MBNL1

Summary

Gene Symbol: MBNL1
Description: muscleblind like splicing regulator 1
Alias: EXP, MBNL, muscleblind-like protein 1, muscleblind-like, triplet-expansion RNA-binding protein
Species: human
Products:     MBNL1

Top Publications

  1. Fardaei M, Larkin K, Brook J, Hamshere M. In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts. Nucleic Acids Res. 2001;29:2766-71 pubmed
    ..We have investigated the role of three RNA-binding proteins, CUG-BP, hnRNP C and MBNL, as possible sequestered factors...
  2. Dansithong W, Paul S, Comai L, Reddy S. MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005;280:5773-80 pubmed
    In myotonic dystrophy 1 (DM1), aggregation of the mutant DMPK RNA into RNA-protein complexes containing MBNL1 and MBNL2 has been linked to aberrant splicing of the insulin receptor (IR) RNA...
  3. Onishi H, Kino Y, Morita T, Futai E, Sasagawa N, Ishiura S. MBNL1 associates with YB-1 in cytoplasmic stress granules. J Neurosci Res. 2008;86:1994-2002 pubmed publisher
    ..In this study, we attempted to find the binding proteins of MBNL1 in order to elucidate its physiological function...
  4. Cass D, Hotchko R, Barber P, Jones K, Gates D, Berglund J. The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements. BMC Mol Biol. 2011;12:20 pubmed publisher
    Muscleblind-like 1 (MBNL1) is an alternative splicing factor containing four CCCH Zinc fingers (ZnFs). The sequestration of MBNL1 by expanded CUG and CCUG repeats is a major component in causing myotonic dystrophy...
  5. Venables J, Lapasset L, Gadea G, Fort P, Klinck R, Irimia M, et al. MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun. 2013;4:2480 pubmed publisher
    ..alternative splicing changes involved in late mesoderm differentiation and controlled by key splicing regulators MBNL1 and RBFOX2...
  6. Teplova M, Patel D. Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol. 2008;15:1343-51 pubmed publisher
    ..The crystal structure of MBNL1 ZnF3/4 bound to r(CGCUGU) establishes that both ZnF3 and ZnF4 target GC steps, with site-specific recognition ..
  7. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster N. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010;285:25426-37 pubmed publisher
    ..We subsequently used RNA affinity chromatography to identify Mbnl1 as a splicing factor that recognizes this enhancer...
  8. Fu Y, Ramisetty S, Hussain N, Baranger A. MBNL1-RNA recognition: contributions of MBNL1 sequence and RNA conformation. Chembiochem. 2012;13:112-9 pubmed publisher
    ..It has been suggested that as a result of binding to the repeating RNA sequences, MBNL1 is abnormally expressed and translocated, which leads to many of the misregulated events in myotonic dystrophy...
  9. Purcell J, Oddo J, Wang E, Berglund J. Combinatorial mutagenesis of MBNL1 zinc fingers elucidates distinct classes of regulatory events. Mol Cell Biol. 2012;32:4155-67 pubmed
    The RNA binding protein and alternative splicing factor Muscleblind-like 1 (MBNL1) has been a topic of intense study due to its role in myotonic dystrophy (DM) pathogenesis...

More Information

Publications107 found, 100 shown here

  1. Miller J, Urbinati C, Teng Umnuay P, Stenberg M, Byrne B, Thornton C, et al. Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO J. 2000;19:4439-48 pubmed
    ..Here, we identify the triplet repeat expansion (EXP) RNA-binding proteins as candidate sequestered factors...
  2. Kino Y, Mori D, Oma Y, Takeshita Y, Sasagawa N, Ishiura S. Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats. Hum Mol Genet. 2004;13:495-507 pubmed
    ..Here, it was attempted to compare the RNA-binding properties of three proteins, CUG-BP, MBNL1/EXP and PKR, which have previously been suggested to interact with CUG repeats...
  3. Ho T, Charlet B N, Poulos M, Singh G, Swanson M, Cooper T. Muscleblind proteins regulate alternative splicing. EMBO J. 2004;23:3103-12 pubmed
    Although the muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), a specific function for these proteins has not been reported...
  4. Cardani R, Mancinelli E, Rotondo G, Sansone V, Meola G. Muscleblind-like protein 1 nuclear sequestration is a molecular pathology marker of DM1 and DM2. Eur J Histochem. 2006;50:177-82 pubmed
    ..To determine whether MBNL1 nuclear sequestration is a feature of DM pathologies, we have examined the in vivo distribution of MBNL1 in muscle ..
  5. Smith K, Byron M, Johnson C, Xing Y, Lawrence J. Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains. J Cell Biol. 2007;178:951-64 pubmed
    ..Despite their exclusion from these compartments, mutant transcripts are spliced. MBNL1 (muscleblind-like protein 1) is an alternative splicing factor that becomes highly concentrated with mutant RNA ..
