MBP

Summary

Gene Symbol: MBP
Description: myelin basic protein
Alias: myelin basic protein, Golli-MBP, proline-rich proteoglycan 2, myelin A1 protein, myelin membrane encephalitogenic protein
Species: human
Products:     MBP

Top Publications

  1. Ridsdale R, Beniac D, Tompkins T, Moscarello M, Harauz G. Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis. J Biol Chem. 1997;272:4269-75 pubmed
    A computational model of myelin basic protein (MBP) has been constructed based on the premise of a phylogenetically conserved beta-sheet backbone and on electron microscopical three-dimensional reconstructions...
  2. Belogurov A, Kudriaeva A, Kuzina E, Smirnov I, Bobik T, Ponomarenko N, et al. Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation. J Biol Chem. 2014;289:17758-66 pubmed publisher
    ..Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a ubiquitin-independent manner both in vitro and in mammalian ..
  3. Kishimoto A, Nishiyama K, Nakanishi H, Uratsuji Y, Nomura H, Takeyama Y, et al. Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem. 1985;260:12492-9 pubmed
    ..and compared with that of cyclic AMP-dependent protein kinase (protein kinase A) by using bovine brain myelin basic protein as a model substrate...
  4. Ponomarenko N, Durova O, Vorobiev I, Belogurov A, Kurkova I, Petrenko A, et al. Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen. Proc Natl Acad Sci U S A. 2006;103:281-6 pubmed
    ..We detected proteolytic activity toward myelin basic protein (MBP) in the fraction of antibodies purified from the sera of humans with multiple sclerosis (MS) and mice ..
  5. Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale T, Tan P, et al. Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology. 2012;119:1874-85 pubmed publisher
    ..This locus explains a small proportion of the excess sibling correlation for advanced AMD subtype. Other loci were detected with suggestive associations that differ for advanced AMD subtypes and deserve follow-up in additional studies. ..
  6. Kamholz J, de Ferra F, Puckett C, Lazzarini R. Identification of three forms of human myelin basic protein by cDNA cloning. Proc Natl Acad Sci U S A. 1986;83:4962-6 pubmed
    We have isolated cDNA clones encoding three separate forms of human myelin basic protein (MBP), 21.5, 18.5, and 17.2 kDa, and have determined the nucleotide sequence of each...
  7. Pribyl T, Campagnoni C, Kampf K, Kashima T, Handley V, McMahon J, et al. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc Natl Acad Sci U S A. 1993;90:10695-9 pubmed
    Two human Golli (for gene expressed in the oligodendrocyte lineage)-MBP (for myelin basic protein) cDNAs have been isolated from a human oligodendroglioma cell line...
  8. D Souza C, Moscarello M. Differences in susceptibility of MBP charge isomers to digestion by stromelysin-1 (MMP-3) and release of an immunodominant epitope. Neurochem Res. 2006;31:1045-54 pubmed
    Charge microheterogeneity of myelin basic protein is known to affect its conformation and function...
  9. Majava V, Wang C, Myllykoski M, Kangas S, Kang S, Hayashi N, et al. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids. 2010;39:59-71 pubmed publisher
    b>Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution...

More Information

Publications139 found, 100 shown here

  1. Zarinfard G, Tadjalli M, Razavi S, Kazemi M. Effect of Laminin on Neurotrophic Factors Expression in Schwann-Like Cells Induced from Human Adipose-Derived Stem Cells In Vitro. J Mol Neurosci. 2016;60:465-473 pubmed
    ..The analysis of GFAP/S100? and S100?/MBP markers indicate that laminin can increase the differentiated rate and myelinogenic potential of SC-like cells...
  2. Seiberlich V, Bauer N, Schwarz L, Ffrench Constant C, Goldbaum O, Richter Landsberg C. Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia. 2015;63:1621-35 pubmed publisher
    ..the expression of the proteoglycan NG2, and acquire major myelin specific proteins, such as myelin basic proteins (MBP) and proteolipid protein...
  3. Xu D, Bechtner J, Behr J, Eisenbach L, Geißler A, Vogel R. Lifestyle of Lactobacillus hordei isolated from water kefir based on genomic, proteomic and physiological characterization. Int J Food Microbiol. 2019;290:141-149 pubmed publisher
    ..hordei TMW 1.1822 revealed one chromosome plus three plasmids. The size of the chromosome was 2.42 Mbp with a GC content of 35% GC and 2461 predicted coding sequences...
  4. Müller C, Hochhaus N, Fontana X, Luhmann H, White R. SncRNA715 Inhibits Schwann Cell Myelin Basic Protein Synthesis. PLoS ONE. 2015;10:e0136900 pubmed publisher
    Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS)...
  5. DeWitt J, Buck B, Goossens D, Hu Q, Chow R, David W, et al. Health effects following subacute exposure to geogenic dusts from arsenic-rich sediment at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicol Appl Pharmacol. 2016;304:79-89 pubmed publisher
    ..Splenic CD4+CD25+ T cells were decreased at 0.01, 0.1, 10, and 100mg/kg/day. Antibodies against MBP, NF-68, and GFAP were selectively reduced. A no observed adverse effect level of 0...
