Gene Symbol: MED23
Description: mediator complex subunit 23
Alias: ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2, mediator of RNA polymerase II transcription subunit 23, 130 kDa transcriptional co-activator, 133 kDa transcriptional co-activator, activator-recruited cofactor 130 kDa component, cofactor required for Sp1 transcriptional activation subunit 3, vitamin D3 receptor interacting protein
Species: human
Products:     MED23

Top Publications

  1. Akoulitchev S, Chuikov S, Reinberg D. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature. 2000;407:102-6 pubmed
    ..Our results link the Mediator complex and the basal transcription machinery by a regulatory pathway involving two cyclin-dependent kinases. This pathway appears to be unique to higher organisms. ..
  2. Stevens J, Cantin G, Wang G, Shevchenko A, Shevchenko A, Berk A. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science. 2002;296:755-8 pubmed
    b>Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans...
  3. Mo X, Kowenz Leutz E, Xu H, Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol Cell. 2004;13:241-50 pubmed
    ..Active and repressive C/EBPbeta interacts with multisubunit Mediator complexes through the CRSP130/Sur2 subunit...
  4. Meyer K, Donner A, Knuesel M, York A, Espinosa J, Taatjes D. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 2008;27:1447-57 pubmed publisher
    ..Indeed our results suggest that T/G-Mediator directs early events-such as modification of chromatin templates-in transcriptional activation. ..
  5. Ding N, Zhou H, Esteve P, Chin H, Kim S, Xu X, et al. Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell. 2008;31:347-59 pubmed publisher
    ..These findings implicate Mediator in epigenetic restriction of neuronal gene expression to the nervous system and suggest a pathologic basis for MED12-associated XLMR involving impaired REST-dependent neuronal gene regulation. ..
  6. Shimbo T, Adachi T, Fujisawa S, Hongoh M, Ohba T, Ono K. In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat. J Pharmacol Sci. 2016;131:267-74 pubmed publisher
    ..1), KCNJ11 (Kir6.2), ABCC8 (SUR1) and ABCC9 (SUR2) subunits of the KATP channel in the rat lower esophagus...
  7. Babenko A, Gonzalez G, Bryan J. Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers. J Biol Chem. 2000;275:717-20 pubmed
    ..The SUR2 segment containing the 12th through 17th predicted transmembrane domains, TMD12-17, confers sensitivity to the ..
  8. Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner G, Johnson R, et al. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol. 2012;303:F339-49 pubmed publisher
    ..Interestingly, these two cell types express sulfonylurea receptor 2 (SUR2), a binding site of nicorandil in the ATP-dependent K channel...
  9. Kawano T, Zoga V, McCallum J, Wu H, Gemes G, Liang M, et al. ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury. Neuroscience. 2009;162:431-43 pubmed publisher
    ..Using specific antibodies, we identified SUR1, SUR2, and Kir6.2 but not Kir6.1 subunits in DRGs...

More Information

Publications110 found, 100 shown here

  1. Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet. 2007;39:1453-60 pubmed
    ..The phenotype is due to a null allele of Kcnj8, encoding Kir6.1, a protein that combines with SUR2 to form an ATP-sensitive potassium channel (K(ATP)) expressed in coronary artery smooth muscle and endothelial ..
  2. Newfield R. Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth. Med Hypotheses. 2015;85:969-71 pubmed publisher
    ..This approach can also be applied to rare cases of Cantú syndrome, caused by mutations in ABCC9 (coding for SUR2) or in KCNJ8 (coding for Kir6.1) that is characterized by congenital hypertrichosis...
  3. Simard J, Chen M. Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes. J Neurosurg Anesthesiol. 2004;16:98-9 pubmed
    ..mRNA transcription and protein expression of SUR1 but not SUR2 were confirmed in reactive astrocytes both in situ and after isolation, whereas Kir6...
  4. Lee K, Dixon A, Richardson P, Pinnock R. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol. 1999;515 ( Pt 2):439-52 pubmed
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  5. Benamer N, Vasquez C, Mahoney V, Steinhardt M, Coetzee W, Morley G. Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts. Am J Physiol Heart Circ Physiol. 2013;304:H1231-9 pubmed publisher
    ..4 ± 7.5 pA/pF at 50 mV) in sMI-Fb that was inhibited with 10 ?mol/l glibenclamide. Kir6.2 and SUR2 transcript levels were elevated in sMI-Fb. Treatment with Kir6...