  6. Warf M, Berglund J. MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. RNA. 2007;13:2238-51 pubmed
    ..It is hypothesized that the RNA splicing factor muscleblind-like (MBNL) is sequestered to the expanded CUG or CCUG RNAs...
  7. Tran H, Gourrier N, Lemercier Neuillet C, Dhaenens C, Vautrin A, Fernandez Gomez F, et al. Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms. J Biol Chem. 2011;286:16435-46 pubmed publisher
    Muscleblind-like-1 (MBNL1) is a splicing regulatory factor controlling the fetal-to-adult alternative splicing transitions during vertebrate muscle development...
  8. Fugier C, Klein A, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, et al. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy. Nat Med. 2011;17:720-5 pubmed publisher
    ..These mutant RNAs sequester the splicing regulator Muscleblind-like-1 (MBNL1), resulting in specific misregulation of the alternative splicing of other pre-mRNAs...
  9. Gates D, Coonrod L, Berglund J. Autoregulated splicing of muscleblind-like 1 (MBNL1) Pre-mRNA. J Biol Chem. 2011;286:34224-33 pubmed publisher
    Muscleblind-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic dystrophy. In myotonic dystrophy, the lack of properly localized MBNL1 leads to missplicing of many pre-mRNAs...
  10. Carpentier C, Ghanem D, Fernandez Gomez F, Jumeau F, Philippe J, Freyermuth F, et al. Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2. Biochim Biophys Acta. 2014;1842:654-64 pubmed publisher
    ..We therefore used new Tau minigenes that we developed for this purpose to determine how MBNL1 and MBNL2 interact to regulate Tau exon 2 splicing...
  11. Mankodi A, Urbinati C, Yuan Q, Moxley R, Sansone V, Krym M, et al. Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. Hum Mol Genet. 2001;10:2165-70 pubmed
    ..These results support the idea that nuclear accumulation of mutant RNA is pathogenic in DM1, suggest that a similar disease process occurs in DM2, and point to a role for muscleblind in the pathogenesis of both disorders. ..
  12. Fardaei M, Rogers M, Thorpe H, Larkin K, Hamshere M, Harper P, et al. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells. Hum Mol Genet. 2002;11:805-14 pubmed
    ..gene producing multiple proteins through alternative splicing, there are in fact three different muscleblind genes, MBNL, MBLL and MBXL, which map to chromosomes 3, 13 and X, respectively, and which show extensive alternative splicing...
  13. Lin X, Miller J, Mankodi A, Kanadia R, Yuan Y, Moxley R, et al. Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet. 2006;15:2087-97 pubmed
    ..The repeat-bearing transcripts accumulate in nuclear foci, together with proteins in the muscleblind family, MBNL1 and MBNL2...
  14. Paul S, Dansithong W, Kim D, Rossi J, Webster N, Comai L, et al. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006;25:4271-83 pubmed
    ..Elevated levels of MBNL1 show RNA-independent interaction with hnRNP H and dampen the inhibitory activity of increased hnRNP H levels on IR ..
  15. Vicente Crespo M, Pascual M, Fernandez Costa J, Garcia Lopez A, Monferrer L, Miranda M, et al. Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS ONE. 2008;3:e1613 pubmed publisher
    Muscleblind-like proteins (MBNL) have been involved in a developmental switch in the use of defined cassette exons...
  16. Oddo J, Saxena T, McConnell O, Berglund J, Wang E. Conservation of context-dependent splicing activity in distant Muscleblind homologs. Nucleic Acids Res. 2016;44:8352-62 pubmed publisher
    ..While regulation of specific target exons by MBL/MBNL has not been broadly conserved across these species, genes enriched for MBL/MBNL binding sites in their introns may ..
  17. Puscheck E, Bolnick A, Awonuga A, Yang Y, Abdulhasan M, Li Q, et al. Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART. J Assist Reprod Genet. 2018;: pubmed publisher
    ..Stress markers, such as checkpoint proteins like TRP53 (aka p53) (Ganeshan et al., Exp Cell Res 358:227-233, 2017); Ganeshan et al...
  18. Du J, Aleff R, Soragni E, Kalari K, Nie J, Tang X, et al. RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy. J Biol Chem. 2015;290:5979-90 pubmed publisher
    ..Similar to myotonic dystrophy type 1, the poly(CUG)n RNA co-localizes with and sequesters the mRNA-splicing factor MBNL1, leading to missplicing of essential MBNL1-regulated mRNAs...
