MAPK10

Summary

Gene Symbol: MAPK10
Description: mitogen-activated protein kinase 10
Alias: JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10, JNK3 alpha protein kinase, MAP kinase 10, MAP kinase p49 3F12, c-Jun N-terminal kinase 3, stress activated protein kinase beta, stress-activated protein kinase 1b, stress-activated protein kinase JNK3
Species: human
Products:     MAPK10

Top Publications

  1. Park J, Yun Y, Chung K. Conformations of JNK3α splice variants analyzed by hydrogen/deuterium exchange mass spectrometry. J Struct Biol. 2017;197:271-278 pubmed publisher
    ..C-terminal tail and investigated conformational differences between long and short splice variants of JNKs using JNK3α2 and JNK3α1 as models...
  2. Jang W, Lee J, Lee S, Jun D, Kim Y. Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells. Biochem Biophys Res Commun. 2014;452:845-51 pubmed publisher
    Exposure of human Jurkat T cells to JNK inhibitor IX (JNKi), targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase ..
  3. Pan J, Li H, Zhang B, Xiong R, Zhang Y, Kang W, et al. Small peptide inhibitor of JNK3 protects dopaminergic neurons from MPTP induced injury via inhibiting the ASK1-JNK3 signaling pathway. PLoS ONE. 2015;10:e0119204 pubmed publisher
    The ASK1-JNK3 signaling pathway plays a pivotal role in the pathogenesis of Parkinson's disease (PD)...
  4. Castro Torres R, Landa J, Rabaza M, Busquets O, Olloquequi J, Ettcheto M, et al. JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy. Mol Neurobiol. 2019;: pubmed publisher
    ..The purpose of this study was to analyze the role of JNK isoforms (JNK1/JNK2/JNK3) in adult-hippocampal neurogenesis...
  5. Manassero G, Repetto I, Cobianchi S, Valsecchi V, Bonny C, Rossi F, et al. Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse. Mol Pain. 2012;8:39 pubmed publisher
    ..Autotomy behavior, typically induced by sciatic nerve axotomy, was absent in both the JNK1 and JNK3 knockout mice...
  6. Ginet V, Puyal J, Magnin G, Clarke P, Truttmann A. Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia. J Neurochem. 2009;108:552-62 pubmed publisher
    ..in JNK phosphorylation (reflecting mainly JNK1 phosphorylation) followed by a slow progressive increase (including JNK3 phosphorylation 54 kDa), whereas c-jun and c-fos expression were both strongly activated immediately after HI...
  7. Sala M, Chen C, Zhang Q, Do Umehara H, Wu W, Misharin A, et al. JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension. J Biol Chem. 2018;293:271-284 pubmed publisher
    ..protein kinase that consists of two ubiquitously expressed isoforms, JNK1 and JNK2, and a tissue-specific isoform, JNK3, has been shown to be activated by hypoxia...
  8. Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O Keefe S, et al. Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1. Biochemistry. 2000;39:3141-8 pubmed
    b>JNK3 alpha 1 is predominantly a neuronal specific MAP kinase that is believed to require, like all MAP kinases, both threonine and tyrosine phosphorylation for maximal enzyme activity...
  9. Gu X, Yang W, Luo X, Wang X, Tang J, Cai Z. Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea. Sleep Breath. 2019;23:259-267 pubmed publisher
    ..Epstein-Barr virus infection (involving IL10RB, MAPK9, and MAPK10) and olfactory transduction were the main pathways separately enriched for the upregulated genes and the ..

More Information

Publications169 found, 100 shown here

  1. Kook S, Vishnivetskiy S, Gurevich V, Gurevich E. Cleavage of arrestin-3 by caspases attenuates cell death by precluding arrestin-dependent JNK activation. Cell Signal. 2019;54:161-169 pubmed publisher
    ..We found that caspase cleavage did not affect the binding of the arrestin-3 to JNK3, but prevented facilitation of its activation, in contrast to the caspase-resistant mutant, which facilitated JNK ..
  2. Negri S, Oberson A, Steinmann M, Sauser C, Nicod P, Waeber G, et al. cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Genomics. 2000;64:324-30 pubmed
    ..These data establish IB2 as a novel scaffold protein that regulates the JNK signaling pathway in brain and pancreatic beta-cells and indicate that IB2 represents a novel candidate gene for diabetes. ..
  3. Abdelli S, Bonny C. JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. PLoS ONE. 2012;7:e35997 pubmed publisher
    We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects...
  4. Liu L, Fox C, North T, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013;6:1271-8 pubmed publisher
    ..Knockdown of three genes (pnpla3, pklr and mapk10) decreased expression of hepatic progenitor cells, whereas knockdown of eight genes (pnpla3, cpn1, trib1, fads2, ..
