MARCKS

Summary

Gene Symbol: MARCKS
Description: myristoylated alanine rich protein kinase C substrate
Alias: 80K-L, MACS, PKCSL, PRKCSL, myristoylated alanine-rich C-kinase substrate, myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L), phosphomyristin, protein kinase C substrate, 80 kDa protein, light chain
Species: human
Products:     MARCKS

Top Publications

  1. Hartwig J, Thelen M, Rosen A, Janmey P, Nairn A, Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature. 1992;356:618-22 pubmed
    ..The myristoylated, alanine-rich C kinase substrate (MARCKS) binds calmodulin and is a predominant, specific substrate of PKC which is phosphorylated during macrophage and ..
  2. Li Y, Martin L, Spizz G, Adler K. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem. 2001;276:40982-90 pubmed
    ..Direct evidence is provided that the myristoylated alanine-rich C kinase substrate (MARCKS) is a central regulatory molecule linking secretagogue stimulation at the cell surface to mucin granule release by ..
  3. Li T, Li D, Sha J, Sun P, Huang Y. MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochem Biophys Res Commun. 2009;383:280-5 pubmed publisher
    ..We identified myristoylated alanine-rich protein kinase c substrate (MARCKS), which plays key roles in cell motility, as a new target in prostate cancer cells...
  4. Balasubramaniam S, Riley L, Bratkovic D, Ketteridge D, Manton N, Cowley M, et al. Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency. J Inherit Metab Dis. 2017;40:745-747 pubmed publisher
    ..1 deficiency; pyrroline-5-carboxylate synthase deficiency; macrocephaly, alopecia, cutis laxa, and scoliosis (MACS) syndrome, due to Ras and Rab interactor 2 (RIN2) mutations; transaldolase deficiency caused by mutations in the ..
  5. Leng Z, Gao Z, He X, Zhao Y, Sun L, Zhai J, et al. [Cultivation, screening, identification and transplantation of Muse cell from human umbilical cord-derived for spinal cord injury in rats]. Zhongguo Gu Shang. 2019;32:327-334 pubmed publisher
    ..5%, positive rate of SSEA3+ was 1.46% under flow cytometer, However, after MACS sorting, the percentage of 92...
  6. Zhu J, Bi Z, Yang T, Wang W, Li Z, Huang W, et al. Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells. PLoS ONE. 2014;9:e113733 pubmed publisher
    ..benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS)...
  7. Westphal N, Loers G, Lutz D, Theis T, Kleene R, Schachner M. Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus. Sci Rep. 2017;7:8622 pubmed publisher
    ..NCAM antibody and a peptide comprising the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) which interacts with PSA within the plane of the plasma membrane...
  8. Ruenraroengsak P, Tetley T. Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells. Part Fibre Toxicol. 2015;12:19 pubmed publisher
    ..UNP and CNP exhibited little cytotoxicity or mitochondrial damage, although they induced ROS in AT2 and MACs. Addition of NAC reduced epithelial cell ROS, but not MAC ROS, for up to 4 h...
  9. Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
    ..To selectively characterize microglial and non-microglial brain cells, an acutely isolated microglia fraction using MACS microbeads (Miltenyi Biotec) conjugated with CD11b antibody and a microglia-depleted fraction were analyzed for ..

More Information

Publications142 found, 100 shown here

  1. Ramm R, Hartmann T, Tudorache I, Haverich A, Hilfiker A. No evidence for αGal epitope transfer from media containing FCS onto human endothelial cells in culture. Xenotransplantation. 2015;22:345-55 pubmed publisher
    ..and atrial appendage tissue samples by enzymatic digestion followed by magnetic-activated cell separation (MACS) utilizing CD31 antibodies. The cells were cultured in EGM-2 medium containing 10% FCS for several passages...
  2. Liang P, Peng S, Zhang M, Ma Y, Zhen X, Li H. Huai Qi Huang corrects the balance of Th1/Th2 and Treg/Th17 in an ovalbumin-induced asthma mouse model. Biosci Rep. 2017;37: pubmed publisher
    ..cells into the lung, reduced influx of eosinophils (EOSs), lymphocytes (LYMs), neutrophils (NEUs), and macrophages (MACs) in the BALF, and decreased IgE in the serum in OVA-treated mice...
  3. Atashi A, Islami M, Mortazavi Y, Soleimani M. Homing Genes Expression in Fucosyltransferase VI-Treated Umbilical Cord Blood CD133+ Cells which Expanded on Protein-Coated Nanoscaffolds. Mol Biotechnol. 2018;60:455-467 pubmed publisher
    ..The purity of MACS isolated CD133+ cells and confirmation of fucosylation were done by flow cytometry, and the viability of cells ..
