MBOAT7

Summary

Gene Symbol: MBOAT7
Description: membrane bound O-acyltransferase domain containing 7
Alias: BB1, LENG4, LPIAT, LPLAT, LRC4, MBOA7, MRT57, OACT7, hMBOA-7, lysophospholipid acyltransferase 7, 1-acylglycerophosphatidylinositol O-acyltransferase, LPLAT 7, bladder and breast carcinoma-overexpressed gene 1 protein, h-mboa-7, leukocyte receptor cluster (LRC) member 4, lyso-PI acyltransferase, lysophosphatidylinositol acyltransferase, malignant cell expression-enhanced gene/tumor progression-enhanced
Species: human
Products:     MBOAT7

Top Publications

  1. Çoban J, Doğan Ekici I, Aydın A, Betül Kalaz E, Doğru Abbasoğlu S, Uysal M. Blueberry treatment decreased D-galactose-induced oxidative stress and brain damage in rats. Metab Brain Dis. 2015;30:793-802 pubmed publisher
    ..Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with 5 % (BB1) and 10 % (BB2) BB containing chow for two months...
  2. Zhang Y, Guo T, Yang F, Mao Y, Li L, Liu C, et al. Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males. Hepatol Int. 2018;12:429-437 pubmed publisher
    ..recently confirmed that polymorphisms in PNPLA3 predispose individuals to ALD and have identified risk loci of MBOAT7 and TM6SF2 in persons of European descent...
  3. Contreras Castro L, Maldonado L, Quintana E, Raggi L, Sanchez Flores A. Draft Genome Sequence of Two Marine Plantactinospora spp. from the Gulf of California. Genome Announc. 2018;6: pubmed publisher
    i>Plantactinospora sp. strains BB1 and BC1 were isolated in 2009 from sediment samples of the Gulf of California from among almost 300 actinobacteria. Genome mining of their ?8...
  4. Ruis González M, Cañete M, Gómez Chaparro J, Abril N, Cañete R, López Barea J. Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages. J Proteomics. 2015;119:169-82 pubmed publisher
    ..b>Lysophospholipid acyltransferase 7 (MBOAT7), was detected exclusively in IUGR of all gestational ages and sampling times; seven other ..
  5. Ezzikouri S, Elfihry R, Chihab H, Elmessaoudi Idrissi M, Zaidane I, Jadid F, et al. Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients. Sci Rep. 2018;8:12247 pubmed publisher
    ..explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibrosis...
  6. Zarini S, Hankin J, Murphy R, Gijón M. Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells. Prostaglandins Other Lipid Mediat. 2014;113-115:52-61 pubmed publisher
    ..Microsomes from these cells exhibited acyltransferase activities consistent with expression of MBOAT5/LPCAT3 and MBOAT7/LPIAT1, the main arachidonoyl-CoA:lysophospholipid acyltransferases...
  7. An T, Picardal F. Desulfuromonas carbonis sp. nov., an Fe(III)-, S0- and Mn(IV)-reducing bacterium isolated from an active coalbed methane gas well. Int J Syst Evol Microbiol. 2015;65:1686-93 pubmed publisher
    ..6%). The closest cultured phylogenetic relative of strain ICBM(T) was Desulfuromonas michiganensis BB1(T) with only 95% 16S rRNA gene sequence similarity...
  8. Scott E, Anstee Q. Genetics of alcoholic liver disease and non-alcoholic steatohepatitis. Clin Med (Lond). 2018;18:s54-s59 pubmed publisher
    ..describing the best validated genetic modifiers that influence severity of these liver conditions, including variants of the genes PNPLA3, TM6SF2 and MBOAT7, which have also been implicated in lipid dysregulation.
  9. Krawczyk M, Jiménez Agüero R, Alústiza J, Emparanza J, Perugorria M, Bujanda L, et al. PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery. Surg Obes Relat Dis. 2016;12:1838-1846 pubmed publisher
    ..E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants...

