maspin

Summary

Gene Symbol: maspin
Description: serpin peptidase inhibitor, clade B (ovalbumin), member 5
Alias: PI5, maspin, PI-5, peptidase inhibitor 5, protease inhibitor 5 (maspin), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serpin B5
Species: human

Top Publications

  1. ncbi Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin
    Xiaohua Li
    Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Cancer Res 66:9323-9. 2006
  2. ncbi Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell Motil Cytoskeleton 64:338-46. 2007
  3. ncbi Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis
    Zhigang Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 24:2008-19. 2005
  4. pmc Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control
    Matthew Fitzgerald
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Neoplasia 5:427-36. 2003
  5. ncbi Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells
    Valerie A Odero-Marah
    Department of Anatomy and Cell Biology, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Biochem Biophys Res Commun 295:800-5. 2002
  6. pmc Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 5:50. 2005
  7. doi Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis
    Brigitte Goulet
    London Regional Cancer Program, London, Ontario, Canada
    Lab Invest 91:1181-7. 2011
  8. pmc HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells
    Xiaohua Li
    Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Mol Cancer Res 9:733-45. 2011
  9. ncbi Expression of maspin is up-regulated during the progression of mammary ductal carcinoma
    Y Umekita
    Department of Pathology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Histopathology 42:541-5. 2003
  10. ncbi High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
    W Xia
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 19:2398-403. 2000

Detail Information

Publications187 found, 100 shown here

  1. ncbi Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin
    Xiaohua Li
    Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Cancer Res 66:9323-9. 2006
    b>Maspin, a noninhibitory serine protease inhibitor, exerts multifaceted tumor-suppressive effects. Maspin expression is associated with better differentiated phenotypes, better cancer prognosis, and better drug sensitivity...
  2. ncbi Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell Motil Cytoskeleton 64:338-46. 2007
    ..Here, we show that maspin, a well-documented tumor suppressor gene, also controls cell motility through inhibiting Rac1/Cdc42 activity...
  3. ncbi Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis
    Zhigang Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 24:2008-19. 2005
    ..Targeting tumor vessel endothelium therefore should serve as an effective therapy for cancers. Maspin is a serpin that exhibits antiangiogenic properties...
  4. pmc Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control
    Matthew Fitzgerald
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Neoplasia 5:427-36. 2003
    The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis...
  5. ncbi Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells
    Valerie A Odero-Marah
    Department of Anatomy and Cell Biology, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Biochem Biophys Res Commun 295:800-5. 2002
    b>Maspin is a 42kDa tumor suppressor protein that belongs to the serine protease inhibitor (serpin) family...
  6. pmc Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 5:50. 2005
    b>Maspin is a member of serpin family with tumor suppressing activity. Recent studies of maspin in animal models strongly support maspin's role as an inhibitor against the growth of primary tumor sand the process of metastasis...
  7. doi Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis
    Brigitte Goulet
    London Regional Cancer Program, London, Ontario, Canada
    Lab Invest 91:1181-7. 2011
    b>Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial...
  8. pmc HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells
    Xiaohua Li
    Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Mol Cancer Res 9:733-45. 2011
    Both maspin and glutathione S-transferase pi (GSTp) are implicated as tumor suppressors and downregulated in human prostate cancer. It is well established that GSTp downregulation is through DNA methylation-based silencing...
  9. ncbi Expression of maspin is up-regulated during the progression of mammary ductal carcinoma
    Y Umekita
    Department of Pathology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Histopathology 42:541-5. 2003
    The tumour suppressor gene maspin is reported to inhibit the motility, invasiveness and metastasis of breast cancer cells...
  10. ncbi High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
    W Xia
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 19:2398-403. 2000
    b>Maspin, a member of the serpin family of protease inhibitors, is known to have tumor-suppressor functions. However, the association between its expression level and survival has not been demonstrated in human cancer...
  11. pmc A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene
    S S Schneider
    Department of Pediatrics, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:3147-51. 1995
    ..arrayed and flanked by two other closely related serpins, plasminogen activator inhibitor type 2 (PAI2) and maspin at 18q21.3. The genomic structure of the two genes, SCCA1 and SCCA2, was highly conserved...
  12. doi Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis
    Petra Besgen
    Department of Dermatology, Ludwig Maximilians University of Munich, Munich, Germany
    J Immunol 184:5392-402. 2010
    ..Common serologic reactivities of rabbits and patients included the proteins ezrin, maspin, peroxiredoxin 2 (PRDX2), heat shock protein (hsp)27, and keratin 6...
  13. ncbi Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression
    Marc M Oshiro
    Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Oncogene 22:3624-34. 2003
    ..Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant ..
  14. doi Shift from cytoplasmic to nuclear maspin expression correlates with shorter overall survival in node-negative colorectal cancer
    Bruno Märkl
    Institute of Pathology, Klinikum Augsburg, Augsburg 86156, Germany
    Hum Pathol 41:1024-33. 2010
    b>Maspin has been characterized as a potent tumor suppressor in many in vitro and in vivo studies...
  15. pmc Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
    ..Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer...
  16. ncbi Maspin polymorphism associated with apoptosis susceptibility and in vivo tumorigenesis
    Hye Lim Jang
    Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Int J Mol Med 22:333-8. 2008
    b>Maspin is a tumor suppressor protein that stimulates apoptosis and inhibits motility, invasion and cancer metastasis. We report on a previously uncharacterized Pro/Ser (C to T) polymorphism at amino acid 176 of the human maspin protein...