  6. Noh J, Hoang V, Kim Y, Kang J, Yang D. Chryseobacterium ginsengiterrae sp. nov., with Beta-Glucosidase Activity Isolated from Soil of a Ginseng Field. Curr Microbiol. 2017;74:1417-1424 pubmed publisher
    ..nov DCY68T belonged to the family Flavobacteriaceae and was most closely related to C. limigenitum SUR2T (97.4%). The genomic DNA G+C content was 42.0 mol%. The predominant quinones were MK-6 (74...
  7. Kharade S, Nichols C, Denton J. The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics. Future Med Chem. 2016;8:789-802 pubmed publisher
    ..Small-molecule inhibitors (e.g., sulfonylurea drugs) or activators (e.g., diazoxide) acting on SUR1 or SUR2 have been used clinically for decades to manage the inappropriate secretion of insulin in patients with Type 2 ..
  8. Bondjers C, He L, Takemoto M, Norlin J, Asker N, Hellstrom M, et al. Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J. 2006;20:1703-5 pubmed
    ..1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta homologue 1 (DLK1) for in situ ..
  9. Allebrandt K, Amin N, Muller Myhsok B, Esko T, Teder Laving M, Azevedo R, et al. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry. 2013;18:122-32 pubmed publisher
    ..ABCC9 encodes an ATP-sensitive potassium channel subunit (SUR2), serving as a sensor of intracellular energy metabolism.
  10. Yang Y, Li S, Konduru A, Zhang S, Trower T, Shi W, et al. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012;303:C1045-54 pubmed publisher
    ..Luciferase reporter assays indicated that the 3'-untranslated regions (UTRs) of the Kir6.1 but not SUR2 mRNA were targeted by MGO...
  11. Tessadori F, Roessler H, Savelberg S, Chocron S, Kamel S, Duran K, et al. Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Dis Model Mech. 2018;11: pubmed publisher
    ..1, KCNJ8) and regulatory (SUR2, ABCC9) subunits of an ATP-sensitive potassium channel (KATP) linked to Cantú syndrome (CS)...
  12. Wang Y, Zheng H, Liu S. Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin. J Huazhong Univ Sci Technolog Med Sci. 2009;29:8-11 pubmed publisher
    ..The results showed that the expression of SUR2, not SUR1 was detected in adipose tissue, preadipocytes and adipocytes...
  13. Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, Seino S. Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol Genomics. 2006;24:290-7 pubmed
    ..We also identified zebrafish orthologs corresponding to mammalian SUR1 (zSUR1) and SUR2 (zSUR2) by the genomic database. Both Kir6...
  14. Tagmose T, Schou S, Mogensen J, Nielsen F, Arkhammar P, Wahl P, et al. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. J Med Chem. 2004;47:3202-11 pubmed
    ..It also highlights that small structural changes can dramatically shift the efficacy of the cyanoguanidine type of selective activators of Kir6.2/SUR2 potassium channels.
  15. Tajada S, Cidad P, Moreno Domínguez A, Pérez García M, López López J. High blood pressure associates with the remodelling of inward rectifier K+ channels in mice mesenteric vascular smooth muscle cells. J Physiol. 2012;590:6075-91 pubmed publisher
    ..We found a decrease in the expression of Kir2.1, Kir4.1, Kir6.x and SUR2 mRNA in BPH VSMCs, and a decreased functional contribution of both K(IR) and K(ATP) channels in isolated BPH VSMCs...
  16. Skraban J, Kyrpides N, Shapiro N, Whitman W, Trcek J. Draft genome sequence of Chryseobacterium limigenitum SUR2T (LMG 28734T) isolated from dehydrated sludge. Braz J Microbiol. 2018;49:5-6 pubmed publisher
    The type strain SUR2 of the novel species Chryseobacterium limigenitum was isolated from a dehydrated sludge of the municipal sewage treatment plant in Dogoše near Maribor in Slovenia. The draft genome, with 60 contigs, 4,697,725bp, 34...
