Gene Symbol: MCM6
Description: minichromosome maintenance complex component 6
Alias: MCG40308, Mis5, P105MCM, DNA replication licensing factor MCM6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe), minichromosome maintenance deficient (mis5, S. pombe) 6
Species: human
Products:     MCM6

Top Publications

  1. Ishimi Y. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem. 1997;272:24508-13 pubmed
    ..Our group purified MCM protein complexes consisting of MCM2, -4 (Cdc21), -6 (Mis5), and -7 (CDC47) proteins from HeLa cells by using histone-Sepharose column chromatography (Ishimi, Y., Ichinose, S...
  2. Bell S, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem. 2002;71:333-74 pubmed
    ..We emphasize recent progress in determining the function of the different replication factors once they have been assembled at the origin. ..
  3. Yu Z, Feng D, Liang C. Pairwise interactions of the six human MCM protein subunits. J Mol Biol. 2004;340:1197-206 pubmed
    ..Thus, this study may serve as a foundation for understanding the overall architecture and function of eukaryotic MCM protein complexes and as clues for developing anticancer drugs targeted to the human MCM proteins. ..
  4. Tsuji T, Ficarro S, Jiang W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell. 2006;17:4459-72 pubmed
    ..Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. ..
  5. Teer J, Dutta A. Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication. J Biol Chem. 2008;283:6817-25 pubmed publisher
    ..These findings suggest that exogenous Cdt1 induces re-replication by de-repressing endogenous Cdt1 through the titration of PCNA and cyclin. ..
  6. Wei Z, Liu C, Wu X, Xu N, Zhou B, Liang C, et al. Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J Biol Chem. 2010;285:12469-73 pubmed publisher
    ..In this study, we demonstrate that the previously uncharacterized C-terminal domain of human Mcm6 is the Cdt1 binding domain (CBD) and present its high resolution NMR structure...
  7. Ishimi Y, Komamura Kohno Y, You Z, Omori A, Kitagawa M. Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. J Biol Chem. 2000;275:16235-41 pubmed
    ..These results raise the possibility that the inactivation of Mcm4,6,7 helicase activity by Cdk2 is a part of the system for regulating DNA replication. ..
  8. Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K. Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000;275:29042-52 pubmed
    ..MCM4 and MCM6 are also phosphorylated by huCdc7 albeit to less extent...
  9. Zhang J, Yu L, Wu X, Zou L, Sou K, Wei Z, et al. The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells. Cell Cycle. 2010;9:4848-57 pubmed
    ..Cdt1 physically interacts with the MCM complex, and this interaction mainly occurs between Cdt1 and Mcm6 in human cells...

More Information

Publications117 found, 100 shown here

  1. Yanagi K, Mizuno T, You Z, Hanaoka F. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem. 2002;277:40871-80 pubmed
    ..We found by yeast two-hybrid analysis that mouse Cdt1 associates with geminin, MCM6, and origin recognition complex 2...
  2. Sakwe A, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007;27:3044-55 pubmed
    ..The results indicate that multicellular eukaryotes contain two types of hexameric MCM complexes with unique properties and functions. ..
  3. Porraz G, Val A, Tribolo C, Mercier N, de la Peña P, Haaland M, et al. The MIS5 Pietersburg at '28' Bushman Rock Shelter, Limpopo Province, South Africa. PLoS ONE. 2018;13:e0202853 pubmed publisher 73±6ka and 75±6ka on quartz and to 91±10ka and 97±10ka on feldspar, firmly positioning this industry within MIS5. Comparisons with other published lithic assemblages show technological differences between the Pietersburg from ..
  4. Pierre C, Agopiantz M, Brunaud L, Battaglia Hsu S, Max A, Pouget C, et al. COPPS, a composite score integrating pathological features, PS100 and SDHB losses, predicts the risk of metastasis and progression-free survival in pheochromocytomas/paragangliomas. Virchows Arch. 2019;: pubmed publisher
    ..0001) and shorter PFS (P = 0.013). In addition, both MCM6 and Ki-67 LI correlated with worse PFS (P = 0.004 and P < 0...
