MBL2

Summary

Gene Symbol: MBL2
Description: mannose binding lectin 2
Alias: COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose-binding protein C, collectin-1, mannan-binding lectin, mannose-binding lectin (protein C) 2, soluble (opsonic defect), mannose-binding lectin 2, soluble (opsonic defect)
Species: human
Products:     MBL2

Top Publications

  1. Bak Romaniszyn L, Szala A, Sokolowska A, Mierzwa G, Czerwionka Szaflarska M, Swierzko A, et al. Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease. Scand J Gastroenterol. 2011;46:1275-8 pubmed publisher
    ..b>MBL2 gene single nucleotide polymorphisms (PCR-RFLP) and MBL concentrations (ELISA) were determined...
  2. Fletcher G, Gnanamony M, Samuel P, Ismail A, Kannangai R, Daniel D, et al. Association of mannose-binding lectin polymorphisms and HBV outcome in a South Indian population. Int J Immunogenet. 2010;37:177-84 pubmed publisher
    Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection...
  3. Pine S, Mechanic L, Ambs S, Bowman E, Chanock S, Loffredo C, et al. Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J Natl Cancer Inst. 2007;99:1401-9 pubmed
    ..Five polymorphisms in the promoter and first exon of the MBL2 gene alter the expression and function of MBL in humans and are associated with inflammation-related disease ..
  4. Vianna P, Da Silva G, Dos Santos B, Bauer M, Dalmáz C, Bandinelli E, et al. Association between mannose-binding lectin gene polymorphisms and pre-eclampsia in Brazilian women. Am J Reprod Immunol. 2010;64:359-74 pubmed publisher
    ..Here, we evaluated MBL2 gene polymorphisms in the structural and promoter regions addressing their association with PE...
  5. Wang X, Saito J, Tanino Y, Ishida T, Fujita T, Munakata M. Mannose binding lectin gene polymorphisms and asthma. Clin Exp Allergy. 2007;37:1334-9 pubmed
    ..To investigate whether MBL plays roles in asthma, we analysed MBL2 polymorphisms (allele B, H/L and Y/X) and plasma MBL levels in a Japanese adult population including 232 healthy ..
  6. Charakida M, Donald A, Leary S, Halcox J, Turner M, Johnson M, et al. Endothelial response to childhood infection: the role of mannose-binding lectin (MBL). Atherosclerosis. 2010;208:217-21 pubmed publisher
    To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood...
  7. Swierzko A, Kilpatrick D, Cedzynski M. Mannan-binding lectin in malignancy. Mol Immunol. 2013;55:16-21 pubmed publisher
    ..In this paper, possible cancer associations of one of the factors activating complement via the lectin pathway, mannan-binding lectin (MBL), are discussed.
  8. de Messias Reason I, Boldt A, Moraes Braga A, Von Rosen Seeling Stahlke E, Dornelles L, Pereira Ferrari L, et al. The association between mannan-binding lectin gene polymorphism and clinical leprosy: new insight into an old paradigm. J Infect Dis. 2007;196:1379-85 pubmed
    ..The polymorphisms at the promoter and exon 1 regions of the MBL2 gene were assessed by polymerase chain reaction and sequencing performed on 264 patients with leprosy and 214 ..
  9. Gorgi Y, Sfar I, Aouadi H, Makhlouf M, Abderrahim E, Jendoubiayed S, et al. Mannose binding lectin (+54) exon 1 gene polymorphism in Tunisian kidney transplant patients. Transplant Proc. 2009;41:660-2 pubmed publisher
    Mannose-binding lectin (MBL), a collagen-like serum protein, is a key component of innate immunity. MBL binding to carbohydrates present on pathogens mediates lectin-dependent activation of the complement pathway...

More Information

Publications114 found, 100 shown here

  1. Zanetti K, Haznadar M, Welsh J, Robles A, Ryan B, McClary A, et al. 3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans. Cancer Res. 2012;72:1467-77 pubmed publisher
    ..cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility...
  2. Vasconcelos L, Fonseca J, do Carmo R, de Mendonça T, Pereira V, Lucena Silva N, et al. Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes. Int J Infect Dis. 2011;15:e551-7 pubmed publisher
    ..Therefore, a single nucleotide polymorphism (SNP) in the MBL2 gene associated with low levels of MBL could confer protection against the development of leprosy disease...
