Max

Summary

Gene Symbol: Max
Description: MYC associated factor X
Alias: bHLHd4, protein max, class D basic helix-loop-helix protein 4
Species: human
Products:     Max

Top Publications

  1. Ayer D, Kretzner L, Eisenman R. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 1993;72:211-22 pubmed
    ..proteins appear to function through heterodimerization with the stable, constitutively expressed bHLH-Zip protein, Max. To determine whether Max mediates the function of regulatory proteins other than Myc, we screened a lambda gt11 ..
  2. McMahon S, Van Buskirk H, Dugan K, Copeland T, Cole M. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. 1998;94:363-74 pubmed
    ..These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways. ..
  3. Grandori C, Cowley S, James L, Eisenman R. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol. 2000;16:653-99 pubmed
    The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression...
  4. Nair S, Burley S. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell. 2003;112:193-205 pubmed
    X-ray structures of the basic/helix-loop-helix/leucine zipper (bHLHZ) domains of Myc-Max and Mad-Max heterodimers bound to their common DNA target (Enhancer or E box hexanucleotide, 5'-CACGTG-3') have been determined at 1.9 A and 2...
  5. Ferré D Amaré A, Prendergast G, Ziff E, Burley S. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature. 1993;363:38-45 pubmed
    The three-dimensional structure of the basic/helix-loop-helix/leucine zipper domain of the transcription factor Max complexed with DNA has been determined by X-ray crystallography at 2.9 A resolution...
  6. Brownlie P, Ceska T, Lamers M, Romier C, Stier G, Teo H, et al. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. Structure. 1997;5:509-20 pubmed
    b>Max belongs to the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors...
  7. Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, et al. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?. Oncogene. 2000;19:3266-77 pubmed
    ..encode central regulators of mammalian cell proliferation and apoptosis, and they associate with the bHLHZip protein Max to bind specific DNA sequences and regulate the expression of genes important for cell cycle progression...
  8. Burnichon N, Cascon A, Schiavi F, Morales N, Comino Mendez I, Abermil N, et al. MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma. Clin Cancer Res. 2012;18:2828-37 pubmed publisher
    ..Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X), which predisposes carriers to PCC...
  9. Blackwood E, Eisenman R. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991;251:1211-7 pubmed
    ..region of c-Myc was used to screen a complementary DNA (cDNA) expression library, and a bHLH-Zip protein, termed Max, was identified...

More Information

Publications120 found, 100 shown here

  1. Zervos A, Gyuris J, Brent R. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell. 1993;72:223-32 pubmed
    We used the interaction trap to isolate a novel human protein that specifically interacts with Max. This protein, Mxi1 (for Max interactor 1), contains a bHLH-Zip motif that is similar to that found in Myc family proteins...
  2. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J. 1997;16:2892-906 pubmed
    ..leucine zipper domain (bHLHZip) and bind DNA at the E box (CANNTG) consensus by forming heterodimers with Max. We report the isolation, characterization and mapping of a human gene and its mouse homolog encoding a new member ..
  3. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol. 2001;3:392-9 pubmed
    ..Myc and Max form a complex with Miz-1 at the p15 initiator and inhibit transcriptional activation by Miz-1...
  4. Luscher B. Function and regulation of the transcription factors of the Myc/Max/Mad network. Gene. 2001;277:1-14 pubmed
    The members of the Myc/Max/Mad network function as transcriptional regulators...
  5. Grinberg A, Hu C, Kerppola T. Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Mol Cell Biol. 2004;24:4294-308 pubmed
    ..We have visualized the subcellular locations of complexes formed by Myc/Max/Mad family proteins using bimolecular fluorescence complementation (BiFC) analysis...
  6. Zhang K, Faiola F, Martinez E. Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun. 2005;336:274-80 pubmed
    The c-Myc oncoprotein (Myc) functions as a transcription regulator in association with an obligatory partner, Max, to control cell growth and differentiation...
  7. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, et al. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol. 2005;25:10220-34 pubmed
    ..oncoprotein (Myc) controls cell fate by regulating gene transcription in association with a DNA-binding partner, Max. While Max lacks a transcription regulatory domain, the N terminus of Myc contains a transcription activation ..
