MASP2

Summary

Gene Symbol: MASP2
Description: mannan binding lectin serine peptidase 2
Alias: MAP19, MASP-2, MASP1P1, sMAP, mannan-binding lectin serine protease 2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannose-binding protein-associated serine protease 2, small MBL-associated protein
Species: human
Products:     MASP2

Top Publications

  1. Novovic S, Andersen A, Ersbøll A, Jorgensen L, Nielsen H, Jensenius J, et al. Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis. Pancreas. 2011;40:1097-102 pubmed publisher
    ..Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP. ..
  2. Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, et al. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol. 2012;189:3957-69 pubmed publisher
    ..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway. ..
  3. Héja D, Kocsis A, Dobó J, Szilágyi K, Szasz R, Zavodszky P, et al. Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2. Proc Natl Acad Sci U S A. 2012;109:10498-503 pubmed publisher
    ..MASP-1 activates MASP-2 and, moreover, inhibition of MASP-1 prevents autoactivation of MASP-2. Furthermore we demonstrated that MASP-1 produces 60% of C2a responsible for C3 convertase formation. ..
  4. Boldt A, Luz P, Messias Reason I. MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease. Clin Immunol. 2011;140:63-70 pubmed publisher
    ..Mannose-binding lectin (MBL) initiates complement on Trypanosoma cruzi through the MBL-associated serine protease 2 (MASP2)...
  5. Takahashi M, Endo Y, Fujita T, Matsushita M. A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int Immunol. 1999;11:859-63 pubmed
    ..Here we report that the human MBL-MASP complex contains a new 22 kDa protein [small MBL-associated protein (sMAP)] bound to MASP-1...
  6. Degn S, Thiel S, Nielsen O, Hansen A, Steffensen R, Jensenius J. MAp19, the alternative splice product of the MASP2 gene. J Immunol Methods. 2011;373:89-101 pubmed publisher
    ..The MASP2 gene encodes two proteins, MASP-2 and MAp19. MASP-2 is the serine protease responsible for lectin pathway activation...
  7. Ramasawmy R, Spina G, Fae K, Pereira A, Nisihara R, Messias Reason I, et al. Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology. Clin Vaccine Immunol. 2008;15:932-6 pubmed publisher
    ..0022; odds ratio, 3.5 [95% confidence interval, 1.6 to 7.7]). No association was detected with the variant of the MASP2 gene...
  8. Stover C, Endo Y, Takahashi M, Lynch N, Constantinescu C, Vorup Jensen T, et al. The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. Genes Immun. 2001;2:119-27 pubmed
    ..The MASP1 gene is located on chromosome 3q27, the MASP2 gene on chromosome 1p36.23-31...
  9. Stengaard Pedersen K, Thiel S, Gadjeva M, Møller Kristensen M, Sørensen R, Jensen L, et al. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med. 2003;349:554-60 pubmed

More Information

Publications91

  1. Gulla K, Gupta K, Krarup A, Gal P, Schwaeble W, Sim R, et al. Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot. Immunology. 2010;129:482-95 pubmed publisher
    ..Additionally, MASP-catalysed deposition and polymerization of fibrin on the surface of micro-organisms may be protective by limiting the dissemination of infection. ..
  2. St Swierzko A, Cedzynski M, Domzalska Popadiuk I, MacDonald S, Borkowska Klos M, Atkinson A, et al. Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations. Mol Immunol. 2009;46:1696-701 pubmed publisher
    ..Among 362 samples tested for the D120G single nucleotide polymorphism (SNP) of the MASP2 gene, no homozygote for that mutation was found...
  3. Sorensen G, Petersen I, Thiel S, Fenger M, Christensen K, Kyvik K, et al. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genet Epidemiol. 2007;31:31-41 pubmed
    ..34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits. ..