  5. Schepetkin I, Khlebnikov A, Potapov A, Kovrizhina A, Matveevskaya V, Belyanin M, et al. Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors. Eur J Med Chem. 2019;161:179-191 pubmed publisher
    ..Several compounds exhibited sub-micromolar JNK binding affinity and were selective for JNK1/JNK3 versus JNK2...
  6. Song Y, Dai C, Li M, Cui M, Ding X, Zhao X, et al. The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats. Behav Brain Res. 2019;359:528-535 pubmed publisher
    ..This study aimed to ascertain whether the neuroprotective effect of HO-1 depends on the assembly of the MLK3-MKK7-JNK3 signaling module scaffolded by JIP1 and further influences the JNK signal transmission through HO-1...
  7. Liu Y, Chen Y, Wen L, Cui G. Molecular mechanisms underlying the time-dependent autophagy and apoptosis induced by nutrient depletion in multiple myeloma: a pilot study. J Huazhong Univ Sci Technolog Med Sci. 2012;32:1-8 pubmed publisher
    ..RT-PCR and qRT-PCR were used to evaluate the transcriptional levels of Deptor, JNK1, JNK2, JNK3, Raf-1, p53, p21 and NF?B1 at 0, 6, 12, 18, 24 and 48 h after nutrient depletion in RPMI8226 cells...
  8. Pirianov G, MacIntyre D, Lee Y, Waddington S, Terzidou V, Mehmet H, et al. Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality. Reproduction. 2015;150:269-77 pubmed publisher
    ..In addition, we report that D-JNKI inhibits the activation of JNK/JNK3 and caspase-3, which are important mediators of neural cell death in the neonatal brain...
  9. Christensen D, Ejlerskov P, Rasmussen I, Vilhardt F. Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis. J Neuroinflammation. 2016;13:59 pubmed publisher
    ..Pharmacological inhibition or genetic (shRNA) knockdown of JNK2 or JNK3 decreases α-SNC secretion in differentiated PC12 and SH-SY5Y cells, respectively...
  10. Xu L, Jiang C, Lam T, Zhang W, Zhu F, Jin Y, et al. Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study. Hum Mol Genet. 2017;26:430-437 pubmed publisher
    ..We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD ..
  11. Freedman B, Liu Q, Del Corno M, Collman R. HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. Immunol Res. 2003;27:261-76 pubmed
  12. Kim M, Lee J, Hah J. De Novo Design and Synthesis of a γ-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand. Chem Asian J. 2015;10:1318-26 pubmed publisher
    As a way to develop a neuroprotective agent for the JNK3-JIP1-binding site, peptidomimetics of JIP-1 as JNK3 allosteric regulators have been examined...
  13. Gupta R, Ghosh S. Phosphorylation of voltage-dependent anion channel by c-Jun N-terminal Kinase-3 leads to closure of the channel. Biochem Biophys Res Commun. 2015;459:100-6 pubmed publisher
    Stress activated c-Jun N-terminal Kinase-3 (JNK3) has been reported to act on mitochondrion to promote neuronal cell death...
  14. Auladell C, de Lemos L, Verdaguer E, Ettcheto M, Busquets O, Lazarowski A, et al. Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration. Front Biosci (Landmark Ed). 2017;22:795-814 pubmed
    ..Among the three isoforms of JNK (JNK1, JNK2, JNK3), JNK3 is widely localized in the majority of areas of the hippocampus, whereas JNK1 levels are located exclusively ..
  15. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..transmembrane channels, transcription regulators FOS, FOXO6, SCX, STAT5A, ZFPM2, ZNF396, ZNF467, protein kinases MAPK10, MAPK13, MERTK, FLT1, PRKCH, ROS1, TTN), phosphatases PTPRD, PTPRR, peptidases, metabolic enzymes, a chaperone (..
  16. Perry N, Kaoud T, Ortega O, Kaya A, Marcus D, Pleinis J, et al. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Proc Natl Acad Sci U S A. 2019;116:810-815 pubmed publisher
    ..Here, we used arrestin-3, a scaffold of the ASK1-MKK4/7-JNK3 cascade, as a model to understand signal amplification by a scaffold protein...
  17. Dai F, Zhang Y, Chen Y. Involvement of miR-29b signaling in the sensitivity to chemotherapy in patients with ovarian carcinoma. Hum Pathol. 2014;45:1285-93 pubmed publisher
    ..RNA (mRNA) and its targeted genes, myeloid cell leukemia sequence 1, mitogen-activated protein kinase 10 (MAPK10), and autophagy-related protein 9A (ATG9A), were investigated in ovarian carcinomas, and their associations with ..
