MASP1

Summary

Gene Symbol: MASP1
Description: mannan binding lectin serine peptidase 1
Alias: 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan-binding lectin serine protease 1, C4/C2 activating component of Ra-reactive factor, Ra-reactive factor serine protease p100, complement factor MASP-3, complement-activating component of Ra-reactive factor, mannose-binding lectin-associated serine protease 1, mannose-binding protein-associated serine protease, serine protease 5
Species: human
Products:     MASP1

Top Publications

  1. Dahl M, Thiel S, Matsushita M, Fujita T, Willis A, Christensen T, et al. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity. 2001;15:127-35 pubmed
    ..We present a phylogenetically highly conserved member of the MBL complex, MASP-3, which is generated through alternative splicing of the MASP-1/3 gene...
  2. Krarup A, Gulla K, Gal P, Hajela K, Sim R. The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen. Biochim Biophys Acta. 2008;1784:1294-300 pubmed publisher
    ..lectin (MBL) or the ficolins and the subsequent activation of the MBL-associated serine proteases (MASPs), namely, MASP1, 2 and 3 which all form complexes with both MBL and the ficolins...
  3. Dobó J, Harmat V, Beinrohr L, Sebestyén E, Zavodszky P, Gal P. MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J Immunol. 2009;183:1207-14 pubmed publisher
    Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 is an abundant component of the lectin pathway of complement. The related enzyme, MASP-2 is capable of activating the complement cascade alone...
  4. Megyeri M, Makó V, Beinrohr L, Doleschall Z, Prohaszka Z, Cervenak L, et al. Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function. J Immunol. 2009;183:3409-16 pubmed publisher
    ..Mannose-binding lectin-associated serine protease-1 (MASP-1) is an abundant protease of the complement lectin pathway; however, its physiological function is unclear...
  5. Kocsis A, Kekesi K, Szasz R, Végh B, Balczer J, Dobó J, et al. Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. J Immunol. 2010;185:4169-78 pubmed publisher
    ..peptide inhibitors developed by phage display against mannose-binding lectin-associated serine proteases (MASPs), MASP-1 and MASP-2...
  6. Sirmaci A, Walsh T, Akay H, Spiliopoulos M, Sakalar Y, Hasanefendioğlu Bayrak A, et al. MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes. Am J Hum Genet. 2010;87:679-86 pubmed publisher
    ..In one family, whole exome sequencing revealed a missense mutation, MASP1 c.2059G>A (p.G687R), that cosegregated with the phenotype...
  7. Thiel S, Jensen L, Degn S, Nielsen H, Gal P, Dobó J, et al. Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clin Exp Immunol. 2012;169:38-48 pubmed publisher
    ..Three proteins are produced from the MASP1 gene: MASP-1 and MASP-3 and MAp44. We present an assay specific for MASP-1, which is based on inhibition of the binding of anti-MASP-1-specific ..
  8. Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, et al. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol. 2012;189:3957-69 pubmed publisher
    ..study, we present functional studies based on a patient harboring a nonsense mutation in the common part of the MASP1 gene and hence deficient in both MASP-1 and MASP-3...
  9. Rossi V, Cseh S, Bally I, Thielens N, Jensenius J, Arlaud G. Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2. J Biol Chem. 2001;276:40880-7 pubmed
    Mannan-binding lectin (MBL)-associated serine proteases-1 and 2 (MASP-1 and MASP-2) are homologous modular proteases that each interact with MBL, an oligomeric serum lectin involved in innate immunity...

More Information

Publications106 found, 100 shown here

  1. Møller Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius J. Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int Immunol. 2007;19:141-9 pubmed
    ..lectin (MBL) promoted the activation of C3 through the combined action of MBL-associated serine protease (MASP)-1 and MASP-2 without appreciable involvement of the alternative pathway...
  2. Degn S, Hansen A, Steffensen R, Jacobsen C, Jensenius J, Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol. 2009;183:7371-8 pubmed publisher
    ..We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1...
  3. Skjoedt M, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, et al. A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J Biol Chem. 2010;285:8234-43 pubmed publisher
    ..MASP-1 and MASP-3 (MASP1 isoforms 1 and 2, respectively) are splice variants of the MASP1 gene, whereas MASP-2 and sMAP are splice variants ..
  4. Degn S, Jensen L, Gal P, Dobó J, Holmvad S, Jensenius J, et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods. 2010;361:37-50 pubmed publisher
    ..MASP-1, MASP-3 and MAp44 are all three encoded by the MASP1 gene...