  4. Qin T, Li B, Feng X, Fan S, Liu L, Liu D, et al. Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. J Exp Clin Cancer Res. 2018;37:287 pubmed publisher
    ..Sorting of breast cancer stem cells (BCSCs) were by using MACS assay...
  5. Nafarieh T, Bandehpour M, Hashemi A, Taheri S, Yardel V, Jamaati H, et al. Identification of antigens from nosocomial Acinetobacter baumannii clinical isolates in sera from ICU staff and infected patients using the antigenome technique. World J Microbiol Biotechnol. 2017;33:189 pubmed publisher
    ..serum samples by affinity chromatography was used to isolate the bacteria by the Magnetic-activated cell sorting (MACS) procedure...
  6. Wei W, Xu C, Ye Z, Huang X, Yuan J, Ma T, et al. [Biological characteristics of mesenchymal stem cell and hematopoietic stem cell in the co-culture system]. Sheng Li Xue Bao. 2016;68:691-698 pubmed
    ..from umbilical cord blood by Ficoll lymphocyte separation medium, and then CD34+ HSC was collected by MACS immunomagnetic beads. The selected CD34+ HSC/HPC and MSC were transferred into culture flask...
  7. Xiao M, Feng Y, Cao G, Liu C, Zhang Z. A novel MtHSP70-FPR1 fusion protein enhances cytotoxic T lymphocyte responses to cervical cancer cells by activating human monocyte-derived dendritic cells via the p38 MAPK signaling pathway. Biochem Biophys Res Commun. 2018;503:2108-2116 pubmed publisher
    ..Monocytes were positively selected with a MACS column with antiCD14 antibody-conjugated microbeads from umbilical cord blood...
  8. Bianchetti L, Tarabay Y, Lecompte O, Stote R, Poch O, Dejaegere A, et al. Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes. BMC Evol Biol. 2015;15:222 pubmed publisher
    ..Using multiple alignments of complete protein sequences (MACS), we inferred Tex19 and Sectm1 molecular phylogenies...
  9. Sanges S, Jendoubi M, Kavian N, Hauspie C, Speca S, Crave J, et al. B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis. Front Immunol. 2017;8:53 pubmed publisher
    ..For functional studies, splenic B cells were immediately MACS-sorted...
  10. Obis T, Besalduch N, Hurtado E, Nadal L, Santafe M, Garcia N, et al. The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Mol Brain. 2015;8:8 pubmed publisher
    ..Moreover, nPKCε activity results in phosphorylation of the substrate MARCKS involved in actin cytoskeleton remodeling and related with neurotransmission...
  11. McLeish K, Merchant M, Creed T, Tandon S, Barati M, Uriarte S, et al. Frontline Science: Tumor necrosis factor-? stimulation and priming of human neutrophil granule exocytosis. J Leukoc Biol. 2017;102:19-29 pubmed publisher
    ..quantity, formation, or release, 4 of which-Raf1, myristoylated alanine-rich protein kinase C (PKC) substrate (MARCKS), Abelson murine leukemia interactor 1 (ABI1), and myosin VI-were targets of the p38 MAPK pathway...
  12. Uno N, Fujimoto T, Komoto S, Kurosawa G, Sawa M, Suzuki T, et al. A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors. Cytotechnology. 2018;70:1499-1508 pubmed publisher
    ..Here, we developed LCAs with mouse artificial chromosomes (MACs) that have unique characteristics such as stable maintenance and a substantial insert-carrying capacity...
  13. Bahreini A, Levine K, Santana Santos L, Benos P, Wang P, Andersen C, et al. Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Med. 2016;8:128 pubmed
    ..GATK pipeline was used to identify SNVs and the MACS algorithm was employed to call DNA-binding sites...
  14. Muthusamy N, Sommerville L, Moeser A, Stumpo D, SANNES P, ADLER K, et al. MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging. Aging Cell. 2015;14:764-73 pubmed publisher
    ..of these functions in part requires the expression of the myristoylated alanine-rich protein kinase C substrate (MARCKS). Both the expression levels and subcellular localization of MARCKS in ECs are markedly transformed during aging...
  15. Hagedorn M, Siegfried G, Hooks K, Khatib A. Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers. Oncotarget. 2016;7:71567-71579 pubmed publisher
    ..the role of TNC (tenascin C) and FN1 (fibronectin 1) in melanoma development is well documented, implication of MARCKS, RCN3, BAMBI, PEA3/ETV4 and the FK506 family members FKBP7, FKBP10 and FKBP11 in melanoma progression is unclear...
  16. Rabelo K, Trugilho M, Costa S, Pereira B, Moreira O, Ferreira A, et al. The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach. J Proteomics. 2017;152:339-354 pubmed publisher
    ..Down regulation expression of one protein (MARCKS), identified by the proteomic analysis, was also confirmed by real time PCR in HepG2 cells infected with DENV2...
