MCM9

Summary

Gene Symbol: MCM9
Description: minichromosome maintenance 9 homologous recombination repair factor
Alias: C6orf61, MCMDC1, ODG4, dJ329L24.1, dJ329L24.3, DNA helicase MCM9, DNA replication licensing factor MCM9, mini-chromosome maintenance deficient domain-containing protein 1, minichromosome maintenance complex component 9
Species: human
Products:     MCM9

Top Publications

  1. Yoshida K. Identification of a novel cell-cycle-induced MCM family protein MCM9. Biochem Biophys Res Commun. 2005;331:669-74 pubmed
    ..Here we identified a novel MCM family gene, MCM9, by using bioinformatics. Human, mouse, and rat MCM9 showed approximately 90-91% total-amino acid identity...
  2. Lutzmann M, Maiorano D, Mechali M. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Gene. 2005;362:51-6 pubmed
    ..Here we report the complete identification of a novel member of this family, the MCM9 protein. Like MCM8, MCM9 is only present in the genome of higher eukaryotes...
  3. Maiorano D, Lutzmann M, Mechali M. MCM proteins and DNA replication. Curr Opin Cell Biol. 2006;18:130-6 pubmed
    ..by the identification of two additional members that appear to be present only in multicellular organisms, MCM8 and MCM9. The function of MCM8 is distinct from that of MCM2-7 proteins, while the function of MCM9 is unknown...
  4. Lutzmann M, Mechali M. MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. Mol Cell. 2008;31:190-200 pubmed publisher
    ..Here, we characterize MCM9, a member of the MCM2-8 family...
  5. Morii I, Iwabuchi Y, Mori S, Suekuni M, Natsume T, Yoshida K, et al. Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib. Cancer Sci. 2019;110:1044-1053 pubmed publisher
    MCM8 and MCM9 are paralogues of the MCM2-7 eukaryotic DNA replication helicase proteins and play a crucial role in a homologous recombination-mediated repair process to resolve replication stress by fork stalling...
  6. Yang X, Touraine P, Desai S, Humphreys G, Jiang H, Yatsenko A, et al. Gene variants identified by whole-exome sequencing in 33 French women with premature ovarian insufficiency. J Assist Reprod Genet. 2019;36:39-45 pubmed publisher
    ..The genes identified with pathogenic or likely pathogenic variants included PMM2, MCM9, and PSMC3IP...
  7. Dondik Y, Lei Z, Gaskins J, Pagidas K. Minichromosome maintenance complex component 8 and 9 gene expression in the menstrual cycle and unexplained primary ovarian insufficiency. J Assist Reprod Genet. 2019;36:57-64 pubmed publisher
    ..53, 0.90); and 0.65 in the ovulatory vs follicular phase (p = 0.0057, CI = 0.50, 0.85)]. No change in MCM9 expression was noted throughout the menstrual cycle...
  8. Gambus A, Blow J. Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation. Cell Cycle. 2013;12:1225-32 pubmed publisher
    ..Two other proteins, Mcm8 and Mcm9, with significant homology to Mcm2-7 were first shown to play distinct roles during DNA replication in Xenopus ..
  9. Goldberg Y, Halpern N, Hubert A, Adler S, Cohen S, Plesser Duvdevani M, et al. Mutated MCM9 is associated with predisposition to hereditary mixed polyposis and colorectal cancer in addition to primary ovarian failure. Cancer Genet. 2015;208:621-4 pubmed publisher
    Mutations in MCM9, which encodes DNA helicase, were recently shown to cause a clinical phenotype of primary ovarian failure and chromosomal instability...

