MAPK8IP2

Summary

Gene Symbol: MAPK8IP2
Description: mitogen-activated protein kinase 8 interacting protein 2
Alias: IB-2, IB2, JIP2, PRKM8IPL, C-Jun-amino-terminal kinase-interacting protein 2, JNK MAP kinase scaffold protein 2, JNK MAP kinase scaffold protein JIP2, JNK-interacting protein 2, homologous to mouse JIP-1, islet-brain 2
Species: human
Products:     MAPK8IP2

Top Publications

  1. Kelkar N, Gupta S, Dickens M, Davis R. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol. 2000;20:1030-43 pubmed
    ..JIP3 is a member of a novel class of putative MAPK scaffold proteins that may regulate signal transduction by the JNK pathway. ..
  2. Willoughby E, Perkins G, Collins M, Whitmarsh A. The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. J Biol Chem. 2003;278:10731-6 pubmed
    ..These results indicate that the JIP-1 scaffold protein modulates JNK signaling via association with both protein kinases and protein phosphatases that target JNK. ..
  3. Yasuda J, Whitmarsh A, Cavanagh J, Sharma M, Davis R. The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999;19:7245-54 pubmed
    ..The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell ..
  4. Kristensen O, Guenat S, Dar I, Allaman Pillet N, Abderrahmani A, Ferdaoussi M, et al. A unique set of SH3-SH3 interactions controls IB1 homodimerization. EMBO J. 2006;25:785-97 pubmed
    ..Taken together, these results indicate that IB1 homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process. ..
  5. Matsuda S, Matsuda Y, D ADAMIO L. Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem. 2003;278:38601-6 pubmed
    ..Our data suggest that kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing, may be regulated by JIP1. ..
  6. Barnea E, Kirk D, Paidas M. Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua. Reprod Biol Endocrinol. 2012;10:50 pubmed publisher
    ..01, P < 0.04, respectively). Stress-induced p-38-MAPK (P = 0.04) and c-Jun kinase signaling involved MAPK8IP2 (-2.1 fold) expression decreased which protects against reactive oxygen species...
  7. Kanao H, Aoki Y, Kato K, Matoda M, Okamoto S, Nomura H, et al. Total Laparoscopic Resection Surgery for a Cervical Carcinoma that Recurred in the Pelvic Sidewall After Radical Hysterectomy and Adjuvant Concurrent Chemoradiotherapy. J Minim Invasive Gynecol. 2017;24:899-900 pubmed publisher
    ..A 48-year-old woman with stage IB2 cervical adenocarcinoma had undergone radical hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy,..
  8. Lin A, Kidd E, Dehdashti F, Siegel B, Mutic S, Thaker P, et al. Intensity Modulated Radiation Therapy and Image-Guided Adapted Brachytherapy for Cervix Cancer. Int J Radiat Oncol Biol Phys. 2019;103:1088-1097 pubmed publisher
    ..4 years). According to the International Federation of Gynecology and Obstetrics, 33% of tumors were stage IB1 to IB2, 41% were stage IIA to IIB, and 26% were stage IIIA to IVA...
  9. Kunos C, Radivoyevitch T, Kresak A, Dawson D, JACOBBERGER J, Yang B, et al. Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers. Int J Gynecol Cancer. 2012;22:1463-9 pubmed publisher
    ..Immunohistochemistry was performed on a tissue array comprised of 18 paired benign uterine cervix and stage IB2 cervical cancers to evaluate the relationship between cytosolic RNR M1, M2, and M2b staining intensity and ..

More Information

Publications120 found, 100 shown here

  1. Bhushan A, Singh A, Kapur S, Borthakar B, Sharma J, Rai A, et al. Identification and Validation of Fibroblast Growth Factor 12 Gene as a Novel Potential Biomarker in Esophageal Cancer Using Cancer Genomic Datasets. OMICS. 2017;21:616-631 pubmed publisher
    ..The protein interaction analysis of FGF12 found the binding with MAPK8IP2 and MAPK13...
  2. Angeles M, Baissas P, Leblanc E, Lusque A, Ferron G, Ducassou A, et al. Magnetic resonance imaging after external beam radiotherapy and concurrent chemotherapy for locally advanced cervical cancer helps to identify patients at risk of recurrence. Int J Gynecol Cancer. 2019;29:480-486 pubmed publisher
    ..77 patients (41.6%) were International Federation of Gynecology and Obstetrics stage IB2-IIA disease and 108 patients (58.4%) were stage IIB-IVA...
  3. Kalaghchi B, Abdi R, Amouzegar Hashemi F, Esmati E, Alikhasi A. Concurrent Chemoradiation with Weekly Paclitaxel and Cisplatin for Locally Advanced Cervical Cancer. Asian Pac J Cancer Prev. 2016;17:287-91 pubmed
    ..Women with primary untreated squamous cell carcinoma of the cervix with FIGO stages IB2 to IIIB were treated with weekly injections of cisplatin 30 mg/m2 and paclitaxel 35 mg/m2 for 5-6 weeks along with ..
  4. Lelievre L, Mathevet P. Para-aortic Lymphadenectomy for Gynecologic Cancers: Introducing the "Trans-Retro-Peritoneal (TRP) Single-Port Access". Ann Surg Oncol. 2019;: pubmed publisher
    ..with locally advanced cervical cancer (two International Federation of Gynecology and Obstetrics [FIGO] stage IB2, and one FIGO stage IVA) scheduled for concomitant radiochemotherapy after exclusion of any suspicious lymph nodes ..
  5. Cobos M, Aquilia L, Garay E, Ochiuzzi S, Alvarez S, Flores D, et al. Epidemiologic Study and Genotyping of BK Virus in Renal Transplant Recipients. Transplant Proc. 2018;50:458-460 pubmed publisher
    ..76%) from Ia, 10 (47.61%) from Ib1 and 10 (47.61%) from Ib2. Presence of subgroup Ic was not shown. Viremia presented in 33...
