MAPK12

Summary

Gene Symbol: MAPK12
Description: mitogen-activated protein kinase 12
Alias: ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3, mitogen-activated protein kinase 12, MAP kinase 12, MAP kinase p38 gamma, extracellular signal-regulated kinase 6, mitogen-activated protein kinase 3, mitogen-activated protein kinase p38 gamma, stress-activated protein kinase 3
Species: human
Products:     MAPK12

Top Publications

  1. Déléris P, Trost M, Topisirovic I, Tanguay P, Borden K, Thibault P, et al. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem. 2011;286:6470-8 pubmed publisher
    ..The atypical MAP kinases extracellular signal-regulated kinase 3 (ERK3) and ERK4 contain a single phospho-acceptor site in this segment and are not substrates of MAP kinase kinases...
  2. Soulez M, Saba El Leil M, Turgeon B, Mathien S, Coulombe P, Klinger S, et al. Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Mol Cell Biol. 2019;39: pubmed publisher
    ..The physiological functions of the atypical mitogen-activated protein kinase extracellular signal-regulated kinase 3 (ERK3) remain poorly characterized...
  3. Kumar A, Anuppalle M, Maddirevula S, Huh T, Choe J, Rhee M. Peli1b governs the brain patterning via ERK signaling pathways in zebrafish embryos. Gene. 2019;694:1-6 pubmed publisher
    ..Finally, the ERK3/4 inhibitor SB203580 also induced a significant reduction in the level of zic3 transcripts in the neural plate at 6..
  4. Kostenko S, Shiryaev A, Gerits N, Dumitriu G, Klenow H, Johannessen M, et al. Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function. Cell Mol Life Sci. 2011;68:847-62 pubmed publisher
    ..predominantly in the nucleus of resting cells, but p38(MAPK), extracellular signal-regulated kinases-3 and -4 (ERK3 and ERK4), and protein kinase A (PKA) induce nucleocytoplasmic redistribution of MK5...
  5. Ronkina N, Schuster Gossler K, Hansmann F, Kunze Schumacher H, Sandrock I, Yakovleva T, et al. Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3. Mol Cell Biol. 2019;39: pubmed publisher
    Mitogen-activated protein kinase 6/extracellular signal-regulated kinase 3 (MAPK6/ERK3) is an atypical member of the MAPKs...
  6. Prochazka R, Nemcova L. Mechanisms of FSH- and Amphiregulin-Induced MAP Kinase 3/1 Activation in Pig Cumulus-Oocyte Complexes During Maturation In Vitro. Int J Mol Sci. 2019;20: pubmed publisher
    ..This rapid activation of MAPK3/1 precedes the second mechanism participating in the generation and maintenance of active MAPK3/1-the ligand-dependent activation of EGFR depending on the synthesis of EGF-like peptides. ..
  7. Chen M, Myers A, Markey M, Long W. The atypical MAPK ERK3 potently suppresses melanoma cell growth and invasiveness. J Cell Physiol. 2019;234:13220-13232 pubmed publisher
    ..protein kinase 6 (MAPK6) represents an atypical MAPK also known as extracellular signal-regulated kinase 3 (ERK3), which has been shown to play roles in cell motility and metastasis...
  8. Kumari P, Dwivedi H, Baidya M, Shukla A. Measuring agonist-induced ERK MAP kinase phosphorylation for G-protein-coupled receptors. Methods Cell Biol. 2019;149:141-153 pubmed publisher
    ..Note: ERK1/2 is also referred to as p44/42 MAP kinase. ERK1 and ERK2 are same as Mitogen-Activated Protein Kinase 3 (MAP3) and Mitogen-Activated Protein Kinase 1 (MAP1), respectively. ..
  9. Minutoli L, Antonuccio P, Polito F, Bitto A, Squadrito F, Di Stefano V, et al. Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner. Eur J Pharmacol. 2009;604:27-35 pubmed publisher
    ..These findings should contribute to better understand testicular torsion-induced damage. ..

More Information

Publications130 found, 100 shown here

  1. Pogozelski A, Geng T, Li P, Yin X, Lira V, Zhang M, et al. p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS ONE. 2009;4:e7934 pubmed publisher
    ..Using muscle-specific gene deletion in mice, we now show that p38gamma mitogen-activated protein kinase (MAPK), but not p38alpha and p38beta, is required for endurance exercise-induced ..