  19. Dastidar S, Ardui S, Singh K, Majumdar D, Nair N, Fu Y, et al. Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells. Nucleic Acids Res. 2018;46:8275-8298 pubmed publisher
    ..Consequently, the normal intracellular localization of the muscleblind-like splicing regulator 1 (MBNL1) was restored, resulting in the normalization of splicing pattern of SERCA1...
  20. Chou C, Chang P, Wei Y, Lee K. Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Control wild-type (Mbnl1+/+; Mbnl2+/+ ) and DM mutant (Mbnl1-/-; Mbnl2+/- ) mice ..
  21. Yenigun V, Sirito M, Amcheslavky A, Czernuszewicz T, Colonques Bellmunt J, Garcia Alcover I, et al. (CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis. Dis Model Mech. 2017;10:993-1003 pubmed publisher
    ..Mis-splicing could be rescued by co-expression of human MBNL1, but not by CUGBP1 (CELF1) complementation...
  22. Liu X, Liu W, Sun Y, Xia C, Elmerich C, Xie Z. A cheZ-Like Gene in Azorhizobium caulinodans Is a Key Gene in the Control of Chemotaxis and Colonization of the Host Plant. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..In particular, it was observed that the expression of several exp genes, involved in EPS synthesis, was upregulated in the cheZ mutant compared to that in the wild type, ..
  23. Xia G, Gao Y, Jin S, Subramony S, Terada N, Ranum L, et al. Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells. Stem Cells. 2015;33:1829-38 pubmed publisher
    ..Alternative splicing of microtubule-associated protein tau (MAPT) and muscleblind-like (MBNL) proteins were analyzed to further monitor the phenotype reversal after genome modification...
  24. Chapman K, Rosenbaum D. Bimanual comfort depends on how extreme either hand's posture is, not on which hand is in the more extreme posture. Psychol Res. 2017;81:332-341 pubmed publisher
    ..known features of performance, a recent study of object transfer behavior (Coelho, Studenka, & Rosenbaum, J Exp Psychol Human Percept Perform, 40:718-730, 2014) showed that people place greater emphasis on using the hand that ..
  25. Scheil J. Effects of absolute and relative practice on n-2 repetition costs. Acta Psychol (Amst). 2016;164:65-9 pubmed publisher
    ..designed in which for one of the three tasks, aspects of the task set changed during the course of the experiment (Exp. I: Stimulus-response mapping, Exp. II: Cue-task mapping)...
  26. Wang H, Ryser E. Quantitative transfer of Salmonella Typhimurium LT2 during mechanical slicing of tomatoes as impacted by multiple processing variables. Int J Food Microbiol. 2016;234:76-82 pubmed publisher
    ..The data were fitted to a two-parameter exponential decay model (Y=Aâ‹…exp(BX)) with the percentage of Salmonella transferred to 20 uninoculated tomatoes then calculated...
  27. Cavazos J, Noyes E, O Toole A. Learning context and the other-race effect: Strategies for improving face recognition. Vision Res. 2018;: pubmed publisher
    ..The distributed presentation yielded better recognition when people learned from single repeated images (Exp. 1), but not when they learned from multiple variable images (Exp. 2)...
  28. Oeberst A, Lindner I. Unannounced memory tests are not necessarily unexpected by participants: test expectation and its consequences in the repeated test paradigm. Cogn Process. 2015;16:269-78 pubmed publisher
    ..Following identical instructions, test expectancy was shown to be a function of the experimental procedure (Exp. 1)...
  29. Goodwin M, Mohan A, Batra R, Lee K, Charizanis K, Fernández Gómez F, et al. MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain. Cell Rep. 2015;12:1159-68 pubmed publisher
    ..Similar RNA processing defects were detected in Mbnl compound-knockout mice, highlighted by dysregulation of Mapt splicing and fetal tau isoform expression in adults...
  30. Weiss S, Simeonova D, Kimmel M, Battle C, Maki P, Flynn H. Anxiety and physical health problems increase the odds of women having more severe symptoms of depression. Arch Womens Ment Health. 2016;19:491-9 pubmed publisher
    ..indicate that a woman's level of anxiety was the strongest predictor of her likelihood of having severe depression (Exp(B) = 1.33, p = .000), including thoughts of death or suicide...
  31. Thu O, Spigset O, Nilsen O, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016;72:295-300 pubmed publisher
    ..A statistically significant 21% decrease in the EXP-3174/losartan ratio was found after pretreatment with R. rosea (p = 0...
  32. Morón M, Prada Gracia D, Falo F. Macro and nano scale modelling of water-water interactions at ambient and low temperature: relaxation and residence times. Phys Chem Chem Phys. 2016;18:9377-87 pubmed publisher
    ..A stretched exponential function exp[-(t/τ)(β)] has been found to properly describe the relaxation of residence times calculated at different ..