  6. Pellegrino A, Damiani G, Loverro M, Pirovano C, Fachechi G, Corso S, et al. Comparison of Robotic and laparoscopic Radical type-B and C hysterectomy for cervical cancer: Long term-outcomes. Acta Biomed. 2017;88:289-296 pubmed publisher
    ..C1 was performed in stage IB1, with a tumor size larger than 2 cm, or in patients previously treated with NACT (IB2). In all cases Pelvic lymphadenectomy was performed for the treatment of cervical cancer...
  7. Nogueira A, Assis J, Faustino I, Pereira D, Catarino R, Medeiros R. Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients. Biomarkers. 2017;22:70-76 pubmed publisher
    ..Two hundred and sixty adult patients, with histologically confirmed cervical cancer, at FIGO-stages IB2-IVA, primarily treated with concurrent chemotherapy (cisplatin) and radiotherapy...
  8. Morales F D, Medina R M, Trujillo L, Beltrán M, Dulcey I. Müllerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. Int J Surg Case Rep. 2016;27:155-161 pubmed publisher
    ..of the cervix with sarcomatous overgrowth, International Federation of Gynecology and Obstetrics (FIGO) stage IB2. She underwent abdominal radical hysterectomy and resection of the left external iliac lymph nodes for suspected ..
  9. Robova H, Halaska M, Pluta M, Skapa P, Matecha J, Lisy J, et al. Oncological and pregnancy outcomes after high-dose density neoadjuvant chemotherapy and fertility-sparing surgery in cervical cancer. Gynecol Oncol. 2014;135:213-6 pubmed publisher
    ..Two women underwent chemoradiotherapy for recurrence and lost chance for pregnancy. Downstaging by NAC in IB1 and IB2 cervical cancer before fertility-sparing surgery is still an experimental procedure, but shows some promise...
  10. Li Z, Li X, Xu L, Tao Y, Yang C, Chen X, et al. Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017;38:2705-2716 pubmed publisher
    ..of PAK4 by PCR array and found that 23 genes were upregulated (including TP53I3, TBX3, EEF1A2, CDKN1A, IFNB1 and MAPK8IP2) and 20 genes were downregulated (including TNFSF8, Bcl2-A1, Bcl2L1, SOCS3, BIRC3 and NFKB1) after PAK4 ..
  11. Ungar L, Palfalvi L, Tarnai L, Nechushkina V, Lintner B, Novak Z. Surgical treatment of stage IB cervical cancer. Int J Gynecol Cancer. 2012;22:1597-603 pubmed publisher
    ..factor that influenced the overall survival was International Federation of Gynecology and Obstetrics stage (IB1 or IB2). Five-year overall survival of 71 patients to whom adjuvant therapy was recommended was 56.3%...
  12. Rose P, Java J, Whitney C, Stehman F, Lanciano R, Thomas G. Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation. Gynecol Oncol. 2014;135:208-12 pubmed publisher
    ..9%). A higher percentage of adeno- and adenosquamous carcinomas were stage IB2 (27.5% versus 20.0%) and fewer had stage IIIB (21.4% versus 28.6%)...
  13. Jelavić T, Miše B, Strikic A, Ban M, Vrdoljak E. Adjuvant Chemotherapy in Locally Advanced Cervical Cancer After Treatment with Concomitant Chemoradiotherapy--Room for Improvement?. Anticancer Res. 2015;35:4161-5 pubmed
    ..and 2012, 118 patients diagnosed with LACC, The International Federation of Gynecology and Obstetrics (FIGO) stages IB2-IVA, regardless of histology, were treated with concomitant chemobrachyradiotherapy and consolidation chemotherapy ..
  14. Halaska M, Uzan C, Han S, Fruscio R, Dahl Steffensen K, Van Calster B, et al. Characteristics of patients with cervical cancer during pregnancy: a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy. Int J Gynecol Cancer. 2019;: pubmed publisher
    ..Stage distribution during pregnancy was 14.4% for stage IA, 47.0% for IB1, 18.9% for IB2, and 19.7% for II-IV. For treatment during pregnancy, 17.4% of the patients underwent surgery, 16...
  15. Vazquez Vicente D, Fernández Del Bas B, García Villayzán J, Di Fiore H, Luna Tirado J, Casado Echarren V, et al. Laparoscopic paraaortic surgical staging in locally advanced cervical cancer: a single-center experience. Clin Transl Oncol. 2018;20:1455-1459 pubmed publisher
    ..diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
  16. Chen T, Huang H, Wang T, Yang L, Chen C, Cheng Y, et al. Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study. Gynecol Oncol. 2015;137:468-73 pubmed publisher
    ..patients, primary radiation therapy with at least 5cycles of platinum-based chemotherapy (n=14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n=97, including 40 stages IB2-IIB) ..
  17. Salihi R, Leunen K, Van Limbergen E, Moerman P, Neven P, Vergote I. Neoadjuvant chemotherapy followed by large cone resection as fertility-sparing therapy in stage IB cervical cancer. Gynecol Oncol. 2015;139:447-51 pubmed publisher
    ..In this retrospective study we included 10 patients with FIGO stage IB1 and 1 patient with IB2 cervical cancer, who first received a pelvic lymphadenectomy followed by neoadjuvant chemotherapy and conization...
  18. Cai J, Yang L, Dong W, Wang H, Xiong Z, Wang Z. Retrospective comparison of laparoscopic versus open radical hysterectomy after neoadjuvant chemotherapy for locally advanced cervical cancer. Int J Gynaecol Obstet. 2016;132:29-33 pubmed publisher
    ..In a retrospective study, data were analyzed from patients with FIGO stage IB2-IIB cervical cancer who underwent LRH or ARH after NACT at Union Hospital, Wuhan, China, between January 2007 and ..
