MCT1

Summary

Gene Symbol: MCT1
Description: solute carrier family 16 member 1
Alias: HHF7, MCT, MCT1, MCT1D, monocarboxylate transporter 1, MCT 1, solute carrier family 16 (monocarboxylate transporter), member 1, solute carrier family 16 (monocarboxylic acid transporters), member 1, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Species: human
Products:     MCT1

Top Publications

  1. Sonveaux P, Vegran F, Schroeder T, Wergin M, Verrax J, Rabbani Z, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008;118:3930-42 pubmed publisher
    ..We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that ..
  2. Bonen A. The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. Eur J Appl Physiol. 2001;86:6-11 pubmed
    ..In the past few years a family of MCTs (MCT1-MCT7) has been cloned...
  3. Cuff M, Lambert D, Shirazi Beechey S. Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol. 2002;539:361-71 pubmed
    ..Transport of butyrate across the colonocyte luminal membrane is mediated by the monocarboxylate transporter 1 (MCT1)...
  4. Pinheiro C, Longatto Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, et al. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch. 2008;452:139-46 pubmed publisher
    ..in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis...
  5. Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, et al. Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma. Histopathology. 2010;56:860-7 pubmed publisher
    ..Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in breast cancer progression as well as MCT regulation by CD147...
  6. Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang K, et al. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci. 2011;102:1007-13 pubmed publisher
    ..We found that the expression of the monocarboxylate transporters MCT1 and MCT4, but not MCT5, in human lung cancer cell lines was significantly correlated with invasiveness...
  7. De Oliveira A, Pinheiro C, Longatto Filho A, Brito M, Martinho O, Matos D, et al. Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). J Bioenerg Biomembr. 2012;44:171-8 pubmed publisher
    ..We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations...
  8. Sonveaux P, Copetti T, De Saedeleer C, Vegran F, Verrax J, Kennedy K, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS ONE. 2012;7:e33418 pubmed publisher
    ..In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells...
  9. Ritzhaupt A, Wood I, Ellis A, Hosie K, Shirazi Beechey S. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J Physiol. 1998;513 ( Pt 3):719-32 pubmed
    1. Oligonucleotide primers based on the human heart monocarboxylate transporter (MCT1) cDNA sequence were used to isolate a 544 bp cDNA product from human colonic RNA by reverse transcription-polymerase chain reaction (RT-PCR)...

More Information

Publications109 found, 100 shown here

  1. Halestrap A, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004;447:619-28 pubmed
    The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1-MCT4) have been demonstrated experimentally to catalyse the proton-linked transport of metabolically important monocarboxylates ..
  2. Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, et al. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology. 2003;64:380-8 pubmed
    ..Another DNA fragment was isolated from a CGI in the 5' upstream region of monocarboxylate transporter 1 (MCT1), and was methylated in 4 of 20 breast cancers...
  3. Wilson M, Meredith D, Fox J, Manoharan C, Davies A, Halestrap A. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005;280:27213-21 pubmed
    Translocation of monocarboxylate transporters MCT1 and MCT4 to the plasma membrane requires CD147 (basigin) with which they remain tightly associated. However, the importance of CD147 for MCT activity is unclear...
  4. Saksena S, Theegala S, Bansal N, Gill R, Tyagi S, Alrefai W, et al. Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2009;297:G878-85 pubmed
    ..Earlier studies from our group and others have shown that monocarboxylate transporter (MCT1) plays an important role in the transport of butyrate in the human intestine...
  5. Le Floch R, Chiche J, Marchiq I, Naïken T, Ilc K, Ilk K, et al. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A. 2011;108:16663-8 pubmed publisher
    ..Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality...
  6. Boidot R, Vegran F, Meulle A, Le Breton A, Dessy C, Sonveaux P, et al. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Cancer Res. 2012;72:939-48 pubmed publisher
    The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells...
  7. Zhao Z, Wu M, Zou C, Tang Q, Lu J, Liu D, et al. Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-?B pathway. Cancer Lett. 2014;342:150-8 pubmed publisher
    Monocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors...
  8. Kirk P, Wilson M, Heddle C, Brown M, Barclay A, Halestrap A. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000;19:3896-904 pubmed
    ..Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental ..
  9. Pinheiro C, Reis R, Ricardo S, Longatto Filho A, Schmitt F, Baltazar F. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol. 2010;2010:427694 pubmed publisher
    ..In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44...