  5. Rooryck C, Diaz Font A, Osborn D, Chabchoub E, Hernandez Hernandez V, Shamseldin H, et al. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet. 2011;43:197-203 pubmed publisher
    ..Here we studied 11 families with 3MC syndrome and identified two mutated genes, COLEC11 and MASP1, both of which encode proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 and MASP-3, ..
  6. Dobó J, Major B, Kekesi K, Szabo I, Megyeri M, Hajela K, et al. Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1. PLoS ONE. 2011;6:e20036 pubmed publisher
    ..system activates after infection and oxidative stress on endothelial cells generating active serine proteases: MASP-1 and MASP-2. Our aim was to study whether activated MASPs are able to digest HK to release BK...
  7. Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kekesi K, et al. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem. 2012;287:20290-300 pubmed publisher
    ..b>MASP-2 is considered as the autonomous pathway-activator, while MASP-1 is considered as an auxiliary component...
  8. Héja D, Kocsis A, Dobó J, Szilágyi K, Szasz R, Zavodszky P, et al. Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2. Proc Natl Acad Sci U S A. 2012;109:10498-503 pubmed publisher
    ..Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)-2 has been considered the autonomous initiator of the proteolytic cascade...
  9. Ambrus G, Gal P, Kojima M, Szilágyi K, Balczer J, Antal J, et al. Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments. J Immunol. 2003;170:1374-82 pubmed
    Mannan-binding lectin-associated serine protease (SP) (MASP)-1 and MASP-2 are modular SP and form complexes with mannan-binding lectin, the recognition molecule of the lectin pathway of the complement system...
  10. Megyeri M, Harmat V, Major B, Végh A, Balczer J, Héja D, et al. Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway. J Biol Chem. 2013;288:8922-34 pubmed publisher
    Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have been thought to autoactivate when MBL/ficolin·MASP complexes bind to pathogens triggering the complement lectin pathway...
  11. Hansen S, Ohtani K, Roy N, Wakamiya N. The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity. Immunobiology. 2016;221:1058-67 pubmed publisher
    ..Deficiency of either CL-K1 or MASP-3 has been demonstrated in 3MC syndrome patients with developmental abnormalities, showing that lectin pathway ..
  12. Fraser R, Arroyo L, Meyer A, Lillie B. Identification of genetic variation in equine collagenous lectins using targeted resequencing. Vet Immunol Immunopathol. 2018;202:153-163 pubmed publisher
    ..and downstream (approximately 3 kb) regulatory regions for the 11 equine collagenous lectin genes and related MASP genes were targeted for re-sequencing...
  13. Mortensen S, Skov L, Kjaer Sorensen K, Hansen A, Hansen S, Dagnæs Hansen F, et al. Endogenous Natural Complement Inhibitor Regulates Cardiac Development. J Immunol. 2017;198:3118-3126 pubmed publisher
    ..Knockdown of embryonic expression of MAp44 caused impaired cardiogenesis, lowered heart rate, and decreased cardiac output...
  14. Bobka S, Ebert N, Koertvely E, Jacobi J, Wiesener M, Büttner Herold M, et al. Is Early Complement Activation in Renal Transplantation Associated with Later Graft Outcome?. Kidney Blood Press Res. 2018;43:1488-1504 pubmed publisher
    ..Moreover, glomerular C3c and C9 and tubular MASP-2 and Collectin-11 expression in zero-biopsies significantly correlated with serum creatinine at diagnosis of DGF, ..
  15. Man Kupisinska A, Michalski M, Maciejewska A, Swierzko A, Cedzynski M, Lugowski C, et al. A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins. PLoS ONE. 2016;11:e0156691 pubmed publisher
    ..Thus our purification procedure provides Ig-ficolin-3/MASP complexes that might be useful for gaining further insight into the crosstalk and biological activity of ficolin-3. ..
  16. Osthoff M, Wójtowicz A, Tissot F, Jørgensen C, Thiel S, Zimmerli S, et al. Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland. J Infect. 2016;72:377-85 pubmed publisher
    ..4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4...
  17. Cervera A, Planas A, Justicia C, Urra X, Jensenius J, Torres F, et al. Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS ONE. 2010;5:e8433 pubmed publisher
    ..In order to investigate the clinical relevance of these experimental observations, a study of MBL2 and MASP-2 gene polymorphism rendering the lectin pathway dysfunctional was performed in 135 stroke patients...