  19. Guo L, Wu H, Zhu J, Zhang C, Ma J, Lan J, et al. Genetic variations in the PI3K/AKT pathway predict platinum-based neoadjuvant chemotherapeutic sensitivity in squamous cervical cancer. Life Sci. 2015;143:217-24 pubmed publisher
    ..Akt1, Akt2, PTEN) were identified as being associated with chemotherapeutic response in 259 patients with stage IB2-IIB SCC. Each of these patients received more than two cycles of NAC...
  20. Kunos C, Radivoyevitch T, Abdul Karim F, Faulhaber P. 18F-fluoro-2-deoxy-D-glucose positron emission tomography standard uptake value ratio as an indicator of cervical cancer chemoradiation therapeutic response. Int J Gynecol Cancer. 2011;21:1117-23 pubmed publisher
    ..standard uptake values (SUVs) predicts progression-free survival after chemoradiation in patients with stages IB2 to IVA cervical cancer...
  21. Shim S, Lee S, Park J, Kim Y, Kim D, Kim J, et al. Risk assessment model for overall survival in patients with locally advanced cervical cancer treated with definitive concurrent chemoradiotherapy. Gynecol Oncol. 2013;128:54-59 pubmed publisher
    ..The median age was 55years (range, 26-78). Of the patients, 9, 16, 129, 3, 42 and 10 had FIGO stage IB2, IIA, IIB, IIIA, IIIB, and IVA disease, respectively...
  22. Lee K, Kim Y, Lee J. Oncologic outcomes of adjuvant chemotherapy alone after radical surgery for stage IB-IIA cervical cancer patients. J Gynecol Oncol. 2018;29:e5 pubmed publisher
    ..0 years (range, 23-73). Seventy-four patients (73.3%) were clinically staged as IB1; 23 and 4 patients as IB2 and IIA, respectively. The median number of retrieved pelvic and paraaortic LNs (PALNs) were 55...
  23. Ju U, Kang W, Kim S. Is the ovarian preservation safe in young women with stages IB-IIA villoglandular adenocarcinoma of the uterine cervix?. J Gynecol Oncol. 2018;29:e54 pubmed publisher
    ..6%), IA1 in 2, IA2 in 1, IB2 in 1, and IIA1 in 1...
  24. Wang W, Zhang F, Hu K, Hou X. Image-guided, intensity-modulated radiation therapy in definitive radiotherapy for 1433 patients with cervical cancer. Gynecol Oncol. 2018;151:444-448 pubmed publisher
    ..0%, 75.0%, and 87.4%, respectively. The 3-year DFS rates for patients with stages IB1, IB2, IIA, IIB, IIIA, IIIB, and IVA disease were 90.2%, 87.6%, 84.0%, 76.7%, 61.6%, 59.8%, and 25.9%...
  25. Vizza E, Chiofalo B, Cutillo G, Mancini E, Baiocco E, Zampa A, et al. Robotic single site radical hysterectomy plus pelvic lymphadenectomy in gynecological cancers. J Gynecol Oncol. 2018;29:e2 pubmed publisher
    ..FIGO) stage II, early cervical cancer (ECC) FIGO stage IB1 or locally advanced cervical cancer (LACC) FIGO stage IB2-IIB with clinical response ?50% after neo-adjuvant chemotherapy (NACT) were enrolled in a prospective cohort trial...
  26. Alongi F, Mazzola R, Ricchetti F, Fersino S, Levra N, Fiorentino A, et al. Volumetric-modulated arc therapy with vaginal cuff simultaneous integrated boost as an alternative to brachytherapy in adjuvant irradiation for endometrial cancer: a prospective study. Anticancer Res. 2015;35:2149-55 pubmed
    ..According to International Federation of Gynecology and Obstetrics 2009, the stages were: IB1 in 20%, IB2 in 28%, IIA2 in 16%, IIB in 6%, IIIA in 2%, and IIIC in 28%...
  27. Petrić Miše B, Boraska Jelavić T, Strikic A, Hrepić D, Tomić K, Hamm W, et al. Long follow-up of patients with locally advanced cervical cancer treated with concomitant chemobrachyradiotherapy with cisplatin and ifosfamide followed by consolidation chemotherapy. Int J Gynecol Cancer. 2015;25:315-9 pubmed publisher
    ..We treated 118 patients with LACC (International Federation of Gynecology and Obstetrics stages IB2-IVA) with external radiotherapy (50 Gy in 25 fractions) and concomitant chemobrachyradiotherapy (low-dose rate)...
  28. Shrivastava S, Lewis S, Sastri S, Lavanya G, Mahantshetty U, Engineer R. Cancer cervix: Establishing an evidence-based strategy, an experience of a tertiary care centre in India. Curr Probl Cancer. 2018;42:137-147 pubmed publisher
    ..For stages IB2 to IV, concurrent chemoradiation is advocated with improvement in overall survival proven with randomized trials...
  29. Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, et al. The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010;29:236-50 pubmed publisher
    ..for binding to PHCCEx domain, Motif-I in CD44 and ephrinB's and the NMDA receptor, and Motif-II in Par3 and JIP2. Our results suggest the molecular basis by which the Tiam1/2 PHCCEx domain facilitates dual binding to membranes ..
  30. Descamps V, Martin E, Morel V, François C, Helle F, Duverlie G, et al. Comparative Evaluation of Three Nucleic Acid-Based Assays for BK Virus Quantification. J Clin Microbiol. 2015;53:3822-7 pubmed publisher
    ..The greatest variability between assays was observed for 10.2% of subtype Ib2 samples, with differences of >1 log10 copies/ml...
