MCAM

Summary

Gene Symbol: MCAM
Description: melanoma cell adhesion molecule
Alias: CD146, MUC18, cell surface glycoprotein MUC18, Gicerin, S-endo 1 endothelial-associated antigen, cell surface glycoprotein P1H12, melanoma adhesion molecule, melanoma-associated antigen A32, melanoma-associated antigen MUC18
Species: human
Products:     MCAM

Top Publications

  1. Stopp S, Bornhauser M, Ugarte F, Wobus M, Kuhn M, Brenner S, et al. Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells. Haematologica. 2013;98:505-13 pubmed publisher
  2. Zeng G, Cai S, Liu Y, Wu G. METCAM/MUC18 augments migration, invasion, and tumorigenicity of human breast cancer SK-BR-3 cells. Gene. 2012;492:229-38 pubmed publisher
    Previous research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as a promoter or a suppressor in the development of human breast cancer by MCF7, MDA-MB-231, and MDA-MB-..
  3. Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, et al. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012;120:2330-9 pubmed publisher
    b>CD146 is a novel endothelial biomarker and plays an essential role in angiogenesis; however, its role in the molecular mechanism underlying angiogenesis remains poorly understood...
  4. Bardin N, Frances V, Lesaule G, Horschowski N, George F, Sampol J. Identification of the S-Endo 1 endothelial-associated antigen. Biochem Biophys Res Commun. 1996;218:210-6 pubmed
    ..this protein around 118 kDa and located at the endothelial cell-cell junction presented sequence identity with MUC18 described as a tumor marker in human melanoma...
  5. Fritzsche F, Wassermann K, Rabien A, Schicktanz H, Dankof A, Loening S, et al. CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 2008;40:457-64 pubmed publisher
    b>CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours...
  6. Shih I. The role of CD146 (Mel-CAM) in biology and pathology. J Pathol. 1999;189:4-11 pubmed
    CD146, also known as Mel-CAM, MUC18, A32 antigen, and S-Endo-1, is a membrane glycoprotein which functions as a Ca(2+)-independent cell adhesion molecule involved in heterophilic cell-cell interactions...
  7. Wang Z, Yan X. CD146, a multi-functional molecule beyond adhesion. Cancer Lett. 2013;330:150-62 pubmed publisher
    b>CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular junction of endothelial cells...
  8. Corselli M, Chin C, Parekh C, Sahaghian A, Wang W, Ge S, et al. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013;121:2891-901 pubmed publisher
    ..In order to define their direct role in hematopoiesis, we tested the ability of purified human CD146(+) perivascular cells, as compared with unfractionated MSCs and CD146(-) cells, to sustain human HSPCs in ..
  9. McGary E, Lev D, Bar Eli M. Cellular adhesion pathways and metastatic potential of human melanoma. Cancer Biol Ther. 2002;1:459-65 pubmed
    ..The cellular adhesion molecule MCAM/MUC18 confers metastatic potential and increased tumorigenicity to melanoma cells...

More Information

Publications84

  1. Wang F, Xing T, Wang N, Liu L. Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy. Cytokine. 2012;57:127-9 pubmed publisher
    To investigate the levels of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy at different stages. A total of 80 patients with type 2 diabetes mellitus were enrolled in the present study...
  2. Alais S, Allioli N, Pujades C, Duband J, Vainio O, Imhof B, et al. HEMCAM/CD146 downregulates cell surface expression of beta1 integrins. J Cell Sci. 2001;114:1847-59 pubmed
    HEMCAM/gicerin, an immunoglobulin superfamily protein, is involved in homophilic and heterophilic adhesion. It interacts with NOF (neurite outgrowth factor), a molecule of the laminin family...
  3. Li G, Kalabis J, Xu X, Meier F, Oka M, Bogenrieder T, et al. Reciprocal regulation of MelCAM and AKT in human melanoma. Oncogene. 2003;22:6891-9 pubmed
    ..These data link AKT activation with MelCAM expression, and implicate that intervention of MelCAM-AKT signaling axis in melanoma is a potential therapeutical approach. ..
  4. Kang Y, Wang F, Feng J, Yang D, Yang X, Yan X. Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell Res. 2006;16:313-8 pubmed
    Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear...