  17. Zettergren A, Karlsson S, Studer E, Sarvimäki A, Kettunen P, Thorsell A, et al. Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice. BMC Neurosci. 2017;18:9 pubmed publisher
    ..3). The protein MARCKS (myristoylated alanine rich C kinase substrate), having the largest fold change of the proteins selected from the iTRAQ analyses and of known ..
  18. Maschmann J, Goelz R, Witzel S, Strittmatter U, Steinmassl M, Jahn G, et al. Characterization of human breast milk leukocytes and their potential role in cytomegalovirus transmission to newborns. Neonatology. 2015;107:213-9 pubmed publisher
    ..To characterize CMV target cells in breast milk, we enriched CD14+ cells by MACS (Miltenyi) and monitored cell fractions using CMV IEEx4 nested PCR and pp67 CMV RNA by NASBA...
  19. Fricke S, Rothe K, Hilger N, Ackermann M, Oelkrug C, Fricke C, et al. Allogeneic bone marrow grafts with high levels of CD4(+) CD25(+) FoxP3(+) T cells can lead to engraftment failure. Cytometry A. 2012;81:476-88 pubmed publisher
    ..T(regs) from splenocytes of C57Bl/6 and Balb/c wild-type mice were isolated by MACS separation and analyzed by flow cytometry...
  20. Dong Y, Lian X, Xu Y, Hu H, Chang C, Zhang H, et al. Hematopoietic stem/progenitor cell senescence is associated with altered expression profiles of cellular memory-involved gene. Biosci Rep. 2018;38: pubmed publisher
    ..as HSPC) were separated from young (6-week-old) and aged (18-month-old) mice using Magnetic Activated Cell Sorting (MACS). Cell cycle distribution of HSPCs was determined using flow cytometry...
  21. Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS ONE. 2015;10:e0116644 pubmed publisher
    ..Samples were generated from CD11b+ MACS-isolated cells from naïve and GL261-implanted C57BL/6 mouse brains...
  22. Martens G, De Punt V, Stangé G. CD99 as surface anchor for human islet endocrine cell purification. J Tissue Eng Regen Med. 2018;12:e171-e176 pubmed publisher
    ..A MACS-CD99 purification of human pancreas fractions with low endocrine purity consistently yielded a fourfold enrichment ..
  23. Szabo S, Machado Vieira R, Yuan P, Wang Y, Wei Y, Falke C, et al. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology. 2009;56:47-55 pubmed publisher
    ..Phosphorylation of MARCKS, a marker of PKC activity, was increased in the prefrontal cortex of animals treated with the psychostimulant ..
  24. Li R, Hempel L, Jiang T. A non-parametric peak calling algorithm for DamID-Seq. PLoS ONE. 2015;10:e0117415 pubmed publisher
    ..distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling...
  25. He X, Ding Y, Xiang W, Dang X. Roles of 1,25(OH)2D3 and Vitamin D Receptor in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Regulating the Activation of CD4+ T Cells and the PKCδ/ERK Signaling Pathway. Cell Physiol Biochem. 2016;40:743-756 pubmed
    ..CD4+ T cells were separated using magnetic activated cell sorting (MACS)...
  26. Guo X, Wang S, Dou Y, Guo X, Chen Z, Wang X, et al. A Convenient and Efficient Method to Enrich and Maintain Highly Proliferative Human Fetal Liver Stem Cells. Rejuvenation Res. 2015;18:211-24 pubmed publisher
    ..we have demonstrated a more economical and efficient method to isolate hFLSCs than magnetic-activated cell sorting (MACS)...
  27. Ko H, Guo L, Su B, Gao L, Gelman I. Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge. PLoS ONE. 2014;9:e111534 pubmed publisher
    ..full-length SSeCKS or SSeCKS deleted of its Src-binding domain (ΔSrc), but not by SSeCKS deleted of its three MARCKS (myristylated alanine-rich C kinase substrate) polybasic domains (ΔPBD), which bind PIP2 and PIP3...
  28. Singh J, Shah R, Singh D. Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases. Int Immunopharmacol. 2016;40:362-384 pubmed publisher
    ..involving cascade of events like membrane fusion events and various proteins like VAMP, Syntaxins, DOCK5, SNAP-23, MARCKS. Furthermore, we described these mast cell receptors antagonists or agonists useful in treatment of myriad ..
  29. Lampe W, Park J, Fang S, Crews A, Adler K. Calpain and MARCKS protein regulation of airway mucin secretion. Pulm Pharmacol Ther. 2012;25:427-31 pubmed publisher
    ..Myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been shown to play an important role in regulation of airway mucin secretion, as peptides analogous ..
