MAPK11

Summary

Gene Symbol: MAPK11
Description: mitogen-activated protein kinase 11
Alias: P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, MAP kinase 11, MAP kinase p38 beta, MAPK 11, mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, stress-activated protein kinase 2, stress-activated protein kinase 2b, stress-activated protein kinase-2, stress-activated protein kinase-2b
Species: human

Top Publications

  1. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
  2. ncbi Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization
    Niina Reunanen
    Centre for Biotechnology and Department of Medicinal Biochemistry, University of Turku, FIN 20520 Turku, Finland
    J Biol Chem 277:32360-8. 2002
  3. ncbi Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
    P A Eyers
    Department of Biochemistry, University of Dundee, UK
    Chem Biol 5:321-8. 1998
  4. ncbi The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
    W M Macfarlane
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 272:20936-44. 1997
  5. pmc Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada
    Mol Biol Cell 14:1418-32. 2003
  6. pmc Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428
    Mercedes Pozuelo Rubio
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 392:163-72. 2005
  7. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
  8. ncbi Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    Dorota Gabrys
    Department of Radiation Oncology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
    Int J Radiat Oncol Biol Phys 69:1553-62. 2007
  9. ncbi SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)
    S Lawler
    Department of Biochemistry, University of Dundee, UK
    FEBS Lett 414:153-8. 1997
  10. ncbi Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 409:57-62. 1997

Detail Information

Publications149 found, 100 shown here

  1. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  2. ncbi Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization
    Niina Reunanen
    Centre for Biotechnology and Department of Medicinal Biochemistry, University of Turku, FIN 20520 Turku, Finland
    J Biol Chem 277:32360-8. 2002
    ..It is conceivable that both modes of action play an important role in controlling the proteolytic phenotype of fibroblasts, e.g. in wound repair and tumor invasion...
  3. ncbi Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
    P A Eyers
    Department of Biochemistry, University of Dundee, UK
    Chem Biol 5:321-8. 1998
    ..belongs to a class of pyridinyl imidazoles that inhibits the stress-activated protein (SAP) kinases SAPK2a/p38 and SAPK2b/p38 beta 2 but not other mitogen-activated protein kinase family members...
  4. ncbi The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
    W M Macfarlane
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 272:20936-44. 1997
    ..gene transcription were both prevented by SB 203580, a specific inhibitor of stress-activated protein kinase 2 (SAPK2, also termed p38 mitogen-activated protein kinase, reactivating kinase, CSBP, and Mxi2) but not by several other ..
  5. pmc Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada
    Mol Biol Cell 14:1418-32. 2003
    ....
  6. pmc Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428
    Mercedes Pozuelo Rubio
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 392:163-72. 2005
    ..While p42/p44 MAPK (mitogen-activated protein kinase), SAPK2 (stress-activated protein kinase 2)/p38 and PKC (protein kinase C) were all activated by PMA in HeLa cells, the ..
  7. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
    Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2)..
  8. ncbi Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    Dorota Gabrys
    Department of Radiation Oncology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
    Int J Radiat Oncol Biol Phys 69:1553-62. 2007
    ..To investigate the effects of radiation on the endothelial cytoskeleton and endothelial monolayer permeability and to evaluate associated signaling pathways, which could reveal potential mechanisms of known vascular effects of radiation...
  9. ncbi SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)
    S Lawler
    Department of Biochemistry, University of Dundee, UK
    FEBS Lett 414:153-8. 1997
    ..SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38beta, SAPK3/ERK6 or SAPK4. It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila...
  10. ncbi Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 409:57-62. 1997
    ..kinases SAPK1gamma (also called JNK1), SAPK2a (also called p38, RK, CSBPs, Mpk2 and Mxi2), SAPK2b (also called p38beta), SAPK3 (also called ERK6 and p38gamma) and SAPK4 phosphorylate tau at many serine/threonine-prolines, as ..
  11. doi Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes
    Qinxi Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 283:11014-23. 2008
    p38alpha and p38beta MAPKs (mitogen-activated protein kinases) share about 80% of their protein sequence identity, but have quite different biological functions...
  12. ncbi Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics
    L H Cohen
    Gaubius Laboratory, TNO Prevention and Health, Leiden University, Leiden, The Netherlands
    Biochem Pharmacol 60:1061-8. 2000
    ..Their current and possible future application as therapeutics in cancer, restenosis, angiogenesis, and osteoporosis is briefly discussed...
