MEF2A

Summary

Gene Symbol: MEF2A
Description: myocyte enhancer factor 2A
Alias: ADCAD1, RSRFC4, RSRFC9, mef2, myocyte-specific enhancer factor 2A, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), serum response factor-like protein 1
Species: human
Products:     MEF2A

Top Publications

  1. Zhao M, New L, Kravchenko V, Kato Y, Gram H, Di Padova F, et al. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol. 1999;19:21-30 pubmed
    ..We found that MEF2A, but not MEF2B or MEF2D, is a substrate for p38...
  2. Weng L, Kavaslar N, Ustaszewska A, Doelle H, Schackwitz W, Hebert S, et al. Lack of MEF2A mutations in coronary artery disease. J Clin Invest. 2005;115:1016-20 pubmed
    Mutations in MEF2A have been implicated in an autosomal dominant form of coronary artery disease (adCAD1)...
  3. Riquelme C, Barthel K, Liu X. SUMO-1 modification of MEF2A regulates its transcriptional activity. J Cell Mol Med. 2006;10:132-44 pubmed
    ..In this study, we demonstrate that MEF2A undergoes sumoylation primarily at a single lysine residue (K395) both in vitro and in vivo...
  4. Gulec S, Ruchan Akar A, Akar N. MEF2A sequence variants in Turkish population. Clin Appl Thromb Hemost. 2008;14:465-7 pubmed
    Myocyte enhancer factor 2 (MEF2) is present in skeletal, cardiac, and smooth muscles and in neurons. MEF2A gene encodes a transcription factor which was on 15q26. The objective was to study the MEF2A gene in patients with premature MI...
  5. Dai D, Zhou X, Xiao Y, Xu F, Sun F, Ji F, et al. Structural changes in exon 11 of MEF2A are not related to sporadic coronary artery disease in Han Chinese population. Eur J Clin Invest. 2010;40:669-77 pubmed publisher
    A mutation in MEF2A (myocyte enhancer factor-2A) had been reported to be the first gene linked directly to coronary artery disease (CAD)...
  6. Altshuler D, Hirschhorn J. MEF2A sequence variants and coronary artery disease: a change of heart?. J Clin Invest. 2005;115:831-3 pubmed
    Rare mutations in MEF2A have been proposed as a cause of coronary artery disease (CAD) and myocardial infarction (MI)...
  7. Shalizi A, Gaudilliere B, Yuan Z, Stegmuller J, Shirogane T, Ge Q, et al. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science. 2006;311:1012-7 pubmed
    ..We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex...
  8. Bhagavatula M, Fan C, Shen G, Cassano J, Plow E, Topol E, et al. Transcription factor MEF2A mutations in patients with coronary artery disease. Hum Mol Genet. 2004;13:3181-8 pubmed
    ..We recently discovered that a seven-amino acid deletion in MEF2A, a transcription factor with a high level of expression in the endothelium of coronary arteries, co-segregates ..
  9. Kajimoto K, Shioji K, Tago N, Tomoike H, Nonogi H, Goto Y, et al. Assessment of MEF2A mutations in myocardial infarction in Japanese patients. Circ J. 2005;69:1192-5 pubmed
    Recently, a mutation in the human MEF2A gene was reported to be responsible for an autosomal dominant form of coronary artery disease, so the purpose of the present study was to assess the significance of MEF2A mutations in Japanese ..

More Information

Publications179 found, 100 shown here

  1. Hsu L, Chang C, Teng M, Semon Wu -, Hu C, Chang W, et al. CAG repeat polymorphism of the MEF2A gene is not associated with the risk of coronary artery disease among Taiwanese. Clin Appl Thromb Hemost. 2010;16:301-5 pubmed publisher
    A 21-bp deletion mutation of the exon 11 of the myocyte enhancer factor-2A (MEF2A) gene was shown to cause familial coronary artery disease...
  2. Guella I, Rimoldi V, Asselta R, Ardissino D, Francolini M, Martinelli N, et al. Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease. Circ Cardiovasc Genet. 2009;2:165-72 pubmed publisher
    Mutations in the MEF2A gene, coding for a member of the myocyte enhancer factor 2 family of transcription factors, have been reported in patients with coronary artery disease and myocardial infarction (MI)...
  3. Han Y, Yang Y, Zhang X, Yan C, Xi S, Kang J. Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population. Clin Chem Lab Med. 2007;45:987-92 pubmed
    Recently, a mutation in the human myocyte enhancer factor-2A (MEF2A) gene was reported to be responsible for an autosomal dominant form of coronary artery disease (CAD)...