  18. Wen X, Fu Y, Liu H, Wu J, Shao X, Zhang X, et al. Neuroprotection of Sevoflurane Against Ischemia/Reperfusion-Induced Brain Injury Through Inhibiting JNK3/Caspase-3 by Enhancing Akt Signaling Pathway. Mol Neurobiol. 2016;53:1661-1671 pubmed publisher
    ..Immunoblotting and immunoprecipitation were performed to measure the phosphorylation of Akt1, PRAS40, ASK1, and JNK3 and the expression of cleaved-caspase-3...
  19. Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
    ..b>JNK3 activation causes endothelial cell death...
  20. Shao M, Liu W, Wang Y. Differentially expressed LncRNAs as potential prognostic biomarkers for glioblastoma. Cancer Genet. 2018;226-227:23-29 pubmed publisher
    ..Their neighborhood genes were mostly enriched in genes sets of RTN1 and MAPK10.The characterization of differentially expressed lncRNAs was found out and the mostly enriched pathways were ..
  21. Li Y, Zhang L, Liu Z. Multi-objective de novo drug design with conditional graph generative model. J Cheminform. 2018;10:33 pubmed publisher
    ..to solve several drug design problems, including the generation of compounds containing a given scaffold, compounds with specific drug-likeness and synthetic accessibility requirements, as well as dual inhibitors against JNK3 and GSK-3?.
  22. McDonald P, Chow C, Miller W, Laporte S, Field M, Lin F, et al. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000;290:1574-7 pubmed
    ..We identified c-Jun amino-terminal kinase 3 (JNK3) as a binding partner of beta-arrestin 2 using a yeast two-hybrid screen and by coimmunoprecipitation from mouse ..
  23. Messoussi A, Feneyrolles C, Bros A, Deroide A, Daydé Cazals B, Chevé G, et al. Recent progress in the design, study, and development of c-Jun N-terminal kinase inhibitors as anticancer agents. Chem Biol. 2014;21:1433-43 pubmed publisher
    The c-Jun N-terminal kinase (JNK) family, with its three members JNK1, JNK2, and JNK3, is a subfamily of mitogen-activated protein kinases...
  24. Du C, Liu X, Zeng G, Jin H, Tang L. Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells. Int J Mol Med. 2015;35:1767-72 pubmed publisher
    ..Furthermore, both SB203580 (a specific inhibitor of p38) and SP600125 (JNK1, JNK2 and JNK3 inhibitor) diminished the Ang II-induced production of CTGF; however, the inhibition of FPPS reduced the Ang II-..
  25. Chimnaronk S, Sitthiroongruang J, Srisucharitpanit K, Srisaisup M, Ketterman A, Boonserm P. The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins. BMC Struct Biol. 2015;15:17 pubmed publisher
    ..structural changes upon peptide binding could be predicted based on the comparison with the closely-related JNK3 structure in complex with pepJIP1...
  26. Petrov D, Luque M, Pedrós I, Ettcheto M, Abad S, Pallas M, et al. Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease. Mol Neurobiol. 2016;53:6183-6193 pubmed publisher
    ..JNK subfamily is encoded by three separate but related genes: jnk1, jnk2, and jnk3, giving rise to at least ten distinct splice variants of the JNK proteins...
  27. Ansideri F, Lange A, El Gokha A, Boeckler F, Koch P. Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase. Anal Biochem. 2016;503:28-40 pubmed publisher
    ..as probes for the binding affinity determination of potential kinase inhibitors to the c-Jun N-terminal kinase 3 (JNK3) and p38α mitogen-activated protein kinase (MAPK)...
  28. Schriemer D, Sribudiani Y, IJpma A, Natarajan D, MacKenzie K, Metzger M, et al. Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes. Dev Biol. 2016;416:255-265 pubmed publisher
    ..regulators of gene expression in ENCCs include the known HSCR genes Ret and Sox10, as well as Bdnf, App and Mapk10. The regulatory overlap and functional interactions between these genes were used to construct a regulatory ..
  29. Sarin N, Engel F, Rothweiler F, Cinatl J, Michaelis M, Frötschl R, et al. Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. Int J Mol Sci. 2018;19: pubmed publisher
    ..HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and ..
  30. Mishra P, Günther S. New insights into the structural dynamics of the kinase JNK3. Sci Rep. 2018;8:9435 pubmed publisher
    ..the energetics of the all-atom structure of a neuronal-specific serine/threonine kinase c-Jun N-terminal kinase 3 (JNK3) in three states: unphosphorylated, phosphorylated, and ATP-bound phosphorylated...