  13. pmc Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
    Kevin M Rice
    Department of Pharmacology, Physiology and Toxicology, Joan C, Edwards School of Medicine, Marshall University, Huntington, WV, USA
    Cardiovasc Diabetol 5:18. 2006
    ..On the basis of these findings, we hypothesized that diabetes may be associated with alterations in how veins "sense" and "respond" to altered mechanical loading...
  14. ncbi Activation of p38 mitogen-activated protein kinases by endothelin and noradrenaline in small arteries, regulation by calcium influx and tyrosine kinases, and their role in contraction
    J Ohanian
    Department of Medicine, University of Manchester, Manchester Royal Infirmary, Manchester, UK
    Arterioscler Thromb Vasc Biol 21:1921-7. 2001
    ..Both vasoconstrictors activated p38alpha and/or p38beta but not p38gamma or p38delta, leading to increased HSP kinase activity...
  15. ncbi Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells
    P Negre-Aminou
    TNO Prevention and Health, Gaubius Laboratory, Zernikedreef 9, 2301 CE, Leiden, The Netherlands
    Biochem Pharmacol 61:991-8. 2001
    ..PDGF)-induced DNA synthesis, extracellular-regulated kinase 1/2 (ERK1/2), p38/stress-activated protein kinase 2 (SAPK2), RhoA and Rac1 activation...
  16. ncbi Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4
    Julie Laferriere
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, Canada G1R2J6
    Clin Exp Metastasis 21:257-64. 2004
    ..This interaction activates, in the cancer cells, the MAPK SAPK2/p38, which leads to their transendothelial migration (Laferrière et al., J Biol Chem 2001; 276: 33762)...
  17. pmc Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 380:19-30. 2004
    ..It is not blocked by SB 203580, which inhibits SAPK2a/p38alpha and SAPK2b/p38beta but not SAPK3/p38gamma, or by the ERK pathway inhibitor PD 184352...
  18. pmc Nogo-B is a new physiological substrate for MAPKAP-K2
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 391:433-40. 2005
    ..phosphorylation is prevented by SB 203580, an inhibitor of SAPK2a (stress-activated protein kinase 2a)/p38a and SAPK2b/p38b, and does not occur in embryonic fibroblasts generated from SAPK2a/p38a-deficient mice...
  19. ncbi The role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages
    Concetta Crisafulli
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, Messina, Italy
    Shock 32:62-73. 2009
    ..In conclusion, our study demonstrates that the endogenous and exogenous PPAR-alpha ligands reduce the degree of macrophage inflammation caused by LPS/IFN-gamma stimulation...
  20. ncbi The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    Chryso Kanthou
    Tumour Microcirculation Group, Gray Cancer Institute, Mount Vernon Hospital, PO Box 100, Northwood, Middlesex HA6 2JR, UK
    Blood 99:2060-9. 2002
    ....
  21. ncbi SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    S Mertens
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 383:273-6. 1996
    ..Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle...
  22. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
    ..This phosphorylation is dependent on the kinase p38/SAPK2 and correlates with the activation of MAPKAP kinase 2 (MK2)...
  23. pmc Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
    A Cuenda
    Department of Biochemistry, University of Dundee, UK
    EMBO J 16:295-305. 1997
    ..stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF) in a similar manner to SAPK1 (also termed JNK) and SAPK2 (also termed p38, RK, CSBP and Mxi2)...
  24. ncbi Intrinsically active variants of all human p38 isoforms
    Michal Avitzour
    Department of Biological Chemistry, The Wolfson Centre for Applied Structural Biology, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    FEBS J 274:963-75. 2007
    ..The four mammalian isoforms (p38alpha, p38beta, p38gamma, and p38delta) are coexpressed and coactivated in the same cells...
  25. ncbi Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly
    P F T Cezar-de-Mello
    Departamento de Farmacologia e Psicobiologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Oncogene 25:122-9. 2006
    ..A concomitant impairment in stress-activated protein kinase (SAPK2/p38) phosphorylation suggests that ATL inhibition of VEGF-stimulated actin polymerization involves the SAPK2/p38 ..
  26. ncbi Stress-induced glucose uptake in bovine chromaffin cells: a comparison of the effect of arsenite and anisomycin
    C Fladeby
    Department of Physiology, University of Bergen, Arstadveien 19, 5009, Bergen, Norway
    Biochim Biophys Acta 1452:313-21. 1999
    ..The selective inhibitor of stress-activated protein kinase 2 (SAPK2), SB 203580, inhibited completely anisomycin-induced glucose uptake but only partly suppressed uptake stimulated ..