  17. doi Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma
    Kunio Yoshizawa
    Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Oral Pathol Med 38:535-9. 2009
    b>Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function...
  18. pmc Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
    Frédéric R Santer
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Endocr Relat Cancer 17:241-53. 2010
    ..Finally, by western analyses, we uncovered an IL-6- and sIL-6R-dependent downregulation of the tumour suppressor maspin. Collectively, these data suggest that selective targeting of IL-6TS might allow to refine the currently available ..
  19. pmc Nuclear, compared with combined nuclear and cytoplasmic expression of maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in Stage I, improved survival
    Amy Frey
    Department of Pathology, Harper University Hospital, Wayne State University, Detroit, MI 48201, USA
    Histopathology 54:590-7. 2009
    To evaluate whether there is a correlation between the subcellular localization of maspin and the histological, molecular and biological features of pulmonary adenocarcinoma, particularly addressing the hypothesis that the tumour ..
  20. doi Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status
    Andreas M Stark
    Department of Neurosurgery, University of Schleswig Holstein Medical Center, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Neurol Res 32:303-8. 2010
    The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment...
  21. pmc Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas
    I Bieche
    Laboratoire d oncogénétique, INSERM E0017, 35 rue Dailly, Centre Rene Huguenin, St Cloud, France
    Br J Cancer 88:863-70. 2003
    b>Maspin, a member of the serpin family, has a role in cell migration, angiogenesis and apoptosis. Little is known of the clinical significance of maspin gene expression in human cancers...
  22. ncbi Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule
    Chatri Ngamkitidechakul
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 278:31796-806. 2003
    b>Maspin, an ov-serpin, inhibits tumor invasion and induces cell adhesion to extracellular matrix molecules...
  23. ncbi Tumor suppressive maspin and epithelial homeostasis
    Jaron Lockett
    The Department of Pathology, Wayne State University School of Medicine and Karmonos Cancer Institute, Detroit, Michigan 48201, USA
    J Cell Biochem 97:651-60. 2006
    b>Maspin is a 42-kDa novel serine protease inhibitor (serpin) with multifaceted tumor suppressive activities...
  24. ncbi The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin
    P A Pemberton
    LXR Biotechnology, Richmond, California 94804, USA
    J Biol Chem 270:15832-7. 1995
    ..b>Maspin is a tumor suppressor produced by a number of cell types of epithelial origin...
  25. pmc Detection of the placental epigenetic signature of the maspin gene in maternal plasma
    Stephen S C Chim
    Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
    Proc Natl Acad Sci U S A 102:14753-8. 2005
    ..By using bisulfite DNA sequencing, the methylation status of the maspin gene promoter in placental tissues and paired maternal blood cells from pregnant women was analyzed...
  26. ncbi Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase
    Shuping Yin
    Department of Pathology, Center of Molecular Medicine and Genetics, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 280:34985-96. 2005
    b>Maspin, a novel serine protease inhibitor, suppresses tumor progression in several cancer models, including an in vivo model for prostate cancer bone metastasis...
  27. pmc Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership
    Caleb M Bailey
    Department of Anatomy and Cell Biology and Pediatrics, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USA
    J Biol Chem 280:34210-7. 2005
    Since its reported discovery in 1994, maspin (mammary serine protease inhibitor) has been characterized as a class II tumor suppressor by its ability to promote apoptosis and inhibit cell invasion...
  28. ncbi Epigenetic regulation of maspin expression in the human placenta
    Anuja Dokras
    Department of Obstetrics and Gynecology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA, USA
    Mol Hum Reprod 12:611-7. 2006
    b>Maspin, a tumour suppressor gene, is differentially expressed in the human placenta...
  29. pmc Maspin: the new frontier
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Clin Cancer Res 12:7279-83. 2006
    b>Maspin (mammary serine protease inhibitor) was identified in 1994 by subtractive hybridization analysis of normal mammary tissue and breast cancer cell lines...
  30. doi Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression
    Gayatri Sharma
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    Tumour Biol 32:23-32. 2011
    b>Maspin is a serine protease inhibitor with tumor-suppressor activity. Maspin can suppress tumor growth and metastasis in vivo and tumor cell motility and invasion in vitro...
  31. ncbi Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin
    H Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 61:8676-82. 2001
    b>Maspin is a novel serine protease inhibitor with tumor suppressive activity, inhibiting tumor invasion and metastasis. To date, the underlying molecular mechanism of maspin remains elusive...
  32. doi Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer
    Caroline L S Fung
    Department of Anatomical Pathology, Concord Hospital, and Discipline of Pathology, The University of Sydney, Sydney, New South Wales, Australia
    Histopathology 56:319-30. 2010
    The tumour suppressor maspin has been investigated for its association with conventional histopathological features in colorectal cancer and for its potential as an independent predictor of survival and response to adjuvant chemotherapy...
  33. ncbi The paradoxical expression of maspin in ovarian carcinoma
    Anil K Sood
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 8:2924-32. 2002
    b>Maspin is a noninhibitory member of the serpin family that is down-regulated in breast carcinoma but overexpressed in pancreatic carcinoma...
