MAP3K8

Summary

Gene Symbol: MAP3K8
Description: mitogen-activated protein kinase kinase kinase 8
Alias: COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, Ewing sarcoma transformant, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2
Species: human

Top Publications

  1. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
  2. doi IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2
    Hosea Handoyo
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 424:109-18. 2009
  3. doi TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
  4. ncbi TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
    M P Belich
    Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, UK
    Nature 397:363-8. 1999
  5. pmc Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity
    Hong Seok Choi
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    FASEB J 22:113-26. 2008
  6. ncbi Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
    J Perry Hall
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:33295-304. 2007
  7. pmc Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
    J Miyoshi
    Department of Oncogene Research, Osaka University, Japan
    Mol Cell Biol 11:4088-96. 1991
  8. pmc Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
    Lawrence P Kane
    Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:5962-74. 2002
  9. ncbi Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner
    A Ballester
    Instituto de Investigaciones Biomedicas, CSIC, Facultad Medicina Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 273:14099-106. 1998
  10. pmc Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation
    M Chiariello
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 20:1747-58. 2000

Research Grants

  1. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
  2. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew Greenberg; Fiscal Year: 2009
  3. Tpl2 in Intestinal Tumorigenesis
    Philip N Tsichlis; Fiscal Year: 2010
  4. International Conference on Tobacco Induced Diseases
    Denis Kinane; Fiscal Year: 2004
  5. Regulation of the Tp12 Kinase
    Philip Tsichlis; Fiscal Year: 2009
  6. ROLE OF TPL-2, CYCLIN D1 AND TOUVLO IN BREAST CANCER
    Christos Patriotis; Fiscal Year: 2002
  7. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
  8. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2007
  9. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2010
  10. ROLE OF TVI 1 IN APOPTOSIS
    Philip Tsichlis; Fiscal Year: 2004

Detail Information

Publications165 found, 100 shown here

  1. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
    ..Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1...
  2. doi IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2
    Hosea Handoyo
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 424:109-18. 2009
    The protein kinase Tpl2 (tumour progression locus 2) is activated by LPS (lipopolysaccharide), TNFalpha (tumour necrosis factor alpha) and IL (interleukin)-1...
  3. doi TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
    Activation of the TPL2-MKK1/2-ERK1/2 signalling pathway is essential for lipopolysaccharide (LPS)-stimulated production of TNF alpha in macrophages...
  4. ncbi TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
    M P Belich
    Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, UK
    Nature 397:363-8. 1999
    ..a carboxy-terminal-deleted form, as an oncoprotein in rats and is more than 90% identical to the human oncoprotein COT. Expression of TPL-2 results in phosphorylation and increased degradation of p105 while maintaining p50 production...
  5. pmc Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity
    Hong Seok Choi
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    FASEB J 22:113-26. 2008
    ..The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family...
  6. ncbi Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
    J Perry Hall
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:33295-304. 2007
    ..b>Tpl2 is a MAPKKK in the MAPK (i.e...
  7. pmc Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
    J Miyoshi
    Department of Oncogene Research, Osaka University, Japan
    Mol Cell Biol 11:4088-96. 1991
    ..from hamster SHOK cells transformed with DNA extracted from a human thyroid carcinoma cell line and named the cot (cancer Osaka thyroid) oncogene...
  8. pmc Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
    Lawrence P Kane
    Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:5962-74. 2002
    The Akt (or protein kinase B) and Cot (or Tpl-2) serine/threonine kinases are associated with cellular transformation. These kinases have also been implicated in the induction of NF-kappa B-dependent transcription...
  9. ncbi Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner
    A Ballester
    Instituto de Investigaciones Biomedicas, CSIC, Facultad Medicina Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 273:14099-106. 1998
    b>Cot kinase is a protein serine/threonine kinase, classified as a mitogen-activated protein kinase kinase kinase, implicated in T lymphocyte activation...
  10. pmc Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation
    M Chiariello
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 20:1747-58. 2000
    The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family implicated in cellular transformation...
  11. ncbi Cot kinase regulation of IL-2 production in Jurkat T cells
    A Ballester
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina Universidad Autonoma de Madrid, Spain
    J Immunol 159:1613-8. 1997
    ..b>cot is a very closely related gene, if not the human homologue...
  12. ncbi The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
    M Aoki
    Department of Oncogene Research, Osaka University, Japan
    J Biol Chem 268:22723-32. 1993
    The cot gene is an oncogene encoding serine/threonine kinases isolated by DNA transfection assay...