  31. Solinas G, Becattini B. JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab. 2017;6:174-184 pubmed publisher
    ..evidence indicates that whereas JNK1 and JNK2 isoforms promote the development of obesity and insulin resistance, JNK3 activity protects from excessive adiposity...
  32. Green A, Vasu S, McClenaghan N, Flatt P. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Arch. 2015;467:2219-28 pubmed publisher
    ..upregulated in pseudoislets compared to monolayers, whilst the expression of proapoptotic genes (NOS2, MAPK8, MAPK10 and NFKB1) showed no significant differences...
  33. Muzyka V, Brooks M, Badea T. Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells. Neural Dev. 2018;13:15 pubmed publisher
    ..Only three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4.
  34. Gong J, Sun F, Li Y, Zhou X, Duan Z, Duan F, et al. Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway. Neuropharmacology. 2015;91:123-34 pubmed publisher
    ..superoxide (O2(-)), nitric oxide (NO) and peroxynitrite (ONOO(-)) and inhibiting c-Jun N-terminal protein kinase (JNK3) signaling cascades...
  35. Zhu Q, Kong F, Xu H, Wang Y, Du C, Sun C, et al. Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia. Proc Natl Acad Sci U S A. 2014;111:13990-5 pubmed publisher
    ..In addition, GluK2 phosphorylation at Y590 facilitates the endocytosis of GluK2 subunits, and the activation of JNK3 and its substrate c-Jun after long-term kainate treatment...
  36. Chakraborty S, Srivastava A, Jha M, Nair A, Pandey S, Srivastava N, et al. Inhibition of CD40-induced N-Ras activation reduces leishmania major infection. J Immunol. 2015;194:3852-60 pubmed publisher
    ..major-expressed MAPK10 enhanced MAPK10-specific Th1-type response. CD40-deficient mice primed with these macrophages had reduced L...
  37. Heanue T, Boesmans W, Bell D, Kawakami K, Vanden Berghe P, Pachnis V. A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. PLoS Genet. 2016;12:e1006439 pubmed publisher
    ..We generated mapk10 loss-of-function mutants, which show reduced numbers of enteric neurons...
  38. Barreto S, González Vázquez A, Cameron A, Cavanagh B, Murray D, O Brien F. Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis. Acta Biomater. 2017;53:59-69 pubmed publisher
    ..an age-dependent, stiffness-induced upregulation of NOX1, VEGFR1, VEGFR2, WIF1 and, of particular interest, JNK3 in cells from children compared to adults...
  39. Yuill M, Zee M, Marcus D, Morgan D. Tolerance to the antinociceptive and hypothermic effects of morphine is mediated by multiple isoforms of c-Jun N-terminal kinase. Neuroreport. 2016;27:392-6 pubmed publisher
    ..was assessed in wild-type mice and compared with single knockout mice each lacking the JNK isoforms (JNK1, JNK2, or JNK3)...
  40. Zhan X, Stoy H, Kaoud T, Perry N, Chen Q, Perez A, et al. Peptide mini-scaffold facilitates JNK3 activation in cells. Sci Rep. 2016;6:21025 pubmed publisher
    ..facilitates JNK activation in cells, and a short 25-residue arrestin-3 peptide was identified as the critical JNK3-binding element...
  41. Yoshida S, Fukino K, Harada H, Nagai H, Imoto I, Inazawa J, et al. The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors. J Hum Genet. 2001;46:182-7 pubmed
    ..In the present study, genomic cloning revealed that the JNK3 gene consists of 14 exons interrupted by 13 introns; its transcription-initiation site is within exon 3 and the ..
  42. Guo C, Whitmarsh A. The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus. J Biol Chem. 2008;283:15903-11 pubmed publisher
    ..beta-Arrestin-2 acts as a scaffold by directly binding to the JNK3 isoform and also by recruiting MKK4 and the MAPKKK apoptosis-signaling kinase-1 (ASK1)...
  43. Choi W, Kim H, Xia Z. JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. Toxicology. 2015;328:75-81 pubmed publisher
    ..Here we report that the neural specific JNK3 isoform of the JNKs, but not JNK1 or JNK2, is responsible for this neuron death in primary cultured dopamine ..
  44. Hurvitz S, Kalous O, Conklin D, Desai A, Dering J, Anderson L, et al. In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response. Breast Cancer Res Treat. 2015;149:669-80 pubmed publisher
    ..Transcript expression microarrays identified GSK3A, PIK3R3, KLF8, and MAPK10 among the genes overexpressed in sensitive luminal lines, while PGP, RPL38, GPT, and GFAP were among the genes ..