  18. Nicola F, Loriano B. Morula cells as key hemocytes of the lectin pathway of complement activation in the colonial tunicate Botryllus schlosseri. Fish Shellfish Immunol. 2017;63:157-164 pubmed publisher
    ..e., genes for a mannose-binding lectin (MBL), a ficolin and a mannose-associated serine protease 1 (MASP1)...
  19. Elisei R, Matos C, Carvalho A, Chaves A, Medeiros F, Barbosa R, et al. Immunogenomic screening approach to identify new antigens for the serological diagnosis of chronic Chagas' disease. Appl Microbiol Biotechnol. 2018;102:6069-6080 pubmed publisher
    ..Three B-cell epitopes derived from mucin-associated surface protein (MASP) family, expressed in both infective parasite stages, trypomastigote and amastigotes, conserved in T...
  20. Farrar C, Tran D, Li K, Wu W, Peng Q, Schwaeble W, et al. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest. 2016;126:1911-25 pubmed publisher
    ..Further analysis revealed that cell-bound CL-11 required the lectin complement pathway-associated protease MASP-2 to trigger complement deposition...
  21. Choteau L, Vasseur F, Lepretre F, Figeac M, Gower Rousseau C, Dubuquoy L, et al. Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients. Sci Rep. 2016;6:29636 pubmed publisher
    ..a low level of mannose-binding lectin and impaired mannose-binding lectin-mannose-associated serine protease (MBL-MASP) functional activity in Crohn's disease patients...
  22. Ribeiro C, Lynch N, Stover C, Ali Y, Valck C, Noya Leal F, et al. Deficiency in mannose-binding lectin-associated serine protease-2 does not increase susceptibility to Trypanosoma cruzi infection. Am J Trop Med Hyg. 2015;92:320-4 pubmed publisher
    ..to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2). Previous in vitro work showed that human MBL and ficolins contribute to T. cruzi lysis...
  23. Desai V, Lee T, Moland C, Vijay V, Han T, Lewis S, et al. Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice. Toxicol Appl Pharmacol. 2018;363:164-173 pubmed publisher
    ..This suggests NOTCH1 and vWF as candidate early biomarkers of DOX cardiotoxicity, which may help in addressing a clinically important question of identifying cancer patients at risk for cardiotoxicity. ..
  24. Bradwell K, Koparde V, Matveyev A, Serrano M, Alves J, Parikh H, et al. Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to Trypanosoma cruzi strains of high and low virulence. BMC Genomics. 2018;19:770 pubmed publisher
    ..e. trans-sialidases, mucins, DGF-1, and MASP, compared to T. cruzi. Our analyses of the T. rangeli and T...
  25. Tao X, Zheng S, Lei B. [Alternation of retinal complement system in a mouse model of lipopolysaccharide- induced uveitis]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34:1121-4 pubmed
    ..Although MASP1 and MASP2 were detected in the retina in both the EIU and control groups, their expressions were weak and showed ..
  26. Köse K, Köse D. Removal of DDE by exploiting the alcoho-phobic interactions. Environ Sci Pollut Res Int. 2017;24:9187-9193 pubmed publisher
    ..on the development of aspartic acid-incorporated poly(2-hydroxyethyl methacrylate-L-aspartic acid) [poly(HEMA-MAsp)] cryogel for the removal of DDE from aqueous solutions for the first time in the literature...
  27. Rajeevan M, Dimulescu I, Murray J, Falkenberg V, Unger E. Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome. Hum Immunol. 2015;76:553-60 pubmed publisher
    ..Some of these SNPs were in genes within pathways related to complement cascade (SERPINA5, CFB, CFH, MASP1 and C6), chemokines (CXCL16, CCR4, CCL27), cytokine signaling (IL18, IL17B, IL2RB), and toll-like receptor ..
  28. Kiely A, Murray C, Foti S, Benson B, Courtney R, Strand C, et al. Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain. J Neuropathol Exp Neurol. 2018;77:598-607 pubmed publisher
    ..Decreased expression of CX3CL1 precursor protein and significantly greater CX3CR1 protein was found in MSA. NanoString analysis revealed the >2-fold greater expression of ARG1, MASP1, NOX4, PTGDR2, and C6 in MSA.
  29. Goshima M, Sekiguchi R, Matsushita M, Nonaka M. The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena. Dev Comp Immunol. 2016;61:13-24 pubmed publisher
    ..Identified genes were; one C1qB, one C1r, one C1s, one MASP-1/-3, one MASP-2, two factor B/C2, one C3, three C4, one C5, one C6, one C7, one C8A, three C8B, one C8G, one C9, ..