  5. Loftus E, Lee Thorp J, Leng M, Marean C, Sealy J. Seasonal scheduling of shellfish collection in the Middle and Later Stone Ages of southern Africa. J Hum Evol. 2019;128:1-16 pubmed publisher
    ..The Pinnacle Point 5-6 assemblage, which spans the MIS5-4 transition, records a marked shift in shellfishing seasonality at c...
  6. Dabral P, Uppal T, Rossetto C, Verma S. Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication. J Virol. 2019;93: pubmed publisher
    ..MCM3 and -4 of the MCM complex specifically bound to the amino-terminal domain, while MCM6 bound to both the amino- and carboxyl-terminal domains of LANA...
  7. Exposito F, Villalba M, Redrado M, de Aberasturi A, Cirauqui C, Redin E, et al. Targeting of TMPRSS4 sensitizes lung cancer cells to chemotherapy by impairing the proliferation machinery. Cancer Lett. 2019;453:21-33 pubmed publisher
    ..Transcriptomic analysis in KD cells revealed downregulation of genes involved in DNA replication, such as MCM6, TYMS and CDKN1A (p21)...
  8. Qi D, Wu B, Tong D, Pan Y, Chen W. Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data. Mol Med Rep. 2015;12:2570-6 pubmed publisher
    ..complex component 7 (Mcm7); lymphoid-specific helicase (Hells); and minichromosome maintenance complex component 6 (Mcm6), that function in the unwinding of DNA were identified to participate in Mist1KO pancreatitis...
  9. Huang R, Shu S, Liu M, Wang C, Jiang B, Jiang J, et al. Nuclear Prohibitin3 Maintains Genome Integrity and Cell Proliferation in the Root Meristem through Minichromosome Maintenance 2. Plant Physiol. 2019;179:1669-1691 pubmed publisher
    ..g. MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7, are up-regulated in the phb3 mutant...
  10. Liao X, Han C, Wang X, Huang K, Yu T, Yang C, et al. Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy. Cancer Manag Res. 2018;10:3255-3271 pubmed publisher
    ..Through mining public databases, we observed that MCM genes (MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7) were upregulated in pancreatic cancer tumor tissue and have a strong positive coexpression ..
  11. Wang R, Lin Y, Jin Q, Yao C, Zhong Y, Wu T. RNA-Seq analysis of gynoecious and weak female cucumber revealing the cell cycle pathway may regulate sex determination in cucumber. Gene. 2019;687:289-297 pubmed publisher
    ..These genes included Cs-MCM6, Cs-ACT3, Cs-XRCC4, Cs-MCM2, Cs-CDC45, Cs-Dpri, Cs-H2B, Cs-CDC20 and Cs-CNGC1...
  12. Leturcq M, Mortuaire M, Hardiville S, Schulz C, Lefebvre T, Vercoutter Edouart A. O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions. Cell Mol Life Sci. 2018;75:4321-4339 pubmed publisher
    ..We previously reported the O-GlcNAcylation of the minichromosome maintenance proteins MCM2, MCM3, MCM6 and MCM7...
  13. Strahan R, Dabral P, Dingman K, Stadler C, Hiura K, Verma S. Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59. J Virol. 2018;92: pubmed publisher
    ..confirmed in both endogenous and overexpression systems, which showed its association with MCM3, MCM4, MCM5, and MCM6. Interestingly, MCM6 interacted with both the N- and C-terminal domains of ORF59, and its depletion in BCBL-1 and ..
  14. Lerchbaum E, Giuliani A, Gruber H, Pieber T, Obermayer Pietsch B. Adult-type hypolactasia and calcium intake in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77:834-43 pubmed publisher
    ..Genotyping of ATH, defined by the -13910 variant of the MCM6 gene, was performed. Calcium intake was assessed by questionnaires...
  15. Bruck I, Pérez Arnaiz P, Colbert M, Kaplan D. Insights into the Initiation of Eukaryotic DNA Replication. Nucleus. 2015;6:449-54 pubmed publisher
    ..DDK, on the other hand, phosphorylates the Mcm2, Mcm4, and Mcm6 subunits of the Mcm2-7 complex...