  30. Sonnenburg E, Smits S, Tikhonov M, Higginbottom S, Wingreen N, Sonnenburg J. Diet-induced extinctions in the gut microbiota compound over generations. Nature. 2016;529:212-5 pubmed publisher
    ..Microbiota-accessible carbohydrates (MACs) found in dietary fibre have a crucial involvement in shaping this microbial ecosystem, and are notably reduced in ..
  31. Sosa L, Malter J, Hu J, Bustos Plonka F, Oksdath M, Nieto Guil A, et al. Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization. J Neurochem. 2016;137:744-55 pubmed publisher
    ..Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the ..
  32. Du C, Shen N, Li J, Hao M, Wang Z, Cheng C, et al. Two novel selenidostannates from mixed structure-directing systems: the large ten-membered ring of [Sn3Se4] semicubes and the 3D [Sn4Se9]n(2n-) with multi-channels. Dalton Trans. 2016;45:9523-8 pubmed publisher
    ..ionic liquid (IL) [Bmmim]Cl (Bmmim = 1-butyl-2,3-dimethylimidazolium) and in-situ generated metal-amine complexes (MACs), namely, 2D-(Bmmim)2[Ni(teta)(en)][Sn3Se7]2 (1, teta = triethylenetetramine, en = ethylenediamine) and 3D-(Bmmim)1...
  33. de Bruin R, Lougheed S, van der Kruk L, Stam A, Hooijberg E, Roovers R, et al. Highly specific and potently activating V?9V?2-T cell specific nanobodies for diagnostic and therapeutic applications. Clin Immunol. 2016;169:128-138 pubmed publisher
    ..With high specificity and affinity, the anti-V?9V?2-T cell receptor VHHs are shown to be useful for FACS, MACS and immunocytochemistry. In addition, some VHH were found to specifically activate V?9V?2-T cells...
  34. Meng M, Li C, Yang F, Chen H, Li X, Yang Y, et al. Novel immunostimulators with a thiazolidin-4-one ring promote the immunostimulatory effect of human iNKT cells on the stimulation of Th2-like immune responsiveness via GATA3 activation in vitro. Int Immunopharmacol. 2016;39:353-358 pubmed publisher
    ..Then, the highly purified iNKTs were isolated from PBMCs using magnetic cells sorting (MACS)...
  35. Ding J, Zhao J, Zhou J, Li X, Wu Y, Ge M, et al. Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis. PLoS ONE. 2018;13:e0191930 pubmed publisher
    ..79-1.13), Furthermore, we failed to find an delayed AIDS progression except in some specific cohorts including MACS cohorts (RH = 0.38, 95% Cl: 0.17-0.59 for time to AIDS; RH = 0.27, 95% Cl: 0.07-0...
  36. Ravelo K, Andersen N, Monje P. Magnetic-Activated Cell Sorting for the Fast and Efficient Separation of Human and Rodent Schwann Cells from Mixed Cell Populations. Methods Mol Biol. 2018;1739:87-109 pubmed publisher
    To date, magnetic-activated cell sorting (MACS) remains a powerful method to isolate distinct cell populations based on differential cell surface labeling...
  37. Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed publisher
    Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia...
  38. Moghaddam F, Oodi A, Nikougoftar Zarif M, Amani M, Amirizadeh N. Expression of CXCR4 in cord blood-derived CD133+ cells treated with platelet micro-particles. Artif Cells Nanomed Biotechnol. 2016;44:1702-7 pubmed publisher
    ..Cord blood CD133+ cells were isolated by MACS. Isolated cells were divided into three groups: (i) control cells, (ii) cells treated with 5 μg/ml PMPs, (..
  39. Xu M, Chen Z, Zhou Z, Zheng Y, Yuan Y, Zhang Q, et al. [Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates]. Zhonghua Yi Xue Za Zhi. 2015;95:2532-6 pubmed
    ..The qRT-PCR analysis of 2 up-regulated genes (CXCL14, KCNMA1) and 4 under-regulated genes (MARCKS, ZEB2, PSMF1, and CNN2) mRNA expression levels validated the results from the microarray analysis...
  40. Lee H, Jae J, Ha J, Suh D. Hydro- and solvothermolysis of kraft lignin for maximizing production of monomeric aromatic chemicals. Bioresour Technol. 2016;203:142-9 pubmed publisher
    ..The effect of the water-to-ethanol ratio on the yields of monomeric aromatic chemicals (MACs) and the kinetic behavior of MACs was studied in a series of batch experiments...
  41. Ziemba B, Burke J, Masson G, Williams R, Falke J. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J. 2016;110:1811-1825 pubmed publisher
    ..kinase C (Ca(2+)-PKC) is hypothesized to phosphorylate myristoylated alanine-rich C kinase substrate (MARCKS) and release phosphatidylinositol-4,5-bisphosphate (PIP2), thereby stimulating production of the signaling lipid ..
