MASP2

Summary

Gene Symbol: MASP2
Description: mannan binding lectin serine peptidase 2
Alias: MAP19, MASP-2, MASP1P1, sMAP, mannan-binding lectin serine protease 2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannose-binding protein-associated serine protease 2, small MBL-associated protein
Species: human

Top Publications

  1. ncbi Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
    V Rossi
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel CEA CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 276:40880-7. 2001
  2. ncbi Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus
    Olaf Neth
    Immunobiology Unit, Institute of Child Health and Great Ormond Street Hospital for Children, National Health Service Trust, 30 Guilford Street, London, WC1N 1EH, UK
    J Immunol 169:4430-6. 2002
  3. pmc Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship
    M Carlsson
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Sweden
    Clin Exp Immunol 139:306-13. 2005
  4. ncbi Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
    Rikke Sørensen
    Department of Medical Microbiology and Immunology, Wilhelm Meyers Alle, University of Aarhus, 8000 Aarhus, Denmark
    Springer Semin Immunopathol 27:299-319. 2005
  5. ncbi Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin
    Monique Lacroix
    Institut de Biologie Structurale Jean Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique Commissariat à l Energie Atomique, Universite Joseph Fourier, Grenoble, France
    J Immunol 182:456-65. 2009
  6. ncbi Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Mette Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int Immunol 19:141-9. 2007
  7. ncbi Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 165:878-87. 2000
  8. ncbi Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
    Felicity K Kerr
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 45:670-7. 2008
  9. doi Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis
    Luregn J Schlapbach
    Department of Pediatrics, University of Bern, 3010 Bern, Switzerland
    Pediatr Res 64:562-6. 2008
  10. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003

Detail Information

Publications192 found, 100 shown here

  1. ncbi Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
    V Rossi
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel CEA CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 276:40880-7. 2001
    ..In view of the very low activity of MASP-1 on C3 and C2, our data raise questions about the implication of this protease in complement activation...
  2. ncbi Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus
    Olaf Neth
    Immunobiology Unit, Institute of Child Health and Great Ormond Street Hospital for Children, National Health Service Trust, 30 Guilford Street, London, WC1N 1EH, UK
    J Immunol 169:4430-6. 2002
    ..Complexes of MBL-MASP2 are able to activate the complement system in an Ab and C1-independent fashion after binding of the lectin to ..
  3. pmc Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship
    M Carlsson
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Sweden
    Clin Exp Immunol 139:306-13. 2005
    ..In conclusion, MBL pathway function was affected both by MBL and by MASP-2 genotypes. However, MBL or MASP-2 levels in serum did not affect the clinical outcome in the cohort of CF patients studied...
  4. ncbi Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
    Rikke Sørensen
    Department of Medical Microbiology and Immunology, Wilhelm Meyers Alle, University of Aarhus, 8000 Aarhus, Denmark
    Springer Semin Immunopathol 27:299-319. 2005
    ..The gene frequency of the mutation among Caucasians is 3.6%. It is not found in Chinese, who present a different mutation also associated with MASP-2 deficiency...
  5. ncbi Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin
    Monique Lacroix
    Institut de Biologie Structurale Jean Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique Commissariat à l Energie Atomique, Universite Joseph Fourier, Grenoble, France
    J Immunol 182:456-65. 2009
    ..lectin (MBL) the ability to associate with MBL-associated serine proteases (MASP)-1, -2, -3, and protein MAp19 and to trigger the lectin complement pathway through MASP-2 activation...
  6. ncbi Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Mette Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int Immunol 19:141-9. 2007
    ....
  7. ncbi Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 165:878-87. 2000
    ..In serum, C1r and C1s were found to be associated only with C1q, whereas MASP-1, MASP-2, and a third protein, MAp19 (19-kDa MBL-associated protein), were found to be associated only with MBL...
  8. ncbi Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
    Felicity K Kerr
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 45:670-7. 2008
    ..C1-inhibitor inhibited MASP-2 50-fold faster than C1s and much faster than any other protease tested to date, implying that MASP-2 is a major physiological target of C1-inhibitor...
  9. doi Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis
    Luregn J Schlapbach
    Department of Pediatrics, University of Bern, 3010 Bern, Switzerland
    Pediatr Res 64:562-6. 2008
    ..64). In conclusion, infants later developing NEC had significantly higher MASP-2 cord blood levels compared with controls. Higher MASP-2 may favor complement-mediated inflammation and could thereby predispose to NEC...