  33. Dalkin S, Lhussier M, Philipson P, Jones D, Cunningham W. Reducing inequalities in care for patients with non-malignant diseases: Insights from a realist evaluation of an integrated palliative care pathway. Palliat Med. 2016;30:690-7 pubmed publisher
    ..001) in registrations between the malignant and non-malignant groups in 2011, with an odds ratio of 0.09 (=exp(-2.4266)), indicating that patients in the non-malignant group are around 11 times (1/0...
  34. Gesser Edelsburg A, Walter N, Shir Raz Y, Sassoni Bar Lev O, Rosenblat S. The behind-the-scenes activity of parental decision-making discourse regarding childhood vaccination. Am J Infect Control. 2017;45:267-271 pubmed publisher
    ..4 times more likely to conduct intrafamily discussion regarding vaccination compared with provaccination parents (Exp[B]?=?4.26)...
  35. Naefgen C, Dambacher M, Janczyk M. Why free choices take longer than forced choices: evidence from response threshold manipulations. Psychol Res. 2018;82:1039-1052 pubmed publisher
    ..these accounts empirically discriminable by manipulating decision thresholds via the frequency of catch trials (Exp. 1) or via inducing time pressure (Exp. 2 and 3)...
  36. Bjornson C, Chan P, Li A, Paes B, Lanctot K, Mitchell I. Palivizumab prophylaxis for respiratory syncytial virus in infants with cystic fibrosis: is there a need?. Eur J Clin Microbiol Infect Dis. 2018;37:1113-1118 pubmed publisher
    ..versus UPVZ, adjusting for gestational age, birth weight, birth during RSV peak months, and presence of siblings (Exp(B)?=?0.23 [0.11-0.49], p?<?0.0005)...
  37. Gerken L, Knight S. Infants generalize from just (the right) four words. Cognition. 2015;143:187-92 pubmed publisher
    ..a subset of their input at one time, does generalization change when that subset supports multiple generalizations? Exp. 1 asked whether 11-month-olds generalize the relation between two consonants in a word when just four input words ..
  38. Djahaniani H, Fatemi F, Ektefa F, Mohtat B, Notash B. Green approach to stereoselective synthesis of benzo[d]chromeno[3,4- h]oxathiazonine derivatives via MCRs in water: a combined experimental and DFT study. Comb Chem High Throughput Screen. 2015;18:990-9 pubmed
    ..A comparison between the experimental (Exp.) and calculated (Cal...
  39. Campellone T, Elis O, Mote J, Sanchez A, Kring A. Negative symptoms in psychometrically defined schizotypy: The role of depressive symptoms. Psychiatry Res. 2016;240:181-186 pubmed publisher
    ..have negative symptoms, including diminished experience of motivation/pleasure (MAP) and emotional expressivity (EXP)...
  40. Maia N, Loureiro J, Oliveira B, Marques I, Santos R, Jorge P, et al. Contraction of fully expanded FMR1 alleles to the normal range: predisposing haplotype or rare events?. J Hum Genet. 2017;62:269-275 pubmed publisher
    ..alleles from this SNP background also shared phylogenetically close STR haplotypes, although a single (CGG)exp>(CGG)24 contraction or the loss of AGG interruptions may explain their origin...
  41. Hughes J, Schnur T. Facilitation and interference in naming: A consequence of the same learning process?. Cognition. 2017;165:61-72 pubmed publisher
    ..tasks and is caused by learning, as measured by two repetition priming tasks (picture-picture repetition priming, Exp. 1; definition-picture repetition priming, Exp. 2, e.g., Wheeldon & Monsell, 1992)...
  42. Röttger E, Haider H, Zhao F, Gaschler R. Implicit sequence learning despite multitasking: the role of across-task predictability. Psychol Res. 2017;: pubmed publisher
    ..and Heuer in Psychol Res 60(1-2):53-71, 1997)-or with (b) parallel response selection (Schumacher and Schwarb in J Exp Psychol Gen 138(2):270-290, 2009)...
  43. Khan E, Tawani A, Mishra S, Verma A, Upadhyay A, Kumar M, et al. Myricetin reduces toxic level of CAG repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs). ACS Chem Biol. 2017;: pubmed publisher
    ..CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1) and thus both of these elicits the pathogenesis of HD...
  44. Batterham A, Vanderburgh P, Mahar M, Jackson A. Modeling the influence of body size on V(O2) peak: effects of model choice and body composition. J Appl Physiol (1985). 1999;87:1317-25 pubmed
    ..The simple model was described by V(O2) peak = M(b) (or FFM(b)) exp(c SR-PA) exp(a + d age) epsilon (where M is body mass in kg; FFM is fat-free mass in kg; SR-PA is self-reported ..
  45. Chen L, Zhang M, Ai F, Xie W, Meng X. Crossmodal synesthetic congruency improves visual timing in dyslexic children. Res Dev Disabil. 2016;55:14-26 pubmed publisher
    ..The multisensory facilitation for timing performance was correlated with reading ability (Exp.1)...