  2. Dingar D, Benoit M, Mamarbachi A, Villeneuve L, Gillis M, Grandy S, et al. Characterization of the expression and regulation of MK5 in the murine ventricular myocardium. Cell Signal. 2010;22:1063-75 pubmed publisher
    ..Whereas MK2 and MK3 are activated by p38 MAPK, MK5 has also been shown to be activated by ERK3 and ERK4. We studied the regulation of MK5 in mouse heart. mRNA for 5 splice variants (MK5.1-5...
  3. Li X, Zhou C, Sun Y, Su Z, Wang X, N Jia E, et al. Bioinformatic analysis of potential candidates for therapy of inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2015;19:4275-84 pubmed
    ..MAPK3, NDRG1 and HLA-DRA may play key roles in the progression and development of IBD. They may be used as specific therapeutic targets in the treatment of IBD. However, further experiments are still needed to confirm our results. ..
  4. Li H, Ding Y, Shi Y, Zhang X, Zhang S, Gong Z, et al. MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis. Dev Cell. 2017;43:630-642.e4 pubmed publisher
    ..These combined results indicate that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants. ..
  5. Berdouses E, Oulis C, Michalaki M, Tripoliti E, Fotiadis D. Histological validation of the automated caries detection system (ACDS) in classifying occlusal caries with the ICDAS II system in vitro. Eur Arch Paediatr Dent. 2018;: pubmed publisher
    ..87 and 0.89 while the inter-examiner for the two trials were 0.87 and 0.92. The ICDAS3-ERK3 combination between the ACDS and histological sections presented the best agreement with kappa coefficient 0...
  6. Aberg E, Torgersen K, Johansen B, Keyse S, Perander M, Seternes O. Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif. J Biol Chem. 2009;284:19392-401 pubmed publisher
    b>ERK3 and ERK4 are atypical MAPKs in which the canonical TXY motif within the activation loop of the classical MAPKs is replaced by SEG. Both ERK3 and ERK4 bind, translocate, and activate the MAPK-activated protein kinase (MK) 5...
  7. Brand F, Schumacher S, Kant S, Menon M, Simon R, Turgeon B, et al. The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Mol Cell Biol. 2012;32:2467-78 pubmed publisher
    ..protein (MAPKAP) kinase 5 (MK5) deficiency is associated with reduced extracellular signal-regulated kinase 3 (ERK3) (mitogen-activated protein kinase 6) levels, hence we utilized the MK5 knockout mouse model to analyze the ..
  8. Lindin I, Wuxiuer Y, Ravna A, Moens U, Sylte I. Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5. Int J Mol Sci. 2014;15:4878-902 pubmed publisher
    ..protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4...
  9. Yamaguchi R, Kawata J, Yamamoto T, Ishimaru Y, Sakamoto A, Ono T, et al. Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps. Blood Cells Mol Dis. 2015;55:127-33 pubmed publisher
    ..Interestingly, a combined p38gamma and p38delta inhibitor (BIRB796) significantly decreased IFN-gamma production...
  10. Maisonneuve P, Caillet Saguy C, Raynal B, Gilquin B, Chaffotte A, Pérez J, et al. Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain. FEBS J. 2014;281:4852-65 pubmed publisher
    ..This study strengthens the emerging notion that PDZ domains can act as regulators of enzyme activity and therefore are active players in the dynamic regulation of signaling pathways. ..
  11. Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, et al. Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2. Blood Cells Mol Dis. 2015;55:21-6 pubmed publisher
    ..Neither SB203580 (a p38alpha/p38beta inhibitor) nor BIRB796 (a p38gamma/p38delta inhibitor) affected IL-13 production, while TMB-8 (a calcium chelator) diminished IL-13 production...
  12. Ghorbel M, Zaïdi I, Ebel C, Hanin M. Differential regulation of the durum wheat MAPK phosphatase 1 by calmodulin, bivalent cations and possibly mitogen activated protein kinase 3. Plant Physiol Biochem. 2018;135:242-252 pubmed publisher
    ..Our data are in favor of complex differential regulation of TMKP1 by its MPK substrates, metallic cations that might help in fine-tuning the plant cellular responses to various stresses. ..