  45. Muthaiah V, Michael F, Palaniappan T, Rajan S, Chandrasekar K, Venkatachalam S. JNK1 and JNK3 play a significant role in both neuronal apoptosis and necrosis. Evaluation based on in vitro approach using tert-butylhydroperoxide induced oxidative stress in neuro-2A cells and perturbation through 3-aminobenzamide. Toxicol In Vitro. 2017;41:168-178 pubmed publisher
    ..By perturbing the progress of necrosis using 3-amniobenzamide, a known PARP1 inhibitor, it was found that JNK1 and JNK3 but not JNK2 were involved in pre-mitochondrial stages of PARP1 mediated cell death...
  46. Ansideri F, Dammann M, Boeckler F, Koch P. Fluorescence polarization-based competition binding assay for c-Jun N-terminal kinases 1 and 2. Anal Biochem. 2017;532:26-28 pubmed publisher
    ..kinase (JNK) family, a fluorescence polarization-based competition binding assay, previously developed for JNK3, was extended to the other isoforms JNK1 and JNK2...
  47. Wu Y, Honegger A, Batyuk A, Mittl P, Plückthun A. Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions. J Mol Biol. 2018;430:2128-2138 pubmed publisher
    ..Because of the high similarity between JNK1, JNK2 and JNK3, it is very difficult to generate small-molecule inhibitors with this discriminatory power...
  48. Saha S, Sadhukhan P, Mahalanobish S, Dutta S, Sil P. Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades. J Nutr Biochem. 2018;55:26-40 pubmed publisher
    ..of arsenic was investigated and revealed that genistein exhibited neuroprotection significantly by modulating the JNK3 mediated apoptosis, ERK1/2 mediated autophagy and TNFα associated inflammatory pathways...
  49. Del Corno M, Liu Q, Schols D, De Clercq E, Gessani S, Freedman B, et al. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood. 2001;98:2909-16 pubmed
    ..HIV-1 Env signaling through these pathways may contribute to dysregulation of uninfected macrophage functions, new target cell recruitment, or modulation of macrophage infection. ..
  50. Chen W, Yeap Y, Bogoyevitch M. The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues. Biochem Biophys Res Commun. 2014;453:576-81 pubmed publisher
    ..The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence...
  51. Chintala S, Putris N, Geno M. Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3. Invest Ophthalmol Vis Sci. 2015;56:505-14 pubmed publisher
    ..the degeneration of retinal ganglion cells (RGCs) by upregulating the protein levels of c-jun N-terminal kinase 3 (JNK3)...
  52. Shao S, Xu M, Zhou J, Ge X, Chen G, Guo L, et al. Atorvastatin Attenuates Ischemia/Reperfusion-Induced Hippocampal Neurons Injury Via Akt-nNOS-JNK Signaling Pathway. Cell Mol Neurobiol. 2017;37:753-762 pubmed publisher
    ..ATV could increase the phosphorylation of protein kinase B (Akt1) and nNOS, diminished the phosphorylation of JNK3 and c-Jun, and further inhibited the activation of caspase-3...
  53. Ge X, Zhu G, Geng D, Zhang H, He J, Guo A, et al. Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats. Physiol Behav. 2017;170:115-123 pubmed publisher
    ..damage induced by cerebral I/R and to explore whether the Akt-mediated down-regulation of the phosphorylation of JNK3 signaling pathway contributed to the protection provided by metformin...
  54. Wang S, Zhang T, Yang Z, Lin J, Cai B, Ke Q, et al. Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling. Apoptosis. 2017;22:449-462 pubmed publisher
    ..In current study we examined the role of heme oxygenase-1 (HO-1) in the modulation of MLK3/MKK7/JNK3 signaling, which is a pro-apoptotic pathway, after treating primary spinal cord neurons with H2O2
  55. Choi B, Choi H, Ko K, Cho Y, Zhu F, Kang B, et al. The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat Struct Mol Biol. 2005;12:699-707 pubmed
    ..activity of c-Jun N-terminal kinases (JNKs) and that it binds to the glycine-rich loop of the N-terminal domain of JNK3. Although p16(INK4a) does not affect the phosphorylation of JNKs, its interaction with JNK inhibits c-Jun ..
  56. Song X, Coffa S, Fu H, Gurevich V. How does arrestin assemble MAPKs into a signaling complex?. J Biol Chem. 2009;284:685-95 pubmed publisher
    ..Here we have demonstrated that all four vertebrate arrestins interact with JNK3, MKK4, and ASK1, but only arrestin3 facilitates JNK3 activation...