  10. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003
    ..Nevertheless, relative rates of reaction with alpha-2-macroglobulin and C1-inhibitor suggest that alpha-2-macroglobulin may be a significant physiological inhibitor of MASP-1...
  11. ncbi MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway
    T Vorup-Jensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunobiology 199:348-57. 1998
    ..Phylogenetic analysis indicates that MASP-2 is closer to C1r and C1s than is MASP-1, but no particular association between MASP-2 and the C4 cleaving enzyme, C1s, can be deduced from sequence comparison...
  12. ncbi The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
    Veronika Harmat
    Protein Modeling Group, Hungarian Academy of Sciences, Eotvos Lorand University, Pázmány Péter sétány 1A, H 1117 Budapest, Hungary
    J Mol Biol 342:1533-46. 2004
    ....
  13. ncbi A second serine protease associated with mannan-binding lectin that activates complement
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Nature 386:506-10. 1997
    ..Thus complement activation through MBL, like the classical pathway, involves two serine proteases and may antedate the development of the specific immune system of vertebrates...
  14. ncbi A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway
    M Takahashi
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int Immunol 11:859-63. 1999
    ..Here we report that the human MBL-MASP complex contains a new 22 kDa protein [small MBL-associated protein (sMAP)] bound to MASP-1...
  15. ncbi The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3
    C Stover
    Department of Microbiology and Immunology, University of Leicester, Leicester, UK
    Genes Immun 2:119-27. 2001
    ..The MASP1 gene is located on chromosome 3q27, the MASP2 gene on chromosome 1p36.23-31...
  16. ncbi Inherited deficiency of mannan-binding lectin-associated serine protease 2
    Kristian Stengaard-Pedersen
    Department of Rheumatology, Aarhus University Hospital, Denmark
    N Engl J Med 349:554-60. 2003
  17. ncbi Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality
    Henriette Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Clin Cancer Res 11:1441-6. 2005
    ..The level of MASP-2 is genetically determined, and the aim of the present study was to evaluate the effect of MASP-2 levels on postoperative infection, recurrence and survival...
  18. ncbi Novel MASP2 variants detected among North African and Sub-Saharan individuals
    F Lozano
    Servei d Immunologia, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Tissue Antigens 66:131-5. 2005
    ..Recently, investigations on Danes revealed the existence of a mutation on the MASP2 gene, which introduces an amino acid substitution in the CUB1 domain (Asp105Gly; numbering refers to the mature ..
  19. ncbi Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes
    Jeanette Seyfarth
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Mol Immunol 43:962-71. 2006
    ..The mRNA distribution of masp1 and masp2 were found very similar to that of mbl2, while masp3 mRNA seemed ubiquitous present at quite high levels when ..
  20. ncbi The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier
    H V Olesen
    Department of Pediatrics A, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Clin Immunol 121:324-31. 2006
    ..However, heterozygosity for the D105G mutation of MASP-2 had no correlation to MBL pathway function or poor lung function. Lung function was higher in the MBL deficiency determining genotypes (XA/YO+YO/YO) than in the other genotypes...
  21. ncbi Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007
    ..34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits...
  22. ncbi Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Genes Immun 8:154-63. 2007
    ..examined human populations for MASP-2 levels, MASP-2 function and for the presence of mutations in coding exons of MASP2. The MASP-2 levels were lowest in Africans from Zambia (median, 196 ng/ml) followed by Hong Kong Chinese (262 ng/..
  23. ncbi Stat3 is involved in control of MASP2 gene expression
    Claudia Unterberger
    Clinical Cooperation Group Inflammatory Lung Diseases GSF National Research Center for Environment and Health, Asklepios Fachkliniken, Gauting, Germany
    Biochem Biophys Res Commun 364:1022-5. 2007
    ..Comparative bioinformatic analysis of the MASP2 promoter regions in human, mouse, and rat, revealed conservation of two putative Stat binding sites, termed StatA ..
  24. ncbi Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients
    Luregn J Schlapbach
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 26:989-94. 2007
    ..The aim of the present study was to determine whether children with cancer and MASP-2 deficiency develop more frequent or more severe episodes of fever and severe chemotherapy-induced neutropenia (FN)...
  25. doi Functional MASP2 gene polymorphism in patients with history of rheumatic fever
    Marcelo Derbli Schafranski
    Departamento de Patologia Médica, Hospital de Clínicas da Universidade Federal do Paraná UFPR, Curitiba, Parana, Brazil
    Hum Immunol 69:41-4. 2008
    ..The Asp105Gly MASP2 mutation (D105G) was detected by polymerase chain reaction-restriction fragment length polymorphism in 148 ..