  17. Rainbow R, James M, Hudman D, Al Johi M, Singh H, Watson P, et al. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J. 2004;379:173-81 pubmed
    ..ATP- and glibenclamide-sensitive K+ currents were decreased in HEK-293 cells expressing full-length Kir6 and SUR2 subunits that were transiently transfected with fragments rSUR2A-CTA, rSUR2A-CTC and rSUR2A-CTE (residues 1294-1359)..
  18. Figueiredo T, Melo U, Pessoa A, Nóbrega P, Kitajima J, Correa I, et al. Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family. J Med Genet. 2015;52:123-7 pubmed publisher
    ..Deleterious mutations in MED12, MED17 and MED23 have already been associated with ID...
  19. Flagg T, Enkvetchakul D, Koster J, Nichols C. Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev. 2010;90:799-829 pubmed publisher
    ..1 or Kir6.2 pore-forming subunits with regulatory sulfonylurea receptor subunits, SUR1 or SUR2, the differential assembly of K(ATP) channels in different tissues gives rise to tissue-specific physiological and ..
  20. Qi K, Li L, Li X, Zhao J, Wang Y, you S, et al. Cardiac microvascular barrier function mediates the protection of Tongxinluo against myocardial ischemia/reperfusion injury. PLoS ONE. 2015;10:e0119846 pubmed publisher
    ..64, R2=0.62, P<0.01, respectively). TXL recovers SUR2, iNOS activity, eNOS activity, VE-cadherin, β-catenin, γ-catenin and P-selectin with a trend toward the sham ..
  21. Tricarico D, Maqoud F, Curci A, Camerino G, Zizzo N, Denora N, et al. Characterization of minoxidil/hydroxypropyl-?-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat. Eur J Pharm Biopharm. 2018;122:146-157 pubmed publisher
    ..The MXD/HP-?-CD GEL significantly enhanced the mRNA levels of the SUR2 and Kir6.1 subunits of the KATP channels and AKT2 vs other groups...
  22. Tani M, Toume M. Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase. Microbiology. 2015;161:2369-83 pubmed publisher
    ..or an increase in the hydroxylation level of the ceramide moiety of sphingolipids on overexpression of Scs7 and Sur2 sphingolipid hydroxylases enhanced the growth defect of V-ATPase-deleted cells at pH 7.2...
  23. Levin M, Singh G, Zhang H, Uchida K, Kozel B, Stein P, et al. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016;113:6773-8 pubmed publisher
    ..1, KCNJ8) and accessory (SUR2, ABCC9) KATP channel subunits...
  24. Dolan W, Chapple C. Transcriptome Analysis of Four Arabidopsis thaliana Mediator Tail Mutants Reveals Overlapping and Unique Functions in Gene Regulation. G3 (Bethesda). 2018;8:3093-3108 pubmed publisher
    ..Here, we explore the functions of four Arabidopsis Mediator tail subunits, MED2, MED5a/b, MED16, and MED23, by comparing the impact of mutations in each on the Arabidopsis transcriptome...
  25. Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, et al. Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Res. 2016;44:6853-67 pubmed publisher
    ..Upon stimulation, Brd4 recruits P-TEFb to Spt5/DSIF via a recruitment pathway consisting of Med1, Med23 and Tat-SF1, whereas SEC recruits P-TEFb to NELF-A and NELF-E via Paf1c and Med26, respectively...
  26. Streubel G, Bracken A. MED23: a new Mediator of H2B monoubiquitylation. EMBO J. 2015;34:2863-4 pubmed publisher
    ..In this issue of The EMBO Journal, Yao et al (2015) report that the MED23 subunit of the Mediator complex physically associates with the heterodimeric RNF20/40 E3‐ligase complex to ..
  27. Bhagwat A, Roe J, Mok B, Hohmann A, Shi J, Vakoc C. BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Rep. 2016;15:519-530 pubmed publisher
    ..A shRNA screen of Mediator in AML cells identified the MED12, MED13, MED23, and MED24 subunits as performing a similar regulatory function to BRD4 in this context, including a shared role ..