  5. Pickl W, Majdic O, Fischer G, Petzelbauer P, Fae I, Waclavicek M, et al. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol. 1997;158:2107-15 pubmed
    ..here that human T cells, upon activation, neo-express the melanoma metastasis-associated surface molecule MUC18/melanoma cell adhesion molecule (MCAM)...
  6. Zheng C, Qiu Y, Zeng Q, Zhang Y, Lu D, Yang D, et al. Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization. Int J Biochem Cell Biol. 2009;41:2163-72 pubmed publisher
    ..b>CD146 is identified as an endothelial cell adhesion molecule and implicated in blood vessel formation, however, its ..
  7. Sers C, Kirsch K, Rothbächer U, Riethmuller G, Johnson J. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A. 1993;90:8514-8 pubmed
    The cell surface glycoprotein MUC18, a member of the immunoglobulin superfamily and homologous to several cell adhesion molecules, is associated with tumor progression and the development of metastasis in human malignant melanoma...
  8. Bardin N, Blot Chabaud M, Despoix N, Kebir A, Harhouri K, Arsanto J, et al. CD146 and its soluble form regulate monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 2009;29:746-53 pubmed publisher
    ..Among molecules at the interendothelial junction, CD146 is involved in cell-cell cohesion and permeability, but its role in monocyte transmigration is unknown...
  9. Zabouo G, Imbert A, Jacquemier J, Finetti P, Moreau T, Esterni B, et al. CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines. Breast Cancer Res. 2009;11:R1 pubmed publisher
    ..b>CD146 (MCAM) is associated with an advanced tumor stage in melanoma, prostate cancer and ovarian cancer...
  10. Oka S, Uramoto H, Chikaishi Y, Tanaka F. The expression of CD146 predicts a poor overall survival in patients with adenocarcinoma of the lung. Anticancer Res. 2012;32:861-4 pubmed
    ..The expression of mesenchymal marker genes might be associated with a more aggressive form of the disease. CD146 is a marker of mesenchymal cells, a potentially metastasis-promoting cell adhesion molecule, and its expression ..
  11. Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol. 2007;179:6673-85 pubmed
    The melanoma cell adhesion molecule (MCAM)/CD146 is expressed as two isoforms differing by their cytoplasmic domain (MCAM long (MCAM-l) and MCAM short (MCAM-s))...
  12. Stalin J, Harhouri K, Hubert L, Subrini C, Lafitte D, Lissitzky J, et al. Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin. J Biol Chem. 2013;288:8991-9000 pubmed publisher
    The melanoma cell adhesion molecule (CD146) contains a circulating proteolytic variant (sCD146), which is involved in inflammation and angiogenesis...
  13. Bardin N, Moal V, Anfosso F, Daniel L, Brunet P, Sampol J, et al. Soluble CD146, a novel endothelial marker, is increased in physiopathological settings linked to endothelial junctional alteration. Thromb Haemost. 2003;90:915-20 pubmed
    b>CD146, a novel cell adhesion molecule localized at the endothelial junction, is involved in the control of cell-cell cohesion. It is found as a soluble form in conditioned medium of cultured endothelial cells...
  14. Anfosso F, Bardin N, Vivier E, Sabatier F, Sampol J, Dignat George F. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. J Biol Chem. 2001;276:1564-9 pubmed
    CD146 (S-Endo 1 Ag or MUC18) is a transmembrane glycoprotein expressed on endothelial cells on the whole vascular tree. CD146 is located at the intercellular junction where it plays a role in the cohesion of the endothelial monolayer...
  15. Ye Z, Zhang C, Tu T, Sun M, Liu D, Lu D, et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun. 2013;4:2803 pubmed publisher
    ..Here we report that Wnt5a uses CD146 as a receptor to regulate cell migration and zebrafish embryonic convergent extension...
  16. Watson Hurst K, Becker D. The role of N-cadherin, MCAM and beta3 integrin in melanoma progression, proliferation, migration and invasion. Cancer Biol Ther. 2006;5:1375-82 pubmed
    ..The cell adhesion molecules N-cadherin, MCAM and beta3 integrin have been suggested to represent melanoma progression markers; yet, little is known as to ..
  17. Aldovini D, Demichelis F, Doglioni C, Di Vizio D, Galligioni E, Brugnara S, et al. M-CAM expression as marker of poor prognosis in epithelial ovarian cancer. Int J Cancer. 2006;119:1920-6 pubmed
    ..In particular, M-CAM expression identifies a subgroup of front-line therapy-responding patients who undergo dramatic relapses, thus helping to better select patients who might benefit from new/alternative therapeutic modalities. ..