  46. Cheng C, Zhang X, Xia M, Liu Z, Wei H, Deng Z, et al. Effect of oregano essential oil and benzoic acid supplementation to a low-protein diet on meat quality, fatty acid composition, and lipid stability of longissimus thoracis muscle in pigs. Lipids Health Dis. 2017;16:164 pubmed publisher
    ..In Exp. 1, 21 barrows were housed in metabolism cages and randomly allotted to 1 of 3 diets...
  47. Nakamura T, Ohsawa Yoshida N, Zhao Y, Koebis M, Oana K, Mitsuhashi H, et al. Splicing of human chloride channel 1. Biochem Biophys Rep. 2016;5:63-69 pubmed publisher
    ..as have investigations into the activation and suppression of normal splicing variant expression by MBNL1-3 and CELF3-6, respectively...
  48. Ong N, Hodges N. Balancing Our Perceptions of the Efficacy of Success-Based Feedback Manipulations on Motor Learning. J Mot Behav. 2017;:1-17 pubmed publisher
    We report two experiments evaluating the impact of success-related feedback on learning of a balance task. In Exp. 1, we studied the influence of lax and conservative outcome feedback, as well as large vs...
  49. Wang Y, Wright P, Heigenhauser G, Wood C. Lactate transport by rainbow trout white muscle: kinetic characteristics and sensitivity to inhibitors. Am J Physiol. 1997;272:R1577-87 pubmed
    ..b>Exp. Biol. 105: 895-401, 1983).
  50. Geller J, Still M, Morris A. Eyes wide open: Pupil size as a proxy for inhibition in the masked-priming paradigm. Mem Cognit. 2016;44:554-64 pubmed publisher
    ..Sears, & Lupker, Journal of Experimental Psychology: Human Perception and Performance, 34, 1236-1260, 2008, Exp. 1)...
  51. Cioffi G, Viapiana O, Ognibeni F, Fracassi E, Giollo A, Adami S, et al. Prevalence and Factors Associated with Subclinical Left Ventricular Systolic Dysfunction Evaluated by Mid-Wall Mechanics in Rheumatoid Arthritis. Echocardiography. 2016;33:1290-9 pubmed publisher
    ..Multiple logistic regression analysis revealed that RA was independently associated with impaired sc-MS (Exp β 2.01 [CI 1.12-3.80], P = 0.02) together with increased LV mass and concentric geometry...
  52. Cho D, Wi J, Suh H. Two new species of the deep-sea genus Parameiropsis (Copepoda: Harpacticoida) from the eastern central Pacific. Zootaxa. 2016;4132:521-39 pubmed publisher
    ..magnus by a higher length-to-width ratio of the caudal ramus (2.5:1 and 1:1 respectively), the setal number on the exp-3 of P1, and the exp and benp of P5 are separated in P. kodosensis, while they are fused in P. magnus...
  53. Norman R, Wills A. An Investigation into the Relationship between Owner Knowledge, Diet, and Dental Disease in Guinea Pigs (Cavia porcellus). Animals (Basel). 2016;6: pubmed
    ..6% had signs consistent with dental disease. The specific clinical signs of having difficulty eating (Exp(B) = 33.927, Nagelkerke R ² = 0.301, p < 0.05) and producing fewer or smaller faecal droppings (Exp(B) = 13...
  54. Plunkett A, Haley C, McCoart A, Beltran T, Highland K, Berry Cabán C, et al. A Preliminary Examination of the Comparative Efficacy of Intravenous vs Oral Acetaminophen in the Treatment of Perioperative Pain. Pain Med. 2016;: pubmed publisher
    ..24, exp(b) = 1.28, p = 0.68)...
  55. Powell D, McMinn D, Allan J. Does real time variability in inhibitory control drive snacking behavior? An intensive longitudinal study. Health Psychol. 2017;36:356-364 pubmed publisher
    ..67% higher, Exp (γ) = 1.26, p = .002, 95% confidence interval (CI) [1.06, 1.49]...
  56. Bertels J, Kolinsky R. Disentangling fast and slow attentional influences of negative and taboo spoken words in the emotional Stroop paradigm. Cogn Emot. 2016;30:1137-48 pubmed publisher
    ..The aim of the present study was to investigate fast and slow effects of negative (Exp. 1) and taboo (Exp. 2) spoken words...
