Gene Symbol: MCM3
Description: minichromosome maintenance complex component 3
Alias: HCC5, P1-MCM3, P1.h, RLFB, DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, MCM3 minichromosome maintenance deficient 3, RLF subunit beta, cervical cancer proto-oncogene 5, hRlf beta subunit, minichromosome maintenance deficient 3, p102, replication licensing factor, beta subunit
Species: human
Products:     MCM3

Top Publications

  1. Lee Y, Ha S, Kim H, Shin S, Kim H, Kim S, et al. Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. Exp Mol Pathol. 2010;88:138-42 pubmed publisher
    ..Minichromosome maintenance protein 3 (MCM3) is known to have a role on the initiation and regulation of DNA replication during cell cycle...
  2. Hubbi M, Luo W, Baek J, Semenza G. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011;42:700-12 pubmed publisher
    ..b>MCM3 inhibits transactivation domain function, whereas MCM7 enhances HIF-1? ubiquitination and proteasomal degradation...
  3. Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K. Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem. 2000;275:29042-52 pubmed
    ..In vitro, Cdk2-Cyclin E, Cdk2-Cyclin A, and Cdc2-Cyclin B, but not Cdk4-Cyclin D1, phosphorylates the Thr-376 residue of huCdc7, suggesting possible regulation of huCdc7 by Cdks. ..
  4. Cortez D, Glick G, Elledge S. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A. 2004;101:10078-83 pubmed
    ..First, ATM phosphorylates MCM3 on S535 in response to ionizing radiation...
  5. Tsuji T, Ficarro S, Jiang W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell. 2006;17:4459-72 pubmed
    ..Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. ..
  6. Sakwe A, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007;27:3044-55 pubmed
    ..MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2; and, conversely, hexameric complexes of MCM2 to MCM7 lacked MCM-BP, indicating that ..
  7. Kobierzycki C, Pula B, Skiba M, Jablonska K, Latkowski K, Zabel M, et al. Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer. Anticancer Res. 2013;33:5375-83 pubmed
    ..I+II; p=0.0247). Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered. ..
  8. Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol. 2000;20:8602-12 pubmed
    ..Loading of hMcm proteins onto chromatin occurs in late mitosis concomitant with the destruction of cyclin B, indicating that the mitotic kinase activity inhibits prereplication complex formation in human cells. ..
  9. Yu Z, Feng D, Liang C. Pairwise interactions of the six human MCM protein subunits. J Mol Biol. 2004;340:1197-206 pubmed
    ..Thus, this study may serve as a foundation for understanding the overall architecture and function of eukaryotic MCM protein complexes and as clues for developing anticancer drugs targeted to the human MCM proteins. ..

More Information

Publications127 found, 100 shown here

  1. Ha S, Shin S, Namkoong H, Lee H, Cho G, Hur S, et al. Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. Clin Cancer Res. 2004;10:8386-95 pubmed
    ..We identified a minichromosome maintenance 3 (MCM3) gene that was overexpressed in various human cancers, including leukemia, lymphoma, and carcinomas of the uterine ..
  2. Söling A, Sackewitz M, Volkmar M, Schaarschmidt D, Jacob R, Holzhausen H, et al. Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. Clin Cancer Res. 2005;11:249-58 pubmed
    ..of one of the identified antigens, the replication licensing factor minichromosome maintenance protein 3 (MCM3), was analyzed by immunohistochemistry in 142 primary and 27 recurrent astrocytomas (WHO grades 2-4)...
  3. Nodin B, Fridberg M, Jonsson L, Bergman J, Uhlen M, Jirstrom K. High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma. Diagn Pathol. 2012;7:82 pubmed publisher
    ..ovarian cancer, an inverse association was found between expression of RBM3 and the minichromosome maintenance 3 (MCM3) gene and protein...
  4. Bell S, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem. 2002;71:333-74 pubmed
    ..We emphasize recent progress in determining the function of the different replication factors once they have been assembled at the origin. ..
  5. Lau K, Chan Q, Pang J, Li K, Yeung W, Chung N, et al. Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion. Oncogene. 2010;29:5475-89 pubmed publisher
    ..In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinical samples...