  13. pmc The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2
    Aristides G Eliopoulos
    The Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 76:4567-79. 2002
    ..In this study, we have identified the oncogenic kinase Tpl-2/Cot as a novel component of LMP1-induced NF-kappaB signaling...
  14. doi Evaluation of the phototoxic potential of plants used in oriental medicine
    Ki Min Bark
    Department of Chemical Education and Research Institute of Life Science, Gyeongsang National University, Jinju, 660 701, South Korea
    J Ethnopharmacol 127:11-8. 2010
    ..Phototoxicity can be either harmful or beneficial. Yet the phototoxicity of oriental medicinal plants is an understudied area. The purpose of this study is to fill in this gap...
  15. ncbi Effect of a sudden infant death syndrome risk reduction education program on risk factor compliance and information sources in primarily black urban communities
    Kenneth A Rasinski
    National Opinion Research Center at the University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 111:e347-54. 2003
    ..The continued racial disparity in SIDS is thought to be attributable to lack of compliance with SIDS risk reduction recommendations...
  16. ncbi Transposon tagging and the study of root development in Arabidopsis
    R Tsugeki
    Biotechnology Institute, The Pennsylvania State University, University Park, USA
    Gravit Space Biol Bull 11:79-87. 1998
    ..A gene expressed in root cap cells tagged with an enhancer-trap Ds was isolated and its corresponding EST cDNA was identified...
  17. ncbi Marine bacteria comprise a possible indicator of drowning in seawater
    Eiji Kakizaki
    Section of Legal Medicine, Department of Social Medicine, Faculty of Medicine Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Forensic Sci Int 176:236-47. 2008
    ..Blue colonies stained using the cytochrome oxidase test (COT), were detected in blood mixed with both sea and river water...
  18. ncbi Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Vejle, Denmark
    Thromb Res 98:233-9. 2000
    Sudden infant death syndrome or "cot death" has until the late eighties been a significant cause of death in children between the ages of 1 month and 1 year...
  19. ncbi Skin-to-skin care with the father after cesarean birth and its effect on newborn crying and prefeeding behavior
    Kerstin Erlandsson
    Department of Woman and Child Health, Division of Reproductive and Perinatal Health, Karolinska Institutet, Stockholm, Sweden
    Birth 34:105-14. 2007
    ..of skin-to-skin contact on crying and prefeeding behavior in healthy, full-term infants born by elective cesarean birth and cared for skin-to-skin with their fathers versus conventional care in a cot during the first 2 hours after birth.
  20. pmc Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    J Lingner
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Proc Natl Acad Sci U S A 94:11190-5. 1997
    ..Previous characterization of yeast telomerase function in vivo identified four EST (for ever shorter telomeres) genes that, when mutated, result in the phenotypes expected for a defect in telomerase...
  21. ncbi Regulation of K-Cl cotransport: from function to genes
    N C Adragna
    Department of Pharmacology, Wright State University, School of Medicine, Dayton, OH 45435 0002, USA
    J Membr Biol 201:109-37. 2004
    This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation from a functional and genetic viewpoint...
  22. ncbi Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
    Katie J Loniewski
    Division of Pathology, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 44:3715-23. 2007
    ..7, a mouse macrophage cell line. ERK activation in macrophages by TLR4 and -7 is mediated via a MAP3K, called TPL2/COT, which under unstimulated conditions is associated with NF kappa B1 p105, a member of the I kappa B family of ..
  23. ncbi Circadian rhythms and enhanced athletic performance in the National Football League
    R S Smith
    Stanford University Sleep Disorders Clinic, CA 94305, USA
    Sleep 20:362-5. 1997
    ..m. Eastern Standard Time (EST) from the 1970-1994 seasons...
  24. pmc Characterization of cotJ, a sigma E-controlled operon affecting the polypeptide composition of the coat of Bacillus subtilis spores
    A O Henriques
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Bacteriol 177:3394-406. 1995
    ..Studies with double-reporter strains bearing a cotJ-gusA fusion and lacZ fusions to other cot genes confirmed that expression of cotJ is initiated during sporulation prior to activation of genes known to ..
  25. ncbi Treatment patterns in elderly patients (greater than or equal to 70 years) with breast carcinoma. A retrospective study of the Gruppo Oncologico Clinico Cooperativo del nord-Est (GOCCNE)
    D Crivellari
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 77:136-40. 1991
    ..Comorbid conditions are of particular concern in therapy planning, considering that more stage III patients died of competing causes than for disease progression. The role of chemotherapy was very marginal...