  3. Rantala A, Lajunen T, Juvonen R, Bloigu A, Silvennoinen Kassinen S, Peitso A, et al. Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. J Infect Dis. 2008;198:1247-53 pubmed publisher
    ..This exploratory study investigated the association of serum MBL concentrations and MBL2 gene polymorphisms with respiratory tract infections in young men...
  4. Monticielo O, Mucenic T, Xavier R, Brenol J, Chies J. The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol. 2008;27:413-9 pubmed publisher
    ..Recent studies proposed a role to the mannose-binding lectin (MBL) in the SLE physiopathogenesis...
  5. Kaunisto M, Sjölind L, Sallinen R, Pettersson Fernholm K, Saraheimo M, Fröjdö S, et al. Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy. Diabetes. 2009;58:1710-4 pubmed publisher
    ..We investigated whether MBL2 polymorphisms are associated with type 1 diabetes or diabetic nephropathy and whether patients with nephropathy ..
  6. van de Geijn F, Dolhain R, van Rijs W, Willemsen S, Hazes J, de Groot C. Mannose-binding lectin genotypes are associated with shorter gestational age. An evolutionary advantage of low MBL production genotypes?. Mol Immunol. 2008;45:1514-8 pubmed
    ..b>MBL2 gene polymorphisms were determined in 157 nulliparous women...
  7. Jambo K, French N, Zijlstra E, Gordon S. AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. Respir Res. 2007;8:42 pubmed
    Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV)...
  8. Tong F, Gan J, Lu Q, Cao W, Shen X. [Relationship between the gene mutations of mannose binding protein and the progression of hepatitis B infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25:331-3 pubmed
    To investigate the relationship between the gene mutations of mannose binding protein(MBP) and the progression of hepatitis B...
  9. Chen J, Xu Z, Ou X, Wang M, Yang X, Li Q. Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children. Eur J Pediatr. 2009;168:1305-13 pubmed publisher
    ..lectin (MBL) serum level in children and to investigate the correlation between the polymorphisms of MBL2 gene and serum MBL level in healthy Chinese of Han ethnic group and in children of Chinese Han ethnic group with ..
  10. Muller Y, Hanson R, Bian L, Mack J, Shi X, Pakyz R, et al. Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish. Diabetes. 2010;59:2080-5 pubmed publisher
    b>MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus...
  11. Cervera C, Balderramo D, Suarez B, Prieto J, Fuster F, Linares L, et al. Donor mannose-binding lectin gene polymorphisms influence the outcome of liver transplantation. Liver Transpl. 2009;15:1217-24 pubmed publisher
    ..Polymorphisms at the promoter and exon 1 of the MBL2 gene are responsible for low serum levels of MBL and have been associated with an increased risk of infections...
  12. Aittoniemi J, Turpeinen H, Tiittanen M, Knip M, Simell O, Ilonen J, et al. Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children. Hum Immunol. 2008;69:108-11 pubmed publisher
    ..lectin (MBL) is a key mediator of innate immunity, the insufficiency of which is caused by point mutations in the MBL2 gene...
  13. Adamek M, Heyder J, Heinold A, Fiedler G, Opelz G, Tran T. Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels. Tissue Antigens. 2013;82:410-5 pubmed publisher
    ..Several single-nucleotide polymorphisms (SNPs) in the promoter region and exon 1 of the MBL2 gene are responsible for variations in serum MBL levels...
  14. Troelsen L, Garred P, Jacobsen S. Mortality and predictors of mortality in rheumatoid arthritis--a role for mannose-binding lectin?. J Rheumatol. 2010;37:536-43 pubmed publisher
    Patients with rheumatoid arthritis (RA) have increased overall and cardiovascular mortality. Mannose-binding lectin (MBL) may play differentiated roles in the pathogenesis of RA...
  15. Dean M, Flower R, Eisen D, Minchinton R, Hart D, Vuckovic S. Mannose-binding lectin deficiency influences innate and antigen-presenting functions of blood myeloid dendritic cells. Immunology. 2011;132:296-305 pubmed publisher
    ..Individuals with mutations in exon 1 of the MBL2 gene have reduced MBL ligand binding and complement activation function and increased incidence of infection...
  16. Bilgin Y, Brand A, Berger S, Daha M, Roos A. Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusions. Transfusion. 2008;48:601-8 pubmed publisher
    Serum levels of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, are highly variable, based on genetic variation...