  57. Neidhart S, Antonsson B, Gillieron C, Vilbois F, Grenningloh G, Arkinstall S. c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10. FEBS Lett. 2001;508:259-64 pubmed
    ..Moreover, SCG10 was found to bind tightly and specifically to JNK3/SAPKbeta...
  58. Antoniou X, Falconi M, Di Marino D, Borsello T. JNK3 as a therapeutic target for neurodegenerative diseases. J Alzheimers Dis. 2011;24:633-42 pubmed publisher
    c-Jun N-terminal kinases (JNKs) and in particular JNK3 the neuronal specific isoform, have been recognized as important enzymes in the pathology of diverse neurological disorders...
  59. Gourmaud S, Paquet C, Dumurgier J, Pace C, Bouras C, Gray F, et al. Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline. J Psychiatry Neurosci. 2015;40:151-61 pubmed
    ..The biochemical and morphological results showed a significant increase of JNK3 and phosphorylated JNK levels in patients with Alzheimer disease, and JNK3 levels correlated with Aβ42 levels...
  60. Li S, Wang X, Ma Q, Yang W, Zhang X, Dawe G, et al. Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. Sci Rep. 2016;6:39320 pubmed publisher
    ..sodium channels in the white matter of spinal cord and the spinal conduction velocity is decreased in APP, p35 and JNK3 knockout mice. Therefore, APP modulates Nav1...
  61. Cheng Y, Zhang X, Sun Y, Wang W, Huang J, Chu N, et al. Genomewide DNA Methylation Responses in Patients with ?-Thalassemia Treated with Yisui Shengxue Granules (). Chin J Integr Med. 2018;: pubmed publisher
    ..5-bisphosphate phosphodiesterase gamma 2 (PLCG2) and mitogen-activated protein kinase 10 (MAPK10) showed a stronger intermediary role (betweenness centrality=0.04)...
  62. Cuny G. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Curr Pharm Des. 2009;15:3919-39 pubmed
    ..Then, the role of several kinase (i.e. JNK3, p38 MAPK, ERK, PKC, ROCKII, GSK3, Cdk5, MLK, EphB3 kinase, RIP1 kinase, LRRK2, TTBK1, ASK1, CK, DAPK, and PKN1) ..
  63. Kong L, Wang B, Yuan R, Jia M, Wang K. [Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones]. Shanghai Kou Qiang Yi Xue. 2015;24:89-93 pubmed
    ..oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated. There are abnormal expressions of genes of Wnt pathway in KCOT...
  64. Sido A, Radhakrishnan S, Kim S, Eriksson E, Shen F, Li Q, et al. A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. J Nutr Biochem. 2017;43:11-17 pubmed publisher
    ..Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1α, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2). Furthermore, these proteins also correlated with Ki-67 proliferative index/zone...
  65. Harder J, Williams P, Soto I, Foxworth N, Fernandes K, Freeburg N, et al. Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice. Cell Death Dis. 2018;9:705 pubmed publisher
    The cJun N-terminal kinases (JNKs; JNK1, JNK2, and JNK3) promote degenerative processes after neuronal injury and in disease. JNK2 and JNK3 have been shown to promote retinal ganglion cell (RGC) death after optic nerve injury...
  66. Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, et al. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. J Biol Chem. 2002;277:40703-9 pubmed
    ..JSAP1 in vitro and in vivo, and the phosphorylation facilitated interactions of JSAP1 with SEK1/MKK4, MKK7 and JNK3. Furthermore, ASK1-dependent phosphorylation was required for JSAP1 to recruit and thereby activate JNK in response ..
  67. Guo M, Wei J, Zhou Y, Qin Q. c-Jun N-terminal kinases 3 (JNK3) from orange-spotted grouper, Epinephelus coioides, inhibiting the replication of Singapore grouper iridovirus (SGIV) and SGIV-induced apoptosis. Dev Comp Immunol. 2016;65:169-181 pubmed publisher
    ..b>JNK3 is one of JNK proteins involved in JNK3 signaling transduction...
  68. Yao K, Cho Y, Bode A, Vummenthala A, Park J, Liu K, et al. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 2009;583:2208-12 pubmed publisher
    ..that 7-(6-N-phenylaminohexyl)amino-2H-anthra[1,9-cd]pyrazol-6-one (AV-7) inhibited JNK1 activity, but not JNK2 or JNK3. We found that ultraviolet B (UVB) induced c-Jun phosphorylation and sub-G1 accumulation in JNK2(-/-) murine ..
  69. Vernia S, Morel C, Madara J, Cavanagh Kyros J, Barrett T, Chase K, et al. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. elife. 2016;5:e10031 pubmed publisher
    ..However, the role of the neuron-specific isoform JNK3 is unclear. Here we demonstrate that JNK3 deficiency causes hyperphagia selectively in high fat diet (HFD)-fed mice...