  31. Cibula D, Pinkavova I, Dusek L, Slama J, Zikan M, Fischerova D, et al. Local control after tailored surgical treatment of early cervical cancer. Int J Gynecol Cancer. 2011;21:690-8 pubmed publisher
    ..Different prognostic parameters were observed for stages IB1/IB2 and IIA/B.
  32. Castelnau Marchand P, Chargari C, Maroun P, Dumas I, Del Campo E, Cao K, et al. Clinical outcomes of definitive chemoradiation followed by intracavitary pulsed-dose rate image-guided adaptive brachytherapy in locally advanced cervical cancer. Gynecol Oncol. 2015;139:288-94 pubmed publisher
    ..5 for IB2, 85.8% for IIB, 50% for IIIA, 77.1 for IIIB, and 66.7% for IVA tumors (p=0.06)...
  33. Huang Z, Yuh K, Lo S, Grecula J, Sammet S, Sammet C, et al. Validation of optimal DCE-MRI perfusion threshold to classify at-risk tumor imaging voxels in heterogeneous cervical cancer for outcome prediction. Magn Reson Imaging. 2014;32:1198-205 pubmed publisher
    ..DCE-MRI from 102 patients with stage IB2-IVB cervical cancer was obtained at 3 different treatment time points: before (MRI 1) and during treatment (MRI 2 ..
  34. Liu Z, Li X, Tao Y, Li W, Yang Y, Yao Y, et al. Clinical efficacy and safety of laparoscopic nerve-sparing radical hysterectomy for locally advanced cervical cancer. Int J Surg. 2016;25:54-8 pubmed publisher
    ..120 patients with stage Ib2 and IIa2 cervical cancer were treated with surgery combined with preoperative NACT in the Department of Obstetrics ..
  35. Kobayashi E, Iwamiya T, Isobe M, Miyake T, Shiki Y, Yamasaki M. A novel technique for the management of the vesicouterine ligament during radical hysterectomy. Gynecol Oncol. 2009;115:56-59 pubmed publisher
    ..to 2006, 35 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage IB1 (n=32) and IB2 (n=3) invasive cervical cancer underwent radical hysterectomy...
  36. Roma A, Mistretta T, Diaz de Vivar A, Park K, Alvarado Cabrero I, Rasty G, et al. New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome. Gynecol Oncol. 2016;141:36-42 pubmed publisher
    ..9%) and 17% were stage II or greater. Forty-five (23.8%) patients showed LN metastases (one IA1, 14 IB1, 5 IB2, 5 IB NOS, 11 II, 5 III and 4 IV) and recurrences were recorded in 41 (21.7%) patients...
  37. Lamblin G, Chauvy L, Rannou C, Mathevet P, Chabert P, Mellier G, et al. Does ultrasonic advanced energy reduce lymphocele incidence in laparoscopic para-aortic lymphadenectomy?. Eur J Obstet Gynecol Reprod Biol. 2015;185:53-8 pubmed publisher
    ..The main indication (90% in group 1, 61% in group 2) was advanced cervical carcinoma (stage IB2 and above). Ultrasonic advanced energy significantly decreased operative time (p=0...
  38. De Vincenzo R, Tortorella L, Ricci C, Cavaliere A, Zannoni G, Cefalo M, et al. Locally advanced cervical cancer complicating pregnancy: A case of competing risks from the Catholic University of the Sacred Heart in Rome. Gynecol Oncol. 2018;150:398-405 pubmed publisher
    A case of stage IB2 cervical cancer at 27 weeks of pregnancy, treated with neoadjuvant chemotherapy followed by radical Cesarean hysterectomy with full pelvic and infra-mesenteric lymphadenectomy, and adjuvant chemo-radiation is ..
  39. Kumar L, Pramanik R, Kumar S, Bhatla N, Malik S. Neoadjuvant chemotherapy in gynaecological cancers - Implications for staging. Best Pract Res Clin Obstet Gynaecol. 2015;29:790-801 pubmed publisher
    ..Neoadjuvant chemotherapy followed by surgery is associated with improved survival for women with stage IB2-IIA cervix cancer...
  40. Jang T, Shin S, Chung H, Kwon S, Cha S, Lee E, et al. A retrospective comparison of outcome in IB2 and IIA cervical cancer patients treated with primary concurrent chemoradiation versus radical hysterectomy with or without tailored adjuvant therapy. Obstet Gynecol Sci. 2017;60:549-557 pubmed publisher
    ..radical hysterectomy (RH) with or without tailored adjuvant therapy in patients with stages IB2 and IIA cervical cancer.
  41. Li F, Wu Y, Kong W, Wang J, Hao X, Niu J, et al. Clinical efficacy of preoperative vaginal intracavitary irradiation for Stage Ib2 and IIa cervical cancer. J Cancer Res Ther. 2017;13:796-800 pubmed publisher
    The purpose of this study was to evaluate the clinical efficacy of preoperative vaginal intracavitary irradiation for Stage Ib2 and IIa cervical cancer.
  42. Chen C, Wang L, Lin J, Jan J. The prognostic factors for locally advanced cervical cancer patients treated by intensity-modulated radiation therapy with concurrent chemotherapy. J Formos Med Assoc. 2015;114:231-7 pubmed publisher
    ..A total of 125 patients with stage IB2-III cervical carcinoma were treated with IMRT and concurrent cisplatin-based chemotherapy, plus high dose rate (HDR)..
  43. Shoji T, Takatori E, Furutake Y, Takada A, Nagasawa T, Omi H, et al. Phase II clinical study of neoadjuvant chemotherapy with CDDP/CPT-11 regimen in combination with radical hysterectomy for cervical cancer with a bulky mass. Int J Clin Oncol. 2016;21:1120-1127 pubmed
    ..The subjects were 42 patients with stages IB2 to IIIB squamous cell carcinoma of the uterine cervix with a bulky mass...