  57. Meyer T, Chavanon M, Herrrmann Lingen C, Roggenthien M, Nolte K, Pieske B, et al. Elevated Plasma C-Terminal Endothelin-1 Precursor Fragment Concentrations Are Associated with Less Anxiety in Patients with Cardiovascular Risk Factors. Results from the Observational DIAST-CHF Study. PLoS ONE. 2015;10:e0136739 pubmed publisher
    ..systolic blood pressure, and diameters of left atrium and ventricle, plasma CT-proET-1 was again linked to anxiety (Exp(β) = 0.247, 95%-confidence interval [95%-CI] = 0.067-0.914, p = 0.036)...
  58. Goller F, Ditye T, Ansorge U. The contribution of color to attention capture effects during search for onset targets. Atten Percept Psychophys. 2016;78:789-807 pubmed publisher
    ..2a, 2b, 3a, 3b, and the white-target conditions of Exp. 5)...
  59. Macedo N, Cheeran M, Rovira A, Holtcamp A, Torremorell M. Effect of enrofloxacin on Haemophilus parasuis infection, disease and immune response. Vet Microbiol. 2017;199:91-99 pubmed publisher
    ..parasuis strain. Pigs that were only inoculated with the agent (EXP group) and pigs that were treated with enrofloxacin and then inoculated (ABT/EXP group) developed signs of disease ..
  60. Jog S, Paul S, Dansithong W, Tring S, Comai L, Reddy S. RNA splicing is responsive to MBNL1 dose. PLoS ONE. 2012;7:e48825 pubmed publisher
    ..CUG repeat RNAs form hairpin secondary structures that bind and aberrantly sequester the RNA splice regulator, MBNL1. RNA splice defects resulting as a consequence of MBNL1 depletion have been shown to play a key role in the ..
  61. Graw J. From eyeless to neurological diseases. Exp Eye Res. 2017;156:5-9 pubmed publisher
    ..Even if this hypothesis was rejected by David Beebe's last paper (Bei et al., Exp. Eye Res...
  62. Finucane K, Singh B. Role of bronchodilation and pattern of breathing in increasing expiratory flow during progressive hypercapnia in chronic obstructive pulmonary disease. J Appl Physiol (1985). 2017;:jap.00752.2016 pubmed publisher
    ..relaxes airway smooth muscle; in-vivo it increases respiratory effort, tidal expiratory flows (V'exp), and, by decreasing inspiratory duration (Ti), increases elastic recoil pressure (Pel) via lung visco-..
  63. Tang R, Qi Q, Wu R, Zhou X, Wu D, Zhou H, et al. The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment. Carcinogenesis. 2015;36:867-75 pubmed publisher
    ..001), and this C allele prevalence is related to low level of miR-1307 expression. A RNA-binding protein MBNL1 binds with a 'UGCUGC' motif in the terminal-loop of the C-allelic pre-miR-1307 and blocks Dicer processing, ..
  64. Schäfer S, Wesslein A, Spence C, Wentura D, Frings C. Self-prioritization in vision, audition, and touch. Exp Brain Res. 2016;234:2141-50 pubmed publisher
    To investigate self-prioritization independently of stimulus familiarity, Sui et al. (J Exp Psychol Hum Percept Perform 38:1105-1117, 2012. doi: 10...
  65. Powers J, Lienlaf M, Perez Villarroel P, Deng S, Knox T, Villagra A, et al. Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignancies. Methods Mol Biol. 2016;1436:129-45 pubmed publisher
    ..Int J Cancer 112: 26-32, 2004; Jin et al. Int J Clin Exp Pathol 7: 5872-5879, 2014), suggesting that loss of HDAC10 expression might confer a survival advantage to ..
  66. Ivanova O, Dobryakova Y, Salozhin S, Aniol V, Onufriev M, Gulyaeva N, et al. Lentiviral Modulation of Wnt/?-Catenin Signaling Affects In Vivo LTP. Cell Mol Neurobiol. 2017;37:1227-1241 pubmed publisher
    ..in J Biol Chem 281:11910-11916, 2006; Vargas et al. in J Neurosci 34:2191-2202, 2014, Vargas et al. in Exp Neurol 264:14-25, 2015)...
  67. Asanowicz D, Kruse L, Åšmigasiewicz K, Verleger R. Lateralization of spatial rather than temporal attention underlies the left hemifield advantage in rapid serial visual presentation. Brain Cogn. 2017;118:54-62 pubmed publisher
    ..Participants performed two tasks: the "standard" bilateral RSVP task (Exp.1) and its unilateral variant (Exp.1 & 2)...
  68. Shi C, Zhang Y, Yin Y, Wang C, Lu Z, Wang F, et al. Amino acid and phosphorus digestibility of fermented corn-soybean meal mixed feed with Bacillus subtilis and Enterococcus faecium fed to pigs. J Anim Sci. 2017;95:3996-4004 pubmed publisher
    ..Two animal experiments were conducted to evaluate the digestibility of CP and P in FMF when fed to pigs. In Exp. 1, 6 barrows (15.20 ± 1...