  4. Wang L, Fan C, Topol S, Topol E, Wang Q. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science. 2003;302:1578-81 pubmed
    ..Here, we describe an autosomal dominant form of CAD/MI (adCAD1) that is caused by the deletion of seven amino acids in transcription factor MEF2A...
  5. Li J, Yang J, Li W, Du R, Gui L, Tian L, et al. [Study on novel mutations of MEF2A gene in Chinese patients with coronary artery disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23:265-8 pubmed
    To explore the mutations of MEF2A gene in Chinese patients with coronary artery disease(CAD)...
  6. Horan P, Allen A, Hughes A, Patterson C, Spence M, McGlinchey P, et al. Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study. BMC Med Genet. 2006;7:65 pubmed
    ..Mutations in the MEF2A gene have recently been reported in patients with IHD...
  7. Ornatsky O, McDermott J. MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells. J Biol Chem. 1996;271:24927-33 pubmed
    ..By immunofluorescence, we detected abundant nuclear localized MEF2A and MEF2D protein expression in HeLa cells and C2C12 muscle cells...
  8. Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, et al. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron. 2003;38:33-46 pubmed
    ..We have identified the prosurvival transcription factor MEF2 as a direct nuclear target of Cdk5...
  9. Gonzalez P, Garcia Castro M, Reguero J, Batalla A, Ordóñez A, Palop R, et al. The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction. J Med Genet. 2006;43:167-9 pubmed
    A myocyte enhancer factor 2A (MEF2A) mutation that segregated with coronary artery disease/myocardial infarction (CAD/MI) in a large family has recently been described...
  10. Yuan H, Lu H, Hu J, Chen S, Yang G, Huang Z. MEF2A gene and susceptibility to coronary artery disease in the Chinese people. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31:453-7 pubmed
    To explore MEF2A gene and susceptibility to coronary artery disease in the Chinese...
  11. Chakraborty S, Reineke E, Lam M, Li X, Liu Y, Gao C, et al. Alpha-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7. J Biol Chem. 2006;281:35070-80 pubmed
    ..A point mutation in HDAC7 that disrupts its association with MEF2A also disrupts its association with alpha-actinin 4, indicating that MEF2A and alpha-actinin 4 binding sites ..
  12. Lieb W, Mayer B, Konig I, Borwitzky I, Götz A, Kain S, et al. Lack of association between the MEF2A gene and myocardial infarction. Circulation. 2008;117:185-91 pubmed
    Coronary artery disease (CAD) and myocardial infarction (MI) are caused in part by genetic factors. Recently, the MEF2A gene was linked to MI/CAD in a single pedigree with autosomal-dominant pattern of inheritance...
  13. Elhawari S, Al Boudari O, Muiya P, Khalak H, Andres E, Al Shahid M, et al. A study of the role of the Myocyte-specific Enhancer Factor-2A gene in coronary artery disease. Atherosclerosis. 2010;209:152-4 pubmed publisher
    We evaluated the role of the MEF2A as a risk factor for coronary artery disease (CAD) in 1186 subjects with angiographically documented disease compared with 885 CAD-free individuals in the Saudi population...
  14. Neely M, Robert E, Baucum A, Colbran R, Muly E, Deutch A. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res. 2009;1274:55-65 pubmed publisher
    ..We have analyzed the regional, cellular, and subcellular expression of MEF2A and MEF2D in the rodent brain...
  15. Medrano J, Naya F. The transcription factor MEF2A fine-tunes gene expression in the atrial and ventricular chambers of the adult heart. J Biol Chem. 2017;292:20975-20988 pubmed publisher
    ..To better understand the mechanisms of MEF2-mediated regional gene regulation in the heart, we took advantage of MEF2A knock-out (KO) mice, a model that displays a predominantly ventricular chamber phenotype...
  16. Rodríguez Tornos F, San Aniceto I, Cubelos B, Nieto M. Enrichment of conserved synaptic activity-responsive element in neuronal genes predicts a coordinated response of MEF2, CREB and SRF. PLoS ONE. 2013;8:e53848 pubmed publisher
    A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity...
  17. Ichihara M, Kamiya T, Hara H, Adachi T. The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or p300 in SOD3 expression in THP-1 cells. Free Radic Res. 2018;52:799-807 pubmed publisher
    ..The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300...