More Information

Publications38

  1. Di Costanzo A, Belardinilli F, Bailetti D, Sponziello M, D Erasmo L, Polimeni L, et al. Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy. Sci Rep. 2018;8:3702 pubmed publisher
    ..by next generation sequencing in a cohort of 218 NAFLD subjects and 227 controls, where PNPLA3 rs738409 and MBOAT7 rs641738 genotypes were also obtained...
  2. Sobral F, Calhelha R, Barros L, Dueñas M, Tomás A, Santos Buelga C, et al. Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal. Molecules. 2017;22: pubmed publisher
    ..Thirty-two compounds were identified in the six BB samples, presenting BB1 and BB3 with the highest contents (6802 and 6480 µg/g extract, respectively) and the highest number of identified ..
  3. Rodriguez Cuenca S, Whyte L, Hagen R, Vidal Puig A, Fuller M. Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes. PLoS ONE. 2016;11:e0162047 pubmed publisher
    ..lateral diffusion, and is likely responsible for the transcriptional activation of Lands' cycle enzymes lpcat3 and mboat7. Of relevance these profound changes in the lipidome were not accompanied by dramatic changes in gene expression ..
  4. Anderson K, Kielkowska A, Durrant T, Juvin V, Clark J, Stephens L, et al. Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse. PLoS ONE. 2013;8:e58425 pubmed publisher
    ..They also suggest that this pathway must act in concert with other, as yet unidentified, mechanisms to achieve the enrichment observed in C38∶4 molecular species of phosphoinositides. ..
  5. Del Campo J, Gallego Durán R, Gallego P, Grande L. Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD). Int J Mol Sci. 2018;19: pubmed publisher
    ..g., pnpla3, mboat7)...
  6. Yang X, Geng C, Sun X, Yang W, Wang X, Chen J. Characteristics of particulate-bound polycyclic aromatic hydrocarbons emitted from industrial grade biomass boilers. J Environ Sci (China). 2016;40:28-34 pubmed publisher
    ..to investigate the characteristics of particulate-bound PAHs: one biomass boiler retro-fitted from an oil boiler (BB1) and one specially designed (BB2) biomass boiler. One coal-fired boiler was also selected for comparison...
  7. Stickel F, Buch S, Nischalke H, Weiss K, Gotthardt D, Fischer J, et al. Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis. Am J Gastroenterol. 2018;113:1475-1483 pubmed publisher
    ..6 superfamily member 2 (TM6SF2; rs58542926), and membrane bound O-acyltransferase domain containing 7 (MBOAT7; rs641738) are risk factors for the development of alcohol-related cirrhosis...
  8. Zainutdinov S, Tikunov A, Matveeva O, Netesov S, Kochneva G. Complete Genome Sequence of the Oncolytic Sendai virus Strain Moscow. Genome Announc. 2016;4: pubmed publisher
    ..Anecdotal evidence for the efficacy of oncolytic virotherapy exists for this strain. The RNA genome of the Moscow strain is 15,384 nucleotides in length and differs from the nearest strain, BB1, by 18 nucleotides and 11 amino acids.
  9. Donati B, Dongiovanni P, Romeo S, Meroni M, McCain M, Miele L, et al. MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals. Sci Rep. 2017;7:4492 pubmed publisher
    ..The rs641738 C?>?T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown...
  10. Sookoian S, Flichman D, Garaycoechea M, Gazzi C, Martino J, Castaño G, et al. Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease. Sci Rep. 2018;8:5097 pubmed publisher
    ..Gly17Glu) and 500 bases- downstream of MBOAT7 gene (TMC4/MBOAT7), in the genetic risk for developing NAFLD in a case-control study...
  11. Stickel F, Moreno C, Hampe J, Morgan M. The genetics of alcohol dependence and alcohol-related liver disease. J Hepatol. 2017;66:195-211 pubmed publisher
    ..of alcohol-related cirrhosis is not as well-documented but three strong candidate genes PNPLA3, TM6SF2 and MBOAT7, have been identified...
  12. Shimizu T, Shimizu S, Higashi Y, Nakamura K, Yoshimura N, Saito M. A Stress-Related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat. J Pharmacol Exp Ther. 2016;356:693-701 pubmed publisher
    ..Bombesin-like peptides and bombesin receptor types 1 and 2 (BB1 and BB2, respectively) in the brain have been implicated in the mediation/integration of stress responses...
  13. Ray S, Ali M, Mukherjee S, Chatterjee G, Banerjee M. Elimination and molecular identification of endophytic bacterial contaminants during in vitro propagation of Bambusa balcooa. World J Microbiol Biotechnol. 2017;33:31 pubmed publisher
    ..The two isolated endophytes, BB1 and BB2, were identified through 16S rDNA techniques and NCBI-BLAST algorithm with 99% sequence similarity with ..
  14. Krawczyk M, Bantel H, Rau M, Schattenberg J, Grunhage F, Pathil A, et al. Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers. J Hum Genet. 2018;63:621-626 pubmed publisher