More Information

Publications25

  1. Savci Heijink C, Halfwerk H, Koster J, van de Vijver M. A novel gene expression signature for bone metastasis in breast carcinomas. Breast Cancer Res Treat. 2016;156:249-59 pubmed publisher
    ..001, 95 % CI 1.54-5.00 in the independent set). The 15 genes, APOPEC3B, ATL2, BBS1, C6orf61, C6orf167, MMS22L, KCNS1, MFAP3L, NIP7, NUP155, PALM2, PH-4, PGD5, SFT2D2 and STEAP3, encoded mainly membrane-..
  2. Qin Y, Jiao X, Simpson J, Chen Z. Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update. 2015;21:787-808 pubmed publisher
    ..Synaptonemal complex central element 1 (SYCE1), minichromosome maintenance complex component 8 and 9 (MCM8, MCM9) and ATP-dependent DNA helicase homolog (HFM1) genes...
  3. Luo Y, Schimenti J. MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway. Genesis. 2015;53:678-84 pubmed publisher
    ..genetic studies of DDR pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9 (Mcm9), a gene that plays a role in homologous recombination repair (HRR)...
  4. Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson I, Kanemaki M. Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis. Genes Dev. 2017;31:816-829 pubmed publisher
    ..We propose that stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. ..
  5. Traver S, Coulombe P, Peiffer I, Hutchins J, Kitzmann M, Latreille D, et al. MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol Cell. 2015;59:831-9 pubmed publisher
    ..Here, we show that mammalian MCM9, a protein involved in replication and homologous recombination, forms a complex with MMR initiation proteins (MSH2,..
  6. Bouali N, Francou B, Bouligand J, Imanci D, Dimassi S, Tosca L, et al. New MCM8 mutation associated with premature ovarian insufficiency and chromosomal instability in a highly consanguineous Tunisian family. Fertil Steril. 2017;108:694-702 pubmed publisher
    ..participates in homologous recombination during meiosis and DNA double-stranded break repair by dimerizing with MCM9. Mcm8 knock out results in an early block in follicle development and small gonads...
  7. Wood Trageser M, Gurbuz F, Yatsenko S, Jeffries E, Kotan L, Surti U, et al. MCM9 mutations are associated with ovarian failure, short stature, and chromosomal instability. Am J Hum Genet. 2014;95:754-62 pubmed publisher
    ..genomic hybridization arrays, and whole-exome sequencing analyses identified homozygous pathogenic variants in MCM9, a gene implicated in homologous recombination and repair of double-stranded DNA breaks. In one family, the MCM9 c...
  8. Fauchereau F, Shalev S, Chervinsky E, Beck Fruchter R, Legois B, Fellous M, et al. A non-sense MCM9 mutation in a familial case of primary ovarian insufficiency. Clin Genet. 2016;89:603-7 pubmed publisher
    ..sequencing of the two patients and a non-affected sister allowed us to detect a homozygous causal variant in the MCM9 gene. The variant c.1483G>T [p...
  9. Nishimura K, Ishiai M, Horikawa K, Fukagawa T, Takata M, Takisawa H, et al. Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol Cell. 2012;47:511-22 pubmed publisher
    ..Here, we showed that the replicative helicase-related Mcm family of proteins, Mcm8 and Mcm9, forms a complex required for HR repair induced by ICLs...
  10. Jeffries E, Denq W, Denq W, Bartko J, Trakselis M. Identification, quantification, and evolutionary analysis of a novel isoform of MCM9. Gene. 2013;519:41-9 pubmed publisher
    ..b>MCM9 is an uncharacterized member of the eukaryotic MCM protein family that contains conserved ATP binding and ..
  11. Lutzmann M, Mechali M. How to load a replicative helicase onto chromatin: a more and more complex matter during evolution. Cell Cycle. 2009;8:1309-13 pubmed
    ..Recently, we characterized a new essential factor for pre-RC assembly and DNA licensing, the vertebrate-specific MCM9 protein that contains not only an ATPase but also a helicase domain...
  12. Desai S, Wood Trageser M, Matic J, Chipkin J, Jiang H, Bachelot A, et al. MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2017;102:576-582 pubmed publisher
    ..including biallelic pathogenic variants, in minichromosome maintenance 8 (MCM8) and minichromosome maintenance 9 (MCM9), other genes related to MCM8-MCM9, and DNA damage repair (DDR) pathway in participants with primary ovarian ..
  13. Liu Q, Hesson L, Nunez A, Packham D, Hawkins N, Ward R, et al. Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients. Cancer Genet. 2016;209:497-500 pubmed publisher
    ..b>MCM9 was recently identified as the DNA helicase in the mammalian MMR complex and loss of helicase activity results in ..
  14. Lee K, Im J, Shibata E, Park J, Handa N, Kowalczykowski S, et al. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun. 2015;6:7744 pubmed publisher
    ..Homozygous deletion of the MCM9 found in various cancers sensitizes a cancer cell line to interstrand-crosslinking (ICL) agents...
  15. Park J, Long D, Lee K, Abbas T, Shibata E, Negishi M, et al. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol. 2013;33:1632-44 pubmed publisher
    The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively...
  16. Liu Y, Richards T, Aves S. Ancient diversification of eukaryotic MCM DNA replication proteins. BMC Evol Biol. 2009;9:60 pubmed publisher
    ..In some eukaryotes Mcm8 and Mcm9 paralogues also appear to be involved in DNA replication although their exact roles are unclear...