  16. Cai H, Cheng Z, Zhang H, Wang P, Zhang Y, Hao J, et al. Overexpression of MCM6 predicts poor survival in patients with glioma. Hum Pathol. 2018;78:182-187 pubmed publisher
    ..we analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas and found that MCM6 presented high expression and was associated with poor survival...
  17. Sincennes M, Humbert M, Grondin B, Lisi V, Veiga D, Haman A, et al. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc Natl Acad Sci U S A. 2016;113:1393-8 pubmed publisher
    ..with three essential replication enzymes: DNA polymerase delta (POLD1), DNA primase (PRIM1), and minichromosome 6 (MCM6)...
  18. Horn S, Kirkegaard J, Hoelper S, Seymour P, Rescan C, Nielsen J, et al. Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo. Mol Endocrinol. 2016;30:133-43 pubmed publisher
    ..included several proteins, not previously associated with pregnancy-induced islet expansion, such as CLIC1, STMN1, MCM6, PPIB, NEDD4, and HLTF...
  19. Nie Y, Lang T. The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells. Pharmazie. 2017;72:670-673 pubmed publisher
    ..tagged ATRIP (Myc-, hemaglutinin (HA) or Flag) and minichromosome maintenance (MCM) complex (MCM2, MCM3, MCM5, and MCM6) were transfected into 293T cells. After 48 h, ATRIP-interacting protein was identified by mass spectrometry (MS)...
  20. Duro E, Lundin C, Ask K, Sanchez Pulido L, MacArtney T, Toth R, et al. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010;40:632-44 pubmed publisher
    ..Therefore, MMS22L and TONSL are required for the maintenance of genome stability when unscheduled DSBs occur in the vicinity of DNA replication forks. ..
  21. Chiu C, Jackson K, Hearn N, Steiner N, Head G, Lind J. Identification of genes with altered expression in male and female Schlager hypertensive mice. BMC Med Genet. 2014;15:101 pubmed publisher
    ..Genes involved in sympathetic activity (Hdc, Cndp2), vascular ageing (Edn3), and telomere maintenance (Mcm6) were identified as being differentially expressed between BPH/2J and BPN/3J comparisons...
  22. Löffler K, Schäfer P, Völkner M, Holdt T, Karl M. Age-dependent Müller glia neurogenic competence in the mouse retina. Glia. 2015;63:1809-24 pubmed publisher
    ..In EGF-stimulated juvenile postmitotic retinas, most MG upregulate cell-cycle regulators (Mcm6, Pcna, Ki67, Ccnd1) within 48 h ex vivo; some also express the neurogenic factors Ascl1, Pax6, and Vsx2; up to 60% ..
  23. Huang J, Luo H, Pan H, Qiu C, Hao T, Zhu Z. Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells. Biochemistry (Mosc). 2018;83:69-75 pubmed publisher
    ..The results showed that RAD51 directly interacted with MCM2, MCM3, MCM5, and MCM6 in colon cancer HTC116 cells...
  24. Suman S, Mishra A. An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia. Sci Rep. 2018;8:12927 pubmed publisher
    ..DEGs namely NDC80, ZWINT, CDC7, MCM4, MCM2 and MCM6 were found to be common in both the significant modules as well as the hubs...
  25. Wu X, Ruan L, Yang Y, Mei Q. Identification of crucial regulatory relationships between long non-coding RNAs and protein-coding genes in lung squamous cell carcinoma. Mol Cell Probes. 2016;30:146-52 pubmed publisher
    ..PVT1 targeted genes related to cell cycle (e.g. POLA2, POLD1, MCM4, MCM5 and MCM6), and reduced expression of PVT1 decreased expression of the genes. TERC regulated several genes (e.g...
  26. Liu Z, Li J, Chen J, Shan Q, Dai H, Xie H, et al. MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression. BMC Cancer. 2018;18:200 pubmed publisher
    ..Elevated MCM2, MCM6 and MCM7 were associated with adverse tumor features and poorer outcomes...
  27. Tatsumi R, Ishimi Y. An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation. J Biochem. 2017;161:259-268 pubmed publisher
    ..Role of the conserved amino acid in MCM4 function is discussed. ..
