MBD1

Summary

Gene Symbol: MBD1
Description: methyl-CpG binding domain protein 1
Alias: CXXC3, PCM1, RFT, methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, methyl-CpG binding domain protein 1 isoform PCM1, protein containing methyl-CpG-binding domain 1, the regulator of fibroblast growth factor 2 (FGF-2) transcription
Species: human
Products:     MBD1

Top Publications

  1. Bierne H, Tham T, Batsche E, Dumay A, Leguillou M, Kernéis Golsteyn S, et al. Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A. 2009;106:13826-31 pubmed publisher
    ..This nuclear protein interacts with HP1, MBD1, HDAC5, and several transcription factors...
  2. Ng H, Jeppesen P, Bird A. Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol. 2000;20:1394-406 pubmed
    b>MBD1 belongs to a family of mammalian proteins that share a methyl-CpG binding domain...
  3. Fujita N, Shimotake N, Ohki I, Chiba T, Saya H, Shirakawa M, et al. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol Cell Biol. 2000;20:5107-18 pubmed
    ..MBD1 has at least five isoforms due to alternative splicing events, resulting in the presence of CXXC1, CXXC2, and CXXC3 in MBD1 isoforms v1 (MBD1v1) and MBD1v2, and CXXC1 and CXXC2 in MBD1v3 and -v4...
  4. Patra S, Patra A, Zhao H, Carroll P, Dahiya R. Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2. Biochem Biophys Res Commun. 2003;302:759-66 pubmed
    We analyzed gene expression of MBD1, MBD2, MBD3, MBD4, and MeCP2 and protein expression of MBD1, MBD2, and MeCP2 in prostate cancer cell lines, benign prostate epithelium (BPH-1) cell line, 49 BPH tissues, and 46 prostate cancer tissues...
  5. Wischnewski F, Friese O, Pantel K, Schwarzenbach H. Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. Mol Cancer Res. 2007;5:749-59 pubmed
    ..mechanism underlying methylation-dependent repression, we examined the involvement of methyl-CpG binding proteins, MBD1, MBD2a, and MeCP2, in silencing of MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 genes...
  6. Wang J, Lu J, Xie X, Xiong J, Huang N, Wei H, et al. Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7. Int Immunopharmacol. 2018;58:64-71 pubmed publisher
    ..the expression of tight junction proteins occludin and ZO-1, mucus protein MUC-2, and host defense peptides mBD1, mBD2 and mBD3. Finally, OM1 and OM2 increased the population of Lactobacillus spp. and Bifidobacterium spp...
  7. Çelik S, Li Y, O Neill C. The effect of DNA damage on the pattern of immune-detectable DNA methylation in mouse embryonic fibroblasts. Exp Cell Res. 2015;339:20-34 pubmed publisher
    ..The methyl binding protein, MBD1, was a less reliable measure of changes in 5 meC, with a significant fraction of 5 meC not being marked by MBD1...
  8. Wang Y, Lin Z, Zheng H, Zhang S, Zhang Z, Chen Y, et al. Abnormal DNA methylation in the lumbar spinal cord following chronic constriction injury in rats. Neurosci Lett. 2016;610:1-5 pubmed publisher
    ..DNMT3a, DNMT3b and methyl-CpG binding protein 2 (MeCP2) expression increased, MBD2 expression decreased, and DNMT1, MBD1 and MBD3 expression hardly changed in the lumbar spinal cord in CCI rats on day 14 after surgery...
  9. Yamazaki T, Hatano Y, Handa T, Kato S, Hoida K, Yamamura R, et al. Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase. PLoS ONE. 2017;12:e0177764 pubmed publisher
    ..at the first mitotic stage were dramatically highlighted by the mCherry-tagged methyl CpG binding domain of human MBD1 (mCherry-MBD-NLS)...

More Information

Publications133 found, 100 shown here

  1. Arosh J, Lee J, Starzinski Powitz A, Banu S. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells. Mol Cell Endocrinol. 2015;409:51-8 pubmed publisher
    ..increases expression of H3K4me3, H3H9ac, H3K27ac; and (iii) does not modulate the expression of DNMT1, hSET1, LSD1, MBD1, p300, HDAC2, and JMJD3 epigenetic machinery proteins in an epithelial and stromal cell specific manner...
  2. Hsu T, Lin S, Lu P, Chang W, Hung C, Yeh Y, et al. MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy. Oncogene. 2015;34:826-37 pubmed publisher
    ..anaplastic lymphoma kinase (ALK), HIF1a and CBLB, and decreased the expression of tumor suppressors including BRD4, PCM1, TFG and KLF6 by modulating mRNA stability through binding to the 3'-untranslated regions of their transcripts, ..