  42. Dessauer C, Watts V, Ostrom R, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev. 2017;69:93-139 pubmed publisher
    ..This review will largely focus on mACs. mACs are activated by the G-protein G?s and regulated by multiple mechanisms...
  43. Montgomery D, Yu L, Ghazi Z, Thai T, Al Khalili O, Ma H, et al. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins. Am J Physiol Cell Physiol. 2017;313:C42-C53 pubmed publisher
    We previously demonstrated a role for the myristoylated alanine-rich C kinase substrate (MARCKS) to serve as an adaptor protein in the anionic phospholipid phosphate-dependent regulation of the epithelial sodium channel (ENaC)...
  44. Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher
    ..barrier disruption, we performed proximity-dependent biotinylation (BioID) of occludin and found that tagging of MARCKS-related protein (MRP; also known as MARCKSL1) increased ∼20-fold following IFN/TNF administration...
  45. Huang S, Wang W, Chi L. Feasibility of up-regulating CD4(+)CD25(+) Tregs by IFN-γ in myasthenia gravis patients. BMC Neurol. 2015;15:163 pubmed publisher
    ..cells of MG patients and HCs, and the CD4(+)CD25(+) Tregs were separated from HCs by Magnetic cell sorting (MACS). IFN-γ with different concentrations was used to stimulate CD4(+)CD25(-) T cells...
  46. Engmann O, Giralt A, Gervasi N, Marion Poll L, Gasmi L, Filhol O, et al. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun. 2015;6:10099 pubmed publisher
    ..DARPP-32 binds to adducin MARCKS domain and this interaction is modulated by DARPP-32 Ser97 phosphorylation...
  47. Hamuro J, Ueno M, Toda M, Sotozono C, Montoya M, Kinoshita S. Cultured Human Corneal Endothelial Cell Aneuploidy Dependence on the Presence of Heterogeneous Subpopulations With Distinct Differentiation Phenotypes. Invest Ophthalmol Vis Sci. 2016;57:4385-92 pubmed publisher
    ..whole-cell preparations (bulk) consisting of mixed SPs or as a semipurified SP by magnetic activated cell sorting (MACS). The HCEC donors ranged from 9 to 69 years of age and the culture passages from primary to fifth passage...
  48. Romany L, Garrido N, Cobo A, Aparicio Ruiz B, Serra V, Meseguer M. Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial. J Assist Reprod Genet. 2017;34:201-207 pubmed publisher
    The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial...
  49. Yevshin I, Sharipov R, Valeev T, Kel A, Kolpakov F. GTRD: a database of transcription factor binding sites identified by ChIP-seq experiments. Nucleic Acids Res. 2017;45:D61-D67 pubmed publisher
    ..and uniformly processed: (i) reads were aligned using Bowtie2; (ii) ChIP-seq peaks were called using peak callers MACS, SISSRs, GEM and PICS; (iii) peaks for the same factor and peak callers, but different experiment conditions (cell ..
  50. Liu M, Wang P, Zhao M, Liu D. Intestinal Dendritic Cells Are Altered in Number, Maturity and Chemotactic Ability in Fulminant Hepatic Failure. PLoS ONE. 2016;11:e0166165 pubmed publisher
    ..Mouse intestinal and spleen DCs were isolated by magnetic-activated cell sorting (MACS) and surface markers of DCs, namely CD11c, CD74, CD83 and CD86, were identified using flow cytometry...
  51. Kronenberg G, Uhlemann R, Schöner J, Wegner S, Boujon V, Deigendesch N, et al. Repression of telomere-associated genes by microglia activation in neuropsychiatric disease. Eur Arch Psychiatry Clin Neurosci. 2017;267:473-477 pubmed publisher
    ..biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, Alzheimer's disease, and chronic stress...
  52. Skorska A, Müller P, Gaebel R, Große J, Lemcke H, Lux C, et al. GMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration. Stem Cell Res Ther. 2017;8:33 pubmed publisher
    ..in centralized clean room facilities using semi-automatic manufacturing processes based on magnetic cell sorting (MACS®). However, this requires time-consuming and cost-intensive logistics...
  53. Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, et al. Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice. Stem Cell Reports. 2017;9:1180-1191 pubmed publisher
    ..Successful transfer of MACs to GSCs overcomes the problems associated with ESC-mediated germline transmission and provides new possibilities in ..
  54. Vogelbacher C, Möbius T, Sommer J, Schuster V, Dannlowski U, Kircher T, et al. The Marburg-Münster Affective Disorders Cohort Study (MACS): A quality assurance protocol for MR neuroimaging data. Neuroimage. 2018;172:450-460 pubmed publisher
    ..The protocol is implemented in the MACS (Marburg-Münster Affective Disorders Cohort Study, http://for2107...