  4. Thiel S, Vorup Jensen T, Stover C, Schwaeble W, Laursen S, Poulsen K, et al. A second serine protease associated with mannan-binding lectin that activates complement. Nature. 1997;386:506-10 pubmed
    ..Thus complement activation through MBL, like the classical pathway, involves two serine proteases and may antedate the development of the specific immune system of vertebrates. ..
  5. de Rooij B, van Hoek B, ten Hove W, Roos A, Bouwman L, Schaapherder A, et al. Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology. 2010;52:1100-10 pubmed publisher
    ..in the mannose-binding lectin gene (MBL2), the ficolin-2 gene (FCN2), and the MBL-associated serine protease gene (MASP2) of recipients and donors were determined...
  6. Seyfarth J, Garred P, Madsen H. Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes. Mol Immunol. 2006;43:962-71 pubmed
    ..The mRNA distribution of masp1 and masp2 were found very similar to that of mbl2, while masp3 mRNA seemed ubiquitous present at quite high levels when ..
  7. Ytting H, Christensen I, Thiel S, Jensenius J, Nielsen H. Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality. Clin Cancer Res. 2005;11:1441-6 pubmed
    ..Postoperative infection could not be shown to be associated with MASP-2 levels. ..
  8. Stover C, Thiel S, Thelen M, Lynch N, Vorup Jensen T, Jensenius J, et al. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. J Immunol. 1999;162:3481-90 pubmed
    ..In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/..
  9. Valles X, Sarrias M, Casals F, Farnós M, Piner R, Suarez B, et al. Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children. Tissue Antigens. 2009;74:298-307 pubmed publisher
    ..Polymorphisms impairing the quantity and/or the functional activity of proteins encoded by the MBL2 and MASP2 genes have been reported in all human populations showing different allelic frequency and distribution...
  10. Holmberg V, Onkamo P, Lahtela E, Lahermo P, Bedu Addo G, Mockenhaupt F, et al. Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J. 2012;11:61 pubmed publisher
    ..Placental malaria was significantly associated with SNPs in the lectin pathway genes MBL2, MASP2, FCN2 and in properdin...
  11. Schafranski M, Pereira Ferrari L, Scherner D, Torres R, de Messias Reason I. Functional MASP2 gene polymorphism in patients with history of rheumatic fever. Hum Immunol. 2008;69:41-4 pubmed publisher
    ..The Asp105Gly MASP2 mutation (D105G) was detected by polymerase chain reaction-restriction fragment length polymorphism in 148 ..
  12. Olesen H, Jensenius J, Steffensen R, Thiel S, Schiøtz P. The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier. Clin Immunol. 2006;121:324-31 pubmed
    ..However, heterozygosity for the D105G mutation of MASP-2 had no correlation to MBL pathway function or poor lung function. Lung function was higher in the MBL deficiency determining genotypes (XA/YO+YO/YO) than in the other genotypes. ..
  13. Unterberger C, Hanson S, Klingenhoff A, Oesterle D, Frankenberger M, Endo Y, et al. Stat3 is involved in control of MASP2 gene expression. Biochem Biophys Res Commun. 2007;364:1022-5 pubmed
    ..Comparative bioinformatic analysis of the MASP2 promoter regions in human, mouse, and rat, revealed conservation of two putative Stat binding sites, termed StatA ..
  14. Ytting H, Christensen I, Steffensen R, Alsner J, Thiel S, Jensenius J, et al. Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. Scand J Immunol. 2011;73:122-7 pubmed publisher
    ..In contrast to what has been demonstrated for serum levels of MBL and MASP-2, the genotypes do not predict disease course of the CRC patients. ..
  15. Thiel S, Steffensen R, Christensen I, Ip W, Lau Y, Reason I, et al. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun. 2007;8:154-63 pubmed
    ..examined human populations for MASP-2 levels, MASP-2 function and for the presence of mutations in coding exons of MASP2. The MASP-2 levels were lowest in Africans from Zambia (median, 196 ng/ml) followed by Hong Kong Chinese (262 ng/..
