megalin

Summary

Gene Symbol: megalin
Description: low density lipoprotein receptor-related protein 2
Alias: DBS, GP330, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, low-density lipoprotein receptor-related protein 2, megalin
Species: human

Top Publications

  1. doi A megalin polymorphism associated with promoter activity and Alzheimer's disease risk
    Teo Vargas
    Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010
  2. doi A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population
    Li ling Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Clin Chim Acta 412:268-70. 2011
  3. pmc The unfolding story of megalin (gp330): now recognized as a drug receptor
    M G Farquhar
    J Clin Invest 96:1184. 1995
  4. ncbi Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide
    S M Hammad
    Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 272:18644-9. 1997
  5. pmc Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
  6. ncbi Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor
    R Raychowdhury
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Science 244:1163-5. 1989
  7. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
  8. ncbi gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Cell Sci 108:2361-8. 1995
  9. ncbi The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    M Z Kounnas
    Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 267:21162-6. 1992
  10. ncbi Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritis
    S P Makker
    Department of Pediatrics, University of California, Davis 95616
    J Immunol 151:6500-8. 1993

Detail Information

Publications194 found, 100 shown here

  1. doi A megalin polymorphism associated with promoter activity and Alzheimer's disease risk
    Teo Vargas
    Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010
    ..This observation suggests that many, perhaps most, cases of AD are caused by faulty clearance of Abeta. Megalin, which plays an important role in mediating Abeta clearance, is an attractive candidate gene for genetic ..
  2. doi A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population
    Li ling Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Clin Chim Acta 412:268-70. 2011
    LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD)...
  3. pmc The unfolding story of megalin (gp330): now recognized as a drug receptor
    M G Farquhar
    J Clin Invest 96:1184. 1995
  4. ncbi Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide
    S M Hammad
    Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 272:18644-9. 1997
    ..We have previously demonstrated that the endocytic receptor low density lipoprotein receptor-related protein-2/megalin (LRP-2), which is expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and ..
  5. pmc Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
    gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
  6. ncbi Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor
    R Raychowdhury
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Science 244:1163-5. 1989
    ..of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced...
  7. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
    We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
  8. ncbi gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Cell Sci 108:2361-8. 1995
    b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
  9. ncbi The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    M Z Kounnas
    Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 267:21162-6. 1992
    ..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
  10. ncbi Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritis
    S P Makker
    Department of Pediatrics, University of California, Davis 95616
    J Immunol 151:6500-8. 1993
    Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
  11. ncbi Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
    Claudius Luziga
    Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Mol Histol 38:65-77. 2007
    b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
  12. pmc Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    B V Zlokovic
    Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
    Proc Natl Acad Sci U S A 93:4229-34. 1996
    ..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
  13. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
    The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
  14. ncbi Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus
    J T Chun
    Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
    Exp Neurol 157:194-201. 1999
    Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
  15. pmc Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells
    M Lundstrom
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
    Am J Pathol 143:1423-35. 1993
    ..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
  16. doi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
    ....
  17. ncbi Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
    Michael S Okun
    Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 62:1250-5. 2005
    Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
  18. ncbi Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER
    D Biemesderfer
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
    Am J Physiol 264:F1011-20. 1993
    The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
  19. pmc Human cytomegalovirus: detection of congenital and perinatal infection in Argentina
    Angélica Lidia Distéfano
    Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
    BMC Pediatr 4:11. 2004
    ..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
  20. pmc Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 90:4082-6. 1993
    b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
  21. ncbi Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
    J Am Soc Nephrol 6:61-7. 1995
    The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
  22. ncbi Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule
    S Le Panse
    Department of Cell Biology, University of Aarhus, Denmark
    Exp Nephrol 5:375-83. 1997
    ..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
  23. ncbi Dental fear and pain: effect on patient's perception of the dentist
    K H Kunzelmann
    Polyclinic for Dental Care and Parodontology, Erlangen, FRG
    Community Dent Oral Epidemiol 18:264-6. 1990
    A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
  24. ncbi Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains
    Maria Paz Marzolo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Traffic 4:273-88. 2003
    b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
  25. ncbi Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells
    M L Elkjaer
    Department of Cell Biology, University of Aarhus, Denmark
    Eur J Cell Biol 67:57-72. 1995
    ..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
  26. ncbi Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Brain 130:1608-25. 2007
    Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
  27. doi [Deep brain stimulation for treatment of dystonia and tremor]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
    Nervenarzt 81:680-7. 2010
    Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
  28. pmc Induction of Heymann nephritis with a gp330/megalin fusion protein
    R Raychowdhury
    Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 148:1613-23. 1996