  26. pmc Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology
    Rajendranath Ramasawmy
    Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Clin Vaccine Immunol 15:932-6. 2008
    ..0022; odds ratio, 3.5 [95% confidence interval, 1.6 to 7.7]). No association was detected with the variant of the MASP2 gene...
  27. doi Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer
    Henriette Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Hum Immunol 69:414-20. 2008
    ..High postoperative levels of MASP-2 are associated with poor prognosis in patients curatively resected for CRC. A change of the MASP-2 level from preoperative levels was not, per se, predictive of recurrent disease or survival...
  28. doi Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 182:2939-47. 2009
    ..We find the R439H variant is common in Sub-Saharan Africans with a gene frequency of 10%. Our results indicate that individuals with different types of MASP-2 defects may be identified through genotyping...
  29. doi Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:1696-701. 2009
    ..Among 362 samples tested for the D120G single nucleotide polymorphism (SNP) of the MASP2 gene, no homozygote for that mutation was found...
  30. doi Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children
    X Valles
    International Research Center in Health of Barcelona CRESIB, Hospital Clínic de Barcelona IDIBAPS, Barcelona, Spain
    Tissue Antigens 74:298-307. 2009
    ..Polymorphisms impairing the quantity and/or the functional activity of proteins encoded by the MBL2 and MASP2 genes have been reported in all human populations showing different allelic frequency and distribution...
  31. pmc Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
    Krishana C Gulla
    School of Life Sciences, DA University, Indore, India
    Immunology 129:482-95. 2010
    ..Additionally, MASP-catalysed deposition and polymerization of fibrin on the surface of micro-organisms may be protective by limiting the dissemination of infection...
  32. doi Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation
    Bert Jan F de Rooij
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Hepatology 52:1100-10. 2010
    ..in the mannose-binding lectin gene (MBL2), the ficolin-2 gene (FCN2), and the MBL-associated serine protease gene (MASP2) of recipients and donors were determined...
  33. doi Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
    Andrea Kocsis
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 185:4169-78. 2010
    ..Because the lectin pathway has been implicated in several life-threatening pathological states, these inhibitors should be considered as lead compounds toward developing lectin pathway blocking therapeutics...
  34. doi Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer
    H Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Scand J Immunol 73:122-7. 2011
    ..In contrast to what has been demonstrated for serum levels of MBL and MASP-2, the genotypes do not predict disease course of the CRC patients...
  35. doi MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease
    Angelica B W Boldt
    Laboratório de Imunopatologia Molecular Hospital de Clínicas, Federal University of Parana, 80060 900, Curitiba, PR, Brazil
    Clin Immunol 140:63-70. 2011
    ..Mannose-binding lectin (MBL) initiates complement on Trypanosoma cruzi through the MBL-associated serine protease 2 (MASP2)...
  36. doi MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection
    Siumara Tulio
    Department of Medical Pathology, Hospital de Clinicas, Federal University of Parana, Curitiba, PR, Brazil
    Hum Immunol 72:912-5. 2011
    ..We examined several MASP2 functional polymorphisms in 104 Brazilian patients with moderate and severe chronic hepatitis C using the primers ..
  37. doi MAp19, the alternative splice product of the MASP2 gene
    Søren E Degn
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    J Immunol Methods 373:89-101. 2011
    ..The MASP2 gene encodes two proteins, MASP-2 and MAp19...
  38. pmc MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans
    Ming Zhang
    Department of Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Int J Cardiol 166:499-504. 2013
    ..We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery...
  39. pmc Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
    Ville Holmberg
    Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
    Malar J 11:61. 2012
    ..Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood...
  40. pmc Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
    Dávid Héja
    Department of Biochemistry, Eotvos Lorand University, H 1117 Budapest, Hungary
    Proc Natl Acad Sci U S A 109:10498-503. 2012
    ..MASP-1 activates MASP-2 and, moreover, inhibition of MASP-1 prevents autoactivation of MASP-2. Furthermore we demonstrated that MASP-1 produces 60% of C2a responsible for C3 convertase formation...
  41. doi Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Immunol 189:3957-69. 2012
    ..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway...
  42. ncbi Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene
    C M Stover
    Department of Microbiology and Immunology, University of Leicester, United Kingdom
    J Immunol 162:3481-90. 1999
    ..In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/..