  18. Liu W, Ji S, Sun J, Zhang Y, Liu Z, Liang A, et al. CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer. Int J Mol Sci. 2012;13:6399-406 pubmed publisher
    b>CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance...
  19. Wu G, Wu M, Wang C, Liu Y. Enforced expression of METCAM/MUC18 increases tumorigenesis of human prostate cancer LNCaP cells in nude mice. J Urol. 2011;185:1504-12 pubmed publisher
    Metastasis cell adhesion molecule/MUC18, a cell adhesion molecule in the Ig-like gene super family, is a key determinant in prostate cancer cell progression...
  20. Zeng G, Cai S, Wu G. Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells. BMC Cancer. 2011;11:113 pubmed publisher
    Conflicting research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as both a tumor promoter and a tumor suppressor in the development of breast cancer...
  21. Luo Y, Zheng C, Zhang J, Lu D, Zhuang J, Xing S, et al. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene. 2012;31:306-21 pubmed publisher
    ..Previous data indicated that CD146 expression correlates with malignant progression and metastatic potential of human melanoma cells...
  22. Lehmann J, Riethmuller G, Johnson J. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci U S A. 1989;86:9891-5 pubmed
    The MUC18 antigen is an integral membrane glycoprotein of 113 kDa whose expression on primary human melanomas correlates with poor prognosis and the development of metastatic disease...
  23. Saito T, Saito O, Kawano T, Tamemoto H, Kusano E, Kawakami M, et al. Elevation of serum adiponectin and CD146 levels in diabetic nephropathy. Diabetes Res Clin Pract. 2007;78:85-92 pubmed
    The present study was undertaken to measure serum levels of adiponectin and CD146, an endothelial cell injury marker, and to clarify the property of adiponectin and CD146 in patients with diabetic nephropathy...
  24. Melnikova V, Balasubramanian K, Villares G, Dobroff A, Zigler M, Wang H, et al. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009;284:28845-55 pubmed publisher
    ..mechanism whereby protease-activated receptor 1 (PAR1) mediates expression of melanoma cell adhesion molecule MCAM/MUC18 (MUC18), a critical marker of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) ..
  25. Russell K, Phinney D, Lacey M, Barrilleaux B, Meyertholen K, O Connor K. In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells. 2010;28:788-98 pubmed publisher
    ..b>CD146 may be a marker of multipotency, with approximately 2-fold difference in mean fluorescence intensity between tri- ..
  26. Tormin A, Li O, Brune J, Walsh S, Schütz B, Ehinger M, et al. CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization. Blood. 2011;117:5067-77 pubmed publisher
    ..colony-forming units-fibroblast (CFU-Fs) were highly and exclusively enriched not only in the lin?/CD271?/CD45?/CD146? stem-cell fraction, but also in lin?/CD271?/CD45?/CD146(?/low) cells...
  27. Larochelle C, Cayrol R, Kebir H, Alvarez J, Lécuyer M, Ifergan I, et al. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain. 2012;135:2906-24 pubmed publisher
    ..Using proteomic techniques, we identified expression of melanoma cell adhesion molecule (MCAM) on a subset of human effector memory CD4(+) lymphocytes and on human blood-brain barrier endothelium...
  28. Wu G, Wu M, Wang S, Liu Z, Qu P, Peng Q, et al. Isolation and characterization of the major form of human MUC18 cDNA gene and correlation of MUC18 over-expression in prostate cancer cell lines and tissues with malignant progression. Gene. 2001;279:17-31 pubmed
    ..To determine if MUC18 expression correlates with the development and malignant progression of prostate cancer, we investigated ..
  29. Bardin N, Frances V, Combes V, Sampol J, Dignat George F. CD146: biosynthesis and production of a soluble form in human cultured endothelial cells. FEBS Lett. 1998;421:12-4 pubmed
    We previously identified the S-Endo 1-associated antigen (CD146), an endothelial member of the immunoglobulin superfamily with a characteristic V-V-C2-C2-C2 Ig domain structure...