  26. ncbi Strategies to improve photostabilities in ultrasensitive fluorescence spectroscopy
    Jerker Widengren
    Experimental Biomolecular Physics, Department of Applied Physics, AlbaNova University Center, Royal Institute of Technology, SE 10691 Stockholm, Sweden
    J Phys Chem A 111:429-40. 2007
    ..gallate, nPG, ascorbic acid, AA) and triplet state quenchers (mercaptoethylamine, MEA, cyclo-octatetraene, COT), were investigated, and the relevant rate parameters involved were determined for the dye Rhodamine 6G...
  27. doi Practice variation in the transfer of premature infants from incubators to open cots in Australian and New Zealand neonatal nurseries: results of an electronic survey
    Karen New
    The University of Queensland, School of Nursing and Midwifery, Royal Brisbane and Women s Hospital, Butterfield Street, Brisbane, Queensland 4029, Australia
    Int J Nurs Stud 47:678-87. 2010
    ..of the premature infant but the infant is ultimately required to make a successful transfer from incubator to open cot in order to be discharged from hospital...
  28. doi The beginnings of modern psychiatric treatment in Europe. Lessons from an early account of convulsive therapy
    Brigitta Baran
    Dept of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Eur Arch Psychiatry Clin Neurosci 258:434-40. 2008
    Convulsive therapy (COT) is a major European contribution to the psychiatric armamentarium and biological psychiatry. COT was introduced in psychiatry by László Meduna, a Hungarian neuropsychiatrist...
  29. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI...
  30. pmc Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion
    A Makris
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 67:4283-9. 1993
    ..Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity...
  31. ncbi Who's got what? A benchmarking exercise for tertiary neonatal units
    C A Kuschel
    Newborn Services, National Women s Health, Auckland District Health Board, Auckland, New Zealand
    J Paediatr Child Health 41:635-9. 2005
    ..Background: Many current NNU in Australia and New Zealand are planning new or redesigning existing facilities. There are no adequate local standards for NNU design available which reflect changing neonatal practices...
  32. ncbi Antibiotic resistance of Salmonella enterica serovar Paratyphi A in India: emerging and reemerging problem
    Shyamapada Mandal
    Department of Bacteriology and Serology, Calcutta School of Tropical Medicine, C R Avenue, Kolkata 700073, India
    J Postgrad Med 52:163-6. 2006
    ..Antibiotic resistance pattern and R-plasmid of Salmonella enterica serovar Paratyphi A isolates from Kolkata, India are not well documented...
  33. pmc The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors
    K H Ruan
    Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
    Biochem J 274:849-54. 1991
    ..electric ray) and human acetylcholine receptors (AChR) were localized by reaction of 125I-labelled cobrotoxin (Cot) and erabutoxin b (Eb) with synthetic overlapping peptides spanning the entire extracellular part of the respective ..
  34. doi Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone
    Emirhan Nemutlu
    Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Sihhiye, Ankara, Turkey
    Talanta 80:117-26. 2009
    ..of seven cephalosporins [Cefepime (CEP), ceftazidime (CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and cefoperazone (COP)] in human plasma and amniotic fluid has been developed...
  35. pmc Reducing medication errors in the neonatal intensive care unit
    J H Simpson
    Paediatric Department, Princess Royal Maternity Hospital, Glasgow G31 2ER, Scotland, UK
    Arch Dis Child Fetal Neonatal Ed 89:F480-2. 2004
    ..Medication errors are common in the neonatal intensive care unit (NICU). Various strategies to reduce errors have been described in adult and paediatric patients but there are few published data on their effect in the NICU...
  36. ncbi High-performance liquid chromatographic assay for N-glucuronidation of nicotine and cotinine in human liver microsomes
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa, 920 0934, Japan
    Anal Biochem 302:131-5. 2002
    ..The nicotine N-glucuronide (Nic-glu) and cotinine N-glucuronide (Cot-glu) formed were analyzed by ion-pair chromatography with a C-18 column...
  37. pmc Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
    T Kato
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Glia 30:209-18. 2000
    ..Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1-positive cells and OEC nuclei within the repaired lesion...