  17. Brown E, Zhang M, Zarin Pass R, Bernig T, Tseng F, Xiao N, et al. MBL2 and hepatitis C virus infection among injection drug users. BMC Infect Dis. 2008;8:57 pubmed publisher
    Genetic variations in MBL2 that reduce circulating levels and alter functional properties of the mannose binding lectin (MBL) have been associated with many autoimmune and infectious diseases...
  18. van Asbeck E, Hoepelman A, Scharringa J, Herpers B, Verhoef J. Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells. BMC Microbiol. 2008;8:229 pubmed publisher
    Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens...
  19. Saevarsdottir S, Steinsson K, Grondal G, Valdimarsson H. Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls. J Rheumatol. 2007;34:1692-5 pubmed
    ..and synovial fluid; its levels vary widely, and the variations are strongly associated with polymorphisms in the MBL2 gene...
  20. van de Geijn F, Dolhain R, van Rijs W, Hazes J, de Groot C. Mannose-binding lectin genotypes and pre-eclampsia: a case-control study. Hum Immunol. 2007;68:888-93 pubmed
    ..We investigated whether MBL genotypes are associated with the systemic maternal syndrome pre-eclampsia. MBL2 gene polymorphisms were determined in a case-control study including 157 women with pre-eclampsia (case subjects) ..
  21. Giraldo P, Babula O, Gonçalves A, Linhares I, Amaral R, Ledger W, et al. Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. Obstet Gynecol. 2007;109:1123-8 pubmed
    To evaluate associations between polymorphisms in the gene coding for mannose-binding lectin (MBL) and the diagnosis of acute or recurrent vulvovaginal candidiasis and bacterial vaginosis
  22. Berger S, Roos A, Mallat M, Schaapherder A, Doxiadis I, van Kooten C, et al. Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol. 2007;18:2416-22 pubmed
    ..This study therefore sought to determine how mannose-binding lectin (MBL), a major recognition molecule of the lectin pathway of complement activation, influences outcome after SPKT...
  23. Mullighan C, Heatley S, Danner S, Dean M, Doherty K, Hahn U, et al. Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation. Blood. 2008;112:2120-8 pubmed publisher
    ..We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation ..
  24. Munster J, van der Bij W, Breukink M, van der Steege G, Zuurman M, Hepkema B, et al. Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. Transplantation. 2008;86:1857-63 pubmed publisher
    ..Genotyping of the MBL2 variants (promoter: L/H, Y/X, and P/Q allele and exon 1: A/D, A/B, and A/C allele) was performed in donor and ..
  25. Alonso D, Ferreira A, Ribolla P, De Miranda Santos I, do Socorro Pires e Cruz M, Aécio de Carvalho F, et al. Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications. J Infect Dis. 2007;195:1212-7 pubmed
    ..Mutations in the MBL2 gene decrease levels of MBL and may protect against development of VL...
  26. Holmberg V, Schuster F, Dietz E, Sagarriga Visconti J, Anemana S, Bienzle U, et al. Mannose-binding lectin variant associated with severe malaria in young African children. Microbes Infect. 2008;10:342-8 pubmed publisher
    ..In a matched case-control study among 870 Ghanaian children, we examined the influence of six polymorphisms of the MBL2 gene on Plasmodium falciparum infection and severe malaria...
  27. Im C, Kim J, Lee Y, Lee E, Lee E, Park K, et al. Mannose-binding lectin 2 gene haplotype analysis in Korean patients with ankylosing spondylitis. Rheumatol Int. 2012;32:2251-5 pubmed publisher
    ..We investigated MBL2 genetic polymorphisms in 95 patients with ankylosing spondylitis (AS) and in 252 healthy controls...
  28. Ishii M, Ohsawa I, Inoshita H, Kusaba G, Onda K, Wakabayashi M, et al. Serum concentration of complement components of the lectin pathway in maintenance hemodialysis patients, and relatively higher levels of L-Ficolin and MASP-2 in Mannose-binding lectin deficiency. Ther Apher Dial. 2011;15:441-7 pubmed publisher
    Mannose-binding lectin (MBL), L-ficolin and MBL associated serine protease-2 (MASP-2) are molecules involved in initiation of the lectin pathway (LP) in the complement system...