  43. ncbi A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
    Peter Gal
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, P O Box 7, Budapest H 1518, Hungary
    J Biol Chem 280:33435-44. 2005
    ..Based on the three-dimensional structures of proenzyme and active MASP-2 catalytic fragments, we present model for the active zymogen MASP-2 complex and propose a mechanism for the autoactivation process...
  44. ncbi The role of mannose-binding lectin in health and disease
    M W Turner
    Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Mol Immunol 40:423-9. 2003
    ..For example, the protein appears to influence the severity of several diseases. The mechanism whereby MBL exerts such effects is unclear but one possibility is through a dose-dependent modulation of pro-inflammatory cytokines...
  45. ncbi Mannose-binding lectin (MBL) in health and disease
    M W Turner
    Immunobiology Unit, Institute of Child Health, London, UK
    Immunobiology 199:327-39. 1998
    ..receptors on phagocyte surface or may trigger the activation of a pro-serine protease complex (MASP 1 and MASP 2) leading to cleavage of C4 and C2 of the classical complement pathway...
  46. ncbi Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL
    N M Thielens
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat á l Energie Atomique Centre National de la Recherche Scientifique, Grenoble, France
    J Immunol 166:5068-77. 2001
    ..In human serum, two MBL-associated serine proteases (MASP-1, MASP-2) and MBL-associated protein 19 (MAp19) were found to be associated with MBL...
  47. ncbi Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55
    Florence Teillet
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, Grenoble, France
    J Immunol 178:5710-6. 2007
    ..forms complexes with MBL-associated serine proteases (MASP)-1, -2, and -3 and 19-kDa MBL-associated protein (MAp19), and triggers the complement lectin pathway through activation of MASP-2...
  48. ncbi The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases
    Florence Teillet
    Laboratoires d Enzymologie Moléculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l énergie atomique Centre National de La Recherche Scientifique Université Joseph Fourier, Grenoble, France
    J Immunol 174:2870-7. 2005
    ..forms individual complexes with MBL-associated serine proteases (MASP)-1, -2, -3 and a truncated form of MASP-2 (MAp19) and triggers the lectin pathway of complement through MASP-2 activation...
  49. ncbi Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds
    Nicholas J Lynch
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 174:4998-5006. 2005
    ..either mannan-binding lectin (MBL) or a ficolin), three MBL-associated serine proteases (MASP-1, -2, and -3), and MAp19 (a truncated product of the MASP-2 gene)...
  50. pmc Influence of major surgery on the mannan-binding lectin pathway of innate immunity
    H Ytting
    Department of Surgical Gastroenterology 435, Hvidovre University Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Clin Exp Immunol 144:239-46. 2006
    ..59, P = 0.001) and IL-6 (r = 0.55, P = 0.02) in cohort 2 only. In contrast to the marked effects on the levels of IL-6 and CRP, the surgery influenced only marginally the two proteins of the MBL pathway...
  51. ncbi Mannan-binding lectin (MBL) in women with tumours of the reproductive system
    A St Swierzko
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Łódź, Poland
    Cancer Immunol Immunother 56:959-71. 2007
    ..However, it cannot be excluded that mbl-2 mutant alleles may be in linkage disequilibrium with an unidentified tumour susceptibility gene(s)...
  52. pmc Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults
    Maciej Cedzynski
    Laboratory of Immunobiology of Infections, Center of Medical Biology, Polish Academy of Sciences, Łódź, Poland
    Arch Immunol Ther Exp (Warsz) 56:69-75. 2008
    ....
  53. ncbi Second-generation nanofiltered plasma-derived mannan-binding lectin product: process and characteristics
    I Laursen
    Statens Serum Institut, Copenhagen, Denmark
    Vox Sang 92:338-50. 2007
    ..Following is a description of the development of a nanofiltered second-generation MBL product from Cohn fraction III, with the use of a new affinity matrix for MBL purification and the characteristics of this improved product...
  54. ncbi Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations
    R Wallis
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 275:30962-9. 2000
    ..Analysis of MASP binding by rat MBP containing naturally occurring mutations equivalent to those associated with human immunodeficiency indicates that binding to both truncated MASP-1 and MASP-2 proteins is defective in such mutants...
  55. pmc Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin
    Wei Chuan Chang
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Biochem Pharmacol 81:388-95. 2011
    ..These results are encouraging that novel RCLs could be used as anti-IAV agents with less side effect and that RCLs would be suitable candidates in developing a new anti-IAV therapy...