  6. Zhou J, Chau C, Deng Z, Shiekhattar R, Spindler M, Schepers A, et al. Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J. 2005;24:1406-17 pubmed
    ..H3 acetylation of DS-bounded nucleosomes decreased during late G1, coinciding with nucleosome remodeling and MCM3 loading, and preceding the onset of DNA replication...
  7. Vachon C, Li J, Scott C, Hall P, Czene K, Wang X, et al. No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density. Breast Cancer Res. 2012;14:R7 pubmed the putative locus, LOC375190, Aurora B kinase (AURKB), and Mini-chromosome maintenance complex component 3 (MCM3) with adjusted PMD, although these were not statistically significant...
  8. Rizvi I, Choudhury N, Tuteja N. Arabidopsis thaliana MCM3 single subunit of MCM2-7 complex functions as 3' to 5' DNA helicase. Protoplasma. 2016;253:467-75 pubmed publisher
    ..Here, we present the biochemical characterization of Arabidopsis thaliana MCM3 single subunit and show that it exhibits in vitro unwinding and ATPase activities...
  9. Carreón Burciaga R, González González R, Molina Frechero N, Bologna Molina R. Immunoexpression of Ki-67, MCM2, and MCM3 in Ameloblastoma and Ameloblastic Carcinoma and Their Correlations with Clinical and Histopathological Patterns. Dis Markers. 2015;2015:683087 pubmed publisher was to analyze the presence of Ki-67 protein and the minichromosome maintenance-2 (MCM2) and maintenance-3 (MCM3) proteins in ameloblastoma. Materials and Methods...
  10. Zhuang L, Yang Z, Meng Z. Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients. Biomed Res Int. 2018;2018:7897346 pubmed publisher
    ..GSE17548, 13 genes including BUB1B, CCNA2, CCNB1, CCNE2, CDC20, CDC6, CDC7, CDK1, CDK4, CDKN2A, CHEK1, MAD2L1, and MCM3 in cell cycle pathway were shared in the three databases for enrichment...
  11. Yamamoto K, Makino N, Nagai M, Araki H, Ushimaru T. CDK phosphorylation regulates Mcm3 degradation in budding yeast. Biochem Biophys Res Commun. 2018;506:680-684 pubmed publisher
    ..kinase (CDK) negatively regulates nuclear localization of the MCM complex via phosphorylation of the Mcm3 subunit...
  12. Subramanian C, Cohen M. Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma. Surgery. 2019;165:202-210 pubmed publisher
    ..and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05)...
  13. Alvarez S, Diaz M, Flach J, Rodriguez Acebes S, López Contreras A, Martinez D, et al. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548 pubmed publisher
    ..b>Mcm3-deficient erythroblasts display aberrant DNA replication patterns and fail to complete maturation, causing lethal ..
  14. Huang J, Luo H, Pan H, Qiu C, Hao T, Zhu Z. Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells. Biochemistry (Mosc). 2018;83:69-75 pubmed publisher
    ..The results showed that RAD51 directly interacted with MCM2, MCM3, MCM5, and MCM6 in colon cancer HTC116 cells...
  15. Song Y, Stinski M. Human cytomegalovirus IE86 protein binds to cellular Mcm3 protein but does not inhibit its binding to the Epstein-Barr virus oriP in U373MG-p220.2 cells. Acta Virol. 2010;54:125-30 pubmed
    ..Using U373MG cells we found that HCMV IE86 protein was bound to Mcm3, but did not inhibit the cellular DNA synthesis. Using U373MG-p220...
  16. Wen P, Chidanguro T, Shi Z, Gu H, Wang N, Wang T, et al. Identification of candidate biomarkers and pathways associated with SCLC by bioinformatics analysis. Mol Med Rep. 2018;18:1538-1550 pubmed publisher
    ..minichromosome maintenance protein (MCM) 2, cell division cycle (CDC) 20, cyclin dependent kinase inhibitor 3, MCM3 and CDC6, the mRNA levels of which are upregulated in Oncomine SCLC datasets with the exception of MCM2...
  17. Zhang J, Zhao Y, Chait B, Lathem W, Ritzi M, Knippers R, et al. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. 1998;17:6963-71 pubmed
    ..These results strongly suggest that MCM5 is recruited through interaction with Stat1alpha in a Ser727- and Leu724-dependent manner to play a role in optimal transcriptional activation. ..
