Gene Symbol: MEF2D
Description: myocyte enhancer factor 2D
Alias: myocyte-specific enhancer factor 2D, MADS box transcription enhancer factor 2, polypeptide D
Species: human
Products:     MEF2D

Top Publications

  1. Linseman D, Bartley C, Le S, Laessig T, Bouchard R, Meintzer M, et al. Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. J Biol Chem. 2003;278:41472-81 pubmed
    ..Removal of depolarization or KN93 addition resulted in dephosphorylation of HDAC5 and its co-precipitation with MEF2D. HDAC5 nuclear translocation triggered by KN93 induced a marked loss of MEF2 activity and subsequent apoptosis...
  2. Youn H, Grozinger C, Liu J. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J Biol Chem. 2000;275:22563-7 pubmed
    ..Together, HDAC4, MITR, and Cabin1 constitute a family of calcium-sensitive transcriptional repressors of MEF2. ..
  3. Lu J, McKinsey T, Nicol R, Olson E. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc Natl Acad Sci U S A. 2000;97:4070-5 pubmed
  4. Potthoff M, Olson E. MEF2: a central regulator of diverse developmental programs. Development. 2007;134:4131-40 pubmed
    ..We review the myriad roles of MEF2 in development and the mechanisms through which it couples developmental, physiological and pathological signals with programs of cell-specific transcription. ..
  5. Zaliova M, Stuchly J, Winkowska L, Musilova A, Fiser K, Slámová M, et al. Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort. Haematologica. 2019;: pubmed publisher
    ..The frequency of DUX4-rearranged, BCR-ABL1-like, ZNF384-rearranged, ETV6-RUNX1-like, iAMP21 and MEF2D-rearranged subtypes was 27%, 15%, 5%, 5%, 4% and 2%, respectively; 43% of cases were not classified into any of ..
  6. Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, et al. Expression of MEF2 genes during human cardiac development. Tohoku J Exp Med. 1999;187:15-23 pubmed
    ..Expression of all four MEF2 transcripts (MEF2A, MEF2B, MEF2C, and MEF2D) were detected in all developmental stage of the human heart, while Mef2b transcripts were down-regulated in mouse ..
  7. Fu X, Yang J, Wu X, Lin Q, Zeng Y, Xia Q, et al. Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China. Clin Invest Med. 2019;42:E21-E30 pubmed publisher
    ..The SNPs examined included rs2651899 (PRDM16 ), rs2274316 (MEF2D ), rs7577262 (TRPM8) and rs11172113 (LRP1)...
  8. Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, et al. Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Oncogene. 2019;38:2263-2274 pubmed publisher
    b>MEF2D fusion genes are newly discovered recurrent gene abnormalities that are detected in approximately 5% of acute lymphoblastic leukemia cases...
  9. Ichihara M, Kamiya T, Hara H, Adachi T. The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or p300 in SOD3 expression in THP-1 cells. Free Radic Res. 2018;52:799-807 pubmed publisher
    ..The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300...

More Information

Publications131 found, 100 shown here

  1. Andzelm M, Vanness D, Greenberg M, Linden D. A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Cell Rep. 2019;26:1089-1097.e3 pubmed publisher
    ..Here, we test the hypothesis that cerebellar LTD requires postsynaptic activation of MEF2. Knockdown of MEF2D produces suppression of the transcription-dependent late phase of LTD in cultured Purkinje cells...
  2. Farias F, Dahlqvist J, Kozyrev S, Leonard D, Wilbe M, Abramov S, et al. A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts. Eur J Hum Genet. 2019;27:432-441 pubmed publisher
    ..diseases, we identified a rare regulatory variant rs200395694:G > T located in intron 4 of the MEF2D gene encoding the myocyte-specific enhancer factor 2D transcription factor and associated with SLE in Swedish ..
  3. Zhao W, Zhang D, Qin P, Zhang J, Cui X, Gao J, et al. Long non-coding RNA EPIC1 inhibits viability and invasion of osteosarcoma cells by promoting MEF2D ubiquitylation. Int J Biol Macromol. 2019;128:566-573 pubmed publisher
    ..The expression of EPIC1 and MEF2D was determined by quantitative real-Time PCR and western blotting...