  6. Levite M. Glutamate, T cells and multiple sclerosis. J Neural Transm (Vienna). 2017;124:775-798 pubmed publisher
    ..MS patients, (3) Glutamate augments proliferation of T cells of MS patients in response to myelin-derived proteins: MBP and MOG, (4) T cells of MS patients respond abnormally to glutamate, (5) Significantly higher proliferation values ..
  7. Weil M, Mobius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, et al. Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep. 2016;16:314-322 pubmed publisher
    ..We demonstrated that myelin basic proteins (MBP), which form a polymer in between the myelin membrane layers, are targeted in these models...
  8. Moghadam M, Albersmeier A, Winkler A, Cimmino L, Rise K, Hohmann Marriott M, et al. Isolation and genome sequencing of four Arctic marine Psychrobacter strains exhibiting multicopper oxidase activity. BMC Genomics. 2016;17:117 pubmed publisher
    ..The genomes were assembled and revealed genome sizes between 3.29 and 3.52 Mbp with an average G + C content of around 42%, with one to seven plasmids present in the four strains...
  9. Lee M, Jang M, Choi J, Lee G, Min H, Chung W, et al. Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses. Mol Neurobiol. 2016;53:1419-1445 pubmed publisher
    ..ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein (MBP)(68-82)-induced acute experimental autoimmune encephalomyelitis (EAE) rat model...
  10. Holowachuk E, Ruhoff M. Biologically active recombinant rat granulocyte macrophage colony-stimulating factor produced in Escherichia coli. Protein Expr Purif. 1995;6:588-96 pubmed
    ..The synthesis of R-rGM-CSF was directed by a modified, inducible maltose binding protein (MBP) gene fusion expression vector, pMTR-23, and secreted to the periplasm...
  11. Sasatomi Y, Kaneoka H, Abe Y, Ishimura A, Ogahara S, Murata T, et al. Anemia and hypertension are risk factors for both renal prognosis and survival in patients with diabetes mellitus. Clin Exp Nephrol. 2009;13:473-479 pubmed publisher
    ..months), body mass index (BMI) (kg/m(2)) [body weight/(body height)(2)], age (years), mean blood pressure (mBP) (mmHg) [diastolic BP + (systolic BP - diastolic BP)/3], serum levels of albumin (mg/dl), urea nitrogen (BUN) (mg/..
  12. Hughes R, Zhang Y, Zhang R, Williams P, Lindsey J, Miller E. Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..The finished, closed HT-58-2Cyano genome consists of 7.85 Mbp (42.6% G+C) and contains 6,581 genes. All genes for biosynthesis of tetrapyrroles (e.g...
  13. Musik J, Zalucki Y, Day C, Jennings M. Efficient function of signal peptidase 1 of Escherichia coli is partly determined by residues in the mature N-terminus of exported proteins. Biochim Biophys Acta Biomembr. 2019;1861:1018-1022 pubmed publisher
    ..Maltose binding protein (MBP) was mutated to introduce aromatic amino acids (tryptophan, tyrosine and phenylalanine) at P2'...
  14. Grgic M, Williamson A, Kjæreng Bjerga G, Altermark B, Leiros I. Biochemical characterization of ParI, an orphan C5-DNA methyltransferase from Psychrobacter arcticus 273-4. Protein Expr Purif. 2018;150:100-108 pubmed publisher
    ..Both recombinant and native ParI showed methyltransferase activity in vivo. In addition, MBP- and His-tagged ParI also demonstrated in vitro activity...
  15. Fan J, Ning K, Zeng X, Luo Y, Wang D, Hu J, et al. Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp. Plant Physiol. 2015;169:2444-61 pubmed publisher
    ..To probe this mechanism, we sequenced the 56.8-Mbp genome of Chlorella pyrenoidosa FACHB-9, an industrial production strain for protein, starch, and lipids...
  16. Hunt N, Waters K, Machaalani R. Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. Mol Neurobiol. 2017;54:7171-7185 pubmed publisher
    ..3 (CC3), cleaved caspase 9 (CC9), glial fibrillary acid protein (GFAP), tubulin beta chain 3 (TUBB3), myelin basic protein (MBP), interleukin 1β (IL-1β), terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL), c-..
  17. Lee S, Park S, Kim Y. Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli. AMB Express. 2015;5:142 pubmed publisher
    ..as FST288, NDFSD1/2, NDFSD1, and NDFSD1/1, into pMALc5x vector downstream of the maltose-binding protein (MBP) gene, and the plasmids containing the inserts were eventually transformed into Shuffle E...
  18. Starr E, Shi S, Blazewicz S, Probst A, Herman D, Firestone M, et al. Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon. Microbiome. 2018;6:122 pubmed publisher
    ..A 1.45-Mbp genome of a Saccharibacteria (TM7) was identified and, despite the microbial complexity of rhizosphere soil, ..