  30. Riet J, Ramos L, Lewis R, Marins L. Improving the PCR protocol to amplify a repetitive DNA sequence. Genet Mol Res. 2017;16: pubmed publisher
    ..These megaprimers anneal with other sequences, generating unexpected fragments in each PCR cycle. Our gene model, MaSp1, is 1037-bp long, with 68% GC content, and its amino acid sequence is characterized by poly-alanine-glycine motifs,..
  31. Larracas C, Hekman R, Dyrness S, Arata A, Williams C, Crawford T, et al. Comprehensive Proteomic Analysis of Spider Dragline Silk from Black Widows: A Recipe to Build Synthetic Silk Fibers. Int J Mol Sci. 2016;17: pubmed publisher
    ..of spider dragline silk fibers have been attributed to two spidroins, major ampullate spidroins 1 and 2 (MaSp1 and MaSp2)...
  32. Oroszlán G, Kortvely E, Szakács D, Kocsis A, Dammeier S, Zeck A, et al. MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. J Immunol. 2016;196:857-65 pubmed publisher
    ..The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has markedly reduced alternative pathway activity...
  33. Plakornkul V, Vannabhum M, Viravud Y, Roongruangchai J, Mutirangura P, Akarasereenont P, et al. The effects of the court-type Thai traditional massage on anatomical relations, blood flow, and skin temperature of the neck, shoulder, and arm. BMC Complement Altern Med. 2016;16:363 pubmed publisher
    Court-type Thai traditional massage (CTTM) has specific major signal points (MaSP) for treating musculoskeletal conditions...
  34. Østergaard J, Thiel S, Hoffmann Petersen I, Hovind P, Parving H, Tarnow L, et al. Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes. Diabetes Metab Res Rev. 2017;33: pubmed publisher
    ..by pattern-recognition molecules, eg, mannan-binding lectin (MBL), the MBL-associated serine protease (MASP-2) is activated and initiates the complement cascade...
  35. Li J, Zhu L, Zuo D, Zhang L, Lu X, Chen Z, et al. [Plasma mannan?binding lectin and MBL?associated serine protease 2 in patients with hepatocellular carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1667-1672 pubmed
    To detect the plasma levels of mannan?binding lectin (MBL) and MBL?associated serine protease?2 (MASP-2) in patients with hepatocellular carcinoma (HCC) and explore their role in the tumorigenesis and progression of HCC...
  36. Thiel S, Petersen S, Vorup Jensen T, Matsushita M, Fujita T, Stover C, et al. Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. J Immunol. 2000;165:878-87 pubmed
    ..C1r and C1s were initially discovered in a complex with C1q, whereas the MBL-associated serine proteases 1 and 2 (MASP-1 and -2) were discovered in a complex with MBL...
  37. Gopalakrishnan A, Maji C, Dahiya R, Suthar A, Kumar R, Gupta A, et al. In vitro growth inhibitory efficacy of some target specific novel drug molecules against Theileria equi. Vet Parasitol. 2016;217:1-6 pubmed publisher
    ..A continuous microaerophilic stationary-phase culture (MASP) system was established for propagation of T. equi parasites...
  38. Munye M, Diaz Font A, Ocaka L, Henriksen M, Lees M, Brady A, et al. COLEC10 is mutated in 3MC patients and regulates early craniofacial development. PLoS Genet. 2017;13:e1006679 pubmed publisher
    ..We previously reported that lectin complement pathway genes COLEC11 and MASP1/3 are mutated in 3MC syndrome patients...
  39. Mayilyan K, Presanis J, Arnold J, Hajela K, Sim R. Heterogeneity of MBL-MASP complexes. Mol Immunol. 2006;43:1286-92 pubmed
    In order to study aspects of the stoichiometry and composition of human MBL-MASP complexes in the population, MBL-MASP complexes were bound from sera of 152 healthy individuals onto mannan-coated microtitre plates...
  40. Smedbråten J, Mjøen G, Hartmann A, Asberg A, Rollag H, Mollnes T, et al. Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients. BMC Nephrol. 2016;17:148 pubmed
    ..MBL) associated proteases, MASP-2 and MASP-3 (activators of the lectin pathway) and two MBL-associated proteins, MAp44 and MAp19 (inhibitors of the lectin pathway) were measured at the time of transplantation in 382 patients (?17 ..
  41. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and ..