  4. Runfola V, Sebastian S, Dilworth F, Gabellini D. Rbfox proteins regulate tissue-specific alternative splicing of Mef2D required for muscle differentiation. J Cell Sci. 2015;128:631-7 pubmed publisher
    Among the Mef2 family of transcription factors, Mef2D is unique in that it undergoes tissue-specific splicing to generate an isoform that is essential for muscle differentiation...
  5. Martis P, Dudley A, Bemrose M, Gazda H, Smith B, Gazda L. MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells. BMC Cancer. 2018;18:1217 pubmed publisher
    ..up-regulated the activity of the MEF2 transcription factor as well as altered the transcription of MEF2b and MEF2d isoforms in targeted tumor cells...
  6. Guo B, Zheng C, Cai W, Cheng J, Wang H, Li H, et al. Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. J Agric Food Chem. 2016;64:5324-33 pubmed publisher
    ..The mechanisms also involved activating transcriptional factor myocyte enhancer factor 2D (MEF2D) via regulation of AKT-GSK3? signaling...
  7. Li J, Dai Y, Lilljebjörn H, Shen S, Cui B, Bai L, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A. 2018;115:E11711-E11720 pubmed publisher
    ..Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3-PBX1 fusions, ETV6-RUNX1-positive/ETV6-RUNX1-like, DUX4 fusions, ..
  8. Wolber L, Steves C, Tsai P, Deloukas P, Spector T, Bell J, et al. Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. PLoS ONE. 2014;9:e105729 pubmed publisher
    ..75, p=1.2 × 10(-4)) and MEF2D (cg08156349, r= -0.75, p=1.4 × 10(-4))...
  9. Yang S, Gao L, Lu F, Wang B, Gao F, Zhu G, et al. Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death. J Neuroinflammation. 2015;12:33 pubmed publisher
    ..Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission of extracellular signals and activation of the genetic programs ..
  10. Zhang M, Mao D, Zhang W. The pathogenic role of MEF2D-SS18 fusion gene in B-cell acute lymphoblastic leukemia. Biochem Biophys Res Commun. 2018;496:1331-1336 pubmed publisher
    ..leukemia (B-ALL) is characterized by various fusion genes resulted from chromosome translocations, and MEF2D related fusions are recently identified in a B-ALL subtype with relatively worse survival...
  11. Zhou Z, Lin Z, He Y, Pang X, Wang Y, Ponnusamy M, et al. The Long Noncoding RNA D63785 Regulates Chemotherapy Sensitivity in Human Gastric Cancer by Targeting miR-422a. Mol Ther Nucleic Acids. 2018;12:405-419 pubmed publisher
    ..422a (miR-422a) expression, which was involved in the downregulation of expression of myocyte enhancer factor-2D (MEF2D) and drug sensitivity...
  12. Chen L, Cheng B, Li L, Zhan S, Wang L, Zhong T, et al. The molecular characterization and temporal-spatial expression of myocyte enhancer factor 2 genes in the goat and their association with myofiber traits. Gene. 2015;555:223-30 pubmed publisher
    The myocyte enhancer factor-2 (MEF2) gene family in vertebrates includes MEF2A, MEF2B, MEF2C, and MEF2D, which have important functions in the regulation of muscular growth and development...
  13. Zhao X, Liu M, Li D. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis. Mol Cell Biochem. 2015;400:1-7 pubmed publisher
    ..The suppression of miR-122 abolished the effect of OA on lung cancer cells. CCNG1 and MEF2D, two putative miR-122 targets, were found to be downregulated by OA treatment...
  14. Hwang J, Chou C, Medvar B, Knepper M, Jung H. Identification of ?-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells. Am J Physiol Renal Physiol. 2017;313:F30-F46 pubmed publisher
    ..with ?-catenin in the regulation of Aqp2 gene transcription, specifically Jun, Junb, Jund, Atf1, Atf2, Mef2d, Usf1, Max, Pou2f1, and Rxra...
  15. Li M, Liu Z, Zhang Z, Liu G, Sun S, Sun C. miR-103 promotes 3T3-L1 cell adipogenesis through AKT/mTOR signal pathway with its target being MEF2D. Biol Chem. 2015;396:235-44 pubmed publisher
    ..proved that this function of miR-103 worked through activating AKT/mTOR signal pathway and impairing target gene MEF2D. By inhibiting and over-expressing the MEF2D gene, we found that MEF2D had a negative role in regulating adipocyte ..