  30. Li X, Deeg H. Murine xenogeneic models of myelodysplastic syndrome: an essential role for stroma cells. Exp Hematol. 2014;42:4-10 pubmed publisher
    ..Expression of CD146 on stroma cells conveys an engraftment-facilitating effect...
  31. Liu X, Genet M, Haines J, Mehanna E, Wu S, Chen H, et al. ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Mol Cancer Res. 2015;13:1206-17 pubmed publisher
    ..Functional assessment of ZBTB7A-regulated genes identified MCAM, which encodes an adhesion protein key to melanoma metastasis...
  32. Fawzy El Sayed K, Klingebiel P, Dörfer C. Toll-like Receptor Expression Profile of Human Dental Pulp Stem/Progenitor Cells. J Endod. 2016;42:413-7 pubmed publisher
    ..DPSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, and CD146 expression and for their multilineage differentiation potential...
  33. Dauwe D, Pelacho B, Wibowo A, Walravens A, Verdonck K, Gillijns H, et al. Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved. J Am Heart Assoc. 2016;5:e002288 pubmed publisher
    ..6±0.4 colonies/100×10(6) MNCs in CON (n=55; age: 34±1 years), P=0.29. Endothelial lineage (VEGFR2(+)/CD31(+)/CD146(+)) and progenitor (CD34(+)/CD133(-)) marker expression was comparable in ICMP and CON...
  34. Qiao Y, Qian Y, Wang J, Tang X. Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells. Oncol Lett. 2016;11:3702-3708 pubmed
    ..Recently, the membrane protein melanoma cell adhesion molecule (MCAM) was identified as a novel, hepatocellular carcinoma (HCC)-specific YAP target protein that promotes carcinogenesis ..
  35. Liu Y, Zhang J, Yu W, Zhang X, Wang G, Zhao Z. Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway. Oncotarget. 2016;7:81423-81434 pubmed publisher
    ..in cell proliferation (PDGFB, VEGFA), adhesion (ITGA1, ITGA2, ITGA3, ITGB3) and migration/invasion (PLAU, MMP9, MCAM, Dvl-2 and JNK)...
  36. Matak A, Lahiri P, Ford E, Pabst D, Kashofer K, Stellas D, et al. Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer. Hepatology. 2017;: pubmed publisher
    ..Transcriptome sequencing and immunohistochemical studies with the markers Zeb1 and CD146/MCAM demonstrated that switching between phenotypes is linked to changes in gene expression related but not ..
  37. Williams B, Schneider R, Jamal S. Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes. Melanoma Res. 2014;24:404-7 pubmed publisher
    Melanoma cell adhesion molecule (MCAM) is upregulated during melanoma progression, and associated with invasion and metastasis. Little is known about the factors that regulate MCAM expression in vivo...
  38. Kleb B, Estécio M, Zhang J, Tzelepi V, Chung W, Jelinek J, et al. Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas. Epigenetics. 2016;11:184-93 pubmed publisher
    ..the DNA methylation profiles of AR(-) and AR(+) PDX using methylated CpG island amplification and microarray (MCAM) analysis and identified a set of differentially methylated promoters, validated in PDX and corresponding donor ..
  39. Hasemann W, Grossmann F, Stadler R, Bingisser R, Breil D, Hafner M, et al. Screening and detection of delirium in older ED patients: performance of the modified Confusion Assessment Method for the Emergency Department (mCAM-ED). A two-step tool. Intern Emerg Med. 2018;13:915-922 pubmed publisher
    ..screening and assessment tool in our ED: the modified Confusion Assessment Method for the Emergency Department (mCAM-ED)...
  40. Chin C, Li S, Corselli M, Casero D, Zhu Y, He C, et al. Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports. 2018;10:436-446 pubmed publisher
    ..Despite co-expression of common mesenchymal markers (CD73, CD105, CD90, and PDGFRβ), a subset of cells defined as CD146hiCD73hi expressed genes associated with the HSPC niche and supported the maintenance of ..
  41. Zigler M, Villares G, Dobroff A, Wang H, Huang L, Braeuer R, et al. Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res. 2011;71:3494-504 pubmed publisher
    ..metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear...
  42. Bu P, Zhuang J, Feng J, Yang D, Shen X, Yan X. Visualization of CD146 dimerization and its regulation in living cells. Biochim Biophys Acta. 2007;1773:513-20 pubmed
    Our previous study showed that the adhesion molecule CD146 as a biomarker is over-expressed on activated endothelium during angiogenesis, which was induced by tumor conditional medium and inhibited by anti-CD146 monoclonal antibody (mAb ..