  16. Schlapbach L, Aebi C, Otth M, Leibundgut K, Hirt A, Ammann R. Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients. Pediatr Infect Dis J. 2007;26:989-94 pubmed
    ..In this study, MASP-2 deficiency was associated with an increased risk of FN in children treated with chemotherapy for cancer. MASP-2 deficiency represents a novel risk factor for chemotherapy-related infections. ..
  17. Thiel S, Kolev M, Degn S, Steffensen R, Hansen A, Ruseva M, et al. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol. 2009;182:2939-47 pubmed publisher
    ..We find the R439H variant is common in Sub-Saharan Africans with a gene frequency of 10%. Our results indicate that individuals with different types of MASP-2 defects may be identified through genotyping. ..
  18. Zhang M, Hou Y, Cavusoglu E, Lee D, Steffensen R, Yang L, et al. MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans. Int J Cardiol. 2013;166:499-504 pubmed publisher
    ..These results indicate an involvement of MASP-2 in ischemia-related necrotic myocardial injury in humans. ..
  19. Lozano F, Suarez B, Munoz A, Jensenius J, Mensa J, Vives J, et al. Novel MASP2 variants detected among North African and Sub-Saharan individuals. Tissue Antigens. 2005;66:131-5 pubmed
    ..Recently, investigations on Danes revealed the existence of a mutation on the MASP2 gene, which introduces an amino acid substitution in the CUB1 domain (Asp105Gly; numbering refers to the mature ..
  20. Ytting H, Christensen I, Thiel S, Jensenius J, Nielsen H. Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer. Hum Immunol. 2008;69:414-20 pubmed publisher
    ..High postoperative levels of MASP-2 are associated with poor prognosis in patients curatively resected for CRC. A change of the MASP-2 level from preoperative levels was not, per se, predictive of recurrent disease or survival. ..
  21. Tulio S, Faucz F, Werneck R, Olandoski M, Alexandre R, Boldt A, et al. MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection. Hum Immunol. 2011;72:912-5 pubmed publisher
    ..We examined several MASP2 functional polymorphisms in 104 Brazilian patients with moderate and severe chronic hepatitis C using the primers ..
  22. Kocsis A, Kekesi K, Szasz R, Végh B, Balczer J, Dobó J, et al. Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. J Immunol. 2010;185:4169-78 pubmed publisher
    ..Because the lectin pathway has been implicated in several life-threatening pathological states, these inhibitors should be considered as lead compounds toward developing lectin pathway blocking therapeutics. ..
  23. Suganya V, Geetha A, Sujatha S. Urine proteome analysis to evaluate protein biomarkers in children with autism. Clin Chim Acta. 2015;450:210-9 pubmed publisher
    ..Increased urinary kininogen-1 level in all the autistic children and the possibility of this protein as a diagnostic marker need further investigation. ..
  24. Hamilton Williams E, Rainbow D, Cheung J, Christensen M, Lyons P, Peterson L, et al. Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mamm Genome. 2013;24:358-75 pubmed publisher
    ..4, with Lck remaining a candidate gene within Idd9.1. One of the Idd9.2 regions contains the candidate genes Masp2 (encoding mannan-binding lectin serine peptidase 2) and Mtor (encoding mammalian target of rapamycin)...
  25. Blamires S, Kasumovic M, Tso I, Martens P, Hook J, Rawal A. Evidence of Decoupling Protein Structure from Spidroin Expression in Spider Dragline Silks. Int J Mol Sci. 2016;17: pubmed publisher
    ..thought to be facilitated by two spidroins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2), under the assumption that protein secondary structures are coupled with the expressed spidroins...
  26. Ahmad J, Muhammad K, Lee M, Baik S. Endoscopic Image Classification and Retrieval using Clustered Convolutional Features. J Med Syst. 2017;41:196 pubmed publisher
    ..each cluster are collected into a single, layout-preserving feature map using a spatial maximal activator pooling (SMAP) approach...