  16. Andzelm M, Cherry T, Harmin D, Boeke A, Lee C, Hemberg M, et al. MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers. Neuron. 2015;86:247-63 pubmed publisher
    ..Here we show that despite being expressed in virtually all mammalian tissues, in the retina MEF2D binds to retina-specific enhancers and controls photoreceptor cell development...
  17. Arosio A, Sala G, Rodriguez Menendez V, Grana D, Gerardi F, Lunetta C, et al. MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients. Mol Cell Neurosci. 2016;74:10-7 pubmed publisher
    Amyotrophic lateral sclerosis (ALS) is a progressive neuro-muscular disease characterized by motor neuron loss. MEF2D and MEF2C are members of the myocyte enhancer factor 2 family (MEF2), a group of transcription factors playing crucial ..
  18. Wales S, Hashemi S, Blais A, McDermott J. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014;42:11349-62 pubmed publisher
    ..Furthermore, MEF2D functions as a p38MAPK-dependent repressor of Dusp6 in myoblasts...
  19. Ke K, Shen J, Song Y, Cao M, Lu H, Liu C, et al. CDK5 contributes to neuronal apoptosis via promoting MEF2D phosphorylation in rat model of intracerebral hemorrhage. J Mol Neurosci. 2015;56:48-59 pubmed publisher
    ..Meantime, myocyte enhancer factor 2D (MEF2D), a pro-survival transcription factor which could be phosphorylated inactivation by CDK5, also exhibited high ..
  20. Wang Y, Wang J, Liu H, Zhang R, Zhang T, Gan X, et al. Discovery, Characterization, and Functional Study of a Novel MEF2D CAG Repeat in Duck (Anas platyrhynchos). DNA Cell Biol. 2016;35:398-409 pubmed publisher
    Myocyte enhancer transcription factor 2D (MEF2D) is an important transcription factor for promoting the growth and development of muscle...
  21. Estrella N, Clark A, Desjardins C, Nocco S, Naya F. MEF2D deficiency in neonatal cardiomyocytes triggers cell cycle re-entry and programmed cell death in vitro. J Biol Chem. 2015;290:24367-80 pubmed publisher
    ..b>MEF2D is a key transcriptional mediator of pathological remodeling in the adult heart downstream of various stress-..
  22. Kumar S, Jahangir Alam M, Prabhakar P, Ahmad S, Maulik S, Sharma M, et al. Proteomic analysis of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol-induced cardiac hypertrophy in rats. J Ethnopharmacol. 2017;198:98-108 pubmed publisher
    ..b>MEF2D binding activity was increased by ISO and TA restored it to the baseline level...
  23. Song Z, Feng C, Lu Y, Gao Y, Lin Y, Dong C. Overexpression and biological function of MEF2D in human pancreatic cancer. Am J Transl Res. 2017;9:4836-4847 pubmed
    To explore the expression, clinical significance, biological function, and potential mechanism of MEF2D in pancreatic cancer, the expression of MEF2D in human pancreatic cancer tissues and corresponding adjacent normal tissues was ..
  24. Lobanok E, Kvacheva Z, Pinchuk S, Volk M, Mezhevkina L, Fesenko E, et al. [The influence of fibroblast growth factor (FGF2) on cardiomyocytes differentiation of mesenchymal stem cells of bone marrow ex vivo]. Biofizika. 2014;59:360-8 pubmed after the combined action of a differentiating agent and growth factor was manifested in an increase in Mef2A, Mef2D and gene transcription and a rise of ionized Ca2+ concentration in cytoplasm keeping cell viability and ..
  25. Neely M, Robert E, Baucum A, Colbran R, Muly E, Deutch A. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res. 2009;1274:55-65 pubmed publisher
    ..We have analyzed the regional, cellular, and subcellular expression of MEF2A and MEF2D in the rodent brain...
  26. Chen Z, Liu A, Liu Q, Chen J, Li W, Chao X, et al. MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells. Mol Neurobiol. 2017;54:2209-2222 pubmed publisher
    ..Myocyte enhancer factor 2 (MEF2D) is known to promote neuronal survival in several models, and several survival and death signals converge on MEF2D ..
  27. Liu G, Cuffe S, Liang S, Azad A, Cheng L, Brhane Y, et al. BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial. Clin Cancer Res. 2017;23:2460-2470 pubmed publisher
    ..04). ChIP and promoter swap experiments confirmed binding of MEF2D and HDAC9 only to homozygotes of each polymorphism, associated with reduced promoter activity in the DH...
