MCM10

Summary

Gene Symbol: MCM10
Description: minichromosome maintenance 10 replication initiation factor
Alias: CNA43, DNA43, PRO2249, protein MCM10 homolog, MCM10 minichromosome maintenance deficient 10, homolog of yeast MCM10, hsMCM10, minichromosome maintenance complex component 10
Species: human
Products:     MCM10

Top Publications

  1. Izumi M, Yatagai F, Hanaoka F. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. J Biol Chem. 2001;276:48526-31 pubmed
    b>Mcm10 (Dna43) is an essential protein for chromosomal DNA replication in Saccharomyces cerevisiae. Recently, we identified a human Mcm10 homolog that interacts with the mammalian Orc2 and Mcm2-7 complex...
  2. Wohlschlegel J, Dhar S, Prokhorova T, Dutta A, Walter J. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell. 2002;9:233-40 pubmed
    Current models suggest that the replication initiation factor Mcm10 is required for association of Mcm2-7 with origins of replication to generate the prereplicative complex (pre-RC)...
  3. Sharma A, Kaur M, Kar A, Ranade S, Saxena S. Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10. J Biol Chem. 2010;285:8352-62 pubmed publisher
    We report that upon UV radiation insult, mammalian cells specifically down-regulate Mcm10, a protein essential for the initiation and elongation phases of DNA replication...
  4. Warren E, Huang H, Fanning E, Chazin W, Eichman B. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009;284:24662-72 pubmed publisher
    b>Mcm10 is an essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication...
  5. Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon K, et al. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Nucleic Acids Res. 2000;28:4769-77 pubmed
    ..Human Mcm10 (HsMcm10) is a 98-kDa protein of 874 amino acids which shows 23 and 21% overall similarity to Schizosaccharomyces pombe ..
  6. Bell S, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem. 2002;71:333-74 pubmed
    ..We emphasize recent progress in determining the function of the different replication factors once they have been assembled at the origin. ..
  7. Park J, Bang S, Kim S, Hwang D. Knockdown of human MCM10 activates G2 checkpoint pathway. Biochem Biophys Res Commun. 2008;365:490-5 pubmed
    b>MCM10 has been shown to be a component for the elongation step of chromosome replication in model organisms such as yeast. In the accompanying manuscript [J.H. Park, S.W. Bang, Y. Jeon, S. Kang, D.S...
  8. Park J, Bang S, Jeon Y, Kang S, Hwang D. Knockdown of human MCM10 exhibits delayed and incomplete chromosome replication. Biochem Biophys Res Commun. 2008;365:575-82 pubmed
    In model organisms, MCM10 is required for forming the pre-initiation complex for initiation of chromosome replication and is involved in the elongation step...
  9. Okorokov A, Waugh A, Hodgkinson J, Murthy A, Hong H, Leo E, et al. Hexameric ring structure of human MCM10 DNA replication factor. EMBO Rep. 2007;8:925-30 pubmed
    The DNA replication factor minichromosome maintenance 10 (MCM10) is a conserved, abundant nuclear protein crucial for origin firing...

More Information

Publications73

  1. Zhu W, Ukomadu C, Jha S, Senga T, Dhar S, Wohlschlegel J, et al. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes Dev. 2007;21:2288-99 pubmed
    ..We show that And-1/Ctf4 (Chromosome transmission fidelity 4) interacts with Mcm10, which associates with MCM2-7, and with the p180 subunit of DNA pol alpha...
  2. Izumi M, Yatagai F, Hanaoka F. Localization of human Mcm10 is spatially and temporally regulated during the S phase. J Biol Chem. 2004;279:32569-77 pubmed
    Mcm10 (Dna43) is an essential protein for the initiation of DNA replication in Saccharomyces cerevisiae...