  43. Liu D, Du L, Chen D, Ye Z, Duan H, Tu T, et al. Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/?-catenin signaling. Oncotarget. 2016;7:40704-40718 pubmed publisher
    ..Here, we show that CD146 knockdown induces stem cell properties in colorectal cancer (CRC) cells through activating canonical Wnt signaling...
  44. Kratzer A, Chu H, Salys J, Moumen Z, Leberl M, Bowler R, et al. Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. J Pathol. 2013;230:388-98 pubmed publisher
    b>CD146 is an adhesion molecule localized at endothelial cell junctions and facilitates cell-cell interactions. The circulating soluble form (sCD146) lacks both the intracellular and the transmembrane domains...
  45. Fawzy El Sayed K, Mekhemar M, Adam Klages S, Kabelitz D, Dörfer C. TlR expression profile of human gingival margin-derived stem progenitor cells. Med Oral Patol Oral Cir Bucal. 2016;21:e30-8 pubmed
    ..G-MSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, CD146 and STRO-1 expression, and for multilineage differentiation potential...
  46. Zimmerlin L, Rubin J, Pfeifer M, Moore L, Donnenberg V, Donnenberg A. Human adipose stromal vascular cell delivery in a fibrin spray. Cytotherapy. 2013;15:102-8 pubmed publisher
    ..Under angiogenic conditions, SVF cells formed endothelial (vWF+, CD31+ and CD34+) tubules surrounded by CD146+ and α-smooth muscle actin+ perivascular/stromal cells...
  47. Muñoz Fernández R, De La Mata C, Prados A, Perea A, Ruiz Magaña M, Llorca T, et al. Human predecidual stromal cells have distinctive characteristics of pericytes: Cell contractility, chemotactic activity, and expression of pericyte markers and angiogenic factors. Placenta. 2018;61:39-47 pubmed publisher
    ..of decidual sections revealed the expression of antigens detected in preDSC lines: ?-SM actin colocalized with CD146, CD140b, MFG-E8, nestin, and STRO-1 (all of which are pericyte markers) in cells located around the vessels, a ..
  48. Mishra S, Khushu S, Gangenahalli G. Biological effects of iron oxide-protamine sulfate complex on mesenchymal stem cells and its relaxometry based labeling optimization for cellular MRI. Exp Cell Res. 2017;351:59-67 pubmed publisher
    ..Marginal alteration in Oct4 and CD146 genes, and phenotypic CD45 expressions were detected after labeling...
  49. Zhang S, Ba K, Wu L, Lee S, Peault B, Petrigliano F, et al. Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds. J Biomed Nanotechnol. 2015;11:1799-807 pubmed
    ..The aim of this study was to investigate the roles of pericytes (CD31(neg)CD45(neg)CD146+CD34(neg)) and adventitial cells (CD31(neg)CD45(neg)CD146(neg)CD34+) sub-populations of MSCs in supporting ..
  50. Jiang G, Zhang L, Zhu Q, Bai D, Zhang C, Wang X. CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma. J Exp Clin Cancer Res. 2016;35:38 pubmed publisher
    ..Recurrence and metastasis after curative resection remain critical obstacles in HCC treatment. CD146 predicted poor prognosis of a variety of cancers including melanoma, breast tumors, prostate cancer, and gastric ..
  51. Nielsen M, Mortensen M, Detlefsen S. Identification of markers for quiescent pancreatic stellate cells in the normal human pancreas. Histochem Cell Biol. 2017;148:359-380 pubmed publisher
    ..Cores with normal human liver served as control. Antibodies directed against adipophilin, ?-SMA, CD146, CRBP-1, cytoglobin, desmin, GFAP, nestin, S100A4 and vinculin were examined, with special emphasis on their ..
  52. Shan X, Chan R, Ng E, Yeung W. Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle. Exp Cell Res. 2017;350:184-189 pubmed publisher
    ..and deep portions of the endometrium) has an effect on stem cell activities of eMSCs (CD140b+CD146+ cells)...
  53. Wei Q, Tang Y, Voisin V, Sato S, Hirata M, Whetstone H, et al. Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma. Oncotarget. 2015;6:40283-94 pubmed publisher
    ..Here, we performed a high-throughput cell surface antigen screen and found that CD146 is enriched in the SP population...