  28. Basile V, Baruffaldi F, Dolfini D, Belluti S, Benatti P, Ricci L, et al. NF-YA splice variants have different roles on muscle differentiation. Biochim Biophys Acta. 2016;1859:627-38 pubmed publisher
    ..NF-YAl activates directly Mef2D, Six genes, and p57kip2 (Cdkn1c), and indirectly the myogenic regulatory factors (MRFs)...
  29. Li S, Hang L, Ma Y. FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number. Hear Res. 2016;332:39-45 pubmed publisher
    ..Expression of FGF22 and myocyte enhancer factor 2D (MEF2D) was assayed with RT-PCR...
  30. Hu S, Wang L, Mak S, Zhang Z, Xu D, Li H, et al. Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular Med. 2016;18:561-572 pubmed
    ..Very encouragingly, we found that DT-010, but not DSS or TMP, could enhance myocyte enhancer factor 2D (MEF2D) transcriptional activity using luciferase reporter gene assay...
  31. Masuda T, Berlinicke C, Zack D. Gene regulation: it matters who you hang out with. Neuron. 2015;86:7-9 pubmed publisher
    ..Andzelm, Cherry et al. (2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific ..
  32. An X, Fang J, Yu Z, Lin Q, Lu C, Qu H, et al. Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility. Clin Genet. 2017;92:143-149 pubmed publisher
    ..The genotypic and allelic distributions of MEF2D rs2274316 and ASTN2 rs6478241 were significantly different between migraine patients and controls...
  33. Rybicka A, Mucha J, Majchrzak K, Taciak B, Hellmen E, Motyl T, et al. Analysis of microRNA expression in canine mammary cancer stem-like cells indicates epigenetic regulation of transforming growth factor-beta signaling. J Physiol Pharmacol. 2015;66:29-37 pubmed
    ..pathways showed that the most important genes were: TGFBR1, TGFBR2, SOS1, CHUK, PDGFRA, SMAD2, MEF2A, MEF2C and MEF2D. All of them are involved in tumor necrosis factor-beta signaling and may indicate its important role in cancer ..
  34. Hobson G, Krahe R, Garcia E, Siciliano M, Funanage V. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. Genomics. 1995;29:704-11 pubmed
    ..The localization of MEF2A to chromosome 15q26, MEF2B to 19p12, MEF2C to 5q14, and MEF2D to 1q12-q23 verifies the existence of at least four distinct loci for members of this gene family.
  35. Fang X, Robinson J, Wang Hu J, Jiang L, Freeman D, Rivkees S, et al. cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes. Am J Physiol Cell Physiol. 2015;309:C425-36 pubmed publisher
    ..associated with hypertrophic cardiomyopathy (HCM), including Myh6, Myh7, Myh7b, Tnni3, Anp, Bnp, Gata4, Mef2c, Mef2d, Nfatc1, miR208a, and miR208b...
  36. Song L, Li D, Zhao Y, Gu Y, Zhao D, Li X, et al. miR-218 suppressed the growth of lung carcinoma by reducing MEF2D expression. Tumour Biol. 2016;37:2891-900 pubmed publisher
    ..Recently, myocyte enhancer factor 2D (MEF2D) has been reported to promote the growth of liver cancer, but its implication in lung cancer is still unknown...
  37. Liu Y, Wang B, Zhang W, Huang J, Li B, Zhang M, et al. Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia. EBioMedicine. 2016;8:173-183 pubmed publisher
    ..Among the 29 newly identified in-frame gene fusions, those involving MEF2D and ZNF384 were clinically relevant and were demonstrated to perturb B-cell differentiation, with EP300-ZNF384 ..
  38. Hu S, Cui W, Zhang Z, Mak S, Xu D, Li G, et al. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J Mol Neurosci. 2015;57:561-70 pubmed publisher
    ..Furthermore, 6OHDA substantially decreased the transcriptional activity of myocyte enhancer factor 2D (MEF2D), a transcription factor that plays an important role in dopaminergic neuron survival, and reduced nuclear ..
  39. Tomizawa D. Acute leukemia in adolescents and young adults. Rinsho Ketsueki. 2017;58:2160-2167 pubmed publisher
    ..the biological nature of acute leukemia in AYAs; higher frequency of Ph-like ALL and rearrangements in DUX4, ERG, MEF2D, and ZNF384 genes in AYAs with ALL and higher frequency of FLT3-ITD, NPM1, IDH1/2, DNMT3A, ASXL1, TET2, and CEBPA ..