  3. Marco A, Kisliouk T, Tabachnik T, Weller A, Meiri N. DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring. Diabetes. 2016;65:2258-67 pubmed publisher
    ..An increase in CpG methylation at the Poxmc promoter enables binding of methyl-binding domain 1 (MBD1) to 5mC, but not to its derivative 5hmC...
  4. Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, et al. LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. Nat Commun. 2018;9:3622 pubmed publisher
    ..expressed genes (PEG) were largely absent from BAT and we demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper...
  5. Lv P, Tian S, Feng C, Li J, Yu D, Jin L, et al. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016;6:36805 pubmed publisher
    ..Furthermore, Dnmt3a and Mbd1 were obviously down-regulated in thyroids of the high E2 group...
  6. Chung A, Hou Y, Ohgami R, Von Gehr A, Fisk D, Roskin K, et al. A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia. Cancer Genet. 2017;216-217:10-15 pubmed publisher
    ..with FLT3 fusion genes exhibit similar clinicopathologic features to, and should be included in, the WHO category of "Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2."
  7. Sharpe S, Koehler S, Kuckuk R, Serrano M, Vela P, Mendelson J, et al. Locomotor benefits of being a slender and slick sand swimmer. J Exp Biol. 2015;218:440-50 pubmed publisher
    ..The average βs was smaller for the snake than for the sandfish; granular resistive force theory (RFT) revealed that the curvature utilized by each animal optimized its performance...
  8. Pettersson M, Viljakainen H, Loid P, Mustila T, Pekkinen M, Armenio M, et al. Copy Number Variants Are Enriched in Individuals With Early-Onset Obesity and Highlight Novel Pathogenic Pathways. J Clin Endocrinol Metab. 2017;102:3029-3039 pubmed publisher
    ..Expression analysis of 37 candidate genes showed discordant expression for 10 genes (PCM1, EFEMP1, MAMLD1, ACP6, BAZ2B, SORBS1, KLF15, MACROD2, ATR, and MBD5)...
  9. Alabert C, Bukowski Wills J, Lee S, Kustatscher G, Nakamura K, de Lima Alves F, et al. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. Nat Cell Biol. 2014;16:281-93 pubmed publisher
    ..as CAF-1, DNMT1 and SUV39h1 are enriched in nascent chromatin, whereas 170 factors including histone H1, DNMT3, MBD1-3 and PRC1 show delayed association...
  10. Hendriks I, Treffers L, Verlaan de Vries M, Olsen J, Vertegaal A. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. Cell Rep. 2015;: pubmed publisher
    ..SUMOylated chromatin modifiers include JARID1B/KDM5B, JARID1C/KDM5C, p300, CBP, PARP1, SetDB1, and MBD1. Whereas SUMOylated JARID1B was ubiquitylated by the SUMO-targeted ubiquitin ligase RNF4 and degraded by the ..
  11. Thapa S, Pattathil S, Hahn M, Jacques M, Gilbertson R, Coaker G. Genomic Analysis of Clavibacter michiganensis Reveals Insight Into Virulence Strategies and Genetic Diversity of a Gram-Positive Bacterial Pathogen. Mol Plant Microbe Interact. 2017;30:786-802 pubmed publisher
    ..Plasmid profiles of the California strains were variable and supported the essential role of the pCM1-like plasmid and the CelA cellulase in virulence, whereas the absence of the pCM2-like plasmid in some pathogenic C...
  12. Insolera R, Shao W, Airik R, Hildebrandt F, Shi S. SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex. Neuron. 2014;83:805-22 pubmed publisher
    ..Moreover, SDCCAG8 interacts and cotraffics with pericentriolar material 1 (PCM1), a centriolar satellite protein crucial for targeting proteins to the centrosome...
  13. Wood K, Johnson B, Welsh S, Lee J, Cui Y, Krizman E, et al. Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions. Epigenomics. 2016;8:455-73 pubmed publisher
    ..We analyzed behavioral phenotypes, generated biotin-tagged MBD1 and MBD2 knockin mice, and performed biochemical studies of MBD2-NuRD...
  14. Brzozowska E, Koba M, Smietana M, Górska S, Janik M, Gamian A, et al. Label-free Gram-negative bacteria detection using bacteriophage-adhesin-coated long-period gratings. Biomed Opt Express. 2016;7:829-40 pubmed publisher
    ..coli O111 (PCM418), Klebsiella pneumoniae O1 (PCM1) and Yersinia enterocolitica O1 (PCM1879)...