  42. Świerzko A, Szala Poździej A, Kilpatrick D, Sobociński M, Chojnacka K, Sokołowska A, et al. Components of the lectin pathway of complement activation in paediatric patients of intensive care units. Immunobiology. 2016;221:657-69 pubmed publisher
    ..controls but no significant differences in the frequency of SNPs of other lectin pathway genes (FCN1, FCN2, FCN3, MASP1/3, MASP2) or TLR receptor genes (TLR2, TLR4) were found...
  43. Bauer J, Scheibel T. Conformational Stability and Interplay of Helical N- and C-Terminal Domains with Implications on Major Ampullate Spidroin Assembly. Biomacromolecules. 2017;18:835-845 pubmed publisher
    ..Here, the conformational stability of NRN1 and NRC1 of Latrodectus hesperus MaSp1 were studied using independent techniques such as circular dichroism, fluorescence and absorbance spectroscopy, ..
  44. Segarra Medrano A, Carnicer Cáceres C, Valtierra Carmeno N, Agraz Pamplona I, Ramos Terrades N, Jatem Escalante E, et al. Study of the variables associated with local complement activation in IgA nephropathy. Nefrologia. 2017;37:320-329 pubmed publisher
    ..Renal lesions were quantified using the Oxford classification. Immunohistochemical staining for MBL, MASP-2, properdin, C4d, and C5b-9 was performed in kidney biopsies, and in urine, the levels of properdin, MBL, C4d and ..
  45. Takada F, Seki N, Matsuda Y, Takayama Y, Kawakami M. Localization of the genes for the 100-kDa complement-activating components of Ra-reactive factor (CRARF and Crarf) to human 3q27-q28 and mouse 16B2-B3. Genomics. 1995;25:757-9 pubmed
    ..and mouse genes for the complement-activating component (P100) of Ra-reactive factor, a novel bactericidal factor (CRARF and Crarf), were mapped to R-banded metaphase chromosomes by fluorescence in situ hybridization with human and ..
  46. Matsushita M, Thiel S, Jensenius J, Terai I, Fujita T. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J Immunol. 2000;165:2637-42 pubmed
    ..In human, two types of MBL-associated serine protease (MASP-1 and MASP-2) and a truncated protein of MASP-2 (small MBL-associated protein; sMAP or MAp19) are complexed with ..
  47. Beltrame M, Boldt A, Catarino S, Mendes H, Boschmann S, Goeldner I, et al. MBL-associated serine proteases (MASPs) and infectious diseases. Mol Immunol. 2015;67:85-100 pubmed publisher
    ..Alternative splicing of the pre-mRNA encoding MASP-1 results in two other products, MASP-3 and MAp44, which regulate activation of the cascade...
  48. Poole A, Kitchen S, Weis V. The Role of Complement in Cnidarian-Dinoflagellate Symbiosis and Immune Challenge in the Sea Anemone Aiptasia pallida. Front Microbiol. 2016;7:519 pubmed publisher
    ..Several complement molecules including C3, Factor B, and mannose binding lectin associated serine proteases (MASP) have been characterized in invertebrates and while most studies have focused on their conserved role in defense ..
  49. Graul Neumann L, Mensah M, Klopocki E, Uebe S, Ekici A, Thiel C, et al. Biallelic intragenic deletion in MASP1 in an adult female with 3MC syndrome. Eur J Med Genet. 2018;61:363-368 pubmed publisher
    ..It is caused by biallelic mutations in one of three genes, MASP1, COLEC11 and COLEC10, all encoding factors of the lectin complement pathway...
  50. Pągowska Klimek I, Świerzko A, Michalski M, Moll M, Szala Poździej A, Sokołowska A, et al. Mannose-binding lectin (MBL) insufficiency protects against the development of systemic inflammatory response after pediatric cardiac surgery. Immunobiology. 2016;221:175-81 pubmed publisher
    ..serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine proteases (MASP-1, MASP -2), in relation to complications following cardiac surgery in 195 children...
  51. Francischini J, Kemper E, Costa J, Manechini J, Pinto L. DNA methylation in sugarcane somaclonal variants assessed through methylation-sensitive amplified polymorphism. Genet Mol Res. 2017;16: pubmed publisher
    ..The MASP technique proved to be a promising tool to early assessment of genetic fidelity of micro-propagated sugarcane ..
  52. Rosbjerg A, Munthe Fog L, Garred P, Skjoedt M. Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1. J Immunol. 2014;192:4352-60 pubmed publisher
    ..Complexes containing both MAP-1 and MASP-1 or -3 were detected in normal human serum and plasma, and depletion of the LCP recognition molecules from ficolin-..