  40. Singh R, Xia Z, Bland C, Kalsotra A, Scavuzzo M, Curk T, et al. Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. Mol Cell. 2014;55:592-603 pubmed publisher
    ..Integration of Rbfox2-dependent splicing outcomes from RNA-seq with Rbfox2 iCLIP data identified Mef2d and Rock2 as Rbfox2 splicing targets...
  41. Fang X, Mei W, Barbazuk W, Rivkees S, Wendler C. Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1471-87 pubmed publisher
    ..genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499)...
  42. Black B, Ligon K, Zhang Y, Olson E. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996;271:26659-63 pubmed
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins. ..
  43. Yang Q, She H, Gearing M, Colla E, Lee M, Shacka J, et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science. 2009;323:124-7 pubmed publisher
    ..cell line, we found that chaperone-mediated autophagy regulated the activity of myocyte enhancer factor 2D (MEF2D), a transcription factor required for neuronal survival...
  44. Breitbart R, Liang C, Smoot L, Laheru D, Mahdavi V, Nadal Ginard B. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development. 1993;118:1095-106 pubmed
    ..Indeed, while MEF2D mRNAs are ubiquitous, the protein is highly restricted to those cell types that contain this activity, implicating ..
  45. Zhao Y, Zhao L, Wang P, Miao Y, Liu Y, Wang Z, et al. Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin. J Neurosci Res. 2015;93:1891-902 pubmed publisher
    ..reporter assays revealed that miR-18a bound to the 3'-untranslated region (3'UTR) of myocyte enhancer factor 2D (MEF2D)...
  46. HIGGINS G, Georgoff P, Nikolian V, Allyn Feuer A, Pauls B, Higgins R, et al. Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury. Pharm Res. 2017;34:1658-1672 pubmed publisher
    ..Genes which encode the transcription factors (TFs) that specify neuronal cell fate, including MEF2D, MYT1L, NEUROD1, PAX6 and TBR1, and their target genes, are induced by VPA...
  47. Nagar S, Trudler D, McKercher S, Piña Crespo J, Nakanishi N, Okamoto S, et al. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci. 2017;58:3741-3749 pubmed publisher
    ..We used mouse genetic models and improved methods for retinal explant cultures. Retinas were enucleated from Mef2d+/+ and Mef2d-/- mice, stained for MEF2 proteins and outer nuclear layer thickness, and assayed for apoptotic cells...
  48. Johnatty S, Tyrer J, Kar S, Beesley J, Lu Y, Gao B, et al. Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium. Clin Cancer Res. 2015;21:5264-76 pubmed publisher
    ..8, and rs6674079 is perfectly correlated with another SNP within the super-enhancer MEF2D, expression levels of which were reportedly associated with prognosis in another solid tumor...
  49. Lozano Velasco E, Galiano Torres J, Jodar Garcia A, Aranega A, Franco D. miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes. Biomed Res Int. 2015;2015:391306 pubmed publisher
    ..but not in Sol8 skeletal muscle myoblasts, while overexpression of miR-125 resulted in selective upregulation of Mef2d in HL1 atrial cardiomyocytes and downregulation in Sol8 cells...
  50. Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García Calzón S, Peijs L, et al. Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects. BMC Med. 2017;15:39 pubmed publisher
    ..and transcriptional changes of myogenic transcription factors (MYOD1, MYOG, MYF5, MYF6, PAX7, MEF2A, MEF2C, and MEF2D), cell cycle regulators, metabolic enzymes and genes previously not linked to myogenesis, including IL32, ..
  51. Desjardins C, Naya F. Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors. J Biol Chem. 2017;292:10613-10629 pubmed publisher
    ..MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac ..
  52. Wang Z, Martin J, Mueller L, Caccamise A, Werner C, Neve R, et al. BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Biol Psychiatry. 2016;80:652-660 pubmed publisher
    ..are increased in the nucleus accumbens, resulting in increased binding of BRG1 to the promoter regions of Ctnnb1, Mef2d, and Dbn1...
  53. Chini C, Escande C, Nin V, Chini E. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem. 2010;285:40830-7 pubmed publisher
    ..These findings may lead to a better understanding of the biological roles of DBC1 and HDAC3 in metabolic diseases and cancer. ..