  8. Comino Mendez I, Gracia Aznárez F, Schiavi F, Landa I, Leandro García L, Leton R, et al. Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. Nat Genet. 2011;43:663-7 pubmed publisher
    ..We sequenced the exomes of three unrelated individuals with hereditary PCC (cases) and identified mutations in MAX, the MYC associated factor X gene...
  9. Hurlin P, Queva C, Koskinen P, Steingrimsson E, Ayer D, Copeland N, et al. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995;14:5646-59 pubmed
    The basic helix-loop-helix-leucine zipper (bHLHZip) protein Max associates with members of the Myc family, as well as with the related proteins Mad (Mad1) and Mxi1...
  10. Dietz B, Hajirahimkhan A, Dunlap T, Bolton J. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev. 2016;68:1026-1073 pubmed
    ..Plant extracts with estrogenic activities for menopausal symptom relief include Glycine max (soy), Trifolium pratense (red clover), Pueraria lobata (kudzu), Humulus lupulus (hops), Glycyrrhiza species (..
  11. Hayashi S, Akao N, Okamoto K. Meningeal plasma cell granuloma in the early stage of relapsing polychondritis. Rinsho Shinkeigaku. 2017;57:280-286 pubmed publisher
    ..sup>18F-fluorodeoxyglucose positron emission tomography showed increased uptake in the left frontal region (Max SUV: 7.54)...
  12. Oh A, Sohn S, Lee J, Park J, Nam K, Hahm K, et al. ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome. Metabolism. 2018;85:286-297 pubmed publisher
    ..Ectopic co-expression of ChREBP and its heterodimer partner Max-like protein X activated the Glut5 promoter in Caco-2BBE cells...
  13. Kandimalla R, Dash S, Bhowal A, Kalita S, Talukdar N, Kundu S, et al. Glycogen-gold nanohybrid escalates the potency of silymarin. Int J Nanomedicine. 2017;12:7025-7038 pubmed publisher
    ..Significant higher plasma Cmax supported the enhanced bioavailability of Sly upon GSGNPs treatment compared to SGNPs and free Sly...
  14. Raffetto J, Qiao X, Beauregard K, Khalil R. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010;51:972-81 pubmed publisher
    ..Phenylephrine caused concentration-dependent contraction that was less in female (max 104.2 +/- 16.2) than male IVC (172.4 +/- 20.4). AngII (10(-6))-induced contraction was also less in female (81...
  15. Sankar P, Zachariah B, Vickneshwaran V, Jacob S, Sridhar M. Amelioration of oxidative stress and insulin resistance by soy isoflavones (from Glycine max) in ovariectomized Wistar rats fed with high fat diet: the molecular mechanisms. Exp Gerontol. 2015;63:67-75 pubmed publisher
  16. Kosová K, Vítámvás P, Urban M, Klíma M, Roy A, Prášil I. Biological Networks Underlying Abiotic Stress Tolerance in Temperate Crops--A Proteomic Perspective. Int J Mol Sci. 2015;16:20913-42 pubmed publisher
    ..durum), barley (Hordeum vulgare), maize (Zea mays); leguminous plants: alfalfa (Medicago sativa), soybean (Glycine max), common bean (Phaseolus vulgaris), pea (Pisum sativum); oilseed rape (Brassica napus); potato (Solanum tuberosum); ..
  17. Loganathan S, Korkmaz Icöz S, Radovits T, Li S, Mikles B, Barnucz E, et al. Effects of soluble guanylate cyclase activation on heart transplantation in a rat model. J Heart Lung Transplant. 2015;34:1346-53 pubmed publisher
    ..05), dP/dt(max) (1,703 ± 162 mm Hg vs 3,350 ± 444 mm Hg, p < 0...
  18. Mehta R, Ponnuchamy M, Kumar J, Reddy N. Exploring drought stress-regulated genes in senna (Cassia angustifolia Vahl.): a transcriptomic approach. Funct Integr Genomics. 2017;17:1-25 pubmed publisher
    ..Senna transcriptome showed the highest similarity to Glycine max (41 %), followed by Phaseolus vulgaris (16 %), Cicer arietinum (15 %), and Medicago trancatula (5 %)...
  19. Khadir A, Kavalakatt S, Abubaker J, Cherian P, Madhu D, Al Khairi I, et al. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone. Metabolism. 2016;65:1409-20 pubmed publisher
    ..protein were found in obese compared to lean subjects which correlated negatively with maximum oxygen uptake (VO2 Max) but positively with high-sensitivity C-reactive protein (hsCRP) and obesity indicators such as BMI, percentage ..