  27. Kjaer T, Thiel S, Andersen G. Toward a structure-based comprehension of the lectin pathway of complement. Mol Immunol. 2013;56:413-22 pubmed publisher
    ..In addition MASP-3 and the non-catalytic MAp19 and MAp44 presumably play regulatory functions, but the exact function of the MASP-3 protease remains to be ..
  28. Paréj K, Hermann A, Donáth N, Zavodszky P, Gal P, Dobó J. Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation. Mol Immunol. 2014;59:1-9 pubmed publisher
    ..The existence of heterodimers influences the current view on the composition of lectin pathway complexes and their activation. ..
  29. Defraine V, Schuermans J, Grymonprez B, Govers S, Aertsen A, Fauvart M, et al. Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii. Antimicrob Agents Chemother. 2016;60:3480-8 pubmed publisher
    ..Artilysin Art-175 comprises a modified variant of endolysin KZ144 with an N-terminal fusion to SMAP-29. Previously, we have shown the high susceptibility of Pseudomonas aeruginosa to Art-175...
  30. Dobó J, Szakács D, Oroszlán G, Kortvely E, Kiss B, Boros E, et al. MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked. Sci Rep. 2016;6:31877 pubmed publisher
    ..For this study we evolved a specific MASP-3 inhibitor and unambiguously proved that activated MASP-3 is the exclusive pro-FD activator in resting blood, which demonstrates a fundamental link between the lectin and alternative pathways. ..
  31. Larracas C, Hekman R, Dyrness S, Arata A, Williams C, Crawford T, et al. Comprehensive Proteomic Analysis of Spider Dragline Silk from Black Widows: A Recipe to Build Synthetic Silk Fibers. Int J Mol Sci. 2016;17: pubmed publisher
    ..of spider dragline silk fibers have been attributed to two spidroins, major ampullate spidroins 1 and 2 (MaSp1 and MaSp2)...
  32. Garred P, Genster N, Pilely K, Bayarri Olmos R, Rosbjerg A, Ma Y, et al. A journey through the lectin pathway of complement-MBL and beyond. Immunol Rev. 2016;274:74-97 pubmed publisher
    ..This review summarizes the characteristics of the molecules in the lectin pathway. ..
  33. Thergaonkar R, Narang A, Gurjar B, Tiwari P, Puraswani M, Saini H, et al. Targeted exome sequencing in anti-factor H antibody negative HUS reveals multiple variations. Clin Exp Nephrol. 2018;22:653-660 pubmed publisher
    ..e., CFH, CFHR1-5, CFI, CFB, C3, CD46, MASP2, DGKE, ADAMTS13, THBD and PLG using next-generation DNA sequencing and for copy number variation in CFHR1-3...
  34. Zhao R, Chen W, Chang B, Fan R, Liu L, Pan Y, et al. [Triperygium wilfordii multiglucoside ameliorates kidney damage in diabetic rats by inhibiting the expressions of MBL and MASP2]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1498-1503 pubmed
    ..TWM) on the expressions of mannose-binding lectin (MBL) and mannan-binding lectin serine peptidase 2 (MASP2) in the kidney of diabetic rats, and discuss the protective role of TWM in diabetic nephropathy and its possible ..
  35. Li J, Zhu L, Zuo D, Zhang L, Lu X, Chen Z, et al. [Plasma mannan?binding lectin and MBL?associated serine protease 2 in patients with hepatocellular carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1667-1672 pubmed
    ..010) and 0.694 for MASP?2 (P=0.003). The sensitivities of MBL and MASP?2 were 50% and 89.1% in the diagnosis of HCC, respectively. MBL and MASP?2 are associated with the inflammatory state and disease progression in patients with HCC. ..
  36. Sekine H, Takahashi M, Iwaki D, Fujita T. The role of MASP-1/3 in complement activation. Adv Exp Med Biol. 2013;735:41-53 pubmed
    ..In addition, MASP-1 was able to activate MASP-2 and MASP-3 as C1r activates C1s. Thus, MASP-1 and MASP-3 seem to be involved in activation of both the lectin and alternative pathways. ..