  29. Glesse N, Monticielo O, Mattevi V, Brenol J, Xavier R, da Silva G, et al. Association of mannose-binding lectin 2 gene polymorphic variants with susceptibility and clinical progression in systemic lupus erythematosus. Clin Exp Rheumatol. 2011;29:983-90 pubmed
    ..of systemic lupus erythematosus (SLE), through the analysis of promoter region and exon 1 polymorphisms of the MBL2 gene. We analysed 325 SLE patients from the Hospital de Clínicas de Porto Alegre and 344 controls...
  30. Troelsen L, Garred P, Madsen H, Jacobsen S. Genetically determined high serum levels of mannose-binding lectin and agalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis. Arthritis Rheum. 2007;56:21-9 pubmed
    ..It has been suggested that high serum levels of mannose-binding lectin (MBL) and agalactosyl IgG (IgG-G0) are associated with increased inflammation in RA...
  31. Eisen D, Dean M, Boermeester M, Fidler K, Gordon A, Kronborg G, et al. Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis. 2008;47:510-6 pubmed publisher
    Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility...
  32. Shimizu T, Nishitani C, Mitsuzawa H, Ariki S, Takahashi M, Ohtani K, et al. Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms. Biochim Biophys Acta. 2009;1790:1705-10 pubmed publisher
    ..Mannose binding lectin (MBL) is another collectin molecule which has structural homology to SP-A...
  33. Park K, Kurokawa K, Zheng L, Jung D, Tateishi K, Jin J, et al. Human serum mannose-binding lectin senses wall teichoic acid Glycopolymer of Staphylococcus aureus, which is restricted in infancy. J Biol Chem. 2010;285:27167-75 pubmed publisher
    ..pathogens, and it is recognized by a variety of pattern recognition molecules, including mannose-binding lectin (MBL). MBL binds to mannose and N-acetylglucosamine residues present on the glycopolymers of microorganisms...
  34. Ou X, Wu J, Zhu L, Guan M, Xu B, Hu X, et al. Genotypes coding for mannose-binding lectin deficiency correlated with cryptococcal meningitis in HIV-uninfected Chinese patients. J Infect Dis. 2011;203:1686-91 pubmed publisher
    ..Patients with cryptococcal meningitis and control subjects were genotyped for 6 alleles of MBL2 gene (H/L, Y/X, P/Q, A/D, A/B, and A/C)...
  35. Than N, Romero R, Erez O, Kusanovic J, Tarca A, Edwin S, et al. A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia. Am J Reprod Immunol. 2008;60:333-45 pubmed publisher
    ..Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia...
  36. Valles X, Roca A, Lozano F, Morais L, Suarez B, Casals F, et al. Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency. Eur Respir J. 2010;36:856-63 pubmed publisher
    ..We aimed to determine the association between invasive pneumococcal disease and MBL2 and MASP2 genetic variants, regarding serotype distribution...
  37. Araujo J, Brandão L, Guimarães R, Santos S, Falcão E, Milanese M, et al. Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents. Hum Immunol. 2007;68:739-43 pubmed
    ..constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphisms in exon 1, as well as nucleotide variations in the promoter region of the gene, have been ..
  38. Brouwer N, Frakking F, van de Wetering M, van Houdt M, Hart M, Budde I, et al. Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels. J Immunol. 2009;183:3496-504 pubmed publisher
    Mannose-binding lectin (MBL) deficiency is often associated with an increased risk of infection or worse prognosis in immunocompromised patients. MBL substitution in these patients might diminish these risks...
  39. Antony J, Ojurongbe O, Van Tong H, Ouf E, Engleitner T, Akindele A, et al. Mannose-binding lectin and susceptibility to schistosomiasis. J Infect Dis. 2013;207:1675-83 pubmed publisher
    Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious ..
  40. Wang M, Wang F, Yang J, Zhao D, Wang H, Shao F, et al. Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4. PLoS ONE. 2013;8:e83517 pubmed publisher
    ..Mannan-binding lectin (MBL),a member of the collectin family in the C-type lectin superfamily, is an important serum component associated with ..
  41. Mellbin L, Hamsten A, Malmberg K, Steffensen R, Ryden L, Ohrvik J, et al. Mannose-binding lectin genotype and phenotype in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial. Diabetes Care. 2010;33:2451-6 pubmed publisher
    The present study characterizes mannose-binding lectin (MBL), an activator of the complement system and thereby important for inflammatory activation, in patients with diabetes and myocardial infarction...
  42. Troelsen L, Garred P, Christiansen B, Torp Pedersen C, Jacobsen S. Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus. J Rheumatol. 2010;37:1815-21 pubmed publisher
    ..Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and ..