  28. Armstrong A. Small mammal utilization by Middle Stone Age humans at Die Kelders Cave 1 and Pinnacle Point Site 5-6, Western Cape Province, South Africa. J Hum Evol. 2016;101:17-44 pubmed publisher
    ..In comparison, the MIS5-4 humans at PP5-6 did not exploit small mammals and instead focused on higher-quality resources like shellfish and ..
  29. Douglas M, Diffley J. Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem. 2016;291:5879-88 pubmed publisher
    ..Moreover, the binding site for Mcm10 on MCM includes the Mcm2 and Mcm6 subunits and overlaps that for the loading factor Cdt1...
  30. Martinez Noel G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan J, et al. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018;430:1024-1050 pubmed publisher
    ..In addition to finding new UBE3A-associated proteins, such as MCM6, SUGT1, EIF3C, and ASPP2, network analysis revealed that UBE3A-associated proteins are connected to several ..
  31. Wagner S, Oehler H, Voigt A, Dalic D, Freiwald A, Serve H, et al. ATR inhibition rewires cellular signaling networks induced by replication stress. Proteomics. 2016;16:402-16 pubmed publisher
    ..the ATR-dependent phosphorylation following replication stress and discover novel putative ATR target sites on MCM6, TOPBP1, RAD51AP1, and PSMD4...
  32. Tolkach Y, Merseburger A, Herrmann T, Kuczyk M, Serth J, Imkamp F. Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer. Anticancer Res. 2015;35:5443-51 pubmed
    ..2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ..
  33. Chen Y, Weng C, Zhang H, Sun J, Yuan Y. A Direct Interaction Between P53-Binding Protein 1 and Minichromosome Maintenance Complex in Hepg2 Cells. Cell Physiol Biochem. 2018;47:2350-2359 pubmed publisher
    ..Moreover, the expressions of MCM2 and MCM6 were suppressed by specific short hairpin RNAs (shRNAs), and then the chromatin fraction and foci formation of ..
  34. Rots V, Lentfer C, Schmid V, Porraz G, Conard N. Pressure flaking to serrate bifacial points for the hunt during the MIS5 at Sibudu Cave (South Africa). PLoS ONE. 2017;12:e0175151 pubmed publisher
  35. Triska P, Soares P, Patin E, Fernandes V, Cerny V, Pereira L. Extensive Admixture and Selective Pressure Across the Sahel Belt. Genome Biol Evol. 2015;7:3484-95 pubmed publisher
    ..The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-..
  36. Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, et al. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. Biochim Biophys Acta. 2014;1843:2432-7 pubmed publisher
    ..b>MCM6 and TSG101 tumor-associated markers were also decreased...
  37. Yao C, Joehanes R, Johnson A, Huan T, Liu C, Freedman J, et al. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017;100:571-580 pubmed publisher
    ..and fasting blood glucose) and identified several cis-eGenes (ALDH2 for systolic and diastolic blood pressure, MCM6 and DARS for total cholesterol, and TRIB1 for triglycerides) that were causal mediators for the corresponding ..
  38. Huang X, Xu M, Zhang W, Ma S, Guo W, Wang Y, et al. ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells. Nanoscale Res Lett. 2017;12:322 pubmed publisher
    ..blot assay further confirmed that anti-ICAM-T0901317 liposomes inhibited retinoblastoma (Rb) phosphorylation and MCM6 expression...
  39. You Z, Komamura Y, Ishimi Y. Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. Mol Cell Biol. 1999;19:8003-15 pubmed
    ..Recently, we reported that a DNA helicase activity is associated with an Mcm4-Mcm6-Mcm7 (Mcm4,6,7) complex, suggesting that this complex is involved in the initiation of DNA replication as a DNA-..
  40. Yu J, Wang R, Wu J, Dang Z, Zhang Q, Li B. Knockdown of Minichromosome Maintenance Proteins Inhibits Foci Forming of Mediator of DNA-Damage Checkpoint 1 in Response to DNA Damage in Human Esophageal Squamous Cell Carcinoma TE-1 Cells. Biochemistry (Mosc). 2016;81:1221-1228 pubmed
    ..MCM2 and MCM6 were knocked down by shRNAs, after which chromatin fraction and foci forming of MDC1 upon bleomycin-induced DNA ..