  3. Lu P, Qiao J, He W, Wang J, Jia Y, Sun Y, et al. Genome-wide gene expression profile analyses identify CTTN as a potential prognostic marker in esophageal cancer. PLoS ONE. 2014;9:e88918 pubmed publisher
    ..Several candidate deregulated genes including four overexpressed (CTTN, DMRT2, MCM10 and SCYA26) and two underexpressed (HMGCS2 and SORBS2) were subsequently verified, which can be served as ..
  4. Mayle R, Langston L, Molloy K, Zhang D, Chait B, O Donnell M. Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression. Proc Natl Acad Sci U S A. 2019;116:798-803 pubmed publisher
    The 11-subunit eukaryotic replicative helicase CMG (Cdc45, Mcm2-7, GINS) tightly binds Mcm10, an essential replication protein in all eukaryotes...
  5. Ishimi Y. Regulation of MCM2-7 function. Genes Genet Syst. 2018;93:125-133 pubmed publisher
    ..To activate CMG helicase, the two protein kinases CDK and DDK, as well as MCM10, are required...
  6. Warren E, Vaithiyalingam S, Haworth J, Greer B, Bielinsky A, Chazin W, et al. Structural basis for DNA binding by replication initiator Mcm10. Structure. 2008;16:1892-901 pubmed publisher
    b>Mcm10 is an essential eukaryotic DNA replication protein required for assembly and progression of the replication fork...
  7. Haworth J, Alver R, Anderson M, Bielinsky A. Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication. Mol Biol Cell. 2010;21:3205-19 pubmed publisher
    ..Cdc17, the catalytic subunit of pol-α in yeast, is rapidly degraded after depletion of Mcm10. Here we show that Ubc4 and Not4 are required for Cdc17 destabilization...
  8. Lan W, Chen S, Tong L. MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease. Cell Cycle. 2015;14:1973-84 pubmed publisher
    ..2-4.5-fold) on addition of miR-215: Mcm3, Dicer1, Cdc25A, Ick, Trip13 and Mcm10. Theoretic binding energies were used to predict miR-215 binding targets and luciferase reporter studies confirmed ..
  9. Pulliam K, Fasken M, McLane L, Pulliam J, Corbett A. The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae. Genetics. 2009;181:105-18 pubmed publisher
    ..proteins likely to be affected in these mutants and provide evidence that three of these cargoes, Cdc45, Yox1, and Mcm10, are not efficiently localized to the nucleus in importin-alpha mutants...
  10. Mahadevappa R, Neves H, Yuen S, Jameel M, Bai Y, Yuen H, et al. DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel). 2018;10: pubmed publisher
    ..Here, we studied the role of MCM10, a novel licensing factor, in breast cancer progression...
  11. Yeates L, Ingles J, Gray B, Singarayar S, Sy R, Semsarian C, et al. A balanced translocation disrupting SCN5A in a family with Brugada syndrome and sudden cardiac death. Heart Rhythm. 2019;16:231-238 pubmed publisher
    ..a balanced translocation breaking the SCN5A gene on chromosome 3 and the multiple chromosome maintenance 10 gene (MCM10) on chromosome 10 t(3;10)(p22.2;p13)...
  12. Sang L, Wang X, Xu D, Zhao W. Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma. World J Gastroenterol. 2018;24:2605-2616 pubmed publisher
    ..as hub genes for Hyper-LGs, and CDC45, DTL, AURKB, CDKN3, MCM2, and MCM10 were hub genes for Hypo-HGs by combining six ranked methods of cytoHubba...
  13. Douglas M, Ali F, Costa A, Diffley J. The mechanism of eukaryotic CMG helicase activation. Nature. 2018;555:265-268 pubmed publisher
    ..b>Mcm10, together with ATP hydrolysis, then triggers further DNA untwisting and helicase activation...
  14. Kohzaki H. The function of replication and SCF complex during Drosophila wing development. Front Biosci (Landmark Ed). 2018;23:2235-2244 pubmed
    ..paper, I investigated in detail the wing phenotype using RNAi flies, and observed that the knockdown not only of Mcm10 but also of some other prereplicative complex components including Cdt1, Polα-primase, RPA, Psf2 (partner of SLD ..