  27. ncbi Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
    A Cuenda
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 274:4341-6. 1999
    ..accompanied by a strong activation of p70 S6 kinase and the mitogen-activated protein kinase (MAPK) family member SAPK2/p38, without significant activation of p42 MAPK and only slight activation of SAPK1/JNK and protein kinase Balpha...
  28. ncbi Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts
    Wissam H Faour
    Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:9536-46. 2005
    ..Initial studies confirmed that PGE2 induces egr-1 mRNA expression and protein synthesis by restricted SAPK2/p38 MAPK-dependent activating transcription factor-2 (ATF-2) dimer transactivation of the egr-1 promoter as judged ..
  29. ncbi Paradoxical activation of Raf by a novel Raf inhibitor
    C A Hall-Jackson
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, The University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Chem Biol 6:559-68. 1999
    ..Raf is a proto-oncogene that is activated in response to growth factors or phorbol esters, and is thought to activate MAP kinase kinase-1 (MKK1) and hence the classical MAP kinase (MAPK) cascade...
  30. ncbi The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells
    Ariel Quinones
    Department of General Surgery, ECHO Laboratory, Martin Luther University, D 06097, Halle, Germany
    Life Sci 72:2975-92. 2003
    ..treatment with the MAP kinase (MAPK) inhibitor SB203580, which specifically blocks the stress inducible p38/SAPK2 pathway, did not alter egr-1 induction...
  31. ncbi PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation
    Dominique Sawka-Verhelle
    Departments of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 279:17772-84. 2004
    ..differentiation and phosphorylation of CREB-1 and the related factor CREM-1 are stimulated by M-CSF in a SAPK2/p38-dependent manner...
  32. ncbi Dual enzyme-linked immunosorbent assay system for detection of endogenous kinase activities of mitogen- and stress-activated protein kinase-1/2
    Tsuyoshi Ishii
    GlaxoSmithKline K K, Tsukuba shi, Ibaraki, Japan
    Assay Drug Dev Technol 5:523-33. 2007
    ..Our established system is applicable to inhibitor screening and drug discovery related to MSK1/MSK2...
  33. pmc Determinants that control the specific interactions between TAB1 and p38alpha
    Huamin Zhou
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, China
    Mol Cell Biol 26:3824-34. 2006
    ..Furthermore, chimeric analysis with p38beta (which does not bind to TAB1) revealed a previously unidentified locus of p38alpha comprising Thr218 and Ile275 ..
  34. ncbi Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway
    K Merienne
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France
    Oncogene 19:4221-9. 2000
    ..and activation of RSK2 is mediated by the MAPK/ERK pathway, but that the Stress-Activated Protein Kinase 2 (SAPK2)/p38 pathway is also involved...
  35. ncbi Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
    Laurent Lamalice
    Centre de recherche en cancérologie de l Université Laval, 9 rue McMahon, Quebec G1R 2J6, Canada
    J Biol Chem 281:34009-20. 2006
    ..that following VEGF treatment of endothelial cells, VEGFR-2 is phosphorylated on Tyr1214 upstream of the Cdc42-SAPK2/p38-MAPKAP K2 pathway...
  36. ncbi p38beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis
    Y L Guo
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 82:556-65. 2001
    ..Using adenovirus-mediated gene transfer technique, we further demonstrated that p38beta, but not p38alpha, is essential to protect the cells from TNF-alpha toxicity...
  37. ncbi Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression
    Mohiuddin M Taher
    Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA
    Mol Cell Biochem 254:289-97. 2003
    ..We conclude that the mechanism by which curcumin modulates UV activation of HIV-LTR gene expression mainly involves the inhibition of NF-kappaB activation...
  38. ncbi Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages
    Catherine Ropert
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Brazil
    J Immunol 171:1456-65. 2003
    ..These results indicate a critical role of p38/stress-activated protein kinase-2 and NF-kappaB-dependent phosphatase in macrophage hyporesponsiveness induced by microbial products that activate TLR2 and TLR4...
  39. ncbi Role of mitogen- and stress-activated kinases in ischemic injury
    Elaine A Irving
    Neurology CEDD, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK
    J Cereb Blood Flow Metab 22:631-47. 2002
    ..are those that use the extracellular signal-regulated kinase (ERK1/2) or the stress-activated protein kinase (p38/SAPK2 or JNK/SAPK) pathways...
  40. ncbi Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes
    S M Davidson
    Departement de Biologie, Unité de Génétique Moléculaire, Ecole Normale Superieure, 46 rue d Ulm, Paris Cedex 05, 75230, France
    Dev Biol 218:146-60. 2000
    ..The phosphorylation of HSP25 by the p38/SAPK2 pathway is known to be important for certain of its functions...
