maspin

Summary

Gene Symbol: maspin
Description: serpin family B member 5
Alias: PI5, maspin, serpin B5, PI-5, peptidase inhibitor 5, protease inhibitor 5 (maspin), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serpin peptidase inhibitor, clade B (ovalbumin), member 5
Species: human
Products:     maspin

Top Publications

  1. Sharma G, Mirza S, Parshad R, Srivastava A, Gupta S, Pandya P, et al. Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression. Tumour Biol. 2011;32:23-32 pubmed publisher
    b>Maspin is a serine protease inhibitor with tumor-suppressor activity. Maspin can suppress tumor growth and metastasis in vivo and tumor cell motility and invasion in vitro...
  2. Bailey C, Khalkhali Ellis Z, Kondo S, Margaryan N, Seftor R, Wheaton W, et al. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. J Biol Chem. 2005;280:34210-7 pubmed
    Since its reported discovery in 1994, maspin (mammary serine protease inhibitor) has been characterized as a class II tumor suppressor by its ability to promote apoptosis and inhibit cell invasion...
  3. Ngamkitidechakul C, Warejcka D, Burke J, O Brien W, Twining S. Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule. J Biol Chem. 2003;278:31796-806 pubmed
    b>Maspin, an ov-serpin, inhibits tumor invasion and induces cell adhesion to extracellular matrix molecules...
  4. Pemberton P, Wong D, Gibson H, Kiefer M, Fitzpatrick P, Sager R, et al. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. J Biol Chem. 1995;270:15832-7 pubmed
    ..b>Maspin is a tumor suppressor produced by a number of cell types of epithelial origin...
  5. Wu Y, Alvarez M, Slamon D, Koeffler P, Vadgama J. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010;10:32 pubmed publisher
    ..sequencing were used for determination of proapoptotic gene Caspase 8 (CASP8) and the tumor suppressor gene maspin promoter methylation in four breast cancer and two non-tumorigenic breast cell lines...
  6. Frey A, Soubani A, Adam A, Sheng S, Pass H, Lonardo F. Nuclear, compared with combined nuclear and cytoplasmic expression of maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in Stage I, improved survival. Histopathology. 2009;54:590-7 pubmed publisher
    To evaluate whether there is a correlation between the subcellular localization of maspin and the histological, molecular and biological features of pulmonary adenocarcinoma, particularly addressing the hypothesis that the tumour ..
  7. Futscher B, O Meara M, Kim C, Rennels M, Lu D, Gruman L, et al. Aberrant methylation of the maspin promoter is an early event in human breast cancer. Neoplasia. 2004;6:380-9 pubmed
    The maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression...
  8. Chim S, Tong Y, Chiu R, Lau T, Leung T, Chan L, et al. Detection of the placental epigenetic signature of the maspin gene in maternal plasma. Proc Natl Acad Sci U S A. 2005;102:14753-8 pubmed
    ..By using bisulfite DNA sequencing, the methylation status of the maspin gene promoter in placental tissues and paired maternal blood cells from pregnant women was analyzed...
  9. Sato N, Fukushima N, Matsubayashi H, Goggins M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene. 2004;23:1531-8 pubmed
    ..A subset of eight genes were selected for further methylation analysis, and two cancer-related genes, maspin and S100P, were found to be aberrantly hypomethylated in a large fraction of pancreatic cancer cell lines and ..

More Information

Publications71

  1. Lockett J, Yin S, Li X, Meng Y, Sheng S. Tumor suppressive maspin and epithelial homeostasis. J Cell Biochem. 2006;97:651-60 pubmed
    b>Maspin is a 42-kDa novel serine protease inhibitor (serpin) with multifaceted tumor suppressive activities...
  2. Khalkhali Ellis Z. Maspin: the new frontier. Clin Cancer Res. 2006;12:7279-83 pubmed
    b>Maspin (mammary serine protease inhibitor) was identified in 1994 by subtractive hybridization analysis of normal mammary tissue and breast cancer cell lines...