  55. Zhang Y, Liu Z, Wu J, Bai B, Chen H, Xiao Z, et al. New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity. Eur J Med Chem. 2018;148:291-305 pubmed publisher
    ..We developed new curcumin analogs (MACs) with removal of the β-diketone moiety and substituted residues in benzene rings, and identify these as ..
  56. Taruno A. ATP Release Channels. Int J Mol Sci. 2018;19: pubmed publisher
    ..VRACs, also known as volume-sensitive outwardly rectifying (VSOR) anion channels), and maxi-anion channels (MACs)...
  57. Weng Q, Fu L, Chen G, Hui J, Song J, Feng J, et al. Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin. Eur J Med Chem. 2015;103:44-55 pubmed publisher
    ..reported the design and discovery of series of 5-carbon linker-containing mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents...
  58. Müller P, Gaebel R, Lemcke H, Wiekhorst F, Hausburg F, Lang C, et al. Intramyocardial fate and effect of iron nanoparticles co-injected with MACS® purified stem cell products. Biomaterials. 2017;135:74-84 pubmed publisher
    Magnetic activated cell sorting (MACS®) is routinely used to isolate stem cell subpopulations intended for the treatment of cardiovascular diseases...
  59. Taniguchi H, Manenti S, Suzuki M, Titani K. Myristoylated alanine-rich C kinase substrate (MARCKS), a major protein kinase C substrate, is an in vivo substrate of proline-directed protein kinase(s). A mass spectroscopic analysis of the post-translational modifications. J Biol Chem. 1994;269:18299-302 pubmed
    Myristoylated alanine-rich C kinase substrate (MARCKS), a major in vivo substrate protein of protein kinase C, isolated from calf brain contains various species phosphorylated to different degrees...
  60. Akhtar Khaleel W, Cook R, Shoptaw S, Surkan P, Stall R, Beyth R, et al. Trends and Predictors of Cigarette Smoking Among HIV Seropositive and Seronegative Men: The Multicenter Aids Cohort Study. AIDS Behav. 2016;20:622-32 pubmed publisher
    ..thousand and five hundred and seventy seven men who have sex with men (MSM) from the Multicenter AIDS Cohort Study (MACS) were asked detailed information about their smoking history since their visit...
  61. Aziz N, Detels R, Chang L, Butch A. Macrophage Inflammatory Protein-3 Alpha (MIP-3α)/CCL20 in HIV-1-Infected Individuals. J AIDS Clin Res. 2016;7: pubmed
    ..and IFN-γ, in 167 HIV-1-infected and 27 HIV-1-uninfected men participating in the Multicenter AIDS Cohort Study (MACS)...
  62. Mei J, Li H, Cao H, Shao J, Zhai Y. [Application Value of CD138 MACS-FISH in the Genetic Diagnosis of Plasma Cell Dyscrasia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1437-1442 pubmed publisher
    To investigate the cytogenetic characteristics of the various plasma cell dyscrasia using the CD138 MACS-FISH, to elucidate the application value of MACS-FISH in the genetic diagnosis of plasma cell dyscrasia, and to explore the ..
  63. Jia Z, Liang Y, Xu X, Li X, Liu Q, Ou Y, et al. Isolation and characterisation of human mesenchymal stem cells derived from synovial fluid by magnetic activated cell sorting (MACS). Cell Biol Int. 2017;: pubmed publisher
    ..We have successfully purified hSF-MSCs using magnetic activated cell sorting (MACS) sorting using the MSC surface marker, CD90...
  64. Yu D, Makkar G, Dong T, Strickland D, Sarkar R, Monahan T. MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism. PLoS ONE. 2015;10:e0141397 pubmed publisher
    Overexpression of the myristolated alanine-rich C kinase substrate (MARCKS) occurs in vascular proliferative diseases such as restenosis after bypass surgery...
  65. Aghili B, Amirzargar A, Rajab A, Rabbani A, Sotoudeh A, Assadiasl S, et al. Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes. Iran J Immunol. 2015;12:240-51 pubmed publisher
    ..Thereafter, Tregs were isolated by Magnetic-Activated Cell Separation (MACS) technology and by using CFSE (carboxyfluorescein succinimidyl ester) dilution assay, their suppressive activity ..
  66. Santos Ferreira T, Völkner M, Borsch O, Haas J, Cimalla P, Vasudevan P, et al. Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. Invest Ophthalmol Vis Sci. 2016;57:3509-20 pubmed publisher
    ..Organoid-derived photoreceptors were enriched by CD73-based magnetic-activated cell sorting (MACS) and transplanted subretinally into wild-type, Prom1-/- and Cpfl1/Rho-/- hosts...