  69. Toth T, Berg E, Daun S. Modeling search movements of an insect's front leg. Physiol Rep. 2017;5: pubmed publisher
    ..In the simulations with the model, we attempted to mimic the experimental results by Berg et al. (J. Exp. Biol...
  70. Qing J, Chen A, Zhao N. A new scaling for the rotational diffusion of molecular probes in polymer solutions. Phys Chem Chem Phys. 2017;19:32687-32697 pubmed publisher
    ..Correspondingly, we obtain a novel scaling form for the rotational retardation factor, following Rrot = exp[a(rh/?)b] with rather robust parameters of a ? 0.51 and b ? 0.56...
  71. Vakati V, Lee W. Five new species of the genus <i>Nannopus</i> (Copepoda: Harpacticoida: Nannopodidae) from intertidal mudflats of the Korean West Coast (Yellow Sea). Zootaxa. 2017;4360:1-66 pubmed publisher
    ..Nannopus minutus sp. nov. and N. dimorphicus sp. nov. belong to a group of species defined by seven elements on P4 exp-3, and these two species are unique by the pinnate caudal seta III...
  72. Hoover A, Elzein Y, Harris L. Left-handers show no self-advantage in detecting a delay in visual feedback concerning an active movement. Exp Brain Res. 2016;234:1915-1923 pubmed publisher
    ..in a natural perspective compared to when it is seen as if viewing another person's hand (Hoover and Harris in Exp Brain Res 233:1053-1060, 2012. doi: 10.1007/s00221-014-4181-9 ; Exp Brain Res 222:389-397, 2015a. doi: 10...
  73. Locke S, Landy M. Temporal causal inference with stochastic audiovisual sequences. PLoS ONE. 2017;12:e0183776 pubmed publisher
    ..We conducted a rate-discrimination task (Exp 1), using slower, more random sequences than previous studies, and a separate causal-judgement task (Exp 2)...
  74. Herráiz Adillo Á, Cavero Redondo I, Álvarez Bueno C, Martínez Vizcaíno V, Pozuelo Carrascosa D, Notario Pacheco B. Factors affecting the validity of the oscillometric Ankle Brachial Index to detect peripheral arterial disease. Int Angiol. 2017;36:536-544 pubmed publisher
    ..6% and 97.4%, respectively, and covariates explaining the rate of false negatives in PAD population were setting (Exp(?)=17.21, P=0.009) and tobacco (packs/year) (Exp(?)=1.049, P=0.002)...
  75. Strori D, Zaar J, Cooke M, Mattys S. Sound specificity effects in spoken word recognition: The effect of integrality between words and sounds. Atten Percept Psychophys. 2018;80:222-241 pubmed publisher
    ..Namely, the classic voice-specificity effect (Exp. 1a) was compared with a condition in which the intensity envelope of a background sound was modulated along the ..
  76. ALCANTARA C, Patel S, Carnethon M, Castañeda S, Isasi C, Davis S, et al. Stress and Sleep: Results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study. SSM Popul Health. 2017;3:713-721 pubmed publisher
    ..In the adjusted aggregate model, only chronic moderate/severe stress was associated with insomnia symptoms (exp(b)= 1.07 for each additional stressor, 95% CI= 1.05, 1.09). Both acculturation stress (exp(b)= 1...
  77. Grazul Bilska A, Thammasiri J, Kraisoon A, Reyaz A, Bass C, Kaminski S, et al. Expression of progesterone receptor protein in the ovine uterus during the estrous cycle: Effects of nutrition, arginine and FSH. Theriogenology. 2018;108:7-15 pubmed publisher
    ..In exp. 1, ewes from each diet were randomly assigned to one of two treatments, Arg or Sal administration three times ..
  78. Paul S, Dansithong W, Jog S, Holt I, Mittal S, Brook J, et al. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011;286:38427-38 pubmed publisher
    To understand the role of the splice regulator muscleblind 1 (MBNL1) in the development of RNA splice defects in myotonic dystrophy I (DM1), we purified RNA-independent MBNL1 complexes from normal human myoblasts and examined the ..
  79. Waddell M, Amazeen E. Evaluating the contributions of muscle activity and joint kinematics to weight perception across multiple joints. Exp Brain Res. 2017;235:2437-2448 pubmed publisher
    ..J Exp Psychol Hum Percept Perform 42:363-374, 2016)...
  80. Thomaschke R, Miall R, Rueß M, Mehta P, Hopkins B. Visuomotor and motorvisual priming with different types of set-level congruency: evidence in support of ideomotor theory, and the planning and control model (PCM). Psychol Res. 2018;82:1073-1090 pubmed publisher
    ..We tested this hypothesis by employing in a motorvisual (Exp. 1) and in a visuomotor (Exp...