  18. Leturcq M, Mortuaire M, Hardiville S, Schulz C, Lefebvre T, Vercoutter Edouart A. O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions. Cell Mol Life Sci. 2018;75:4321-4339 pubmed publisher
    ..We previously reported the O-GlcNAcylation of the minichromosome maintenance proteins MCM2, MCM3, MCM6 and MCM7...
  19. Tempera I, Deng Z, Atanasiu C, Chen C, D Erme M, Lieberman P. Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1. J Virol. 2010;84:4988-97 pubmed publisher
    ..Pharmacological inhibitors of PARP1 enhance OriP plasmid maintenance and increase EBNA1, ORC2, and MCM3 occupancy at OriP...
  20. Zhong H, Chen B, Neves H, Xing J, Ye Y, Lin Y, et al. Expression of minichromosome maintenance genes in renal cell carcinoma. Cancer Manag Res. 2017;9:637-647 pubmed publisher
    ..Expression levels of MCM2, MCM5, MCM6, and MCM7, but not of MCM3 and MCM4, were higher in RCC compared to paired adjacent normal tissue...
  21. Mancheno Valencia A, Bologna Molina R, Toussaint Caire S, Vega Memije M, Cuevas González J. Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. Indian J Pathol Microbiol. 2018;61:225-227 pubmed publisher
    ..Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained ..
  22. Strahan R, Dabral P, Dingman K, Stadler C, Hiura K, Verma S. Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59. J Virol. 2018;92: pubmed publisher
    ..with MCMs were confirmed in both endogenous and overexpression systems, which showed its association with MCM3, MCM4, MCM5, and MCM6...
  23. Kula A, Gharu L, Marcello A. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Virology. 2013;435:329-40 pubmed publisher
    ..We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein. ..
  24. Nie Y, Lang T. The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells. Pharmazie. 2017;72:670-673 pubmed publisher
    ..Differently tagged ATRIP (Myc-, hemaglutinin (HA) or Flag) and minichromosome maintenance (MCM) complex (MCM2, MCM3, MCM5, and MCM6) were transfected into 293T cells...
  25. Liao X, Han C, Wang X, Huang K, Yu T, Yang C, et al. Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy. Cancer Manag Res. 2018;10:3255-3271 pubmed publisher
    ..Through mining public databases, we observed that MCM genes (MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7) were upregulated in pancreatic cancer tumor tissue and ..
  26. Karmakar S, Mahajan M, Schulz V, Boyapaty G, Weissman S. A multiprotein complex necessary for both transcription and DNA replication at the ?-globin locus. EMBO J. 2010;29:3260-71 pubmed publisher
    ..These results imply a direct link between mammalian DNA replication, transcription and histone acetylation mediated by a single multiprotein complex. ..
  27. Zhang C, Elkahloun A, Liao H, Delaney S, Saber B, Morrow B, et al. Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. Mol Cancer Ther. 2011;10:1137-48 pubmed publisher PIAs and LY (TRIB1, KLF2, RHOB, and CDKN1A), and those commonly suppressed by PIAs and LY (IGFBP3, PCNA, PRIM1, MCM3, and HSPA1B)...
  28. Shinya M, Machiki D, Henrich T, Kubota Y, Takisawa H, Mimura S. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Cell Cycle. 2014;13:3271-81 pubmed publisher
    ..Here we report that Xenopus and zebrafish have 2 copies of MCM3 genes, one of which shows a maternal and the other a zygotic expression pattern...
  29. Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed
    ..the identification of phosphorylation sites in the carboxyl terminus of the minichromosome maintenance protein 3 (MCM3), a component of the hexameric MCM DNA helicase...
  30. Ji W, Liu H, Liu C, Shao L, Liu Y, Fan S, et al. Up-regulation of MCM3 Relates to Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats. Cell Mol Neurobiol. 2017;37:683-693 pubmed publisher
    ..Minichromosome maintenance complex component 3 (MCM3) was mainly implied in cell proliferation and tumorigenesis...
  31. Schaarschmidt D, Ladenburger E, Keller C, Knippers R. Human Mcm proteins at a replication origin during the G1 to S phase transition. Nucleic Acids Res. 2002;30:4176-85 pubmed
    ..Thus, human Mcm proteins first assemble at or adjacent to bound ORC and move to other sites during genome replication. ..