  44. Gallotta V, Chiantera V, Conte C, Vizzielli G, Fagotti A, Nero C, et al. Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study. J Minim Invasive Gynecol. 2017;24:133-139 pubmed publisher
    ..January 2016, a total of 40 patients with LACC (Fédération Internationale de Gynécologie et d'Obstétrique stage IB2-III) were enrolled in the study...
  45. Baiocchi G, De Brot L, Faloppa C, Mantoan H, Duque M, Badiglian Filho L, et al. Is parametrectomy always necessary in early-stage cervical cancer?. Gynecol Oncol. 2017;146:16-19 pubmed publisher
    ..We analyzed a series of 345 patients with stage Ia2 to Ib2 cervical cancer, for which they underwent radical surgery from January 1990 to October 2016 at AC Camargo Cancer ..
  46. Mongula J, Bakers F, Voo S, Lutgens L, Van Gorp T, Kruitwagen R, et al. Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study. EJNMMI Res. 2018;8:1 pubmed publisher
    ..Ten patients with cervical carcinoma (FIGO ?IB2) were prospectively evaluated...
  47. Espenel S, Garcia M, Trone J, Guillaume E, Harris A, Rehailia Blanchard A, et al. From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience. Radiat Oncol. 2018;13:16 pubmed publisher
    ..6% IB2, 22.3% IIA, 51.0% IIB, 4.3% IIIA and 11.7% IIIB. Pelvic lymph nodes were involved in 34.0% of cases...
  48. Ferrandina G, Palluzzi E, Gallotta V, Gambacorta M, Autorino R, Turco L, et al. Neo-adjuvant platinum-based chemotherapy followed by chemoradiation and radical surgery in locally advanced cervical cancer (Lacc) patients: A phase II study. Eur J Surg Oncol. 2018;44:1062-1068 pubmed publisher
    ..The primary end point was rate of pathologic complete response (pCR). FIGO Stage IB2-IVA patients were administered NACT chemotherapy (paclitaxel 80 mg/m2, carboplatin AUC 2), for 6 weeks, ..
  49. Lekskul N, Charakorn C, Lertkhachonsuk A, Rattanasiri S, Israngura Na Ayudhya N. The Level of Squamous Cell Carcinoma Antigen and Lymph Node Metastasis in Locally Advanced Cervical Cancer. Asian Pac J Cancer Prev. 2015;16:4719-22 pubmed
    ..From June 2009 to June 2014, 232 patients with cervical cancer stage IB2-IVA, who were treated at Ramathibodi Hospital, were recruited...
  50. Wang S, Mu N, Sun H. Effect of Interventional Therapy on the Expression of Survivin mRNA in Cervical Cancer. Anticancer Res. 2017;37:4707-4710 pubmed
    ..Fifty patients with stage IB2-IIB cervical squamous cancer receiving transarterial infusion chemotherapy and chemoembolization were included in ..
  51. Gallotta V, Ferrandina G, Chiantera V, Fagotti A, Fanfani F, Ercoli A, et al. Laparoscopic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study. J Minim Invasive Gynecol. 2015;22:877-83 pubmed publisher
    ..Prospective phase II study (Canadian Task Force classification II-1). Patients with LACC (FIGO stage IB2-III) were evaluated for accrual at the Gynecologic Oncology Unit of Catholic University, Rome/Campobasso...
  52. Zhu X, Wu M, Tan X, Yu Q. [Clinical study of 16 cases of villoglandular adenocarcinoma of uterine cervix]. Zhonghua Yi Xue Za Zhi. 2015;95:519-22 pubmed
    ..And the International Federation of Gynecology and Obstetrics (FIGO) stages were Ia1 (n = 1),Ib1 (n = 12),Ib2 (n = 2) and IIa1 (n = 1)...
  53. Vandeperre A, Van Limbergen E, Leunen K, Moerman P, Amant F, Vergote I. Para-aortic lymph node metastases in locally advanced cervical cancer: Comparison between surgical staging and imaging. Gynecol Oncol. 2015;138:299-303 pubmed publisher
    ..Monocentric retrospective study of 336 patients with cervical cancer FIGO stage IB2-IVA. All patients underwent staging of the PAOLN using imaging by PET-CT, PET or CT...
  54. Okame S, Kojima A, Teramoto N, Shiroyama Y, Yokoyama T, Takehara K, et al. Type C2 radical hysterectomy may improve outcomes of locally advanced mucinous adenocarcinoma of the uterine cervix. Int J Clin Oncol. 2016;21:723-729 pubmed publisher
    ..records and pathological materials of 32 patients with International Federation of Gynecology and Obstetrics stage IB2-IIB mucinous adenocarcinoma, who had undergone radiotherapy or radical hysterectomy as primary treatment between ..
  55. Cihoric N, Tsikkinis A, Vlaskou Badra E, Glatzer M, Novak U, Scherz A, et al. Highly conformal combined radiotherapy with cisplatin and gemcitabine for treatment of loco-regionally advanced cervical cancer - a retrospective study. Radiat Oncol. 2017;12:202 pubmed publisher
    ..Seventeen patients with cervical carcinoma FIGO stage IB2-IIIB were treated with curative intent between 2011 and 2015. A total dose of 50...
  56. Signorelli M, Bogani G, Chiappa V, Ditto A, Scaffa C, Martinelli F, et al. Ovarian preservation in locally advanced cervical cancer undergoing neoadjuvant chemotherapy and radical surgery. Minerva Ginecol. 2018;70:357-363 pubmed publisher
    ..Retrospective evaluation of consecutive patients affected by LACC (stage IB2-IIB), treated by NACT followed by radical surgery at National Cancer Institute, Milan, Italy, between 1990-2015...