  34. ncbi Proteomics demonstration that normal breast epithelial cells can induce apoptosis of breast cancer cells through insulin-like growth factor-binding protein-3 and maspin
    Robert Alain Toillon
    INSERM ERI 8 JE 2488 Signalisation des facteurs de croissance dans le cancer du sein Protéomique fonctionnelle, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
    Mol Cell Proteomics 6:1239-47. 2007
    ..nano-LC-nano-ESI-MS/MS allowed the identification of insulin-like growth factor-binding protein-3 (IGFBP-3) and maspin as the proapoptotic factors produced by normal breast epithelial cells...
  35. pmc Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition
    Khatri Latha
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 25:1737-48. 2005
    b>Maspin is a unique serpin with the ability to suppress certain types of malignant tumors. It is one of the few p53-targeted genes involved in tumor invasion and metastasis...
  36. ncbi Maspin sensitizes breast carcinoma cells to induced apoptosis
    Ning Jiang
    Department of Pathology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan, MI 48201, USA
    Oncogene 21:4089-98. 2002
    b>Maspin, a novel serine protease inhibitor (serpin), suppresses the growth and metastasis of breast tumor in vivo. However, the underlying molecular mechanism is unclear...
  37. ncbi Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
    Z Zou
    Division of Cancer Genetics, Dana Farber Cancer Institute, Boston, MA 02115
    Science 263:526-9. 1994
    ..The gene product, called maspin, is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines...
  38. ncbi Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface
    P A Pemberton
    LXR Biotechnology, Inc, Richmond, California 94804, USA
    J Histochem Cytochem 45:1697-706. 1997
    The tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor cells progress from the benign to the invasive and metastatic states...
  39. ncbi Maspin inhibits cell migration in the absence of protease inhibitory activity
    Rosemary Bass
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 277:46845-8. 2002
    b>Maspin is a member of the serpin family of protease inhibitors and is a tumor suppressor gene acting at the level of tumor invasion and metastasis...
  40. doi Maspin reduces prostate cancer metastasis to bone
    Devon C Hall
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Urol Oncol 26:652-8. 2008
    b>Maspin is a serine protease inhibitor with anti-tumor activity, including inhibition of tumor growth, angiogenesis, invasion, motility, and metastasis. Normal mammary and prostate cells express maspin at high levels...
  41. ncbi Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
    Norihiro Sato
    1Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Oncogene 23:1531-8. 2004
    ..A subset of eight genes were selected for further methylation analysis, and two cancer-related genes, maspin and S100P, were found to be aberrantly hypomethylated in a large fraction of pancreatic cancer cell lines and ..
  42. ncbi Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
    We evaluated the biological relevance of maspin expression in pancreatic ductal adenocarcinoma and studied regulatory mechanisms of maspin gene activation in pancreatic carcinoma cell lines...
  43. ncbi Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Thyroid 14:13-8. 2004
    b>Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits cell motility, invasion, and angiogenesis...
  44. ncbi The promise and challenge toward the clinical application of maspin in cancer
    Shijie Sheng
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Front Biosci 9:2733-45. 2004
    Since the identification of the human maspin gene, a decade of extensive research revealed the promise of maspin both as a valuable molecular marker for the diagnosis and prognosis of many types of cancers, and as a tumor suppressor at ..
  45. ncbi The effect of aberrant maspin expression on the invasive ability of pancreatic ductal adenocarcinoma cells
    Sung Noh Hong
    Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea
    Oncol Rep 21:425-30. 2009
    b>Maspin is expressed aberrantly in pancreatic ductal adenocarcinoma (PDAC), and its function is still unknown...
  46. ncbi Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas
    Kyoko Kashima
    First Department of Pathology, Showa University School of Medicine, Tokyo, Japan
    Hepatobiliary Pancreat Dis Int 7:86-90. 2008
    b>Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis...
  47. ncbi Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression
    Miao Yu
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani, Toyama 2630, Japan
    Hum Pathol 38:1248-55. 2007
    b>Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies...
  48. doi Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma
    Filiz Bolat
    Baskent University Faculty of Medicine, Department of Pathology, Ankara, Turkey
    Pathol Res Pract 204:379-87. 2008
    ..b>Maspin belongs to the serpin superfamily and has been identified as a tumor suppressor because it inhibits motility, ..
  49. doi Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Appl Immunohistochem Mol Morphol 16:459-65. 2008
    b>Maspin, a serine protease inhibitor related to the serpin family, can inhibit invasion and metastasis of malignancies although direct evidence of the clinicopathologic significance of cytoplasmic relative to nuclear expression is limited...
  50. ncbi Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality
    Reiko Ito
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 12:985-90. 2004
    b>Maspin, a serine protease inhibitor related to the serpin family, was originally identified in normal mammary epithelium. Reduced expression of maspin is related with development, invasion and metastasis of certain human cancers...
  51. ncbi The tumour suppressor gene maspin is differentially regulated in cytotrophoblasts during human placental development
    A Dokras
    Department of Obstetrics and Gynecology and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Placenta 23:274-80. 2002
    ..The aims of this study were to determine whether the tumour suppressor gene maspin is present in the human placenta and plays a putative role in the regulation of cytotrophoblast invasion during ..