  28. Leon Guerrero C, Pathak S, Grange D, Singh G, Nichols C, Lee J, et al. Neurologic and neuroimaging manifestations of Cantú syndrome: A case series. Neurology. 2016;87:270-6 pubmed publisher
    ..Involvement of the KATP SUR2/Kir6.1 subtype potentially plays an important role in the neurologic manifestations of Cantú syndrome.
  29. Nakaya H, Miki T, Seino S, Yamada K, Inagaki N, Suzuki M, et al. [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]. Nihon Yakurigaku Zasshi. 2003;122:243-50 pubmed
    ..1 or Kir6.2) and the regulatory subunit sulfonylurea receptors (SUR1 or SUR2)...
  30. Bayat G, Javan M, Safari F, Khalili A, Shokri S, Goudarzvand M, et al. Nandrolone decanoate negatively reverses the beneficial effects of exercise on cardiac muscle via sarcolemmal, but not mitochondrial K(ATP) channel. Can J Physiol Pharmacol. 2016;94:324-31 pubmed publisher
    ..The expression of sarcolemmal, but not mitochondrial, subunits of K(ATP) channel (Kir6.2 and SUR2) of EC group was significantly higher compared with SC group while ND administration (SND group) did not show any ..
  31. Asada S, Choi Y, Yamada M, Wang S, Hung M, Qin J, et al. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A. 2002;99:12747-52 pubmed
    ..of the Her2 gene can be decreased by inhibiting the interaction of the two cancer-linked proteins, DRIP130/CRSP130/Sur-2 (a Ras-linked subunit of human mediator complexes) and ESX (an epithelial-restricted transcription factor)...
  32. Thomzig A, Laube G, Prüss H, Veh R. Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain. J Comp Neurol. 2005;484:313-30 pubmed
    ..0-family (Kir6.1 or Kir6.2) and a sulfonylurea receptor (SUR1, SUR2, SUR2A, SUR2B) with regulatory activity...
  33. Liu D, Liu X, Zhou L, Feng X, Zhang X. Expression of sulfonylurea receptors in rat taste buds. Acta Histochem. 2011;113:489-92 pubmed publisher
    ..was used to detect the expression and distribution of sulfonylurea receptor 1 (SUR1) or sulfonylurea receptor 2 (SUR2) in rat taste buds...
  34. Tammaro P, Ashcroft F. The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits. J Physiol. 2007;581:1259-69 pubmed
    ..2-F333I/SUR channel types was reduced, although SUR1-containing channels were reduced more than SUR2-containing channels. These results suggest F333 is involved in differential coupling of Kir6.2 to SUR1 and SUR2...
  35. Fatima N, Cohen D, Sukumar G, Sissung T, Schooley J, Haigney M, et al. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis. Front Pharmacol. 2015;6:168 pubmed publisher
    ..Two different HDIs, romidepsin and trichostatin A, caused ~20-fold increase in SUR2 (Abcc9) subunit mRNA expression in HL-1 cardiomyocytes...
  36. Chutkow W, Makielski J, Nelson D, Burant C, Fan Z. Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel. J Biol Chem. 1999;274:13656-65 pubmed
    ..has shown that alternative usage of exons 14, 39, and 40 of the muscle-specific KATP channel regulatory subunit, sur2, occurs in tissue-specific patterns...
  37. Stoller D, Kakkar R, Smelley M, Chalupsky K, Earley J, Shi N, et al. Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress. J Mol Cell Cardiol. 2007;43:445-54 pubmed
    ..2 subunit and the regulatory sulfonylurea receptor 2 (SUR2)...
  38. Näär A, Beaurang P, Zhou S, Abraham S, Solomon W, Tjian R. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature. 1999;398:828-32 pubmed
    ..Thus, ARC/DRIP is a large composite co-activator that belongs to a family of related cofactors and is targeted by different classes of activator to mediate transcriptional stimulation. ..
  39. Akao M, Otani H, Horie M, Takano M, Kuniyasu A, Nakayama H, et al. Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts. J Clin Invest. 1997;100:3053-9 pubmed
    ..1 and/or Kir6.2) subunit and the sulfonylurea receptor (SUR2). This channel is activated during myocardial ischemia and protects the heart from ischemic injury...