    ..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
  29. doi Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scans
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
    J Neurosurg 113:1234-41. 2010
    The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
  30. ncbi Deep brain stimulation for dystonia in adults. Overview and developments
    Joachim K Krauss
    Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
    Stereotact Funct Neurosurg 78:168-82. 2002
    ..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
  31. doi Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid
    André Bento-Abreu
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    J Neurochem 111:49-60. 2009
    ..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
  32. pmc Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells
    Michael Gekle
    Physiologisches Institut, Wurzburg, Germany
    J Physiol 552:471-81. 2003
    ..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
  33. pmc Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection
    Suresh B Boppana
    UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
    JAMA 303:1375-82. 2010
    ..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
  34. ncbi Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis
    M Marino
    Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Clin Endocrinol Metab 84:2468-74. 1999
    b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
  35. doi Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
  36. doi Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremor
    Takashi Morishita
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurosurg 112:491-6. 2010
    ..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
  37. doi Deep brain stimulation for camptocormia in dystonia and Parkinson's disease
    Hans Holger Capelle
    Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
    J Neurol 258:96-103. 2011
    ..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
  38. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
  39. pmc Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principle
    Young Min Shon
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 112:539-48. 2010
    ..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
  40. ncbi [Deep brain stimulation for Parkinson's disease and dystonia]
    Fusako Yokochi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Brain Nerve 61:473-83. 2009
    Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
  41. ncbi Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritis
    Alfonso Tramontano
    Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 172:2367-73. 2004
    ..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
  42. doi Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsy
    Angelo Franzini
    Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Stereotact Funct Neurosurg 86:373-81. 2008
    ..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
  43. ncbi Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobics
    R Moore
    Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
    Community Dent Oral Epidemiol 19:347-51. 1991
    ..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
  44. ncbi Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes
    Richard A Wennberg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
    Clin Neurophysiol 114:1403-18. 2003
    To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
  45. ncbi Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silica
    Antonio R Cestari
    Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
    J Colloid Interface Sci 309:402-11. 2007
    ..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
  46. ncbi Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330
    J J Kanalas
    Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
    Arch Biochem Biophys 299:255-60. 1992
    Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
  47. pmc Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Res Notes 3:60. 2010
    ..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
  48. doi The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditions
    E Coley
    Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Br J Neurosurg 23:179-83. 2009
    Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
  49. doi Deep brain stimulation for secondary dystonia: results in 8 patients
    P F Katsakiori
    Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
    Acta Neurochir (Wien) 151:473-8; discussion 478. 2009
    ..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
  50. ncbi Interactions between deep brain stimulation and levodopa in Parkinson's disease
    J G Nutt
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 57:1835-42. 2001
    To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
  51. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  52. pmc Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
    J Neurol Neurosurg Psychiatry 78:310-4. 2007
    Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
  53. doi Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
  54. ncbi Thalamic deep brain stimulation: comparison between unilateral and bilateral placement
    W Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
    Arch Neurol 58:218-22. 2001
    Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
  55. doi Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian rats
    Hisanao Akita
    Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
    Brain Res 1306:159-67. 2010
    ..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
  56. ncbi Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation
    Raghunatha R Yammani
    Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002
    The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
  57. doi Long-term effects of pallidal deep brain stimulation in tardive dystonia
    D Gruber
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Neurology 73:53-8. 2009
    ..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
  58. ncbi A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
  59. doi A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohort
    Houtan A Taba
    Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
    J Neurosurg 113:1224-9. 2010
    In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
  60. doi Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus
    Marek A Mirski
    Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
    Seizure 18:64-70. 2009
    ..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
  61. ncbi Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experience
    Micheal D Phillips
    Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiology 239:209-16. 2006
    ..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
  62. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
  63. doi Field Evaluation of Dried Blood Spots for Routine HIV-1 Viral Load and Drug Resistance Monitoring in Patients Receiving Antiretroviral Therapy in Africa and Asia
    Marjorie Monleau
    UMI 233 TransVIHMI, IRD, and Université de Montpellier 1, Montpellier, France
    J Clin Microbiol 52:578-86. 2014
    Dried blood spots (DBS) can be used in developing countries to alleviate the logistic constraints of using blood plasma specimens for viral load (VL) and HIV drug resistance (HIVDR) testing, but they should be assessed under field ..