  37. Chen M, Liang Y, Li W, Wang M, Hu L, Abuaku B, et al. Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis. BMC Infect Dis. 2015;15:151 pubmed publisher
    ..282, 1.513) and 1.142 (95% CI: 0.755, 1.530) respectively (P<0.05). Polymorphisms of MBL (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of TB, and there were gene-gene interactions among them. ..
  38. Goshima M, Sekiguchi R, Matsushita M, Nonaka M. The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena. Dev Comp Immunol. 2016;61:13-24 pubmed publisher
    ..In addition to the absence of MBL and ficolin, the MASP transcripts lacked the serine protease domain, suggesting that the lectin pathway was lost in the hammerhead shark lineage. ..
  39. Farrar C, Tran D, Li K, Wu W, Peng Q, Schwaeble W, et al. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest. 2016;126:1911-25 pubmed publisher
    ..Given these results, we conclude that lectin complement pathway activation triggered by ligand-CL-11 interaction in postischemic tissue is a potent source of acute kidney injury and is amenable to sugar-specific blockade. ..
  40. Orsini F, Chrysanthou E, Dudler T, Cummings W, Takahashi M, Fujita T, et al. Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1. J Neuroinflammation. 2016;13:213 pubmed publisher
  41. Krogh S, Holt C, Steffensen R, Funck K, Høyem P, Laugesen E, et al. Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene. Clin Exp Immunol. 2017;189:103-112 pubmed publisher
    ..In conclusion, MASP-1 levels were higher among patients with type 2 diabetes and diabetic mice. The mechanism behind this increase remains elusive. ..
  42. Benamú M, Lacava M, Garcia L, Santana M, Fang J, Wang X, et al. Nanostructural and mechanical property changes to spider silk as a consequence of insecticide exposure. Chemosphere. 2017;181:241-249 pubmed publisher
    ..differed between treatments, indicating that insecticide exposure induced downregulation of the silk protein MaSp2. The spiders in the control group had stronger, tougher and more extensible silks than those in the insecticide ..
  43. Kennedy A, Wijeyewickrema L, Huglo A, Lin C, Pike R, Cowman A, et al. Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites. J Immunol. 2017;198:4728-4737 pubmed publisher
    ..When bound to the merozoite surface, C1-INH retains its ability to complex with and inhibit C1s, MASP1, and MASP2, the activating proteases of the complement cascade. P. falciparum merozoites that lack PfMSP3...
  44. Wang Y, Xiu Y, Bi K, Ou J, Gu W, Wang W, et al. Integrated analysis of mRNA-seq in the haemocytes of Eriocheir sinensis in response to Spiroplasma eriocheiris infection. Fish Shellfish Immunol. 2017;68:289-298 pubmed publisher
    ..We found important immune-related genes (GNPTAB, MASP2, F7, F5, NFATC, TRAF6, MAP3K5, and TRa) in the KEGG pathway, and those genes were confirmed by qRT-PCR analysis...
  45. Sousa F, Casanova V, Findlay F, Stevens C, Svoboda P, Pohl J, et al. Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides. 2017;95:76-83 pubmed publisher
    ..We demonstrate that LL-37, the porcine cathelicidin Protegrin-1, and the ovine cathelicidin SMAP-29 display potent antiviral activity towards HRV and that this activity is visible when either the virus is exposed ..
  46. Neth O, Jack D, Dodds A, Holzel H, Klein N, Turner M. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun. 2000;68:688-93 pubmed
    ..Bound MBL was able to promote C4 deposition in a concentration-dependent manner. We conclude that MBL may be of importance in first-line immune defense against several important pathogens. ..
  47. Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kekesi K, et al. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem. 2012;287:20290-300 pubmed publisher
    ..The 1.28 Å resolution MASP-2 structure reveals significant plasticity of the protease, suggesting that either an induced fit or a conformational selection mechanism should contribute to the extreme specificity of the enzyme. ..