  54. Rastogi B, Raut S, Panda N, Rattan V, Radotra B, Khullar M. Overexpression of HDAC9 promotes oral squamous cell carcinoma growth, regulates cell cycle progression, and inhibits apoptosis. Mol Cell Biochem. 2016;415:183-96 pubmed publisher
    ..Subsequent investigation revealed that overexpression of HDAC9 contributes to OSCC carcinogenesis via targeting a transcription factor, MEF2D, and NR4A1/Nur77, a pro-apoptotic MEF2 target.
  55. Nagar S, Noveral S, Trudler D, Lopez K, McKercher S, Han X, et al. MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proc Natl Acad Sci U S A. 2017;114:E4048-E4056 pubmed publisher
    ..Interestingly, the transcription factor myocyte enhancer factor 2d (MEF2D) is known to be important in photoreceptor survival, as knockout of this transcription factor results in loss of ..
  56. Li L, Rubin L, Gong X. MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation. Physiol Genomics. 2018;50:10-19 pubmed publisher
    ..we show that members of the MEF2 family are differentially expressed in human placental CTBs, with MEF2B and MEF2D being highly expressed in first trimester extravillous CTBs...
  57. Katz Imberman S, Kolpakova A, Keren A, Bengal E. Myocyte enhancer factor 2D regulates ectoderm specification and adhesion properties of animal cap cells in the early Xenopus embryo. FEBS J. 2015;282:2930-47 pubmed publisher
    ..We find that Mef2D is required for the formation of both ectodermal lineages: neural and epidermis...
  58. Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey R, et al. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun. 2016;7:13331 pubmed publisher
    ..Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL)..
  59. Herglotz J, Unrau L, Hauschildt F, Fischer M, Kriebitzsch N, Alawi M, et al. Essential control of early B-cell development by Mef2 transcription factors. Blood. 2016;127:572-81 pubmed publisher
    ..We demonstrate that B-cell development is blocked at the pre-B-cell stage in mice deficient for Mef2c and Mef2d TFs and that pre-BCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ..
  60. Huang L, Deng M, He Y, Lu S, Liu S, Fang Y. β-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression. Behav Brain Res. 2016;313:370-379 pubmed publisher
    Inactive myocyte enhancer factor 2D (MEF2D) and alpha-synuclein (α-syn) aggregation will cause neuronal death...
  61. Zhang Q, Liao Y, Ji Z, Gu Y, Jiang H, Xie Z, et al. TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons. Exp Ther Med. 2016;12:2594-2598 pubmed
    ..the protective effects of TFP5, the expression levels of p35, p25 and phosphorylated myocyte enhancer factor 2 (p-MEF2D) were determined by western blotting...
  62. Xu H, Li J, Wang Z, Feng M, Shen Y, Cao S, et al. Methylene blue attenuates neuroinflammation after subarachnoid hemorrhage in rats through the Akt/GSK-3β/MEF2D signaling pathway. Brain Behav Immun. 2017;65:125-139 pubmed publisher
    ..MB administration also promoted the phosphorylation of Akt and GSK-3β, leading to an increased concentration of MEF2D in the nucleus...
  63. van den Hoogenhof M, van der Made I, Beqqali A, de Groot N, Damanafshan A, van Oort R, et al. The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice. PLoS ONE. 2017;12:e0184093 pubmed publisher
    ..We found that stability targets p21 and HuR, splicing targets Mef2d and Fgfr2, and translation target p53 were not altered, suggesting that these Rbm38 targets are tissue-specific or ..
  64. Choi S, Park S, Han T. 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. Nucleic Acids Res. 2001;29:2836-42 pubmed
    ..proteins belong to the MADS box family of transcription factors and four MEF2 proteins, MEF2A, MEF2B, MEF2C and MEF2D, have been found...
  65. Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, et al. Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. Leukemia. 2005;19:806-13 pubmed
    ..the t(1;19) in TS-2 fuses the 19p13 gene DAZAP1 (Deleted in Azoospermia-Associated Protein 1) to the 1q23 gene MEF2D (Myocyte Enhancer Factor 2D), leading to expression of reciprocal in-frame DAZAP1/MEF2D and MEF2D/DAZAP1 ..
  66. Du M, Perry R, Nowacki N, Gordon J, Salma J, Zhao J, et al. Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D. Mol Cell Biol. 2008;28:2952-70 pubmed publisher
    ..MEF2, and subsequent analysis by in vitro kinase assays indicated that PKA directly and efficiently phosphorylates MEF2D. Using mass spectrometric determination of phosphorylated residues, we document that MEF2D serine 121 and serine ..