  15. Conkar D, Culfa E, Odabasi E, Rauniyar N, Yates J, Firat Karalar E. The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking. J Cell Sci. 2017;130:1450-1462 pubmed publisher
    ..satellite proteins, and co-immunoprecipitation experiments revealed interactions between CCDC66, CEP290 and PCM1. Ciliogenesis, ciliary recruitment of BBS4 and centriolar satellite organization are impaired in cells depleted for ..
  16. Sánchez Domínguez B, López López J, Jané Salas E, Castellanos Cosano L, Velasco Ortega E, Segura Egea J. Glycated hemoglobin levels and prevalence of apical periodontitis in type 2 diabetic patients. J Endod. 2015;41:601-6 pubmed publisher
    ..5% of diabetic patients; this percentage was comparable in both HbA1c groups (P = .68). The prevalence of RPLs in RFT (29.6%) was similar in the GCG compared with the PCG (P = .94)...
  17. Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres Quesada O, et al. Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat Commun. 2018;9:1224 pubmed publisher
    ..At centriolar satellites, we identify a multimeric complex nucleated by PCM1 that includes two kinases, NEK10 and PKA, and the E3 ubiquitin ligase CHIP...
  18. Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, et al. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. J Cell Sci. 2016;129:621-36 pubmed publisher
    ..We show that WDR8 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component Cep135...
  19. Farina F, Gaillard J, Guérin C, Couté Y, Sillibourne J, Blanchoin L, et al. The centrosome is an actin-organizing centre. Nat Cell Biol. 2016;18:65-75 pubmed publisher
    ..Pericentriolar material 1 (PCM1) seemed to modulate the centrosomal actin network by regulating Arp2/3 complex and WASH recruitment to the ..
  20. Mühldorf B, Wolf R. C-H Photooxygenation of Alkyl Benzenes Catalyzed by Riboflavin Tetraacetate and a Non-Heme Iron Catalyst. Angew Chem Int Ed Engl. 2016;55:427-30 pubmed publisher
    A mixture of the photocatalyst riboflavin tetraacetate (RFT) and the biomimetic non-heme iron complex [Fe(TPA)(MeCN)2](ClO4)2 (TPA = tris(2-pyridylmethyl)amine) efficiently catalyzes the visible-light-driven aerobic oxidation of alkyl ..
  21. Yu C, Lee W, Nokhrin S, Dmitriev O. The Structure of Metal Binding Domain 1 of the Copper Transporter ATP7B Reveals Mechanism of a Singular Wilson Disease Mutation. Sci Rep. 2018;8:581 pubmed publisher
    ..ATP7B contains a chain of six cytosolic metal-binding domains (MBDs), the first four of which (MBD1-4) are believed to be regulatory, and the last two (MBD5-6) are required for enzyme activity...
  22. Sandgren J, Holm S, Marino A, Asmundsson J, Grillner P, Nister M, et al. Whole Exome- and mRNA-Sequencing of an AT/RT Case Reveals Few Somatic Mutations and Several Deregulated Signalling Pathways in the Context of SMARCB1 Deficiency. Biomed Res Int. 2015;2015:862039 pubmed publisher
    ..genes affected by predicted damaging germline variants that were expressed were detected (KDM5C, NUMA1, and PCM1)...
  23. De Groot F, Morrens M, Dom G. [Acceptance and commitment therapy (ACT) and addiction: a literature review]. Tijdschr Psychiatr. 2014;56:577-85 pubmed
    ..commitment therapy (ACT) is a recent form of cognitive behavioural therapy, based on the relational frame theory (RFT). act is being used to treat a wide range of problems, including addiction...
  24. Pataky T, Vanrenterghem J, Robinson M. Two-way ANOVA for scalar trajectories, with experimental evidence of non-phasic interactions. J Biomech. 2015;48:186-9 pubmed publisher
    ..statistical testing can be conducted directly on those summary statistic trajectories using Random Field Theory (RFT)...
  25. Zoubovsky S, Oh E, Cash Padgett T, Johnson A, Hou Z, Mori S, et al. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Neurosci Res. 2015;98:45-9 pubmed publisher
    ..Here, we show that mice haploinsufficient for Pericentriolar material 1 (Pcm1(+/-)), which encodes a component of the PCM found to bear rare loss of function mutations in patients with ..
  26. Harte C, Barnes Holmes D, Barnes Holmes Y, McEnteggart C. The impact of high versus low levels of derivation for mutually and combinatorially entailed relations on persistent rule-following. Behav Processes. 2018;157:36-46 pubmed publisher
    ..responding (AARR), with regards to rules, has come to be of particular interest within Relational Frame Theory (RFT)...