  48. Cervera C, Lozano F, Saval N, Gimferrer I, Ibáñez A, Suarez B, et al. The influence of innate immunity gene receptors polymorphisms in renal transplant infections. Transplantation. 2007;83:1493-500 pubmed
    ..Functionally relevant mutations in MBL2, MASP2, and TLR4 genes were determined by DNA sequencing...
  49. Świerzko A, Szala Poździej A, Kilpatrick D, Sobociński M, Chojnacka K, Sokołowska A, et al. Components of the lectin pathway of complement activation in paediatric patients of intensive care units. Immunobiology. 2016;221:657-69 pubmed publisher
    ..but no significant differences in the frequency of SNPs of other lectin pathway genes (FCN1, FCN2, FCN3, MASP1/3, MASP2) or TLR receptor genes (TLR2, TLR4) were found...
  50. Chen M, Deng J, Su C, Li J, Wang M, Abuaku B, et al. Impact of passive smoking, cooking with solid fuel exposure, and MBL/MASP-2 gene polymorphism upon susceptibility to tuberculosis. Int J Infect Dis. 2014;29:1-6 pubmed publisher
    ..Further studies are needed to explore details of the mechanisms of association. ..
  51. Catarino S, Boldt A, Beltrame M, Nisihara R, Schafranski M, de Messias Reason I. Association of MASP2 polymorphisms and protein levels with rheumatic fever and rheumatic heart disease. Hum Immunol. 2014;75:1197-202 pubmed publisher
    MASP-2 is a key protein of the lectin pathway of complement system. Several MASP2 polymorphisms were associated with MASP-2 serum levels or functional activity...
  52. Boldt A, Beltrame M, Catarino S, Meissner C, Tizzot R, Messias Reason I. A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection. Mol Immunol. 2016;78:48-56 pubmed publisher
    ..The quality of this response partly depends on MASP2 gene polymorphisms, which modulate MASP-2 function and serum levels...
  53. Stover C, Schwaeble W, Lynch N, Thiel S, Speicher M. Assignment of the gene encoding mannan-binding lectin-associated serine protease 2 (MASP2) to human chromosome 1p36.3-->p36.2 by in situ hybridization and somatic cell hybrid analysis. Cytogenet Cell Genet. 1999;84:148-9 pubmed
  54. Coyle C, Wheelhouse N, Jacques M, Longbottom D, Svoboda P, Pohl J, et al. Ovine trophoblasts express cathelicidin host defence peptide in response to infection. J Reprod Immunol. 2016;117:10-6 pubmed publisher
    ..Using RT-PCR, expression of the CHDP SMAP-29, sBD-1 and sBD-2 was assessed in the AH-1 cell line in response to LPS, 1α,25-dihydroxyvitamin D3 exposure (a ..
  55. Møller Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius J. Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int Immunol. 2007;19:141-9 pubmed
  56. Coelho A, Brandão L, Guimaraes R, Loureiro P, de Lima Filho J, de Alencar L, et al. Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection. J Med Virol. 2013;85:1829-35 pubmed publisher
    ..interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship ..
  57. Li T, Li P, Jia T, Jia X, Zhao X, Cheng Y. [Expression of mannose-binding lectin associated protein 19 (MAp19) in HeLa cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:49-53 pubmed
    To construct an eukaryotic expression vector of mannose-binding lectin associated protein 19 (MAp19) and further express MAp19 fusion proteins. MAp19 gene fragment was amplified by PCR. The eukaryotic expression vector pcDNA3...
  58. Wang Y, Yan J, Shi Y, Li P, Liu C, Ma Q, et al. Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection. BMC Infect Dis. 2009;9:51 pubmed publisher
    ..As the downstream protein of MBL, variants of the MBL-associated serine protease-2 (MASP2) gene may be associated with SARS coronavirus (SARS-CoV) infection in the same population...