  67. Aude Garcia C, Collin Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C. Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression. Biochem J. 2010;430:237-44 pubmed publisher
    ..We show in the present study that MEF2A and MEF2D, two other MEF2 family members, are expressed in human primary monocytes and in higher amounts in monocyte-derived ..
  68. Xu K, Zhao Y. MEF2D/Wnt/β-catenin pathway regulates the proliferation of gastric cancer cells and is regulated by microRNA-19. Tumour Biol. 2016;37:9059-69 pubmed publisher
    ..The transcription factor myocyte enhancer factor 2D (MEF2D) participates in the initiation and development of many human cancers...
  69. Li G, Zhao G, Yang J, Zhou Y, Yang K, Lei Y, et al. Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression. Oncol Rep. 2017;37:3475-3483 pubmed publisher
    ..promoted caspase-3 activity and p53 and Bax protein expression, and suppressed myocyte enhancer factor 2D (MEF2D) and cyclin D1 protein expression in cisplatin‑treated A549 and NCI-H522 cells...
  70. Li Y, Zhang L, Nong J, Bian S, Zhao Z, Ren Y, et al. [Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;25:840-2, 847 pubmed
    To explore the expression of MEF2D in NPC tissues, study the relationship between the expression and prognostic...
  71. Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt G, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet. 2012;44:777-82 pubmed publisher
    ..SNPs at two of these loci showed convincing replication: at 1q22 (in MEF2D; replication P = 4.9 × 10(-4); combined P = 7.06 × 10(-11)) and at 3p24 (near TGFBR2; replication P = 1...
  72. Zhang R, Zhang Y, Li H. miR-1244/Myocyte Enhancer Factor 2D Regulatory Loop Contributes to the Growth of Lung Carcinoma. DNA Cell Biol. 2015;34:692-700 pubmed publisher
    ..miR-1244 was then verified to negatively regulate the expression of myocyte enhancer factor 2D (MEF2D) in lung cancer cells. MEF2D can also affect the expression of miR-1244 by directly binding to its promoter...
  73. Zhang J, Guo F, Wei J, Xian M, Tang S, Zhao Y, et al. An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection. Free Radic Biol Med. 2017;112:480-493 pubmed publisher
    ..transcription activity of DNA-(apurinic or apyrimidinic site) lyase (Apex1), Myocyte-specific enhancer factor 2D (Mef2d) and Pre B-cell leukemia transcription factor 3 (Pbx3) was further verified in pluripotent stem cell-derived ..
  74. Hong X, Hong X, Li T, He C. Pokemon and MEF2D co-operationally promote invasion of hepatocellular carcinoma. Tumour Biol. 2015;36:9885-93 pubmed publisher
    ..Pokemon overexpression was able to enhance the invasion of MHCC-97L cells with lower invasiveness. MEF2D, an oncogene promoting the invasion of HCC cells, was further detected to be upregulated and downregulated when ..
  75. Ornatsky O, McDermott J. MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells. J Biol Chem. 1996;271:24927-33 pubmed
    ..By immunofluorescence, we detected abundant nuclear localized MEF2A and MEF2D protein expression in HeLa cells and C2C12 muscle cells...
  76. Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, et al. Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. J Biol Chem. 2000;275:18534-40 pubmed
    ..Here, we demonstrate that, in addition to MEF2C, BMK1 phosphorylates and activates MEF2A and MEF2D but not MEF2B...
  77. Zhao X, Sternsdorf T, Bolger T, Evans R, Yao T. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005;25:8456-64 pubmed
    ..Our studies reveal a novel regulation of MEF2 transcriptional activity by two distinct classes of deacetylases that affect MEF2 sumoylation and acetylation. ..
  78. Cao Q, Dong P, Wang Y, Zhang J, Shi X, Wang Y. miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. Oncol Rep. 2015;33:2606-12 pubmed publisher
    ..In the present study, we found that the level of myocyte enhancer factor 2D (MEF2D), a key regulatory protein for cardiac development, was elevated in specimens of cardiac myxoma, and was ..
  79. Yasuda T, Hayakawa F. Acute lymphoblastic leukemia of adolescents and young adults: from the viewpoint of physicians. Rinsho Ketsueki. 2017;58:1031-1037 pubmed publisher
    ..5%) and was preferentially detected in the AYA generation. ZNF384 and MEF2D genes were also recurrently identified as functionally relevant fusion genes in 16.7% and 9...