  53. Masson Lecomte A, López de Maturana E, Goddard M, Picornell A, Rava M, Gonzalez Neira A, et al. Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment. Cancer Epidemiol Biomarkers Prev. 2016;25:1144-50 pubmed publisher
    ..69; P = 1.55 × 10(-5)) and two SNPs in MASP1 and AIRE, showed a posterior probability ?80% with MMM...
  54. Kasanmoentalib E, Valls Seron M, Ferwerda B, Tanck M, Zwinderman A, Baas F, et al. Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Neuroinflammation. 2017;14:2 pubmed publisher
    ..We investigated mannose-binding lectin-associated serine protease (MASP-2) levels in cerebrospinal fluid (CSF) samples derived from the diagnostic lumbar puncture, which was available for ..
  55. Jani P, Kajdacsi E, Megyeri M, Dobó J, Doleschall Z, Futosi K, et al. MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes. PLoS ONE. 2014;9:e87104 pubmed publisher
    ..We have previously shown that mannan-binding lectin-associated serine protease-1 (MASP-1), the most abundant enzyme of the complement lectin pathway, can induce p38-MAPK activation, NFkappaB signaling, ..
  56. Endo Y, Sato T, Matsushita M, Fujita T. Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes. Int Immunol. 1996;8:1355-8 pubmed
    Mannan or mannose-binding protein (MBP) requires a novel serine protease termed MBP-associated serine protease (MASP) for activation of the complement cascade...
  57. Duus K, Thielens N, Lacroix M, Tacnet P, Frachet P, Holmskov U, et al. CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site. FEBS J. 2010;277:4956-64 pubmed publisher
    ..MBL-associated serine protease 3 (MASP-3) also inhibited binding between MBL and CD91, suggesting that the site of interaction is located at or near the ..
  58. Hess K, Ajjan R, Phoenix F, Dobó J, Gal P, Schroeder V. Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation. PLoS ONE. 2012;7:e35690 pubmed publisher
    ..Recently, links between coagulation and mannan-binding lectin-associated serine protease-1 (MASP-1) of the complement lectin pathway have been proposed...
  59. Yang Y, Wang C, Jin L, He F, Li C, Gao Q, et al. IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study. Immunol Res. 2016;64:919-30 pubmed publisher
    ..Completed remission (CR) was a major clinical outcome. A series of complement ingredients (MASP-1/2, MBL, C3a, C5a, Factor B, Ba, Bb and C5b-9) were measured in the patients of bi-positivity and bi-negativity: (..
  60. Ingels C, Vanhorebeek I, Derese I, Jensen L, Wouters P, Thiel S, et al. The pattern recognition molecule collectin-L1 in critically ill children. Pediatr Res. 2016;80:237-43 pubmed publisher
    ..to the pediatric intensive care unit (PICU) of the mannan-binding lectin (MBL)-associated serine protease (MASP)-3 protein of the lectin pathway of complement activation have been associated with risk of infection and prolonged ..
  61. Thamm C, Scheibel T. Recombinant Production, Characterization, and Fiber Spinning of an Engineered Short Major Ampullate Spidroin (MaSp1s). Biomacromolecules. 2017;18:1365-1372 pubmed publisher
    ..silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity...
  62. Pang S, Wijeyewickrema L, Hor L, Tan S, Lameignere E, Conway E, et al. The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech. J Immunol. 2017;199:3883-3891 pubmed publisher
    ..The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases...
  63. Neth O, Jack D, Dodds A, Holzel H, Klein N, Turner M. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun. 2000;68:688-93 pubmed
    ..Bound MBL was able to promote C4 deposition in a concentration-dependent manner. We conclude that MBL may be of importance in first-line immune defense against several important pathogens. ..
  64. Neth O, Jack D, Johnson M, Klein N, Turner M. Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J Immunol. 2002;169:4430-6 pubmed
    ..of the innate immune system that circulates as a complex with a group of so-called MBL-associated serine proteases (MASP-1, MASP-2, and MASP-3)...
  65. Weiss G, Madsen H, Garred P. A novel mannose-binding lectin-associated serine protease 1/3 gene variant. Scand J Immunol. 2007;65:430-4 pubmed
    ..07), which was not observed in the other groups. In conclusion, the MASP1/3 gene harbours a low-frequent polymorphic site resulting in an amino acid substitution, which may influence the ..