  20. Mauhin W, Habarou F, Gobin S, Servais A, Brassier A, Grisel C, et al. Update on Lysinuric Protein Intolerance, a Multi-faceted Disease Retrospective cohort analysis from birth to adulthood. Orphanet J Rare Dis. 2017;12:3 pubmed publisher
    ..4 years (min-max: 0.4-37.0 years)...
  21. Yang Q, Cao Y. [Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:501-505 pubmed publisher
    ..end-diastolic pressure (LVEDP), the maximal rate of increase/decrease in left ventricular pressure (±dp/dt max)], the ratio of the heart weight/body weight, and the ratio of the left ventricular weight/heart weight (LVW/HW), ..
  22. Zhang H, Liu H, Chen Y, Zhang Y. The Curcumin-Induced Vasorelaxation in Rat Superior Mesenteric Arteries. Ann Vasc Surg. 2018;48:233-240 pubmed publisher
    ..The Emax value refers to the maximum relaxation...
  23. de Souza P, de Souza K, de Assis C, de Araújo M, Silva K, de Fátima Xavier da Silva J, et al. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquat Toxicol. 2018;197:109-121 pubmed publisher
    ..32?±?0.20?mM for gills and 0.43?±?0.12?mM for viscera. The Vmax values for gills and viscera were 53.57?±?1.72 and 27.71?±?1.15?mU/mg, respectively...
  24. Brijs J, Jutfelt F, Clark T, Gräns A, Ekström A, Sandblom E. Experimental manipulations of tissue oxygen supply do not affect warming tolerance of European perch. J Exp Biol. 2015;218:2448-54 pubmed publisher
    ..we investigated the effects of oxygen transport capacity on aerobic scope and the critical thermal maximum (CT(max))...
  25. Cheng C, Zhang X, Meng Y, Zhang Z, Chen J, Zhang Q. Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties. Soft Matter. 2017;13:3003-3012 pubmed publisher
    ..Water contact angles and swelling studies suggested that the hydrogels could swell in water, with a max swell ratio of 1559%, and pH and temperature had an influence on the equilibrium swelling ratio...
  26. Xu M, Yamagishi N, Zhao C, Takeshima R, Kasai M, Watanabe S, et al. The Soybean-Specific Maturity Gene E1 Family of Floral Repressors Controls Night-Break Responses through Down-Regulation of FLOWERING LOCUS T Orthologs. Plant Physiol. 2015;168:1735-46 pubmed publisher
    ..To reveal the molecular basis of photoperiodism in soybean (Glycine max), a facultative short-day plant, we analyzed the transcriptional profiles of the maturity gene E1 family and two ..
  27. Liu J, Qin W, Wu H, Yang C, Deng J, Iqbal N, et al. Metabolism variation and better storability of dark- versus light-coloured soybean (Glycine max L. Merr.) seeds. Food Chem. 2017;223:104-113 pubmed publisher
    ..It was concluded that there are certain metabolic regularities that are associated with different coloured seed coats of soybeans under storage conditions. ..
  28. Kanagasabai T, Chaput J. Sleep duration and the associated cardiometabolic risk scores in adults. Sleep Health. 2017;3:195-203 pubmed publisher
    ..WC) were stratified by sex first, while fasting insulin, fasting plasma glucose (Glu), triglycerides (TG), body max index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were standardized without ..
  29. Arrieta O, García Pérez F, Michel Tello D, Ramírez Tirado L, Pitalua Cortes Q, Cruz Rico G, et al. Response Assessment of 68Ga-DOTA-E-[c(RGDfK)]2 PET/CT in Lung Adenocarcinoma Patients Treated with Nintedanib Plus Docetaxel. J Nucl Med. 2018;59:403-409 pubmed publisher
    ..PET/CT correlated with serum vascular endothelial growth factor levels, whereas baseline lung/liver SUVmax index correlated with platelet-derived growth factor AB...
  30. Zhang L, Lu X, Wang J, Li P, Li H, Wei S, et al. Zingiberis rhizoma mediated enhancement of the pharmacological effect of aconiti lateralis radix praeparata against acute heart failure and the underlying biological mechanisms. Biomed Pharmacother. 2017;96:246-255 pubmed publisher
    ..g., heart rate (HR) and the maximal rising and declining rate of left ventricle pressure (±dp/dtmax)] and serum indicators [e.g...