  59. Garcia Laorden M, Sole Violan J, Rodriguez de Castro F, Aspa J, Briones M, Garcia Saavedra A, et al. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. J Allergy Clin Immunol. 2008;122:368-74, 374.e1-2 pubmed publisher
    ..MBL and MASP-2 serum levels, as well as lectin pathway activity with regard to MBL2 and MASP2 genotypes, were measured in healthy control subjects...
  60. Dong X, Luo Y, Gao Q, Lu X, Wang Q, Zhang Y, et al. Effects of MBL-associated serine protease-2 (MASP-2) on liquefaction and ulceration in rabbit skin model of tuberculosis. Microb Pathog. 2016;99:282-286 pubmed publisher
    ..This study suggests that hMASP-2 can induce a protective efficacy in BCG-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them. ..
  61. Nielsen R, Vind I, Munkholm P, Jensenius J, Thiel S, Steffensen R, et al. Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn's disease. Gut. 2007;56:311-2 pubmed
  62. Damman J, Kok J, Snieder H, Leuvenink H, van Goor H, Hillebrands J, et al. Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation. Mol Immunol. 2012;50:1-8 pubmed publisher
    ..A total of 12 functional SNPs in the MBL2, FCN2 and MBL-associated serine proteases 2 (MASP2) genes of 1271 donor-recipient pairs were determined...
  63. Kidmose R, Laursen N, Dobó J, Kjaer T, Sirotkina S, Yatime L, et al. Structural basis for activation of the complement system by component C4 cleavage. Proc Natl Acad Sci U S A. 2012;109:15425-30 pubmed
    ..Our results provide a unified structural framework for understanding the early and essential step of C4 cleavage in the elimination of pathogens and altered self through two major pathways of complement activation. ..
  64. Valles X, Roca A, Lozano F, Morais L, Suarez B, Casals F, et al. Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency. Eur Respir J. 2010;36:856-63 pubmed publisher
    ..We aimed to determine the association between invasive pneumococcal disease and MBL2 and MASP2 genetic variants, regarding serotype distribution...
  65. Goeldner I, Skare T, Boldt A, Nass F, Messias Reason I, Utiyama S. Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives. PLoS ONE. 2014;9:e90979 pubmed publisher
    ..MASP-2 levels have been associated with different polymorphisms within MASP2 gene as well as with the risk for inflammatory disorders and infections...
  66. Banda N, Acharya S, Scheinman R, Mehta G, Takahashi M, Endo Y, et al. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017;199:1835-1845 pubmed publisher
    ..In contrast, FCN B-/- and MASP-2-/-/sMAp-/- mice are substantially protected, with clinical disease activity decreased significantly (p..
  67. Harmat V, Gal P, Kardos J, Szilágyi K, Ambrus G, Végh B, et al. The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. J Mol Biol. 2004;342:1533-46 pubmed
  68. Schlapbach L, Aebi C, Fisch U, Ammann R, Otth M, Bigler S, et al. Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis. Pediatr Res. 2008;64:562-6 pubmed publisher
    ..64). In conclusion, infants later developing NEC had significantly higher MASP-2 cord blood levels compared with controls. Higher MASP-2 may favor complement-mediated inflammation and could thereby predispose to NEC. ..
  69. Fu J, Wang J, Luo Y, Zhang L, Zhang Y, Dong X, et al. Association between MASP-2 gene polymorphism and risk of infection diseases: A meta-analysis. Microb Pathog. 2016;100:221-228 pubmed publisher
    ..Similarly, there were no obvious difference in subgroup analysis based on geographical areas and pathogenic microorganisms. ..
  70. Cseh S, Vera L, Matsushita M, Fujita T, Arlaud G, Thielens N. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol. 2002;169:5735-43 pubmed
    ..with mannan-binding lectin (MBL)-associated serine proteases (MASP-1 and -2) and MBL-associated protein 19 (MAp19) in serum and forms complexes able to activate complement...