  41. ncbi Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells
    Thomas P Kenny
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:255-63. 2004
    ..and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2. These inhibitory effects were observed when HAECs were treated with the flavonol fraction (molecular weight 280 ..
  42. ncbi Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity
    C N Antonescu
    Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Endocrinology 146:3773-81. 2005
    ..This observation suggested that insulin may increase GLUT4 activity via p38alpha and/or p38beta. Here we further explore the possible participation of p38MAPK through a combination of molecular strategies...
  43. ncbi STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
    U Holtick
    Universitat zu Koln, Klinik fur Innere Medizin I, Koln, Germany
    Leukemia 19:936-44. 2005
    ..AG17 treatment was accompanied by decreased levels of STAT3 phosphorylation, whereas NF-kappaB and p38/SAPK2 signaling were not inhibited...
  44. ncbi 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice
    M Vilatoba
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Transplant Proc 37:399-403. 2005
    ..JNK and p38alpha activation have been associated with apoptosis; p38beta with cell survival; and ERK with proliferation...
  45. ncbi Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways
    Guohu Li
    Center for Perinatal Biology, Department of Pharmacology and Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Pharmacol Exp Ther 312:112-9. 2005
    ..In contrast, the p38beta MAPK and mitogen-activated protein kinase kinase/ERK inhibitors SB 202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-..
  46. pmc Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy
    Kojo S J Elenitoba-Johnson
    Department of Pathology, Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 100:7259-64. 2003
    ..Notably, growth factor cytokine receptors and p38beta-mitogen-activated protein kinase (MAPK) were differentially expressed in the DLBCLs...
  47. ncbi T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3'-untranslated region of COX-2 mRNA
    Wissam H Faour
    Molecular Biology Program, University of Montreal, Quebec, Canada
    J Biol Chem 278:26897-907. 2003
    ..This response was mediated entirely by the stress-activated protein kinase 2/p38 cascade. As such, IL-17 can exert direct transcriptional and post-transcriptional control over target proinflammatory cytokines and oncogenes...
  48. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation...
  49. pmc Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase
    Premanand C Sundivakkam
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612 7343, USA
    J Biol Chem 288:17030-41. 2013
    ..Thus, our findings demonstrate that SOCE activates CaMKKβ-AMPKα1-p38β MAPK signaling to phosphorylate STIM1, thereby suppressing endothelial SOCE and permeability responses...
  50. pmc Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells
    Takahiko Kogai
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 287:3292-300. 2012
    ..Targeting isoform-selective activation of p38 may enhance NIS induction, resulting in higher efficacy of (131)I concentration and treatment of breast cancer...
  51. pmc Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
    Hong Pyo Kim
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 102:11319-24. 2005
    ..b>p38beta-/- fibroblasts did not induce caveolin-1 in response to CO, and exhibited a diminished basal caveolin-1 ..
  52. pmc SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells
    Zhe Wang
    Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e31809. 2012
    ..Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact...
  53. pmc Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB
    Ye Tian
    Department of Orthopaedic Surgery and the Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Pathol 182:2310-21. 2013
    ..To our knowledge, this is the first study to show nonredundant contribution of both ADAMTS-4 and ADAMTS-5 to aggrecan degradation in human NP cells in vitro...
  54. pmc Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
    Shahab Uddin
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:147-52. 2004
    p38alpha, p38beta, p38gamma, and p38delta are four isoforms of p38 mitogen-activated protein (MAP) kinase (MAPK) involved in multiple cellular functions such as cell proliferation, differentiation, apoptosis, and inflammation response...
  55. ncbi Mitogen-activated protein kinases are in vivo transducers of osmosensory signals in fish gill cells
    D Kultz
    The Whitney Laboratory, University of Florida, 9505 Ocean Shore Boulevard, 32080, St Augustine, FL, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:821-9. 2001
    ..stress-activated protein kinase 1/ Jun N-terminal kinase (SAPK1), and stress-activated protein kinase 2/ p38 (SAPK2), were measured in gill epithelium of the euryhaline teleost Fundulus heteroclitus exposed for 1 h to 4 weeks to ..
  56. ncbi Soluble fractalkine prevents monocyte chemoattractant protein-1-induced monocyte migration via inhibition of stress-activated protein kinase 2/p38 and matrix metalloproteinase activities
    Sebastien Vitale
    Institut National de la Sante et de la Recherche Medicale, Unité 364, Institut Federatif de Recherche 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    J Immunol 172:585-92. 2004
    ..In this study, we found that stress-activated protein kinase (SAPK)1/c-Jun N-terminal kinase 1 and SAPK2/p38 are involved in the control of MCP-1-induced MonoMac6 cell migration...