    ..Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 rs641738 are associated with higher liver fat contents...
  15. Nakamura T, Ramos Álvarez I, Iordanskaia T, Moreno P, Mantey S, Jensen R. Molecular basis for high affinity and selectivity of peptide antagonist, Bantag-1, for the orphan BB3 receptor. Biochem Pharmacol. 2016;115:64-76 pubmed publisher
    ..Bombesin-family because of high homology to gastrin-releasing peptide (BB2 receptor)/neuromedin-B receptors (BB1 receptor)...
  16. Fukunaga Johnson N, Lee S, Liebert M, Grossman H. Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma. Anticancer Res. 1996;16:1085-90 pubmed
    ..A 1897 bp cDNA clone was isolated following expression screening with the AN43 antibody and named BB1. Following DNA sequencing, the BB1 cDNA clone was determined to have no homology to any known gene when screened ..
  17. Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009;50 Suppl:S46-51 pubmed publisher
    ..These discoveries have prompted a robust surge of research in this field. In this review, we focus on the cloning and characterization of lysophospholipid acyltransferases (LPLATs), which contribute to membrane asymmetry and diversity. ..
  18. Hirata Y, Yamamori N, Kono N, Lee H, Inoue T, Arai H. Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein. Genes Cells. 2013;18:397-409 pubmed publisher
    b>Lysophosphatidylinositol acyltransferase 1 (LPIAT1), also known as MBOAT7, is a phospholipid acyltransferase that selectively incorporates arachidonic acid (AA) into the sn-2 position of phosphatidylinositol (PI)...
  19. Eslam M, Valenti L, Romeo S. Genetics and epigenetics of NAFLD and NASH: Clinical impact. J Hepatol. 2018;68:268-279 pubmed publisher
    ..Variants with moderate effect size in TM6SF2, MBOAT7 and GCKR have also been shown to have a significant contribution...
  20. Gijón M, Riekhof W, Zarini S, Murphy R, Voelker D. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J Biol Chem. 2008;283:30235-45 pubmed publisher
    ..MBOAT7 is a lysophosphatidylinositol acyltransferase with remarkable specificity for arachidonoyl-CoA...
  21. Thabet K, Chan H, Petta S, Mangia A, Berg T, Boonstra A, et al. The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B. Hepatology. 2017;65:1840-1850 pubmed publisher
    ..Recently, the rs641738 membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) polymorphism was demonstrated to influence histological liver damage in alcoholic liver disease, nonalcoholic ..
  22. Koo B, Joo S, Kim D, Bae J, Park J, Kim J, et al. Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2017;: pubmed publisher
    We investigated the effects of PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7-TMC4 rs641738 variants on metabolic phenotypes and their combined effects on the histological severity of non-alcoholic fatty liver disease (NAFLD).
  23. Lee H, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, et al. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell. 2008;19:1174-84 pubmed
    ..LysoPI acyltransferase (LPIAT) is thought to catalyze formation of AA-containing PI; however, the gene that encodes this enzyme has not yet been ..
  24. Mancina R, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, et al. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. Gastroenterology. 2016;150:1219-1230.e6 pubmed publisher
    ..rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol ..
  25. Krawczyk M, Rau M, Schattenberg J, Bantel H, Pathil A, Demir M, et al. Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study. J Lipid Res. 2017;58:247-255 pubmed publisher
    The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD)...
  26. Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke H, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet. 2015;47:1443-8 pubmed publisher
    ..We identified variants in the MBOAT7 (P = 1.03 × 10(-9)) and TM6SF2 (P = 7...
  27. Johansen A, Rosti R, Musaev D, Sticca E, Harripaul R, Zaki M, et al. Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features. Am J Hum Genet. 2016;99:912-916 pubmed publisher
    ..six consanguineous families harboring homozygous inactivating variants in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1). Subjects presented with ID frequently accompanied by epilepsy and autistic features...
  28. Viitasalo A, Eloranta A, Atalay M, Romeo S, Pihlajamaki J, Lakka T. Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study. Pediatr Res. 2016;80:651-655 pubmed publisher
    ..children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults...
  29. Wende H, Volz A, Ziegler A. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Immunogenetics. 2000;51:703-13 pubmed
    ..Together with the gene for the ribosomal protein S9 (RPS9), which had previously been assigned to 19q13.4, the total number of LRC genes is now 44. Of these, 29 belong to the Ig superfamily. ..