  40. Yao X, Tang Z, Fu X, Yin J, Liang Y, Li C, et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015;34:2885-902 pubmed publisher
    ..Here, we analyze differential histone modifications between WT and MED23(-/-) (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone ..
  41. Yokoshiki H, Sunagawa M, Seki T, Sperelakis N. Antisense oligodeoxynucleotides of sulfonylurea receptors inhibit ATP-sensitive K+ channels in cultured neonatal rat ventricular cells. Pflugers Arch. 1999;437:400-8 pubmed
    ..8 pA/pF in control (n=48), 34.3+/-3.5 pA/pF in AS-SUR1 (n=21, P<0.05 vs control), and 23.5+/-3.4 pA/pF in AS-SUR2 (n=17, P<0.01 vs control). As a control, scramble oligonucleotides had no effect...
  42. Yang X, Zhao M, Xia M, Liu Y, Yan J, Ji H, et al. Selective requirement for Mediator MED23 in Ras-active lung cancer. Proc Natl Acad Sci U S A. 2012;109:E2813-22 pubmed publisher
    ..However, the development of Ras-targeted therapeutics remains challenging. Here, we show that MED23, a component of the multisubunit Mediator complex that is known to integrate signaling and gene activities, is ..
  43. Skov V, Burton M, Thomassen M, Stauffer Larsen T, Riley C, Brinch Madelung A, et al. A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis. PLoS ONE. 2016;11:e0161570 pubmed publisher
    ..Our 7-gene signature may be a useful tool to differentiate between genuine ET and prePMF but needs to be validated in a larger cohort of "ET" patients. ..
  44. Edwards A, Rees M, Gioscia R, Zachman D, Lynch J, Browder J, et al. PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction. J Physiol. 2009;587:5723-37 pubmed publisher
    ..HMR, 27 +/- 3%), and PKC blockade had no additional effect (HMR + Chel, 26 +/- 2%). The prevalence of Kir6.2 and SUR2 was higher in the sarcolemmal fractions of females (Kir6.2: F, 1.24 +/- 0.07 vs. M, 1.02 +/- 0.06; SUR2: F, 3...
  45. Maeda Y, Rachez C, Hawel L, Byus C, Freedman L, Sladek F. Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. Mol Endocrinol. 2002;16:1502-10 pubmed
    ..These results lead us to propose a model in which polyamines may facilitate the switch between different coactivator complexes binding to NRs. ..
  46. Yang F, Vought B, Satterlee J, Walker A, Jim Sun Z, Watts J, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006;442:700-4 pubmed
    ..Taken together, our findings demonstrate that ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans. ..
  47. Dorschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Mol Pharmacol. 1999;55:1060-6 pubmed
    ..Affinities of sulfonylureas for rat SUR2A, rat or human SUR2B, and a SUR2 chimera containing the C-terminal 42 amino acids of SUR1 did not differ significantly, implying that the C terminus ..
  48. Hambrock A, Kayar T, Stumpp D, Osswald H. Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators. Diabetes. 2004;53 Suppl 3:S128-34 pubmed
    ..SUR isoform, shows much higher affinity for glibenclamide but considerably lower affinity for most openers than SUR2. In radioligand binding assays, we investigated the role of two amino acids, T1285 and M1289, located in ..
  49. Nichols C. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Card Electrophysiol Clin. 2016;8:323-35 pubmed publisher
    ..The growing association of Kir6.1 and SUR2 variants with specific cardiovascular electrical and contractile derangements and the clear association with Cantu ..
  50. Ribeiro C, Silva C, Drost D, Novaes E, Novaes C, Dervinis C, et al. Integration of genetic, genomic and transcriptomic information identifies putative regulators of adventitious root formation in Populus. BMC Plant Biol. 2016;16:66 pubmed publisher
    ..located within the QTL intervals for number of AR, including putative homologs of the Arabidopsis genes SUPERROOT2 (SUR2) and TRYPTOPHAN SYNTHASE ALPHA CHAIN (TSA1), both of which are involved in the auxin indole-3-acetic acid (IAA) ..
  51. Mahalak K, Jama A, Billups S, Dawes A, Chamberlin H. Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development. Dev Genes Evol. 2017;227:213-218 pubmed publisher
    ..We identify that the gene affected in the mutant strain is Cbr-sur-2, which encodes a MED23 mediator complex protein that acts downstream of EGF signaling in C. elegans and other organisms, such as mammals...