  19. Berdasco C, Pinto A, Calabró V, Arenas D, Cangelosi A, Geoghegan P, et al. Shiga toxin 2 from enterohemorrhagic Escherichia coli induces reactive glial cells and neurovascular disarrangements including edema and lipid peroxidation in the murine brain hippocampus. J Biomed Sci. 2019;26:16 pubmed publisher
    ..to immunofluorescence with lectins to determine the microvasculature profile, and anti-GFAP, anti-NeuN, anti-MBP and anti-Iba1 to study reactive astrocytes, neuronal damage, myelin dysarrangements and microglial state ..
  20. Satar B, Hidir Y, Serdar M, Kucuktag Z, Ural A, Avcu F, et al. Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells. Cytotherapy. 2012;14:522-8 pubmed publisher
    ..Our aim was to compare apoptosis scores and the expression of myelin-associated glycoprotein (MAG), myelin basic protein (MBP), neural cell adhesion molecule (NCAM)-1,matrix metalloproteinase (MMP)-1A, tissue inhibitor of ..
  21. Wu C, Jordan M, Newcomb R, Gemmell N, Bank S, Meusemann K, et al. Analysis of the genome of the New Zealand giant collembolan (Holacanthella duospinosa) sheds light on hexapod evolution. BMC Genomics. 2017;18:795 pubmed publisher
    ..duospinosa and potential horizontal gene transfer events. Our genome assembly was ~375 Mbp in size with a scaffold N50 of ~230 Kbp and sequencing coverage of ~180×...
  22. Nilojan J, Bathige S, Kugapreethan R, Thulasitha W, Nam B, Lee J. Molecular, transcriptional and functional insights into duplicated goose-type lysozymes from Sebastes schlegelii and their potential immunological role. Fish Shellfish Immunol. 2017;67:66-77 pubmed publisher
    ..Turbidimetric assays indicated that both recombinant proteins tagged with maltose-binding protein (MBP) were reactive against several Gram-positive and Gram-negative bacteria, but MBP was inactive...
  23. Persike D, Marques Carneiro J, Stein M, Yacubian E, Centeno R, Canzian M, et al. Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy. Pharmaceuticals (Basel). 2018;11: pubmed publisher
    ..A (ATP6V1A), heat shock protein 70 (HSP70), dihydropyrimidinase-related protein 2 (DPYSL2), isoform 1 of myelin basic protein (MBP), and dihydrolipoamide S-acethyltransferase (DLAT)...
  24. Hahn K, Neumeister K, Mix A, Kottke T, Groger H, Fischer von Mollard G. Recombinant expression and characterization of a L-amino acid oxidase from the fungus Rhizoctonia solani. Appl Microbiol Biotechnol. 2017;101:2853-2864 pubmed publisher
    ..L-AAO from the fungus Rhizoctonia solani in Escherichia coli as a fusion protein with maltose-binding protein (MBP) as a solubility tag...
  25. Zhuang X, Murphy K, Ghigliotti L, Pisano E, Cheng C. Reconstruction of the repetitive antifreeze glycoprotein genomic loci in the cold-water gadids Boreogadus saida and Microgadus tomcod. Mar Genomics. 2018;39:73-84 pubmed publisher
    ..6?kbp. The genome sizes of B. saida and M. tomcod were estimated by cell flow cytometry to be 836?Mbp and 645?Mbp respectively, thus their BAC libraries have approximately 10- and 9.7-fold genome coverage respectively...
  26. Adiele R, Adiele C. Metabolic defects in multiple sclerosis. Mitochondrion. 2019;44:7-14 pubmed publisher
    ..Loss of myelin proteins including myelin basic protein (MBP), proteolipid protein (PLP), myelin associated glycoprotein (MAG), myelin oligodendrocyte glycoproetin ..
  27. Bermejo G, Strub M, Ho C, Tjandra N. Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein. Biochemistry. 2010;49:1893-902 pubmed publisher
    ..Evidence for the latter has been recently reported on maltose-binding protein (MBP) in aqueous solution [Tang, C., et al...
  28. McVie A, Ersfeld K, Rogan M, Craig P. Expression and immunological characterisation of Echinococcus granulosus recombinant antigen B for IgG4 subclass detection in human cystic echinococcosis. Acta Trop. 1997;67:19-35 pubmed
    ..A 52 kDa maltose binding-AgB fusion protein (rAgB.MBP) was produced and inclusion bodies containing the fusion protein were solubilised in urea and affinity purified on ..
  29. Nguyen A, Song J, Nguyen M, Do B, Kwon G, Park S, et al. Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein. Sci Rep. 2017;7:16139 pubmed publisher
    ..Trx), small ubiquitin-related modifier (Sumo), glutathione S-transferase (GST), maltose-binding protein (MBP), N-utilisation substance protein A (NusA), human protein disulphide isomerase (PDI), and the b'a' domain of PDI (..