  54. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, et al. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009;69:1570-7 pubmed publisher
    ..Here, we report the identification of MCAM/MUC18/CD146 as the surface antigen bound by one of the mesothelioma-targeting scFvs using a novel cloning strategy based on ..
  55. Persichini T, Funari A, Colasanti M, Sacchetti B. Clonogenic, myogenic progenitors expressing MCAM/CD146 are incorporated as adventitial reticular cells in the microvascular compartment of human post-natal skeletal muscle. PLoS ONE. 2017;12:e0188844 pubmed publisher
    ..In this study, we used MCAM/CD146, as a marker to localize, isolate and assay subendothelial clonogenic cells from the microvasculature of postnatal ..
  56. Schneider Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, et al. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med. 2014;211:1833-46 pubmed publisher
    ..healthy central-/effector-memory ratios, but lacked CD49d and showed enhanced myeloma cell adhesion molecule (MCAM) expression. LTNT led to an increase of PSGL-1 expression on peripheral T cells...
  57. Hu J, Yuan R. The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps. Med Sci Monit. 2011;17:BR221-227 pubmed
    To investigate the expression levels of importin13 (IPO13), c-kit, CD146, telomerase, caspase-3, bcl-2 and bax in endometrial polyps (EPs).
  58. Mishra R, Thorat D, Soundararajan G, Pradhan S, Chakraborty G, Lohite K, et al. Semaphorin 3A upregulates FOXO 3a-dependent MelCAM expression leading to attenuation of breast tumor growth and angiogenesis. Oncogene. 2015;34:1584-95 pubmed publisher
    ..Our study demonstrated a novel mechanism of regulation of tumor suppression by Sema 3A in coordination with a chain of tumor-suppressor genes, which in turn inhibits breast cancer cell migration, tumor growth and angiogenesis. ..
  59. Espagnolle N, Guilloton F, Deschaseaux F, Gadelorge M, Sensebe L, Bourin P. CD146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment. J Cell Mol Med. 2014;18:104-14 pubmed publisher
    ..In addition, MSCs vary in their proliferation capacity and expression of markers. Because of heterogeneity of CD146 expression in the MSC population, we compared CD146(-/Low) and CD146(High) cells under clonal conditions and after ..
  60. Ruma I, Putranto E, Kondo E, Murata H, Watanabe M, Huang P, et al. MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-?B and ROS formation upon ligand binding. Clin Exp Metastasis. 2016;33:609-27 pubmed publisher
    ..has recently been identified as an adhesion molecule and has considerably high identity and similarity to ALCAM and MCAM, which are frequently over-expressed on metastatic malignant melanoma cells...
  61. He Q, Scott Swindle C, Wan C, Flynn R, Oster R, Chen D, et al. Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic Progeny. Stem Cells. 2017;35:473-484 pubmed publisher
    ..a murine BM MSC subpopulation that was uniformly Nestin+ Lepr + Sca-1+ CD146+ and could be stably propagated with high colony-forming unit fibroblast re-cloning efficiency...
  62. Ishikawa T, Wondimu Z, Oikawa Y, Ingerpuu S, Virtanen I, Patarroyo M. Monoclonal antibodies to human laminin ?4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of ?6?1 integrin and MCAM to ?4-laminins. Matrix Biol. 2014;36:5-14 pubmed publisher
    ..These laminins are recognized by ?6?1 and ?6?4 integrins and MCAM (CD146), and promote adhesion and migration of the cells...
  63. Mohammadi M, Nejatollahi F, Ghasemi Y, Faraji S. Anti-Metastatic and Anti-Invasion Effects of a Specific Anti-MUC18 scFv Antibody on Breast Cancer Cells. Appl Biochem Biotechnol. 2017;181:379-390 pubmed publisher
    Breast cancer is the most common malignancy in women. Altered expression of MUC18, a cell surface receptor, and its interaction with Wnt-5a as its ligand, affects the motility and invasiveness of breast cancer cells...