  15. Liu Z, Li J, Chen J, Shan Q, Dai H, Xie H, et al. MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression. BMC Cancer. 2018;18:200 pubmed publisher
    ..MCM2-7, MCM8 and MCM10 was significantly up-regulated in HCC in Cohort 1...
  16. Reubens M, Biller M, Bedsole S, Hopkins L, Ables E, Christensen T. Mcm10 is required for oogenesis and early embryogenesis in Drosophila. Mech Dev. 2015;138 Pt 3:291-9 pubmed publisher
    ..It is well documented that Mcm10 is intimately linked to both of these important biological processes; therefore, it is not surprising that Mcm10 ..
  17. Pérez Arnaiz P, Bruck I, Kaplan D. Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res. 2016;44:315-29 pubmed publisher
    b>Mcm10 is an essential replication factor that is required for DNA replication in eukaryotes. Two key steps in the initiation of DNA replication are the assembly and activation of Cdc45-Mcm2-7-GINS (CMG) replicative helicase...
  18. Senfter D, Erkan E, Ozer E, Jungwirth G, Madlener S, Kool M, et al. Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..Our data showed that most of the pre-RC components are significantly overexpressed in MB. Among all pre-RC mRNAs, MCM10 showed the highest level of expression (?500- to 1,000-fold) in MB cell lines and tissues compared to the levels ..
  19. Pérez Arnaiz P, Kaplan D. An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation. J Mol Biol. 2016;428:4608-4625 pubmed publisher
    b>Mcm10 is an essential protein that functions to initiate DNA replication after the formation of the replication fork helicase...
  20. Kim J, Kim Y, Choi H, Kwon A, Jekarl D, Lee S, et al. Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells. Cell Death Dis. 2018;9:139 pubmed publisher
    ..decreased during passaging along with the reduction in series of molecules including hub genes; CDK1, CCNA2, MCM10, E2F1, BRCA1, HIST1H1A and HIST1H3B...
  21. Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky A, Eichman B. Mcm10 self-association is mediated by an N-terminal coiled-coil domain. PLoS ONE. 2013;8:e70518 pubmed publisher
    Minichromosome maintenance protein 10 (Mcm10) is an essential eukaryotic DNA-binding replication factor thought to serve as a scaffold to coordinate enzymatic activities within the replisome...
  22. Wang A, Zhang Y, Tumbar T. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 2017;36:61-78 pubmed publisher
    ..keratinocytes, Edaradd rescues DNA damage, cell survival, and proliferation of Gata6 knockout cells and restores MCM10 expression...
  23. Bruck I, Dhingra N, Kaplan D. A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase. J Biol Chem. 2017;292:3062-3073 pubmed publisher
    ..kinases that phosphorylate replication proteins during S phase, and Dpb11, Sld2, Sld3, Pol ϵ, and Mcm10 are factors that are also required for replication initiation...
  24. Moskot M, Jakóbkiewicz Banecka J, Smolińska E, Piotrowska E, Węgrzyn G, Gabig Cimińska M. Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts. Mol Cell Biochem. 2015;407:97-109 pubmed publisher
    ..It considerably reduced the efficiency of expression of genes coding for MCM2-7 and MCM10 helicases, as well as some other proteins involved in the S phase control...
  25. Chadha G, Gambus A, Gillespie P, Blow J. Xenopus Mcm10 is a CDK-substrate required for replication fork stability. Cell Cycle. 2016;15:2183-2195 pubmed
    ..b>Mcm10 is one of several proteins that have been implicated from work in yeasts to play a role in forming a mature ..
  26. Thu Y, Van Riper S, Higgins L, Zhang T, Becker J, Markowski T, et al. Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression. Cell Rep. 2016;15:1254-65 pubmed publisher
    Loss of minichromosome maintenance protein 10 (Mcm10) causes replication stress. We uncovered that S. cerevisiae mcm10-1 mutants rely on the E3 SUMO ligase Mms21 and the SUMO-targeted ubiquitin ligase complex Slx5/8 for survival...