  57. Tantivatana T, Rongsriyam K. Treatment outcomes of high-dose-rate intracavitary brachytherapy for cervical cancer: a comparison of Ir-192 versus Co-60 sources. J Gynecol Oncol. 2018;29:e86 pubmed publisher
    ..treatment outcomes between cobalt-60 (Co-60) and iridium-192 (Ir-192) high dose rate (HDR) brachytherapy in stage IB2-IIIB cervical cancer patients at Department of Radiology, Faculty of Medicine Vajira Hospital, Navamindrahiraj ..
  58. Papadia A, Bellati F, Bogani G, Ditto A, Martinelli F, Lorusso D, et al. When Does Neoadjuvant Chemotherapy Really Avoid Radiotherapy? Clinical Predictors of Adjuvant Radiotherapy in Cervical Cancer. Ann Surg Oncol. 2015;22 Suppl 3:S944-51 pubmed publisher
    ..series of cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB2-IIB treated with NACT followed by radical surgery was analyzed...
  59. Bhosale P, Iyer R, Ramalingam P, Schmeler K, Wei W, Bassett R, et al. Is MRI helpful in assessing the distance of the tumour from the internal os in patients with cervical cancer below FIGO Stage IB2?. Clin Radiol. 2016;71:515-22 pubmed publisher
    ..5% and an accuracy of 91.4% for the subset analysis. MRI has high specificity, NPV, and accuracy in detecting tumour from the IO, making MRI suitable for treatment planning in patients desiring trachelectomy to preserve fertility. ..
  60. Chong G, Lee Y, Han H, Lee H, Park J, Hong D, et al. Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer. Gynecol Oncol. 2018;148:97-102 pubmed publisher
    ..of Gynecology and Obstetrics (FIGO) stage IB1-IIA cervical cancer, and 140 were treated with CCRT for FIGO stage IB2-IV cervical cancer. HPV 16 and 18 were the two most common HPV types detected, with prevalence rates of 52...
  61. Robova H, Rob L, Halaska M, Pluta M, Skapa P, Strnad P, et al. High-dose density neoadjuvant chemotherapy in bulky IB cervical cancer. Gynecol Oncol. 2013;128:49-53 pubmed publisher
    ..Three patients were withdrawn. Of the 151 women, 119 had stage IB2 cervical cancer (78.8%) and 32 had stage IB1 cancer (21.2%) infiltrating the whole cervical stroma...
  62. Martinelli F, Bogani G, Ditto A, Carcangiu M, Papadia A, Lecce F, et al. How often parametrial involvement leads to post-operative adjuvant treatment in locally advanced cervical cancer after neoadjuvant chemotherapy and type C radical hysterectomy?. Eur J Surg Oncol. 2015;41:1089-96 pubmed publisher
    ..Retrospective evaluation of consecutive 275 patients affected by LACC (IB2-IIB), undergoing NACT followed by type C/class III radical hysterectomy...
  63. Bendifallah S, de Foucher T, Ouldamer L, Bricou A, Lavoue V, Varinot J, et al. Comparison of pelvic and para-aortic lymphadenectomy versus para-aortic lymphadenectomy alone for locally advanced FIGO stage IB2 to IIB cervical cancer using a propensity score matching analysis: Results from the FRANCOGYN study group. Eur J Surg Oncol. 2018;44:1921-1928 pubmed publisher
    ..The aim of this study was to compare the prognosis of women with FIGO stage IB2-IIB CC who underwent surgical nodal staging including either exclusive para-aortic lymphadenectomy (PAL) or ..
  64. Viswanathan A, Erickson B, Gaffney D, Beriwal S, Bhatia S, Lee Burnett O, et al. Comparison and consensus guidelines for delineation of clinical target volume for CT- and MR-based brachytherapy in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys. 2014;90:320-8 pubmed publisher
    ..with a tandem and ovoid, 1 stage IIB partial response (PR) case with tandem and ovoid with needles, and 1 stage IB2 CR case with a tandem and ring applicator. The CT contours were completed before the MRI contours...
  65. Winer I, Alvarado Cabrero I, Hassan O, Ahmed Q, Alosh B, Bandyopadhyay S, et al. The prognostic significance of histologic type in early stage cervical cancer - A multi-institutional study. Gynecol Oncol. 2015;137:474-8 pubmed publisher
    ..Retrospective analysis of patients with SCC (148 patients) and ADC (130 patients) stages IA1-IB2 who underwent surgery at our three institutions (two from Detroit, one from Mexico) from 2000-2010 was performed ..
  66. Liu Z, Li X, Li W, Yang Y, Tao Y, Yao Y. Robotic nerve-sparing radical hysterectomy for locally advanced cervical cancer after neoadjuvant chemotherapy. Int J Gynaecol Obstet. 2015;131:152-5 pubmed publisher
    ..early-stage disease (FIGO stage IA2-IB1) who were treated by robotic surgery (group 1), and those with LACC (stage IB2-IIB) who were treated by robotic surgery after neoadjuvant chemotherapy (NACT; group 2)...
  67. Huertas A, Oldrini S, Nesseler J, Courrech F, Retif P, Charra Brunaud C, et al. FIGO stage IB1 cervical carcinoma: Place and principles of brachytherapy. Cancer Radiother. 2017;21:155-163 pubmed publisher
    The treatment of cervical cancers according to FIGO staging is well defined. For FIGO stage IB2 or more, chemoradiotherapy followed by uterovaginal brachytherapy boost is the standard treatment...