  52. pmc Aberrant methylation of the maspin promoter is an early event in human breast cancer
    Bernard W Futscher
    Bone Marrow Transplant Program, Arizona Cancer Center, and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 6:380-9. 2004
    The maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression...
  53. ncbi Expression of maspin in colorectal cancer
    Yoshihisa Umekita
    Department of Tumor Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    In Vivo 20:797-800. 2006
    b>Maspin, a member of the serpin family of protease inhibitors, is known to be a tumor suppressor...
  54. pmc Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis
    Anastasios Tahmatzopoulos
    Department of Surgery, Division of Urology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Oncogene 24:5375-83. 2005
    b>Maspin is a mammary serine protease inhibitor or serpin with tumor suppressive and antiangiogenic activity that inhibits tumor motility, invasion and metastasis, at least by its actions on cell membrane and extracellular matrix (ECM) ..
  55. ncbi Functional activity of eukaryotic signal sequences in Escherichia coli: the ovalbumin family of serine protease inhibitors
    D Belin
    Departement de Pathologie, Universite de Geneve, CH 1211 Geneva, Switzerland
    J Mol Biol 335:437-53. 2004
    ..the ovalbumin signal sequence is much more efficient, whereas the corresponding sequence elements from LEI, maspin and PI-10 are entirely devoid of signal sequence activity in E.coli...
  56. ncbi Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins
    J Sun
    Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Australia
    J Biol Chem 270:16089-96. 1995
    ..activator inhibitor-2, the squamous cell carcinoma antigen, monocyte/neutrophil elastase inhibitor, and maspin. Although these proteins are associated with carcinomas and inflammation, they appear to have diverse functions ..
  57. ncbi Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25
    F L Scott
    Department of Medicine, Monash University Medical School, Box Hill, 3128, Australia
    Genomics 62:490-9. 1999
    ..PCR analysis demonstrated that PI5 at 18q21 also lacks this exon, indicating that it is organized identically to the 6p25 genes...
  58. pmc The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates
    Charaf Benarafa
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:11367-72. 2005
    ..Orthologues of PAI-2 (SERPINB2), MNEI (SERPINB1), PI-6 (SERPINB6), and maspin (SERPINB5) are highly conserved...
  59. ncbi Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3
    A J Bartuski
    Joint Program in Neonatology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 43:321-8. 1997
    ..Recently, we mapped four members of the family [SCCA1, SCCA2, PAI2, and PI5 (maspin)] to a 300-kb region within 18q21.3. Using a panel of 18q21...
  60. ncbi Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen
    Pierre Corvol
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Curr Hypertens Rep 5:149-54. 2003
    ..Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, ..
  61. ncbi A role of novel serpin maspin in tumor progression: the divergence revealed through efforts to converge
    Shijie Sheng
    Department of Pathology, The Proteases and Cancer Program of the Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Cell Physiol 209:631-5. 2006
    b>Maspin, a 42 kDa protein, belongs to the serine protease inhibitor (serpin) superfamily and is more closely related to the ovalbumin-like serpin subfamily (ov-serpins)...
  62. pmc Maspin (SERPINB5) is an obligate intracellular serpin
    Sonia S Y Teoh
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia
    J Biol Chem 285:10862-9. 2010
    b>Maspin (SERPINB5) is a tumor suppressor lost in breast and prostate cancer whose molecular function is unknown...
  63. ncbi Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma
    Torahiko Nakashima
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Head Neck 28:24-30. 2006
    ..On chromosome 18q21, there is a cluster of serpins: maspin, headpin, and squamous cell carcinoma antigen 1 (SCCA1)/SCCA2...
  64. pmc Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin
    S Sheng
    Division of Cancer Genetics, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:499-504. 1998
    The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice...
  65. ncbi SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases
    Y S Askew
    Department of Pediatrics, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 276:49320-30. 2001
    ..The gene mapped to the ov-serpin cluster at 18q21 and resided between SERPINB5 (maspin) and SERPINB13 (headpin). The presence of SERPINB12 in silico was confirmed by cDNA cloning...
  66. ncbi 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation
    R J Wozniak
    Department of Pharmacology and Toxicology, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Oncogene 26:77-90. 2007
    ..Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer...
  67. ncbi Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma
    Manju L Prasad
    Department of Pathology, Ohio State University, Columbus, OH, USA
    Mod Pathol 21:105-14. 2008
    ..and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to ..
  68. ncbi [Expression of maspin protein and correlation between maspin and P53 proteins in gastric carcinoma]
    Yan He
    Department of Pathology, Harbin Medical University, Harbin 150081, China
    Zhonghua Yi Xue Za Zhi 87:909-12. 2007
    To study the expression of maspin protein and the correlation between maspin and P53 proteins in gastric carcinoma, so as to provide a new valid index for diagnosis of gastric carcinoma.
  69. pmc Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts
    Mark A Horswill
    Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Eye Res 86:586-600. 2008
    b>Maspin, a 42 kDa non-classical serpin (serine protease inhibitor) that controls cell migration and invasion, is mainly expressed by epithelial-derived cells but is also expressed in corneal stromal keratocytes...
  70. doi Is maspin immunolocalization a tool to differentiate central low-grade mucoepidermoid carcinoma from glandular odontogenic cyst?