  30. Potamitis C, Matsoukas M, Tselios T, Mavromoustakos T, Golic Grdadolnik S. Conformational analysis of the ???83-99 (Phe91) and ???83-99 (Tyr91) peptide analogues and study of their interactions with the HLA-DR2 and human TCR receptors by using molecular dynamics. J Comput Aided Mol Des. 2011;25:837-53 pubmed publisher
    The two new synthetic analogues of the MBP(83-99) epitope substituted at Lys(91) (primary TCR contact) with Phe [MBP(83-99) (Phe(91))] or Tyr [MBP(83-99) (Tyr(91))], have been structurally elucidated using 1D and 2D high resolution NMR ..
  31. Minarovits J, Banati F, Szenthe K, Niller H. Epigenetic Regulation. Adv Exp Med Biol. 2016;879:1-25 pubmed publisher
    ..active demethylation of 5-metylcytosine (5mC) are outlined together with the members of the methyl binding protein (MBP) family that bind to and "interpret" the 5mC mark...
  32. Gumpena R, Lountos G, Raran Kurussi S, Tropea J, Cherry S, Waugh D. Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Sci. 2018;27:561-567 pubmed publisher
    ..49 Å resolution. Uniquely, the protein was crystallized as an MBP fusion protein in complex with a monobody that binds to MBP...
  33. Piñero G, Usach V, Soto P, Monje P, Setton Avruj P. EGFP transgene: a useful tool to track transplanted bone marrow mononuclear cell contribution to peripheral remyelination. Transgenic Res. 2018;27:135-153 pubmed publisher
    ..expression levels of markers specific to multipotent progenitors (CD34, CD90 and CD105) and Schwann cells (MPZ, MBP, S100β and p75NTR) compared to wild type BMMC...
  34. Park J, Choi H, Cho J, Kim I, Lee T, Lee J, et al. Effects of Chronic Scopolamine Treatment on Cognitive Impairments and Myelin Basic Protein Expression in the Mouse Hippocampus. J Mol Neurosci. 2016;59:579-89 pubmed publisher
    ..b>Myelin basic protein (MBP) is one of the most abundant structural proteins in myelin and is essential for myelin formation and ..
  35. Love J, Bober B, Orozco E, White A, Bremner S, Lovering R, et al. mTOR regulates peripheral nerve response to tensile strain. J Neurophysiol. 2017;117:2075-2084 pubmed publisher
    ..in significant upregulation of mammalian target of rapamycin (mTOR) and S6 signaling in nerves, increased myelin basic protein (MBP) and β-actin levels, and increased phosphorylation of neurofilament subunit H (NF-H) compared with ..
  36. Hoshikawa M, Kato A, Hojo H, Shibata Y, Kumamoto N, Watanabe M, et al. Distribution of ASIC4 transcripts in the adult wild-type mouse brain. Neurosci Lett. 2017;651:57-64 pubmed publisher
    ..on wild-type mouse brains, followed by X-gal staining experiments with Asic4-lacZ reporter mice Asic4tm1a(KOMP)Mbp...
  37. Hemmer W, Altmann F, Holzweber F, Gruber C, Wantke F, Wöhrl S. ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels. J Allergy Clin Immunol. 2018;141:372-381.e3 pubmed publisher
    ..of blank ImmunoCAPs coupled to either streptavidin (SA-CAP-1 or 2) or nonallergenic maltose-binding protein (MBP; MBP-CAP-1 to 4) and binding to a panel of 4 recombinant allergens were compared in CCD-positive sera before and ..
  38. Collier D, Strobel S, Bassford P. SecB-independent export of Escherichia coli ribose-binding protein (RBP): some comparisons with export of maltose-binding protein (MBP) and studies with RBP-MBP hybrid proteins. J Bacteriol. 1990;172:6875-84 pubmed
    The efficient export of the Escherichia coli maltose-binding protein (MBP) is known to be SecB dependent, whereas ribose-binding protein (RBP) export is SecB independent...
  39. Duplay P, Szmelcman S, Bedouelle H, Hofnung M. Silent and functional changes in the periplasmic maltose-binding protein of Escherichia coli K12. I. Transport of maltose. J Mol Biol. 1987;194:663-73 pubmed
    The malE gene encodes the periplasmic maltose-binding protein (MBP)...
  40. Baldwin G, Carnegie P. Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin. Science. 1971;171:579-81 pubmed
    ..Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin. ..
  41. Arvanitis D, Yang W, Boggs J. Myelin proteolipid protein, basic protein, the small isoform of myelin-associated glycoprotein, and p42MAPK are associated in the Triton X-100 extract of central nervous system myelin. J Neurosci Res. 2002;70:8-23 pubmed
    To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-..