  66. Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud G, Thielens N. Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem. 2008;283:25715-24 pubmed publisher
    MASP-1 and MASP-3 are homologous proteases arising from alternative splicing of the MASP1/3 gene. They include an identical CUB(1)-EGF-CUB(2)-CCP(1)-CCP(2) module array prolonged by different serine protease domains at the C-terminal end...
  67. Ma Y, Skjoedt M, Garred P. Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex. J Innate Immun. 2013;5:242-50 pubmed publisher
    ..We can show that collectin-11 associates with all the known MBL-associated serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin complement pathway regulator MAP-1...
  68. Saeed A, Baloch K, Brown R, Wallis R, Chen L, Dexter L, et al. Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells. Clin Exp Immunol. 2013;174:265-73 pubmed publisher
    Mannan binding lectin (MBL)-associated serine protease type 1 (MASP-1) has a central role in the lectin pathway of complement activation and is required for the formation of C3 convertase...
  69. Megyeri M, Jani P, Kajdacsi E, Dobó J, Schwaner E, Major B, et al. Serum MASP-1 in complex with MBL activates endothelial cells. Mol Immunol. 2014;59:39-45 pubmed publisher
    ..This is in agreement with our previous results showing that the recombinant catalytic fragment of MASP-1 activates endothelial cells by cleaving protease activated receptor 4...
  70. Wu W, Yang H, Feng Y, Zhang P, Li S, Wang X, et al. Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China. Inflamm Res. 2016;65:837-45 pubmed publisher
    ..We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study of 203 ..
  71. Riekel C, Burghammer M, Dane T, Ferrero C, Rosenthal M. Nanoscale Structural Features in Major Ampullate Spider Silk. Biomacromolecules. 2017;18:231-241 pubmed publisher
    ..The precipitation of larger ?-type nanocrystallites in the outer core-shell is attributed to MaSp1 protein molecules.
  72. Alhaboubi A, He L, McCormack K, Gustafson A, Holman P. Recovery of bovine Babesia spp. after long-term cryostorage and comparison of bovine donor erythrocytes and serum. Vet Parasitol. 2017;243:109-114 pubmed publisher
    ..Four cattle were compared as donors of erythrocytes and serum for microaerophilous stationary phase (MASP) cultures for recovery of B. bigemina...
  73. Takada F, Takayama Y, Hatsuse H, Kawakami M. A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochem Biophys Res Commun. 1993;196:1003-9 pubmed
    The Ra-reactive factor (RaRF) found in vertebrate sera activates the C4 and C2 components of complement. The C4/C2-activating component of mouse RaRF has been found to contain a 100-kDa serine protease called P100...
  74. Endo M, Ohi H, Ohsawa I, Matsushita M, Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transplant. 1998;13:1984-90 pubmed
    ..activation of the complement cascade (lectin pathway) utilizing two types of MBP-associated serine protease, namely MASP-1 and MASP-2...
  75. Takayama Y, Takada F, Nowatari M, Kawakami M, Matsu ura N. Gene structure of the P100 serine-protease component of the human Ra-reactive factor. Mol Immunol. 1999;36:505-14 pubmed
    The Ra-reactive factor (RaRF) is a complement dependent anti-microbial factor that reacts with numerous microorganisms such as viruses, bacteria, fungi and protozoa...
  76. Kang J, Koo S, Kwon K, Park J, Kim J. Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung. BMC Cancer. 2009;9:237 pubmed publisher
    ..2-q29: LOC389174 (3q26.2),KCNMB3 (3q26.32),EPHB3 (3q27.1), MASP1 and SST (3q27...
  77. Gaboriaud C, Gupta R, Martin L, Lacroix M, Serre L, Teillet F, et al. The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. PLoS ONE. 2013;8:e67962 pubmed publisher
    ..A link between mutations in the MASP1/3 gene and the rare autosomal recessive 3MC (Mingarelli, Malpuech, Michels and Carnevale,) syndrome, characterized ..
  78. Song R, Zou Q, Li X, Xu N, Zhang T, Fu J, et al. Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease. Pediatr Res. 2016;79:301-7 pubmed publisher
    ..Lectin pathway-related factors MASP-1, CD59, and C5b-9 were measured, along with C-reactive protein, white blood cell counts, erythrocyte sedimentation ..
  79. Kozarcanin H, Lood C, Munthe Fog L, Sandholm K, Hamad O, Bengtsson A, et al. The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation. J Thromb Haemost. 2016;14:531-45 pubmed publisher
    ESSENTIALS: The lectin pathway's MASP-1/2 activates coagulation factors but the trigger of the activation is unknown. MASP-1/2 activation was assessed by quantifying complexes between MASPs and antithrombin/C1-inhibitor...