  10. Bickham D, Bentley D, Le Rossignol P, Cameron Smith D. The effects of short-term sprint training on MCT expression in moderately endurance-trained runners. Eur J Appl Physiol. 2006;96:636-43 pubmed
    ..to assess the effects of short-term sprint training on transient changes in monocarboxylate lactate transporter 1 (MCT1) and MCT4 protein and mRNA content. Seven moderately endurance-trained runners (mean +/- SE; age 27.7+/-2...
  11. Polański R, Hodgkinson C, Fusi A, Nonaka D, Priest L, Kelly P, et al. Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin Cancer Res. 2014;20:926-937 pubmed publisher
    The monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase I evaluation in the United Kingdom. AZD3965 is proposed, via lactate transport modulation, to kill tumor cells reliant on glycolysis...
  12. Lambert D, Wood I, Ellis A, Shirazi Beechey S. Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer. 2002;86:1262-9 pubmed
    ..butyrate is transported across the luminal membrane of the colonic epithelium via a monocarboxylate transporter, MCT1. In this paper, using immunohistochemistry and in situ hybridisation histochemistry, we have determined the profile ..
  13. Gill R, Saksena S, Alrefai W, Sarwar Z, Goldstein J, Carroll R, et al. Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol. 2005;289:C846-52 pubmed
    ..Although apical SCFA uptake is mediated by the MCT1 isoform, the molecular identity of the basolateral membrane SCFA transporter(s) and whether this transporter is ..
  14. Curry J, Tuluc M, Whitaker Menezes D, Ames J, Anantharaman A, Butera A, et al. Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer. Cell Cycle. 2013;12:1371-84 pubmed publisher
    ..correlated with oxidative mitochondrial metabolism (OXPHOS) and the uptake of mitochondrial fuels, as detected via MCT1 expression (p < 0.001)...
  15. Vallée A, Lecarpentier Y, Guillevin R, Vallee J. Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway-PPAR Gamma, Energy Metabolism and Circadian Rhythms. Neuromolecular Med. 2018;20:174-204 pubmed publisher
    ..Glut), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase kinase 1(PDK1), monocarboxylate lactate transporter 1 (MCT-1), lactic dehydrogenase kinase-A (LDH-A) and inactivation of pyruvate dehydrogenase complex (PDH)...
  16. Brown L, Kohn J, Rozance P, Hay W, Wesolowski S. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017;312:R654-R663 pubmed publisher
    ..AA infusion also increased liver mRNA expression of the lactate transporter gene (MCT1), protein expression of GLUT2 and LDHA, and phosphorylation of AMPK, 4EBP1, and S6 proteins...
  17. Kant S, Kumar A, Singh S. Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms. Mol Cell Biochem. 2014;397:167-78 pubmed publisher
    ..The expression of lactate transporter MCT-1 and multidrug resistance regulating protein MRP-1 got inhibited along with hampered uptake of glucose and lactate ..
  18. Vallée A, Lecarpentier Y, Guillevin R, Vallée J. Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. J Mol Neurosci. 2017;62:368-379 pubmed publisher
    ..pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDH-A), and monocarboxylate lactate transporter (MCT-1). This phenomenon is called aerobic glycolysis or the Warburg effect...
  19. Lu Y, Zhao H, Wang Y, Han B, Wang T, Zhao H, et al. Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats. Life Sci. 2015;134:68-72 pubmed publisher
    ..staining, Western blot and qRT-PCR analyses for the expressions of lactate transporter (monocarboxylate transporter 1, MCT1) and glial fibrillary acidic protein (GFAP)...
  20. Hwang E, Sim S, Park S, Song K, Lee H, Heo T, et al. Anti-proliferative effect of Zea mays L. cob extract on rat C6 glioma cells through regulation of glycolysis, mitochondrial ROS, and apoptosis. Biomed Pharmacother. 2018;98:726-732 pubmed publisher
    ..to reduced reactive oxygen species (ROS), antiapoptotic Bcl-2 protein, and a lactate transporter monocarboxylate transporter 1 of which levels are higher than those in normal cells...
  21. Todenhöfer T, Seiler R, Stewart C, Moskalev I, Gao J, Ladhar S, et al. Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer. Mol Cancer Ther. 2018;17:2746-2755 pubmed publisher
    ..The aim of this study was to investigate the functional importance of the monocarboxylate transporter (MCT) 4 in preclinical models of urothelial carcinoma and to assess its relevance in patient tumors...