  67. Velaga S, Alter C, Dringenberg U, Thiesler C, Kuhs S, Olek S, et al. Clinical-grade regulatory T cells: Comparative analysis of large-scale expansion conditions. Exp Hematol. 2017;45:27-35.e1 pubmed publisher
    ..Donor Tregs were isolated using magnetic-activated cell sorting (MACS) technology with good manufacturing practice-compliant devices...
  68. Manenti S, Yamauchi E, Sorokine O, Knibiehler M, Van Dorsselaer A, Taniguchi H, et al. Phosphorylation of the myristoylated protein kinase C substrate MARCKS by the cyclin E-cyclin-dependent kinase 2 complex in vitro. Biochem J. 1999;340 ( Pt 3):775-82 pubmed
    The myristoylated alanine-rich C-kinase substrate (MARCKS) purified from brain was recently characterized as a proline-directed kinase(s) substrate in vivo [Taniguchi, Manenti, Suzuki and Titani (1994) J. Biol. Chem. 269, 18299-18302]...
  69. You K, Li L, Kim N, Kang H, Koh K, Chwae Y, et al. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 2007;5:e109 pubmed
    ..We demonstrated that transfection of NMD-irrelevant PTC-containing genomic DNA of MARCKS generates truncated protein...
  70. Kuo H, Gordon A, Henrionnet A, Hautfenne S, Friel K, Bleyenheuft Y. The effects of intensive bimanual training with and without tactile training on tactile function in children with unilateral spastic cerebral palsy: A pilot study. Res Dev Disabil. 2016;49-50:129-39 pubmed publisher
    ..Twenty children with USCP (6-15.5 years; MACS: I-III) were randomized to receive either bimanual therapy (HABIT) or HABIT+tactile training (HABIT+T)...
  71. Cormier N, Kolisnik T, Bieda M. Reusable, extensible, and modifiable R scripts and Kepler workflows for comprehensive single set ChIP-seq analysis. BMC Bioinformatics. 2016;17:270 pubmed publisher
    ..Implementation emphasized use of common R packages and widely-used external tools (e.g., MACS for peak finding), along with custom programming...
  72. Jalayeri M, Pirnia A, Najafabad E, Varzi A, Gholami M. Evaluation of alginate hydrogel cytotoxicity on three-dimensional culture of type A spermatogonial stem cells. Int J Biol Macromol. 2017;95:888-894 pubmed publisher
    ..stem cells of 6day-old immature mice were isolated by surgery; thereafter, the cells were purified by MACS using antibodies against thy-1 and C-kit and cultured on a layer of laminin...
  73. Tibuakuu M, Zhao D, Saxena A, Brown T, Jacobson L, Palella F, et al. Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr. 2018;12:131-138 pubmed publisher
    ..We performed cross-sectional analysis of 513 male MACS participants (72% HIV-infected) who underwent mid-thigh computed tomography (CT) and non-contrast cardiac CT for ..
  74. Chen Z, Liu Y, Yao L, Guo S, Gao Y, Zhu P. The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. J Biol Chem. 2018;293:7982-7992 pubmed publisher
    ..lncZic2 drove the expression of myristoylated alanine-rich protein kinase C substrate (MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels were increased during liver tumorigenesis and liver TIC ..
  75. Herget T, Brooks S, Broad S, Rozengurt E. Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. Eur J Biochem. 1992;209:7-14 pubmed
    ..PKC) substrates have been described in the literature; an 87-kDa bovine and human PKC substrate, called MARCKS, and an acidic 80-kDa PKC substrate, isolated from rat brain and Swiss 3T3 cells, termed 80K...
  76. Yang Y, Chen Y, Saha M, Chen J, Evans K, Qiu L, et al. Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma. Leukemia. 2015;29:715-26 pubmed publisher
    ..We identified selective overexpression of myristoylated alanine-rich C-kinase substrate (MARCKS) in drug-resistant R5 cells...
  77. Ziemba B, Swisher G, Masson G, Burke J, Williams R, Falke J. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 2016;55:6395-6405 pubmed
    ..protein kinase C (PKC) and the phosphatidylinositol 4,5-bisphosphate (PIP2) binding protein MARCKS as two important players in this signaling, because PKC phosphorylation of MARCKS releases free PIP2 ..
  78. Manai M, Thomassin Piana J, Gamoudi A, Finetti P, Lopez M, Eghozzi R, et al. MARCKS protein overexpression in inflammatory breast cancer. Oncotarget. 2017;8:6246-6257 pubmed publisher
    ..Identification of new therapeutic targets is crucial. We previously reported MARCKS mRNA overexpression in IBC in the largest transcriptomics study reported to date...
  79. Park S, Webster C, ANWER M. Mechanism of inhibition of taurolithocholate-induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate. Physiol Rep. 2017;5: pubmed publisher
    ..decreases PM-MRP2 by activating PKC? followed by phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS)...