  57. pmc Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes
    Hideya Mizuno
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:1-9. 2006
    ..These results suggest that extracellular-signal regulated kinase (ERK), JNK, or p38 are implicated in EGF-induced neoplastic transformation of human cells...
  58. pmc Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster
    Jeerang Wongtrakul
    Research Institute for Health Sciences, Chiang Mai University, POBOX 80 CMU, Chiang Mai, Thailand 50200
    J Insect Sci 12:107. 2012
    ..The p38b mitogen-activated protein kinase is involved in cellular stress response...
  59. ncbi Dysregulation of the endothelial cellular response to oxidative stress in cancer
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, Quebec, Canada
    Mol Carcinog 45:362-7. 2006
    ..activation of the extracellular-signal regulated kinase (ERK) and the stress-activated protein kinase-2/p38 (SAPK2/p38) pathways...
  60. ncbi Activation of p38 MAPK suppresses matrix metalloproteinase-1 gene expression induced by platelet-derived growth factor
    Hideharu Endo
    Department of Clinical Biology of Extracellular Matrix F7, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Japan
    Arch Dermatol Res 294:552-8. 2003
    ..Overexpression of p38beta2, but not of p38alpha, significantly decreased PDGF-BB-induced MMP-1 promoter activity, although PDGF-BB activated ..
  61. ncbi EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    H M Rosenfeldt
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, D C 20007, USA
    FASEB J 15:2649-59. 2001
    ..These results may also shed light on the vital role of EDG-1 in vascular maturation...
  62. doi MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation
    T Lin
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    Toxicology 247:145-53. 2008
    ..Similar results were obtained with siRNA against two isoforms of p38 MAPK, p38alpha and p38beta. Wortmannin, selective inhibitor of DNA-PK and ATM/ATR, abolished p53 phosphorylation, indicating an involvement ..
  63. pmc Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase
    Eriko Ohnishi
    Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 30:675-83. 2010
    ..In Xenopus laevis embryos, depletion of either p38beta or NLK by antisense morpholino oligonucleotides results in a severe defect in anterior development and impaired ..
  64. ncbi Signalling pathways in cardiac myocyte hypertrophy
    P H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Ann Med 33:611-22. 2001
    ..signal-regulated kinase (ERK) cascade, the c-Jun N-terminal kinase (JNK or SAPK1) cascade, and the p38-MAPK (SAPK2-5) cascade...
  65. ncbi Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood
    Hadar Arien-Zakay
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Mol Neurosci 32:179-91. 2007
    ..of the mitogen-activated protein kinases ERK2 (36-fold vs control), p38alpha (nine-fold vs control) and p38beta (23-fold vs control), most likely related to survival and/or differentiation...
  66. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38...
  67. ncbi Tumor cell differentiation by butyrate and environmental stress
    O Witt
    Children s Hospital, University of Gottingen, Robert Koch Street 40, D 37075 Gottingen, Germany
    Cancer Lett 171:173-82. 2001
    ..Stress signaling pathways might be an interesting pharmacologic target for differentiation therapy of malignant disease...
  68. pmc Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    H Enslen
    Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO J 19:1301-11. 2000
    The p38 mitogen-activated protein kinase (MAPK) group is represented by four isoforms in mammals (p38alpha, p38beta2, p38gamma and p38delta)...
  69. ncbi Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis
    Anne T Funding
    Department of Dermatology, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    J Invest Dermatol 127:2012-9. 2007
    ..Our results indicate that the p38-MAPK/MSK1/MSK2 and CREB signalling pathway may play a role in the pathogenesis of psoriasis...
  70. ncbi Proximal events in signaling by plasma membrane estrogen receptors
    Mahnaz Razandi
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, California 90822, USA
    J Biol Chem 278:2701-12. 2003
    ..E2 also induced AKT up-regulation in MCF-7 cells and p38beta MAP kinase activity in endothelial cells, blocked by an MMP inhibitor, GM6001, and tyrphostin AG1478...
  71. ncbi Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells
    H T Nguyen
    The Urologic Laboratory, Department of Urology, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 279:C1155-67. 2000
    ..Inhibitors of the p38 SAPK2 pathway, the angiotensin receptor type 1 (AT1), and the ErbB2 tyrosine kinase reduced each of these activities, ..
  72. doi Extended kinase profile and properties of the protein kinase inhibitor nilotinib
    Paul W Manley
    Novartis Institutes for BioMedical Research, Basel, Switzerland
    Biochim Biophys Acta 1804:445-53. 2010
    ..In addition nilotinib has now been found to bind to both MAPK11 (p38beta) and MAPK12 (p38alpha), as well as with very high affinity to ZAK kinase...