  64. doi Disparities in access to deep brain stimulation surgery for Parkinson disease: interaction between African American race and Medicaid use
    Andrew K Chan
    Department of Neurological Surgery, Columbia University Medical Center, New York, New York
    JAMA Neurol 71:291-9. 2014
    ..To improve health care in this patient population, it is important to recognize and study the potential factors limiting access to care...
  65. doi Psychiatric side-effects of bilateral deep brain stimulation for movement disorders
    Marcus Pinsker
    Division of Stereotactic and Functional Neurosurgery, Department of General Neurosurgery, Neurosurgical Clinic, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, D 79106, Germany
    Acta Neurochir Suppl 117:47-51. 2013
    The effects of deep brain stimulation (DBS) on cognitive functions, and its psychiatric side-effects, are still controversial...
  66. doi Deep brain stimulation in children and young adults with secondary dystonia: the Children's Hospital Los Angeles experience
    Joffre E Olaya
    Division of Neurosurgery and
    Neurosurg Focus 35:E7. 2013
    ..Deep brain stimulation (DBS), specifically of the globus pallidus interna (GPi), has been shown to be extremely effective in primary ..
  67. doi Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock
    Chao Xu
    Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Sci Signal 5:ra39. 2012
    Ankyrin repeat family A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone deacetylases HDAC4 and HDAC5...
  68. doi Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery
    Remco A Koster
    University of Groningen, University Medical Center Groningen, Department of Hospital and Clinical Pharmacy, Laboratory for Clinical and Forensic Toxicology and Drugs Analysis, P O Box 30 001, 9700 RB Groningen, University of Groningen, The Netherlands Electronic address
    Talanta 115:47-54. 2013
    We developed a method for the analysis of four immunosuppressants in dried blood spot (DBS) samples to facilitate therapeutic drug monitoring for transplant patients outside the hospital...
  69. ncbi [Parkinson disease: deep cerebral stimulation]
    P Krack
    Departement des Neurosciences Cliniques et Biologiques, Centre Hospitalier Universitaire, INSERM U 318, Universite Joseph Fourier, Grenoble, France
    Rev Neurol (Paris) 158:S135-41. 2002
    The effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal pallidum (GPi) on the parkinsonian triad and on levodopa-induced dyskinesias are very similar...
  70. doi Neuropsychiatric deep brain stimulation for translational neuroimaging
    Anna Höflich
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neuroimage 79:30-41. 2013
    From a neuroimaging point of view, deep brain stimulation (DBS) in psychiatric disorders represents a unique source of information to probe results gained in functional, structural and molecular neuroimaging studies in vivo...
  71. doi Neurophysiology of deep brain stimulation
    Manuela Rosa
    Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Int Rev Neurobiol 107:23-55. 2012
    We review the data concerning the neurophysiology of deep brain stimulation (DBS) in humans, especially in reference to Parkinson's disease...
  72. ncbi [The indication of DBS in Parkinosn's disease (from a neurosurgical standpoint)]
    Chikashi Fukaya
    Division of Applied System Neuroscience, Department of Neurological Surgery, Nihon University School of Medicine
    Rinsho Shinkeigaku 52:1095-7. 2012
    It is obvious that deep brain stimulation (DBS) is one of the useful treatment choices for progressive Parkinson disease (PD)...
  73. doi Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task
    Lily R Aleksandrova
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Behav Brain Res 245:76-82. 2013
    Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a treatment option for the motor symptoms of Parkinson's disease (PD). However, several recent studies have found an association between STN-DBS and increased impulsivity...
  74. pmc Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets
    Iuliana Ionita-Laza
    Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 90:1002-13. 2012
    ....
  75. pmc Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex
    Anne L Spieles-Engemann
    Department of Neurology, University of Cincinnati, OH, USA
    J Parkinsons Dis 1:123-36. 2011
    The mechanisms underlying the effects of long-term deep brain stimulation of the subthalamic nucleus (STN DBS) as a therapy for Parkinson's disease (PD) remain poorly understood...