  27. Czerska M, Mikołajewska K, Zieliński M, Gromadzińska J, Wąsowicz W. Today's oxidative stress markers. Med Pr. 2015;66:393-405 pubmed publisher
    ..Stres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów...
  28. Furihata C, Toyoda T, Ogawa K, Suzuki T. Using RNA-Seq with 11 marker genes to evaluate 1,4-dioxane compared with typical genotoxic and non-genotoxic rat hepatocarcinogens. Mutat Res. 2018;834:51-55 pubmed publisher
    ..Previously, we selected 11 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) to discriminate GTHCs and NGTHCs...
  29. Liu C, Teng Z, Santistevan N, Szulwach K, Guo W, Jin P, et al. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010;6:433-44 pubmed publisher
    Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-mediated epigenetic mechanism...
  30. Yao P, Hong T, Wang Z, Ma J, Zhu Y, Li H, et al. Treatment of bilateral idiopathic trigeminal neuralgia by radiofrequency thermocoagulation at different temperatures. Medicine (Baltimore). 2016;95:e4274 pubmed publisher
    Radiofrequency thermocoagulation (RFT) is an effective treatment for trigeminal neuralgia, but consensus regarding an optimal treatment temperature is lacking...
  31. Liu C, Teng Z, McQuate A, Jobe E, Christ C, von Hoyningen Huene S, et al. An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation. PLoS ONE. 2013;8:e51436 pubmed publisher
    ..Methyl-CpG binding protein 1 (MBD1), an important epigenetic regulator of adult neurogenesis, controls the proliferation and differentiation of adult ..
  32. Özkan S, Yazici Ã, Aydin E, KaraoÄŸlanoÄŸlu N. Is surgical plication necessary in diaphragm eventration?. Asian J Surg. 2016;39:59-65 pubmed publisher
    ..has any effect on respiration by analyzing the patients' changing values in the respiratory function test (RFT) after plication surgery...
  33. Wang Q, Tang Y, Xu Y, Xu S, Jiang Y, Dong Q, et al. The X-linked deubiquitinase USP9X is an integral component of centrosome. J Biol Chem. 2017;292:12874-12884 pubmed publisher
    ..Interestingly, we showed that USP9X promotes stabilization of centrosome proteins PCM1 and CEP55 through its catalytic activity...
  34. Moya Plana A, Auperin A, Guerlain J, Gorphe P, Casiraghi O, Mamelle G, et al. Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis. Oral Oncol. 2018;82:187-194 pubmed publisher
    ..of sentinel node biopsy (SNB) in T1/T2 cN0 oral squamous cell carcinoma (OSCC), and compare recurrence-free time (RFT) and overall survival (OS) between patients undergoing SNB and neck dissection (ND)...
  35. Li L, Chen B, Chan W. An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1). Int J Mol Sci. 2015;16:5125-40 pubmed publisher
    ..This binding allows it to trigger methylation of H3K9 and results in transcriptional repression. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA...
  36. Lin C. Promote health or prevent disease? The effects of health-related advertising on eating behavior intention. Int J Environ Res Public Health. 2015;12:3517-34 pubmed publisher
    ..of health-related advertisements (ads) on healthy behavior intentions as influenced by regulatory focus theory (RFT) and construal level theory (CLT). We conducted an experiment with different public health advocacy ads...
  37. Segura Egea J, Martín González J, Cabanillas Balsera D, Fouad A, Velasco Ortega E, Lopez Lopez J. Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis. Clin Oral Investig. 2016;20:1133-41 pubmed publisher
    ..on the association between diabetes and the presence of radiolucent periapical lesions (RPLs) in root-filled teeth (RFT)...
  38. Hori A, Barnouin K, Snijders A, Toda T. A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. EMBO Rep. 2016;17:326-37 pubmed publisher
    ..Plk4 interacts with the satellite component PCM1, and its kinase activity is required for phosphorylation of the conserved S372...
  39. Zampedri E, Romanelli F, Semeraro F, Parolini B, Frisina R. Spectral-domain optical coherence tomography findings in idiopathic lamellar macular hole. Graefes Arch Clin Exp Ophthalmol. 2017;255:699-707 pubmed publisher
    ..atypical ERM), integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), residual foveal thickness (RFT) micron (?), maximal diameter of intraretinal splitting (MDIRS) (?)...
  40. Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, et al. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Biomarkers. 2008;13:607-17 pubmed
    Polymorphisms of the methyl-CpG binding domain 1 (MBD1) gene may influence MBD1 activity on gene expression profiles, thereby modulating individual susceptibility to lung cancer...