  31. Grut H, Dueland S, Line P, Revheim M. The prognostic value of 18F-FDG PET/CT prior to liver transplantation for nonresectable colorectal liver metastases. Eur J Nucl Med Mol Imaging. 2018;45:218-225 pubmed publisher
    ..Maximum, mean and peak standardized uptake values (SUVmax, SUVmean and SUVpeak), tumor to background (T/B) ratio, metabolic tumor volume (MTV) ..
  32. Lv Z, Yang Y, Wang J, Chen J, Li J, Di L. Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide Liposomes by Response Surface Methodology and Study of Their Blood Brain Barrier Permeability. Molecules. 2018;23: pubmed publisher
    ..The pharmacokinetic parameters of GGB-LP were significantly improved too, with Tmax of 15 min and a high drug concentration of 3.39 ?g/g in brain...
  33. Vemula S. A Novel Approach to Flurbiprofen Pulsatile Colonic Release: Formulation and Pharmacokinetics of Double-Compression-Coated Mini-Tablets. AAPS PharmSciTech. 2015;16:1465-73 pubmed publisher
    ..86. From the pharmacokinetic evaluation, core mini-tablets producing peak plasma concentration (C max) was 14,677.51 ± 12.16 ng/ml at 3 h T max and pulsatile colonic tablets showed C max = 12,374.67 ± 16...
  34. Huang F, Zhang J, Wang H, Zhai F, Zhang B. [Pre-packaged foods' nutritional ingredients analysis among 706 adult residents in cities in China]. Zhonghua Yu Fang Yi Xue Za Zhi. 2015;49:152-5 pubmed
    ..871 kinds of pre-packaged foods were collected. The median (min, max) of energy contents of puffed foods, baked foods and leisure foods were 2 155(1 638-2 785) kJ/100 g, 1 980 (582-2 ..
  35. Koch R, Rich W. Stink Bug (Hemiptera: Heteroptera: Pentatomidae) Feeding and Phenology on Early-Maturing Soybean in Minnesota. J Econ Entomol. 2015;108:2335-43 pubmed publisher
    ..by Halyomorpha halys (Stål) and an increasing abundance of native Pentatomidae pose a threat to soybean, Glycine max (L.) Merrill, production in northern states...
  36. Costa J, Rodriguez J, Alba J, Rivadulla I, Perez del Molino M, Aguilera A. [Prevalence and distribution of hepatitis B virus genotype D in Galicia (northwest of Spain): influence of age, sex and origin]. Rev Esp Quimioter. 2016;29:269-72 pubmed
    ..positive, HBV DNA-positive, partial HBV-DNA S gene was amplified, sequenced and analysed using geno2pheno (hbv) (Max-Planck Institute) on line application. We found 259 (64...
  37. Lin Y, Lee R, Guo W, Chu W, Wu F, Gehrisch S. Quantitative Real-Time Fluoroscopy Analysis on Measurement of the Hepatic Arterial Flow During Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma: Comparison with Quantitative Digital Subtraction Angiography Analysis. Cardiovasc Intervent Radiol. 2016;39:1557-1563 pubmed publisher
    ..d-QCA and f-QCA were used for determining the relative maximal density time (rTmax) of the selected arteries...
  38. Fletcher G, Eves F, Glover E, Robinson S, Vernooij C, Thompson J, et al. Dietary intake is independently associated with the maximal capacity for fat oxidation during exercise. Am J Clin Nutr. 2017;105:864-872 pubmed publisher
    ..b>Design: The MFO and maximal oxygen uptake ([Formula: see text]O2 max) were determined with the use of indirect calorimetry in 305 healthy volunteers [150 men and 155 women; mean ± SD ..
  39. Fayon M, Lacoste Rodrigues A, Barat P, Helbling J, Nacka F, Berger P, et al. Nasal airway epithelial cell IL-6 and FKBP51 gene expression and steroid sensitivity in asthmatic children. PLoS ONE. 2017;12:e0177051 pubmed publisher
    ..6 patients without asthma (median age 11yr; min-max: 7-13), 8 with controlled asthma (11yr, 7-13; median daily fluticasone dose = 100 ?g), and 4 with uncontrolled ..