  13. del Reino P, Alsina Beauchamp D, Escós A, Cerezo Guisado M, Risco A, Aparicio N, et al. Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer. Cancer Res. 2014;74:6150-60 pubmed publisher
    ..The related p38αMAPK (MAPK14) proteins p38γ (MAPK12) and p38δ (MAPK13) were recently shown to modulate the immune response, although their role in tumorigenesis ..
  14. Perdigão Henriques R, Petrocca F, Altschuler G, Thomas M, Le M, Tan S, et al. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. Oncogene. 2016;35:158-72 pubmed publisher
    ..targets of miR-200c (Crtap, Fhod1, Smad2, Map3k1, Tob1, Ywhag/14-3-3γ, Ywhab/14-3-3β, Smad5, Zfp36, Xbp1, Mapk12, Snail1) were experimentally validated by identifying their 3'UTR miR-200 recognition elements...
  15. Siddappa D, Beaulieu Ã, Gévry N, Roux P, Bordignon V, Duggavathi R. Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice. PLoS ONE. 2015;10:e0119387 pubmed publisher
    ..We conclude that Mapk3/1 regulates ovulation, at least in part, through Egr1 and its target gene, Ptgs2 in granulosa cells of ovulating follicles in mice. ..
  16. Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon M, Tiedje C, et al. Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK. PLoS ONE. 2015;10:e0136138 pubmed publisher
    ..p38-regulated and -activated kinase) are alternative names for a serine/threonine protein kinase downstream to ERK3/4 and p38 MAPK...
  17. Nawaito S, Dingar D, Sahadevan P, Hussein B, Sahmi F, Shi Y, et al. MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart. Am J Physiol Heart Circ Physiol. 2017;313:H46-H58 pubmed publisher
    ..protein kinase-5 (MK5) is a protein serine/threonine kinase that is activated by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The physiological function(s) of MK5 remains unknown...
  18. Elkhadragy L, Alsaran H, Morel M, Long W. Activation loop phosphorylation of ERK3 is important for its kinase activity and ability to promote lung cancer cell invasiveness. J Biol Chem. 2018;293:16193-16205 pubmed publisher
    b>ERK3 is an atypical mitogen-activated protein kinase (MAPK) that has recently gained interest for its role in promoting cancer cell migration and invasion...
  19. Kwon E, Choi M. Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice. Nutrients. 2018;10: pubmed publisher
    ..A positive relationship was detected between gene expressions of Tlr5, Map2k7, Mapk12, Mapk13, and Mapk9 and lipogenesis in epididymal white adipose tissue (eWAT) of luteolin-treated ..
  20. Kim Y, Kim D, Song S, Lee K, Yang B, Oh J, et al. Wee1B depletion promotes nuclear maturation of canine oocytes. Theriogenology. 2015;83:546-52 pubmed publisher
    ..These data suggest that Wee1B-siRNA microinjection could be a useful strategy to obtain mature canine oocytes for research and assisted canine reproduction. ..
  21. Zhang C, Gao J, Li M, Deng Y, Jiang C. p38? MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress. J Cell Sci. 2018;131: pubmed publisher
    ..Here, we report that proteasomal stress leads to the activation of p38 MAPK family members. Two of them, p38? (MAPK12) and p38? (MAPK13), are dispensable for micro-aggregate formation but are required for their targeting to the MTOC...
  22. Ou O, Huppi K, Chakka S, Gehlhaus K, DuBois W, Patel J, et al. Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity. Cancer Lett. 2014;354:336-47 pubmed publisher
    ..in combination with rapamycin in multiple breast cancer cell lines identified six genes, AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 that when silenced, each enhanced the sensitivity of multiple breast cancer lines to rapamycin...
  23. Blaha M, Nemcova L, Prochazka R. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. Reprod Biol Endocrinol. 2015;13:1 pubmed publisher
    ..05). The findings of this study indicate that high cGMP concentrations inhibit the maturation of pig oocytes in vitro but the inhibitory mechanism does not involve the suppression of MAPK3/1 activation in cumulus cells. ..