  22. Vallée A, Vallee J. Warburg effect hypothesis in autism Spectrum disorders. Mol Brain. 2018;11:1 pubmed publisher
    ..Glut), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase kinase 1(PDK1), monocarboxylate lactate transporter 1 (MCT-1), lactate dehydrogenase kinase-A (LDH-A) and inactivation of pyruvate dehydrogenase complex (PDH)...
  23. Hoshino D, Hanawa T, Takahashi Y, Masuda H, Kato M, Hatta H. Chronic post-exercise lactate administration with endurance training increases glycogen concentration and monocarboxylate transporter 1 protein in mouse white muscle. J Nutr Sci Vitaminol (Tokyo). 2014;60:413-9 pubmed publisher
    ..with training can increase muscle glycogen storage and whether such changes are associated with monocarboxylate transporter 1 (MCT1) protein expression in mice...
  24. Berrios C, Padi M, Keibler M, Park D, Molla V, Cheng J, et al. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016;12:e1006020 pubmed publisher
    ..transcriptome with increased levels of glycolytic genes, including the monocarboxylate lactate transporter SLC16A1 (MCT1)...
  25. Bonen A, Tonouchi M, Miskovic D, Heddle C, Heikkila J, Halestrap A. Isoform-specific regulation of the lactate transporters MCT1 and MCT4 by contractile activity. Am J Physiol Endocrinol Metab. 2000;279:E1131-8 pubmed
    ..After 1 and 3 wk of chronic muscle stimulation (24 h/day), MCT1 protein expression was increased in the red muscles (+78%, P < 0.05)...
  26. Joyce P, Prestidge C. Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base. Eur J Pharm Sci. 2018;118:40-48 pubmed publisher
    ..system composed of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and submicron medium-chain triglyceride (MCT) droplets was fabricated to overcome the pH-dependent solubility and precipitation challenges associated with a ..
  27. Brooks G, Brown M, Butz C, Sicurello J, Dubouchaud H. Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1. J Appl Physiol (1985). 1999;87:1713-8 pubmed
    To evaluate the potential role of monocarboxylate transporter-1 (MCT1) in tissue lactate oxidation, isolated rat subsarcolemmal and interfibrillar cardiac and skeletal muscle mitochondria were probed with an antibody to MCT1...
  28. Majumdar S, Gunda S, Pal D, Mitra A. Functional activity of a monocarboxylate transporter, MCT1, in the human retinal pigmented epithelium cell line, ARPE-19. Mol Pharm. 2005;2:109-17 pubmed
    ..of this study was to identify and characterize the functional activity of monocarboxylic acid transporter 1 (MCT1) on the human retinal pigmented epithelium (RPE) cell line, ARPE-19, and to evaluate whether the cell line can ..
  29. Pérez de Heredia F, Wood I, Trayhurn P. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. Pflugers Arch. 2010;459:509-18 pubmed publisher
    ..Screening by reverse transcription polymerase chain reaction indicated that the genes encoding MCT1, MCT2, and MCT4 are expressed in human adipose tissue, and in adipocytes and preadipocytes in culture...
  30. De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, Schuit F, et al. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis. 2012;18:1127-36 pubmed publisher
    ..The deficiency in the colonic butyrate metabolism in UC is initiated at the gene expression level and is the result of a decreased expression of SLC16A1 and enzymes in the ?-oxidation pathway of butyrate. ..
  31. Jiao H, Mu Y, Gui L, Yan F, Lin D, Sham J, et al. Increase in caveolae and caveolin-1 expression modulates agonist-induced contraction and store- and receptor-operated Ca(2+) entry in pulmonary arteries of pulmonary hypertensive rats. Vascul Pharmacol. 2016;84:55-66 pubmed publisher
    ..OAG)-induced contraction in PAs and Ca(2+) influx in PASMCs of chronic hypoxia (CH)- and monocrotaline (MCT)-induced PH rats...
  32. Chen F, Wang H, Yan J, Lai J, Cai S, Yuan L, et al. Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70. Biomed Pharmacother. 2018;101:123-128 pubmed publisher
    ..In this study, we made observations and contrasts in monocrotaline(MCT) -induced PAH rats, and found decrease in mPAP, PVR and RVHI after GSP administration...
  33. Daberkow R, White B, Cederberg R, Griffin J, Zempleni J. Monocarboxylate transporter 1 mediates biotin uptake in human peripheral blood mononuclear cells. J Nutr. 2003;133:2703-6 pubmed
    ..Transfection of Jurkat cells with an expression vector encoding MCT1 caused a 50% increase in biotin uptake; in contrast, overexpression of MCT1 did not affect biotin uptake in various ..