  56. pmc Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome
    Bristol Sorensen
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, United States of America
    Mol Med 15:34-42. 2009
    ..At 1 hour postexercise, C4, mannan-binding lectin serine protease 2 (MASP2) and ficolin 1 (FCN1) transcripts were detected at higher levels (> or = 2-fold) in at least 50% (4 of 8) of ..
  57. ncbi A novel mannose-binding lectin-associated serine protease 1/3 gene variant
    G Weiss
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 65:430-4. 2007
    ..with three different serine proteases (MASP-1, MASP-2 and MASP-3) and a truncated non-enzymatic form of MASP-2 (sMAP)...
  58. pmc A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    Mikkel Ole Skjoedt
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:8234-43. 2010
    ..1 and 2, respectively) are splice variants of the MASP1 gene, whereas MASP-2 and sMAP are splice variants of the MASP2 gene. We have identified a novel serum protein of 45 kDa that is associated with MBL and the ficolins...
  59. pmc Isolation, cloning and functional characterization of porcine mannose-binding lectin
    A Agah
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunology 102:338-43. 2001
    ..Taken together, these data demonstrate that porcine and human MBL are highly conserved, sharing structural and functional characteristics...
  60. doi Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels
    Nannette Brouwer
    Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 183:3496-504. 2009
    ....
  61. doi Characterization of the complex between mannose-binding lectin trimer and mannose-binding lectin-associated serine proteases
    Koichiro Tateishi
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa
    Microbiol Immunol 55:427-33. 2011
    ..complexed with three types of serine proteases (MASP-1, MASP-2 and MASP-3) and two types of their truncated forms (sMAP and MAp44)...
  62. ncbi Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation
    Russell Wallis
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:14065-73. 2004
    ..Thus, the effect of the mutations is to destabilize the collagen-like domain, indirectly disrupting the binding sites for MASPs. In addition, at least one of the mutations has a further effect on the ability of MBP to activate MASPs...
  63. doi Ficolins: novel pattern recognition molecules of the innate immune response
    Valeria L Runza
    Institute of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Immunobiology 213:297-306. 2008
    ..When comparing ficolin orthologues from different species, it appears evident that human, murine, and porcine ficolins differ in many aspects, a specific point that we aim to address in this review...
  64. ncbi Mannan-binding lectin (MBL) in chickens: molecular and functional aspects
    S B Laursen
    Department D, Odense University Hospital, DK 5000, Odense C, Denmark
    Dev Comp Immunol 24:85-101. 2000
    ..e. mouse and rat) have two MBL forms in serum. MBL has been extensively studied in mammals but recently also in Aves. This review summarizes the present knowledge of MBL in chickens and compares it to the situation in mammals...
  65. doi Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation
    Maria A Halili
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Biochemistry 48:8466-72. 2009
    ..Complement component 2 bound to C4b is cleaved by classical (C1s) or lectin (MASP2) proteases to produce C4bC2a, a very short-lived C3 convertase (t(1/2) 2 min) that in turn cleaves C3 to C3a and ..
  66. pmc Biological activities of C1 inhibitor
    Alvin E Davis
    Harvard Medical School, Immune Disease Institute, Boston, MA 02115, USA
    Mol Immunol 45:4057-63. 2008
    ..however, are exerted via several activities including inhibition of complement system proteases (C1r, C1s, MASP2) and the plasma kallikrein-kinin system proteases, in addition to interactions with a number of different proteins,..
  67. ncbi Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 175:6846-51. 2005
    ..Analogous molecular defects in human MBL probably combine to create the mutant phenotypes of immunodeficient individuals...
  68. pmc Depressed activation of the lectin pathway of complement in hereditary angioedema
    L Varga
    3rd Department of Internal Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    Clin Exp Immunol 153:68-74. 2008
    ..0001) in healthy controls, but there was no significant correlation in the HAE patients. We conclude that the activation of LP might also occur in subjects with C1INH deficiency, which is reflected by the low MASP-2 and C4 levels...
  69. doi Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Arhus C, Denmark
    J Immunol Methods 361:37-50. 2010
    ..circulate in complexes with MBL-associated serine proteases (MASP-1, -2 and -3) and two additional proteins (MAp19 and MAp44, also termed sMAP and MAP-1, respectively)...