  18. Hu H, Li L, Wang C, He H, Mao K, Ma X, et al. 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33:1899-910 pubmed
    ..This increased the binding of MEF2A to the site on the GLUT4 promoter, resulting in increased GLUT4 expression...
  19. Moraes P, Yonamine C, Pinto Junior D, Esteves J, Machado U, Mori R. Insulin acutely triggers transcription of Slc2a4 gene: participation of the AT-rich, E-box and NFKB-binding sites. Life Sci. 2014;114:36-44 pubmed publisher
    ..repressor), and processed for analysis of GLUT4 protein (Western blotting); Slc2a4, myocyte enhancer factor 2a/d (Mef2a/d), hypoxia inducible factor 1a (Hif1a), myogenic differentiation 1 (Myod1) and nuclear factor of kappa light ..
  20. Wu Y, Yang J, Ai Z, Yu M, Li J, Li S. Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. Gene. 2019;692:79-87 pubmed publisher
    ..11 TFs (CREB1, CUX1, EGR1, EP300, FOXC1, HSF2, MEF2A, PLAU, SP1, STAT1 and USF1) for DEGs were predicted and 2 highly scored co-expression relationships (EP300-PPP2R1A ..
  21. Lobanok E, Kvacheva Z, Pinchuk S, Volk M, Mezhevkina L, Fesenko E, et al. [The influence of fibroblast growth factor (FGF2) on cardiomyocytes differentiation of mesenchymal stem cells of bone marrow ex vivo]. Biofizika. 2014;59:360-8 pubmed
    ..14th day after the combined action of a differentiating agent and growth factor was manifested in an increase in Mef2A, Mef2D and gene transcription and a rise of ionized Ca2+ concentration in cytoplasm keeping cell viability and ..
  22. Huang Y, Wu X, Guo J, Yuan J. Myocyte-specific enhancer binding factor 2A expression is downregulated during temporal lobe epilepsy. Int J Neurosci. 2016;126:786-96 pubmed publisher
    Myocyte-specific enhancer binding factor 2A (MEF2A) is a multifunctional nuclear protein that regulates synaptogenesis, dendritic morphogenesis, and neuronal survival...
  23. Schiaffino S, Dyar K, Calabria E. Skeletal muscle mass is controlled by the MRF4-MEF2 axis. Curr Opin Clin Nutr Metab Care. 2018;21:164-167 pubmed publisher
    ..growth is supported by the finding that muscle regeneration is impaired by muscle-specific triple knockout of Mef2a, c, and d genes...
  24. Chang C, Singh A, Gross M, Kioussi C. Requirement of Pitx2 for skeletal muscle homeostasis. Dev Biol. 2019;445:90-102 pubmed publisher
    ..excision was limited to fetal muscle fibers after the G1-G0 transition and resulted in altered MHC, Rac1, MEF2a, and alpha-tubulin expression within these fibers...
  25. Andzelm M, Vanness D, Greenberg M, Linden D. A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Cell Rep. 2019;26:1089-1097.e3 pubmed publisher
    ..The late phase of LTD is also completely blocked in Purkinje cells derived from MEF2A+MEF2D null mice and rescued with plasmids that drive expression of MEF2D but not phosphatase-resistant mutant ..
  26. Rizzo M, Beffy P, Del Carratore R, Falleni A, Pretini V, D Aurizio R, et al. Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts. Cell Death Dis. 2018;9:1071 pubmed publisher
    ..profiles revealed that CDM15 myoblasts failed to upregulate the complex network of myo-miRNAs under MYOD and MEF2A control, while this network was upregulated in CDM13 myoblasts...
  27. Ustiugova A, Korneev K, Kuprash D, Afanasyeva A. Functional SNPs in the Human Autoimmunity-Associated Locus 17q12-21. Genes (Basel). 2019;10: pubmed publisher
    ..The strongest effect visible in three distinct cell types was observed for rs12946510 that is predicted to alter MEF2A/C and FOXO1 binding sites.
  28. Lu H, Liu B, Zhang F, Zhang J, Dong R, Chen L, et al. The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation. Cell Cycle. 2014;13:3892-902 pubmed publisher
    Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation...
  29. Ayeleso T, Ramachela K, Mukwevho E. Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato (Ipomoeabatatas) Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in Insulin Resistant C2C12 Cells. Molecules. 2018;23: pubmed publisher
    ..glucose transporter 4 (glut4), Nuclear respiratory factor 1 (nrf1), Myocyte enhanced factor 2A (mef2a), Carnitine palmitoyltransferase 1 (cpt1) and Acetyl-CoA carboxylase 2 (acc2)...