  80. von Toerne C, Huth C, de Las Heras Gala T, Kronenberg F, Herder C, Koenig W, et al. MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. Diabetologia. 2016;59:1882-92 pubmed publisher
    ..Mannan-binding lectin serine peptidase 1 (MASP1; OR per SD 1.77 [95% CI 1.26, 2.47]), thrombospondin 1 (THBS1; OR per SD 1.55 [95% CI 1.16, 2...
  81. Chen S, Ma B, Cao M, Yu H, Ma X. [Correlation among serum MBL, MASP-2, HsCRP and C3 levels in rheumatoid arthritis]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1340-1344 pubmed
    ..To investigate the correlation among serum levels of manning-binding lectin (MBL), MBL-associated serine proteases-2 (MASP-2), complement C3 and high-sensitive C reactive protein (HsCRP) in patients with rheumatoid arthritis (..
  82. Takeda S, Kuno R, Barbosa F, Gouveia N. Trace element levels in blood and associated factors in adults living in the metropolitan area of São Paulo, Brazil. J Trace Elem Med Biol. 2017;44:307-314 pubmed publisher
    ..Hg), copper (Cu) and manganese (Mn) levels in a group of residents (n=374) in the metropolitan area of São Paulo (MASP) and investigated the association between trace element levels in blood and sociodemographic and lifestyle factors...
  83. Jenny L, Dobó J, Gál P, Pál G, Lam W, Schroeder V. MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. PLoS ONE. 2018;13:e0191292 pubmed publisher
    ..Complement MASP-1 (mannan-binding lectin-associated serine protease-1) activates coagulation factors and promotes clot formation...
  84. Vorup Jensen T, Petersen S, Hansen A, Poulsen K, Schwaeble W, Sim R, et al. Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol. 2000;165:2093-100 pubmed
    ..shared by MBL and C1 complexes and by the MBL- and C1q-associated serine proteases, MBL-associated serine protease (MASP)-1 and MASP-2, and C1r and C1s, respectively, have led to the expectation that the pathways of complement ..
  85. Petersen S, Thiel S, Jensenius J. The mannan-binding lectin pathway of complement activation: biology and disease association. Mol Immunol. 2001;38:133-49 pubmed
    ..In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms. ..
  86. Matsushita M, Kuraya M, Hamasaki N, Tsujimura M, Shiraki H, Fujita T. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J Immunol. 2002;168:3502-6 pubmed
    ..demonstrated that L-ficolin/P35 is associated with mannose-binding lectin (MBL)-associated serine proteases (MASP) 1 and 2 and small MBL-associated protein (sMAP), and that the complex activates the lectin pathway...
  87. Schmidt M, Chen B, Randazzo L, Bogler O. SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci. 2003;116:2845-55 pubmed
  88. Seyfarth J, Garred P, Madsen H. Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes. Mol Immunol. 2006;43:962-71 pubmed
    ..The mRNA distribution of masp1 and masp2 were found very similar to that of mbl2, while masp3 mRNA seemed ubiquitous present at quite high levels ..
  89. Skjoedt M, Palarasah Y, Munthe Fog L, Jie Ma Y, Weiss G, Skjodt K, et al. MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation. Immunobiology. 2010;215:921-31 pubmed publisher
    ..MASP-3 originates from the MASP1 gene through differential splicing and little is known about its biological characteristics...
  90. Skjoedt M, Roversi P, Hummelshøj T, Palarasah Y, Rosbjerg A, Johnson S, et al. Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1). J Biol Chem. 2012;287:32913-21 pubmed
    ..This protein is the result of a differential splicing of the MASP1 gene and includes the major part of the heavy chain but lacks the serine protease domain...
  91. Sekine H, Takahashi M, Iwaki D, Fujita T. The role of MASP-1/3 in complement activation. Adv Exp Med Biol. 2013;735:41-53 pubmed
    ..pattern recognition molecules for pathogens, resulting in the activation of MBL-associated serine proteases (MASPs: MASP-1, MASP-2, and MASP-3)...
  92. Degn S, Jensen L, Olszowski T, Jensenius J, Thiel S. Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol. 2013;191:1334-45 pubmed publisher
    ..in complexes with MBL-associated serine proteases (MASP-1, -2, and -3) and MBL-associated proteins (MAp19 and MAp44)...