  32. Lim C, Chong S, Jiang Y. Udu deficiency activates DNA damage checkpoint. Mol Biol Cell. 2009;20:4183-93 pubmed publisher
    ..two-hybrid and coimmunoprecipitation data demonstrated that PAH-L repeats and SANT-L domain of Udu interacts with MCM3 and MCM4...
  33. Fujita M, Kiyono T, Hayashi Y, Ishibashi M. In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J Biol Chem. 1997;272:10928-35 pubmed
    ..Nuclease digestion-immunoprecipitation techniques of the type described here should facilitate further elucidation of the mode of interaction between hMCMs and chromatin. ..
  34. Lan W, Chen S, Tong L. MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease. Cell Cycle. 2015;14:1973-84 pubmed publisher
    ..A few cell cycle related transcripts were downregulated (2.2-4.5-fold) on addition of miR-215: Mcm3, Dicer1, Cdc25A, Ick, Trip13 and Mcm10...
  35. Li L, Feng Y, Luo R. Minichromosome Maintenance Complex is Required for Checkpoint Kinase 2 Chromatin Loading and its Phosphorylation to DNA Damage Response in SCC-4 Cells. Protein Pept Lett. 2017;24:223-228 pubmed publisher
    ..Differently tagged Chk2 and minichromosome maintenance (MCM) complex (MCM2, MCM3, MCM5, and MCM6) were overexpressed into SCC-4 cells...
  36. Tamberg N, Tahk S, Koit S, Kristjuhan K, Kasvandik S, Kristjuhan A, et al. Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa. Sci Rep. 2018;8:12136 pubmed publisher
    ..of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Our analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target ..
  37. Qi D, Wu B, Tong D, Pan Y, Chen W. Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data. Mol Med Rep. 2015;12:2570-6 pubmed publisher
    ..7 TFs, including S-phase kinase-associated protein 2 (Skp2); minichromosome maintenance complex component 3 (Mcm3); cell division cycle 6 (Cdc6); cyclin B1 (Ccnb1); mutS homolog 6 (Msh6); cyclin A2 (Ccna2); and cyclin B2 (Ccnb2), ..
  38. Vidal M, Lourenço S, Soares F, Gurgel C, Studart E, Valverde L, et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumour Biol. 2016;37:9587-601 pubmed publisher
    ..Using immunohistochemistry, SHH, GLI1, SUFU, HHIP, and STAT3 were investigated. For comparative purposes, MCM3 (cellular proliferation marker) was also included...
  39. Lopes V, Jesus A, Souza L, Miyahara L, Guimarães D, Pontes H, et al. Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study. Braz Oral Res. 2017;31:e66 pubmed publisher
    The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features...
  40. de Albuquerque C, Liang J, Gaut N, Zhou H. Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements. J Biol Chem. 2016;291:8825-35 pubmed publisher
    ..the E3 ligase Mms21, which has a major role in genome maintenance, preferentially controls the sumoylation of Mcm3 during DNA replication...
  41. Fan Y, Liu R, Ding X, Shangguan X, Wu X. [Deguelin inhibits proliferation and regulates the expression of MCM3-CDC45 in MCF-7 and H1299 cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1545-1550 pubmed
    ..cancer MCF-7 cells and lung cancer H1299 cells in vitro and the expression of minichromosome maintenance protein 3 (MCM3) and CDC45 in the cells...
  42. Nguyen T, Jagannathan M, Shire K, Frappier L. Interactions of the human MCM-BP protein with MCM complex components and Dbf4. PLoS ONE. 2012;7:e35931 pubmed publisher
    ..Since DDK is known to activate DNA replication through phosphorylation of these MCM proteins, our results suggest that MCM-BP may affect DNA replication in part by regulating MCM phosphorylation by DDK. ..
  43. Stewart P, Khamis Z, Zhau H, Duan P, Li Q, Chung L, et al. Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer. Oncotarget. 2017;8:39209-39217 pubmed publisher
    ..Importantly, the expression of mini-chromosome maintenance 3 (MCM3) protein, a crucial subunit of DNA helicase, was significantly higher in ARCaPM cells than that of ARCaPE cells...