  38. ncbi Occurrence of Escherichia coli O157 in raw material and food in Czech Republic
    J Lukásová
    Department of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, The Czech Republic
    J Vet Med B Infect Dis Vet Public Health 51:77-81. 2004
    ..GEN), colistin (COL), cephalozine (CLZ), cefoxitin (CXT), aztreonam (AZT), and sulphamethoxazole + trimethoprim (COT) was tested using the standard dilution technique and disc diffusion test...
  39. pmc The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassa
    Sabine Maerz
    Institut für Mikrobiologie und Genetik Abteilung Molekulare Mikrobiologie, Universitat Gottingen, D 37077 Gottingen, Germany
    Genetics 179:1313-25. 2008
    ..Here, we identify the cot-1 suppressor gul-4 as mak-2 and show that mutants of the gul-4/mak-2 mitogen-activated protein (MAP) kinase pathway ..
  40. doi Perforating globe injuries during operation Iraqi Freedom
    Marcus H Colyer
    Ophthalmology Service, Walter Reed Army Medical Center, Washington, DC, USA
    Ophthalmology 115:2087-93. 2008
    ..with perforating (through-and-through) injuries of the globe and the visual impact of these injuries on patients with combat ocular trauma (COT) seen at Walter Reed Army Medical Center (WRAMC) from March 2003 through October 2006.
  41. pmc BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes
    Valeriu B Cismasiu
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, U S A
    Biochem J 417:457-66. 2009
    ..of IkappaB kinase in the TCR/CD28 signalling pathway was affected by increased BCL11B expression, and found that Cot (cancer Osaka thyroid oncogene) kinase mRNA levels were elevated...
  42. pmc Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation
    Irene Soria-Castro
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid 28029
    J Biol Chem 285:33805-15. 2010
    Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo...
  43. ncbi Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
    M Morillas
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    J Biol Chem 276:45001-8. 2001
    Carnitine palmitoyltransferase I (CPT I) and carnitine octanoyltransferase (COT) catalyze the conversion of long- and medium-chain acyl-CoA to acylcarnitines in the presence of carnitine...
  44. pmc Characterization of X-chromosome inactivation status in human pluripotent stem cells
    Jennifer A Erwin
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2010
    This unit describes a method of performing fluorescent in situ hybridization (FISH) of XIST and Cot-1 RNA in human pluripotent stem cells (hPSC) to characterize the epigenetic status of X-chromosome inactivation (XCI)...
  45. ncbi Molecular differentiation of sex chromosomes probed by comparative genomic hybridization
    W Traut
    Institut fur Biologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Chromosoma 108:173-80. 1999
    ..simultaneously with FluorX-labelled DNA of females and Cy3-labelled DNA of males in the presence of an excess of Cot-1 DNA or unlabelled DNA of the homogametic sex...
  46. doi Head covering and the risk for SIDS: findings from the New Zealand and German SIDS case-control studies
    Edwin A Mitchell
    University of Auckland, Department of Paediatrics, Private Bag 92019, Auckland, New Zealand
    Pediatrics 121:e1478-83. 2008
    ..By using the data from 2 sudden infant death syndrome case-control studies, consistency of the findings could be assessed...
  47. doi Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placenta
    J M Evoniuk
    Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA
    Placenta 29:422-8. 2008
    ..were collected at day 130, and placentomes were either separated into caruncular (CAR; maternal) or cotyledonary (COT; fetal) placenta and snap-frozen for PrPC mRNA expression or perfusion fixed for PrPC protein expression...
  48. pmc Maintenance treatment of gastroesophageal reflux disease: an evaluation of continuous and on-demand therapy with rabeprazole 20 mg
    D G Morgan
    Division of Gastroenterology, St Joseph s Healthcare, Hamilton, Canada
    Can J Gastroenterol 21:820-6. 2007
    To evaluate continuous therapy (COT) and on-demand therapy (ODT) with rabeprazole 20 mg for maintenance in uninvestigated gastroesophageal reflux disease (GERD).
  49. doi Syntheses and crystal structures of ruthenium and rhodium olefin complexes containing GaCp
    Thomas Cadenbach
    Anorganische Chemie II Organometallics and Materials, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Inorg Chem 48:5021-6. 2009
    ..of the olefin ligands to give [Ru(PPh(3))(2)(GaCp*)(3)] (2), whereas reaction of [Ru(eta(2),eta(2)-COD)(eta(6)-COT)] (COD = 1,5-cyclooctadiene, C(8)H(12), COT = 1,3,5-cyclooctatriene, C(8)H(10)) and GaCp* leads to [Ru(eta(2),eta(2)..