  43. Vuononvirta J, Toivonen L, Gröndahl Yli Hannuksela K, Barkoff A, Lindholm L, Mertsola J, et al. Nasopharyngeal bacterial colonization and gene polymorphisms of mannose-binding lectin and toll-like receptors 2 and 4 in infants. PLoS ONE. 2011;6:e26198 pubmed publisher
    ..Gene polymorphisms in mannose-binding lectin (MBL), toll-like receptor (TLR) 2 and TLR4 have been reported...
  44. Maury C, Aittoniemi J, Tiitinen S, Laiho K, Kaarela K, Hurme M. Variant mannose-binding lectin 2 genotype is a risk factor for reactive systemic amyloidosis in rheumatoid arthritis. J Intern Med. 2007;262:466-9 pubmed
    The aim of this study was to investigate whether polymorphism of the mannose-binding lectin 2 (MBL2) gene is related to the occurrence of systemic AA amyloidosis in patients with rheumatoid arthritis (RA)...
  45. Jensenius H, Klein D, van Hecke M, Oosterkamp T, Schmidt T, Jensenius J. Mannan-binding lectin: structure, oligomerization, and flexibility studied by atomic force microscopy. J Mol Biol. 2009;391:246-59 pubmed publisher
    Mannan-binding lectin (MBL) is the archetypical pathogen recognition molecule of the innate immune defense. Upon binding to microorganisms, reactions leading to the destruction of the offender ensue...
  46. Satomura A, Fujita T, Yanai M, Kumasaka K, Uehara Y, Okada K, et al. Functional mannose-binding lectin levels in patients with end-stage renal disease on maintenance hemodialysis. J Innate Immun. 2012;4:293-300 pubmed publisher
    Innate immunity is generally impaired in chronic renal failure (CRF). Mannose-binding lectin (MBL) has an important role in first-line host defense against pathogens via the lectin pathway...
  47. Eisen D, Dean M, O Sullivan M, Heatley S, Minchinton R. Mannose-binding lectin deficiency does not appear to predispose to cryptococcosis in non-immunocompromised patients. Med Mycol. 2008;46:371-5 pubmed publisher
    ..MBL function and levels, as well as MBL2 genotype were determined in 36 HIV-negative cryptococcosis patients (25 with CNS involvement) using C4 deposition ..
  48. Thévenon A, Leke R, Suguitan A, Zhou J, Taylor D. Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries. Infect Immun. 2009;77:1483-91 pubmed publisher
    ..To test this hypothesis, molecular genotyping was used to detect polymorphisms at codon 57 (A/C) in exon 1 of MBL2 in 401 pregnant Cameroonian women, with or without placental malaria, who had LBW and normal-weight babies...
  49. Denholm J, McBryde E, Eisen D. Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol. 2010;162:84-90 pubmed publisher
    ..We performed a literature review and meta-analysis of 17 human trials considering the effect of MBL2 genotype and/or MBL levels and TB infection...
  50. Harrison E, Singh A, Morris J, Smith N, Fraczek M, Moore C, et al. Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis. Int J Immunogenet. 2012;39:224-32 pubmed publisher
    ..DNA was extracted from blood samples, and MBL2 genotyping was performed using the INNO-LiPA MBL2 kit. Serum MBL concentrations were determined using ELISA...
  51. Chalmers J, McHugh B, Doherty C, Smith M, Govan J, Kilpatrick D, et al. Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study. Lancet Respir Med. 2013;1:224-32 pubmed publisher
    Mannose-binding lectin (MBL) is a key component of innate immunity. MBL deficiency is common (10-30% of the general population depending on the definition used) and has been associated with disease progression in cystic fibrosis...
  52. Martinez Lopez J, Rivero A, Rapado I, Montalban C, Paz Carreira J, Canales M, et al. Influence of MBL-2 mutations in the infection risk of patients with follicular lymphoma treated with rituximab, fludarabine, and cyclophosphamide. Leuk Lymphoma. 2009;50:1283-9 pubmed publisher
    ..The aim of the present study was to analyze mannose-binding lectin (MBL-2 gene) mutations and their association with severe infections and event-free survival in patients diagnosed with ..