  41. Biggar Y, Storey K. Global DNA modifications suppress transcription in brown adipose tissue during hibernation. Cryobiology. 2014;69:333-8 pubmed publisher
    ..5- and 6-fold, respectively. Protein levels of two co-repressors of transcription, MBD1 and HP1, also increased by 1.9- and 1...
  42. Pataky T, Vanrenterghem J, Robinson M. Zero- vs. one-dimensional, parametric vs. non-parametric, and confidence interval vs. hypothesis testing procedures in one-dimensional biomechanical trajectory analysis. J Biomech. 2015;48:1277-85 pubmed publisher
    ..was to demonstrate that a parametric equivalent to the 1D bootstrap exists in the form of a random field theory (RFT) correction for multiple comparisons...
  43. Pataky T, Vanrenterghem J, Robinson M. The probability of false positives in zero-dimensional analyses of one-dimensional kinematic, force and EMG trajectories. J Biomech. 2016;49:1468-1476 pubmed publisher
    ..We first used random field theory (RFT) to predict the probability of false positives in 0D analyses...
  44. Repič Slavič T, Gostečnik C. Relational Family Therapy as an Aid Toward Resolving the Trauma of Sexual Abuse in Childhood in the Process of Separation in the Couple Relationship. J Marital Fam Ther. 2017;43:422-434 pubmed publisher
    Relational family therapy (RFT) is a psycho-organic therapeutic approach that combines intrapsychic dynamics with interpersonal mechanisms and a systemic perspective...
  45. Beyer K, Blasi F, Bacchelli E, Klauck S, Maestrini E, Poustka A. Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Hum Genet. 2002;111:305-9 pubmed
    ..Therefore, infantile autism and Rett syndrome probably represent two distinct entities at the molecular genetic level. ..
  46. Wang L, Lee K, Malonis R, SANCHEZ I, Dynlacht B. Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. elife. 2016;5: pubmed publisher
    To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites...
  47. Fujita N, Takebayashi S, Okumura K, Kudo S, Chiba T, Saya H, et al. Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. Mol Cell Biol. 1999;19:6415-26 pubmed
    ..To investigate the mechanisms underlying gene inactivation by DNA methylation, we characterized a human MBD1 protein, one of the components of MeCP1, which possesses a methyl-CpG binding domain (MBD) and cysteine-rich (CXXC) ..
  48. Duman E, Yildirim M, Kaya V, Ozturk D, Inal A, Akarsu Z, et al. Effects of Definitive Chemoradiotherapy on Respiratory Function Tests and Quality of Life Scores During Treatment of Lung Cancer. Asian Pac J Cancer Prev. 2015;16:6779-82 pubmed
    ..of Cancer (EORTC) were employed to evaluate the quality of life on the same day as respiratory function tests (RFT). The study included 23 patients in total: 19 (82.6%) diagnosed with NSCLC and 4 (17.4%) with SCLC...
  49. Wijenayake S, Storey K. The role of DNA methylation during anoxia tolerance in a freshwater turtle (Trachemys scripta elegans). J Comp Physiol B. 2016;186:333-42 pubmed publisher
    ..activity of four DNA methyltransferases (DNMT1, DNMT2, DNMT3a and DNMT3b), two methyl-binding domain proteins (MBD1 and MBD2), and relative genomic levels of 5-methylcytosine under control, 5 h anoxic, and 20 h anoxic conditions in ..
  50. Heimer B, Tam B, SIKES H. Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis. Protein Eng Des Sel. 2015;28:543-51 pubmed publisher
    ..We displayed three of the core members MBD1, MBD2 and MBD4 on the surface of Saccharomyces cerevisiae cells...
  51. Rathi M, Pinto B, Dhooria A, Sagar V, Mittal T, Rajan R, et al. Impact of renal involvement on survival in ANCA-associated vasculitis. Int Urol Nephrol. 2016;48:1477-82 pubmed publisher
    ..Patients were classified as advanced renal failure (creatinine >5.7 mg/dl or requiring dialysis), deranged RFT not qualifying the above parameters, and normal renal function. Sixty-seven (72.8 %) patients had GPA, 14 (15...
  52. Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, et al. DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J Biol Chem. 2017;292:1351-1360 pubmed publisher
    ..Here we demonstrate that the centrosome protein Dzip1 mediates the assembly of the BBSome-Dzip1-PCM1 complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome...
  53. Chen X, Li Y, He R, Ding Q. Phenotyping field-state wheat root system architecture for root foraging traits in response to environment×management interactions. Sci Rep. 2018;8:2642 pubmed publisher
    ..A 2-yr field experiment was conducted and the field-state wheat RSA was phenotyped for root foraging trait (RFT). Four RSA-derived traits, i.e...