  30. Tobin S, Yang D, Girgis J, Farahzad A, Blais A, McDermott J. Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy. J Cell Sci. 2016;129:4076-4090 pubmed
    ..Using MEF2A, c-Jun and Fra-1 chromatin immunoprecipitation sequencing (ChIP-seq) data and predicted AP-1 consensus motifs, we ..
  31. Joseph J, Ayeleso A, Mukwevho E. Exercise increases hyper-acetylation of histones on the Cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes. Biochem Biophys Res Commun. 2017;486:83-87 pubmed publisher
    ..In type-2 diabetes, critical genes are down-regulated such as those involved in glucose transport (GLUT4, MEF2A) and also oxidative phosphorylation (NRF-1 and its target genes)...
  32. Wen C, Jiang X, Ding L, Wang T, Zhou Y. Effects of dietary methionine on breast muscle growth, myogenic gene expression and IGF-I signaling in fast- and slow-growing broilers. Sci Rep. 2017;7:1924 pubmed publisher
    ..The HM diets increased mRNA levels of myogenic regulatory factors (MRF4, Myf5) and myocyte enhancer factor 2 (MEF2A and MEF2B) in the FG broilers, and increased MEF2A and decreased myostatin mRNA level in the SG broilers...
  33. Dionyssiou M, Nowacki N, Hashemi S, Zhao J, Kerr A, Tsushima R, et al. Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle. J Mol Cell Cardiol. 2013;54:35-44 pubmed publisher
    ..Pharmacological inhibition of GSK3β resulted in enhanced MEF2A/D expression and transcriptional activity in skeletal myoblasts and cardiac myocytes...
  34. Ryu H, Seo J, Jung Y, Kim S, Kim E, Jang S, et al. Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc. J Cell Sci. 2019;132: pubmed publisher
    ..i>Arc transcription by enhancing destabilization of mRNAs encoding various transcription factors, including Mef2a. Upf1 also binds to the Arc 3'UTR, resulting in suppression of translation...
  35. Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M. MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem. 2005;280:32272-8 pubmed
    ..Instead, HAND1 is recruited to the promoter via physical interaction with MEF2 proteins...
  36. Dirkx E, Gladka M, Philippen L, Armand A, Kinet V, Leptidis S, et al. Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013;15:1282-93 pubmed publisher
    ..Our results reveal that signalling cascades integrate with microRNAs to induce the expression of the bHLH transcription factor Hand2 in the postnatal mammalian myocardium with impact on embryonic gene programs in heart failure. ..
  37. Yonamine C, Alves Wagner A, Esteves J, Okamoto M, Corrêa Giannella M, Giannella Neto D, et al. Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control. Mol Cell Endocrinol. 2018;: pubmed publisher
    ..animals, tri-methylation at lysine 9 of histone 3 (H3K9me3) increased in the Slc2a4 enhancer segment, whereas MEF2A/D binding into this segment was reduced; all effects were reversed by respective treatments...
  38. Maiolino G, Colonna S, Zanchetta M, Pedon L, Seccia T, Cesari M, et al. Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family. Eur J Cardiovasc Prev Rehabil. 2011;18:557-60 pubmed publisher
    ..One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group...
  39. Lee S, Won J, Yang J, Lee J, Kim S, Lee E, et al. AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin. Sci Rep. 2015;5:16523 pubmed publisher
    ..Mechanistic analysis showed that AKAP6 promotes myogenin expression through myocyte enhancer factor 2A (MEF2A). Notably, myogenin increases AKAP6 expression as well...
  40. Zhu B, Ramachandran B, Gulick T. Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. J Biol Chem. 2005;280:28749-60 pubmed
    ..In vertebrate MEF2A, -C, and -D, a splice versus no-splice option gives forms that include or exclude a short domain that we designate ..
  41. Kain V, Kapadia B, Viswakarma N, Seshadri S, Prajapati B, Jena P, et al. Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Sci Rep. 2015;5:15197 pubmed publisher
    ..Mechanistic analysis revealed that PIMT differentially regulated the expression of GLUT4, MEF2A, PGC-1α and HDAC5 in cultured cells and skeletal muscle of Wistar rats...
  42. Maruta H, Yoshimura Y, Araki A, Kimoto M, Takahashi Y, Yamashita H. Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells. PLoS ONE. 2016;11:e0158055 pubmed publisher
    ..Furthermore, treated cells also showed increased gene and protein expression of myocyte enhancer factor 2A (MEF2A), which is a well-known transcription factor involved in the expression of myoglobin and GLUT4 genes...