  41. Lukito W, Malik S, Surono I, Wahlqvist M. From 'lactose intolerance' to 'lactose nutrition'. Asia Pac J Clin Nutr. 2015;24 Suppl 1:S1-8 pubmed publisher
    ..people have the T single nucleotide polymorphism (SNP) of the rs49882359 allele (C/T), also known as C/T-13910, the MCM6 gene which positively influences the lactase LCT gene...
  42. Zhai Y, Cheng E, Wu H, Li N, Yung P, Gao N, et al. Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer. Nat Struct Mol Biol. 2017;24:300-308 pubmed publisher
    ..Cdt1 wraps around the N-terminal regions of Mcm2, Mcm6 and Mcm4 to stabilize the whole complex...
  43. Tan B, Chien C, Hirose S, Lee S. Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006;25:3975-85 pubmed
  44. Larasati -, Duncker B. Mechanisms Governing DDK Regulation of the Initiation of DNA Replication. Genes (Basel). 2016;8: pubmed publisher
    ..Numerous investigations have determined mechanistic details, including the regions of Mcm2, Mcm4, and Mcm6 phosphorylated by DDK, and a number of DDK docking sites...
  45. Enattah N, Sahi T, Savilahti E, Terwilliger J, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet. 2002;30:233-7 pubmed
    ..That the variant (C/T-13910) occurs in distantly related populations indicates that it is very old. ..
  46. Liu M, Hu Q, Tu M, Wang X, Yang Z, Yang G, et al. MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence. J Exp Clin Cancer Res. 2018;37:10 pubmed publisher
    ..Minichromosome maintenance complex component 6 (MCM6), which has been reported to up-regulate in multiple malignancies, was considered to be a novel diagnoses biomarker ..
  47. Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon K, et al. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Nucleic Acids Res. 2000;28:4769-77 pubmed
    ..HsMcm10 also interacted with Orc2, Mcm2 and Mcm6 proteins in the yeast two-hybrid system...
  48. Clarke C, Clarke P. DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J. 2005;388:705-12 pubmed
    ..This cell-free system will facilitate further biochemical analysis of the Chk1 pathway in humans. ..
  49. Imtiaz F, Savilahti E, Sarnesto A, Trabzuni D, Al Kahtani K, Kagevi I, et al. The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population. J Med Genet. 2007;44:e89 pubmed
    ..the previously identified lactase persistence/non-persistence variant C/T-13910 residing in intron 13 of the MCM6 gene. Two anonymous blood donors carried the C/T-13910 genotype...
  50. Vijayraghavan S, Schwacha A. The eukaryotic Mcm2-7 replicative helicase. Subcell Biochem. 2012;62:113-34 pubmed publisher
  51. Deegan T, Yeeles J, Diffley J. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J. 2016;35:961-73 pubmed publisher
    ..Moreover, phosphomimicking mutants in Mcm4 and Mcm6 bind Sld3 without DDK and facilitate DDK-independent replication...
  52. Chang Y, Huang H, Yeh K, Chang J. Identification of novel mutations in endometrial cancer patients by whole-exome sequencing. Int J Oncol. 2017;50:1778-1784 pubmed publisher
    ..Our results revealed nine potential driver genes (MAPT, IL24, MCM6, TSC1, BIRC2, CIITA, DST, CASP8 and NOTCH2) and 21 potential passenger genes (ARMCX4, IGSF10, VPS13C, DCT, DNAH14, ..
  53. Vigouroux C, Casse J, Battaglia Hsu S, Brochin L, Luc A, Paris C, et al. Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma. Lung Cancer. 2015;89:189-96 pubmed publisher analyze the expression of HuR in a series of NSCLC and to correlate this to two proliferation markers, Ki-67 and MCM6. As potential post-transcriptional regulatory mechanisms for HuR expression, two miRNAs, miR16 and miR519, were ..
  54. Zhang W, Liang Z, Li J. Inhibition of rhotekin exhibits antitumor effects in lung cancer cells. Oncol Rep. 2016;35:2529-34 pubmed publisher
    ..and that the DNA replication initiation complex proteins Minichromosome maintenance protein complex (MCM)2 and MCM6 were decreased as well in RTKN knock-down cells...