  42. Chi A, McGuire B, Nadler R. Modern Guidelines for Bowel Preparation and Antimicrobial Prophylaxis for Open and Laparoscopic Urologic Surgery. Urol Clin North Am. 2015;42:429-40 pubmed publisher
    Mechanical bowel preparation (MBP) and antibiotics (oral and/or intravenous) have historically been used to decrease infectious complications in surgeries that involve manipulation of bowel or potential risk of injury...
  43. Kondo Y, Hirose N, Maeda T, Suzuki T, Yoshino A, Katayama Y. Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol. Adv Exp Med Biol. 2016;876:479-484 pubmed publisher
    ..05). Changes in deoxy-Hb, MBP, and HR did not differ between the groups...
  44. Rice F, Xie J, Albrecht P, Acker E, Bourgeois J, Navratilova E, et al. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Cephalalgia. 2016;: pubmed
    ..Slightly-larger caliber NF200-positive fibers co-labeled for myelin basic protein (MBP) and terminated as unbranched corpuscular endings...
  45. Dubreuil J, Letellier A, Harel J. A recombinant Escherichia coli heat-stable enterotoxin b (STb) fusion protein eliciting neutralizing antibodies. FEMS Immunol Med Microbiol. 1996;13:317-23 pubmed
    ..The maltose binding protein (MBP) of E. coli was used as a carrier for STb, a poorly immunogenic molecule...
  46. Gould A, Shilton B. Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate. J Biol Chem. 2010;285:11290-6 pubmed publisher
    ..activity of the maltose transporter (MalFGK(2)) is dependent on interactions with the maltose-binding protein (MBP)...
  47. Walsh C, Doherty M, Tepikin A, Burgoyne R. Evidence for an interaction between Golli and STIM1 in store-operated calcium entry. Biochem J. 2010;430:453-60 pubmed publisher
    ..It was reported previously that Golli-BG21, a member of the MBP (myelin basic protein) family of proteins, regulates SOCE (store-operated Ca(2+) entry) in T-cells and oligodendrocyte precursor ..
  48. Skallerup P, Nejsum P, Jørgensen C, Goring H, Karlskov Mortensen P, Archibald A, et al. Detection of a quantitative trait locus associated with resistance to Ascaris suum infection in pigs. Int J Parasitol. 2012;42:383-91 pubmed
    ..suum. A putative quantitative trait locus for worm burden on chromosome 4 covering 2.5 Mbp was identified by measured genotype analysis, although none of the SNPs reached genome-wide significance...
  49. Bao X, Zhu W, Yuan W, Zhu X, Yan Y, Tang H, et al. Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists. Eur J Med Chem. 2016;123:115-127 pubmed publisher
    ..62 ± 4.08 mmHg of MBP at 15 mg/kg and 28.39 ± 2.09 mmHg at 10 mg/kg in SHRs, 39.56 ± 4.83 mmHg at 15 mg/kg and 29.05 ± 2...
  50. Mongodin E, Hittle L, Nadendla S, Brinkman C, Xiong Y, Bromberg J. Complete Genome Sequence of a Strain of Bifidobacterium pseudolongum Isolated from Mouse Feces and Associated with Improved Organ Transplant Outcome. Genome Announc. 2017;5: pubmed publisher
    Here, we report the complete genome sequence of Bifidobacterium pseudolongum strain UMB-MBP-01, isolated from the feces of C57BL/6J mice...
  51. Li J, Kustu S, Stewart V. In vitro interaction of nitrate-responsive regulatory protein NarL with DNA target sequences in the fdnG, narG, narK and frdA operon control regions of Escherichia coli K-12. J Mol Biol. 1994;241:150-65 pubmed
    ..To examine NarL-DNA interactions, we purified the NarL protein as a maltose binding protein (MBP) fusion protein (MBP-NarL)...
  52. Ribeiro A, Golicz A, Hackett C, Milne I, Stephen G, Marshall D, et al. An investigation of causes of false positive single nucleotide polymorphisms using simulated reads from a small eukaryote genome. BMC Bioinformatics. 2015;16:382 pubmed publisher
    ..The variation in the number of FP SNPs generated ranged from 0 to 36,621 for the 120 million base pairs (Mbp) genome...
  53. Oshone R, Hurst S, Abebe Akele F, Simpson S, Morris K, Thomas W, et al. Permanent Draft Genome Sequences for Two Variants of Frankia sp. Strain CpI1, the First Frankia Strain Isolated from Root Nodules of Comptonia peregrina. Genome Announc. 2016;4: pubmed publisher
    ..Here, we report two 7.6-Mbp draft genome sequences with 6,396 and 6,373 candidate protein-coding genes for CpI1-S and CpI1-P, respectively.
  54. Halstrom A, Macdonald E, Neil C, Arendts G, Fatovich D, Fitzgerald M. Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury. J Clin Neurosci. 2017;35:104-108 pubmed publisher
    ..of varying severity, quantifies circulating concentrations of the structural damage indicators S100b, and myelin basic protein (MBP), and the biomarkers of oxidative stress hydroxynonenal (HNE), malondialdehyde (MDA), carboxy-methyl-..