    Marilena Vered
    Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Acta Histochem 112:161-8. 2010
    ..LGMEC shares a number of histopathological similarities with glandular odontogenic cysts (GOC) of the jawbones. Maspin has been identified in several benign and malignant salivary gland neoplasms...
  71. doi Possible involvement of maspin in tooth development
    Purevsuren Davaadorj
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Histochem Cell Biol 134:603-14. 2010
    b>Maspin is a 42 kDa serine protease inhibitor that possesses tumor suppressive and anti-angiogenic activities...
  72. doi Modulation of tumorigenesis and oestrogen receptor-alpha expression by cell culture conditions in a stem cell-derived breast epithelial cell line
    Kai Hung Wang
    Graduate Institute of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Biol Cell 102:159-72. 2010
    ..In the present study, we tested the hypothesis that deprivation of growth factors and hormones may change the tumorigenicity and oestrogen response of this cell line...
  73. ncbi Advances in salivary gland pathology
    W Cheuk
    Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong
    Histopathology 51:1-20. 2007
    ..CD117 can aid in highlighting the luminal cell component of various salivary gland tumours, whereas p63 or maspin can aid in highlighting the abluminal cell component...
  74. ncbi [The changes in chloroplast proteome caused by different nuclear background in cytoplasmic male-sterile (CMS) of wheat]
    Wei jia Zhang
    Department of Biology, Tianjin Normal University, Tianjin 300074
    Fen Zi Xi Bao Sheng Wu Xue Bao 40:84-90. 2007
    ..4/34kDa, pl5.4/32kDa) at seedling stage,6 protein spots (pl5.4/80kDa, pl5.4/65kDa, pl5.4/60kDa, pl5.4/48kDa, pI5.4/40kDa, pI5.4/35kDa) at booting stage were present in Xiaoyan No.6A and absent in Nongda 3237A. pl6...
  75. ncbi Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation
    Sebastian Leibl
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Surg Pathol 30:450-6. 2006
    ..type CKs (34betaE12, CK5/6, CK14, CK17) and vimentin antibodies, antibodies to established (SMA, CD10, p63, S-100, maspin, calponin, GFAP, SM-myosin), and novel (CD29, 14-3-3sigma) myoepithelial markers, as well as antibodies to CD34, ..
  76. ncbi Detection of minimal gastric cancer cells in peritoneal washings by focused microarray analysis with multiple markers: clinical implications
    Kazuhiko Mori
    Department of Gastrointestinal Surgery, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Ann Surg Oncol 14:1694-702. 2007
    ..A reverse transcriptase-polymerase chain reaction-based assay with multiple marker genes or immunocytochemistry was assessed as an alternative method of gathering the same kind of data as cytology...
  77. ncbi PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions
    Alessandra Matavel
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
    Channels (Austin) 4:3-11. 2010
    ..more sensitive to stimulation of PIP(2) production, by overexpression of phosphatidylinositol-4-phosphate-5-kinase (PI5-kinase). In addition, c-terminus mutants showed a potentiated regulation by PKA...
  78. ncbi Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors
    Stephan Schwarz
    Department of Pathology, University of Regensburg, Germany
    Oral Oncol 44:563-70. 2008
    b>Maspin, a 42kDa protein, belongs to the serine protease inhibitor (serpin) family and is suggested to have inhibitory effects on tumor-induced angiogenesis, tumor cell motility, invasion and metastasis and influences prognosis of tumor ..
  79. ncbi Establishment of a human T-cell line constitutively producing several eosinophil chemotactic lymphokines and their functional heterogeneity on eosinophils
    M Hirashima
    Department of Pathology, Kumamoto University Medical School, Japan
    Lymphokine Cytokine Res 11:331-8. 1992
    ..eosinophil chemotactic factors (ECF) for eosinophils from healthy individuals with different isoelectric point of PI5, PI6, PI7, PI8, and PI9. Molecular weight of all the ECF was about 30,000 to 45,000...
  80. ncbi Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer
    Pier Francesco Ferrucci
    Divisions of Hemato oncology and Biostatistics and Epidemiology, European Institute of Oncology, Milan, Italy
    Clin Cancer Res 10:6039-46. 2004
    ..colony-stimulating factor-mobilized peripheral blood progenitor cell collections (PBPCCs) using cytokeratin (CK), maspin (MAS), and mammaglobin (MAM) genes as epithelial cell markers...
  81. doi NSAIDs and breast cancer: a possible prevention and treatment strategy
    A Agrawal
    Hedley Atkins Breast Unit, Guy s Hospital, London, UK
    Int J Clin Pract 62:444-9. 2008
    ..Abnormally upregulated COX and prostaglandins are features of breast cancer so NSAIDs might have a role in treatment and prevention of the disease...
  82. ncbi The myoepithelial cell: its role in normal mammary glands and breast cancer
    M Sopel
    Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland
    Folia Morphol (Warsz) 69:1-14. 2010
    ..g. maspin) limiting cancer growth, invasiveness, and neoangiogenesis...
  83. ncbi Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells
    Elke Burgermeister
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 22:3888-900. 2003
    ..a differentiated phenotype, as evinced by analysis of cell-specific differentiation markers: protein levels of maspin were elevated and perinuclear lipid droplets accumulated...