  76. pmc Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation
    I P Whitehead
    Department of Microbiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Mol Cell Biol 19:7759-70. 1999
    b>Dbs was identified initially as a transforming protein and is a member of the Dbl family of proteins (>20 mammalian members)...
  77. doi Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population
    Nobuyuki Hamajima
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gene 503:131-6. 2012
    ..Since the low density lipoprotein-related protein 2 (megalin) encoded by LRP2 is a multi-ligand endocytic receptor expressed in many tissues including the kidney proximal ..
  78. doi Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration
    Tina Storm
    Department of Biomedicine, Universityof Aarhus, Aarhus, Denmark
    Nephrol Dial Transplant 28:585-91. 2013
    ..Studies of megalin-deficient mice suggest that the large multi-ligand endocytic receptor megalin plays an essential role in this ..
  79. pmc Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat
    Geoffrey Van der Plasse
    Department Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e33455. 2012
    Following the successful application of deep brain stimulation (DBS) in the treatment of Parkinson's disease and promising results in clinical trials for obsessive compulsive disorder and major depression, DBS is currently being tested ..
  80. doi Speed effects of deep brain stimulation for Parkinson's disease
    Fabian Klostermann
    Department of Neurology, CBF, Charite University Medicine Berlin, Berlin, Germany
    Mov Disord 25:2762-8. 2010
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made...
  81. doi Effects of unilateral pedunculopontine stimulation on electromyographic activation patterns during gait in individual patients with Parkinson's disease
    Pietro Caliandro
    Department of Neuroscience, Institute of Neurology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
    J Neural Transm 118:1477-86. 2011
    In Parkinson's disease (PD), the effects of deep brain stimulation of the pedunculopontine nucleus (PPTg-DBS) on gait has been object of international debate...
  82. doi LC-MS/MS sensitivity enhancement using 2D-SCX/RPLC and its application in the assessment of pharmacokinetics of clonidine in dried blood spots
    Fumin Li
    Covance Laboratories, Inc, Bioanalytical Chemistry, Madison, WI 53704, USA
    Bioanalysis 3:1577-86. 2011
    Dried blood spot (DBS) technology offers distinctive preclinical and clinical advantages primarily ascribed to microscale sampling (e.g., 40-80 µl per time point), and the nature of solid-state samples in filter papers...
  83. ncbi Retinol-binding protein stability in dried blood spots
    Masako Fujita
    Department of Anthropology, University of Washington, Seattle, WA 98195 3100, USA
    Clin Chem 53:1972-5. 2007
    ..A recently developed enzyme immunoassay for RBP uses serum or whole blood stored as dried blood spots (DBS). However, the stability of RBP in DBS has not been examined.
  84. pmc HIV-1 drug resistance testing from dried blood spots collected in rural Tanzania using the ViroSeq HIV-1 Genotyping System
    Asgeir Johannessen
    Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway
    J Antimicrob Chemother 66:260-4. 2011
    ..HIV-1 Genotyping System (Abbott Molecular, Des Plains, IL, USA) can be used in conjunction with dried blood spots (DBS) for clinical monitoring of drug resistance in patients who fail antiretroviral treatment (ART) in rural Tanzania.
  85. pmc Feasibility of neonatal dried blood spot retrieval amid evolving state policies (2009-2010): a Children's Oncology Group study
    Amy M Linabery
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    Paediatr Perinat Epidemiol 25:549-58. 2011
    Dried blood spots (DBS) are collected uniformly from US newborns to test for metabolic and other disorders. Because evidence exists for prenatal origins of some diseases, DBS may provide unique prenatal exposure records...
  86. doi Evaluation of blood microsampling techniques and sampling sites for the analysis of drugs by HPLC-MS
    Christopher Smith
    Clinical Pharmacology Department, Alderley, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    Bioanalysis 3:145-56. 2011
    ..Blood microsamples were collected in three ways, either as a dried blood spot (DBS), a blood sample collected in a micropipette placed in a plastic tube and mixed with water or as plasma in the ..
  87. doi Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin
    Craig Slattery
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Cell Physiol Biochem 27:171-8. 2011
    The scavenger receptor megalin binds to albumin in the microvilli of the renal proximal tubule, and transports the ligand to the intravillar cleft for processing by endocytosis...