  43. Wang F, Zhang X, Yan Y, Zhu X, Yu J, Ding Y, et al. FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma. Cancer Lett. 2017;388:85-95 pubmed publisher
    ..of miR-223, a metastasis promoting miRNA that is transcriptionally regulated by Myocyte enhancer factor (MEF2A)...
  44. Talkhabi M, Razavi S, Salari A. Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming. J Cell Commun Signal. 2017;11:193-204 pubmed publisher
    ..and intermediate proteins predicted some new transcriptional activators such as myocyte enhancer factor 2A (MEF2A) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), which may be required for ..
  45. Desjardins C, Naya F. Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors. J Biol Chem. 2017;292:10613-10629 pubmed publisher
    ..Knockdown of individual MEF2 proteins, MEF2A, -C, and -D, in primary neonatal cardiomyocytes resulted in radically distinct and opposite effects on cellular ..
  46. Mora S, Yang C, Ryder J, Boeglin D, Pessin J. The MEF2A and MEF2D isoforms are differentially regulated in muscle and adipose tissue during states of insulin deficiency. Endocrinology. 2001;142:1999-2004 pubmed
    ..that striated muscle GLUT4 gene expression decreased following streptozotocin-induced diabetes due to a loss of MEF2A transcription factor expression without any significant effect on the MEF2D isoform (Mora, S. and J. E...
  47. Jones M, Wilson S, Mullin B, Mead R, Dudbridge F, Watts G, et al. Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome. Fertil Steril. 2008;90:2298-303 pubmed publisher
    To investigate polymorphisms in postinsulin receptor signaling. To investigate PIK3R1, SLC2A4, SLC2A4RG, and MEF2A to determine whether these genes are associated with susceptibility to polycystic ovary syndrome (PCOS) or key phenotypic ..
  48. Liopeta K, Boubali S, Virgilio L, Thyphronitis G, Mavrothalassitis G, Dimitracopoulos G, et al. cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2. Mol Immunol. 2009;46:345-54 pubmed publisher
    ..These results suggest that the inhibitory effect of cAMP on IL-10 production by normal peripheral T lymphocytes is cell type and stimulus specific, exerted on multiple levels and involves MEF2 transcription factor.
  49. Clark A, Naya F. MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. J Biol Chem. 2015;290:23162-72 pubmed publisher
    ..demonstrated previously that microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A transcription factor in skeletal muscle regeneration...
  50. Chang C, Wilkerson J, Hale C, Gibson J, Huber K. Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D. elife. 2017;6: pubmed publisher
    ..required de novo transcription, but only silencing required the activity-dependent transcription factors MEF2A/D...
  51. Karasseva N, Tsika G, Ji J, Zhang A, Mao X, Tsika R. Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Mol Cell Biol. 2003;23:5143-64 pubmed
    ..Despite the GATA/MEF2-like homology of this element, we found binding of two unknown proteins that were antigenically distinct from GATA ..
  52. Wu R, Wang J, Yao J, Dong Z, Liu Y, Liu M. MEF2A regulates Calpain 3 expression in L6 myoblasts. Gene. 2018;: pubmed publisher
    ..In the present study, we provided experimental data showing that the myogenic enhancer factor 2A (MEF2A) regulated Capn3 gene expression...
  53. Guo X, Zhang Q, Li M, Gao P, Cao G, Cheng Z, et al. Novel alternatively spliced isoforms of MEF2A and their mRNA expression patterns in pigs. J Genet. 2018;97:977-985 pubmed
    The present study aimed to identify the alternatively spliced isoforms of pig MEF2A gene and to determine theirmRNA expression patterns. Four alternatively spliced isoforms of pig MEF2A gene (i.e...
  54. Nammo T, Udagawa H, Funahashi N, Kawaguchi M, Uebanso T, Hiramoto M, et al. Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice. Diabetologia. 2018;61:2608-2620 pubmed publisher
    ..for nuclear respiratory factor 1 (NRF1), GA repeat binding protein α (GABPA) and myocyte enhancer factor 2A (MEF2A) by de novo motif analysis, whereas decreased H3K27ac was enriched for v-maf musculoaponeurotic fibrosarcoma ..