  24. Takahashi C, Miyatake K, Kusakabe M, Nishida E. The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture. J Biol Chem. 2018;293:8342-8361 pubmed publisher
    ..knockout and knockdown techniques along with gene profiling, we show that extracellular signal-regulated kinase 3 (ERK3), a poorly characterized atypical mitogen-activated protein kinase (MAPK), regulates the epithelial architecture in ..
  25. Lei Y, Wang W, Mei J, Wang C. Mitogen-activated protein kinase signal transduction in solid tumors. Asian Pac J Cancer Prev. 2014;15:8539-48 pubmed
    ..set of sequential actions: ERK(ERK1/ ERK2), c-Jun N(JNK/SAPK), p38 MAPK(p38α, p38β, p38γ and p38δ), and ERK3/ ERK4/ ERK5...
  26. Zheng J, Wen Y, Song Y, Wang K, Chen D, Magness R. Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod. 2008;78:143-50 pubmed
  27. Kukkonen Macchi A, Sicora O, Kaczynska K, Oetken Lindholm C, Pouwels J, Laine L, et al. Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death. J Cell Sci. 2011;124:216-27 pubmed publisher
    ..Our data suggest a link between mitotic regulation and the p38 MAPK pathway, in which p38? prevents chromosomal instability and supports mitotic cell viability. ..
  28. Perander M, Al Mahdi R, Jensen T, Nunn J, Kildalsen H, Johansen B, et al. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2. Sci Rep. 2017;7:43471 pubmed publisher
    The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G...
  29. Bian K, Muppani N, Elkhadragy L, Wang W, Zhang C, Chen T, et al. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells. Oncotarget. 2016;7:6665-75 pubmed publisher
    ..In the current study, we have found that ERK3, an atypical MAPK, phosphorylates TDP2 at S60 and regulates TDP2's phosphodiesterase activity, thereby ..
  30. Perander M, Keyse S, Seternes O. New insights into the activation, interaction partners and possible functions of MK5/PRAK. Front Biosci (Landmark Ed). 2016;21:374-84 pubmed
    ..However, since the discovery that MK5 is a bona fide interaction partner of the atypical MAP kinases ERK3 and ERK4 and that this interaction leads to both the activation and subcellular relocalisation of MK5, there has ..
  31. Chang N, Sincennes M, Chevalier F, Brun C, Lacaria M, Segalés J, et al. The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment. Cell Stem Cell. 2018;22:755-768.e6 pubmed publisher
    ..Here, we found that Carm1 is a specific substrate of p38γ/MAPK12 and that phosphorylation of Carm1 prevents its nuclear translocation...
  32. Moïse N, Dingar D, Mamarbachi A, Villeneuve L, Farhat N, Gaestel M, et al. Characterization of a novel MK3 splice variant from murine ventricular myocardium. Cell Signal. 2010;22:1502-12 pubmed publisher
    ..In vitro, GST-MK3.1 was strongly phosphorylated by p38alpha and p38beta, but a poor substrate for p38delta and p38gamma. GST-MK3.2 was poorly phosphorylated by p38alpha and p38beta and not phosphorylated by p38delta and p38gamma...
  33. Rodriguez J, Pilkington R, Garcia Munoz A, Nguyen L, Rauch N, Kennedy S, et al. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Cell Rep. 2016;14:2745-60 pubmed publisher
    ..We confirm that two proteins identified in our screen, MAPK6 (Erk3) and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism...
  34. Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Zhang G, et al. URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease. J Neuroinflammation. 2018;15:137 pubmed publisher
    ..This is buttressed by removal of pathologic Aβ species and restoration of the brain's microenvironment during disease. ..
  35. Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, et al. Phosphorylation and stabilization of topoisomerase II? protein by p38? mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011;286:35883-90 pubmed publisher
    ..These results reveal a new paradigm in which p38? actively regulates the drug-Topo II? signal transduction, and this may be exploited to increase the therapeutic activity of Topo II drugs. ..
  36. Hawkes W, Alkan Z. Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway. J Biol Chem. 2012;287:27371-9 pubmed publisher
    ..These results imply that SEPW1 silencing increases MKK4, which activates p38?, p38?, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest. ..
  37. Yang L, Wei Q, Li W, Xi Q, Zhao X, Ma B. NPR2 is involved in FSH-mediated mouse oocyte meiotic resumption. J Ovarian Res. 2016;9:6 pubmed publisher
    ..NPR2 is involved in FSH-mediated oocyte meiotic resumption, and this process is associated with the EGFR and MAPK3/1 signaling pathways. ..