  50. pmc Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family
    J A Zallen
    Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Department of Anatomy and Department of Biochemistry and Biophysics, The University of California, San Francisco, California 94143, USA
    Mol Biol Cell 11:3177-90. 2000
    ..kinase in the Ndr family that is related to the Orb6 (Schizosaccharomyces pombe), Warts/Lats (Drosophila), and COT-1 (Neurospora) kinases that function in cell shape regulation...
  51. pmc Integration of Cot analysis, DNA cloning, and high-throughput sequencing facilitates genome characterization and gene discovery
    Daniel G Peterson
    Center for Applied Genetic Technologies and Department of Crop and Soil Sciences, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 12:795-807. 2002
    b>Cot-based sequence discovery represents a powerful means by which both low-copy and repetitive sequences can be selectively and efficiently fractionated, cloned, and characterized...
  52. ncbi Genes encoding spore coat polypeptides from Bacillus subtilis
    W Donovan
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    J Mol Biol 196:1-10. 1987
    ..To determine the location of the cot genes on the chromosome and to study their function genetically, we tagged each gene by insertion of a ..
  53. ncbi Clothing fabric does not affect thermoregulation during exercise in moderate heat
    T P Gavin
    Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 33:2124-30. 2001
    ..We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics...
  54. ncbi Impact of a conjugate vaccine on community-wide carriage of nonsusceptible Streptococcus pneumoniae in Alaska
    Matthew R Moore
    Division of Applied Public Health Training, Epidemiology Program Office, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Infect Dis 190:2031-8. 2004
    ..Antimicrobial resistance among pneumococci has increased in recent years and complicates treatment. The introduction of heptavalent pneumococcal conjugate vaccine (PCV7) could reduce acquisition of antimicrobial-resistant pneumococci...
  55. ncbi Carnitine acyltransferases are not changed in Alzheimer disease
    I Maurer
    Department of Neurology, , Bonn, Germany
    Alzheimer Dis Assoc Disord 12:71-6. 1998
    We evaluated the activities of carnitine palmitoyltransferase (CPT), carnitine octanoyltransferase (COT), and carnitine acetyltransferase (CAT) in the frontal cortex, temporal cortex, parietal cortex, hippocampus, and cerebellum of ..
  56. ncbi Integrated in silico and biological validation of the blocking effect of Cot-1 DNA on Microarray-CGH
    Seung Hui Kang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Mol Med 19:901-8. 2007
    In array-CGH, various factors may act as variables influencing the result of experiments. Among them, Cot-1 DNA, which has been used as a repetitive sequence-blocking agent, may become an artifact-inducing factor in BAC array-CGH...
  57. ncbi Cryogenic oven-trapping gas chromatography for analysis of volatile organic compounds in body fluids
    K Watanabe-Suzuki
    Department of Legal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Anal Bioanal Chem 373:75-80. 2002
    Cryogenic oven-trapping (COT) with capillary GC has been successfully applied to analysis of chloroform, dichloromethane, trichloroethylene, diethyl ether, the components of solvent thinner (ethyl acetate, benzene, n-butanol, toluene, ..
  58. ncbi Does acupuncture improve the orthopedic management of chronic low back pain--a randomized, blinded, controlled trial with 3 months follow up
    Albrecht F Molsberger
    Orthopedic Surgery and Research, Kasernenstr 1b, 40213, Dusseldorf, Germany
    Pain 99:579-87. 2002
    ..5 years, 0.5-2 years, 2-5 years, >or=5 years. Analysis was by intention to treat. Group 1 (Verum+COT) received 12 treatments of verum acupuncture and conservative orthopedic treatment (COT)...
  59. doi Traumatic brain injury associated with combat ocular trauma
    Eric D Weichel
    Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Ave, Washington, DC 20307, USA
    J Head Trauma Rehabil 24:41-50. 2009
    To determine the impact of traumatic brain injury (TBI) on visual outcomes in combat ocular trauma (COT) and determine the association between TBI severity and types of ocular injuries.
  60. ncbi Inflammatory signaling pathways regulating ApoE gene expression in macrophages
    Anca V Gafencu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    J Biol Chem 282:21776-85. 2007
    ....
  61. pmc Randomised trial of infant sleep location on the postnatal ward
    H L Ball
    Parent Infant Sleep Laboratory and Medical Anthropology Research Group, Department of Anthropology, Durham University, Durham, UK
    Arch Dis Child 91:1005-10. 2006
    ..To determine whether postnatal mother-infant sleep proximity affects breastfeeding initiation and infant safety...