  54. Nunes S, Ferralli J, Choi K, Brown Luedi M, Minet A, Chiquet Ehrismann R. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. Exp Cell Res. 2005;305:122-32 pubmed
    ..The second interacting protein identified is the methyl-CpG binding protein MBD1. In the nucleus, the intracellular domain of teneurin-1 colocalizes with this transcriptional repressor in foci ..
  55. Akamatsu F, Saleh S, Hojaij F, Martinez C, Andrade M, Teodoro W, et al. Radiofrequency preserves histoarchitecture and enhances collagen synthesis in experimental tendon injury. Histol Histopathol. 2016;31:515-22 pubmed publisher
    ..The right tendon was treated with radiofrequency (RFT), whereas the left tendon served as a control (CT)...
  56. Zhao J, Wang J, Hua W, Ouyang P. Algorithm, applications and evaluation for protein comparison by Ramanujan Fourier transform. Mol Cell Probes. 2015;29:396-407 pubmed publisher
    ..In this paper, we present Ramanujan Fourier transform (RFT) with a fast algorithm to analyze the low-frequency signals of protein sequences...
  57. Hayes S. Acceptance and Commitment Therapy, Relational Frame Theory, and the Third Wave of Behavioral and Cognitive Therapies - Republished Article. Behav Ther. 2016;47:869-885 pubmed publisher
    ..and is based on a basic experimental analysis of human language and cognition, Relational Frame Theory (RFT). RFT explains why cognitive fusion and experiential avoidance are both ubiquitous and harmful...
  58. Regina Silva S, Feres A, França Silva J, Dias E, Michalsky Ã, de Andrade H, et al. Field randomized trial to evaluate the efficacy of the Leish-Tec® vaccine against canine visceral leishmaniasis in an endemic area of Brazil. Vaccine. 2016;34:2233-9 pubmed publisher
    ..Here, Leish-Tec(®) efficacy was estimated through a randomized field trial (RFT), in a highly VL endemic area...
  59. Richardson G. Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover. J Vis Exp. 2016;: pubmed publisher
    ..as a result of DNA replication and cardiomyocyte nuclei identified by utilizing nuclei isolation and subsequent PCM1 immunolabeling...
  60. Liu H, Gu F, Dong S, Liu W, Wang H, Chen Z, et al. CONSTANS-like 9 (COL9) delays the flowering time in Oryza sativa by repressing the Ehd1 pathway. Biochem Biophys Res Commun. 2016;479:173-178 pubmed publisher
    ..flowering time under both short-day (SD) and long-day (LD) conditions, leading to suppressed expressions of EHd1, RFT and Hd3a at the mRNA Level...
  61. Ma J, Guan X, Guo R, Gan Z, Xie Y. Mechanism of non-appearance of hiatus in Tibetan Plateau. Sci Rep. 2017;7:4421 pubmed publisher
    ..divide the surface air temperature into dynamically-induced temperature (DIT) and radiatively-forced temperature (RFT) by applying the dynamical adjustment method...
  62. Hasan M, Hassan N, Khan R, Kim Y, Iqbal S. Classification of cancer cells using computational analysis of dynamic morphology. Comput Methods Programs Biomed. 2018;156:105-112 pubmed publisher
    ..Three different classifier models, Support Vector Machine (SVM), Random Forest Tree (RFT), and Naïve Bayes Classifier (NBC) were trained with the known dataset using machine learning algorithms...
  63. Chen S, Liao D, Shen T, Yang H, Chen K, Chen C. Genetic signatures of heroin addiction. Medicine (Baltimore). 2016;95:e4473 pubmed publisher
    ..measured the transcript level of 13 genes (RASA1, PRKCB, PDK1, JUN, CEBPG, CD74, CEBPB, AUTS2, ENO2, IMPDH2, HAT1, MBD1, and RGS3) in lymphoblastoid cell lines in a sample of 124 male heroin addicts and 124 male control subjects using ..
  64. Kumar R, Arioz C, Li Y, Bosaeus N, Rocha S, Wittung Stafshede P. Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics. Biometals. 2017;30:27-35 pubmed publisher
    ..in vitro and in silico, the biophysical consequences of clinically-observed Wilson disease mutations, G85V in MBD1 and G591D in MBD6, incorporated in domain 4...
  65. Verse T, Wenzel S, Brus J. Multi-level surgery for obstructive sleep apnea. Lingual tonsillectomy vs. hyoid suspension in combination with radiofrequency of the tongue base. Sleep Breath. 2015;19:1361-6 pubmed publisher
    ..underwent a hyoid suspension type 2 (HS) in combination with a radiofrequency treatment of the base of the tongue (RFT TB). In addition, all patients underwent an uvulopalatopharyngoplasty with tonsillectomy...