  38. Xu B, Washington A, Hinton B. Initial Segment Differentiation Begins During a Critical Window and Is Dependent upon Lumicrine Factors and SRC Proto-Oncogene (SRC) in the Mouse. Biol Reprod. 2016;95:15 pubmed publisher
    ..Therefore, lumicrine factor-dependent SRC activity signaling through MAPK3/1 is important for the initiation of initial segment differentiation during a critical window of development. ..
  39. Mathien S, Déléris P, Soulez M, Voisin L, Meloche S. Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity. Mol Cell Biol. 2017;37: pubmed publisher
    Extracellular signal-regulated kinase 3 (ERK3) is an atypical mitogen-activated protein kinase (MAPK) whose regulatory mechanisms and biological functions remain superficially understood...
  40. Jacque J, Mann A, Enslen H, Sharova N, Brichacek B, Davis R, et al. Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase. EMBO J. 1998;17:2607-18 pubmed
    ..These studies demonstrate regulation of an early step in HIV-1 infection by the host cell MAPK signal transduction pathway. ..
  41. Klahan S, Huang C, Chien S, Wu M, Wong H, Huang C, et al. Bioinformatic analyses revealed underlying biological functions correlated with oxaliplatin responsiveness. Tumour Biol. 2016;37:583-90 pubmed publisher
    ..These genes and pathways might be potential targets for improving oxaliplatin treatment in colon cancer patients. ..
  42. Stone M, Sharma A, Mas V, Gehrau R, Mulloy D, Zhao Y, et al. Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. Transplantation. 2015;99:2494-503 pubmed publisher
    ..by EVLP + ATL1223 including the downregulation of genes involved in IL-1 signaling, such as ADCY9, ECSIT, IRAK1, MAPK12, and TOLLIP...
  43. Pew B, Harris R, Sbrana E, Guaman M, Shope C, Chen R, et al. Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress. Am J Obstet Gynecol. 2016;215:384.e1-384.e89 pubmed publisher
    ..We previously have shown that genetic deletion of Erk3 in mice results in growth restriction, cyanosis, and early neonatal lethality because of pulmonary immaturity and ..
  44. Khan R, Siddiqui N, Ul Haq A, Rahman M. Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker. Tumour Biol. 2016;37:715-21 pubmed publisher
    ..HSPB27 is a promising diagnostic marker for liver cancer although further large-scale studies are required. Also, molecular profiling may help pave the road to the discovery of new therapies. ..
  45. Robinson M, Xu Be B, Stippec S, Cobb M. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. J Biol Chem. 2002;277:5094-100 pubmed
    Extracellular signal-regulated kinase 3 (ERK3) is a member of the mitogen-activated protein (MAP) kinase family. ERK3 is most similar in its kinase catalytic domain to ERK2, yet it displays many unique properties...
  46. Umasuthan N, Bathige S, Noh J, Lee J. Gene structure, molecular characterization and transcriptional expression of two p38 isoforms (MAPK11 and MAPK14) from rock bream (Oplegnathus fasciatus). Fish Shellfish Immunol. 2015;47:331-43 pubmed publisher
    ..The p38 subfamily that includes four members namely p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13), regulates the activation of several transcription factors...
  47. Ramachandra C, Mehta A, Wong P, Shim W. ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells. Stem Cells. 2016;34:288-98 pubmed publisher
    ..This study reveals a novel pathway that directly links ErbB4 and p38γ to the transcriptional machinery of NKx2.5-GATA4 complex which is critical for cardiomyocyte formation during mammalian heart development. ..
  48. Li Q, He M, Mao L, Wang X, Jiang Y, Li M, et al. Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells. Cell Physiol Biochem. 2017;41:2016-2026 pubmed publisher
    ..These findings indicate that the repression of NNMT may underlie nickel-induced H3K9 dimethylation by altering the cellular SAM/SAH ratio. ..
  49. Ling S, Xie H, Yang F, Shan Q, Dai H, Zhuo J, et al. Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1. J Hematol Oncol. 2017;10:59 pubmed publisher
    ..Seventy-three tumor samples from ICC patients were used to detect the expression of ERK3 by immunohistochemistry...