  84. pmc Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells
    Ying Wai Lam
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e9075. 2010
    ..Thus, our primary objective was to identify S-nitrosylated targets in an immortalized normal prostate epithelial cell line, NPrEC...
  85. ncbi [Correlation of hTERT expression to maspin and bFGF expression and their significance in glioma]
    Dong lin Wang
    Department of Pathology, Medical College, Nantong University, Nantong, Jiangsu, 226001, P R China
    Ai Zheng 26:601-6. 2007
    ..Its expression is regulated by many factors. This study was to detect the expression of hTERT, maspin, and basic fibroblast growth factor (bFGF) in glioma, and analyze their correlations and their significance in ..
  86. ncbi Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor (VEGF)
    Jae Hoon Cho
    Department of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Kon Kuk University, Seoul, Republic of Korea
    Oral Oncol 43:272-7. 2007
    ..Mutant-type p53 and VEGF are known to be related to angiogenesis, and maspin is a potent angiogenic inhibitor but its role in tongue cancer has scarcely been examined...
  87. pmc Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Cancer Res 67:3535-9. 2007
    ..b>Maspin, a non-inhibitory serpin, plays an important role in mammary gland development and remodeling...
  88. ncbi Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta
    Reiko Tokuyama
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Bone Miner Res 22:1581-91. 2007
    b>Maspin, a serine protease inhibitor, is expressed by formative osteoblasts...
  89. ncbi Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene
    Bo Zhang
    Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:543-6. 2007
    ..5-Aza-CdR) on the proliferation of MDA-MB-435S cells and the expression of tumor suppressor gene maspin were investigated...
  90. ncbi Expression of maspin in mammary gland tumors of the dog
    A Espinosa de los Monteros
    Departamento de Morfologia, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, Trasmontana s n, Arucas, Las Palmas 35416, Spain
    Vet Pathol 42:250-7. 2005
    b>Maspin is a serine protease inhibitor that inhibits tumor invasion and metastasis in human breast cancer and is consistently expressed by mammary myoepithelial cells (MECs)...
  91. ncbi Expression of maspin and kai1 and their clinicopathological significance in carcinogenesis and progression of gastric cancer
    Hua Chuan Zheng
    The Fourth Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001
    Chin Med Sci J 19:193-8. 2004
    To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer.
  92. ncbi [Transcription regulation of 5-Aza-2'-deoxycytidine on maspin gene demethylation in RKO human colorectal cell line]
    Bo Tang
    Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing, China
    Zhonghua Wei Chang Wai Ke Za Zhi 9:260-3. 2006
    To detect the methylation status of 5'CpG island in the core promotor of maspin gene in RKO human colorectal cell line,and to explore the transcription regulation of DNA 5'CpG island demethylation on maspin tumor suppressor gene and its ..
  93. ncbi Maspin plays an essential role in early embryonic development
    Fei Gao
    Baylor College of Medicine, Department of Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Development 131:1479-89. 2004
    b>Maspin (Mp) is a member of the serpin family with inhibitory functions against cell migration, metastasis and angiogenesis. To identify its role in embryonic development in vivo, we generated maspin knockout mice by gene targeting...
  94. pmc Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two coiled-coil-nucleotide-binding-leucine-rich repeat genes
    Sang Kyu Lee
    Plant Metabolism Research Center and Graduate School of Biotechnology, Kyung Hee University, Yongin, Korea
    Genetics 181:1627-38. 2009
    ..To understand the molecular basis of Pi5-mediated resistance to M...
  95. doi High expression of maspin is associated with early tumor relapse in breast cancer
    Kristiina M Joensuu
    Department of Pathology and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland
    Hum Pathol 40:1143-51. 2009
    b>Maspin is a serine protease inhibitor with tumor suppressor activity. Maspin can suppress tumor growth and metastasis in vivo and tumor cell motility and invasion in vitro...
  96. ncbi Gamma linolenic acid regulates expression of maspin and the motility of cancer cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Biochem Biophys Res Commun 237:639-44. 1997
    b>Maspin, mammary serine protease inhibitor, is a recently identified tumour suppressor and has a profound effect on cell motility...
  97. ncbi [Influence of microencapsulated ovary cells modified with maspin gene on the microvessel density and lung metastasis of breast carcinoma]
    Yue Long Pan
    Department of Tumor, Hangzhou First People s Hospital, Hangzhou 310006, China
    Zhonghua Yi Xue Za Zhi 88:92-5. 2008
    To observe the inhibition of maspin on the angiogenesis in tumor and lung metastasis of breast carcinoma and the feasibility of treatment of tumor by microencapsulated transgene cells in vivo.
  98. ncbi Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen
    Zhila Khalkhali-Ellis
    Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 10:449-54. 2004
    ..In this study, we examined the ability of hormones to regulate the expression of a tumor suppressor gene, maspin, which is a serine protease inhibitor (serpin) that plays an important role in mammary gland development and is ..
  99. ncbi Expression of maspin in papillary Ta/T1 bladder neoplasms
    Stella Blandamura
    Section of Pathological Anatomy, Department of Medico Diagnostic Sciences and Special Therapies, University of Padova, Italy
    Anticancer Res 28:471-8. 2008
    The aim of the present study was to evaluate maspin expression in bladder urothelial papillary neoplasms and test the results for correlation with clinicopathological parameters.