  70. ncbi cFKBP/SMAP; a novel molecule involved in the regulation of smooth muscle differentiation
    K Fukuda
    Hirohashi Cell Configuration Project, ERATO, Tsukuba Research Consortium, Tsukuba, Japan
    Development 125:3535-42. 1998
    ..and from the function of this protein it was designated chicken FKBP/smooth muscle activating protein (cFKBP/SMAP)...
  71. pmc Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
    Barbro Selander
    Institute of Laboratory Medicine, Section of Microbiology, Immunology, and Glycobiology, Lund University, Lund, Sweden
    J Clin Invest 116:1425-34. 2006
    ..MBL-dependent C2 bypass activation could be particularly important in various inherited and acquired complement deficiency states...
  72. pmc Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
    József Dobó
    Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e20036. 2011
    ....
  73. pmc Pyriform spidroin 1, a novel member of the silk gene family that anchors dragline silk fibers in attachment discs of the black widow spider, Latrodectus hesperus
    Eric Blasingame
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, USA
    J Biol Chem 284:29097-108. 2009
    ..MS/MS analysis also confirmed the presence of MaSp1 and MaSp2, two important components of dragline silks, anchored within the attachment disc materials...
  74. pmc Engineering novel complement activity into a pulmonary surfactant protein
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, UK
    J Biol Chem 285:10546-52. 2010
    ..Thus, the active rather than the zymogen state is default in lectin.MASP complexes and must be inhibited through additional regions in circulating MBLs until triggered by pathogen recognition...
  75. ncbi Molecular cloning of the complement (C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    M Nakao
    Laboratory of Marine Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    Immunogenetics 52:255-63. 2001
    ..Here we describe two distinct C1r/C1s/MASP2-like cDNA clones (C1r/s-A, C1r/s-B) isolated from the common carp (Cyprinus carpio)...
  76. pmc SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network
    Waka Natsume
    Department of Molecular Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Mol Biol Cell 17:2592-603. 2006
    ..Thus, the SMAP gene family constitutes an important ArfGAP subfamily, with each SMAP member exerting both common and distinct ..
  77. ncbi Antimicrobial activity of SMAP-29 against the Bacteroides fragilis group and clostridia
    Alessandra Arzese
    Institute of Microbiology, Udine Medical School, University of Udine, p zza S M Misericordia 1, 33100 Udine, Italy
    J Antimicrob Chemother 52:375-81. 2003
    The cathelicidin-derived peptide SMAP-29 exerts rapid and broad-spectrum antimicrobial activity against aerobic bacteria and fungi...
  78. pmc Chromosome mapping of dragline silk genes in the genomes of widow spiders (Araneae, Theridiidae)
    Yonghui Zhao
    Department of Biology, University of California Riverside, Riverside, California, USA
    PLoS ONE 5:e12804. 2010
    ..Dragline silk is composed of two structural proteins, MaSp1 and MaSp2, which are encoded by members of the spidroin gene family...
  79. ncbi Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis
    Fumiko Y Yoshizaki
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113 0033, Japan
    Immunogenetics 56:930-42. 2005
    ....
  80. ncbi Heterogeneity of MBL-MASP complexes
    Karine R Mayilyan
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Roads, Oxford OX1 3QU, UK
    Mol Immunol 43:1286-92. 2006
    ..The findings are consistent with separate populations of MBL-MASP-1 complexes and MBL-MASP-2 complexes, the concentrations of which show wide inter-individual variation...
  81. ncbi Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise
    H Ytting
    Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 66:458-64. 2007
    ..Circulating levels of MBL and MASP-2 are stable over time in healthy individuals, which is advantageous for their potential application as biomarkers...
  82. ncbi Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Wilhelms Meyers Allé, 8000 Aarhus C, Denmark
    Mol Immunol 44:3875-88. 2007
    ..three MBL-associated serine proteases (MASPs), MASP-1, MASP-2 and MASP-3, and a smaller MBL-associated protein (MAp19). The four recognition molecules recognize patterns of carbohydrate or acetyl-group containing ligands...
  83. pmc Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage
    Mary C Walsh
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    J Immunol Methods 323:147-59. 2007
    ..The FLISA can be used potentially to identify specific human disease correlations between these components and clinical outcomes in already established databases...
  84. pmc The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement
    Vengadesan Krishnan
    Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Biol 367:224-33. 2007
    ..these convertases requires the Mg(2+)-dependent binding of C2 to C4b, and the subsequent cleavage of C2 by C1s or MASP2, respectively...