  34. Heidtmann H, Ruminot I, Becker H, Deitmer J. Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859. Eur J Pharmacol. 2015;762:344-9 pubmed publisher
    ..The activity of monocarboxylate transporter (MCT) isoforms 1, 2, and 4 (SLC16A1, SLC16A7, SLC16A3), which transport lactate, pyruvate and ketone bodies, were also ..
  35. Khammanivong A, Sorenson B, Ross K, Dickerson E, Hasina R, Lingen M, et al. Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. Oncotarget. 2016;7:14029-47 pubmed publisher
    ..Our findings strongly suggest that downregulation of S100A8/A9 through epigenetic mechanisms may contribute to increased proliferation, malignant transformation, and disease progression in HNSCC. ..
  36. Liu J, Han Z, Han Z, He Z. Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension. Exp Ther Med. 2016;11:467-475 pubmed
    ..By the administration of MSC-CM to monocrotaline (MCT)-induced PH rats, and the development of an in vitro co-culture system comprised of PASMCs and activated T ..
  37. Umar S, Partow Navid R, Ruffenach G, Iorga A, Moazeni S, Eghbali M. Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy. Biol Sex Differ. 2017;8:9 pubmed publisher
    ..and ApoE-deficient female mice (Young and MA) were injected with a single intraperitoneal dose of monocrotaline (MCT, 60 mg/kg). Some ApoE-deficient MA female mice that received MCT were also treated with subcutaneous E2 pellets (0...
  38. Lu M, Cao Y, Ho C, Huang Q. The enhanced anti-obesity effect and reduced gastric mucosa irritation of capsaicin-loaded nanoemulsions. Food Funct. 2017;8:1803-1809 pubmed publisher
    ..The food grade C-NE was prepared using capsaicin, medium chain triacylglycerols (MCT) (Neobee 1053), sucrose stearate S-370, Tween 80 and distilled water with an emulsion droplet size of 168 nm and a ..
  39. Wang L, Luo H, Qin G, Cao Y, Gao X, Zhang Z, et al. The Impact of Sevoflurane on Coupling of the Left Ventricular-to-Systemic Vasculature in Rats With Chronic Pulmonary Hypertension. J Cardiothorac Vasc Anesth. 2017;31:2027-2034 pubmed publisher
    ..A randomized, controlled study. University hospital. Sprague-Dawley rats. Monocrotaline (MCT) was injected intraperitoneally to induce a PH model...
  40. Vellonen K, Hakli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A. Monocarboxylate transport in human corneal epithelium and cell lines. Eur J Pharm Sci. 2010;39:241-7 pubmed publisher
    ..The aim of the present study was to assess the expression and transporter role of human MCT1, MCT3 and MCT4 in the corneal epithelium, corneal epithelial cell lines (primary HCEpiC and immortalized HCE cells) ..
  41. Shen Y, Zhao R, Wang J, Chen X, Ge X, Chen M. Waste-to-energy: Dehalogenation of plastic-containing wastes. Waste Manag. 2016;49:287-303 pubmed publisher
    ..The pre-treatment method of MCT or HTT can eliminate the halogen in plastic wastes. The additives such as alkali-based metal oxides (e.g...
  42. Kirat D, Shousha S. Angiotensin II up-regulates monocarboxylate transporters expression in the rat adrenal gland. Cell Mol Biol (Noisy-le-grand). 2016;62:24-9 pubmed
    ..The current study aims to investigate the effect of in vivo infusion of Ang II on monocarboxylate transporters (MCT1, MCT2, and MCT4) gene expression in the rat adrenal gland...
  43. Bai L, McClements D. Formation and stabilization of nanoemulsions using biosurfactants: Rhamnolipids. J Colloid Interface Sci. 2016;479:71-79 pubmed publisher
    ..In this study, the interfacial characteristics of this natural surfactant at medium chain triglyceride (MCT) oil-water interfaces were characterized, and its ability to form nanoemulsions was compared to that of another ..
  44. Alaa M, Abdellatif M, Tavares Silva M, Oliveira Pinto J, Lopes L, Leite S, et al. Right ventricular end-diastolic stiffness heralds right ventricular failure in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2016;311:H1004-H1013 pubmed publisher
    ..Our aim was to evaluate RV stiffness in monocrotaline (MCT)-induced PH progression and to validate STF gain between EDP and SV as marker of stiffness...