  50. Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, et al. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim Biophys Acta. 1998;1380:177-82 pubmed
    ..Triplicated transfection resulted in phosphorylation of tau at 8 observed sites (Ser-199, Ser-202, Thr-205, Thr-231, Ser-235, Ser-396, Ser-404, and Ser-413). ..
  51. Gutierrez Sanmartin D, Varela Ledo E, Aguilera A, Romero Yuste S, Romero Jung P, Gomez Tato A, et al. Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I. J Gen Virol. 2008;89:1661-71 pubmed publisher
    ..the individual implication of the p38 mitogen-activated protein kinase (MAPK) isoforms (p38alpha, p38beta, p38gamma and p38delta) during apoptosis induced by HIV-1, taking into account that HIV-1 replication is known to be ..
  52. Martinez Noel G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan J, et al. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018;430:1024-1050 pubmed publisher
    ..Previously, we showed that UBE3A associates with HERC2, NEURL4, and MAPK6/ERK3 in a high-molecular-weight complex of unknown function that we refer to as the HUN complex (HERC2, UBE3A, and ..
  53. Ruiz Esparza Garrido R, Torres Márquez M, Viedma Rodríguez R, Velázquez Wong A, Salamanca Gómez F, Rosas Vargas H, et al. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy. Tumour Biol. 2016;37:6749-59 pubmed publisher
    ..Altogether, our results indicate-for the first time-that BIK controls the expression of miRNAs, as well as the autophagic flux in MDA-MB-231 cells. ..
  54. Dwyer S, Gelman I. Cross-Phosphorylation and Interaction between Src/FAK and MAPKAP5/PRAK in Early Focal Adhesions Controls Cell Motility. J Cancer Biol Res. 2014;2: pubmed
    P38-regulated and activated kinase (PRAK/MAPKAPK5) is a serine/threonine kinase which lies downstream of the p38 and ERK3/4 MAP kinase pathways...
  55. Goedert M, Cohen E, Jakes R, Cohen P. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]. FEBS Lett. 1992;312:95-9 pubmed
    ..Of the major serine/threonine protein phosphatases found in mammalian tissues only protein phosphatase 2A (PP2A) could dephosphorylate tau phosphorylated in this manner, with PP2A1 being the most effective form of the enzyme. ..
  56. Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, et al. p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. Stem Cells. 2015;33:2738-47 pubmed publisher
    ..p38γ mitogen-activated protein kinase (MAPK) (gene name: MAPK12) is overexpressed in TNBC but how overexpressed p38γ contributes to TNBC remains unknown...
  57. Zhang D, Li Y, Wang R, Li Y, Shi P, Kan Z, et al. Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..migration inhibition demonstrated that CCND1 and CCNE1 were reduced; CDK5R1, BBC3, EGR1, SLC25A4, PDCD7, MAPK11, MAPK12, FADD and DAXX were enhanced, among which BBC3 and DAXX were direct targets of REST, as verified by ChIP (..
  58. Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D. Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription. J Biol Chem. 2007;282:91-9 pubmed
    ..We further produced mutants of the other p38 isoforms and found that p38beta(D176A), p38gamma(D179A), p38delta(D176A), and p38delta(F324S) are spontaneously active in vivo...
  59. Browne A, Göbel A, Thiele S, Hofbauer L, Rauner M, Rachner T. p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells. Cell Death Dis. 2016;7:e2119 pubmed publisher
    ..by targeting individual p38 MAPK isoforms with siRNA revealed a stronger role for MAPK11 than MAPK14 and MAPK12 in the regulation of DKK-1...
  60. Hanger D, Betts J, Loviny T, Blackstock W, Anderton B. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem. 1998;71:2465-76 pubmed
    ..We identified 22 phosphorylation sites in PHF-tau, including five sites not previously identified. The combination of our new data with previous reports shows that PHF-tau can be phosphorylated on at least 25 different sites. ..
  61. Morishima Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, et al. Hyperphosphorylation of tau in PHF. Neurobiol Aging. 1995;16:365-71; discussion 371-80 pubmed
    ..This extraphosphorylation may provide PHF-tau with the unusual characteristics including assembly incompetence. ..
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