  44. Panneerselvam J, Pickering A, Han B, Li L, Zheng J, Zhang J, et al. Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate. Oncotarget. 2014;5:1326-37 pubmed
    ..monoubiquitinated FANCD2 can interact with replication origins as well as mini-chromosome maintenance protein 3 (MCM3) in an S-phase specific manner to secure an enough number of the licensed-origins to fire...
  45. Hua C, Zhao G, Li Y, Bie L. Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas. BMC Cancer. 2014;14:526 pubmed publisher
    ..b>MCM3 expression was found to be up-regulated in glioma and correlated with overall survival in patients with WHO grade ..
  46. Gladden A, Diehl J. The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. J Biol Chem. 2003;278:9754-60 pubmed
    ..We now demonstrate that the cyclin D1/CDK4 kinase binds to components of the MCM complex. MCM7 and MCM3 were identified as cyclin D1-binding proteins...
  47. Saade E, Mechold U, Kulyyassov A, Vertut D, Lipinski M, Ogryzko V. Analysis of interaction partners of H4 histone by a new proteomics approach. Proteomics. 2009;9:4934-43 pubmed publisher
    ..Finally, we show that HAT1 requires N-terminal tail of H4 for its stable association with this histone. ..
  48. Blumröder R, Glunz A, Dunkelberger B, Serway C, Berger C, Mentzel B, et al. Mcm3 replicative helicase mutation impairs neuroblast proliferation and memory in Drosophila. Genes Brain Behav. 2016;15:647-59 pubmed publisher
    ..acid substitution in an evolutionarily conserved protein interaction domain of the Minichromosome maintenance 3 (Mcm3) protein...
  49. Cieplinski K, Jozwik M, Semczuk Sikora A, Gogacz M, Lewkowicz D, Ignatov A, et al. Expression of p53 and selected proliferative markers (Ki-67, MCM3, PCNA, and topoisomerase II?) in borderline ovarian tumors: Correlation with clinicopathological features. Histol Histopathol. 2018;33:171-179 pubmed publisher
    ..was to assess the staining pattern and immunolocalization of p53 and selected proliferative markers (Ki-67, MCM3, PCNA, and topoisomerase II?) in borderline ovarian tumors (BOTs)...
  50. Li Y, Gao Y, Qi X, Liu J, Ding L, Yang C, et al. Analysis of factors that affect the precision of the radiographic lateral femoral bowing angle using a three-dimensional computed tomography-based modelling technique. J Orthop Surg Res. 2017;12:92 pubmed publisher
    ..We aimed to investigate factors that affect the precision of the radiographic lateral femoral bowing (RLFB) angle using three-dimensional (3D) models and whether the angle affects surgery design...
  51. Yankulov K, Todorov I, Romanowski P, Licatalosi D, Cilli K, McCracken S, et al. MCM proteins are associated with RNA polymerase II holoenzyme. Mol Cell Biol. 1999;19:6154-63 pubmed
    ..Pol II and GTFs also copurified with MCMs isolated by anti-MCM3 immunoaffinity chromatography...
  52. Takei Y, Assenberg M, Tsujimoto G, Laskey R. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. J Biol Chem. 2002;277:43121-5 pubmed
    ..b>MCM3 acetylating protein, MCM3AP, binds and acetylates MCM3 and inhibits cell cycle progression...
  53. Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Décaillet C, et al. FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Mol Cell. 2013;51:678-90 pubmed publisher
    ..These data reveal that FANCD2 is an effector of ATR signaling implicated in a general replisome surveillance mechanism that is necessary for sustaining cell proliferation and attenuating carcinogenesis. ..
  54. Nowińska K, Chmielewska M, Piotrowska A, Pula B, Pastuszewski W, Krecicki T, et al. Correlation between levels of expression of minichromosome maintenance proteins, Ki-67 proliferation antigen and metallothionein I/II in laryngeal squamous cell cancer. Int J Oncol. 2016;48:635-45 pubmed publisher
    MCM2, MCM3 and MCM7 are minichromosome maintenance proteins found in dividing cells and they play a role in DNA synthesis. Increased MCM expression level is observed in cells of different cancer types...