  100. pmc Maspin expression in carcinoma ex pleomorphic adenoma
    M T Martins
    Department of Oral Pathology, School of Dentistry, University of Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    J Clin Pathol 58:1311-4. 2005
    To investigate the presence and distribution of the protein maspin in carcinoma ex pleomorphic adenoma (CXPA).
  101. ncbi Immunohistochemical detection of uPA, uPAR, PAI-1, and maspin in ameloblastic tumors
    H Kumamoto
    Division of Oral Pathology, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Oral Pathol Med 36:488-94. 2007
    ..in progression of odontogenic tumors, expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1), and maspin was analyzed in ameloblastic tumors as well as in tooth germs.

Research Grants43

  1. DIFFERENTIALLY EXPRESSED GENES IN PRIMARY BREAST CANCER
    ARTHUR PARDEE; Fiscal Year: 1999
    ..In addition we have investigated several candidate tumor suppressor genes of which maspin, which is a protease inhibitior, shows promise in both diagnostic and therapeutic applications...
  2. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..The normal cornea synthesizes a number of anti-angiogenic molecules, one of which is maspin, a non-inhibitory Serpin that regulates adhesion, migration and invasion of corneal fibroblasts as well as other ..
  3. Role of Maspin in Breast Cancer Progression
    Ming Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Maspin is a unique member of the serpin family with diverse functions...
  4. Regulation of Polarized Traffic by PI-Metabolizing Enz
    Ora A Weisz; Fiscal Year: 2012
    ..Consistent with this idea, that the three isoforms of PI5-kinase (the enzymes that generate cell surface PIP2) are differentially localized in polarized renal epithelial ..
  5. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
    ..Unfortunately, PC bone metastasis has no cure. Our long-term goal is to investigate the therapeutic potential of maspin in treating PC bone metastasis. Maspin is a novel epithelial-specific serine protease inhibitor (serpin)...
  6. Molecular Mechanisms of Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2013
    ..role of IKKa/[unreadable] in cell transformation and the inhibitory activity of apigenin, ii) the role of IKKa on maspin suppression and its modulation by apigenin, iii) the role of IKK[unreadable] on activity and cellular distribution ..
  7. TGF-Beta signaling and microRNA processing: Implications for invasion and metasta
    ANA CLARA PEREIRA AZEVEDO-POULY; Fiscal Year: 2012
    ..g. TIMP3, PDCD4, RECK and maspin)...
  8. Validation Study of Select Biomarkers for the Diagnostic of Pancreatic Cancer
    MICHELLE ANN ANDERSON; Fiscal Year: 2012
    ..I propose a validation study of a panel of biomarkers (maspin, cathepsin E, ATDC, CEACAM-1, S100P and CEA-6) for the diagnosis of pancreatic cancer...
  9. IKK <alpha>and the Control of Prostate Cancer Metastasis
    Michael Karin; Fiscal Year: 2013
    ..a component of Polycomb repressive complex 1 (PRC1), as well as through repression of the metastasis inhibitor maspin. Nuclear accumulation of activated IKK? was also observed in human PCa and Bmi-1 is a key regulator of PCa stem ..
  10. Assay Development for Screening of Specific IKKalpha Kinase Inhibitors
    Jun Li Luo; Fiscal Year: 2011
    ..This assay utilizes the newly discovered function of nuclear IKK1 kinase that suppresses maspin transcription...
  11. Malignant melanoma: Regulation by AP-2 and PAR-1
    MENASHE BARELI; Fiscal Year: 2012
    ..These genes include MCAM/MUC18, Connexin 43, Maspin, RUNX3, IL-8, Ang-2, GRO, ACRP30, and GITR-ligand...
  12. Extracellular Maspin Acts as a Regulator of the Tumor Microenvironment
    Ivory Dean; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Maspin is an epithelial-specific serine protease inhibitor (serpin) with tumor suppressive function. Exogenously added maspin inhibits tumor cell invasion and motility in vitro...
  13. Biological Function(s) of Maspin
    Mary Hendrix; Fiscal Year: 2009
    ..This competitive renewal application advances our knowledge of the biological function(s) of maspin (mammary serpin) and its interactions with a newly identified binding partner IRF6 (Interferon Regulatory Factor 6)..
  14. Myofibroblasts, T cells and malignant cells interplay in breast cancer metastasis
    Weizhou Zhang; Fiscal Year: 2013
    ..cells, which leads to the activation and nuclear translocation of IKK[unreadable] and in turn the repression of maspin, a key metastasis inhibitor in a variety of cancers...
  15. MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOR
    EILEEN REMOLD O DONNELL; Fiscal Year: 1999
    ..Substantial evidence places HEI as a member, with PAI-2, SCCA, maspin and ovalbumin, of the Ov- serpin family of proteins, characterized by internal noncleavable secretion signals and ..
  16. Regulation of Mdm2 activity by kinase signaling pathways
    Lindsey D Mayo; Fiscal Year: 2013
    ..The role of Mdm2 in regulating pVHL and p53 prevents the induction of the tumor suppressor Maspin. Thus, our central hypothesis is cell surface signaling pathways change Mdm2 to a neddylating enzyme, which then ..