  73. ncbi Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation
    Young Jun Kang
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:5075-82. 2008
    ..responses has been shown in a number of studies using chemical inhibitors, though the inhibitors also inhibit p38beta and perhaps some other enzymes...
  74. pmc Effect of p38 MAP kinases on contractility and ischemic injury in intact heart
    H R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Acta Physiol Hung 96:307-23. 2009
    ..mice with cardiac-specific expression of kinase dead (dominant negative) mutants of p38alpha (p38alphadn) or p38beta (p38betadn). Hearts were subjected to 20 min ischemia and 40 min reperfusion...
  75. doi Changes in the level of apoptosis-related proteins in Jurkat cells infected with HIV-1 versus HIV-2
    Xue Wang
    Labaratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Cell Biochem 337:175-83. 2010
    ..in cell signaling such as p47, p38alpha, JNK, c-Yes, total PKC, and decreased the expression of molecules such as p38beta, ERK1/2, and XIAP relative to HIV-2 infection...
  76. doi Functions of epidermal growth factor receptor in cisplatin response of thyroid cells
    Antonella Muscella
    Department of Biological and Environmental Sciences and Technologies Di S Te B A, Universita del Salento, via Prov le per Monteroni, 73100 Lecce, Italy
    Biochem Pharmacol 77:979-92. 2009
    ....
  77. ncbi E2F1 stability is regulated by a novel-PKC/p38beta MAP kinase signaling pathway during keratinocyte differentiation
    I A Ivanova
    Department of Physiology and Pharmacology, University of Western Ontario, London Ontario, Canada N6A 5C1
    Oncogene 25:430-7. 2006
    ..We also demonstrate that E2F1 downregulation by novel PKC isozymes requires activation of p38beta mitogen-activated protein kinase (MAPK)...
  78. doi Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression
    Fabio Carrozzino
    Dept of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Am J Physiol Cell Physiol 297:C775-87. 2009
    ..of p38alpha by isoform-specific small interfering RNAs increased claudin-4 and -8 mRNAs, whereas silencing of p38beta only increased claudin-4 mRNA...
  79. ncbi Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact
    Robert S Krauss
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 118:2355-62. 2005
    ..Mechanistic studies in vitro indicate that specific cadherins and immunoglobulin superfamily proteins exert some of their effects in an interdependent fashion by signaling from a multiprotein complex found at sites of cell-cell contact...
  80. pmc Generation and characterization of p38beta (MAPK11) gene-targeted mice
    Victoria A Beardmore
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
    Mol Cell Biol 25:10454-64. 2005
    ..primarily in response to inflammatory cytokines and cellular stress, and inhibitors which target the p38alpha and p38beta MAPKs have shown potential for the treatment of inflammatory disease...
  81. doi B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms
    Véronique Bouchard
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Apoptosis 13:531-42. 2008
    ..of Fak, Src, Akt-1 and Erk1/2, a loss of Fak-Src association, and a sustained/enhanced activation of p38beta, which is required as apoptosis/anoikis driver; (2) PI3-K/Akt-1 up-regulates the expression of Bcl-X(L) and Mcl-1,..
  82. ncbi PLD1 and ERK2 regulate cytosolic lipid droplet formation
    Linda Andersson
    Wallenberg Laboratory for Cardiovascular Research, Goteborg University, Sahlgrenska University Hospital, Sweden
    J Cell Sci 119:2246-57. 2006
    ..Similar manipulations of other Map kinases such as ERK1, JNK1 or JNK2 and p38alpha or p38beta were without effect...
  83. ncbi PRAK is essential for ras-induced senescence and tumor suppression
    Peiqing Sun
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 128:295-308. 2007
    ..Furthermore, we show that PRAK activates p53 by direct phosphorylation. We propose that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras-induced senescence and tumor suppression...
  84. ncbi Downregulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation
    Feiyue Xing
    Key Laboratory of Ministry of Education, Department of Biochemistry, College of Life Science and Technology, Jinan University, 601 Huangpu West Avenue, Guangzhou 510632, P R China
    Biochem Cell Biol 84:780-8. 2006
    ..The wild-types of p38alpha, p38beta, p38gamma, and p38delta signal molecules all markedly downregulated promoter activity, which could be reversed by ..
  85. doi HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2
    Ju Il Kang
    School of Life Sciences and Biotechnology, Korea University, Republic of Korea
    Biochem Biophys Res Commun 407:248-53. 2011
    ..These results suggest that, in addition to viral dsRNA, stress signaling contributes to the regulation of cellular antiviral response...