  40. Briqué Pellet C, Ravinet N, Quenet Y, Alvinerie M, Chartier C. Pharmacokinetics and anthelmintic efficacy of injectable eprinomectin in goats. Vet Parasitol. 2017;241:43-47 pubmed publisher
    ..The maximal plasma concentrations (Cmax) were 20.68±12.85 vs 39.79±17.25?g/L and the plasma bioavailabilities (AUC) 83.45±34.75 vs 169.37±43...
  41. Sindhu R, Manonmani H. Expression and characterization of recombinant l-asparaginase from Pseudomonas fluorescens. Protein Expr Purif. 2018;143:83-91 pubmed publisher
    ..The purified l-asparaginase had a specific activity of 26 U/mg with a Km and Vmax of 0.050 M and 4.032 mol-1min...
  42. El Barky A, Hussein S, Alm Eldeen A, Hafez Y, Mohamed T. Anti-diabetic activity of Holothuria thomasi saponin. Biomed Pharmacother. 2016;84:1472-1487 pubmed publisher
    ..The UV spectra revealed that ?max of saponin extract was 282nm which in accordance to the standard saponin...
  43. Souza R, Ambrósio E, Souza M, Freitas T, Ferrari Lima A, Garcia J. Solar photocatalytic degradation of textile effluent with TiO2, ZnO, and Nb2O5 catalysts: assessment of photocatalytic activity and mineralization. Environ Sci Pollut Res Int. 2017;24:12691-12699 pubmed publisher
    ..TiO2 reduced the absorbance at 660 nm (?max) after 300 min of solar irradiation around 94 and 93%; and 68 and 60% of COD, respectively...
  44. El Bassossy H, Ghaleb H, Elberry A, Balamash K, Ghareib S, Azhar A, et al. Geraniol alleviates diabetic cardiac complications: Effect on cardiac ischemia and oxidative stress. Biomed Pharmacother. 2017;88:1025-1030 pubmed publisher
    ..systolic function associated with diabetes as indicated by inhibiting the decrease in the rate of rise (dP/dtmax) in ventricular pressure and the increase in systolic duration observed in diabetic rats...
  45. Muturi A, Ndaguatha P, Ojuka D, Kibet A. Prevalence and predictors of intra-abdominal hypertension and compartment syndrome in surgical patients in critical care units at Kenyatta National Hospital. BMC Emerg Med. 2017;17:10 pubmed publisher
    ..Of our study population, 71.7% (by IAP max) and 67.3% (by IAP mean) had IAH. Abdominal compartment syndrome (ACS) developed in 4.4% of the population...
  46. Hu J, Zhang J, Chen Y, Liang W, Wu S. In Vitro Anaerobic Pharmacokinetic/Pharmacodynamic Model to Simulate the Bactericidal Activity of Levornidazole Against Bacteroides fragilis. Clin Ther. 2017;39:828-836 pubmed publisher
    ..Sigmoid Emax model of levornidazole was established to calculate PK/PD target values to attain corresponding PD effect...
  47. Wheat W, Arthun E, Spencer J, Regan D, Titus R, Dow S. Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model. Vaccine. 2017;35:6611-6619 pubmed publisher
    ..longipalpis sand fly salivary component maxadilan (MAX) as antigen (Ag), we show that mice are protected from the MAX-induced exacerbation of infection with Leishmania ..
  48. Marie P, Plissonnier D, Bravetti S, Coscas R, Rouer M, Haulon S, et al. Low baseline and subsequent higher aortic abdominal aneurysm FDG uptake are associated with poor sac shrinkage post endovascular repair. Eur J Nucl Med Mol Imaging. 2018;45:549-557 pubmed publisher
    ..69?±?0.33), but markedly increased at 6 months (2.42?±?0.69, p?=?0.02 vs. baseline). These SUV max values were by contrast much higher at baseline in the 3rd tercile (SUVmax: 2.53?±?0.83 p?=?0.009 vs...
  49. Sandhu D, Pudussery M, Kaundal R, Suarez D, Kaundal A, Sekhon R. Molecular characterization and expression analysis of the Na+/H+ exchanger gene family in Medicago truncatula. Funct Integr Genomics. 2018;18:141-153 pubmed publisher
    ..Phylogenetic analysis involving A. thaliana, Glycine max, Phaseolus vulgaris, and M...