  17. Maspin in the Cornea
    SALLY TWINING; Fiscal Year: 2005
    ..Like many epithelial cells, normal corneal epithelial and endothelial cells synthesize maspin. Surprisingly, normal human corneal stromal cells also synthesize maspin, the only non-epithelial cell type known ..
  18. High-Throughput HomeLab System - R-AXIS++ Option
    Jung Ja Kim; Fiscal Year: 2003
    ..13) Unique amino domains and AMP deaminase isoform diversity, (14) Proteases and Corneal Ulceration, (15) Maspin in the Cornea, (16) Structure and Function of Methylglyoxal Synthase, (17) Specific inhibitors for a non-specific ..
  19. LARGE SCALE DIGITAL CELL ANALYSIS SYSTEM
    Michael Mackey; Fiscal Year: 2004
    ..which will analyze changes in cell motility that are known to occur when a particular tumor suppressor gene, maspin, is silenced in metastatic human cancer cells...
  20. HIRH IN GASTROINTESTINAL MALIGNANCIES
    GRAHAM BARNARD; Fiscal Year: 2001
    ..g. maspin and integrins in breast cancer, PTI-1 in prostate cancer...
  21. Maspin as a Regulator of Protease Expression
    Jaron Lockett; Fiscal Year: 2006
    b>Maspin functions to inhibit the urokinase plasminogen activator bound to its receptor, which decreases plasminogen activation, mediates internalization, and sensitizes cells to apoptosis...
  22. Role of an Epithelial Ets Factor in Breast Cancer
    DENNIS WATSON; Fiscal Year: 2004
    ..Mouse Pdef is down-regulated in tumors in Neu transgenic mice. Pdef activates the tumor metastasis suppressor maspin while downregulating the metastasis promoter uPA...
  23. Microarray Technology to Profile CpG Island Methylation
    Bernard Futscher; Fiscal Year: 2005
    ..4) Develop and implement a public database for the dissemination and mining of the CGI array data ..
  24. Genomic Methylation: A Mechanism to Alter Tumor Phenotype
    Bernard Futscher; Fiscal Year: 2009
    ..2) Define further the mechanism by which reversal of genetic and epigenetic lesions synergize to reactivate silenced genes. 3) Identify new genes that are controlled by 5-methylcytosine in breast cancer. ..
  25. Epigenetic Remodeling by Environmental Arsenicals
    Bernard Futscher; Fiscal Year: 2009
    ....
  26. Protein interactions by analytical ultracentrifugation
    PETER GETTINS; Fiscal Year: 2007
    ..The knowledge gained will be invaluable for design of therapeutics against such infections or in amelioration of diseases associated with aberrant functioning of processes such as blood coagulation. [unreadable] [unreadable] [unreadable]..
  27. CALMODULIN IN ANDROGEN REGULATION OF PROSTATE CANCER
    Prem Veer Reddy; Fiscal Year: 2003
    ....
  28. MALDI-TOF MASS SPECTROMETER
    David Friedman; Fiscal Year: 2003
    ..The acquisition of the requested PRC-dedicated MALDI-TOF instrument with automated data acquision and bioinformatics will allow the PRC to meet the increasing demand for protein identification services from its user base at Vanderbilt. ..
  29. 3rd Intl Symp on Serpin Biology, Structure and Function
    PETER GETTINS; Fiscal Year: 2002
    ..v) To provide an opportunity for promising junior scientists and minorities to play a major role in the meeting. ..
  30. ULTRASENSITIVE CALORIMETRY SYSTEM FOR BIOMOLECULES
    PETER GETTINS; Fiscal Year: 2001
    ..abstract_text> ..
  31. Regulation of maspin in placental development
    ANUJA DOKRAS JAGASIA; Fiscal Year: 2004
    ..We have demonstrated a specific timeline for the expression of maspin, novel tumor suppressor gene in placental invasion and development...
  32. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  33. PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTES
    Brian Nickoloff; Fiscal Year: 2005
    ....
  34. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  35. Cell Death in Normal and Diseased Human Epidermis
    Brian Nickoloff; Fiscal Year: 2006
    ..abstract_text> ..
  36. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009
    ....
  37. Structural examination of serpin-protein interactions
    PETER GETTINS; Fiscal Year: 2009
    ..Dudley Strickland. ..
  38. 900MHz NMR for Structural Biology in Chicago
    PETER GETTINS; Fiscal Year: 2007
    ..As part of the facility, a resource will be established for development of procedures for intein-based segmental isotopic labeling of proteins, as well as for production of segmentally labeled DNA and RNA species. ..
  39. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  40. Epigenetic factors governing SOD2 gene expression
    Frederick Domann; Fiscal Year: 2007
    ..abstract_text> ..
  41. FUNCTION AND DYSFUNCTION IN HUMAN ANTITHROMBINS
    PETER GETTINS; Fiscal Year: 2007
    ..For antithrombins that have been activated by mutation,[unreadable] x-ray crystallography, through collaboration with Dr. Robin Carrell,[unreadable] will be used.[unreadable]..
  42. ACQUISITION OF CRYOPROBE FOR 600 MHZ NMR SPECTROMETER
    PETER GETTINS; Fiscal Year: 2001
    ..Olson, with interests in serpin inhibition mechanism, Dr. Patston, with interests in the structure of the serpin angiotensinogen, and Dr. Silver, who is characterizing a unique silver binding protein, silE. ..