  64. Liang Y, Zeng D, Xiao Y, Wu Y, Ouyang Y, Chen M, et al. MCAM/CD146 promotes tamoxifen resistance in breast cancer cells through induction of epithelial-mesenchymal transition, decreased ER? expression and AKT activation. Cancer Lett. 2017;386:65-76 pubmed publisher
    ..We found that melanoma cell adhesion molecule (MCAM/CD146), a unique epithelial-to-mesenchymal transition (EMT) inducer, was significantly up-regulated at both mRNA and ..
  65. Tripodo C, Di Bernardo A, Ternullo M, Guarnotta C, Porcasi R, Ingrao S, et al. CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis. Haematologica. 2009;94:127-30 pubmed publisher
    b>CD146(+) bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment...
  66. Lee N, Kim S, Yang S, Joo S, Park H, Lee K, et al. Comparative characterization of mesenchymal stromal cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule. Cytotherapy. 2017;19:170-180 pubmed publisher
    ..However, subcutaneous adipose tissue-derived MSCs have a faster growth rate and a higher level of CD146 expression than the other MSCs...
  67. Kwon O, Miller S, Li N, Khan A, Kadry Z, Uemura T. Bone marrow-derived endothelial progenitor cells and endothelial cells may contribute to endothelial repair in the kidney immediately after ischemia-reperfusion. J Histochem Cytochem. 2010;58:687-94 pubmed publisher
    ..We found that the numbers of circulating CD34-positive EPCs and CD146-positive endothelial cells (ECs) decreased immediately after ischemia-reperfusion...
  68. Kikalishvili N, Beriashvili R, Muzashvili T, Burkadze G. AGE-RELATED SPECIFICITIES OF ENDOMETRIAL PROLIFERATION/STEM CELL INDEX DISTRIBUTION. Georgian Med News. 2017;:99-104 pubmed
    ..Hematoxilyn-eosin technology and immunohistochemistry with proliferation marker Ki67 and stem cell marker CD146 was performed...
  69. Thomann S, Longerich T, Bazhin A, Mier W, Schemmer P, Ryschich E. Selective targeting of liver cancer with the endothelial marker CD146. Oncotarget. 2014;5:8614-24 pubmed
    ..b>CD146, a molecule expressed on the endothelial surface of hepatocellular carcinoma, was identified as a promising ..
  70. Pardo M, Garcia A, Thomas B, Piñeiro A, Akoulitchev A, Dwek R, et al. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int J Cancer. 2006;119:1014-22 pubmed
    ..Our data indicate a correlation between MUC18 and HMG-1 expression and the invasiveness of UM cells...
  71. Lai K, Sharma V, Jager M, Conway R, Madigan M. Expression and distribution of MUC18 in human uveal melanoma. Virchows Arch. 2007;451:967-76 pubmed
    The immunoglobulin superfamily protein MUC18 is involved in transendothelial migration and signal transduction, and is expressed in malignancies including cutaneous melanoma...
  72. Jin H, Kwon J, Kim M, Bae Y, Choi S, Oh W, et al. Downregulation of Melanoma Cell Adhesion Molecule (MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells. Stem Cells Transl Med. 2016;5:427-39 pubmed publisher
    ..Among these surface proteins, we selected the melanoma cell adhesion molecule (MCAM/CD146) for further study with the aim of validating observed expression differences and investigating the associated ..
  73. Kwak G, Kim D, Nam G, Wang S, Kim I, Kim S, et al. Programmed Cell Death Protein Ligand-1 Silencing with Polyethylenimine-Dermatan Sulfate Complex for Dual Inhibition of Melanoma Growth. ACS Nano. 2017;11:10135-10146 pubmed publisher
    ..polyethylenimine (CLPEI) and dermatan sulfate (DS), which we previously found to have a specific interaction with CD146-positive B16F10 melanoma cells...
  74. Sato A, Torii I, Okamura Y, Yamamoto T, Nishigami T, Kataoka T, et al. Immunocytochemistry of CD146 is useful to discriminate between malignant pleural mesothelioma and reactive mesothelium. Mod Pathol. 2010;23:1458-66 pubmed publisher
    ..Increased expression of CD146, a cell adhesion molecule, has been reported to be closely associated with an advanced stage of malignant melanoma,..
  75. Shih I, Elder D, Speicher D, Johnson J, Herlyn M. Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res. 1994;54:2514-20 pubmed
    ..Tryptic peptides of the A32 antigen obtained after immunoaffinity chromatography showed sequence identity to MUC18 antigen, a member of the immunoglobulin supergene family...