  3. Kashima K, Ohike N, Mukai S, Sato M, Takahashi M, Morohoshi T. Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas. Hepatobiliary Pancreat Dis Int. 2008;7:86-90 pubmed
    b>Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis...
  4. Bolat F, Gumurdulu D, Erkanli S, Kayaselcuk F, Zeren H, Ali Vardar M, et al. Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma. Pathol Res Pract. 2008;204:379-87 pubmed publisher
    ..b>Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits motility, ..
  5. Hall D, Johnson Pais T, Grubbs B, Bernal R, Leach R, Padalecki S. Maspin reduces prostate cancer metastasis to bone. Urol Oncol. 2008;26:652-8 pubmed publisher
    b>Maspin is a serine protease inhibitor with anti-tumor activity, including inhibition of tumor growth, angiogenesis, invasion, motility, and metastasis. Normal mammary and prostate cells express maspin at high levels...
  6. Zheng H, Saito H, Masuda S, Wang Z, Takano Y. Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays. Appl Immunohistochem Mol Morphol. 2008;16:459-65 pubmed publisher
    b>Maspin, a serine protease inhibitor related to the serpin family, can inhibit invasion and metastasis of malignancies although direct evidence of the clinicopathologic significance of cytoplasmic relative to nuclear expression is limited...
  7. Santer F, Malinowska K, Culig Z, Cavarretta I. Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr Relat Cancer. 2010;17:241-53 pubmed publisher
    ..Finally, by western analyses, we uncovered an IL-6- and sIL-6R-dependent downregulation of the tumour suppressor maspin. Collectively, these data suggest that selective targeting of IL-6TS might allow to refine the currently available ..
  8. Yu M, Zheng H, Tsuneyama K, Takahashi H, Nomoto K, Xu H, et al. Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression. Hum Pathol. 2007;38:1248-55 pubmed
    b>Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies...
  9. Lonardo F, Li X, Kaplun A, Soubani A, Sethi S, Gadgeel S, et al. The natural tumor suppressor protein maspin and potential application in non small cell lung cancer. Curr Pharm Des. 2010;16:1877-81 pubmed
    ..distinct correlations between the expression and/or subcellular localization of tumor suppressive maspin with the progression and prognosis of NSCLC...
  10. Hong S, Lee J, Choe W, Ha H, Park K, Sung I, et al. The effect of aberrant maspin expression on the invasive ability of pancreatic ductal adenocarcinoma cells. Oncol Rep. 2009;21:425-30 pubmed
    b>Maspin is expressed aberrantly in pancreatic ductal adenocarcinoma (PDAC), and its function is still unknown...
  11. Yin S, Li X, Meng Y, Finley R, Sakr W, Yang H, et al. Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. J Biol Chem. 2005;280:34985-96 pubmed
    b>Maspin, a novel serine protease inhibitor, suppresses tumor progression in several cancer models, including an in vivo model for prostate cancer bone metastasis...
  12. Fung C, Chan C, Jankova L, Dent O, Robertson G, Molloy M, et al. Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer. Histopathology. 2010;56:319-30 pubmed publisher
    The tumour suppressor maspin has been investigated for its association with conventional histopathological features in colorectal cancer and for its potential as an independent predictor of survival and response to adjuvant chemotherapy...
  13. Ito R, Nakayama H, Yoshida K, Oda N, Yasui W. Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality. Oncol Rep. 2004;12:985-90 pubmed
    b>Maspin, a serine protease inhibitor related to the serpin family, was originally identified in normal mammary epithelium. Reduced expression of maspin is related with development, invasion and metastasis of certain human cancers...
  14. Sheng S. The promise and challenge toward the clinical application of maspin in cancer. Front Biosci. 2004;9:2733-45 pubmed
    Since the identification of the human maspin gene, a decade of extensive research revealed the promise of maspin both as a valuable molecular marker for the diagnosis and prognosis of many types of cancers, and as a tumor suppressor at ..