  27. Vo N, Anh Suong D, Yoshino N, Yoshida H, Cotterill S, Yamaguchi M. Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation. Nucleic Acids Res. 2017;45:1233-1254 pubmed publisher
    Both Mcm10 and HP1a are known to be required for DNA replication. However, underlying mechanism is not clarified yet especially for HP1...
  28. Kliszczak M, Sedlackova H, Pitchai G, Streicher W, Krejci L, Hickson I. Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget. 2015;6:40464-79 pubmed publisher
    ..In budding yeast, two essential replication factors, Sld2 and Mcm10, are then important for the activation of replication origins...
  29. Alver R, Zhang T, Josephrajan A, Fultz B, Hendrix C, Das Bradoo S, et al. The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage. Nucleic Acids Res. 2014;42:8389-404 pubmed publisher
    Accurate replication of the genome requires the evolutionarily conserved minichromosome maintenance protein, Mcm10. Although the details of the precise role of Mcm10 in DNA replication are still debated, it interacts with the Mcm2-7 core ..
  30. Lõoke M, Maloney M, Bell S. Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase. Genes Dev. 2017;31:291-305 pubmed publisher
    ..binding of the helicase-activating proteins Cdc45 and GINS (forming the CMG complex), an additional protein, Mcm10, drives initial origin DNA unwinding by an unknown mechanism...
  31. Zhang T, Fultz B, Das Bradoo S, Bielinsky A. Mapping ubiquitination sites of S. cerevisiae Mcm10. Biochem Biophys Rep. 2016;8:212-218 pubmed publisher
    ..As a multivalent DNA scaffold, Mcm10 coordinates the action of proteins that are indispensable for lagging strand synthesis, such as the replication ..
  32. Quan Y, Xia Y, Liu L, Cui J, Li Z, Cao Q, et al. Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell Rep. 2015;13:2576-2586 pubmed publisher
    ..Interestingly, Mcm10, a robust MCM interactor, co-purifies exclusively with the DHs in the context of chromatin...
  33. Wotschofsky Z, Gummlich L, Liep J, Stephan C, Kilic E, Jung K, et al. Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p. PLoS ONE. 2016;11:e0148746 pubmed publisher
    ..Specifically, we showed that CXCL8/IL8, UHRF1, MCM10, and CDKN3 were downregulated and targeted by miR-146a-5p...
  34. Liao Y, Zeng J, Zhou J, Yang G, Ding K, Zhang X. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Mol Med Rep. 2016;13:4872-8 pubmed publisher
    ..inhibited cell proliferation and arrested cell cycle at the G1 phase, via reducing the expression levels of the MCM10, CDK2, CDC24A and CDC6 cell cycle?associated proteins in the T24 and 5637 cells...
  35. Douglas M, Diffley J. Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem. 2016;291:5879-88 pubmed publisher
    b>Mcm10 is required for the initiation of eukaryotic DNA replication and contributes in some unknown way to the activation of the Cdc45-MCM-GINS (CMG) helicase...
  36. Izumi M, Mizuno T, Yanagi K, Sugimura K, Okumura K, Imamoto N, et al. The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. J Biol Chem. 2017;292:13008-13021 pubmed publisher
    The protein mini-chromosome maintenance 10 (Mcm10) was originally identified as an essential yeast protein in the maintenance of mini-chromosome plasmids...
  37. Xu X, Rochette P, Feyissa E, Su T, Liu Y. MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J. 2009;28:3005-14 pubmed publisher
    ..We found that essential replisome factors MCM10, MCM2-7 helicase, CDC45 and GINS are the primary interaction partner proteins of human RECQ4...