  68. de la Rochefordiere A, Kamal M, Floquet A, Thomas L, Petrow P, Petit T, et al. PIK3CA Pathway Mutations Predictive of Poor Response Following Standard Radiochemotherapy ± Cetuximab in Cervical Cancer Patients. Clin Cancer Res. 2015;21:2530-7 pubmed publisher
    ..This randomized phase II trial enrolled 78 FIGO stage IB2-IIIB cervical cancer patients to either cisplatin-based radiochemotherapy alone (arm B, n = 38) or conjointly with ..
  69. Yang Z, Chen D, Zhang J, Yao D, Gao K, Wang H, et al. The efficacy and safety of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer: A randomized multicenter study. Gynecol Oncol. 2016;141:231-239 pubmed publisher
    ..to evaluate the toxicity and curative effect of irinotecan plus cisplatin neoadjuvant chemotherapy (NACT) for stage Ib2, IIa2, and IIb cervical cancer patients...
  70. Ramondetta L, Meyer L, Schmeler K, Daheri M, Gallegos J, Scheurer M, et al. Avoidable tragedies: Disparities in healthcare access among medically underserved women diagnosed with cervical cancer. Gynecol Oncol. 2015;139:500-5 pubmed publisher
    ..IB1) and those diagnosed at a stage requiring local-regional or systemic/palliative treatment (≥IB2). Among the 138 women, 21.7% were diagnosed with ≤lB1 disease, while 78...
  71. Hoogendam J, Kalleveen I, de Castro C, Raaijmakers A, Verheijen R, van den Bosch M, et al. High-resolution T2-weighted cervical cancer imaging: a feasibility study on ultra-high-field 7.0-T MRI with an endorectal monopole antenna. Eur Radiol. 2017;27:938-945 pubmed publisher
    ..Patients had stage IB1 (n = 9), IB2 (n = 4), IIA1 (n = 1) or IIB (n = 6) cervical cancer...
  72. Ji S, Hu Q, Zhu J, Chen J, Chen Q, Liu Z, et al. Combined pretreatment with 18F-FDG PET/CT and Comet assay guides the concurrent chemoradiotherapy of locally advanced cervical cancer: study protocol for a randomized controlled trial. Trials. 2018;19:416 pubmed publisher
    ..Three hundred cervical cancer patients with FIGO stages IB2-IVA and no para-aortic lymphadenopathy (> 10 mm) will be enrolled...
  73. Ran J, Lin D, Wu R, Chen Q, Huang H, Qiu N, et al. ZEB1 promotes epithelial-mesenchymal transition in cervical cancer metastasis. Fertil Steril. 2015;103:1606-14.e1-2 pubmed publisher
    ..Exploratory study. University hospital. Sixty patients with SCC, including stage CINIII (n = 10), IB1 (n = 10), IB2 (n = 10), IIA1 (n = 10), IIA2 (n = 10), and IIB (n = 10) were studied...
  74. Churilla T, Egleston B, Dong Y, Shaikh T, Murphy C, Mantia Smaldone G, et al. Disparities in the management and outcome of cervical cancer in the United States according to health insurance status. Gynecol Oncol. 2016;141:516-523 pubmed publisher
    ..with definitive surgery for FIGO IA2-IB1 patients, and treatment with suboptimal radiation therapy (RT) for FIGO IB2-IVA patients (other than combination external beam and brachytherapy)...
  75. Lee J, Lin J, Chang C, Jan Y, Sun F, Wu M, et al. Prophylactic lower para-aortic irradiation using intensity-modulated radiotherapy mitigates the risk of para-aortic recurrence in locally advanced cervical cancer: A 10-year institutional experience. Gynecol Oncol. 2017;146:20-26 pubmed publisher
    ..A total of 206 patients with FIGO stage IB2-IVA cervical cancer and negative para-aortic lymph nodes (PALNs) who underwent pelvic IMRT (PRT) or SRVRT between ..
  76. de Azevedo C, Thuler L, de Mello M, de Oliveira Lima J, da Fonte A, Fontão D, et al. Phase II trial of neoadjuvant chemotherapy followed by chemoradiation in locally advanced cervical cancer. Gynecol Oncol. 2017;146:560-565 pubmed publisher
    ..Locally advanced cervical cancer patients (Ib2-IVa) were treated with neoadjuvant cisplatin 35mg/m2 and gemcitabine 1000mg/m2 D1 and D8, for ..
  77. del Carmen M, Pareja R, Melamed A, Rodríguez J, Greer A, Clark R, et al. Isolated para-aortic lymph node metastasis in FIGO stage IA2-IB2 carcinoma of the cervix: Revisiting the role of surgical assessment. Gynecol Oncol. 2018;150:406-411 pubmed publisher
    ..lymph node dissection among women undergoing radical hysterectomy and pelvic lymph adenectomy for FIGO Stage IA2-IB2 cervical cancer using the National Cancer Database (NCDB)...
  78. Ferrandina G, Gambacorta A, Gallotta V, Smaniotto D, Fagotti A, Tagliaferri L, et al. Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study. Int J Radiat Oncol Biol Phys. 2014;90:778-85 pubmed publisher
    ..response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer...
  79. Zhang T, Kong W, Li F, Song D, Liu T, Han C, et al. Effect of preoperative radiotherapy on stage IB2 and IIA2 cervical cancer: A retrospective cohort study. Int J Surg. 2016;30:63-7 pubmed publisher
    ..combined with radical surgery on postoperative complications and long-term survival in patients with stage IB2 and IIA2 cervical cancer (CC)...
  80. Slama J, Černý A, Dusek L, Fischerova D, Zikan M, Kocian R, et al. Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5years of experience. Gynecol Oncol. 2016;142:401-4 pubmed publisher
    ..Included were women with cervical cancer stages IA2-IB2 who were under the age of 40 and desired future pregnancy...