  80. Dulong S, Goudenege S, Vuillier Devillers K, Manenti S, Poussard S, Cottin P. Myristoylated alanine-rich C kinase substrate (MARCKS) is involved in myoblast fusion through its regulation by protein kinase Calpha and calpain proteolytic cleavage. Biochem J. 2004;382:1015-23 pubmed
    b>MARCKS (myristoylated alanine-rich C kinase substrate) is a major cytoskeletal protein substrate of PKC (protein kinase C) whose cellular functions are still unclear...
  81. Micallef J, Taccone M, Mukherjee J, Croul S, Busby J, Moran M, et al. Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res. 2009;69:7548-56 pubmed publisher
    ..Here, we show myristoylated alanine-rich protein kinase C substrate (MARCKS), previously implicated in cell adhesion and motility, contributes to EGFR-mediated invasion of human GBM cells...
  82. Zhang H, Liu W, Feng X, Wang L, Jiang X, Liu D, et al. Identification of ABCG2⁺ cells in nasopharyngeal carcinoma cells. Oncol Rep. 2012;27:1177-87 pubmed publisher
    ..By using magnetic cell sorting (MACS) method, we isolated ABCG2⁺ cells and ABCG2⁻ cells from 5-8F cells...
  83. Konopaske G, Subburaju S, Coyle J, Benes F. Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder. Schizophr Res. 2015;164:100-8 pubmed publisher
    ..The relative mRNA expression of the genes linked to dendritic spine growth and function, i.e. IGF1R, MARCKS, PPP1R9A, PTPRF, and ARHGEF2, was assessed using quantitative real-time PCR (qRT-PCR) in the DLPFC from a second ..
  84. Rohrbach T, Shah N, Jackson W, Feeney E, Scanlon S, Gish R, et al. The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. PLoS ONE. 2015;10:e0140870 pubmed publisher
    ..is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus...
  85. Lelubre C, Medfai H, Akl I, Leentjens J, Kox M, Pickkers P, et al. Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression. J Leukoc Biol. 2017;101:1419-1426 pubmed publisher
    ..PDE4B protein expression was also studied in magnetic-activated cell sorting (MACS)-isolated CD15+ neutrophils (from 7 healthy volunteers, 5 patients without and 5 with sepsis)...
  86. Zhang Z, Ma F, Zhang H, Xu X. MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation. Neurochem Res. 2017;42:2933-2939 pubmed publisher
    ..Since myristoylated alanine-rich C-kinase substrate (MARCKS) reportedly contributes to Ras-associated protein (Rab)-10-associated vesicle insertion into neuronal membranes, ..
  87. Moghaddam S, Yousefi B, Sanooghi D, Faghihi F, Hayati Roodbari N, Bana N, et al. Differentiation potential of human CD133 positive hematopoietic stem cells into motor neuron- like cells, in vitro. J Chem Neuroanat. 2017;86:35-40 pubmed publisher
    ..CD133+ HSCs were isolated from human UCB using MACS system...
  88. Alghamdi M, Chiarello L, Palisano R, McCoy S. Understanding participation of children with cerebral palsy in family and recreational activities. Res Dev Disabil. 2017;69:96-104 pubmed publisher
    ..level of function using Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), and Communication Function Classification System (CFCS)...
  89. Lee W, Kim M, Park I, Hwang J, Na M, Bae J. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity. Food Chem Toxicol. 2017;109:19-27 pubmed publisher
    ..They inhibited ADP- and U46619-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) and the expression of P-selectin and PAC-1 in platelets...
  90. Goudot C, Coillard A, Villani A, Guéguen P, Cros A, Sarkizova S, et al. Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. Immunity. 2017;47:582-596.e6 pubmed publisher
    ..How monocyte fate is directed toward monocyte-derived macrophages (mo-Macs) or monocyte-derived DCs (mo-DCs) and which transcription factors control these differentiation pathways remains ..
  91. Zhang H, Huang Y, Wang W, Chen H, Langland Orban B. Bayesian quantile regression-based partially linear mixed-effects joint models for longitudinal data with multiple features. Stat Methods Med Res. 2017;:962280217730852 pubmed publisher
    ..The proposed models are applied to analyze the Multicenter AIDS Cohort Study (MACS) data...
  92. Lu Y, Meng F, Yang Y, Li L, Wang D, Cui Y, et al. Significance of B10 cell in patients with thymoma complicated with myasthenia gravis. Oncotarget. 2017;8:73774-73786 pubmed publisher
    ..the serum concentration of the relevant immunological markers; purified CD19+B cells in tissues by MACS; gene and protein expressions of CD19 and IL-10 by Real-time PCR and Western-Blot; double immunofluorescence ..