  52. Qian L, Shen S, Chen J, Ji L, Cao S. Peripheral KATP activation inhibits pain sensitization induced by skin/muscle incision and retraction via the nuclear factor-?B/c-Jun N-terminal kinase signaling pathway. Mol Med Rep. 2016;14:2632-8 pubmed publisher
    ..Western blotting was performed to detect the alterations in the subunits of the KATP channels, Kir6.1 and SUR2, levels of nuclear factor??B (NF??B) in the tissue around the incision and c?Jun N?terminal kinase (JNK) in the ..
  53. Aggarwal N, Pravdic D, McNally E, Bosnjak Z, Shi N, Makielski J. The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice. Am J Physiol Heart Circ Physiol. 2010;299:H1884-90 pubmed publisher
    The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (K(ATP)) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury...
  54. Hua X, Hyland P, Huang J, Song L, Zhu B, Caporaso N, et al. MEGSA: A Powerful and Flexible Framework for Analyzing Mutual Exclusivity of Tumor Mutations. Am J Hum Genet. 2016;98:442-455 pubmed publisher
    ..7 × 10(-4)). For breast cancer, we identified a significant MEGS consisting of TP53 and four infrequently mutated genes (ARID1A, AKT1, MED23, and TBL1XR1), providing support for their role as cancer drivers.
  55. Lybaert P, Vanbellinghen A, Quertinmont E, Petein M, Meuris S, Lebrun P. KATP channel subunits are expressed in the epididymal epithelium in several mammalian species. Biol Reprod. 2008;79:253-61 pubmed publisher
    ..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells ..
  56. Uhde I, Toman A, Gross I, Schwanstecher C, Schwanstecher M. Identification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem. 1999;274:28079-82 pubmed
    ..between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding...
  57. Zhou M, He H, Tanaka O, Suzuki R, Sekiguchi M, Yasuoka Y, et al. Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium. Tohoku J Exp Med. 2008;214:247-56 pubmed
    ..The SURs are divided into two isoforms, SUR1 and SUR2, the latter was further divided into SUR2A and SUR2B...
  58. Zhou M, He H, Tanaka O, Sekiguchi M, Kawahara K, Abe H. Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain. Neurosci Res. 2012;74:91-105 pubmed publisher
    ..b>SUR2 mRNA is widely expressed in many neurons and glial cells as revealed by in situ hybridization histochemistry...
  59. Shi J, Liu H, Yao F, Zhong C, Zhao H. Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells. Tumour Biol. 2014;35:12005-13 pubmed publisher
    Mediator complex subunit MED23 has been reported to facilitate the transformation induced by oncogenic Ras in non-small-cell lung carcinoma (NSCLC)...
  60. Dolan W, Dilkes B, Stout J, Bonawitz N, Chapple C. Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis. Plant Cell. 2017;29:3269-3285 pubmed publisher
    ..Together, our data highlight the interdependence of individual Mediator subunits and provide greater insight into the transcriptional regulation of phenylpropanoid biosynthesis by the Mediator complex. ..
  61. Fan Z, Makielski J. Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition. J Gen Physiol. 1999;114:251-69 pubmed
    ..clamp technique in cardiac myocytes and in COS-1 cells in which the cardiac isoform of the sulfonylurea receptor, SUR2, was coexpressed with the inwardly rectifying channel Kir6.2...
  62. Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, et al. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J. 2003;22:6494-504 pubmed
    ..Despite many known targets of VP16, ARC92/ACID1 appears to impose a critical control on transcription activation by VP16 in mammalian cells. ..
  63. Cuong D, Kim N, Joo H, Youm J, Chung J, Lee Y, et al. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Mitochondrion. 2005;5:121-33 pubmed
    ..Anti-Kir6.1, anti-Kir6.2, and anti-SUR2 immunofluorescence was colocalized with that of MitoTracker Red in isolated mitochondria, suggesting that Kir6...