  55. Cheng X, Xu C, DeGiorgio M. Fast and robust detection of ancestral selective sweeps. Mol Ecol. 2017;: pubmed publisher
    ..The MCM6/LCT cluster and the SLC45A2 and HERC2 genes are strong outliers, agreeing with previous studies...
  56. Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, et al. Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat Struct Mol Biol. 2017;24:316-324 pubmed publisher
    ..A three-domain Cdt1 configuration embraces Mcm2, Mcm4, and Mcm6, thus comprising nearly half of the hexamer...
  57. Li M, Maruthur N, Loomis S, Pietzner M, North K, Mei H, et al. Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism. Sci Rep. 2017;7:2812 pubmed publisher
    ..Seven loci in/near EFNA1/SLC50A1, MCM6/LCT, SI, MGAM, MGAM2, SLC5A10, and SLC5A1 showed genome-wide significant associations (P < 5 × 10-..
  58. Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, et al. Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Genes Cells. 2003;8:413-21 pubmed
    ..GST(glutathione S-transferase)-pull down and two hybrid experiments suggest that a putative Mcm6-Mcm6 hinge contributes to the formation of the Mcm7/4/6/6/4/7 heterohexamer...
  59. Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, et al. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acids Res. 2013;41:10312-22 pubmed publisher
    ..Moreover, we observed that MSH2 can facilitate TLS across cyclobutane pyrimidine dimers photoproducts in living cells, presenting a novel role of MSH2 in post-UV cellular responses. ..
  60. Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H. Binding of human minichromosome maintenance proteins with histone H3. J Biol Chem. 1996;271:24115-22 pubmed
    ..We detected in HeLa cell extracts six proteins, CDC47, CDC46/MCM5, Cdc21, P1/MCM3, Mis5, and BM28/MCM2, by their binding to a specific antibody and by partial sequencing...
  61. Ryu M, Kim B, Lee J, Lee M, Choi H, Kim S. Direct interaction between cohesin complex and DNA replication machinery. Biochem Biophys Res Commun. 2006;341:770-5 pubmed
    ..Interestingly, we also discovered that Smc1 interacts with other DNA replication proteins, including Mcm6, RFC1, and DNA polymerase alpha...
  62. Smith G, Lawlor D, Timpson N, Baban J, Kiessling M, Day I, et al. Lactase persistence-related genetic variant: population substructure and health outcomes. Eur J Hum Genet. 2009;17:357-67 pubmed publisher
    ..19 (0.87, 1.64). The lactase persistence variant could contribute to the examination of data for the existence of, and then statistical control for, population substructure in genetic association studies. ..
  63. Jasencakova Z, Scharf A, Ask K, Corpet A, Imhof A, Almouzni G, et al. Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell. 2010;37:736-43 pubmed publisher
    ..During recovery, histones stored with Asf1 are rapidly used as replication resumes. This shows that replication stress interferes with predeposition marking and histone recycling with potential impact on epigenetic stability. ..
  64. Jagannathan M, Nguyen T, Gallo D, Luthra N, Brown G, Saridakis V, et al. A role for USP7 in DNA replication. Mol Cell Biol. 2014;34:132-45 pubmed publisher
    ..This role of USP7 mirrors the previously described role for MCM-BP in MCM complex unloading and suggests that USP7 works with MCM-BP to unload MCM complexes from chromatin at the end of S phase. ..
  65. Liu Y, Wang B, Jiang Y, Cao J, Hao J, Zhang Y, et al. MCMs expression in lung cancer: implication of prognostic significance. J Cancer. 2017;8:3641-3647 pubmed publisher
    ..We evaluated the expression of MCM2, MCM5 and MCM6 immunohistochemically in 571 primary NSCLC samples. High expression of MCM2, MCM5 and MCM6 was detected in 42...
  66. You Z, Ishimi Y, Masai H, Hanaoka F. Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J Biol Chem. 2002;277:42471-9 pubmed
    ..In conjunction with the previously reported essential role of Mcm6 in ATP binding (You, Z., Komamura, Y., and Ishimi, Y. (1999) Mol. Cell. Biol...