  81. Wu S, Lu S, Tao H, Zhang L, Lin W, Shang H, et al. Correlation of polymorphism of IL-8 and MMP-7 with occurrence and lymph node metastasis of early stage cervical cancer. J Huazhong Univ Sci Technolog Med Sci. 2011;31:114-119 pubmed publisher
    ..05); (3) The incidence of IL-8 mutation was two times higher in IIa cervical cancer group than in Ib1 and Ib2 cervical cancer group (P=0.006)...
  82. Kim S, Lim M, Lee J, Kim Y, Seo S, Kang S, et al. Comparison of Lower Extremity Edema in Locally Advanced Cervical Cancer: Pretreatment Laparoscopic Surgical Staging with Tailored Radiotherapy Versus Primary Radiotherapy. Ann Surg Oncol. 2016;23:203-10 pubmed publisher
    ..In total, 79 cervical cancer survivors with International Federation of Gynecology and Obstetrics stage IB2-IIB were included...
  83. Ngo C, Samuels S, Bagrintseva K, Slocker A, Hupé P, Kenter G, et al. From prospective biobanking to precision medicine: BIO-RAIDs - an EU study protocol in cervical cancer. BMC Cancer. 2015;15:842 pubmed publisher
    ..Tumor and liquid biopsies from patients with previously non-treated cervical cancer (stages IB2-IV) are collected at defined time points...
  84. Liang Y, Lü B, Chen X, Qin J, Cheng X, Xie X, et al. Prognostic value of pathological response to neoadjuvant chemotherapy in bulky stage Ib2 and IIa cervical squamous cell cancer patients. Virchows Arch. 2016;468:329-36 pubmed publisher
    ..We included in the study 190 patients with bulky stage Ib2 or IIa cervical squamous cell cancer, who underwent neoadjuvant chemotherapy followed by surgery...
  85. Zanagnolo V, Minig L, Cardenas Rebollo J, Achilarre M, Garbi A, Patrono M, et al. Robotic Versus Open Radical Hysterectomy in Women With Locally Advanced Cervical Cancer After Neoadjuvant Chemotherapy: A Single-institution Experience of Surgical and Oncologic Outcomes. J Minim Invasive Gynecol. 2016;23:909-16 pubmed publisher
    ..study was performed in 30 patients with LACC Fédération Internationale de Gynécologie et d'Obstétrique stage IB2-IIB who underwent RRH after NACT between February 2008 and December 2014...
  86. Peng C, Liu L, Zheng W, Xie Y, Xiong Y, Li A, et al. Can quantitative contrast-enhanced ultrasonography predict cervical tumor response to neoadjuvant chemotherapy?. Eur J Radiol. 2016;85:2111-2118 pubmed publisher
    ..Thirty-eight cases with stage IB2 or IIA cervical cancer were studied using CEUS before and after one cycle of NACT...
  87. Jouglar E, Thomas L, de la Rochefordiere A, Noel G, Le Blanc Onfroy M, Delpon G, et al. Toxicity and early clinical outcomes in cervical cancer following extended field helical tomotherapy to para-aortic lymph nodes. Cancer Radiother. 2016;20:794-800 pubmed publisher
    ..Thirty-eight patients (International Federation of Gynecology and Obstetrics [FIGO] stage IB2-IVA) from four institutions received extended-field helical tomotherapy and were retrospectively evaluated...
  88. Gadducci A, Landoni F, Cosio S, Zizioli V, Zola P, Ferrero A, et al. Neoadjuvant Platinum-based Chemotherapy Followed by Radical Hysterectomy for Stage Ib2-IIb Adenocarcinoma of the Uterine Cervix - An Italian Multicenter Retrospective Study. Anticancer Res. 2018;38:3627-3634 pubmed publisher
    ..Data were retrospectively analyzed for 82 patients with International Federation of Gynecology and Obstetrics stage Ib2-IIb cervical adenocarcinoma who underwent this chemo-surgical treatment...
  89. Zamaniah W, Mastura M, Phua C, Adlinda A, Marniza S, Rozita A. Definitive concurrent chemoradiotherapy in cervical cancer--a University of Malaya Medical Centre experience. Asian Pac J Cancer Prev. 2014;15:8987-92 pubmed
    ..A cohort of 60 patients with FIGO stage IB2-IVA cervical cancer who were treated with definitive concurrent chemoradiotherapy with cisplatin followed by ..
  90. Patankar S, Tergas A, Deutsch I, Burke W, Hou J, Ananth C, et al. High versus low-dose rate brachytherapy for cervical cancer. Gynecol Oncol. 2015;136:534-41 pubmed publisher
    ..Women with stages IB2-IVA cervical cancer treated with primary (external beam and brachytherapy) radiotherapy between 2003-2011 and ..
  91. Monnier L, Touboul E, Daraï E, Lefranc J, Lauratet B, Ballester M, et al. [Stage IB2, IIA and IIB cervical carcinoma without lymph node extension treated with neoadjuvant chemoradiotherapy]. Bull Cancer. 2016;103:164-72 pubmed publisher
    ..Between 2000 and 2010, 45 patients with cervical carcinoma stage IB2 (11 patients), IIA2 (3 patients) and IIB with proximal parametrial invasion (31 patients) were treated with pelvic ..
  92. Martinelli F, Signorelli M, Bogani G, Ditto A, Chiappa V, Perotto S, et al. Is aortic lymphadenectomy indicated in locally advanced cervical cancer after neoadjuvant chemotherapy followed by radical surgery? A retrospective study on 261 women. Eur J Surg Oncol. 2016;42:1512-8 pubmed publisher
    ..Retrospective evaluation of consecutive 261 patients affected by LACC (stage IB2-IIB), treated with NACT followed by radical surgery at National Cancer Institute, Milan, Italy, between 1990 and ..