  45. Gao C, Wang F, Wang Z, Zhang J, Yang X. Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade. Int J Mol Med. 2016;38:1823-1830 pubmed publisher
    ..The expression levels of mitochondrial monocarboxylate transporter 1 (MCT1) and cytoplasmic cytochrome c, cleaved caspase-9 and caspase-3 were assayed by western blot analysis...
  46. Chamma C, Bargut T, Mandarim de Lacerda C, Aguila M. A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation. Food Funct. 2017;8:778-787 pubmed publisher
    We investigated the increasing amounts of medium-chain triacylglycerol (MCT) in the diet on hepatic lipid metabolism. Mature C57BL/6 male mice were randomly divided into five groups (n = 10/group)...
  47. Da Silva L, Fonseca Alves C, Thompson J, Foster R, Wood G, Amorim R, et al. Pilot assessment of vascular endothelial growth factor receptors and trafficking pathways in recurrent and metastatic canine subcutaneous mast cell tumours. Vet Med Sci. 2017;3:146-155 pubmed publisher
    Canine subcutaneous mast cell tumour (scMCT) shows less aggressive biological behaviour than cutaneous MCT. Vascular endothelial growth factor receptor 2 (VEGFR2) is expressed by neoplastic cells in canine scMCT, but the relevance of ..
  48. Fei F, Guo X, Chen Y, Liu X, Tu J, Xing J, et al. Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer. J Cancer Res Clin Oncol. 2015;141:1095-102 pubmed publisher
    ..Nine functional SNPs in three MCT genes (MCT1, MCT2 and MCT4) were selected and genotyped using Sequenom iPLEX genotyping system in 697 Chinese CRC patients ..
  49. Eichner C, Berna F. Acceptance and Efficacy of Metacognitive Training (MCT) on Positive Symptoms and Delusions in Patients With Schizophrenia: A Meta-analysis Taking Into Account Important Moderators. Schizophr Bull. 2016;42:952-62 pubmed publisher
    Metacognitive training (MCT) is a new, widely used intervention for psychosis. The present meta-analysis examines the efficacy of MCT in schizophrenia...
  50. Borbély E, Sandor K, Markovics A, Kemeny A, Pinter E, Szolcsanyi J, et al. Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees. Inflamm Res. 2016;65:725-36 pubmed publisher
    Mast cell tryptase (MCT) is elevated in arthritic joints, but its direct effects are not known. Here, we investigated MCT-evoked acute inflammatory and nociceptive mechanisms with behavioural, in vivo imaging and immunological techniques...
  51. Wilson D, Schacht S, Al Nakkash L, Babu J, Broderick T. Resveratrol prevents pulmonary trunk remodeling but not right ventricular hypertrophy in monocrotaline-induced pulmonary hypertension. Pathophysiology. 2016;23:243-250 pubmed publisher
    ..in rats with PAH was induced in male Sprague-Dawley rats by a single subcutaneous injection of monocrotaline (MCT, 60mg/kg). Rats were treated with resveratrol (25mg/kg/day) by oral gavage daily for 21days...
  52. Rathinasabapathy A, Bruce E, Espejo A, Horowitz A, Sudhan D, Nair A, et al. Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis. Br J Pharmacol. 2016;173:2859-79 pubmed publisher
    ..Monocrotaline (MCT) or bleomycin (Bleo) was injected into male Sprague-Dawley rats to induce PH or PF respectively...
  53. Deng S, Kang S, Feng N, Zhu J, Yu B, Xie X, et al. Mechanochemical mechanism of rapid dechlorination of hexachlorobenzene. J Hazard Mater. 2017;333:116-127 pubmed publisher
    Recent researches indicate that mechanochemical treatment (MCT) is a promising method to degrade the environmental hazards, especially in the area of persistent organic pollutants (POPs) disposal...
  54. Zhang L, Zhang H, Li Y, Wang T. Effects of medium-chain triglycerides on intestinal morphology and energy metabolism of intrauterine growth retarded weanling piglets. Arch Anim Nutr. 2017;71:231-245 pubmed publisher
    ..Therefore, the present study was conducted to investigate the effect of medium-chain triglycerides (MCT) on the intestinal morphology, intestinal function and energy metabolism of piglets with IUGR...
  55. Taarji N, Rabelo da Silva C, Khalid N, Gadhi C, Hafidi A, Kobayashi I, et al. Formulation and stabilization of oil-in-water nanoemulsions using a saponins-rich extract from argan oil press-cake. Food Chem. 2018;246:457-463 pubmed publisher
    ..Fifty percent (v/v) ethanolic extract reduced the interfacial tension to a minimum value at both MCT oil and soybean oil interfaces (12.7 and 10.5?mN?m-1 respectively)...