  86. ncbi [The cellular location and significance of p38alpha/beta isoforms in the lumbar spinal cord of the bone cancer pain rats]
    Hang Dong
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Zhonghua Yi Xue Za Zhi 87:53-7. 2007
    ..To examine the cellular distribution and location of p38alpha/beta isoforms in the lumbar spinal cord of the bone cancer pain rats...
  87. pmc Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma
    Cheri Cloninger
    Department of Research and Development, Greater Los Angeles VA Healthcare System, 16111 Plummer Street 151, Sepulveda, CA 91343, USA
    Mol Cancer Ther 10:2244-56. 2011
    ..The activation of this salvage pathway is dependent on SAPK2/p38-mediated activation of IRES-dependent initiation of the cyclin D1 and c-MYC mRNAs, resulting in the ..
  88. pmc MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress
    Gerhard Seisenbacher
    Institute of Molecular Systems Biology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    PLoS Genet 7:e1002168. 2011
    ..By performing a thorough genetic analysis, we demonstrate that a signalling complex consisting of p38b and MK2 forms a branch of SAPK signalling that is required in the larval hindgut to prevent stress-dependent damage ..
  89. ncbi Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection
    Eusebio Perdiguero
    Program on Differentiation and Cancer, Centre for Genomic Regulation, UPF PRBB, CIBER de Enfermedades Neurodegenerativas, Barcelona, Spain
    Cell Cycle 6:1298-303. 2007
    ..However, the relative contribution of the four p38 MAP kinases (p38alpha, p38beta, p38gamma and p38delta) to this process was unknown...
  90. doi Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
    Pinglong Xu
    Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 37:551-66. 2010
    ..Autocrine EGF receptor activation through TACE-mediated ectodomain shedding intimately links inflammation and cancer progression and may play a role in stress and conditions that relate to p38 MAP kinase activation...
  91. pmc Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression
    Bethany L Fitzsimmons
    Department of Anesthesiology, University of California San Diego, California, USA
    Neuroreport 21:313-7. 2010
    ..We investigated whether either the spinal isoform p38alpha or p38beta is involved in peripheral inflammation evoked pain state and increased expression of spinal COX-2...
  92. ncbi Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet
    Vanessa C Arantes
    Departamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiaba, MT, Brazil
    Br J Nutr 96:1006-12. 2006
    ..rats show high NEFA levels, we assessed PDX-1 and insulin mRNA expression, as well as PDX-1 and p38/stress activated protein kinase 2 (SAPK2) protein expression, in islets from young rats fed low (6%) or normal (17%; control) protein ..
  93. ncbi Inhibition of TRAIL-induced apoptosis by IL-8 is mediated by the p38-MAPK pathway in OVCAR3 cells
    T Abdollahi
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19106, USA
    Apoptosis 10:1383-93. 2005
    ..The present study further investigates involvement of the p38 MAPK pathway in IL-8's ability to block TRAIL-induced apoptosis in the ovarian surface epithelial cancer cell line, OVCAR3...
  94. ncbi Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O
    Matthias Husmann
    Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University, Mainz, Hochhaus am Augustusplatz, 55131 Mainz, Germany
    Biochem Biophys Res Commun 344:1128-34. 2006
    ..In contrast, blockade of p38 in SLO permeabilized cells did not affect the capacity of the cells to replenish their ATP stores...
  95. ncbi The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin
    C Johansen
    Department of Dermatology, Marselisborg Hospital, PP Orumsgade 11, University of Aarhus, DK 8000 Aarhus C, Denmark
    Br J Dermatol 152:37-42. 2005
    ..Major signalling pathways used by eukaryotic cells to transduce extracellular signals into cellular responses impinge on the mitogen-activated protein kinases (MAPKs)...
  96. ncbi A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability
    M Clauss
    Department of Molecular Cell Biology, Max Planck Institute, Bad Nauheim, Germany
    Blood 97:1321-9. 2001
    ....
  97. ncbi p38 Mitogen-activated protein kinases on the body surface--a function for p38 delta
    Richard L Eckert
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Invest Dermatol 120:823-8. 2003
    The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6)...
  98. ncbi Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase
    Argyrios K Stringaris
    Department of Neurology, University of Gottingen, 37075, Gottingen, Germany
    Neurobiol Dis 11:355-68. 2002
    ..Modulation of cell death pathways activated by pneumolysin may influence the outcome of pneumococcal meningitis...
  99. ncbi Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line
    Angel Garcia-Lora
    Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Avda de las Fuerzas Armadas 2, 18014 Granada, Spain
    Cancer Immunol Immunother 52:59-64. 2003
    ..In MAPK expression we found that unstimulated NKL cells have the following profile: ERK2>ERK6>p38gamma>p38beta>ERK1. ERK3, ERK3 rel, ERK5/ERK4 and p38delta were not expressed...
  100. ncbi Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta
    G A Keesler
    Amgen Inc, Boulder, Colorado, 80301, USA
    Protein Expr Purif 14:221-8. 1998
    ..p38alpha and C-terminal Flag-tagged p38beta were purified by Q-Sepharose fast flow, hydroxyapatite, and Q-Sepharose high-performance chromatography...
  101. ncbi gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes
    Sandrina Kinet
    Institut de Genetique Moleculaire de Montpellier, Centre National de Recherche Scientifique CNRS UMR 5535 IFR 22, Montpellier, France
    Blood 100:2546-53. 2002
    ..These studies reveal a mechanism via which gp120 may differentially modulate the fate of activated and quiescent T cells in vivo...

Research Grants66

  1. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
    ..g. p38alpha and p38beta, serves as a crucial determinant of myocyte fate...
  2. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..in our lab; (b) western blots from traumatized brain show activation of the MAP kinase pathways ERK and SAPK2/p38; (c) the ERK/MAP kinase pathway upregulates MMP in vitro; (d) MMP activation occurs after trauma in vivo; (e) ..
  3. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
    ..objective is to determine if the p38 kinase that is activated during hypoxia tolerance corresponds to p38alpha, p38beta, p38gamma, or p38delta...
  4. p38alpha and beta MAP Kinases in Endothelial Cells
    Yan Lin Guo; Fiscal Year: 2005
    ..The goal of this research is to investigate the roles for p38alpha and p38beta, two major isoforms expressed in endothelial cells (ECs), in the regulation of EC activities involved in ..
  5. Endothelial Barrier Function Modulation by PKCdelta
    Elizabeth O Harrington; Fiscal Year: 2010
    ..We hope that identification of proteins important in maintaining a non-leaky state will assist in discovering a treatment for patients suffering from lung edema. ..
  6. Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor Suppression
    Peiqing Sun; Fiscal Year: 2010
    ..Results from these studies will define the signal transduction pathway mediating the senescence response and tumor suppression, and may lead to the development of novel cancer therapies targeting the senescence pathway. ..
  7. p53-independent Role of MDM2, TGFb Resistance and Cancer
    Peiqing Sun; Fiscal Year: 2006
    ..These studies will not only offer insights into the diverse pathways leading to the loss of TGFbeta sensitivity in tumors, but also reveal novel roles of MDM2 in tumorigenesis. ..
  8. p38 MAPK in Ras-induced Senescence and Transformation
    Peiqing Sun; Fiscal Year: 2010
    ....
  9. p38 MAPK in Ras-induced Senescence and Transformation
    Peiqing Sun; Fiscal Year: 2009
    ..abstract_text> ..
  10. REGULATION OF CELL ACTIVITIES BY COLLAGEN AND FIBRIN
    Jiahua Xu; Fiscal Year: 2004
    ..abstract_text> ..
  11. Quantitative proteomic analysis of lymphoma transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2006
    ....
  12. Endothelial Barrier Function Modulation by PKCdelta
    Elizabeth Harrington; Fiscal Year: 2007
    ..We hope that identification of proteins important in maintaining a non-leaky state will assist in discovering a treatment for patients suffering from lung edema. ..
  13. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  14. Endothelial Barrier Function Modulation by PKCdelta
    Elizabeth Harrington; Fiscal Year: 2009
    ..We hope that identification of proteins important in maintaining a non-leaky state will assist in discovering a treatment for patients suffering from lung edema. ..
  15. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  16. EXTRACELLULAR MATRIX SIGNALING IN WOUND HEALING
    Jiahua Xu; Fiscal Year: 2002
    ....
  17. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2003
    ..These studies will identify and define the important mechanisms involved in bladder inflammation and provide new insights for developing treatment strategies for cystitis. ..
  18. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  19. 67 KD LAMININ BINDING PROTEIN ON HUMAN T LYMPHOCYTES
    Stephen Canfield; Fiscal Year: 2003
    ..of p67 LBP and the integrin alpha6 to lymphocyte laminin-specific adherence? and (4) What are the contributions of p67 LBP and alpha6 to laminin-mediated lamellipod formation, locomotion, and transendothelial migration? ..