  38. Romani B, Shaykh Baygloo N, Aghasadeghi M, Allahbakhshi E. HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest. J Biol Chem. 2015;290:17380-9 pubmed publisher
    ..In this study, we show that HIV-1 Vpr indirectly binds MCM10, a eukaryotic DNA replication factor, in a Vpr-binding protein (VprBP) (VprBP)-dependent manner...
  39. Li W, Huang C, Ke H, Li C, Wei Y, Yeh H, et al. MCM10 overexpression implicates adverse prognosis in urothelial carcinoma. Oncotarget. 2016;7:77777-77792 pubmed publisher
    ..transcriptome of UBUC (GSE31684), we identified Minichromosome Maintenance Complex Component 2 (MCM2) and MCM10 as the two most significantly upregulated genes in UC progression among the MCM gene family, the key factors for ..
  40. Yoshida K, Inoue I. Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. Oncogene. 2004;23:6250-60 pubmed
    b>MCM10 and TopBP1 function in the initiation of DNA replication, by regulating the chromatin binding of the DNA polymerase alpha loading factor, CDC45. TopBP1 is also known as a DNA damage response protein...
  41. Morimoto S. [Abnormal myocardial contractile regulation mechanism in familial hypertrophic and dilated cardiomyopathies--functional analysis of molecular mutant troponin in in-vitro]. Fukuoka Igaku Zasshi. 2002;93:1-5 pubmed
  42. Pérez Arnaiz P, Bruck I, Colbert M, Kaplan D. An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-? to Mcm2-7. Nucleic Acids Res. 2017;45:7261-7275 pubmed publisher
    b>Mcm10 is an essential eukaryotic factor required for DNA replication. The replication fork helicase is composed of Cdc45, Mcm2-7 and GINS (CMG)...
  43. Christensen T, Tye B. Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol Biol Cell. 2003;14:2206-15 pubmed
    b>Mcm10 is required for the initiation of DNA replication in Saccharomyces cerevisiae. We have cloned MCM10 from Drosophila melanogaster and show that it complements a ScMCM10 null mutant...
  44. Di Perna R, Aria V, De Falco M, Sannino V, Okorokov A, Pisani F, et al. The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties. Biochem J. 2013;454:333-43 pubmed publisher
    The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is required for assembly and function of the replication fork protein machinery...
  45. Du W, Stauffer M, Eichman B. Structural biology of replication initiation factor Mcm10. Subcell Biochem. 2012;62:197-216 pubmed publisher
    Minichromosome maintenance protein 10 (Mcm10) is a non-enzymatic replication factor required for proper assembly of the eukaryotic replication fork...
  46. Baxley R, Bielinsky A. Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks. Genes (Basel). 2017;8: pubmed publisher
    ..Minichromosome maintenance protein 10 (Mcm10) is a conserved component of the eukaryotic replisome that contributes to this process in multiple ways...
  47. Sar F, Lindsey Boltz L, Subramanian D, Croteau D, Hutsell S, Griffith J, et al. Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. J Biol Chem. 2004;279:39289-95 pubmed
  48. Im J, Ki S, Farina A, Jung D, Hurwitz J, Lee J. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A. 2009;106:15628-32 pubmed publisher
    ..Stable association of CMG required all three components of the CMG complex as well as RecQL4, Ctf4/And-1, and Mcm10. Surprisingly, depletion of TopBP1, a homologue of Dpb11 that plays an essential role in the chromatin loading of ..
  49. Satoh J, Nanri Y, Yamamura T. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. J Neurosci Methods. 2006;152:278-88 pubmed
    ..These results suggest that protein microarray is a powerful tool for rapid and comprehensive profiling of 14-3-3-binding proteins. ..
  50. Clarke C, Clarke P. DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J. 2005;388:705-12 pubmed
    ..This cell-free system will facilitate further biochemical analysis of the Chk1 pathway in humans. ..