  50. Storch Jakobsen A, Speyer H, Nørgaard H, Hjorthøj C, Krogh J, Mors O, et al. Associations between clinical and psychosocial factors and metabolic and cardiovascular risk factors in overweight patients with schizophrenia spectrum disorders - Baseline and two-years findings from the CHANGE trial. Schizophr Res. 2018;: pubmed publisher
    ..cardiovascular risk factors: Dependent variables were baseline and follow-up values of the following: VO2max, waist circumference, high density lipoprotein (HDL), systolic blood pressure and HbA1c...
  51. Paavolainen L, HAkkinen K, Hämäläinen I, Nummela A, Rusko H. Explosive-strength training improves 5-km running time by improving running economy and muscle power. J Appl Physiol (1985). 1999;86:1527-33 pubmed
    ..treadmill running tests were used to determine maximal velocity in the MART (VMART) and maximal oxygen uptake (VO2 max). The 5K time, RE, and VMART improved (P < 0.05) in E, but no changes were observed in C...
  52. Hatt M, Cheze le Rest C, Aboagye E, Kenny L, Rosso L, Turkheimer F, et al. Reproducibility of 18F-FDG and 3'-deoxy-3'-18F-fluorothymidine PET tumor volume measurements. J Nucl Med. 2010;51:1368-76 pubmed publisher
    ..volume (TGV), and total proliferative volume (TPV)-relative to those of maximum standardized uptake value (SUV(max)), commonly used in clinical practice...
  53. Carapeta S, do Bem B, McGuinness J, Esteves A, Abecasis A, Lopes Ã, et al. Negeviruses found in multiple species of mosquitoes from southern Portugal: Isolation, genetic diversity, and replication in insect cell culture. Virology. 2015;483:318-28 pubmed publisher
    ..Phylogenetic analysis of two products encoded by the viral ORF1 placed both viruses among Negev virus cluster, in the recently proposed Nelorpivirus taxon. ..
  54. Prince S, Joshi T, Mutava R, Syed N, Joao Vitor M, Patil G, et al. Comparative analysis of the drought-responsive transcriptome in soybean lines contrasting for canopy wilting. Plant Sci. 2015;240:65-78 pubmed publisher
    Drought stress causes significant yield losses in major oil seed crops, such as soybean [Glycine max (L.) Merr]...
  55. Li Y, Arakawa G, Tokuda G, Watanabe H, Arioka M. Heterologous expression in Pichia pastoris and characterization of a ?-glucosidase from the xylophagous cockroach Panesthia angustipennis spadica displaying high specific activity for cellobiose. Enzyme Microb Technol. 2017;97:104-113 pubmed publisher
    ..3±1.1mM), PaBG1b demonstrated high specific activity and catalytic efficiency towards cellobiose with Vmax and kcat/Km values of 436.7±6.3U/mg and 109...
  56. Pang X, Wang Y, Chen Y. Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2017;27:2803-2806 pubmed publisher
    ..In rats, N-trideuteromethyl compound 19 displayed 1.8-fold peak concentration (Cmax), and nearly doubled its drug exposure in plasma (AUC0-?) compared to compound 18...
  57. Kits A, Martin H, Sanchez Crespo A, Delgado A. Diagnostic accuracy of 11C-methionine PET in detecting neuropathologically confirmed recurrent brain tumor after radiation therapy. Ann Nucl Med. 2018;32:132-141 pubmed publisher
    ..The area under the ROC curve (AUC) was 0.89 for SURmaxmirror and 0.88 for SURmaxcortex. The mean (SD) of SURmaxmirror was 2.37 (0...
  58. Musther H, Gill K, Chetty M, Rostami Hodjegan A, Rowland M, Jamei M. Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site. AAPS J. 2015;17:1268-79 pubmed publisher
    Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (C(max)) following intravenous administration...
  59. Byeon Y, Choi G, Lee H, Back K. Melatonin biosynthesis requires N-acetylserotonin methyltransferase activity of caffeic acid O-methyltransferase in rice. J Exp Bot. 2015;66:6917-25 pubmed publisher
    ..The K m and V max values for the ASMT activity of OsCOMT were 243 µM and 2400 pmol min(-1) mg protein(-1), which were similar to ..
  60. O Hearn K, Tingelstad H, Blondin D, Tang V, Filion L, Haman F. Heat exposure increases circulating fatty acids but not lipid oxidation at rest and during exercise. J Therm Biol. 2016;55:39-46 pubmed publisher
    ..passively heated for 120 min at 42 °C, then exercised on a treadmill in the same temperature at 50% V̇O2 max for 30 min (HEAT). This same procedure was followed on a separate occasion at 23 °C (CON)...