  70. He P, Zhang B, Liu D, Bian X, Li D, Wang Y, et al. Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway. Cell Physiol Biochem. 2016;39:1433-43 pubmed publisher
    ..1(+)-HBx group when treated with K252a, a known inhibitor of MLK3. Our results show that HBx induces apoptosis in NRK-52E cells and activates Fas/FasL via the MLK3-MKK7-JNK3-c-Jun signaling pathway.
  71. Kuhar J, Bedini A, Melief E, Chiu Y, Striegel H, Chavkin C. Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms. Cell Signal. 2015;27:1799-806 pubmed publisher
    ..We compared JNK activation by morphine and fentanyl in JNK1(-/-), JNK2(-/-), JNK3(-/-), and GRK3(-/-) mice and found that both compounds specifically activate JNK2 in vivo; however, fentanyl ..
  72. Muth F, Günther M, Bauer S, Döring E, Fischer S, Maier J, et al. Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases. J Med Chem. 2015;58:443-56 pubmed publisher
    ..of 45 derivatives was prepared and evaluated in a kinase activity assay for their ability to inhibit both kinases, JNK3 and p38α MAP kinase...
  73. Wang Z, Zhou Y, Luo Y, Zhang J, Zhai Y, Yang D, et al. Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice. Int J Mol Sci. 2015;16:28320-33 pubmed publisher
    ..Hinfp, Gadd45b, and Tet3 were significantly up-regulated, while Olfr370, Olfr1414, Olfr1208, Golf, Faim2, Tsg101, Mapk10, Actl6b, H2BE, ATF5, Kirrrel2, OMP, Drd2 etc. were significantly down-regulated...
  74. de Lemos L, Junyent F, Camins A, Castro Torres R, Folch J, Olloquequi J, et al. Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms. Mol Neurobiol. 2018;55:4437-4452 pubmed publisher
    ..The aim of the present study was to identify the role of the different JNK isoforms (JNK1, JNK2, and JNK3) in apoptosis and inflammation after induction of brain damage...
  75. Putcha G, Le S, Frank S, Besirli C, Clark K, Chu B, et al. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron. 2003;38:899-914 pubmed
    ..Thus, JNKs regulate the proapoptotic activity of BIM(EL) during TFD, both transcriptionally and posttranslationally. ..
  76. Bukhari H, Kolbe K, Leonhardt G, Loosse C, Schröder E, Knauer S, et al. Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation. Cell Signal. 2016;28:1725-34 pubmed publisher
    ..In this study, we demonstrate that membrane-tethered C99 is phosphorylated by JNK3A at residue T668 (APP695 numbering) to a higher extent than AICD57, whereas AICD50 is not capable of being ..
  77. Wiltshire C, Matsushita M, Tsukada S, Gillespie D, May G. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. Biochem J. 2002;367:577-85 pubmed
    ..These and previously reported properties of Sab suggest a possible role in targeting JNK to this subcellular compartment and/or mediating cross-talk between the Btk and JNK signal transduction pathways. ..
  78. Zhan X, Kaoud T, Dalby K, Gurevich V. Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3?2 signaling complex. Biochemistry. 2011;50:10520-9 pubmed publisher
    ..Although arrestins were reported to serve as scaffolds for MAP kinase cascades, promoting the activation of JNK3, ERK1/2, and p38, the molecular mechanisms involved were not elucidated, and even the direct binding of arrestins ..
  79. Pandareesh M, Shrivash M, Naveen Kumar H, Misra K, Srinivas Bharath M. Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson's Disease. Neurochem Res. 2016;41:3113-3128 pubmed
    ..CMG induced anti-apoptotic effects was substantiated by decreased phosporylation of JNK3 and c-jun, which in turn decreased the cleavage of pro-caspase 3...
  80. Kolbe K, Bukhari H, Loosse C, Leonhardt G, Glotzbach A, Pawlas M, et al. Extensive nuclear sphere generation in the human Alzheimer's brain. Neurobiol Aging. 2016;48:103-113 pubmed publisher
    ..Cell culture experiments revealed that JNK3-mediated APP phosphorylation reduces the amount of sphere-positive cells...
  81. Habelhah H, Shah K, Huang L, Ostareck Lederer A, Burlingame A, Shokat K, et al. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol. 2001;3:325-30 pubmed
    ..Our results establish the role of MAPK/ERK in phosphorylation-dependent cellular localization of hnRNP-K, which is required for its ability to silence mRNA translation. ..