  64. Kim D, Kim I, Papreck J, Donnelly D, Carroll J. Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells. Respir Physiol Neurobiol. 2011;177:247-55 pubmed publisher
    ..Reverse transcriptase-PCR and immunocytochemistry showed that Kir6.1, Kir6.2, SUR1 and SUR2 were expressed in CB glomus cells as well as in non-glomus cells...
  65. Wu X, Liu W, Liu Y, Huang Z, Zhang Y, Song X. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain. 2011;152:2605-15 pubmed publisher
    ..The results showed that protein expression for K(ATP) channel subunits SUR1, SUR2, and Kir6.1, but not Kir6...
  66. Lovasz N, Ducza E, Gaspar R, Falkay G. Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium. Reproduction. 2011;142:175-81 pubmed publisher
    ..was designed to examine the expression and role of sulfonylurea-binding regulatory subunits 1 (SUR1 (ABCC8)) and 2 (SUR2 (ABCC9)) of the K(ATP) channels in the pregnant rat myometrium with particular regard to the contractility...
  67. Mitchell D, Stafford L, Li D, Bar Eli M, Liu M. Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130. Oncogene. 2007;26:1739-47 pubmed
    ..3-q23, provokes increased tumor metastasis. ..
  68. Bodenstine T, Vaidya K, Ismail A, Beck B, Diers A, Edmonds M, et al. Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression. FEBS Lett. 2012;586:27-31 pubmed publisher increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of K(ATP)...
  69. Guo Y, Wang J, Li H, Liu W, Chen D, Zhao K, et al. Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma. J Gastroenterol Hepatol. 2015;30:1094-103 pubmed publisher
    ..Here, we study the role of mediator subunit 23 (MED23), a component of the Mediator complex, in hepatocarcinogenesis...
  70. Davis Taber R, Choi W, Feng J, Hoogenboom L, McNally T, Kroeger P, et al. Molecular characterization of human SUR2-containing K(ATP) channels. Gene. 2000;256:261-70 pubmed
    The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR)...
  71. Horinaka S, Kobayashi N, Yabe A, Asakawa H, Yagi H, Mori Y, et al. Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Cardiovasc Drugs Ther. 2004;18:13-22 pubmed
    ..whether nicorandil suppresses ischemic-induced ventricular arrhythmias and enhances sulfonylurea receptors (SUR 2; subunit of K-ATP channel), endothelial nitric oxide (eNOS), and inducible nitric oxide (iNOS) expression in the ..
  72. Wang Y, Zheng H, Qin N, Yu S, Liu S. Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes. Sheng Li Xue Bao. 2007;59:8-12 pubmed
    ..We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) ..
  73. Horinaka S, Kobayashi N, Higashi T, Hara K, Hara S, Matsuoka H. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J Cardiovasc Pharmacol. 2001;38:200-10 pubmed
    ..e., an ATP-binding cassette protein sulfonylurea receptor (SUR2) and a pore-forming inward rectifier (Kir6.1 or 6.2)...
  74. Scott V, Davis Taber R, Silvia C, Hoogenboom L, Choi W, Kroeger P, et al. Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells. Eur J Pharmacol. 2004;483:195-205 pubmed
    The molecular properties of the sulfonylurea receptor 2 (SUR2) subunits of K(ATP) channels expressed in urinary bladder were assessed by polymerase chain reaction (PCR)...
  75. Fang L, Spindler K. E1A-CR3 interaction-dependent and -independent functions of mSur2 in viral replication of early region 1A mutants of mouse adenovirus type 1. J Virol. 2005;79:3267-76 pubmed
    ..At a multiplicity of infection (MOI) of 1, viruses containing CR3 replicated better in Sur2+/+ mouse embryonic fibroblasts (MEFs) than in Sur2-/- MEFs...
  76. Lewis B, Sims R, Lane W, Reinberg D. Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell. 2005;18:471-81 pubmed
    ..These data establish that CK2 acts as a switch, converting the transcriptional machinery from functioning on one type of downstream element to another. ..
  77. Nakayama S, Ohya S, Liu H, Watanabe T, Furuzono S, Wang J, et al. Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility. J Cell Sci. 2005;118:4163-73 pubmed
    ..expression of the type 1 isoform of sulphonylurea receptors (SUR1) in ICCs of the mouse ileum, but expression of SUR2 was predominant in smooth muscle...