  71. Matsushita M, Endo Y, Fujita T. Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J Immunol. 2000;164:2281-4 pubmed
    ..serine proteases (MASP), MASP-1 and MASP-2 and its truncated form, small MBL-associated protein (sMAP, also called MAp19). We report here that ficolin/P35, a human serum ficolin, was found to copurify with MASPs and sMAP...
  72. Hamad I, Hunter A, Szebeni J, Moghimi S. Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process. Mol Immunol. 2008;46:225-32 pubmed publisher
  73. Gregory L, Thielens N, Matsushita M, Sorensen R, Arlaud G, Fontecilla Camps J, et al. The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J Biol Chem. 2004;279:29391-7 pubmed
    b>MAp19 is an alternative splicing product of the MASP-2 gene comprising the N-terminal CUB1-epidermal growth factor (EGF) segment of MASP-2, plus four additional residues at its C-terminal end...
  74. Manna P, Obado S, Boehm C, Gadelha C, Sali A, Chait B, et al. Lineage-specific proteins essential for endocytosis in trypanosomes. J Cell Sci. 2017;130:1379-1392 pubmed publisher
    ..the trypanosome AP-1 complex, Trypanosoma brucei (Tb)EpsinR, several endosomal SNAREs plus orthologues of SMAP and the AP-2 associated kinase AAK1 as interacting with clathrin...
  75. Horcajada J, Lozano F, Munoz A, Suarez B, Farinas Alvarez C, Almela M, et al. Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study. Curr HIV Res. 2009;7:218-23 pubmed
    ..HIV infection status, antiretroviral therapy, risk factors for pneumococcal disease, and genotypes of MBL2, MASP2, TLR2 and TLR4 were analyzed...
  76. Vorup Jensen T, Petersen S, Hansen A, Poulsen K, Schwaeble W, Sim R, et al. Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol. 2000;165:2093-100 pubmed
    ..The results suggest that the catalytic activities of MASP-2 split between the two proteases of the C1 complex during the course of vertebrate complement evolution. ..
  77. Brown K, Keogh M, Owsianka A, Adair R, Patel A, Arnold J, et al. Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry. Protein Cell. 2010;1:664-74 pubmed publisher
    ..In conclusion, MBL interacts directly with HCV glycoproteins, which are present on the surface of the virion, resulting in neutralization of HCV particles. ..
  78. Thamm C, Scheibel T. Recombinant Production, Characterization, and Fiber Spinning of an Engineered Short Major Ampullate Spidroin (MaSp1s). Biomacromolecules. 2017;18:1365-1372 pubmed publisher
    ..exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity...
  79. Bronkhorst M, Lomax M, Vossen R, Bakker J, Patka P, Van Lieshout E. Risk of infection and sepsis in severely injured patients related to single nucleotide polymorphisms in the lectin pathway. Br J Surg. 2013;100:1818-26 pubmed publisher
    ..I trauma centre between January 2008 and April 2011 were genotyped for SNPs in MBL2 (mannose-binding lectin 2), MASP2 (MBL-associated serine protease 2) and FCN2 (ficolin 2)...
  80. Kozarcanin H, Lood C, Munthe Fog L, Sandholm K, Hamad O, Bengtsson A, et al. The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation. J Thromb Haemost. 2016;14:531-45 pubmed publisher
    ..This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation. ..
  81. Ameye L, Paesmans M, Thiel S, Jensenius J, Aoun M. M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy. Clin Exp Immunol. 2012;167:303-8 pubmed publisher
    ..No associations were revealed between infections and H-ficolin, L-ficolin or MASP-3. Patients with low M-ficolin are more likely to develop severe infections, whereas MASP-2 showed the opposite. ..
  82. Verma A, Matta A, Shukla N, Deo S, Gupta S, Ralhan R. Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma. Int J Cancer. 2006;118:2930-5 pubmed