  53. Cervera A, Planas A, Justicia C, Urra X, Jensenius J, Torres F, et al. Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS ONE. 2010;5:e8433 pubmed publisher
    ..In order to investigate the clinical relevance of these experimental observations, a study of MBL2 and MASP-2 gene polymorphism rendering the lectin pathway dysfunctional was performed in 135 stroke patients...
  54. Carréra M, Moura P, Crovella S, de Souza P, de Alencar L, Sarinho E. High polymorphism of the MBL2 gene in patients with atopic dermatitis. Ann Allergy Asthma Immunol. 2010;105:39-42 pubmed publisher
    Low serum levels of mannose-binding lectin (MBL) are determined mainly by variant alleles of the MBL2 gene and it has been suggested that MBL may play a role in the susceptibility to atopic dermatitis (AD)...
  55. Siezenga M, Shaw P, Daha M, Rabelink T, Berger S. Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South Asians. A prospective cohort study. Cardiovasc Diabetol. 2011;10:60 pubmed publisher
    ..Mannose-Binding Lectin (MBL), which activates the lectin pathway of complement activation, has been introduced as a risk marker of vascular ..
  56. Nuolivirta K, He Q, Gröndahl Yli Hannuksela K, Koponen P, Korppi M, Helminen M. Mannose-binding lectin gene polymorphisms in infants with bronchiolitis and post-bronchiolitis wheezing. Allergol Int. 2012;61:305-9 pubmed publisher
    Mannose-binding lectin (MBL) encoded by the MBL2 gene, is an important component of the innate immunity. Low levels have been linked with respiratory infections and both high and low levels with allergy and asthma...
  57. Eurich D, Boas Knoop S, Yahyazadeh A, Neuhaus R, Somasundaram R, Ruehl M, et al. Role of mannose-binding lectin-2 polymorphism in the development of acute cellular rejection after transplantation for hepatitis C virus-induced liver disease. Transpl Infect Dis. 2012;14:488-95 pubmed publisher
    ..Mannose-binding lectin-2 (MBL-2) is an important immunomodulatory factor that is involved in complement activation...
  58. Hellemann D, Larsson A, Madsen H, Bonde J, Jarløv J, Wiis J, et al. Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients. Hum Mol Genet. 2007;16:3071-80 pubmed
    Polymorphisms in the MBL2 gene, which affect the structure and influence on the serum concentration of mannose-binding lectin (MBL), are associated with inflammatory and infectious conditions...
  59. Donders G, Babula O, Bellen G, Linhares I, Witkin S. Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis. BJOG. 2008;115:1225-31 pubmed publisher
    Women with recurrent vulvovaginal candidiasis (RVC) due to a polymorphism in codon 54 of the MBL2 gene respond better to fluconazole maintenance therapy than do women with other underlying causes.
  60. Pesonen E, Hallman M, Sarna S, Andsberg E, Haataja R, Meri S, et al. Mannose-binding lectin as a risk factor for acute coronary syndromes. Ann Med. 2009;41:591-8 pubmed publisher
    Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events. Controlled cohort study...
  61. Kim J, Im C, Kang E, Lee E, Lee Y, Park K, et al. Mannose-binding lectin gene-2 polymorphisms and serum mannose-binding lectin levels in Behçet's disease. Clin Exp Rheumatol. 2009;27:S13-7 pubmed
    ..We investigated MBL2 gene polymorphisms and serum MBL levels in BD patients and controls...
  62. Kwakkel van Erp J, Paantjens A, van Kessel D, Grutters J, van den Bosch J, van de Graaf E, et al. Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation. Clin Exp Immunol. 2011;165:410-6 pubmed publisher
    ..Mannose-binding lectin (MBL) is a pattern recognition molecule of complement and an important component of the innate immunity...
  63. Michaud D, Siddiq A, Cox D, Backes D, Calboli F, Sughrue M, et al. Mannose-binding lectin 2 gene and risk of adult glioma. PLoS ONE. 2013;8:e61117 pubmed publisher
    ..85 single nucleotide polymorphisms (SNPs) in 9 genes in the lectin complement pathway and 3 additional SNPs in MBL2 were tested post hoc)...
  64. van de Geijn F, Hazes J, Geleijns K, Emonts M, Jacobs B, Dufour van den Goorbergh B, et al. Mannose-binding lectin polymorphisms are not associated with rheumatoid arthritis--confirmation in two large cohorts. Rheumatology (Oxford). 2008;47:1168-71 pubmed publisher
    ..Therefore a different approach is warranted. MBL2 gene polymorphisms were determined in two RA cohorts (378 and 261 cases) and 648 controls...