  56. Lauritzen F, de Lanerolle N, Lee T, Spencer D, Kim J, Bergersen L, et al. Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol Dis. 2011;41:577-84 pubmed publisher
    b>Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood-brain barrier...
  57. Martinez Sanchez A, Nguyen Tu M, Rutter G. DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs. Mol Endocrinol. 2015;29:1067-79 pubmed
  58. Andersen S, Solstad Ã, Moi L, Donnem T, Eilertsen M, Nordby Y, et al. Organized metabolic crime in prostate cancer: The coexpression of MCT1 in tumor and MCT4 in stroma is an independent prognosticator for biochemical failure. Urol Oncol. 2015;33:338.e9-17 pubmed publisher
    ..We aimed to explore expression of MCT1 and MCT4 in PC cells and surrounding stroma in a large cohort...
  59. Kim N, Nakamura H, Masaki H, Kumasawa K, Hirano K, Kimura T. Effect of lipid metabolism on male fertility. Biochem Biophys Res Commun. 2017;485:686-692 pubmed publisher
    ..in hyperphagia, does it affect spermatogenesis and sperm motility? In this study, we investigated the effect of a MCT replacement diet on sperm parameters using db/db mice...
  60. Soler V, Laurent C, Sakr F, Regnier A, Tricoire C, Cases O, et al. Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs. Graefes Arch Clin Exp Ophthalmol. 2017;255:1593-1604 pubmed publisher
    ..In 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined...
  61. Fisher P, Byrne A, Salmon P. Metacognitive Therapy for Emotional Distress in Adult Cancer Survivors: A Case Series. Cognit Ther Res. 2017;41:891-901 pubmed publisher
    ..this study was to test the potential of a brief transdiagnostic psychological intervention-metacognitive therapy (MCT)-in reducing emotional distress in adult cancer survivors...
  62. García Basterra I, González Gómez A, García Ben A, Morillo Sánchez M, Soler García A, Ríus Diaz F, et al. Macular choroidal thickness in non-arteritic ischemic optic neuropathy. Arch Soc Esp Oftalmol. 2016;91:223-7 pubmed publisher
    To analyse macular choroidal thickness (MCT) in non-arteritic ischaemic optic neuropathy (NAION)...
  63. Bao Z, Liao T, Yang W, Wang Y, Luo H, Wang X. Heat stress-induced autophagy promotes lactate secretion in cultured immature boar Sertoli cells by inhibiting apoptosis and driving SLC2A3, LDHA, and SLC16A1 expression. Theriogenology. 2017;87:339-348 pubmed publisher
    ..Furthermore, lactate secretion, and mRNA transcript levels of SLC2A3 (GLUT3), LDHA (LDHA), and SLC16A1 (MCT1) also showed time-dependent changes with a peak at 24 hours...
  64. Wu F, Yao W, Yang J, Zhang M, Xu Y, Hao Y, et al. Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats. Biomed Pharmacother. 2017;95:1161-1168 pubmed publisher
    ..Furthermore, aloperine also alleviated the MCT-induced changes of p27kip1, Bax and Bcl-2...
  65. Chiry O, Pellerin L, Monnet Tschudi F, Fishbein W, Merezhinskaya N, Magistretti P, et al. Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex. Brain Res. 2006;1070:65-70 pubmed
    Distribution of the monocarboxylate transporter MCT1 has been investigated in the cortex of normal adult human brain...
  66. Jin C, Gao L, Li Y, Wu S, Lu X, Yang J, et al. Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus. Exp Brain Res. 2017;235:3817-3832 pubmed publisher
    ..levels of glycogen synthetase, glycogen phosphorylase, lactate dehydrogenase A, monocarboxylate transporter 4, MCT-1, and MCT-2, and decreased total LDH activity and lactate contents in rat hippocampus...
  67. Yesilyurt H, Seckin B, Aktulay A, Ozyer S. Age-stratified analysis of tumor markers and tumor characteristics in adolescents and young women with mature cystic teratoma. J Chin Med Assoc. 2018;81:499-504 pubmed publisher
    ..Elevations of cancer antigen (CA) 125 and CA 19-9 have been reported in patients with mature cystic teratoma (MCT)...