  55. Talari M, Kapadia B, Kain V, Seshadri S, Prajapati B, Rajput P, et al. MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts. Biochimie. 2015;119:16-26 pubmed publisher
    ..of miR-16 enhanced insulin stimulated glucose uptake in skeletal myoblasts via the up-regulation of GLUT4 and MEF2A, two key players involved in insulin stimulated glucose uptake...
  56. Chen W, Xu H, Chen X, Liu Z, Zhang W, Xia D. Functional and Activity Analysis of Cattle UCP3 Promoter with MRFs-Related Factors. Int J Mol Sci. 2016;17: pubmed publisher
    ..with muscle-related transcription factor myogenic regulatory factors (MRFs) and myocyte-specific enhancer factor 2A (MEF2A). We found that UCP3 promoter could be upregulated by Myf5, Myf6 and MyoD and downregulated by MyoG and MEF2A.
  57. Lv F, Zhu C, Yan X, Wang X, Liu D. Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Fish Physiol Biochem. 2017;43:287-294 pubmed publisher
    Transgenesis is an important tool for exploring gene expression and function. The myocyte enhancer factor 2a (mef2a) gene encodes a member of the Mef2 protein family that is involved in vertebrate skeletal, cardiac, and smooth muscle ..
  58. Maeda T, Gupta M, Stewart A. TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters. Biochem Biophys Res Commun. 2002;294:791-7 pubmed
    ..regulated by transcriptional enhancer factor-1 (TEF-1), serum response factor (SRF), and myocyte enhancer factor-2 (MEF2) transcription factors...
  59. Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, et al. Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol. 2010;397:520-33 pubmed publisher
    ..Here we present the crystal structure of the MADS-box/MEF2 domain of MEF2A bound to DNA...
  60. Vargas M, Tirnauer J, Glidden N, Kapiloff M, Dodge Kafka K. Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation. Cell Signal. 2012;24:1496-503 pubmed publisher
    ..The myocyte enhancer factor 2 (MEF2) transcription factors are critical to this process, synergizing with the master regulator MyoD to promote muscle ..
  61. Mizukoshi Y, Takeuchi K, Arutaki M, Tokunaga Y, Takizawa T, Hanzawa H, et al. Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State. Angew Chem Int Ed Engl. 2016;55:14606-14609 pubmed publisher
    ..in free-bound exchange systems (Ex-FCT), using the interaction between a ligand, a myocyte-enhancer factor 2A (MEF2A) docking peptide, and a receptor, p38?, as a model system...
  62. Yang C, Ornatsky O, McDermott J, Cruz T, Prody C. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Nucleic Acids Res. 1998;26:4771-7 pubmed
    Myocyte enhancer factor 2 (MEF2) has been implicated in the complex hierarchical regulation of muscle-specific gene expression and differentiation...
  63. Berger I, Bieniossek C, Schaffitzel C, Hassler M, Santelli E, Richmond T. Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2. J Biol Chem. 2003;278:17625-35 pubmed
    ..studies is utilized to define and characterize a stable core domain of HDAC5 and to examine its interactions with MEF2a and calmodulin...
  64. Zhao W, Zheng X, Peng D, Zhao S. Myocyte Enhancer Factor 2A Regulates Hydrogen Peroxide-Induced Senescence of Vascular Smooth Muscle Cells Via microRNA-143. J Cell Physiol. 2015;230:2202-11 pubmed publisher
    Myocyte enhancer factor 2A (MEF2A) is involved in vascular smooth muscle cell (VSMC) proliferation, migration, and senescence. MicroRNA-143/145 (miR-143/145), which may be regulated by MEF2A, is known to promote cellular senescence...
  65. Latchney S, Jiang Y, Petrik D, Eisch A, Hsieh J. Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. FASEB J. 2015;29:5059-71 pubmed publisher
    ..We used a transgenic mouse in which Mef2a, -c, and -d were inducibly deleted in adult nestin-expressing NSPCs and their progeny...
  66. Xu D, Tian H, Cai W, Zheng J, Gao M, Zhang M, et al. Novel 6-bp deletion in MEF2A linked to premature coronary artery disease in a large Chinese family. Mol Med Rep. 2016;14:649-54 pubmed publisher
    ..and Sanger sequencing, a novel 6?base pair (bp) 'CAGCCG' deletion in exon 11 of the myocyte enhancer factor 2A (MEF2A) gene was identified, which cosegregated with CAD/MI cases in this family...
  67. Okamoto S, Krainc D, Sherman K, Lipton S. Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc Natl Acad Sci U S A. 2000;97:7561-6 pubmed
    ..Although MEF2 is known as a myogenic factor, the expression pattern of the MEF2 family of genes (MEF2A-D) in developing brain also suggests a role in neurogenesis...
