Gene Symbol: MEF2B
Description: myocyte enhancer factor 2B
Alias: RSRFR2, myocyte-specific enhancer factor 2B, MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), serum response factor-like protein 2
Species: human
Products:     MEF2B

Top Publications

  1. Youn H, Sun L, Prywes R, Liu J. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science. 1999;286:790-3 pubmed
    ..The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis. ..
  2. Han A, Pan F, Stroud J, Youn H, Liu J, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature. 2003;422:730-4 pubmed
    ..Here we report a crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution...
  3. Morin R, Mendez Lago M, Mungall A, Goya R, Mungall K, Corbett R, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011;476:298-303 pubmed publisher
    ..4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones...
  4. Han A, He J, Wu Y, Liu J, Chen L. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J Mol Biol. 2005;345:91-102 pubmed
    ..have characterized the complex between the MEF2-binding motif of class II HDACs and the MADS-box/MEF2S domain of MEF2B by structural and biochemical methods...
  5. Tempera I, De Leo A, Kossenkov A, Cesaroni M, Song H, Dawany N, et al. Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival. J Virol. 2016;90:345-55 pubmed publisher
    ..EBNA1 bound to genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1...
  6. Han T, Prywes R. Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol. 1995;15:2907-15 pubmed
    ..This is the domain homologous to that in the serum response factor which is required for serum induction of the c-fos serum response element, suggesting that serum regulation of c-fos and c-jun may share a common mechanism. ..
  7. Katoh Y, Molkentin J, Dave V, Olson E, Periasamy M. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. J Biol Chem. 1998;273:1511-8 pubmed
    ..We also demonstrate that the protein complex obtained from smooth muscle nuclear extract reacts with MEF2B-specific antibody, but not with antibodies specific to MEF2A, MEF2C, or MEF2D, suggesting that only MEF2B protein ..
  8. Li M, Linseman D, Allen M, Meintzer M, Wang X, Laessig T, et al. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J Neurosci. 2001;21:6544-52 pubmed
    ..Endogenous MEF2A and MEF2D, but not MEF2B or MEF2C, were phosphorylated with the induction of apoptosis...
  9. Liu G, Han J, Profirovic J, Strekalova E, Voyno Yasenetskaya T. Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Angiogenesis. 2009;12:1-15 pubmed publisher
    ..Our studies suggest that MEF2 proteins are an important component in Galpha13-mediated angiogenesis. ..

More Information


  1. Pollock R, Treisman R. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 1991;5:2327-41 pubmed
    ..related to the SRF DNA-binding domain: In RSRFC4 and RSRFC9, this region is identical, whereas that present in RSRFR2 differs by seven conservative amino acid substitutions...
  2. Pon J, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng S, et al. MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nat Commun. 2015;6:7953 pubmed publisher
    Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL)...
  3. Ying C, Dominguez Sola D, Fabi M, Lorenz I, Hussein S, Bansal M, et al. MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol. 2013;14:1084-92 pubmed publisher
    b>MEF2B encodes a transcriptional activator and is mutated in ?11% of diffuse large B cell lymphomas (DLBCLs) and ?12% of follicular lymphomas (FLs)...
  4. Sun Q, Sattayakhom A, Backs J, Stremmel W, Chamulitrat W. Role of myocyte enhancing factor 2B in epithelial myofibroblast transition of human gingival keratinocytes. Exp Biol Med (Maywood). 2012;237:178-85 pubmed publisher
    ..Myocyte enhancing factor 2B (MEF2B) is the only MEF2 isoform expressed during early embryonic development, and is herein proposed to transactivate ..
  5. Guo X. [Properties comparing and evolutionary analysis of MEF2 of Homo sapiens based on bioinformatic methods]. Yi Chuan. 2011;33:975-81 pubmed
    ..The phylogenetic tree result shows that MEF2B may be original because of its difference of sequences and evolutional relation.
  6. Bechtel S, Rosenfelder H, Duda A, Schmidt C, Ernst U, Wellenreuther R, et al. The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007;8:399 pubmed publisher
  7. Gong X, Tsai S, Yan B, Rubin L. Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression. BMC Mol Biol. 2006;7:7 pubmed
    ..The findings suggest that the interaction between MEF2 and PPAR factors may provide a molecular basis for interspecies differences in the transcriptional regulation of the BCMO1 gene. ..
  8. Konig S, Hinard V, Arnaudeau S, Holzer N, Potter G, Bader C, et al. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. J Biol Chem. 2004;279:28187-96 pubmed
    ..We propose that Kir2.1 channel activation is a required key early event that initiates myogenesis by turning on myogenin and MEF2 transcription factors via a hyperpolarization-activated Ca(2+)-dependent pathway. ..
  9. Karasseva N, Tsika G, Ji J, Zhang A, Mao X, Tsika R. Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Mol Cell Biol. 2003;23:5143-64 pubmed
  10. Hobson G, Krahe R, Garcia E, Siciliano M, Funanage V. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. Genomics. 1995;29:704-11 pubmed
    ..YAC clones for two of the genes, MEF2A and MEF2C, and a PCR product was used to identify cosmid clones for MEF2B. Genetic and physical mapping information available from genome databases on markers contained within YAC and ..
  11. Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, et al. Expression of MEF2 genes during human cardiac development. Tohoku J Exp Med. 1999;187:15-23 pubmed
    ..Expression of all four MEF2 transcripts (MEF2A, MEF2B, MEF2C, and MEF2D) were detected in all developmental stage of the human heart, while Mef2b transcripts were down-..
  12. Krenács D, Borbényi Z, Bedekovics J, Méhes G, Bagdi E, Krenács L. Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas. Virchows Arch. 2015;467:345-55 pubmed publisher
    Myocyte enhancer binding factor 2 B (MEF2B) is a member of the evolutionary conserved transcription family MEF2...
  13. Yu Y, Breitbart R, Smoot L, Lee Y, Mahdavi V, Nadal Ginard B. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 1992;6:1783-98 pubmed
    ..Moreover, MEF2 is induced in nonmuscle cells by MyoD; however, MEF2 alone is insufficient to produce the full muscle phenotype. Implications for the molecular mechanisms of myogenesis are considered. ..
  14. Moore E, Swerdlow S, Gibson S. J chain and myocyte enhancer factor 2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Hum Pathol. 2017;68:47-53 pubmed publisher
    ..We investigated the utility of J chain and myocyte enhancer factor 2B (MEF2B) in the diagnosis of CHL; NLPHL; PMBL; T-cell/histiocyte-rich large B-cell lymphoma (TCRLBL); and B-cell lymphoma, ..