  85. doi A SMAP gene family encoding ARF GTPase-activating proteins and its implication in membrane trafficking
    Kenji Tanabe
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Methods Enzymol 438:155-70. 2008
    SMAP1 and SMAP2 proteins constitute a subfamily of the Arf-specific GTPase-activating proteins. Both SMAP proteins bind to clathrin heavy chains and are involved in the trafficking of clathrin-coated vesicles...
  86. ncbi Multiple recombining loci encode MaSp1, the primary constituent of dragline silk, in widow spiders (Latrodectus: Theridiidae)
    Nadia A Ayoub
    Department of Biology, University of California, Riversid, USA
    Mol Biol Evol 25:277-86. 2008
    ..Because of its remarkable mechanical properties, orb weaver dragline silk, a composite of 2 proteins (MaSp1 and MaSp2), is the best studied. Here, we demonstrate that multiple loci encode MaSp1 in widow spiders (Latrodectus)...
  87. ncbi Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 282:7844-51. 2007
    ....
  88. ncbi Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy
    M Endo
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 13:1984-90. 1998
    ..The present study was undertaken to elucidate whether the lectin pathway was involved in the pathogenic mechanism of IgA-N...
  89. ncbi Opsonic complement system of the solitary ascidian, Halocynthia roretzi
    M Nonaka
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Dev Comp Immunol 23:421-7. 1999
    ..These results indicate that the lectin-dependent, opsonic complement system was present prior to the emergence of the vertebrates and well ahead of the establishment of adaptive immunity...
  90. ncbi Antifungal mechanism of SMAP-29 (1-18) isolated from sheep myeloid mRNA against Trichosporon beigelii
    Dong Gun Lee
    Research Center for Proteineous Materials RCPM, Chosun University, 375 Seosuk dong, Dong Ku, Kwangju 501 759, Republic of Korea
    Biochem Biophys Res Commun 295:591-6. 2002
    The antifungal activity and mechanism of SMAP-29 (1-18) (SMAP-29), a cathelicidin-derived antimicrobial peptide deduced from N-terminal sequence of sheep myeloid mRNA, were investigated...
  91. ncbi Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter
    Yuichi Endo
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int Immunol 14:1193-201. 2002
    ..The stimulatory effects of IL-1beta on MASP1/3 and MASP2 gene expression were abolished by the simultaneous presence of IL-6...
  92. ncbi Human M-ficolin is a secretory protein that activates the lectin complement pathway
    Yu Liu
    Department of Immunology, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Japan
    J Immunol 175:3150-6. 2005
    ..These results indicate that M-ficolin, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity...
  93. doi Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults
    M Isabel Garcia-Laorden
    Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
    J Allergy Clin Immunol 122:368-74, 374.e1-2. 2008
    ..MBL is a serum lectin that mediates phagocytosis and activates the lectin pathway of complement involving MASP-2...
  94. doi Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:551-8. 2009
    ..Some similar trends were found with facets of MBL deficiency, but the observed relationships were weaker and less consistent...
  95. doi Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)
    Aina Zehnder
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Blood Cancer 53:53-7. 2009
    ..Their serum concentrations show a wide interindividual variability. This study investigated whether the concentration of MBL and MASP-2 is associated with prognosis in pediatric patients with cancer...
  96. pmc SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison
    Jingyuan Ren
    San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nucleic Acids Res 38:W441-4. 2010
    ..The SMAP web service (SMAP-WS) meets this need through parallel computations designed for 3D ligand-binding site comparison ..
  97. pmc Nanostructure and molecular mechanics of spider dragline silk protein assemblies
    Sinan Keten
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, USA
    J R Soc Interface 7:1709-21. 2010
    ..Here, we report atomic-level structures of MaSp1 and MaSp2 proteins from the Nephila clavipes spider dragline silk sequence, obtained using replica exchange molecular ..
  98. doi Prey type, vibrations and handling interactively influence spider silk expression
    S J Blamires
    Department of Life Sciences, Tunghai University, Taichung, Taiwan
    J Exp Biol 213:3906-10. 2010
    ..MA) silks vary in response to different prey, mostly via differential expression of two genes - MaSp1 and MaSp2 - although the spinning process exerts additional influence over the mechanical properties of silk...
  99. pmc Carbohydrate recognition and complement activation by rat ficolin-B
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Eur J Immunol 41:214-23. 2011
    ..Mutagenesis data reveal that lack of activity in mouse ficolin-B is probably caused by a single amino acid change in the putative MASP-binding site that blocks the ficolin-MASP interaction...
