MEF2B

Summary

Gene Symbol: MEF2B
Description: myocyte enhancer factor 2B
Summary: This gene represents numerous read-through transcripts that span geneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on geneID:100271849. [provided by RefSeq]
Alias: FLJ32599, FLJ46391, MGC189732, MGC189763, RSRFR2, MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)
Species: human
Products:     MEF2B antibody    MEF2B chemical    MEF2B cDNA    MEF2B ELISA    MEF2B protein    MEF2B siRNA    MEF2B other

Webpages

  1. how to make antibodies using genetic immunization
    pga.swmed.edu/Education/how_to_make_antibodies_info.htm

Publications

  1. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
    Y T Yu
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts
    Genes Dev 6:1783-98
  2. Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression
    Xiaoming Gong
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and Brown Medical School, Providence, Rhode Island, USA
    BMC Mol Biol 7:7
  3. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2
    Aidong Han
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309 0215, USA
    J Mol Biol 345:91-102
  4. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2
    Aidong Han
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309 0215, USA
    Nature 422:730-4
  5. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons
    M Li
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 21:6544-52
  6. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2
    H D Youn
    Center for Cancer Research, Department of Biology, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 286:790-3
  7. Expression of MEF2 genes during human cardiac development
    K Iida
    Department of Bioscience, National Cardiovascular Center, Suita, Osaka, Japan
    Tohoku J Exp Med 187:15-23
  8. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression
    Y Katoh
    Section of Molecular Cardiology, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 273:1511-8
  9. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23
    G M Hobson
    Department of Medical Cell Biology, Alfred I duPont Institute, Wilmington, Delaware 19899, USA
    Genomics 29:704-11
  10. Human SRF-related proteins: DNA-binding properties and potential regulatory targets
    R Pollock
    Transcription Laboratory, Imperial Cancer Research Fund Laboratories, London, UK
    Genes Dev 5:2327-41

Scientific Experts

  • Stéphane Konig
  • Xiaoming Gong
  • Stephanie Bechtel
  • Aidong Han
  • Jun O Liu
  • Lin Chen
  • M Li
  • K Iida
  • H D Youn
  • Y Katoh
  • Yongqing Wu
  • Ju He
  • Fan Pan
  • James C Stroud
  • Hong Duk Youn
  • Hong-Duk Youn
  • D A Linseman
  • X Wang
  • M K Meintzer
  • M E Wierman
  • K A Heidenreich
  • M P Allen
  • T Laessig
  • G M Hobson
  • M Nakayama
  • T Mukai
  • K Hidaka
  • L Sun
  • J O Liu
  • M Takeuchi
  • C Yutani
  • T Morisaki
  • R Prywes
  • V Dave
  • M Periasamy
  • J D Molkentin
  • E N Olson
  • E Garcia
  • V L Funanage
  • R Krahe
  • M J Siciliano
  • Y T Yu
  • V Mahdavi
  • L B Smoot
  • R E Breitbart
  • R Pollock
  • B Nadal Ginard
  • Y Lee
  • B Nadal-Ginard
  • R Treisman

Detail Information

Publications12

  1. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
    Y T Yu
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts
    Genes Dev 6:1783-98
    ..Moreover, MEF2 is induced in nonmuscle cells by MyoD; however, MEF2 alone is insufficient to produce the full muscle phenotype. Implications for the molecular mechanisms of myogenesis are considered...
  2. Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression
    Xiaoming Gong
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and Brown Medical School, Providence, Rhode Island, USA
    BMC Mol Biol 7:7
    ..The findings suggest that the interaction between MEF2 and PPAR factors may provide a molecular basis for interspecies differences in the transcriptional regulation of the BCMO1 gene...
  3. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2
    Aidong Han
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309 0215, USA
    J Mol Biol 345:91-102
    ..have characterized the complex between the MEF2-binding motif of class II HDACs and the MADS-box/MEF2S domain of MEF2B by structural and biochemical methods...
  4. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2
    Aidong Han
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309 0215, USA
    Nature 422:730-4
    ..Here we report a crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution...
  5. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons
    M Li
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 21:6544-52
    ..Endogenous MEF2A and MEF2D, but not MEF2B or MEF2C, were phosphorylated with the induction of apoptosis...
  6. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2
    H D Youn
    Center for Cancer Research, Department of Biology, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 286:790-3
    ..The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis...
  7. Expression of MEF2 genes during human cardiac development
    K Iida
    Department of Bioscience, National Cardiovascular Center, Suita, Osaka, Japan
    Tohoku J Exp Med 187:15-23
    ..Expression of all four MEF2 transcripts (MEF2A, MEF2B, MEF2C, and MEF2D) were detected in all developmental stage of the human heart, while Mef2b transcripts were down-..
  8. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression
    Y Katoh
    Section of Molecular Cardiology, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 273:1511-8
    ..We also demonstrate that the protein complex obtained from smooth muscle nuclear extract reacts with MEF2B-specific antibody, but not with antibodies specific to MEF2A, MEF2C, or MEF2D, suggesting that only MEF2B protein ..
  9. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23
    G M Hobson
    Department of Medical Cell Biology, Alfred I duPont Institute, Wilmington, Delaware 19899, USA
    Genomics 29:704-11
    ..YAC clones for two of the genes, MEF2A and MEF2C, and a PCR product was used to identify cosmid clones for MEF2B. Genetic and physical mapping information available from genome databases on markers contained within YAC and ..
  10. Human SRF-related proteins: DNA-binding properties and potential regulatory targets
    R Pollock
    Transcription Laboratory, Imperial Cancer Research Fund Laboratories, London, UK
    Genes Dev 5:2327-41
    ..related to the SRF DNA-binding domain: In RSRFC4 and RSRFC9, this region is identical, whereas that present in RSRFR2 differs by seven conservative amino acid substitutions...
  11. The full-ORF clone resource of the German cDNA Consortium
    Stephanie Bechtel
    Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Genomics 8:399
    ....