  78. Kowenz Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010;29:1105-15 pubmed publisher
    ..Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation. ..
  79. Moreau C, Jacquet H, Prost A, D hahan N, Vivaudou M. The molecular basis of the specificity of action of K(ATP) channel openers. EMBO J. 2000;19:6644-51 pubmed
    ..g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform...
  80. Lionel A, Monfared N, Scherer S, Marshall C, Mercimek Mahmutoglu S. MED23-associated refractory epilepsy successfully treated with the ketogenic diet. Am J Med Genet A. 2016;170:2421-5 pubmed publisher
    We report a new patient with refractory epilepsy associated with a novel pathogenic homozygous MED23 variant. This 7.5-year-old boy from consanguineous parents had infantile onset global developmental delay and refractory epilepsy...
  81. Fan Z, Neff R. Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiation. J Physiol. 2000;529 Pt 3:707-21 pubmed
    ..were recorded from cell-attached and inside-out patches of rat ventricular myocytes and COS-1 cells coexpressing SUR2 and Kir6.2. KATP channel activity increased within < 1 min upon irradiation...
  82. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, et al. A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. J Biol Chem. 1996;271:24321-4 pubmed
    ..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
  83. Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br J Pharmacol. 1998;124:985-91 pubmed
  84. Adebiyi A, McNally E, Jaggar J. Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol. 2011;301:H1360-8 pubmed publisher
    ..In the present study, we used a genetic model to investigate the physiological functions of SUR2-containing K(ATP) channels in mediating vasodilation to hypoxia, oxygen and glucose deprivation (OGD) or metabolic ..
  85. Chutkow W, Samuel V, Hansen P, Pu J, Valdivia C, Makielski J, et al. Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci U S A. 2001;98:11760-4 pubmed
    ..used a gene-targeting strategy to generate mice with a disruption in the muscle-specific K(ATP) regulatory subunit, SUR2. Insertional mutagenesis of the Sur2 locus generated homozygous null (Sur2(-/-)) mice and heterozygote (Sur2(+/-)) ..
  86. Asada S, Choi Y, Uesugi M. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc. 2003;125:4992-3 pubmed
    ..between the two cancer-linked nuclear proteins, ESX (an epithelial-specific transcription factor) and Sur-2/DRIP130 (a Ras-linked subunit of the human mediator complex), which is important for the overexpression of Her2 gene in ..
  87. Hassa P, Haenni S, Buerki C, Meier N, Lane W, Owen H, et al. Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem. 2005;280:40450-64 pubmed
    ..Thus, acetylation of PARP-1 by p300/CREB-binding protein plays an important regulatory role in NF-kappaB-dependent gene activation by enhancing its functional interaction with p300 and the Mediator complex. ..
  88. Melaine N, Satie A, Lassurguere J, Desmots S, Jégou B, Samson M. Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis. Int J Androl. 2006;29:392-9 pubmed
    ..partial cDNA found, five corresponded to ABC transporters already known -Mdr1b, Mrp1, Tapl/Abcb9, Umat/Abcb6 and Sur2/Abcc9- and one presented a strong homology with mouse and human ABCB8...
  89. Deeley R, Westlake C, Cole S. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev. 2006;86:849-99 pubmed
    ..together with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) comprise the 13 members of the human "C" branch of the ATP binding cassette (ABC) superfamily...
  90. Stoller D, Fahrenbach J, Chalupsky K, Tan B, Aggarwal N, Metcalfe J, et al. Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation. Am J Physiol Heart Circ Physiol. 2010;299:H1100-8 pubmed publisher
    ..Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) channels in ..
  91. Ko L, Cardona G, Chin W. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A. 2000;97:6212-7 pubmed
    ..The C terminus of TRBP binds to CBP/p300 and DRIP130, a component of the DRIP/TRAP/ARC complex, which suggests that TRBP may activate transcription by means of such ..
  92. Goldberg S, Miele M, Hatta N, Takata M, Paquette Straub C, Freedman L, et al. Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Res. 2003;63:432-40 pubmed
    ..PCR karyotyping that refined the region on chromosome 6 identified CRSP3/DRIP130, a transcriptional coactivator, as a metastasis suppressor...