  65. Henckaerts L, Nielsen K, Steffensen R, Van Steen K, Mathieu C, Giulietti A, et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med. 2009;37:192-201, e1-3 pubmed publisher
  66. St Swierzko A, Cedzynski M, Domzalska Popadiuk I, MacDonald S, Borkowska Klos M, Atkinson A, et al. Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations. Mol Immunol. 2009;46:1696-701 pubmed publisher
    One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway...
  67. Potlukova E, Jiskra J, Freiberger T, Limanova Z, Zivorova D, Malickova K, et al. The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. Clin Immunol. 2010;136:123-9 pubmed publisher
    ..Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals...
  68. Saevarsdottir S, Ding B, Steinsson K, Grondal G, Valdimarsson H, Alfredsson L, et al. Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers. Arthritis Res Ther. 2011;13:R65 pubmed publisher
    Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA)...
  69. Wojitani M, de Aguiar L, Baracat E, Linhares I. Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis. Arch Gynecol Obstet. 2012;285:149-53 pubmed publisher
    ..RVVC and 100 control women and tested by gene amplification for a single nucleotide polymorphism in codon 54 of the MBL2 gene and for a length polymorphism in intron 2 of the IL1RN gene...
  70. Segat L, Fabris A, Padovan L, Milanese M, Pirulli D, Lupo F, et al. MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma. J Viral Hepat. 2008;15:387-91 pubmed publisher
    ..In our study, we analysed two MBL2 and MASP2 functional polymorphisms (MBL2 allele A/0 and MASP2 D120G) as well as MASP2 polymorphism (Y371D) ..
  71. Wang F, Tahara T, Arisawa T, Shibata T, Yamashita H, Nakamura M, et al. Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population. Dig Dis Sci. 2008;53:2904-8 pubmed publisher
    ..It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity...
  72. Christiansen O, Nielsen H, Lund M, Steffensen R, Varming K. Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses. Hum Reprod. 2009;24:291-9 pubmed publisher
    ..Polymorphisms in the MBL2 gene associated with plasma MBL levels were investigated in all patients and in 104 women with two or more children ..
  73. Segat L, Crovella S, Comar M, Milanese M, Zanotta N, Fabris A, et al. MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus-related cervical cancer. Hum Immunol. 2009;70:436-9 pubmed publisher
    We investigated whether there is a correlation between MBL2 polymorphisms and the host susceptibility to human papillomavirus (HPV) infection and cancer development...
  74. Matthijsen R, de Winther M, Kuipers D, van der Made I, Weber C, Herias M, et al. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2009;119:2188-95 pubmed publisher
    With consideration of the central role of the innate immune system in atherogenesis and mannose-binding lectin (MBL) as an innate regulator of immunity, the role of MBL in experimental and human atherosclerosis was assessed...
  75. Filho R, Carmo R, Catsman C, Souza C, Silva A, Moura P, et al. High frequency of variant alleles of the mannose-binding lectin 2 (MBL2) gene are associated with patients infected by hepatitis B virus. Viral Immunol. 2010;23:449-53 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) in the first exon and promoter region of the mannose-binding lectin gene 2 (MBL2) situated on chromosome 10, with susceptibility to HBV infection...
  76. Guimaraes V, Guimaraes R, Brandao L, Baldez da Silva M, Milanese M, Segat L, et al. Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women. Hum Immunol. 2008;69:273-8 pubmed publisher
    We studied the association between high-risk human papillomavirus (HPV) infection and MBL2 functional polymorphisms in a group of 180 high-risk HPV-infected women and 180 healthy control subjects...
  77. Boldt A, Messias Reason I, Lell B, Issifou S, Pedroso M, Kremsner P, et al. Haplotype specific-sequencing reveals MBL2 association with asymptomatic Plasmodium falciparum infection. Malar J. 2009;8:97 pubmed publisher
    ..Frequent polymorphisms found in the MBL2 gene affect the concentration and functionality of the protein and are associated with enhanced susceptibility to ..
  78. Troelsen L, Garred P, Christiansen B, Torp Pedersen C, Christensen I, Narvestad E, et al. Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis. Mol Immunol. 2010;47:713-8 pubmed publisher
    ..We examined the relation between ccIMT and MBL in 114 RA patients. In a cross-sectional study MBL2 genotypes and serum concentrations of MBL were assessed; ccIMT was determined by means of ultrasonography; ..