  67. Xu J, Zhang S, You C, Huang S, Cai B, Wang X. Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol. 2007;83:183-9 pubmed
    ..tumors were collected and immunohistochemical analysis of the expression of minichromosome maintenance protein 6 (MCM6) and DNA topoisomerase II alphalpha (DNA Topo II alpha) in the tumor sections was performed by quantitative ..
  68. O Connell B, Adamson B, Lydeard J, Sowa M, Ciccia A, Bredemeyer A, et al. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010;40:645-57 pubmed publisher
    ..This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway and provides a resource for discovery of additional components of this pathway. ..
  69. Gurvich N, Perna F, Farina A, Voza F, Menendez S, Hurwitz J, et al. L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci U S A. 2010;107:22552-7 pubmed publisher
    ..We propose that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability. ..
  70. Boxus M, Twizere J, Legros S, Kettmann R, Willems L. Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program. Blood. 2012;119:151-60 pubmed publisher
    ..Mechanistically, Tax favors p300 recruitment and histone hyperacetylation at late replication domains, advancing their replication timing in early S phase. ..
  71. Magiera R, Schürer Maly C, Mortsiefer A, Abholz H, Maly F, Pentzek M. Are there differences between patients with and without the homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase gene?--A non-randomised, two armed intervention study without control group. Clin Lab. 2014;60:1617-25 pubmed
    ..For the LI-group, this could be explained by an unspecific effect of a diet in general, e.g., getting special attention. This can be important for a group of patients probably having psychosomatic complaints focussed on the abdomen. ..
  72. Tsuruga H, Yabuta N, Hosoya S, Tamura K, Endo Y, Nojima H. HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5. Genes Cells. 1997;2:381-99 pubmed
    ..We report here the structural and functional analyses of HsMcm6, a human homologue of the Mis5 of Schizosaccharomyces pombe...
  73. Holthoff H, Baack M, Richter A, Ritzi M, Knippers R. Human protein MCM6 on HeLa cell chromatin. J Biol Chem. 1998;273:7320-5 pubmed
    ..the primary structures of five human Mcm proteins, but the primary structure of the sixth human Mcm protein, MCM6, was identified only recently...
  74. Johnson E, Kinoshita Y, Daniel D. A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. Nucleic Acids Res. 2003;31:2915-25 pubmed
    The MCM8 protein from HeLa cells, a new member of the MCM family, co-isolates through several steps with MCM6 and MCM7, and MCM8 co-immunoprecipitates with MCM4, MCM6 and MCM7, proteins reportedly forming a helicase complex involved in ..
  75. Pires I, Bencokova Z, Milani M, Folkes L, Li J, Stratford M, et al. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res. 2010;70:925-35 pubmed publisher
    ..chronic hypoxia, we found that replicative restart was inhibited along with numerous replication factors, including MCM6 and RPA, the latter of which limits the hypoxia-induced DNA damage response...
  76. Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J. 2012;31:2013-23 pubmed publisher
    ..This function is compromised by two CDAI mutations that impair complex formation with Asf1, providing insight into the molecular basis for CDAI disease. ..
  77. Fujita M, Kiyono T, Hayashi Y, Ishibashi M. In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J Biol Chem. 1997;272:10928-35 pubmed
    ..Nuclease digestion-immunoprecipitation techniques of the type described here should facilitate further elucidation of the mode of interaction between hMCMs and chromatin. ..
  78. Xu J, You C, Wang X, Shuai K, Wang X. [Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007;38:64-7 pubmed
    To investigate the expression of minichromosome maintenance protein 6 (MCM6) in tissue sections of craniopharyngioma and observe its relation with the outcome of patients with craniopharyngiomas...
  79. Souza Rodrígues E, Estanyol J, Friedrich Heineken E, Olmedo E, Vera J, Canela N, et al. Proteomic analysis of p16ink4a-binding proteins. Proteomics. 2007;7:4102-11 pubmed
    ..identification of two of them, proliferating cell nuclear antigen (PCNA) and minichromosome maintenance protein 6 (MCM6), was confirmed by Western blotting and their in vivo interactions with p16(ink4a) were demonstrated by ..