  88. ncbi Deep brain stimulation in the treatment of secondary dystonia
    Jian Guo Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
    Chin Med J (Engl) 119:2069-74. 2006
    ..in whom symptoms are inadequately controlled with pharmacologic measures, the use of deep brain stimulation (DBS) can improve symptoms and enhance functional capacity...
  89. ncbi Implantation of electrodes for deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease with the aid of intraoperative microrecording under general anesthesia
    Frank Hertel
    Department of Neurosurgery, Brüderkrankenhaus, Trier, Germany
    Neurosurgery 59:E1138; discussion E1138. 2006
    Deep brain stimulation (DBS) is widely accepted in the treatment of advanced Parkinson's disease (PD) and other movement disorders. The standard implantation procedure is performed under local anesthesia (LA)...
  90. doi LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimens
    Andrea Faller
    Institute of Legal and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Anal Bioanal Chem 401:1163-6. 2011
    ..Analysis of dried blood spots (DBS) is particularly advantageous for the determination of delicate analytes such as PEth...
  91. doi An evaluation of rating scales utilized for deep brain stimulation for dystonia
    Frandy Susatia
    Movement Disorders Center, Department of Neurology, University of Florida, Gainesville, FL 32610, USA
    J Neurol 257:44-58. 2010
    The objective of this study was to examine globus pallidus internus deep brain stimulation (GPi-DBS) outcomes in primary and secondary dystonia, derived from blinded ratings using two scales and two raters...
  92. pmc Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidity
    J Gerardo Garcia-Lerma
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Antimicrob Chemother 64:33-6. 2009
    Dried blood spots (DBS) and dried plasma spots (DPS) are considered convenient alternatives to serum and plasma for HIV drug resistance testing in resource-limited settings...
  93. doi Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studies
    Yuanyuan Li
    Advion BioServices, Inc, Ithaca, NY, USA
    Bioanalysis 3:2501-14. 2011
    Dried blood spot (DBS) technology was evaluated for the quantitative determination of guanfacine in human blood in clinical studies...
  94. doi Determination of moxifloxacin in dried blood spots using LC-MS/MS and the impact of the hematocrit and blood volume
    D H Vu
    Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1063-70. 2011
    ..sampling for TDM is facing logistical challenges, especially in limited resource areas, and dried blood spots (DBS) sampling may offer a chance to overcome this problem...
  95. doi The number and nature of emergency department encounters in patients with deep brain stimulators
    Andrew S Resnick
    Department of Neurology, University of Florida, Gainesville, USA
    J Neurol 257:122-31. 2010
    Deep brain stimulation (DBS) has become an increasingly common modality for control of several neurological disorders such as Parkinson's disease, dystonia, essential tremor (ET), and others...
  96. doi A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)
    Oraporn Sitburana
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Clin Neurol Neurosurg 112:106-9. 2010
    To perform a pilot study to investigate the relationship between the microlesion effect (MLE) seen in deep brain stimulation (DBS) of the ventralis intermedius nucleus (VIM) and subsequent tremor response and DBS parameter settings.
  97. pmc Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson's disease
    V J Khandwala
    Dept Biomedical Eng, Univ Rochester, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:1553-6. 2009
    Therapeutic benefits of subthalamic nucleus (STN) deep brain stimulation (DBS) for motor symptoms of Parkinson's disease (PD) are well-documented. However, the mechanisms underlying motor improvement with DBS remain poorly understood...
  98. doi Effective inhibition of substantia nigra by deep brain stimulation fails to suppress tonic epileptic seizures
    Safa Shehab
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, UAE
    Neurobiol Dis 43:725-35. 2011
    Experimental and clinical data suggest that high-frequency deep brain stimulation (DBS) of different subcortical structures can be used to control or modulate epileptic seizures...
  99. doi Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat
    Tine Wyckhuys
    Laboratory for Clinical and Experimental Neurophysiology, Ghent University Hospital, Ghent, Belgium
    Neuroimage 52:55-61. 2010
    Deep brain stimulation (DBS) is a promising experimental approach to treat various neurological disorders. However, the optimal stimulation paradigm and the precise mechanism of action of DBS are unknown...
  100. doi Assessment of DNA contamination from dried blood spots and determination of DNA yield and function using archival newborn dried blood spots
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, Georgia 30341, United States
    Clin Chim Acta 402:107-13. 2009
    Residual dried blood spots (DBS) from newborn screening programs are often stored for years and are sometimes used for epidemiological studies...