  62. ncbi A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine
    A J Ji
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 45:85-91. 1999
    ..In an attempt to assess THOC and cotinine (COT) concentrations during nicotine transdermal therapy, we developed a new quantitative gas chromatography-mass ..
  63. ncbi The efficacy of noncontact oxygen delivery methods
    Patrick Davies
    Luton and Dunstable NHS Trust, Luton, United Kingdom
    Pediatrics 110:964-7. 2002
    ..We wished to assess the concentration of oxygen delivered to the patient with various methods of "wafting" oxygen...
  64. ncbi Growth and survival of bacteria implicated in sudden infant death syndrome on cot mattress materials
    R O Jenkins
    School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK
    J Appl Microbiol 99:573-9. 2005
    To compare growth and survival of selected bacteria implicated in sudden infant death syndrome (SIDS) on cot mattress polyurethane (PU) inner-foams and on different types of cot mattress cover materials.
  65. pmc Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis
    Jennifer Jager
    Institut National de la Sante et de la Recherche Medicale INSERM, U895, Mediterranean Center of Molecular Medicine, Team 7 Molecular and Cellular Physiopathology of Obesity and Diabetes, Nice, France
    Diabetes 59:61-70. 2010
    ..This study aims at identifying proteins regulating ERK1/2 activity, specifically in response to inflammatory cytokines, to provide new insights into mechanisms leading to abnormal adipose tissue function...
  66. ncbi Comparison of open dilatational tracheostomy with conventional pediatric tracheostomy in a growing animal model
    Chung Hwan Baek
    Department of Otorhinolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Laryngoscope 115:2193-8. 2005
    To compare the tracheal changes after applying a new open dilatational tracheostomy (ODT) technique with those from a conventional open tracheostomy (COT) with vertical cartilage incision in a growing animal model.
  67. doi Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio)
    Jith K Thomas
    Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Aquat Toxicol 130:112-22. 2013
    ..standard metabolic rate [SMR], active metabolic rate [AMR], factorial aerobic scope [F-AS] and cost of transport [COT]) and gene expression of energy metabolism and methionine catabolism enzymes in adult zebrafish...
  68. pmc Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice
    Irene Kyrmizi
    2 Div of Allergy, Clinical Immunology and Rheumatology, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595, USA
    J Leukoc Biol 94:751-7. 2013
    The MAPK3 Tpl2 controls innate and adaptive immunity by regulating TLR, TNF-α, and GPCR signaling in a variety of cell types...
  69. ncbi Of earprints, fingerprints, scent dogs, cot deaths and cognitive contamination--a brief look at the present state of play in the forensic arena
    A P A Broeders
    Department of Criminal Law and Criminology, Leiden University, Netherlands Forensic Institute, The Hague, Netherlands
    Forensic Sci Int 159:148-57. 2006
    ..Finally, a number of measures are proposed which may go some way to address some of the present concerns over the evaluation of technical and scientific evidence...
  70. doi Initial validation of the prekindergarten Classroom Observation Tool and goal setting system for data-based coaching
    April D Crawford
    Department of Pediatrics, Children s Learning Institute, University of Texas Health Science Center at Houston
    Sch Psychol Q 28:277-300. 2013
    ..This study explains the development of the prekindergarten (pre-k) Classroom Observation Tool (COT) designed for use in a data-based coaching model...
  71. ncbi Sudden infant death syndrome (SIDS) or cot death: a review
    Chigozie N Ogbu
    Department of Paediatrics and Child Health, Ebonyi State University Teaching Hospital, Abakaliki, Ebonyi State
    West Afr J Med 22:88-91. 2003
    ..Sudden infant death syndrome (SIDS) or cot death is a diagnostic entity which can be applied in such a case...
  72. ncbi Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs
    Ying Zhang
    State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Taian, China
    Pharmazie 68:850-4. 2013
    Celastrus orbiculatus Thunb. (COT) is a traditional Chinese herb...
  73. pmc Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination
    Wen Jane Lee
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan Department of Social Work, Tunghai University, Taichung, Taiwan
    Neoplasia 15:1036-48. 2013
    ..The role of protein tumor progression locus 2 (Tpl2) in angiogenic factor-related endothelial cell angiogenesis is still unclear...