  79. Chalmers J, Fleming G, Hill A, Kilpatrick D. Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis. Glycobiology. 2011;21:271-82 pubmed publisher
    ..In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P &..
  80. Sandrin Garcia P, Brandão L, Coelho A, Guimaraes R, Pancoto J, Segat L, et al. Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians. Hum Immunol. 2011;72:516-21 pubmed publisher
    ..To uncover a possible association between MBL2 gene polymorphisms and SLE, we analyzed functional polymorphisms in the promoter and first exon of the MBL2 gene in ..
  81. Chang W, White M, Moyo P, McClear S, Thiel S, Hartshorn K, et al. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010;11:64 pubmed publisher
    Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility...
  82. Eurich D, Boas Knoop S, Morawietz L, Neuhaus R, Somasundaram R, Ruehl M, et al. Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma. Liver Int. 2011;31:1006-12 pubmed publisher
    ..Mannose-binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis...
  83. Best L, Ferrell R, DeCroo S, North K, Maccluer J, Zhang Y, et al. Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study. BMC Med Genet. 2009;10:5 pubmed publisher
    ..MBL gene (MBL2) variants with between 12 to 25% allele frequency in Caucasian and other populations, result in markedly reduced ..
  84. Wang M, Zhang Y, Chen Y, Zhang L, Lu X, Chen Z. Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide. BMC Immunol. 2011;12:1 pubmed publisher
    Mannan-binding lectin (MBL) is a pattern-recognition molecule present in serum, which is involved in the innate immune defense by activating complement and promoting opsonophagocytosis...
  85. Ferdinands J, Denison A, Dowling N, Jost H, Gwinn M, Liu L, et al. A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults. Emerg Infect Dis. 2011;17:2294-302 pubmed publisher
    ..Fatal cases with low-producing MBL2 genotypes had a 7-fold increased risk for invasive methicillin-resistant Staphylococcus aureus (MRSA) co-infection ..
  86. Heitzeneder S, Seidel M, Forster Waldl E, Heitger A. Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?. Clin Immunol. 2012;143:22-38 pubmed publisher
    ..b>MBL2 gene polymorphisms are associated with quantitative and qualitative MBL abnormalities in the serum...
  87. Garcia Laorden M, Rodriguez de Castro F, Sole Violan J, Payeras A, Briones M, Borderias L, et al. The role of mannose-binding lectin in pneumococcal infection. Eur Respir J. 2013;41:131-9 pubmed publisher
    The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial...
  88. Xie Q, Wang S, Bian G, Zhan F, Xie J, Li J. Association of MIF-173G/C and MBL2 codon 54 gene polymorphisms with rheumatoid arthritis: a meta-analysis. Hum Immunol. 2012;73:966-71 pubmed publisher
    ..the association between macrophage migration inhibitory factor (MIF) -173G/C (rs755622), mannose-binding lectin (MBL2) exon 1 codon 54 (rs1800450) gene polymorphisms and rheumatoid arthritis (RA) susceptibility in ethnically ..
  89. Bay J, Sørensen S, Hansen J, Madsen H, Garred P. Low mannose-binding lectin serum levels are associated with reduced kidney graft survival. Kidney Int. 2013;83:264-71 pubmed publisher
    ..Variant MBL2 genotypes causing low mannose-binding lectin serum concentrations showed the same association pattern...
  90. Carroll K, Dean M, Heatley S, Meehan A, Mifsud N, Kotsimbos T, et al. High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation. Transplantation. 2011;91:1044-9 pubmed publisher
    ..We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR)...
  91. Comar M, Segat L, Crovella S, Bovenzi M, Cortini E, Tognon M. The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus-positive cervical lesions. Hum Immunol. 2011;72:663-6 pubmed publisher
    ..To disclose a possible role of the gene encoding for the mannose-binding lectin, MBL2, in susceptibility to BKV infection, we analyzed functional polymorphisms in the first exon of MBL2 in women ..
  92. Martiny F, Veit T, Brenol C, Brenol J, Xavier R, Bogo M, et al. Mannose-binding lectin gene polymorphisms in Brazilian patients with rheumatoid arthritis. J Rheumatol. 2012;39:6-9 pubmed publisher
    ..Mannose-binding lectin (MBL) is an important protein of the human innate immune system, encoded by the MBL2 gene...