for global surveillance of HIV-1 drug resistanceChunfu Yang
Division of Global AIDS, International Laboratory Branch, DGHA, NCHHSTP, CDC, Mail Stop A 11, 1600 Clifton Road, Atlanta, GA 30333, USA
J Clin Microbiol 48:3158-64. 2010..We have developed and applied a broadly sensitive dried-blood-spot (DBS)-based genotyping assay for surveillance of HIV-1 DR in international settings...
- Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearanceT E Willnow
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
J Biol Chem 267:26172-80. 1992The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and gp330, two members of the low density lipoprotein receptor gene family, share a multitude of cysteine-rich repeats...
- Renal tubule gp330 is a calcium binding receptor for endocytic uptake of proteinE I Christensen
Department of Cell Biology, University of Aarhus, Denmark
J Histochem Cytochem 40:1481-90. 1992b>gp330, a large glycoprotein located in renal proximal tubules, has sequence similarities with the low-density lipoprotein receptor and the alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein...
- An evaluation of rating scales utilized for deep brain stimulation for dystoniaFrandy Susatia
Movement Disorders Center, Department of Neurology, University of Florida, Gainesville, FL 32610, USA
J Neurol 257:44-58. 2010The objective of this study was to examine globus pallidus internus deep brain stimulation (GPi-DBS) outcomes in primary and secondary dystonia, derived from blinded ratings using two scales and two raters...
- Critical role of the pleckstrin homology domain in Dbs signaling and growth regulationErnesto J Fuentes
Department of Biochemistry and Biophysics, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:21188-96. 2003..We determined previously that the PH domain of Dbs was critical for the intrinsic catalytic activity of the DH domain in vitro and for Dbs transformation in vivo...
- Receptor-associated protein is important for normal processing of megalin in kidney proximal tubulesH Birn
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
J Am Soc Nephrol 11:191-202. 2000..RAP also binds to the related 600-kD multiligand endocytic receptor megalin expressed in many absorptive epithelia including renal proximal tubule...
- Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone releaseM Marino
Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 275:7125-37. 2000..Here we show that megalin (gp330), a Tg receptor on thyroid cells, plays a role in Tg transcytosis...
Research Grants105 found, 100 shown here
- DEEP BRAIN STIMULATION FOR PARKINSONS DISEASEJERROLD VITEK; Fiscal Year: 2005The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
- MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PDTamara Hershey; Fiscal Year: 2009..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
- MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PDTAMARA G HERSHEY; Fiscal Year: 2010..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
- MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONSMark George; Fiscal Year: 2002DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
- EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROLFay Horak; Fiscal Year: 2005..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
- Deep Brain Stimulation in the Parkinsonian MonkeyJERROLD VITEK; Fiscal Year: 2006..parkinsonism and other movement disorders has been revolutionized by the introduction of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) as a highly effective treatment ..
- Deep Brain Stimulation in Parkinson's ModelsMarjorie Anderson; Fiscal Year: 2006Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, the mechanisms by which HF-DBS exerts its ..
- Model-Based Optimization of Clinical Deep Brain StimulationCameron McIntyre; Fiscal Year: 2007Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus inturnus (GPi) represent established therapies for medically refractory Parkinson's disease (PD)...
- Model-Based Optimization of Clinical Deep Brain StimulationCameron McIntyre; Fiscal Year: 2010Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus inturnus (GPi) represent established therapies for medically refractory Parkinson's disease (PD)...
- FMRI Evaluation of DBS in Parkinson's DiseaseMICHEAL PHILLIPS; Fiscal Year: 2009..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
- DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PDRobert Turner; Fiscal Year: 2006Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's disease (PD)...
- FMRI Evaluation of DBS in Parkinson's DiseaseMICHEAL PHILLIPS; Fiscal Year: 2007..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
- Evaluation of MRI Safety for Deep Brain StimulationAli Rezai; Fiscal Year: 2004There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
- Cortical and basal ganglia local field potentials in human movement disordersPhilip A Starr; Fiscal Year: 2010..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
- Thalamostriatal System in ParkinsonismTHOMAS N WICHMANN; Fiscal Year: 2010..The CM/PF complex is increasingly targeted for neurosurgical interventions, such as deep brain stimulation (DBS), in the treatment of conditions such as Tourette syndrome, Parkinson's disease and others...
- Deep Brain Stimulation in the Parkinsonian MonkeyJerrold L Vitek; Fiscal Year: 2010..Despite the widespread use of DBS, its mechanism of action remains unclear...
- Deep Brain Stimulation in the Parkinsonian MonkeyJERROLD VITEK; Fiscal Year: 2009..Despite the widespread use of DBS, its mechanism of action remains unclear...
- Deep Brain Microelectrode Array For Functional NeurosurgeryJAMILLE HETKE; Fiscal Year: 2007Deep brain stimulation (DBS) devices - 'brain pacemakers' - have recently emerged as an exciting novel neurotechnology for treating severe movement disorders, such as Parkinson's Disease and Essential Tremor...
- Deep Brain Stimulation Array for NeuromodulationRIO VETTER; Fiscal Year: 2007Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
- Motor Learning in Parkinson's DiseaseM Ghilardi; Fiscal Year: 2002..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
- DEEP BRAIN STIMULATION IN PARKINSONISMJERROLD VITEK; Fiscal Year: 2001The aim of this study is to assess the effect of deep brain stimulation (DBS) within different nodal portions of the basal ganglia-thalamocortical circuit, i.e...
- Influence of the Basal Ganglia on Cerebellar ActionAlan Gibson; Fiscal Year: 2004..Deep brain stimulation (DBS) is proving to be a surprisingly effective approach for the control of movement disorders associated with diseases ..