  80. Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
    ..Thus, in addition to SCF(Skp2) and cullin4-based ubiquitin ligases, APC/C(Cdh1) is a third ubiquitin ligase that plays a crucial role in proteolytic regulation of Cdt1 in mammalian cells. ..
  81. Nguyen T, Jagannathan M, Shire K, Frappier L. Interactions of the human MCM-BP protein with MCM complex components and Dbf4. PLoS ONE. 2012;7:e35931 pubmed publisher
    ..Since DDK is known to activate DNA replication through phosphorylation of these MCM proteins, our results suggest that MCM-BP may affect DNA replication in part by regulating MCM phosphorylation by DDK. ..
  82. Yang Q, Lin S, Au Yeung S, Kwok M, Xu L, Leung G, et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr. 2017;71:1008-1012 pubmed publisher
    ..Instrumental variable analysis based on a genetic variant endowing lactase persistence (rs4988235 (MCM6)) was used to obtain estimates for osteoporosis (GEFOS), IHD (CARDIoGRAMplusC4D), T2D (DIAGRAM), adiposity (GIANT), ..
  83. Tishkoff S, Reed F, Ranciaro A, Voight B, Babbitt C, Silverman J, et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet. 2007;39:31-40 pubmed
    ..These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits-animal domestication and adult milk consumption. ..
  84. Ingram C, Raga T, Tarekegn A, Browning S, Elamin M, Bekele E, et al. Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group. J Mol Evol. 2009;69:579-88 pubmed publisher
    ..The SNPs are located in an 'enhancer' sequence in an intron of a neighboring gene (MCM6) and modulate lactase transcription in vitro...
  85. Piwko W, Olma M, Held M, Bianco J, Pedrioli P, Hofmann K, et al. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J. 2010;29:4210-22 pubmed publisher
    ..Together, our results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. ..
  86. Herbig U, Marlar C, Fanning E. The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. Mol Biol Cell. 1999;10:2631-45 pubmed
    ..Microinjection of either mutant protein into human cells in G1 inhibited DNA replication, suggesting that ATP binding and hydrolysis by HsCdc6 are essential for DNA replication. ..
  87. Saade E, Mechold U, Kulyyassov A, Vertut D, Lipinski M, Ogryzko V. Analysis of interaction partners of H4 histone by a new proteomics approach. Proteomics. 2009;9:4934-43 pubmed publisher
    ..Finally, we show that HAT1 requires N-terminal tail of H4 for its stable association with this histone. ..
  88. Liu C, Wu R, Zhou B, Wang J, Wei Z, Tye B, et al. Structural insights into the Cdt1-mediated MCM2-7 chromatin loading. Nucleic Acids Res. 2012;40:3208-17 pubmed publisher
    ..To elucidate the molecular mechanism of this event, we determined the structure of the human Cdt1-Mcm6 binding domains, the Cdt1(410-440)/MCM6(708-821) complex by NMR...
  89. Liccardi G, Hartley J, Hochhauser D. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin Cancer Res. 2014;20:3496-506 pubmed publisher
    ..These data emphasize the importance of understanding the various mechanisms by which EGFR modulates DNA repair to optimize targeted therapy for patients with cancer. ..
  90. Cavelier P, Cau J, Morin N, Delsert C. Early gametogenesis in the Pacific oyster: new insights using stem cell and mitotic markers. J Exp Biol. 2017;220:3988-3996 pubmed publisher
    ..In addition, the binding of the minichromosome maintenance MCM6 protein to chromatin indicated the gonad acini and duct cells were engaged in the cell cycle...
  91. Zhong H, Chen B, Neves H, Xing J, Ye Y, Lin Y, et al. Expression of minichromosome maintenance genes in renal cell carcinoma. Cancer Manag Res. 2017;9:637-647 pubmed publisher
    ..Expression levels of MCM2, MCM5, MCM6, and MCM7, but not of MCM3 and MCM4, were higher in RCC compared to paired adjacent normal tissue...
  92. Harvey C, Wang Y, Darmoul D, Phillips A, Mantei N, Swallow D. Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21. FEBS Lett. 1996;398:135-40 pubmed
    Four exons of a human homologue of a yeast cell division cycle gene (MCM6/mis5, which is thought to encode a DNA replication licensing factor) have been identified 3...