  81. Feenstra B, Geller F, Krogh C, Hollegaard M, Gørtz S, Boyd H, et al. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. Nat Genet. 2012;44:334-7 pubmed publisher
    ..61; P = 1.5 × 10(-17)) at 3p25.1, is located 150 kb upstream of MBNL1, which encodes a factor that regulates splicing transitions occurring shortly after birth...
  82. Roberts J, Blinch J, Elliott D, Chua R, Lyons J, Welsh T. The violation of Fitts' Law: an examination of displacement biases and corrective submovements. Exp Brain Res. 2016;234:2151-63 pubmed publisher
    ..in Exp Brain Res 223:505-515, 2012)...
  83. Cadenas J, Leiva Revilla J, Vieira L, Apolloni L, Aguiar F, Alves B, et al. Caprine ovarian follicle requirements differ between preantral and early antral stages after IVC in medium supplemented with GH and VEGF alone or in combination. Theriogenology. 2017;87:321-332 pubmed publisher
    ..physiological concentration (10 ng/mL) on the IVC of two different follicular categories: preantral (experiment 1; Exp.1) and early antral (experiment 2; Exp.2). Isolated follicles were individually cultured for 24 (Exp...
  84. Anil Kumar K, Babu S, Reddy Prasad V, Damodaraiah S, Ratnakaram Y. Spectral investigations on Eu3+ ,Sm3+ -doped and Sm3+ /Eu3+ co-doped potassium-fluoro-phosphate glass emitting intense orange-red for lighting applications. Luminescence. 2017;32:1456-1465 pubmed publisher
    ..fluorescence branching ratios (?), stimulated emission cross-sections (?e ) and lifetimes (?exp ) for certain transitions or levels were evaluated...
  85. Konieczny P, Selma Soriano E, Rapisarda A, Fernandez Costa J, Perez Alonso M, Artero R. Myotonic dystrophy: candidate small molecule therapeutics. Drug Discov Today. 2017;22:1740-1748 pubmed publisher
    ..formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions...
  86. Lin Y, Li Y, Ma J. Aberrant Promoter Methylation of Protocadherin8 (PCDH8) in Serum is a Potential Prognostic Marker for Low Gleason Score Prostate Cancer. Med Sci Monit. 2017;23:4895-4900 pubmed
    ..for worse BCR-free survival of prostate cancer patients with low Gleason score were: PCDH8 methylation in serum (Exp (B)=3.147, 95% CI: 1.152-7.961, P=0.007), clinical stage (Exp (B)=2.53, 95% CI: 1.032-4.763, P=0...
  87. Artuso C, Palladino P. How sublexical association strength modulates updating: Cognitive and strategic effects. Mem Cognit. 2018;46:285-297 pubmed publisher
    ..we used a multistep subject-based memory updating task in which we measured processing response times (RTs; Exp. 1, Exp. 2) and recognition RTs (Exp. 2)...
  88. Guan L, Luo Y, Ja W, Disney M. Small molecule alteration of RNA sequence in cells and animals. Bioorg Med Chem Lett. 2018;28:2794-2796 pubmed publisher
    ..for altering the trinucleotide expanded repeat causative of myotonic muscular dystrophy type 1 (DM1), r(CUG)exp...
  89. Bagnoli P, Vismara R, Fiore G, Costantino M. A mechanical model lung for hydraulic testing of total liquid ventilation circuits. Int J Artif Organs. 2005;28:1232-41 pubmed
    ..model of the respiratory system with different resistance values for inspiration (R insp ) or expiration (R exp ). The resistant element was set up using polypropylene hollow fibres packed inside a tube...
  90. Govender S, Dennis D, Colebatch J. Frequency and phase effects on cervical vestibular evoked myogenic potentials (cVEMPs) to air-conducted sound. Exp Brain Res. 2016;234:2567-74 pubmed publisher
    ..Zhang et al. (Exp Brain Res 213:111-116, 2011a) who did allow for ME effects were able to show a secondary peak around 100 Hz for ..
  91. Larsen M, Kress W, Schoser B, Hehr U, Muller C, Rost S. Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype. Eur J Hum Genet. 2016;24:1467-72 pubmed publisher
    ..We sequenced DMPK and CNBP - associated with DM, as well as CELF1 (CUGBP, Elav-like family member 1) and MBNL1 (muscleblind-like splicing regulator 1) - associated with the pathomechanism of DM, for pathogenic variants, ..
  92. Zhang Z, Lu J, Cong R, Ren T, Li X. Evaluating agroclimatic constraints and yield gaps for winter oilseed rape (Brassica napus L.) - A case study. Sci Rep. 2017;7:7852 pubmed publisher
    ..Farmers (Y farm ) and local agronomists (Y exp ) have achieved 63% and 86% of the attainable yield (Y att ), respectively...