  66. Coutinho C, Mercadante M, Jorge A, Paz C, El Faro L, Monteiro F. Growth curves of carcass traits obtained by ultrasonography in three lines of Nellore cattle selected for body weight. Genet Mol Res. 2015;14:14076-87 pubmed publisher
    ..Body weight (BW), hip height (HH), rib eye area (REA), back fat thickness (BFT), and rump fat thickness (RFT) were measured and records collected from animals 8 to 20 (males) and 11 to 26 (females) months of age...
  67. Zhao J, Fan Y, Chen L, Gao S, Li F, Wang K. Alteration of methyl-CpG binding domain family in patients with chronic hepatitis B. Clin Res Hepatol Gastroenterol. 2017;41:272-283 pubmed publisher
    ..The mRNA levels of MeCP2, MBD1, MBD2 and MBD4 were upregulated in patients with CHB compared with HCs...
  68. de Lima F, Martins I, Faria A, Calhau C, Azevedo J, Fernandes I, et al. Influence of rye flour enzymatic biotransformation on the antioxidant capacity and transepithelial transport of phenolic acids. Food Funct. 2018;9:1889-1898 pubmed publisher
    ..Vanillic and sinapic acids in tannase-treated whole rye flour (RFT) were higher than RF after in vitro gastrointestinal digestion, and higher amounts of transported vanillic acid ..
  69. Hwang I, Oh E, Kim D, Oh C. Multiple plasmid-borne virulence genes of Clavibacter michiganensis ssp. capsici critical for disease development in pepper. New Phytol. 2017;: pubmed publisher
    ..The C. michiganensis ssp. capsici type strain PF008 carries one chromosome (3.056 Mb) and two plasmids (39 kb pCM1Cmc and 145 kb pCM2Cmc )...
  70. Cross S, Meehan R, Nan X, Bird A. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet. 1997;16:256-9 pubmed
    ..HRX is related to Drosophila trithorax. The protein, known as Protein Containing MBD (PCM1), was expressed in bacteria and shown to bind specifically to methylated DNA...
  71. Liu C, Chen Y, Yu X, Jin C, Xu J, Long J, et al. Proteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference. BMC Cancer. 2008;8:121 pubmed publisher
    Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in human pancreatic carcinomas...
  72. Xie B, Yu Y, Meng X, Yu Q, Shi J, Sang H, et al. Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios. Psychiatr Genet. 2014;24:221-4 pubmed publisher
    ..Four tag SNPs on MBD1 (rs125555, rs140689, rs140687, and rs140686), three tag SNPs on MBD2 (rs3876254, rs7614, and rs1145317), and three ..
  73. Zhang B, Xu J, Li C, Shi S, Ji S, Xu W, et al. MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Curr Mol Med. 2016;16:404-11 pubmed
    b>MBD1 (Methyl-CpG Binding Domain Protein 1) is highly expressed in pancreatic cancer...
  74. Alonso Alvarez B, Pérez González L. Contextual control over equivalence and nonequivalence explains apparent arbitrary applicable relational responding in accordance with sameness and opposition. Learn Behav. 2017;45:228-242 pubmed publisher
    ..responding (AARR) in accordance with the frames of sameness and opposition, as defined in relational frame theory (RFT)...
  75. Saito M, Ishikawa F. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem. 2002;277:35434-9 pubmed
    ..It was therefore suggested that mCpG-binding-defective MBD3 has evolutionarily conserved its MBD because of the secondary role played by the MBD in protein-protein interactions. ..
  76. Mendonca A, Sánchez O, Liu W, Li Z, Yuan C. CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes. Biochim Biophys Acta Gene Regul Mech. 2017;1860:713-720 pubmed publisher
    The methyl-binding domain of MBD1 is a common methyl CpG binding motif and has been linked to transcriptional repression...
  77. Zhang P, Rausch C, Hastert F, Boneva B, Filatova A, Patil S, et al. Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Res. 2017;45:7118-7136 pubmed publisher
    ..demonstrate that increased Tet1 heterochromatin localization and 5-methylcytosine oxidation are dependent on the CXXC3 domain of Mbd1, which recognizes unmethylated CpG dinucleotides...
  78. Yu C, Yang N, Bothe J, Tonelli M, Nokhrin S, Dolgova N, et al. The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics. J Biol Chem. 2017;292:18169-18177 pubmed publisher
    ..the copper chaperone Atox1, which delivers copper to ATP7B, and the group of the first three metal-binding domains (MBD1-3) are central to the activity regulation of ATP7B...