  61. García J, Sedran U, Zaini M, Zakaria Z. Preparation, characterization, and dye removal study of activated carbon prepared from palm kernel shell. Environ Sci Pollut Res Int. 2018;25:5076-5085 pubmed publisher
    ..and carbonized at 550 °C showed the highest MB adsorption capacity (maximum uptake at the equilibrium, q max = 225...
  62. Wang L, Kazmierczak K, Yuan C, Yadav S, Kawai M, Szczesna Cordary D. Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice. FEBS J. 2017;284:1897-1913 pubmed publisher
    ..5-month-old mice by echocardiography and invasive hemodynamics, demonstrated a significant decrease in dP/dtmax -end-diastolic volume relationship, indicating a depression of ventricular contractility in N47K mice...
  63. Toumi K, Joly L, Vleminckx C, Schiffers B. Risk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing Bouquets. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..gloves were worn during two consecutive half days while handling flowers and preparing bouquets (from min 2 h to max 3 h/day)...
  64. Wu H, Ma C, Ran J, Xu D, Liu A, Sun M, et al. Biomechanical research on contour cage with transacetabular screws fixation in revision total hip arthroplasty. Clin Biomech (Bristol, Avon). 2017;47:117-122 pubmed publisher
    ..However, the max strain in root part of the flange will be reduced using transacetabular screws in ilium, pubis and ischium together,..
  65. Pin Barre C, Constans A, Brisswalter J, Pellegrino C, Laurin J. Effects of High- Versus Moderate-Intensity Training on Neuroplasticity and Functional Recovery After Focal Ischemia. Stroke. 2017;48:2855-2864 pubmed publisher
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    ..These mutations also differentially affected BCRP ATPase activities with a 2- to 4-fold increase in V(max)/K(m) for K452A and H457A and a 40 to 70% decrease for K453D and R465A...
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    ..Serum marbofloxacin content was determined by high-performance liquid chromatography. We estimated the Cmax (6.28 ?g/ml), AUC0-24 h (60.30 ?g.h/ml), AUC0-? (88.94 ?g.h/ml), T1/2ke, (12...
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    ..The hemodynamic parameters of heart rate (HR), left ventricular end systolic pressure [LVESP], +dp/dtmax, and -dp/dtmax were recorded...
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    ..documentation, as differences between values obtained from the object and those given in the design project (max. ± 20 cm for situation and ±5 cm for elevation) were within the range defined by the legislator...
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    ..It also showed high oral absorption in mice (the maximum drug concentration (Cmax)=45.5?µM at 30?mg/kg), rats (Cmax=53.6?µM at 30?mg/kg), and beagles (Cmax=37...
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    ..CIs) of the geometric mean ratios (GMRs) for ticagrelor and AR-C124910XX maximum plasma concentration (C max) and area under the plasma concentration-time curve (AUC) were within the acceptance interval (80%-125%) for ..
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    Maximal heart rate (HRmax) is a fundamental measure used in exercise prescription. The Apple Watch™ measures heart rate yet the validity and inter-device variability of the device for measuring HRmax are unknown...
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    ..The ratios of required evaporative capacity to maximal evaporative capacity of the environment (E(req)/E(max)) for CD, HD, and HH were approximately 1.2, 1.6, and 2.5, respectively...
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    ..in intramyocellular lipid stores (IMCL) from baseline after a 2-h treadmill run [67% of maximal oxygen uptake (VO2 max)] and the recovery of IMCL in response to a postexercise very low-fat (10% of energy, LFAT) or moderate-fat (35% of ..
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    ..The maximum sorption capacities Q max (at 50 °C) obtained with the modified pozzolan were 350.6 and 300...
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    ..The mean and maximal relative cerebral blood volume (rCBV) ratio (rCBVmean and rCBVmax), derived from MR perfusion weighted imaging, of the enhancing tumor, as well as maximal rCBV ratio of peri-..
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    ..addition, performance in 6-min walk test (MWT), aerobic capacity assessed from maximal oxygen uptake (VO2max), and the metabolic equivalent of task (MET) were evaluated...
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    ..minimal, if any, firing rate modulation of early recruited motor units during slow contractions (< or =1% EMG(max)/s), and later recruited motor units consistently presented higher peak firing rates...