  68. Merezhinskaya N, Ogunwuyi S, Mullick F, Fishbein W. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. J Histochem Cytochem. 2004;52:1483-93 pubmed
    ..for transcriptional and translational expression of three physiologically-proven lactate transporters, monocarboxylate transporter 1(MCT1), MCT2, and MCT4, using RT-PCR and affinity-purified rabbit antibody (Ab) to the C-terminal ..
  69. Pulz L, Barra C, Kleeb S, Xavier J, Catão Dias J, Sobral R, et al. Increased expression of tissue inhibitor of metalloproteinase-1 correlates with improved outcome in canine cutaneous mast cell tumours. Vet Comp Oncol. 2017;15:606-614 pubmed publisher
    Canine mast cell tumour (MCT) is a biologically heterogeneous disease...
  70. Zhu X, Zhang H, Zhao T, Li J, Yin H. Divergent drivers of the spatial and temporal variations of cropland carbon transfer in Liaoning province, China. Sci Rep. 2017;7:13095 pubmed publisher
    ..affected by the ratio of planting area to regional area (RPR) via its effect on the magnitude of carbon transfer (MCT), which depended mainly on fertilizer usage per area (FUA)...
  71. Nandi S, Gov N. Nonequilibrium mode-coupling theory for dense active systems of self-propelled particles. Soft Matter. 2017;13:7609-7616 pubmed publisher
    ..We develop a nonequilibrium mode-coupling theory (MCT) for such systems, where activity is included as a colored noise with the particles having a self-propulsion force ..
  72. Matsukuma S, Takahashi O, Utsumi Y, Miyai K, Takeo H. Gastrointestinal tract-like muscular walls in ovarian mature cystic teratomas: A histopathological study. Mol Clin Oncol. 2017;7:642-648 pubmed publisher
    ..features of gastrointestinal (GI) tract-like muscular walls developing in ovarian mature cystic teratoma (MCT), the present study examined 149 MCTs surgically removed from 126 females, including 23 bilateral cases...
  73. B renz F, Inoue D, Yokoyama H, Tegha Dunghu J, Freiss S, Draeger S, et al. The centriolar satellite protein SSX2IP promotes centrosome maturation. J Cell Biol. 2013;202:81-95 pubmed publisher
    ..It preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells...
  74. Stewart P, Parapatics K, Welsh E, Müller A, Cao H, Fang B, et al. A Pilot Proteogenomic Study with Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung Adenocarcinoma. PLoS ONE. 2015;10:e0142162 pubmed publisher
    ..We selected two proteins consistently overexpressed in squamous cell carcinoma in all studies, MCT1 (SLC16A1) and GLUT1 (SLC2A1), for further investigation...
  75. Wu L, Liu M, Shan W, Zhu X, Li L, Zhang Z, et al. Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs. J Control Release. 2017;262:273-283 pubmed publisher
    ..cellular uptake was achieved via specific interaction between butyrate and the monocarboxylate transporter (MCT) on cell membranes, which subsequently ameliorated transepithelial transport and intestinal absorption in the ileum...
  76. Zahabi M, Kaber D. Identification of task demands and usability issues in police use of mobile computing terminals. Appl Ergon. 2018;66:161-171 pubmed publisher
    ..This study identified the perceived importance and frequency of police mobile computing terminal (MCT) tasks, quantified the demands of different tasks using a cognitive performance modeling methodology, identified ..
  77. Otonkoski T, Jiao H, Kaminen Ahola N, Tapia Paez I, Ullah M, Parton L, et al. Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet. 2007;81:467-74 pubmed
    ..Mutational analysis of the promoter of the SLC16A1 gene, which encodes monocarboxylate transporter 1 (MCT1), located under the linkage peak, revealed changes in all 13 identified patients with EIHI...
  78. Marquard J, Welters A, Buschmann T, Barthlen W, Vogelgesang S, Klee D, et al. Association of exercise-induced hyperinsulinaemic hypoglycaemia with MCT1-expressing insulinoma. Diabetologia. 2013;56:31-5 pubmed publisher
    ..Activating promoter mutations in the MCT1 gene (also known as SCLA16A1), coding for monocarboxylate transporter 1 (MCT1), were shown to associate with EIHI...
  79. Kuma A, Tamura M, Ishimatsu N, Harada Y, Izumi H, Miyamoto T, et al. Monocarboxylate Transporter-1 Mediates the Protective Effects of Neutral-pH Bicarbonate/Lactate-Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis. Ther Apher Dial. 2017;21:62-70 pubmed publisher
    ..b>MCT-1 transports lactate into cells...