  55. Brawley S, Blouin N, Ficko Blean E, Wheeler G, Lohr M, Goodson H, et al. Insights into the red algae and eukaryotic evolution from the genome of Porphyra umbilicalis (Bangiophyceae, Rhodophyta). Proc Natl Acad Sci U S A. 2017;114:E6361-E6370 pubmed publisher
    ..Here we present the 87.7-Mbp haploid Porphyra genome (65...
  56. Chen Q, Yin D, Jia Y, Schiwy S, Legradi J, Yang S, et al. Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish. Sci Total Environ. 2017;609:1312-1321 pubmed publisher
    ..It was found that either BPA or NPPs can cause myelin basic protein (MBP)/gene up-regulation in the central nervous system (CNS); meanwhile, both contaminants exhibited ..
  57. Grana X, De Luca A, Sang N, Fu Y, Claudio P, Rosenblatt J, et al. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A. 1994;91:3834-8 pubmed
    ..Interestingly, the retinoblastoma kinase activity associated with PITALRE does not oscillate during the cell cycle. ..
  58. Currie D, Raman B, Gowen C, Tschaplinski T, Land M, Brown S, et al. Genome-scale resources for Thermoanaerobacterium saccharolyticum. BMC Syst Biol. 2015;9:30 pubmed publisher
    ..The genome consists of a 2.7 Mbp chromosome and a 110 Kbp megaplasmid...
  59. Câmara C, Araújo C, de Sousa K, Brito G, Vale M, Raposo R, et al. Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats. Neurosci Lett. 2015;607:52-58 pubmed publisher
    ..Another aim of this study was to evaluate GBP effects on myelin basic protein (MBP) on the 5th and 15th days post-injury and nerve morphology by transmission electron microscopy to ..
  60. Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz Brull R, Richter Landsberg C, et al. Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun. 2017;5:37 pubmed publisher
    ..An age and disease-dependent loss of myelin basic protein (MBP) signal was detected by immunohistochemistry in striatal striosomes (patches)...
  61. Poterlowicz K, Yarker J, Malashchuk I, Lajoie B, Mardaryev A, Gdula M, et al. 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells. PLoS Genet. 2017;13:e1006966 pubmed publisher
    Mammalian genomes contain several dozens of large (>0.5 Mbp) lineage-specific gene loci harbouring functionally related genes...
  62. Manohar M, Verma A, Venkateshaiah S, Mishra A. Role of eosinophils in the initiation and progression of pancreatitis pathogenesis. Am J Physiol Gastrointest Liver Physiol. 2018;314:G211-G222 pubmed publisher
    ..Additionally, we state that cerulein-induced chronic pancreatitis is independent of blood eosinophilia. ..
  63. Lim Y, Low B, Lim J, Wong E, Guy G. Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. J Biol Chem. 1999;274:19025-34 pubmed
    ..It is likely that FRS2 serves as an anchoring protein for targeting activated atypical PKCs to the cell plasma membrane in signaling pathways. ..
  64. Lin J, Chen H, Fang H, Robinson D, Kung H, Shih H. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 2001;20:6559-69 pubmed
    ..Wild-type but not kinase-dead MST4 can phosphorylate myelin basic protein in an in vitro kinase assay...
  65. García Pedraza J, García M, Martín M, Rodríguez Barbero A, Morán A. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascul Pharmacol. 2016;79:51-59 pubmed publisher
    ..00000125 to 0.1 μg/kg) decreased renal perfusion pressure (RPP) but did not affect the mean blood pressure (MBP). i.a...
  66. Figueroa K, Paul S, Calì T, Lopreiato R, Karan S, Frizzarin M, et al. Spontaneous shaker rat mutant - a new model for X-linked tremor/ataxia. Dis Model Mech. 2016;9:553-62 pubmed publisher
    ..genetic mapping of F2 sib-sib offspring using polymorphic markers narrowed the candidate gene region to 26 Mbp denoted by the last recombinant genetic marker DXRat21 at 133 Mbp to qter (the end of the long arm)...
  67. Velmurugan J, Mollison E, Barth S, Marshall D, Milne L, Creevey C, et al. An ultra-high density genetic linkage map of perennial ryegrass (Lolium perenne) using genotyping by sequencing (GBS) based on a reference shotgun genome assembly. Ann Bot. 2016;118:71-87 pubmed publisher
    ..570 Mbp of the gene-rich portion of the genome has been captured...
  68. Roth M, Cokus S, Gallaher S, Walter A, Lopez D, Erickson E, et al. Chromosome-level genome assembly and transcriptome of the green alga Chromochloris zofingiensis illuminates astaxanthin production. Proc Natl Acad Sci U S A. 2017;114:E4296-E4305 pubmed publisher
    ..of short- and long-read sequencing in conjunction with optical mapping, revealed a compact genome of ∼58 Mbp distributed over 19 chromosomes containing 15,274 predicted protein-coding genes...