  74. ncbi Sink fast and swim harder! Round-trip cost-of-transport for buoyant divers
    Patrick J O Miller
    Sea Mammal Research Unit, School of Biology, University of St Andrews, Fife KY16 9QQ, UK
    J Exp Biol 215:3622-30. 2012
    ..body condition, determines the apparent weight (buoyancy) of divers, which may affect round-trip cost-of-transport (COT) between the surface and depth...
  75. pmc IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400
    Karine Roget
    Division of Immune Cell Biology, MRC National Institute for Medical Research, London, United Kingdom
    Mol Cell Biol 32:4684-90. 2012
    b>Tumor progression locus 2 (TPL-2) functions as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular signal-regulated kinase 1 and 2 (ERK-1/2) mitogen-activated protein (MAP) kinases in ..
  76. pmc Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105
    Huei Ting Yang
    Division of Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
    Mol Cell Biol 32:3438-51. 2012
    ..Unexpectedly, TPL-2 promoted soluble TNF production independently of IKK-induced p105 phosphorylation and its ability to activate ERK, which has important implications for the development of anti-inflammatory drugs targeting TPL-2...
  77. pmc Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse
    Alicia Grattan
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Ann Fam Med 10:304-11. 2012
    Opioid misuse in the context of chronic opioid therapy (COT) is a growing concern. Depression may be a risk factor for opioid misuse, but it has been difficult to tease out the contribution of co-occurring substance abuse...
  78. doi Cloning and characterization of chromosomal markers from a Cot-1 library of peanut (Arachis hypogaea L.)
    L Zhang
    School of Life Sciences, Institute of Plant Molecular Biology and Agricultural Biotechnology, State China Key Laboratory for Agrobiotechnology, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong, SAR, China
    Cytogenet Genome Res 137:31-41. 2012
    ..In our study, a peanut Cot-1 library was constructed to isolate highly and moderately repetitive sequences from the cultivated peanut, and the ..
  79. doi High-throughput sex identification by melting curve analysis in blue-breasted quail and chicken
    C C Chen
    Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Theriogenology 77:1951-8. 2012
    ..chinensis. Based on sequence alignment, a female-specific CHD-W primer (W-cot-F1) and a female/male (or CHD-W/CHD-Z)-common primer (ZW-cot-F1) were redesigned for use in combination with the ..
  80. doi Simultaneous analysis of biologically active pyridines in pharmaceutical formulations by capillary zone electrophoresis
    Nantana Nuchtavorn
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    J Chromatogr Sci 50:151-6. 2012
    ..e., nicotine (NIC), cotinine (COT), nicotinic acid (NA), and nicotinamide (NM)]...
  81. doi Intervention of drudgery reducing technologies in agriculture and impact evaluation
    Manju Mehta
    Deptt of Family Resource Management, College of Home Science, CCS Haryana Agricultural University, Hisar, 125004 India
    Work 41:5003-8. 2012
    ..An intervention package consisting of improved sickle, wheel hand hoe, capron, cot bag and protective gloves was introduced in village Shahpur...
  82. doi Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGF
    Prem Khanal
    College of Pharmacy, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
    Carcinogenesis 30:682-9. 2009
    ..These results indicated that the Ser413 of Tpl-2 plays an important role in EGF-induced carcinogenesis as well as inactivation of the p53...
  83. doi Low metabolic cost of locomotion in ornate box turtles, Terrapene ornata
    Peter A Zani
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Exp Biol 211:3671-6. 2008
    Evolution has produced a wide range of body plans, but for a given body mass, the energetic cost of transport (COT) of terrestrial animals falls in a relatively narrow range...
  84. ncbi Bonding nature and electron delocalization of An(COT)2, An = Th, Pa, U
    Dayán Páez-Hernández
    Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andrés Bello, República 275, Santiago, Chile
    J Phys Chem A 115:8997-9003. 2011
    A systematic study of a series of An(COT)(2) compounds, where An = Th, Pa, U, and COT represents cyclooctatetraene, has been performed using relativistic density functional theory...
  85. doi Combat ocular trauma visual outcomes during operations iraqi and enduring freedom
    Eric D Weichel
    Walter Reed Army Medical Center, Washington, District of Columbia 20307, USA
    Ophthalmology 115:2235-45. 2008
    To report the visual and anatomic outcomes as well as to predict the visual prognosis of combat ocular trauma (COT) during Operations Iraqi and Enduring Freedom.