  68. Wales S, Hashemi S, Blais A, McDermott J. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014;42:11349-62 pubmed publisher
    ..To define the overlapping and unique MEF2A genomic targets, we utilized ChIP-exo analysis of cardiomyocytes and skeletal myoblasts...
  69. Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García Calzón S, Peijs L, et al. Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects. BMC Med. 2017;15:39 pubmed publisher
    ..epigenetic and transcriptional changes of myogenic transcription factors (MYOD1, MYOG, MYF5, MYF6, PAX7, MEF2A, MEF2C, and MEF2D), cell cycle regulators, metabolic enzymes and genes previously not linked to myogenesis, ..
  70. Black B, Molkentin J, Olson E. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Mol Cell Biol. 1998;18:69-77 pubmed
    ..transcription and myogenesis through protein-protein interactions with members of the myocyte enhancer factor 2 (MEF2) family of MADS domain transcription factors...
  71. Sellathurai J, Nielsen J, Hejbøl E, Jørgensen L, Dhawan J, Nielsen M, et al. Low Oxygen Tension Enhances Expression of Myogenic Genes When Human Myoblasts Are Activated from G0 Arrest. PLoS ONE. 2016;11:e0158860 pubmed publisher
    ..showed up regulation of the myogenesis related genes PAX3, PAX7, MYOD, MYOG (myogenin), MET, NCAM, DES (desmin), MEF2A, MEF2C and CDH15 (M-cadherin), however, the fraction of DES and MYOD positive cells was not increased by low ..
  72. Zheng R, Wang X, Studzinski G. 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2C. J Steroid Biochem Mol Biol. 2015;148:132-7 pubmed publisher
    ..Among the four isoforms (Mef2A, 2B, 2C, and 2D), Mef2C was also found to play important roles in hematopoiesis...
  73. Chen X, Lv R, Zhang W, Yan Y, Li P, Dong W, et al. Inhibition of myocyte-specific enhancer factor 2A improved diabetic cardiac fibrosis partially by regulating endothelial-to-mesenchymal transition. Oncotarget. 2016;7:31053-66 pubmed publisher
    ..This study sought to identify whether inhibition of Myocyte enhancer factor 2A (MEF2A) alleviates cardiac fibrosis by partially regulating Endothelial-to-mesenchymal transition (EndMT)...
  74. Gjyshi A, Dash S, Cen L, Cheng C, Zhang C, Yoder S, et al. Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine. Sci Rep. 2018;8:8291 pubmed publisher
    ..We identified HOXA5, SPIB, REL, SRF, SP1, NFKB1, MEF2A, E2F1, and EGR1 transcription factor binding sites to be highly enriched in our dataset...
  75. Liu X, Jin E, Zhi J, Li X. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. Mol Med Rep. 2011;4:465-9 pubmed publisher
    The MADS box-containing transcription factors MEF2A-D regulate the expression of most skeletal and cardiac muscle structural genes...
  76. Chen L, Cheng B, Li L, Zhan S, Wang L, Zhong T, et al. The molecular characterization and temporal-spatial expression of myocyte enhancer factor 2 genes in the goat and their association with myofiber traits. Gene. 2015;555:223-30 pubmed publisher
    The myocyte enhancer factor-2 (MEF2) gene family in vertebrates includes MEF2A, MEF2B, MEF2C, and MEF2D, which have important functions in the regulation of muscular growth and development...
  77. Liu Y, Niu W, Wu Z, Su X, Chen Q, Lu L, et al. Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis. PLoS ONE. 2012;7:e31406 pubmed publisher
    ..Association of CAD with variants in the myocyte enhancer factor 2A (MEF2A) gene, the first identified CAD-causing gene, has attracted special attention but the results are controversial...
  78. Yu Y, Breitbart R, Smoot L, Lee Y, Mahdavi V, Nadal Ginard B. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 1992;6:1783-98 pubmed
    The MEF2 site is an essential element of muscle enhancers and promoters that is bound by a nuclear activity found, so far, only in muscle and required for tissue-specific transcription...
  79. Borghi S, Molinari S, Razzini G, Parise F, Battini R, Ferrari S. The nuclear localization domain of the MEF2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4. J Cell Sci. 2001;114:4477-83 pubmed
    ..Co-transfection of either MEF2A or MEF2C causes HDAC4 to accumulate in the nucleus in association with MEF2...