  69. Kitomi Y, Nakao E, Kawai S, Kanno N, Ando T, Fukuoka S, et al. Fine Mapping of QUICK ROOTING 1 and 2, Quantitative Trait Loci Increasing Root Length in Rice. G3 (Bethesda). 2018;8:727-735 pubmed publisher
    ..7-Mb interval on chromosome 2, and QRO2 was mapped between markers RM20495 and RM3430-1, which delimit an 884-kb interval on chromosome 6. Both QTLs may be promising gene resources for improving root system architecture in rice. ..
  70. Sueoka Aragane N, Katakami N, Satouchi M, Yokota S, Aoe K, Iwanaga K, et al. Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study. Cancer Sci. 2016;107:162-7 pubmed publisher
    ..T790M was examined using the mutation-biased PCR and quenching probe (MBP-QP) method, a sensitive, fully-automated system developed in our laboratory...
  71. Lomakin Y, Belogurov A, Glagoleva I, Stepanov A, Zakharov K, Okunola J, et al. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-? and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients. Mediators Inflamm. 2016;2016:2847232 pubmed publisher
    We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE)...
  72. Lei X, Sun Y, Cai S, Fang Y, Cui J, Li Y. Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination. Int J Ophthalmol. 2016;9:831-7 pubmed publisher
    ..b>Myelin basic protein (mbp) was used as a marker to track and observe the myelination using whole-mount in situ hybridization...
  73. Benamar S, Cassir N, Caputo A, Cadoret F, La Scola B. Complete Genome Sequence of Clostridium septicum Strain CSUR P1044, Isolated from the Human Gut Microbiota. Genome Announc. 2016;4: pubmed publisher
    ..septicum strain CSUR P1044 isolated from the gut of a healthy adult. Its chromosome genome consists of 3.2 Mbp with a plasmid of 32 Kbp. C. septicum strain CSUR P1044 has a G+C content of 27...
  74. Lei X, Cai S, Chen Y, Cui J, Wang Y, Li Z, et al. Down-regulation of interleukin 7 receptor (IL-7R) contributes to central nervous system demyelination. Oncotarget. 2017;8:28395-28407 pubmed publisher
    ..We used a transgenic (Tg; mbp:nfsB-egfp) zebrafish line in which oligodendrocytes expressed green fluorescent protein (GFP) from the larval stage ..
  75. Hahn M, Schmidt J, Asiyo G, Kyrpides N, Woyke T, Whitman W. Reclassification of a Polynucleobacter cosmopolitanus strain isolated from tropical Lake Victoria as Polynucleobacter victoriensis sp. nov. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..Strains MWH-MoIso2T and MWH-VicM1 possess quite small genomes of 1.78 and 1.63 Mbp, respectively, and share similar G+C?values of 44.1 and 43.1?mol%, respectively...
  76. Pak M, Jung D, Lee H, Shin M, Kim S, Shin Y, et al. Combined therapy involving electroacupuncture and treadmill exercise attenuates demyelination in the corpus callosum by stimulating oligodendrogenesis in a rat model of neonatal hypoxia-ischemia. Exp Neurol. 2018;300:222-231 pubmed publisher
    ..TM exercise significantly restored corpus callosum thickness, and combined therapy with EA and TM restored myelin basic protein (MBP) levels in this region...
  77. Biswas R, Huntemann M, Clum A, Pillay M, Palaniappan K, Varghese N, et al. Complete Genome Sequence of Thermoanaerobacterium sp. Strain RBIITD, a Butyrate- and Butanol-Producing Thermophile. Genome Announc. 2018;6: pubmed publisher
    ..It primarily produces butyrate as a fermentation product from plant biomass-derived sugars. The whole-genome sequence of the strain is 3.4 Mbp, with 3,444 genes and 32.48% GC content.
  78. Vande Vyver M, Beelen R, de Keyser J, Nagels G, VAN Binst A, Verborgh C, et al. Plasma citrulline levels are increased in patients with multiple sclerosis. J Neurol Sci. 2018;387:174-178 pubmed publisher
    Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system (CNS). Myelin basic protein (MBP), which is one of the main compounds of CNS myelin, appears to be hypercitrullinated in the brain of patients with ..
  79. Vaurs Barriere C, Bonnet Dupeyron M, Combes P, Gauthier Barichard F, Reveles X, Schiffmann R, et al. Golli-MBP copy number analysis by FISH, QMPSF and MAPH in 195 patients with hypomyelinating leukodystrophies. Ann Hum Genet. 2006;70:66-77 pubmed
    ..The myelin basic protein (MBP) gene, which encodes the second most abundant CNS myelin protein after PLP1, presents rearrangements ..
  80. Tan B, Te S, Gin K, Thompson J. Draft Genome Sequence of a Tropical Freshwater Cyanobacterium, Limnothrix sp. Strain P13C2. Genome Announc. 2016;4: pubmed publisher
    ..strain P13C2 was obtained through multiple subculturing of an inoculum obtained from a tropical freshwater lake. Here, we report the genome of P13C2 of 4.6 Mbp, extracted from the metagenome of this coculture.