  80. Miyata T, Tajima H, Hirata M, Nakanuma S, Makino I, Hayashi H, et al. Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space. J Gastroenterol Hepatol. 2018;33:950-957 pubmed publisher
    ..This study investigated the effects of cilostazol (CZ), a phosphodiesterase III inhibitor, in a monocrotaline (MCT)-induced rat model of SOS. Male Wistar rats were administrated MCT to induce SOS...
  81. Blaha M, Martinkova J, Lanska M, Filip S, Malakova J, Kubeček O, et al. Plasma filtration for the controlled removal of liposomal therapeutics - From the apheretic site of view. Atheroscler Suppl. 2017;30:286-293 pubmed publisher
    ..tissue (kinetic targeting), while its distribution in normal tissue, which is a cause of mucocutaneous toxicity (MCT), is delayed...
  82. Pham A, Gavin P, Libinaki R, Ramirez G, Boyd B. A new lipid excipient, phosphorylated tocopherol mixture, TPM enhances the solubilisation and oral bioavailability of poorly water soluble CoQ10 in a lipid formulation. J Control Release. 2017;268:400-406 pubmed publisher
    ..In this study a commercial mixture of phosphorylated tocopherols, TPM was combined with medium chain triglyceride (MCT) as a formulation for CoQ10, and in vitro and in vivo performance compared to the effect of addition of ..
  83. Miastkowska M, Sikora E, Lasoń E, García Celma M, Escribano Ferrer E, Solans C, et al. Nano-emulsions as vehicles for topical delivery of forskolin. Acta Biochim Pol. 2017;: pubmed publisher
    Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems...
  84. Väihkönen L, Heinonen O, Hyyppa S, Nieminen M, Pösö A. Lactate-transport activity in RBCs of trained and untrained individuals from four racing species. Am J Physiol Regul Integr Comp Physiol. 2001;281:R19-24 pubmed
    ..activity was measured at 10 and 30 mM concentrations, and the roles of the monocarboxylate-transporter (MCT) and the inorganic anion-exchange transporter (band-3 protein) were studied with inhibitors...
  85. Martel F, Guedes M, Keating E. Effect of polyphenols on glucose and lactate transport by breast cancer cells. Breast Cancer Res Treat. 2016;157:1-11 pubmed publisher
    ..Accordingly, GLUT1 and MCT1, which are the main glucose and lactate transporters in cancer cells, respectively, have been proposed as oncogenes ..
  86. Chen J, Cui X, Li L, Qu J, Raj J, Gou D. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Physiol Rep. 2017;5: pubmed publisher
    ..induced by PDGF-BB Finally, miR-339 expression was found to be decreased in the pulmonary arteries of rats with MCT-induced PAH Our study is the first report on the biological role of miR-339 in regulating proliferation of PASMC by ..
  87. De Saedeleer C, Porporato P, Copetti T, Perez Escuredo J, Payen V, Brisson L, et al. Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. Oncogene. 2014;33:4060-8 pubmed publisher
    ..Its activities primarily depend on its uptake, a process facilitated by the lactate-proton symporter monocarboxylate transporter 1 (MCT1)...
  88. Yan C, Yang F, Zhou C, Chen X, Han X, Liu X, et al. MCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer. Int J Clin Exp Pathol. 2015;8:2710-8 pubmed
    This study was designed to investigate the role of MCT1 in the development of cisplatin-resistant ovarian cancer and its possible relationship with Fas...
  89. Brockmeyer P, Kling A, Schulz X, Perske C, Schliephake H, Hemmerlein B. High mast cell density indicates a longer overall survival in oral squamous cell carcinoma. Sci Rep. 2017;7:14677 pubmed publisher
    ..Tryptase-positive (MCT+) and CD117-positive (CD117+) mast cells were immunohistochemically evaluated in tissue ..
  90. Bagi C, Edwards K, Berryman E. Metabolic Syndrome and Bone: Pharmacologically Induced Diabetes has Deleterious Effect on Bone in Growing Obese Rats. Calcif Tissue Int. 2018;102:683-694 pubmed publisher
    ..Cancellous bone structure and cortical bone geometry were evaluated by mCT and strength by the 3-point bending method...
  91. Cupeiro R, González Lamuño D, Amigo T, Peinado A, Ruiz J, Ortega F, et al. Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women. J Sci Med Sport. 2012;15:541-7 pubmed publisher
    To analyze the effect of the MCT1 T1470A polymorphism (rs1049434) on venous blood lactate levels in men and women, during three different circuit weight training protocols. Cross-sectional laboratory study...