  82. Kich D, Bitencourt S, Alves C, Silva J, Pinteus S, Pedrosa R, et al. Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Biomed Pharmacother. 2016;84:382-386 pubmed publisher
    ..the potential of the extracts to inhibit the neurodegenerative-related enzymes c-Jun N-terminal kinase 3 (JNK3) and acetylcholinesterase (AChE)...
  83. Valori M, Jansson L, Kiviharju A, Ellonen P, Rajala H, Awad S, et al. A novel class of somatic mutations in blood detected preferentially in CD8+ cells. Clin Immunol. 2017;175:75-81 pubmed publisher
    ..were in genes that may play a role in autoimmunity (ATM, BTK, CD46, CD180, CLIP2, HMMR, IKFZF3, ITGB3, KIR3DL2, MAPK10, CD56/NCAM1, RBM6, RORA, RPA1 and STAT3)...
  84. Amengual J, Prabhu S, Lombardo M, Zullo K, Johannet P, Gonzalez Y, et al. Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib. Clin Cancer Res. 2017;23:3084-3096 pubmed publisher
    ..GEP revealed upregulation of MAPK10, HELIOS, HDAC9, and FYN, as well as downregulation of SH3BP5 and LCK...
  85. Cheng Y, Yan Y, Lundy D, Lo A, Wang Y, Ruan S, et al. Reprogramming-derived gene cocktail increases cardiomyocyte proliferation for heart regeneration. EMBO Mol Med. 2017;9:251-264 pubmed publisher
    ..Delivering a cocktail of three genes, FoxM1, Id1, and Jnk3-shRNA (FIJs), induced CMs to re-enter the cell cycle and complete mitosis and cytokinesis in vitro More ..
  86. Abd El Aal S, Abd El Fattah M, El Abhar H. CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-?B/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues. Front Pharmacol. 2017;8:735 pubmed publisher
    ..Additionally, both treatments downregulate the JNK3/c-Jun signaling pathway. The effect of the combination regimen overrides that of either treatment alone...
  87. Busquets O, Ettcheto M, Verdaguer E, Castro Torres R, Auladell C, Beas Zarate C, et al. JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid. Neuropharmacology. 2018;131:440-452 pubmed publisher
    ..of the JNK1 gene has neuroprotective effects against the damage induced by KA, as it occurs with the absence of JNK3. The aim of the present study was to analyse whether the pharmacological inhibition of JNK1 by Licochalcone A (Lic-..
  88. Luo M, Chen M, Stoiber H, Dierich M. Activation of mitogen activated protein kinases via complement receptor type 2. Chin Med J (Engl). 2004;117:1802-8 pubmed
    ..The results of the signal transduction and cell proliferation assays of HOS-CD4CR2 cells show that CR2 plays a role in the pathogenesis of HIV infection, especially in the inhibition of CD4+ cell proliferation. ..
  89. Genabai N, Ahmad S, Zhang Z, Jiang X, Gabaldon C, Gangwani L. Genetic inhibition of JNK3 ameliorates spinal muscular atrophy. Hum Mol Genet. 2015;24:6986-7004 pubmed publisher
    ..The neuron-specific isoform JNK3 is required for neuron degeneration caused by SMN deficiency...
  90. Katari S, Natarajan P, Swargam S, Kanipakam H, Pasala C, Umamaheswari A. Inhibitor design against JNK1 through e-pharmacophore modeling docking and molecular dynamics simulations. J Recept Signal Transduct Res. 2016;36:558-571 pubmed
    ..JNKs) come under a class of serine/threonine protein kinases and are encoded by three genes, namely JNK1, JNK2 and JNK3. Human JNK1 is a cytosolic kinase belonging to mitogen-activated protein kinase (MAPK) family, which plays a major ..
  91. Chintala S, Daram N. Down-Regulation of RNA 3'-Terminal Phosphate Cyclase Attenuates Toll-Like Receptor 3-Mediated Axonal Loss in the Retina and Optic Nerve. Invest Ophthalmol Vis Sci. 2016;57:5338-5347 pubmed publisher
    ..Western blot assays were performed to determine TLR3, Rtca, c-jun N-terminal kinase 3 (JNK3), and phospho-JNK3 (pJNK3) levels, and immunohistochemistry assays were performed to determine the cells that ..
  92. Wang H, Engstrom A, Xia Z. Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases. Toxicology. 2017;380:30-37 pubmed publisher
    ..did not cause cell loss or apoptosis in SVZ-aNPCs prepared from transgenic mice null for the neural-specific JNK3 isoform. These data suggest a critical role for p38 and JNK3 MAP kinases in Cd neurotoxicity...