  51. Malhotra A, Igo R, Thameem F, Kao W, Abboud H, Adler S, et al. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. Diabetes Metab Res Rev. 2009;25:740-7 pubmed publisher
    ..The strong evidence for linkage on chromosome 4q in AA provides important information given the paucity of diabetes genetic studies in this population. ..
  52. Lewis J, Spenkelink L, Schauer G, Hill F, Georgescu R, O Donnell M, et al. Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome. Proc Natl Acad Sci U S A. 2017;114:10630-10635 pubmed publisher
    ..The Minichromosome maintenance protein 10 (Mcm10), an important player in CMG activation, increases the number of productive replication events in our assay...
  53. Fatoba S, Tognetti S, Berto M, Leo E, Mulvey C, Godovac Zimmermann J, et al. Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Nucleic Acids Res. 2013;41:4065-79 pubmed publisher
    The eukaryotic DNA replication initiation factor Mcm10 is essential for both replisome assembly and function...
  54. Kaur M, Khan M, Kar A, Sharma A, Saxena S. CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10. Nucleic Acids Res. 2012;40:7332-46 pubmed publisher
    ..UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication...
  55. Cook C, Kung G, Peterson F, Volkman B, Lei M. A novel zinc finger is required for Mcm10 homocomplex assembly. J Biol Chem. 2003;278:36051-8 pubmed
    b>Mcm10 is a DNA replication factor that interacts with multiple subunits of the MCM2-7 hexameric complex. We report here that Mcm10 self-interacts and assembles into large homocomplexes (approximately 800 kDa)...
  56. Roesch F, Richard L, Rua R, Porrot F, Casartelli N, Schwartz O. Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells. J Virol. 2015;89:12118-30 pubmed publisher
    ..This report provides novel insights into how Vpr manipulates TNF production and helps clarify the role of Vpr in innate immune responses and inflammation. ..
  57. Zhang W, Yeung C, Wu L, Yuen K. E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae. elife. 2017;6: pubmed publisher
    ..for the loading of cohesin complex to chromatin in G1, but regulates the localization of replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins in G1 and S phases, and ..
  58. Kohzaki H, Asano M, Murakami Y. DNA replication machinery is required for development in Drosophila. Front Biosci (Landmark Ed). 2018;23:493-505 pubmed
    ..Interestingly, wing specific knockdown of Mcm10 induced wing formation defects...
  59. Langston L, Mayle R, Schauer G, Yurieva O, Zhang D, Yao N, et al. Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. elife. 2017;6: pubmed publisher
    ..This report demonstrates that Mcm10, an essential replication protein unique to eukaryotes, binds CMG and greatly stimulates its helicase activity in ..
  60. Miyazawa Onami M, Araki H, Tanaka S. Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer. EMBO Rep. 2017;18:1752-1761 pubmed publisher
    ..during firing in the budding yeast Saccharomyces cerevisiae Pre-IC assembly is observed in the absence of Mcm10, one of the firing factors, and is mutually dependent on all the firing factors whose association to replication ..
  61. Thu Y, Bielinsky A. MCM10: one tool for all-Integrity, maintenance and damage control. Semin Cell Dev Biol. 2014;30:121-30 pubmed publisher
    Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function...
  62. Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman Smook H, Pugh D, et al. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep. 2014;7:575-587 pubmed publisher
    ..This repressor negatively regulates transcription and levels of the MCM10 replication factor on chromatin...
  63. Im J, Park S, Cho W, Bae S, Hurwitz J, Lee J. RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells. Cell Cycle. 2015;14:1001-9 pubmed publisher
    ..Here, we show that RecQL4 is required for the origin binding of Mcm10 and Ctf4, and their physical interactions and association with replication origins are controlled by the concerted ..
  64. Chattopadhyay S, Bielinsky A. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. Mol Biol Cell. 2007;18:4085-95 pubmed
    ..and functions as a nuclear chaperone for the catalytic subunit, which is rapidly degraded in the absence of Mcm10. We report here that the interaction between Mcm10 and pol-alpha is conserved in human cells...