  81. Wada K, Mizuno S, Ohta H, Nishiyama Y. Immune response to neutralizing epitope on human cytomegalovirus gylcoprotein B in Japanese: correlation of serologic response with HLA-type. Microbiol Immunol. 1997;41:841-5 pubmed
    ..a fusion protein containing amino acid residues 549 to 644 of the gB polypeptide and maltose binding protein (MBP). Of 180 seropositive samples, 106 (58.9%) showed positive immuno-reactivity against the fusion protein...
  82. Simmons M, Murphy G, Hayes C. Short report: Antibody responses of mice immunized with a tetravalent dengue recombinant protein subunit vaccine. Am J Trop Med Hyg. 2001;65:159-61 pubmed
    Recombinant proteins containing the B domain of dengue virus serotypes 1-4 fused to the maltose binding protein (MBP) of Escherichia coli were evaluated individually and as a tetravalent vaccine candidate in mice...
  83. de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom M, Flanagan S, et al. A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes. EMBO Rep. 2008;9:648-54 pubmed publisher
    ..Functional analysis showed that this mutation decreases MgATP hydrolysis by purified maltose-binding protein MBP-NBD1 fusion proteins. Inhibition of ATP hydrolysis by MgADP or BeF was not changed...
  84. Nakamura N, Hirakawa H, Sato S, Otagaki S, Matsumoto S, Tabata S, et al. Genome structure of Rosa multiflora, a wild ancestor of cultivated roses. DNA Res. 2017;: pubmed publisher
    ..The total length of the scaffolds was 739,637,845?bp, consisting of 83,189 scaffolds, which was close to the 711 Mbp length estimated by k-mer analysis...
  85. Yin X, Ma T, Han R, Ding J, Zhang H, Han X, et al. MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)-induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018;47:79-88 pubmed publisher
    To investigate the possible molecular mechanism of low concentration plasticizer mono-n-butyl phthalate (MBP) -induced juvenile Sertoli cells (SCs) proliferation, we evaluated global alterations of miRNA and mRNA expression in rat SCs ..
  86. Pierce J, Maloy W, Salvador L, Dungan C. Recombinant expression of the antimicrobial peptide polyphemusin and its activity against the protozoan oyster pathogen Perkinsus marinus. Mol Mar Biol Biotechnol. 1997;6:248-59 pubmed
    ..coli host, we used a carboxy-terminal fusion protein cloning strategy provided by a maltose-binding protein (MBP) gene fusion system (New England Biolabs)...
  87. Camps M, Nichols A, Gillieron C, Antonsson B, Muda M, Chabert C, et al. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998;280:1262-5 pubmed
    ..Catalytic activation of MAP kinase phosphatases through substrate binding may regulate MAP kinase activation by a large number of receptor systems. ..
  88. Luzón Toro B, Rubio de la Torre E, Delgado A, Perez Tur J, Hilfiker S. Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation. Hum Mol Genet. 2007;16:2031-9 pubmed
    ..Our results suggest a molecular mechanistic explanation for how the G2019S mutation enhances the catalytic activity of LRRK2, thereby leading to pathogenicity. These findings have important implications for therapeutic strategies in PD. ..
  89. Furtado G, Marcondes M, Latkowski J, Tsai J, Wensky A, Lafaille J. Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis. J Immunol. 2008;181:4648-55 pubmed
    ..Using a model of spontaneous EAE, we demonstrated that myelin basic protein (MBP)-specific CD4(+) T cells up-regulate activation markers in the CNS-draining cervical lymph nodes at a ..
  90. Herbert M, Kuiperij H, Verbeek M. Optimisation of the quantification of glutamine synthetase and myelin basic protein in cerebrospinal fluid by a combined acidification and neutralisation protocol. J Immunol Methods. 2012;381:1-8 pubmed publisher
    ..AFBN pre-treatment protocol for CSF significantly enhances the measurement of glutamine synthetase (GS) and myelin basic protein (MBP) in CSF but does not affect detection of glial fibrillary protein (GFAP), amyloid ? 42 (A???), total ..
  91. Börnsen L, Romme Christensen J, Ratzer R, Hedegaard C, Søndergaard H, Krakauer M, et al. Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis. PLoS ONE. 2015;10:e0118830 pubmed publisher
    ..interferon-β-treated multiple sclerosis patients had decreased CD4+ T-cell reactivity to the autoantigen myelin basic protein ex vivo...
  92. Woodward N, Pakbin P, Saffari A, Shirmohammadi F, Haghani A, Sioutas C, et al. Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons. Neurobiol Aging. 2017;53:48-58 pubmed publisher
    ..Young mice showed selective changes in the hippocampal CA1 region, with neurite atrophy (-25%), decreased MBP (-50%), and increased Iba1 (+50%), with dentate gyrus relatively unaffected...