  55. Wang Q, Li Q, Liu R, Zheng M, Wen J, Zhao G. Host cell interactome of PA protein of H5N1 influenza A virus in chicken cells. J Proteomics. 2016;136:48-54 pubmed publisher
    ..strong enrichment of PA interacting proteins in the category of DNA replication, covering genes such as PCNA, MCM2, MCM3, MCM4, MCM5 and MCM7...
  56. Coşarcă A, Mocan S, Pacurar M, Fülöp E, Ormenişan A. The evaluation of Ki67, p53, MCM3 and PCNA immunoexpressions at the level of the dental follicle of impacted teeth, dentigerous cysts and keratocystic odontogenic tumors. Rom J Morphol Embryol. 2016;57:407-12 pubmed
    The aim of this study is to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers ..
  57. Schimmack S, Lawrence B, Kenney B, Schmitz Winnenthal H, Modlin I, Kidd M. Minichromosome Maintenance Expression Defines Slow-Growing Gastroenteropancreatic Neuroendocrine Neoplasms. Transl Oncol. 2016;9:411-418 pubmed publisher
    ..staining (IHC), Western blot analysis, quantitative polymerase chain reaction, and copy number variations of MCM2, MCM3, and Ki67 were undertaken in SI-NENs (n = 22)...
  58. Starborg M, Brundell E, Gell K, Larsson C, White I, Daneholt B, et al. A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication. J Cell Sci. 1995;108 ( Pt 3):927-34 pubmed
    We have analyzed the expression of the murine P1 gene, the mammalian homologue of the yeast MCM3 protein, during the mitotic cell cycle...
  59. Hast B, Cloer E, Goldfarb D, Li H, Siesser P, Yan F, et al. Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res. 2014;74:808-17 pubmed publisher
    ..These data strengthen the genetic interactions between KEAP1 and NRF2 in cancer and provide new insight into KEAP1 mechanics. ..
  60. Lidstone D, Van Werkhoven H, Needle A, Rice P, McBride J. Gastrocnemius fascicle and achilles tendon length at the end of the eccentric phase in a single and multiple countermovement hop. J Electromyogr Kinesiol. 2018;38:175-181 pubmed publisher
    ..eccentric phase during a hop utilizing a single countermovement (sCM) versus multiple countermovement (mCM1, mCM2, mCM3) strategy. Seventeen healthy males performed nine hopping trials of sCM and nine trials of mCM...
  61. DaFonseca C, Shu F, Zhang J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc Natl Acad Sci U S A. 2001;98:3034-9 pubmed
    ..showed previously that Stat1 recruits a group of nuclear proteins, among them MCM5 (minichromosome maintenance) and MCM3, for transcription activation...
  62. Guan B, Wang X, Yang J, Zhou C, Meng Y. Minichromosome maintenance complex component 7 has an important role in the invasion of papillary urothelial neoplasia. Oncol Lett. 2015;10:946-950 pubmed
    ..The MCM7, MCM3 and Ki67 proteins were detected in 154 cases of urothelial neoplasia using immunohistochemical analysis...
  63. Schermerhorn K, Tanner N, Kelman Z, Gardner A. High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases. Nucleic Acids Res. 2016;44:8764-8771 pubmed
    ..9°N (9°N). Mth encodes a single MCM homolog while 9°N encodes three helicases. 9°N MCM3, the proposed replicative helicase, unwinds DNA at a faster rate compared to 9°N MCM2 and to Mth MCM...
  64. Musahl C, Schulte D, Burkhart R, Knippers R. A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. Eur J Biochem. 1995;230:1096-101 pubmed
    ..Protein hCdc21 forms a stable trimeric complex with two novel human Mcm proteins, p85Mcm and p105Mcm. Protein BM28/Mcm2 is more loosely associated with the trimeric hCdc21 complex. ..
  65. Tsvetkov L, Stern D. Interaction of chromatin-associated Plk1 and Mcm7. J Biol Chem. 2005;280:11943-7 pubmed
    ..The strongest interaction between endogenous Plk1 and Mcm7 was detected in a soluble chromatin fraction. These findings suggest a new function for Plk1 in coordination of DNA replication and mitotic events. ..
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    ..roles of specific MCM phosphorylation events are poorly characterized, we now demonstrate that CDK1 phosphorylates MCM3 at Ser-112, Ser-611, and Thr-719...
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