  100. doi Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?
    Tang Yongqing
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Biochim Biophys Acta 1824:253-62. 2012
    ..during expression to yield 5 proteins, including three proteases (MASP-1, -2 and -3) and two truncated proteins, MAp19 and MAp44. Here we discuss what is currently known about these proteins in terms of their structure and function...
  101. pmc Studies of the pattern recognition molecule H-ficolin: specificity and purification
    Rikke M Zacho
    Department of Medical Microbiology and Immunology, Aarhus University, 8000 Aarhus, Denmark
    J Biol Chem 287:8071-81. 2012
    ..This study extends our knowledge of the specificity of this pattern recognition molecule, and the purified product will enable further studies...

Research Grants16

  1. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
    ..Studies will be conducted in mice deficient in MASP-2 to determine their susceptibility to AMD and would provide support for this as a novel target in AMD medication development. [unreadable] [unreadable] [unreadable]..
  2. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
    ....
  3. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    ..Our work would also expand the concept of "serotype" to include serotype specific interactions with innate opsonins, as well as antibodies, and this new concept may bring further innovations in vaccine designs against many pathogens. ..
  4. MASP-2 MoAB therapeutics for MI/RP injury
    CLARK TEDFORD; Fiscal Year: 2005
    ..In this Phase 1 study our specific objectives are to compare cardio and inflammatory functional outcomes when both MASP-2 (-/-) and matched MASP(+/+) mice are evaluated in a murine model of MIRP. ..
  5. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
    ..1 will test the hypothesis that mutations in the collagen region of MBL alter binding interactions with MASP1 or MASP2 and result in dysfunctional complement activation and/or disruption of MBL-mediated phagocytosis...
  6. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Tis rojectseekstoexlore heuseo-fMaSniP-2 atioytherayto revet ortrea eroahiccomlicaiosofdiaees. ..
  7. Cellular Mapping of Small Molecule/Nucleic Acid Interactions
    Micah J Bodner; Fiscal Year: 2012
    ..This approach, small molecule affinity purification and sequencing (SMAP-seq), may find application as a general protocol for investigations of small molecule-nucleic acid interactions...
  8. Development of MASP-2 MoAbs for the treatment of diabetic nephropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2010
    ..The objective of this proposal is to develop anti-MASP-2 monoclonal antibodies which specifically block the lectin pathway of the complement system as a novel therapeutic to prevent and treat the renal complications of diabetes. ..
  9. StcE, an E.coli O157:H7 Protease Specific for C1-Inh
    RODNEY WELCH; Fiscal Year: 2007
    ..The elucidation of StcE structure and function(s) may result in new targets for chemotherapeutic or immune prevention or treatment of EHEC infections, which now are best managed only by supportive therapy. ..
  10. Development of Zebrafish Enteric Nervous System and Intestinal Smooth Muscle
    KENNETH WALLACE; Fiscal Year: 2007
    ..Specific aim 2 tests the hypothesis that the zebrafish homologue of zFKBP/SMAP and BMP signaling are critical for development of enteric and intestinal smooth muscle...
  11. MASP-2: A Potential New Target for Treatment of Rheumatoid Arthritis
    Emma Moore; Fiscal Year: 2008
    ..Results from these studies should demonstrate whether MASP-2 is a promising novel target for the treatment of RA. [unreadable] [unreadable] [unreadable]..
  12. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001
    ..abstract_text> ..
  13. REGULATION OF C1 INHIBITOR SYNTHESIS
    Alvin Davis; Fiscal Year: 2004
    ..The studies proposed here will contribute both to knowledge of the regulation of C1INH itself and to the role of hormones, nuclear phosphatases and Pu-Py sequences on gene regulation in general. ..
  14. C1 INHIBITOR GENE AND HEREDITARY ANGIONEUROTIC EDEMA
    Alvin Davis; Fiscal Year: 2008
    ..abstract_text> ..
  15. C1 INHIBITOR-MEDIATED PROTECTION FROM ENDOTOXIN SHOCK
    Alvin Davis; Fiscal Year: 2009
    ..These studies will lead to improved understanding of the role played by C1INH in the cbrresistance to gram negative sepsis and endotoxin shock, and may lead to new therapies for these diseases. ..
  16. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..Possible applications of spider silk range from artificial ligaments and tendons to bandages for burns to composite materials for multiple applications. ..