  15. Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma. Thyroid. 2004;14:13-8 pubmed
    b>Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits cell motility, invasion, and angiogenesis...
  16. Biliran H, Sheng S. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. Cancer Res. 2001;61:8676-82 pubmed
    b>Maspin is a novel serine protease inhibitor with tumor suppressive activity, inhibiting tumor invasion and metastasis. To date, the underlying molecular mechanism of maspin remains elusive...
  17. Jiang N, Meng Y, Zhang S, Mensah Osman E, Sheng S. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene. 2002;21:4089-98 pubmed
    b>Maspin, a novel serine protease inhibitor (serpin), suppresses the growth and metastasis of breast tumor in vivo. However, the underlying molecular mechanism is unclear...
  18. Ohike N, Maass N, Mundhenke C, Biallek M, Zhang M, Jonat W, et al. Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. Cancer Lett. 2003;199:193-200 pubmed
    We evaluated the biological relevance of maspin expression in pancreatic ductal adenocarcinoma and studied regulatory mechanisms of maspin gene activation in pancreatic carcinoma cell lines...
  19. Bieche I, Girault I, Sabourin J, Tozlu S, Driouch K, Vidaud M, et al. Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas. Br J Cancer. 2003;88:863-70 pubmed
    b>Maspin, a member of the serpin family, has a role in cell migration, angiogenesis and apoptosis. Little is known of the clinical significance of maspin gene expression in human cancers...
  20. Li Z, Shi H, Zhang M. Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis. Oncogene. 2005;24:2008-19 pubmed
    ..Targeting tumor vessel endothelium therefore should serve as an effective therapy for cancers. Maspin is a serpin that exhibits antiangiogenic properties...
  21. Zou Z, Anisowicz A, Hendrix M, Thor A, Neveu M, Sheng S, et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science. 1994;263:526-9 pubmed
    ..The gene product, called maspin, is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines...
  22. Märkl B, Arnholdt H, Jähnig H, Schenkirsch G, Herrmann R, Haude K, et al. Shift from cytoplasmic to nuclear maspin expression correlates with shorter overall survival in node-negative colorectal cancer. Hum Pathol. 2010;41:1024-33 pubmed publisher
    b>Maspin has been characterized as a potent tumor suppressor in many in vitro and in vivo studies...
  23. Xia W, Lau Y, Hu M, Li L, Johnston D, Sheng S, et al. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. Oncogene. 2000;19:2398-403 pubmed
    b>Maspin, a member of the serpin family of protease inhibitors, is known to have tumor-suppressor functions. However, the association between its expression level and survival has not been demonstrated in human cancer...
  24. Li X, Kaplun A, Lonardo F, Heath E, Sarkar F, Irish J, et al. HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells. Mol Cancer Res. 2011;9:733-45 pubmed publisher
    Both maspin and glutathione S-transferase pi (GSTp) are implicated as tumor suppressors and downregulated in human prostate cancer. It is well established that GSTp downregulation is through DNA methylation-based silencing...
  25. Umekita Y, Yoshida H. Expression of maspin is up-regulated during the progression of mammary ductal carcinoma. Histopathology. 2003;42:541-5 pubmed
    The tumour suppressor gene maspin is reported to inhibit the motility, invasiveness and metastasis of breast cancer cells...
  26. Latha K, Zhang W, Cella N, Shi H, Zhang M. Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol. 2005;25:1737-48 pubmed
    b>Maspin is a unique serpin with the ability to suppress certain types of malignant tumors. It is one of the few p53-targeted genes involved in tumor invasion and metastasis...
  27. Umekita Y, Souda M, Yoshida H. Expression of maspin in colorectal cancer. In Vivo. 2006;20:797-800 pubmed
    b>Maspin, a member of the serpin family of protease inhibitors, is known to be a tumor suppressor...
  28. Fitzgerald M, Oshiro M, Holtan N, Krager K, Cullen J, Futscher B, et al. Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia. 2003;5:427-36 pubmed
    The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis...