Research Grants34

  1. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..The electrical stimulation of subcortical areas of the brain (deep brain stimulation - DBS) is an effective alternative option, which is rather restricted due to its invasiveness and associated risks...
  2. Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons Disease
    JAIME A KAMINER; Fiscal Year: 2013
    ..Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) stimulation will be applied to 6-OHDA lesioned ..
  3. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
    ..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
  4. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that ..
  5. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ..Despite the widespread use of DBS, its mechanism of action remains unclear...
  6. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy ..
  7. Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulation
    ROBERT STERLING TURNER; Fiscal Year: 2013
    ..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing abnormalities in GPi ..
  8. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010
    Electrical stimulation in deep brain structures (DBS) has developed into an effective treatment for advanced Parkinson's disease and essential tremor...
  9. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
  10. Effects of DBS on sensorimotor processes
    Jing Yu Chang; Fiscal Year: 2005
    ..Deep brain stimulation (DBS) of subthalamic nucleus (STN) has been used increasingly in the clinic to alleviate Parkinsonian syndromes (PS) ..
  11. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
  12. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..Chronic high frequency deep brain stimulation (DBS) has recently emerged as a possible therapeutic option in refractory cases incapacitated by their tics...
  13. Evaluation of MRI Safety for Deep Brain Stimulation
    Ali Rezai; Fiscal Year: 2004
    There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
  14. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
  15. Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2013
    ..motor signs in Parkinson's disease (PD), and the improvement in motor function during deep brain stimulation (DBS)...
  16. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  17. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..of cortical activation on functional MRI (fMRI), that the cognitive and motor effects of deep brain stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the frontal lobe to ..
  18. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
  19. Clinical and neurophysiological study of subthalamic brain stimulation in PD
    HARRISON CARROLL WALKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies, cell transplant strategies, and the delivery of gene-delivered growth factors ..
  20. Local field potentials in the basal ganglia
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..Studies in humans, using implanted deep brain stimulation (DBS) electrodes to record LFPs, have suggested that high-amplitude, low frequency oscillations develop in parkinsonism ..
  21. Mechanism of Action of Deep Brain Stimulation
    Kendall H Lee; Fiscal Year: 2012
    ..neuroengineering and neurosurgery will help the applicant elucidate the mechanisms by which Deep Brain Stimulation (DBS) treats Parkinson's disease...
  22. DEEP BRAIN STIMULATION FOR PARKINSONS DISEASE
    JERROLD VITEK; Fiscal Year: 2005
    The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
  23. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
  24. DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PD
    Robert Turner; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's ..
  25. FMRI Evaluation of DBS in Parkinson's Disease
    MICHEAL PHILLIPS; Fiscal Year: 2009
    ..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
  26. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..we performed two large-scale studies to determine the feasibility of quantitating TRECs using dried blood spots (DBS) to detect SCID newborns...
  27. Trafficking of LRP and Megalin in Polarized Cells
    Guojun Bu; Fiscal Year: 2006
    DESCRIPTION (provided by applicant) Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large membrane glycoproteins that belong to the LDL receptor gene family...
  28. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
    ..of the very cost effective and accurate method for screening newborn infants using filter paper dried blood spots (DBS) can be applied to pediatric and adult populations to detect diseases before disability and severe symptoms develop,..
  29. SERUM PROTEIN BINDING THE HN AUTOANTIGEN
    JOHN KANALAS; Fiscal Year: 1993
    ..Although a glycoprotein isolated form the brush border (gp330) is generally recognized as the putative antigen of HN, it's normal function has yet to be determined...
  30. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Known as deep brain stimulation (DBS), it has been successfully used to treat various human brain disorders (e.g...
  31. Ethics of Control and Consent in Brain Stimulation for Parkinson Disease
    CYNTHIA M S KUBU; Fiscal Year: 2010
    ..the ethical challenges inherent in participants'considerations of control using Deep Brain Stimulation (DBS) for the treatment of Parkinson disease (PD) as a paradigm...
  32. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
  33. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
  34. Advanced Technology and Tools for DBS Programming for Speech Functionality
    Craig van Horne; Fiscal Year: 2009
    ..Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders...