Gene Symbol: MAPK11
Description: mitogen-activated protein kinase 11
Alias: P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11, MAP kinase 11, MAP kinase p38 beta, mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, stress-activated protein kinase-2, stress-activated protein kinase-2b
Species: human
Products:     MAPK11

Top Publications

  1. Jiang Y, Chen C, Li Z, Guo W, Gegner J, Lin S, et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 1996;271:17920-6 pubmed
    ..Here we characterize a new MAP kinase, p38beta. p38beta is a 372-amino acid protein most closely related to p38...
  2. Deak M, Clifton A, Lucocq L, Alessi D. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426-41 pubmed
    ..MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38...
  3. Patel S, Cameron P, O Keefe S, Frantz Wattley B, Thompson J, O Neill E, et al. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. Acta Crystallogr D Biol Crystallogr. 2009;65:777-85 pubmed publisher
    ..Of the four p38 isoforms known to date, two (p38alpha and p38beta) have been identified as targets for cytokine-suppressive anti-inflammatory drugs...
  4. Matrone A, Grossi V, Chiacchiera F, Fina E, Cappellari M, Caringella A, et al. p38alpha is required for ovarian cancer cell metabolism and survival. Int J Gynecol Cancer. 2010;20:203-11 pubmed
    ..Then, we treated these cells with the p38alpha/p38beta-specific inhibitor SB202190 and performed a morphological, proliferation, and survival analyses...
  5. Seisenbacher G, Hafen E, Stocker H. MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet. 2011;7:e1002168 pubmed publisher
    ..By performing a thorough genetic analysis, we demonstrate that a signalling complex consisting of p38b and MK2 forms a branch of SAPK signalling that is required in the larval hindgut to prevent stress-dependent damage ..
  6. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch R, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science. 2002;295:1291-4 pubmed
    ..These findings suggest that alternative activation pathways contribute to the biological responses of p38alpha to various stimuli. ..
  7. Zhang W, Sun J, Luo J. High Expression of Rab-like 3 (Rabl3) is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy. Med Sci Monit. 2016;22:1582-8 pubmed
    ..Interestingly, Rabl3 knockdown was associated with enhanced activation of MAPK8/9/10 but not MAPK11/12/13/14...
  8. Córdova Palomera A, Fatjó Vilas M, Gastó C, Navarro V, Krebs M, Fañanás L. Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins. Transl Psychiatry. 2015;5:e557 pubmed publisher
    ..Complementarily, VMPs were located in genes such as CACNA1C, IGF2 and the p38 MAP kinase MAPK11, showing enrichment for biological processes such as glucocorticoid signaling...
  9. Wongtrakul J, Janphen K, Saisawang C, Ketterman A. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. J Insect Sci. 2014;14:60 pubmed publisher
    ..An in vitro study was performed for Theta, Omega, Sigma GSTs and their interaction with MAP kinase p38b protein from the fruit fly Drosophila melanogaster Meigen (Diptera: Drosophilidae)...

More Information

Publications134 found, 100 shown here

  1. Lou D, Wang H, Yu D. The sucrose non-fermenting-1-related protein kinases SAPK1 and SAPK2 function collaboratively as positive regulators of salt stress tolerance in rice. BMC Plant Biol. 2018;18:203 pubmed publisher
    ..To date, the functions of two rice SnRK2s, osmotic stress/ABA-activated protein kinase 1 (SAPK1) and SAPK2, have been unknown...
  2. Kumar S, McDonnell P, Gum R, Hand A, Lee J, Young P. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997;235:533-8 pubmed
    ..We also cloned an alternative form of p38beta, termed p38beta2, which lacks the additional 8 amino acid insertion unique to p38beta...
  3. Tian Y, Wen H, Qi X, Zhang X, Li Y. Identification of mapk gene family in Lateolabrax maculatus and their expression profiles in response to hypoxia and salinity challenges. Gene. 2019;684:20-29 pubmed publisher
    ..salinity challenge, significant up-regulations were observed in the expressions of mapk8 (jnk1), mapk9 (jnk2), mapk11 (p38β), mapk14a (p38a) and mapk14b (p38b)...
  4. Harrington E, Smeglin A, Parks N, Newton J, Rounds S. Adenosine induces endothelial apoptosis by activating protein tyrosine phosphatase: a possible role of p38alpha. Am J Physiol Lung Cell Mol Physiol. 2000;279:L733-42 pubmed
    ..ERK) 1 activity was slightly elevated in adenosine-treated ECs, whereas ERK2, c-Jun NH(2)-terminal kinase-1, or p38beta activities differed little...
  5. Liu H, Pedram A, Kim J. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38?-mediated activation of p53 and by down-regulating p53 inhibition on p38?. Cardiovasc Res. 2011;89:119-28 pubmed publisher
    ..E2 protects cardiomyocytes by inhibiting p38?-p53 signalling in apoptosis. ..
  6. Fan Y, Du Z, Steib C, Ding Q, Lu P, Tian D, et al. Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism. Lab Invest. 2019;99:17-36 pubmed publisher
  7. Kurita H, Schnekenburger M, Ovesen J, Xia Y, Puga A. The Ah receptor recruits IKK? to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicol Sci. 2014;139:121-32 pubmed publisher
    ..kinases, I?B kinase ? (IKK?), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells ..
  8. Umasuthan N, Bathige S, Noh J, Lee J. Gene structure, molecular characterization and transcriptional expression of two p38 isoforms (MAPK11 and MAPK14) from rock bream (Oplegnathus fasciatus). Fish Shellfish Immunol. 2015;47:331-43 pubmed publisher
    ..The p38 subfamily that includes four members namely p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13), regulates the activation of several transcription factors...
  9. Adewumi I, López C, Davie J. Mitogen and stress- activated protein kinase regulated gene expression in cancer cells. Adv Biol Regul. 2019;71:147-155 pubmed publisher
    ..In this paper, we focus on the mitogen- and stress-activated protein kinases; their discovery, activation, H3 phosphorylation and recent discoveries in their roles in cancer. ..
  10. Md Aksam V, Chandrasekaran V, Pandurangan S. Topological alternate centrality measure capturing drug targets in the network of MAPK pathways. IET Syst Biol. 2018;12:226-232 pubmed publisher
    ..nodes ERK1, ERK2, MEKK2, MKK5, MKK4, MLK3, MLK2, MLK1, MEKK4, MEKK1, TAK1, P38alpha, ZAK, DLK, LZK, MLTKa/b and P38beta as efficient drug targets for breast cancer...
  11. Shin J, Park B, Cho S, Lee S, Kim Y, Lee S, et al. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. J Biol Chem. 2004;279:40994-1003 pubmed
    ..In the current study, we demonstrate that PML negatively regulated the SAPK2/p38 signaling pathway by sequestering p38 from its upstream kinases, MKK3, MKK4, and MKK6, whereas PML did not ..
  12. Moïse N, Dingar D, Mamarbachi A, Villeneuve L, Farhat N, Gaestel M, et al. Characterization of a novel MK3 splice variant from murine ventricular myocardium. Cell Signal. 2010;22:1502-12 pubmed publisher
    ..p38alpha appears pro-apoptotic whereas p38beta is pro-hypertrophic...
  13. Pham H, Vincenti R, Slice L. COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Biochim Biophys Acta. 2008;1779:408-13 pubmed publisher
    ..These data demonstrate that in IEC-18 cells, Ang II-dependent activation of the COX-2 promoter is mediated primarily through Gq/11 signaling via a PAK/MKK6/p38beta/CREB signaling cascade.
  14. Tian L, Chen J, Chen M, Gui C, Zhong C, Hong L, et al. The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU. J Biol Chem. 2014;289:31856-65 pubmed publisher
    ..However, the underlying mechanisms are largely unknown. In the present study, we demonstrate that p38b is a major p38 MAPK involved in the regulation of oxidative stress tolerance in addition to p38a and p38c in ..
  15. Zhang D, Li Y, Wang R, Li Y, Shi P, Kan Z, et al. Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..and migration inhibition demonstrated that CCND1 and CCNE1 were reduced; CDK5R1, BBC3, EGR1, SLC25A4, PDCD7, MAPK11, MAPK12, FADD and DAXX were enhanced, among which BBC3 and DAXX were direct targets of REST, as verified by ChIP (..
  16. Kuma Y, Campbell D, Cuenda A. Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta. Biochem J. 2004;379:133-9 pubmed
    The endogenous glycogen synthase in extracts from mouse skeletal muscle, liver and brain bound specifically to SAPK2b (stress-activated protein kinase 2b)/p38b, but not to other members of the group of SAPK/p38 kinases...
  17. Jans R, Atanasova G, Jadot M, Poumay Y. Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J Invest Dermatol. 2004;123:564-73 pubmed
  18. Waterworth D, Li L, Scott R, Warren L, Gillson C, Aponte J, et al. A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker. J Am Heart Assoc. 2014;3: pubmed publisher
    ..protein kinase inhibitor in development for acute coronary syndrome, we characterized gene variation in MAPK11/14 genes by exome sequencing and follow-up genotyping or imputation in participants well-phenotyped for ..
  19. Lewis J, Mejia C, Jordan C, Monson T, Bodine J, Dunaway T, et al. Inhibition of the receptor for advanced glycation end-products (RAGE) protects from secondhand smoke (SHS)-induced intrauterine growth restriction IUGR in mice. Cell Tissue Res. 2017;370:513-521 pubmed publisher
    ..These studies provide insight into tobacco-mediated IUGR development and clarify avenues that may be helpful in the alleviation of placental complications. ..
  20. Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, et al. Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2. Blood Cells Mol Dis. 2015;55:21-6 pubmed publisher
    ..Neither SB203580 (a p38alpha/p38beta inhibitor) nor BIRB796 (a p38gamma/p38delta inhibitor) affected IL-13 production, while TMB-8 (a calcium chelator)..
  21. Browne A, Göbel A, Thiele S, Hofbauer L, Rauner M, Rachner T. p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells. Cell Death Dis. 2016;7:e2119 pubmed publisher
    ..Further dissection by targeting individual p38 MAPK isoforms with siRNA revealed a stronger role for MAPK11 than MAPK14 and MAPK12 in the regulation of DKK-1...
  22. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood L, et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998;17:3372-84 pubmed
    ..PRAK activity was regulated by p38alpha and p38beta both in vitro and in vivo and Thr182 was shown to be the regulatory phosphorylation site...
  23. Beatty S, Rached D Astous L, Malo D. Complex genetics architecture contributes to Salmonella resistance in AcB60 mice. Mamm Genome. 2017;28:38-46 pubmed publisher
    ..infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional ..
  24. Rolli Derkinderen M, Gaestel M. p38/SAPK2-dependent gene expression in Jurkat T cells. Biol Chem. 2000;381:193-8 pubmed
    The stress-activated protein kinase p38/SAPK2 is known to regulate the activity of transcription factors and to control expression of several genes at the transcriptional or post-transcriptional level...
  25. He Z, He J, Liu Z, Xu J, Yi S, Liu H, et al. MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption. Biochimie. 2014;106:24-32 pubmed publisher
    ..However the underlying mechanism is poorly understood. This study shows that the p38 MAPK (p38) isoform MAPK11 (p38?) is expressed in breast cancer cells...
  26. Wu H, Meng S, Xu Q, Wang X, Wang J, Gong R, et al. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Eur J Cancer Prev. 2016;25:508-17 pubmed publisher
    ..The tendency of changes in the expression of 12 selected DEGs (five downregulated genes, PIK3R1, RARB, HGF, MAPK11, and SESN1, and seven upregulated genes, PAK1, E2F1, CCNE1, EGF, CDC25A, PTTG1, and UHRF1) in RTq-PCR was ..
  27. Landry J, Huot J. Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27). Biochem Soc Symp. 1999;64:79-89 pubmed
    Activation of the mitogen-activated protein kinase (MAP kinase) SAPK2 (stress-activated protein kinase 2) leads to the phosphorylation of several transcription factors and cytoplasmic proteins, and thereby presumably orchestrates ..
  28. Camuzeaux B, Diring J, Hamard P, Oulad Abdelghani M, Donzeau M, Vigneron M, et al. p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive. J Mol Biol. 2008;384:980-91 pubmed publisher
    ..the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase...
  29. Yu L, Yuan X, Wang D, Barakat B, Williams E, Hannigan G. Selective regulation of p38? protein and signaling by integrin-linked kinase mediates bladder cancer cell migration. Oncogene. 2014;33:690-701 pubmed publisher
    ..Our work identifies Hsp27 as a novel target of ILK-p38? signaling complexes, playing a key role in bladder cancer cell migration. ..
  30. Dusik V, Senthilan P, Mentzel B, Hartlieb H, Wülbeck C, Yoshii T, et al. The MAP kinase p38 is part of Drosophila melanogaster's circadian clock. PLoS Genet. 2014;10:e1004565 pubmed publisher
    ..of the clock protein Period was significantly delayed on the expression of a dominant-negative form of p38b in Drosophila's most important clock neurons...
  31. Chakrabarti S, Poidevin M, Lemaitre B. The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine. PLoS Genet. 2014;10:e1004659 pubmed publisher
    ..The Drosophila genome encodes three p38 kinases named p38a, p38b and p38c. In this study, we have analyzed the role of p38c in the Drosophila intestine...
  32. Zhan L, Xie Q, Tibbetts R. Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Hum Mol Genet. 2015;24:757-72 pubmed publisher
    ..LOF alleles of the p38b gene as well as p38 inhibitors diminished TDP-43-associated premature lethality, whereas p38b GOF caused phenotypic ..
  33. Kim G, Kim H, Lim H, Park H. Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation. Cell Signal. 2015;27:1688-93 pubmed publisher
    ..These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38β expression and activation. ..
  34. Thamodaran V, Bruce A. p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development. Open Biol. 2016;6: pubmed publisher
    ..However, we report that p38 family mitogen-activated protein kinases (namely p38α/Mapk14 and p38β/Mapk11; referred to as p38-Mapk14/11) also participate in PrE formation...
  35. Cuenda A, Cohen P, Buee Scherrer V, Goedert M. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J. 1997;16:295-305 pubmed
    ..stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF) in a similar manner to SAPK1 (also termed JNK) and SAPK2 (also termed p38, RK, CSBP and Mxi2)...
  36. Huot J, Houle F, Rousseau S, Deschesnes R, Shah G, Landry J. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis. J Cell Biol. 1998;143:1361-73 pubmed
    ..results from the activation of the mitogen-activated protein (MAP) kinase stress-activated protein kinase-2/p38 (SAPK2/p38), which, via MAP kinase-activated protein (MAPKAP) kinase-2/3, leads to the phosphorylation of the actin ..
  37. Handu M, Kaduskar B, Ravindranathan R, Soory A, Giri R, Elango V, et al. SUMO-Enriched Proteome for Drosophila Innate Immune Response. G3 (Bethesda). 2015;5:2137-54 pubmed publisher
    ..These include components of immune signaling pathways such as Caspar, Jra, Kay, cdc42, p38b, 14-3-3ε, as well as cellular proteins with diverse functions, many being components of protein complexes, such as ..
  38. Sawada J, Li F, Komatsu M. R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells. J Vasc Res. 2015;52:347-59 pubmed publisher
    ..the VEGF-dependent activation of stress-activated protein kinase-2/p38 mitogen-activated protein kinase (SAPK2/p38MAPK) and the phosphorylation of downstream heat-shock protein 27 (HSP27), a regulator of actin cytoskeleton ..
  39. Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman F, Taylor N. gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes. Blood. 2002;100:2546-53 pubmed
    ..These studies reveal a mechanism via which gp120 may differentially modulate the fate of activated and quiescent T cells in vivo. ..
  40. Zong W, Tang N, Yang J, Peng L, Ma S, Xu Y, et al. Feedback Regulation of ABA Signaling and Biosynthesis by a bZIP Transcription Factor Targets Drought-Resistance-Related Genes. Plant Physiol. 2016;171:2810-25 pubmed publisher
    ..A homolog of SnRK2 protein kinase (SAPK2) was found to interact with and phosphorylate OsbZIP23 for its transcriptional activation...
  41. Hale K, Trollinger D, Rihanek M, Manthey C. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J Immunol. 1999;162:4246-52 pubmed
    ..p38alpha was the dominant form of p38 in monocytes; expression of p38delta was low and p38beta was undetected. In macrophages, p38alpha and p38delta were abundant, but p38beta was undetected...
  42. Wong J, Campbell G, Spector S. Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins. J Biol Chem. 2010;285:18319-25 pubmed publisher
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  43. Hsu Y, Wang M, Ho L, Huang C, Lai J. Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J Cell Mol Med. 2015;19:1065-76 pubmed publisher
    ..In summary, this study reveals the roles of Gal-9 in DV-induced migration of DCs. The findings indicate that Gal-9 might be a therapeutic target for preventing immunopathogenesis induced by DV infection. ..
  44. Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, et al. Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Res. 2017;27:1441-1465 pubmed publisher
    ..Here we report two kinases HIPK3 and MAPK11 as positive modulators of mHTT levels both in cells and in vivo...
  45. Kroviarski Y, Debbabi M, Bachoual R, Perianin A, Gougerot Pocidalo M, El Benna J, et al. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. FASEB J. 2010;24:2077-92 pubmed publisher
    ..These results demonstrated a critical role of NOXA1 phosphorylation on Ser-282 and Ser-172 in preventing NOX1 hyperactivation through the decrease of NOXA1 interaction to NOX1 and Rac1. ..
  46. Aenlle K, Curtis K, Roos B, Howard G. Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells. Mol Endocrinol. 2014;28:722-30 pubmed publisher
    ..In summary, our data demonstrate the importance of p38 signaling in HGF regulation of osteogenic differentiation. ..
  47. Rolli M, Kotlyarov A, Sakamoto K, Gaestel M, Neininger A. Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. J Biol Chem. 1999;274:19559-64 pubmed
    The p38/stress-activated protein kinase2 (p38/SAPK2) is activated by cellular stress and proinflammatory cytokines...
  48. Cross H, Li M, Petrich B, Murphy E, Wang Y, Steenbergen C. Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. Acta Physiol Hung. 2009;96:307-23 pubmed publisher
    ..mice with cardiac-specific expression of kinase dead (dominant negative) mutants of p38alpha (p38alphadn) or p38beta (p38betadn). Hearts were subjected to 20 min ischemia and 40 min reperfusion...
  49. Kogai T, Liu Y, Mody K, Shamsian D, Brent G. Regulation of sodium iodide symporter gene expression by Rac1/p38? mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 2012;287:3292-300 pubmed publisher
    ..Targeting isoform-selective activation of p38 may enhance NIS induction, resulting in higher efficacy of (131)I concentration and treatment of breast cancer. ..
  50. Lal A, Clifton A, Rouse J, Segal A, Cohen P. Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38. Biochem Biophys Res Commun. 1999;259:465-70 pubmed
    ..acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38...
  51. Laferriere J, Houle F, Taher M, Valerie K, Huot J. Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells. J Biol Chem. 2001;276:33762-72 pubmed
    ..We investigated the roles of E-selectin and of stress-activated protein kinase-2 (SAPK2/p38) in modulating endothelial adhesion and transendothelial migration of HT-29 colon carcinoma cells...
  52. Lim S, Zou Y, Friedman E. The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. J Biol Chem. 2002;277:49438-45 pubmed
    ..Only the p38alpha and p38beta isoforms, but not the gamma or delta isoforms, complexed with Mirk...
  53. Vitale S, Schmid Alliana A, Breuil V, Pomeranz M, Millet M, Rossi B, et al. Soluble fractalkine prevents monocyte chemoattractant protein-1-induced monocyte migration via inhibition of stress-activated protein kinase 2/p38 and matrix metalloproteinase activities. J Immunol. 2004;172:585-92 pubmed
    ..In this study, we found that stress-activated protein kinase (SAPK)1/c-Jun N-terminal kinase 1 and SAPK2/p38 are involved in the control of MCP-1-induced MonoMac6 cell migration...
  54. Ferrari G, Terushkin V, Wolff M, Zhang X, Valacca C, Poggio P, et al. TGF-?1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38? to proapoptotic p38?. Mol Cancer Res. 2012;10:605-14 pubmed publisher
    ..Therefore, these results show that TGF-?1 induces endothelial cell apoptosis by shifting VEGF signaling from the prosurvival p38? to the proapoptotic p38?. ..
  55. Sun P, Yoshizuka N, New L, Moser B, Li Y, Liao R, et al. PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007;128:295-308 pubmed
    ..Furthermore, we show that PRAK activates p53 by direct phosphorylation. We propose that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras-induced senescence and tumor suppression. ..
  56. Kumar R, Janjanam J, Singh N, Rao G. A new role for cofilin in retinal neovascularization. J Cell Sci. 2016;129:1234-49 pubmed publisher
    ..of Pak1 and its effector cofilin in a manner that was dependent on time as well as p38MAPKβ (also known as MAPK11) in human retinal microvascular endothelial cells (HRMVECs)...
  57. Wang J, Tasinato A, Ethell D, Testa M, Bredesen D. Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities. J Mol Neurosci. 2000;15:19-29 pubmed
    ..Using the yeast two-hybrid system, we identified the mitogen-activated protein (MAP) kinase p38beta2 as a specific interactor with the 5th and 6th alpha helices of the p75NTR intracytoplasmic region...
  58. Huang D, Li X, Sun L, Huang P, Ying H, Wang H, et al. Regulation of Hippo signalling by p38 signalling. J Mol Cell Biol. 2016;8:328-37 pubmed publisher
    ..Epistasis analysis indicates that Mekk1 and lic affect Hippo signalling via p38b and wts We further demonstrate that the Mekk1-Lic-p38b cascade inhibits Hippo signalling by promoting F-actin ..
  59. Shah N, Tulapurkar M, Ramarathnam A, Brophy A, Martinez R, HOM K, et al. Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity. J Immunol. 2017;198:3296-3306 pubmed publisher
    ..g., p38β/MAPK11) and loss of all p38α-dependent responses, including anti-inflammatory, counterregulatory responses via mitogen-..
  60. Takahashi M, Gotoh Y, Isagawa T, Nishimura T, Goyama E, Kim H, et al. Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. J Biochem. 2003;133:181-7 pubmed
    ..These results suggest that PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway. ..
  61. Casanovas O, Jaumot M, Paules A, Agell N, Bachs O. P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation. Oncogene. 2004;23:7537-44 pubmed
    ..Alterations of this mechanism might be important for oncogenesis. ..
  62. Yamaguchi R, Kawata J, Yamamoto T, Ishimaru Y, Sakamoto A, Ono T, et al. Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps. Blood Cells Mol Dis. 2015;55:127-33 pubmed publisher
    ..Neither a combined p38alpha and p38beta inhibitor (SB203580) nor an extracellular signal-regulated kinase inhibitor (PD98059) suppressed IFN-gamma ..
  63. Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 1997;16:3563-71 pubmed
    ..and SAP-1 at similar rates, but were far less effective than SAPK2a (also called RK/p38) or SAPK2b (also called p38beta) in activating MAPKAP kinase-2 and MAPKAP kinase-3...
  64. Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, et al. Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem. 2001;276:39027-36 pubmed
    ..These data demonstrate that the molecular mechanisms underlying the survival factor function of NGF critically rely upon the continuous inactivation of p38 MAPK, a Bcl-2-modifying enzyme. ..
  65. Barajas Espinosa A, Basye A, Angelos M, Chen C. Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress. Free Radic Biol Med. 2015;89:170-81 pubmed publisher
    ..Therefore, the identification of p38 kinase modulation by DUSP4 provides a novel therapeutic target for oxidant-induced diseases, especially myocardial infarction. ..
  66. Bhatnagar N, Min M, Choi E, Kim N, Moon S, Yoon I, et al. The protein phosphatase 2C clade A protein OsPP2C51 positively regulates seed germination by directly inactivating OsbZIP10. Plant Mol Biol. 2017;93:389-401 pubmed publisher
    ..Furthermore, interactions were observed between OsPP2C51 and SAPK2, and between OsPP2C51 and OsbZIP10 and we found out that OsPP2C51 can dephosphorylates OsbZIP10...
  67. Tanoue T, Yamamoto T, Maeda R, Nishida E. A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem. 2001;276:26629-39 pubmed
    ..MKP-5 and CL100/MKP-1 also bind to p38 alpha and -beta, but not gamma or delta. Finally, we propose a tentative classification of MKPs based on the sequence characteristics of their MAPK-docking site. ..
  68. Knebel A, Haydon C, Morrice N, Cohen P. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Biochem J. 2002;367:525-32 pubmed
    ..Since the phosphorylation of Ser-377 does not inhibit eEF2 kinase in vitro, our results suggest that anisomycin or TNF-alpha inhibit eEF2 kinase via the phosphorylation of Ser-359. ..
  69. Yang S, Galanis A, Sharrocks A. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol. 1999;19:4028-38 pubmed
    ..factors MEF2A and MEF2C are preferentially phosphorylated and activated by the p38 subfamily members p38alpha and p38beta2. The efficiency of phosphorylation in vitro and transcriptional activation in vivo of MEF2A and MEF2C by these ..
  70. Dorion S, Berube J, Huot J, Landry J. A short lived protein involved in the heat shock sensing mechanism responsible for stress-activated protein kinase 2 (SAPK2/p38) activation. J Biol Chem. 1999;274:37591-7 pubmed
    The stress-activated protein kinase 2 (SAPK2/p38) is activated by various environmental stresses and also by a vast array of agonists including growth factors and cytokines...
  71. Fearns C, Kline L, Gram H, Di Padova F, Zurini M, Han J, et al. Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli. J Leukoc Biol. 2000;67:705-11 pubmed
    ..Without stimulation endogenous p38alpha kinase activity was readily detectable, whereas that of p38beta, gamma, and delta was barely measurable...
  72. Vockerodt M, Haier B, Buttgereit P, Tesch H, Kube D. The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway. Virology. 2001;280:183-98 pubmed
    ..kappa B-alpha only marginally impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM (a specific p38/SAPK2 inhibitor) led to reduced IL-10 expression...
  73. Pramanik R, Qi X, Borowicz S, Choubey D, Schultz R, Han J, et al. p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem. 2003;278:4831-9 pubmed
    ..The p38beta isoform increases the activation of AP-1 transcriptional activities by MKK6 and/or arsenite, whereas p38gamma/..
  74. Park M, Choi J, Kim M, Um H, Bae S, Kang C, et al. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J Biol Chem. 2003;278:50624-34 pubmed
    ..Molecular dissection of the signaling pathways that activate the apoptotic cell death machinery is critical for both our understanding of cell death events and development of cancer therapeutic agents. ..
  75. Hendrickx N, Volanti C, Moens U, Seternes O, de Witte P, Vandenheede J, et al. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J Biol Chem. 2003;278:52231-9 pubmed
  76. Avitzour M, Diskin R, Raboy B, Askari N, Engelberg D, Livnah O. Intrinsically active variants of all human p38 isoforms. FEBS J. 2007;274:963-75 pubmed
    ..The four mammalian isoforms (p38alpha, p38beta, p38gamma, and p38delta) are coexpressed and coactivated in the same cells...
  77. Plun Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, et al. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. 2007;9:1243-52 pubmed
    ..We suggest that PINK1-dependent phosphorylation of HtrA2 might modulate its proteolytic activity, thereby contributing to an increased resistance of cells to mitochondrial stress. ..
  78. Sundivakkam P, Natarajan V, Malik A, Tiruppathi C. Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38? mitogen-activated protein kinase. J Biol Chem. 2013;288:17030-41 pubmed publisher
    ..Thus, our findings demonstrate that SOCE activates CaMKK?-AMPK?1-p38? MAPK signaling to phosphorylate STIM1, thereby suppressing endothelial SOCE and permeability responses. ..
  79. Liu X, Kumar A. Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes. Sci Rep. 2015;5:9867 pubmed publisher
    ..These results offer new potential targets to develop therapeutic strategy for treatment of HIV-1 associated neurological disorders, prevalent in > 40% of individuals infected with HIV-1. ..
  80. Tejwani L, Lim J. Hunting for the mutant without the MAP(K). Cell Res. 2017;: pubmed publisher
    In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) ..
  81. Janknecht R. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem. 2001;276:41856-61 pubmed
    ..Altogether, MK2 may regulate ER81 transcriptional activity in a cell type-specific manner and thereby modulate various physiological processes beyond stress responses. ..
  82. Lamalice L, Houle F, Jourdan G, Huot J. Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene. 2004;23:434-45 pubmed
    ..Yet, nothing is known about the molecular mechanisms that couple VEGFR2 to SAPK2/p38...
  83. Zvalova D, Cordier J, Mesnil M, Junier M, Chneiweiss H. p38/SAPK2 controls gap junction closure in astrocytes. Glia. 2004;46:323-33 pubmed
    ..The inhibition of p38/stress-activated protein kinase 2 (p38/SAPK2) by a pyrimidyl imidazole derivative has been reported to reduce the extent of the lesion area after cerebral ..
  84. Lamalice L, Houle F, Huot J. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem. 2006;281:34009-20 pubmed
    ..that following VEGF treatment of endothelial cells, VEGFR-2 is phosphorylated on Tyr1214 upstream of the Cdc42-SAPK2/p38-MAPKAP K2 pathway...
  85. Sebe A, Leivonen S, Fintha A, Masszi A, Rosivall L, Kahari V, et al. Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling durin. Nephrol Dial Transplant. 2008;23:1537-45 pubmed publisher
    ..Adenoviral expression of dominant negative (DN) p38beta but not of p38alpha potently inhibited alphaSMA expression...
  86. Si H, Liu D. Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase. Apoptosis. 2009;14:66-76 pubmed publisher
    ..Accordingly, stimulation of HAECs with genistein resulted in rapid activation of p38beta, but not p38alpha...
  87. Zheng S, Yang C, Liu T, Liu Q, Dai F, Sheyhidin I, et al. Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma. Tumour Biol. 2016;37:7255-66 pubmed publisher
    ..Together, our results demonstrate that p38β, p38γ, and p38δ played oncogenic roles in ESCC. ..
  88. Yin J, Wang A, Li W, Shi R, Jin H, Wei J. Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Environ Toxicol Pharmacol. 2017;56:340-349 pubmed publisher
    ..Cd induced an early activation of ERK2 and a delayed activation of p38a, p38b, ERK3 and JNK1, indicating that the JNK1 pathway is sensitive to Pb exposure, while the p38 pathway may be ..
  89. Stein B, Yang M, Young D, Janknecht R, Hunter T, Murray B, et al. p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997;272:19509-17 pubmed
    ..A sequential kinetic mechanism of p38-2 is suggested by steady state kinetic analysis. In conclusion, p38-2 may be an important component of the stress response required for the homeostasis of a cell. ..
  90. Casanovas O, Miro F, Estanyol J, Itarte E, Agell N, Bachs O. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J Biol Chem. 2000;275:35091-7 pubmed
    ..In the case of osmotic shock, this effect was completely reversed by the addition of p38(SAPK2)-specific inhibitors (SB203580 or SB220025), indicating that this effect is dependent on p38(SAPK2) activity...
  91. Naderi J, Hung M, Pandey S. Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress. Apoptosis. 2003;8:91-100 pubmed
    ..Furthermore, our results also suggest that the p38MAPK activation-Bax expression pathway might be involved in apoptosis induced by oxidative stress. ..
  92. Tanos T, Marinissen M, Leskow F, Hochbaum D, Martinetto H, Gutkind J, et al. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem. 2005;280:18842-52 pubmed
    ..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation. ..