  29. Shi H, Stafford L, Liu Z, Liu M, Zhang M. Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase. Cell Motil Cytoskeleton. 2007;64:338-46 pubmed
    ..Here, we show that maspin, a well-documented tumor suppressor gene, also controls cell motility through inhibiting Rac1/Cdc42 activity...
  30. Dokras A, Coffin J, Field L, Frakes A, Lee H, Madan A, et al. Epigenetic regulation of maspin expression in the human placenta. Mol Hum Reprod. 2006;12:611-7 pubmed
    b>Maspin, a tumour suppressor gene, is differentially expressed in the human placenta...
  31. Li X, Yin S, Meng Y, Sakr W, Sheng S. Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin. Cancer Res. 2006;66:9323-9 pubmed
    b>Maspin, a noninhibitory serine protease inhibitor, exerts multifaceted tumor-suppressive effects. Maspin expression is associated with better differentiated phenotypes, better cancer prognosis, and better drug sensitivity...
  32. Jang H, Nam E, Lee K, Yeom S, Son H, Park C. Maspin polymorphism associated with apoptosis susceptibility and in vivo tumorigenesis. Int J Mol Med. 2008;22:333-8 pubmed
    b>Maspin is a tumor suppressor protein that stimulates apoptosis and inhibits motility, invasion and cancer metastasis. We report on a previously uncharacterized Pro/Ser (C to T) polymorphism at amino acid 176 of the human maspin protein...
  33. Pemberton P, Tipton A, Pavloff N, Smith J, Erickson J, Mouchabeck Z, et al. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J Histochem Cytochem. 1997;45:1697-706 pubmed
    The tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor cells progress from the benign to the invasive and metastatic states...
  34. Zhang W, Shi H, Zhang M. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. BMC Cancer. 2005;5:50 pubmed
    b>Maspin is a member of serpin family with tumor suppressing activity. Recent studies of maspin in animal models strongly support maspin's role as an inhibitor against the growth of primary tumor sand the process of metastasis...
  35. Tahmatzopoulos A, Sheng S, Kyprianou N. Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis. Oncogene. 2005;24:5375-83 pubmed
    b>Maspin is a mammary serine protease inhibitor or serpin with tumor suppressive and antiangiogenic activity that inhibits tumor motility, invasion and metastasis, at least by its actions on cell membrane and extracellular matrix (ECM) ..
  36. Yoshizawa K, Nozaki S, Okamune A, Kitahara H, Ohara T, Kato K, et al. Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma. J Oral Pathol Med. 2009;38:535-9 pubmed publisher
    b>Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function...
  37. Dokras A, Gardner L, Kirschmann D, Seftor E, Hendrix M. The tumour suppressor gene maspin is differentially regulated in cytotrophoblasts during human placental development. Placenta. 2002;23:274-80 pubmed
    ..The aims of this study were to determine whether the tumour suppressor gene maspin is present in the human placenta and plays a putative role in the regulation of cytotrophoblast invasion during ..
  38. Goulet B, Kennette W, Ablack A, Postenka C, Hague M, Mymryk J, et al. Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest. 2011;91:1181-7 pubmed publisher
    b>Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial...
  39. Sood A, Fletcher M, Gruman L, Coffin J, Jabbari S, Khalkhali Ellis Z, et al. The paradoxical expression of maspin in ovarian carcinoma. Clin Cancer Res. 2002;8:2924-32 pubmed
    b>Maspin is a noninhibitory member of the serpin family that is down-regulated in breast carcinoma but overexpressed in pancreatic carcinoma...
  40. Bass R, Fernández A, Ellis V. Maspin inhibits cell migration in the absence of protease inhibitory activity. J Biol Chem. 2002;277:46845-8 pubmed
    b>Maspin is a member of the serpin family of protease inhibitors and is a tumor suppressor gene acting at the level of tumor invasion and metastasis...
  41. Oshiro M, Watts G, Wozniak R, Junk D, Munoz Rodriguez J, Domann F, et al. Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression. Oncogene. 2003;22:3624-34 pubmed
    ..Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant ..
  42. Odero Marah V, Khalkhali Ellis Z, Schneider G, Seftor E, Seftor R, Koland J, et al. Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells. Biochem Biophys Res Commun. 2002;295:800-5 pubmed
    b>Maspin is a 42kDa tumor suppressor protein that belongs to the serine protease inhibitor (serpin) family...
  43. Stark A, Schem C, Maass N, Hugo H, Jonat W, Mehdorn H, et al. Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status. Neurol Res. 2010;32:303-8 pubmed publisher
    The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment...
  44. Alameda J, Gaspar M, Ramirez A, Navarro M, Page A, Suárez Cabrera C, et al. Deciphering the role of nuclear and cytoplasmic IKK? in skin cancer. Oncotarget. 2016;7:29531-47 pubmed publisher
    ..EGFR, MMP-9 and VEGF-A activities in tumors, nuclear IKK? causes tumor progression through regulation of c-Myc, Maspin and Integrin-?6 expression...
  45. Lu M, Li J, Huang Z, Du Y, Jin S, Wang J. Aberrant Maspin mRNA Expression is Associated with Clinical Outcome in Patients with Pulmonary Adenocarcinoma. Med Sci Monit. 2016;22:134-9 pubmed
    The aim of this study was to investigate the expression level of maspin mRNA in pulmonary adenocarcinoma and to clarify its clinical significance in prediction of prognosis...
  46. Li X, Chen D, Yin S, Meng Y, Yang H, Landis Piwowar K, et al. Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells. J Cell Physiol. 2007;212:298-306 pubmed
    Proteasome inhibitors are known to induce apoptosis in a variety of cancer cells. On the other hand, maspin, a non-inhibitory serine protease inhibitor, is shown to sensitize cancer cells to therapeutic agents that induce apoptosis...
  47. Choy B, Findeis Hosey J, Li F, McMahon L, Yang Q, Xu H. High frequency of coexpression of maspin with p63 and p53 in squamous cell carcinoma but not in adenocarcinoma of the lung. Int J Clin Exp Pathol. 2013;6:2542-7 pubmed
    b>Maspin, a member of the serpin family of protease inhibitors, has been shown to inhibit tumor growth and suppress metastasis in several malignancies, including lung cancer...
  48. Webber B, Lawson D, Cohen C. Maspin and Mutant p53 expression in malignant melanoma and carcinoma: use of tissue microarray. Appl Immunohistochem Mol Morphol. 2008;16:19-23 pubmed
    b>Maspin (mammary serine protease inhibitor), a member of the serpin family, has been shown to inhibit angiogenesis, tumor invasion, and metastasis. Previous studies suggest a p53-dependent regulatory pathway of maspin protein expression...
  49. McKenzie S, Sakamoto S, Kyprianou N. Maspin modulates prostate cancer cell apoptotic and angiogenic response to hypoxia via targeting AKT. Oncogene. 2008;27:7171-9 pubmed publisher
    ..This study investigated the effect of maspin, an extracellular matrix (ECM) tumor suppressor, on the apoptotic response of prostate cancer cells to hypoxia...
  50. Zhou J, Hualong Q, Zhou P, Guo F. Different maspin functions in the lung adenocarcinoma A549 and SPC-A1 cell lines. Int J Mol Med. 2015;36:1440-8 pubmed publisher
    Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is silenced in the majority of cancer cells during metastatic progression by transcriptional and epigenetic mechanisms...
  51. Yamaguchi H, Ding Y, Lee J, Zhang M, Pal A, Bornmann W, et al. Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol Carcinog. 2008;47:739-43 pubmed publisher
    ..In the present study, we demonstrated that the metastasis suppressor maspin acts as the downstream target of IFIXalpha...
  52. Torres A, Torres K, Paszkowski T, Radej S, Staśkiewicz G, Ceccaroni M, et al. Highly increased maspin expression corresponds with up-regulation of miR-21 in endometrial cancer: a preliminary report. Int J Gynecol Cancer. 2011;21:8-14 pubmed publisher
    b>Maspin and programmed cell death 4 (Pdcd4) are tumor suppressor genes, and miR-21 is overexpressed in many solid tumors and was proven to negatively regulate a number of tumor suppressor genes including maspin and Pdcd4...
  53. Lee D, Park C, Kim H, Kim J, Kim Y, Lee S. Maspin and p53 protein expression in gastric adenocarcinoma and its clinical applications. Appl Immunohistochem Mol Morphol. 2008;16:13-8 pubmed
    To investigate the role of maspin and p53 expression in the progression of gastric cancer, and its value as a prognostic indicator...
  54. Lee S, Jang H, Park C. Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. Int J Mol Med. 2012;29:225-30 pubmed publisher
    ..The dissociation of Bax from Ku70 is essential for the apoptotic activity of Bax. Here, we show that maspin, a tumor suppressor protein frequently lost in cancer, regulates this process...
  55. Li H, Leung S, Chan C, Yu M, Wong Y. Expression of maspin in endometrioid adenocarcinoma of endometrium. Oncol Rep. 2007;17:393-8 pubmed
    b>Maspin is a member of the serpin family, whose expression is altered in neoplasia and malignancies of many tissues...
  56. Besgen P, Trommler P, Vollmer S, Prinz J. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. J Immunol. 2010;184:5392-402 pubmed publisher
    ..Common serologic reactivities of rabbits and patients included the proteins ezrin, maspin, peroxiredoxin 2 (PRDX2), heat shock protein (hsp)27, and keratin 6...
  57. Neal C, HENDERSON V, Smith B, McKeithen D, Graham T, Vo B, et al. Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells. BMC Cancer. 2012;12:336 pubmed publisher
    b>Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cell motility...
  58. Takeda C, Takagi Y, Shiomi T, Nosaka K, Yamashita H, Osaki M, et al. Cytoplasmic maspin expression predicts poor prognosis of patients with soft tissue sarcomas. Diagn Pathol. 2014;9:205 pubmed publisher
    b>Maspin is a 42 kDa protein known to act as a tumor suppressor. Although its function has not been fully elucidated, numerous reports have investigated the prognostic impact of maspin in patients with several types of cancer...
  59. Kim S, Kim H, Lee D, Kim K, Park S, Kim M, et al. Quantification of the placental epigenetic signature of the SERPINB5 gene in maternal plasma of pregnancies complicated by small for gestational age. Placenta. 2015;36:131-7 pubmed publisher
    ..Our findings suggest that U-SERPINB5 and M-SERPINB5 concentrations in maternal plasma during early pregnancy are not associated with pregnancies who delivered SGA neonates. ..
  60. Shi X, Liu H, Cao J, Liu Q, Tang G, Liu W, et al. Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation. PLoS ONE. 2015;10:e0135359 pubmed publisher
    ..Mammary Serine Protease Inhibitor (Maspin, SERPINB5) plays a putative role in regulating the invasive activity of cytotrophoblasts...
  61. Sun L, Li Y, Yang B. Downregulated long non-coding RNA MEG3 in breast cancer regulates proliferation, migration and invasion by depending on p53's transcriptional activity. Biochem Biophys Res Commun. 2016;478:323-329 pubmed publisher
    ..migration and invasion capacities by enhancing p53's transcriptional activity on its target genes, including p21, Maspin and KAI1...
  62. Zheng H, Gong B. The roles of maspin expression in gastric cancer: a meta- and bioinformatics analysis. Oncotarget. 2017;8:66476-66490 pubmed publisher
    b>Maspin is a mammary serine protease inhibitor that is encoded by human SERPINB5 gene, and inhibits invasion and metastasis of cancer cells as a tumor suppressor...