  80. Glubb D, Johnatty S, Quinn M, O Mara T, Tyrer J, Gao B, et al. Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci. Oncotarget. 2017;8:64670-64684 pubmed publisher
    ..Bioinformatic and functional genetic analyses indicated that MEF2D and ZNF100 are targets of candidate outcome variants at 1q22 and 19p12, respectively...
  81. Dacwag C, Bedford M, SIF S, Imbalzano A. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009;29:1909-21 pubmed publisher
    ..Thus, distinct arginine methyltransferases are employed at different times of skeletal muscle differentiation for the purpose of facilitating ATP-dependent chromatin-remodeling enzyme interaction and function at myogenic genes. ..
  82. Zhu H, Shi L, Zhang Y, Zhu Y, Bai C, Wang X, et al. Myocyte enhancer factor 2D provides a cross-talk between chronic inflammation and lung cancer. J Transl Med. 2017;15:65 pubmed publisher
    ..of the 16 enrolled GSE datasets from Gene Expression Omnibus online database showed myocyte enhancer factor 2D (MEF2D) level significantly increased in COPD patients coexisting non-small-cell lung carcinoma (NSCLC)...
  83. Guo B, Hu S, Zheng C, Wang H, Luo F, Li H, et al. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017;126:12-24 pubmed publisher PC12 cells was achieved through the activation of transcription factor myocyte enhancer factor 2D (MEF2D), as evidenced by the fact that SU4312 stimulated myocyte enhancer factor 2 (MEF2) transcriptional activity and ..
  84. Zhao M, New L, Kravchenko V, Kato Y, Gram H, Di Padova F, et al. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol. 1999;19:21-30 pubmed
    ..We found that MEF2A, but not MEF2B or MEF2D, is a substrate for p38. Among the four p38 group members, p38 is the most potent kinase for MEF2A...
  85. Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M. MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem. 2005;280:32272-8 pubmed
    ..These findings identify a novel mechanism for HAND action in the heart and provide a general paradigm to understand the mechanism of HAND action in organogenesis. ..
  86. Choi J, Jang H, Kim H, Kim S, Cho E, Youn H. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun. 2010;401:327-32 pubmed publisher
    ..Altogether, the present study suggests a de-repression model and expands the understanding on the dynamic regulation of chromatin during myogenesis...
  87. Huo Y, Zhao Q, Wang C, Zhao F, Du Y, Sun W. The involvement of myocyte enhancer factor 2D in regulating tumor biology of cardiac myxoma. Tumour Biol. 2016;37:5405-11 pubmed publisher
    The pro-survival transcription factor myocyte enhancer factor 2D (MEF2D) is identified to exhibit pro-tumor effects based on clinical and experimental studies...
  88. Kong J, Liu X, Li X, Wu J, Wu N, Chen J, et al. Pokemon promotes the invasiveness of hepatocellular carcinoma by enhancing MEF2D transcription. Hepatol Int. 2016;10:493-500 pubmed publisher
    ..Myocyte enhancer factor 2D (MEF2D), an oncogene that can promote the invasiveness of HCC, was found to be underexpressed during Pokemon silencing in ..
  89. Okamoto S, Li Z, Ju C, Scholzke M, Mathews E, Cui J, et al. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002;99:3974-9 pubmed
    ..Additionally, we show that similar MEF2 cleavage fragments are generated in vivo during focal stroke damage. Hence, this pathway appears to have pathophysiological relevance in vivo. ..
  90. Gregoire S, Tremblay A, Xiao L, Yang Q, Ma K, Nie J, et al. Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J Biol Chem. 2006;281:4423-33 pubmed
    ..We recently showed that human MEF2D (myocyte enhancer factor 2D) is sumoylated on Lys-439...
  91. Yang C, Ornatsky O, McDermott J, Cruz T, Prody C. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Nucleic Acids Res. 1998;26:4771-7 pubmed
    ..Furthermore, when cotransfected with ERK5/BMK1, the transactivation capacity of MEF2 was enhanced. These results suggest that the functions of MEF2 could be regulated through ERK5/BMK1. ..
  92. Youn H, Sun L, Prywes R, Liu J. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science. 1999;286:790-3 pubmed
    ..The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis. ..