  80. Tobin S, Hashemi S, Dadson K, Turdi S, Ebrahimian K, Zhao J, et al. Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers. Sci Rep. 2017;7:4476 pubmed publisher
    ..Transcriptome analysis (RNA-seq) from left ventricular RNA samples and MEF2A depleted cardiomyocytes was performed...
  81. Lee S, Choi Y, Cho N. Association between pathologic factors and ERG expression in prostate cancer: finding pivotal networking. J Cancer Res Clin Oncol. 2018;144:1665-1683 pubmed publisher
    ..Regulatory network analysis identified NOTCH1, MEF2C, STAT3, LCK, CACNA2D3, PCSK7, MEF2A, PDZD2, TAB1, and ASGR1 as pivotal genes...
  82. Di Giorgio E, Franforte E, Cefalù S, Rossi S, Dei Tos A, Brenca M, et al. The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness. PLoS Genet. 2017;13:e1006752 pubmed publisher
    The contribution of MEF2 TFs to the tumorigenic process is still mysterious...
  83. Liu G, Han J, Profirovic J, Strekalova E, Voyno Yasenetskaya T. Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Angiogenesis. 2009;12:1-15 pubmed publisher
    ..Here, we show that myocyte-specific enhancer factor-2 (MEF2) mediates Galpha13-dependent angiogenesis...
  84. Perry R, Yang C, Soora N, Salma J, Marback M, Naghibi L, et al. Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression. Mol Cell Biol. 2009;29:3355-66 pubmed publisher
    The myocyte enhancer factor 2 (MEF2) transcription factors play important roles in neuronal, cardiac, and skeletal muscle tissues...
  85. Yuan H, Niu Y, Liu X, Fu L. Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Acta Physiol (Oxf). 2014;212:283-92 pubmed publisher
    ..A myocyte-specific enhancer factor (MEF2) site that binds MEF2A in the promoter of Cpt1b has been identified...
  86. Jain P, Lavorgna A, Sehgal M, Gao L, Ginwala R, Sagar D, et al. Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology. 2015;12:23 pubmed publisher
    ..We demonstrate the involvement of MEF-2 in Tax-mediated LTR activation, viral replication, and T-cell transformation in correlation with its heightened expression in ATL patients through direct binding to DNA within the HTLV-1 LTR. ..
  87. Xu K, Zhao Y. MEF2D/Wnt/β-catenin pathway regulates the proliferation of gastric cancer cells and is regulated by microRNA-19. Tumour Biol. 2016;37:9059-69 pubmed publisher
    ..In present study, we first explored MEF2's expression in gastric cancer, finding that only MEF2D rather than MEF2A, 2B, or 2C was elevated in gastric cancer clinical specimens...
  88. Paradis F, Wood K, Swanson K, Miller S, McBride B, Fitzsimmons C. Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics. 2017;18:632 pubmed publisher
    ..Receptor (INSR)), myogenic (Myogenic Differentiation 1 (MYOD1), Myogenin (MYOG), Myocyte Enhancer Factor 2A (MEF2A), Serum Response Factor (SRF)) and adipogenic (Peroxisome Proliferator Activated Receptor Gamma (PPARG)) genes in ..
  89. Estrella N, Desjardins C, Nocco S, Clark A, Maksimenko Y, Naya F. MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation. J Biol Chem. 2015;290:1256-68 pubmed publisher
    ..By contrast, vertebrate MEF2 is encoded by four distinct genes, Mef2a, -b, -c, and -d, making it far more challenging to link this transcription factor to the regulation of specific ..
  90. Liu J, Wen D, Fang X, Wang X, Liu T, Zhu J. p38MAPK Signaling Enhances Glycolysis Through the Up-Regulation of the Glucose Transporter GLUT-4 in Gastric Cancer Cells. Cell Physiol Biochem. 2015;36:155-65 pubmed publisher
    ..Our data indicate that the abnormal activation of p38MAPK promotes glycolysis within gastric cancer cells through the upregulation of GLUT-4 in a MEF2a-dependent manner.
  91. Aguilar O, Hadj Moussa H, Storey K. Freeze-responsive regulation of MEF2 proteins and downstream gene networks in muscles of the wood frog, Rana sylvatica. J Therm Biol. 2017;67:1-8 pubmed publisher
    ..Immunoblotting, subcellular localization, and RT-PCR were used to analyze the regulation of MEF2A and MEF2C transcription factors and selected downstream targets under their control at transcriptional, ..