  79. Oberley M, Denton C, Ji J, Hiemenz M, Bhojwani D, Ostrow D, et al. A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia. Cancer Genet. 2017;216-217:91-99 pubmed publisher
    ..group called "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 or with PCM1-JAK2"...
  80. Carney R, Wolpert C, Ravan S, Shahbazian M, Ashley Koch A, Cuccaro M, et al. Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr Neurol. 2003;28:205-11 pubmed
    ..These data provide additional evidence of variable expression in the Rett disorder phenotype and suggest MeCP2 testing may be warranted for females presenting with autistic disorder. ..
  81. Villa R, Morey L, Raker V, Buschbeck M, Gutierrez A, De Santis F, et al. The methyl-CpG binding protein MBD1 is required for PML-RARalpha function. Proc Natl Acad Sci U S A. 2006;103:1400-5 pubmed
    ..Here we report that MBD1, a member of a conserved family of proteins able to bind methylated DNA, cooperates with PML-RARalpha in ..
  82. Zuo S, Zou S, Luo J, Guo W, Xu L, Dong J, et al. Effect of antisense MBD1 gene eukaryotic expression plasmid on expression of MBD1 gene in human biliary tract carcinoma cells. J Huazhong Univ Sci Technolog Med Sci. 2005;25:658-61 pubmed
    ..In order to provide a research tool for the study on the function of MBD1 gene in DNA methylation and tumorigenesis, antisense MBD1 gene eukaryotic expression plasmid was constructed and ..
  83. Adkins N, Georgel P. MeCP2: structure and function. Biochem Cell Biol. 2011;89:1-11 pubmed publisher
    ..We specifically focused on MeCP2's role in Rett syndrome, a neurological disorder associated with specific MeCP2 mutations. ..
  84. Varshney D, Vavrova Anderson J, Oler A, Cowling V, Cairns B, White R. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation. Nat Commun. 2015;6:6569 pubmed publisher
    ..The data suggest that methylation of histones rather than DNA plays a dominant role in suppressing SINE transcription. ..
  85. Gimpel P, Lee Y, Sobota R, Calvi A, Koullourou V, Patel R, et al. Nesprin-1?-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells. Curr Biol. 2017;27:2999-3009.e9 pubmed publisher
    ..The relocalization of centrosomal proteins, including Pericentrin, Pcm1, and ?-tubulin, depends on Nesprin-1, an outer nuclear membrane (ONM) protein that connects the nucleus to the ..
  86. Ohki I, Shimotake N, Fujita N, Nakao M, Shirakawa M. Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1. EMBO J. 1999;18:6653-61 pubmed
    ..We have determined the solution structure of the MBD of the human methylation-dependent transcriptional repressor MBD1 by multi-dimensional heteronuclear NMR spectroscopy...
  87. Lyst M, Nan X, Stancheva I. Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins. EMBO J. 2006;25:5317-28 pubmed
    ..b>MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at ..
  88. Yaqinuddin A, Abbas F, Naqvi S, Bashir M, Qazi R, Qureshi S. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes. Biosci Rep. 2008;28:319-26 pubmed publisher
    ..To determine whether the two well characterized proteins MeCP2 (methyl-CpG-binding protein 2) and MBD1 (methyl-CpG-binding domain 1) have distinct or redundant functions, we employed RNAi (RNA interference) to silence ..
  89. Ueba T, Kaspar B, Zhao X, Gage F. Repression of human fibroblast growth factor 2 by a novel transcription factor. J Biol Chem. 1999;274:10382-7 pubmed
    Here we describe the cloning of the regulator of fibroblast growth factor 2 (FGF-2) transcription (RFT) using a yeast one-hybrid screening with a defined motif in FGF-2 promoter as a target sequence...
  90. Ohki I, Shimotake N, Fujita N, Jee J, Ikegami T, Nakao M, et al. Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell. 2001;105:487-97 pubmed
    ..We report here the solution structure of the MBD of the human methylation-dependent transcriptional regulator MBD1 bound to methylated DNA. DNA binding causes a loop in MBD1 to fold into a major and novel DNA binding interface...
  91. Crowther Swanepoel D, Broderick P, Di Bernardo M, Dobbins S, Torres M, Mansouri M, et al. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat Genet. 2010;42:132-6 pubmed publisher
    ..2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy...
  92. Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, et al. Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Int J Oncol. 2013;42:2046-52 pubmed publisher
    ..Methyl-CpG binding domain protein 1 (MBD1), which plays an important role in disease progression, contributes to the drug resistance of PC cells; however, ..