  86. ncbi Clinical, socioeconomic and patient outcomes of intensive versus conventional scaling and root planing in the treatment of periodontal infection
    Sara Hed Rann
    Department of Periodontology, The Gävle County Hospital, Gavle, Sweden
    Oral Health Prev Dent 6:303-8. 2008
    ..To compare the two non-surgical periodontal treatment methods with regard to socioeconomic aspects, treatment results and complications...
  87. doi Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production
    Kevin Cusack
    Abbott Laboratories, Medicinal Chemistry, 100 Research Drive, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 19:1722-5. 2009
    COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway...
  88. doi Operational tolerance after liver transplantation
    Giuseppe Orlando
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, Headington, Oxford OX3 9DU, UK
    J Hepatol 50:1247-57. 2009
    ..While clinical operational tolerance (COT) remains the exception after other types of solid organ transplantation, several cases of COT have been described ..
  89. doi Comparative cytogenetics of giant trahiras Hoplias aimara and H. intermedius (Characiformes, Erythrinidae): chromosomal characteristics of minor and major ribosomal DNA and cross-species repetitive centromeric sequences mapping differ among morphologicall
    D R Blanco
    Departamento de Genetica e Evolucao, Universidade Federal de Sao Carlos, Sao Carlos, SP Brazil
    Cytogenet Genome Res 132:71-8. 2011
    ..double-staining) and fluorescent in situ hybridization (FISH) with 5S, 18S rDNA probes and cross-species Cot-1 DNA probing...
  90. doi Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewes
    M J Zhu
    Center for the Study of Fetal Programming, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
    Placenta 30:405-10. 2009
    ..the activity of AMPK and its role in the observed down-regulation of insulin/IGF-1 signaling in cotyledonary (COT) arteries supplying the placental component of the ewe placentome...
  91. pmc Surface-initiated ring-opening metathesis polymerization in the vapor phase: an efficient method for grafting cyclic olefins with low strain energies
    Maria Felisa Z Lerum
    Chemistry Department, Mount Holyoke College, South Hadley, Massachusetts 01075, United States
    Langmuir 27:5403-9. 2011
    ..CHD), cycloheptene (CHP), cis-cyclooctene (CO), cis,cis-1,5-cyclooctadiene (COD), 1,3,5,7-cyclooctatetraene (COT), cyclododecene (CD), and trans,trans,cis-1,5,9-cyclododecatriene (CDT), was explored using ring-opening metathesis ..
  92. doi FISH applications for genomics and plant breeding strategies in tomato and other solanaceous crops
    D Szinay
    Laboratory of Genetics, Wageningen University and Research Centre, Wageningen, The Netherlands
    Cytogenet Genome Res 129:199-210. 2010
    ..Repeat-rich areas of the chromosomes can also be demonstrated by hybridisation of probed Cot fractions of sheared genomic DNA; a powerful method to elucidate the heterochromatin domains for genomic studies...
  93. doi Laboratory and field testing of bednet traps for mosquito (Diptera: Culicidae) sampling in West Java, Indonesia
    Craig A Stoops
    Navy Medical Research Unit 2, U S Embassy Jakarta, Unit 8132 NAMRU 2, FPO AP 96520 8132, Indonesia
    J Vector Ecol 35:187-96. 2010
    ..In the laboratory we tested human-baited and unbaited CDC light trap/cot bednet (CDCBN) combinations against three types of traps: the Mbita Trap (MIBITA), a Tent Trap (TENT), and a ..
  94. pmc Chronic opioid therapy and preventive services in rural primary care: an Oregon rural practice-based research network study
    David I Buckley
    Oregon Rural Practice Based Research Network, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Ann Fam Med 8:237-44. 2010
    ..Consequent stresses on clinical encounters might adversely affect some elements of clinical care. We evaluated a possible association between chronic opioid therapy (COT) for CNCP and receipt of various preventive services.
  95. pmc Testing the equal environments assumption in the Children of Twins design
    Laura B Koenig
    Family Research Center, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, USA
    Behav Genet 40:533-41. 2010
    In a Children of Twins (COT) design, the environmental and genetic risk of a child is, in part, dependent upon the status of the father and the father's cotwin...
  96. doi Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation
    Kenjiro Bandow
    Department of Oral Biochemistry, Field of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Biochem Biophys Res Commun 402:755-61. 2010
    ..signal-regulated kinases (ERKs), whose activation by LPS requires the upstream serine/threonine kinase, Cot/Tpl2. To determine the signal molecules responsible for the inhibitory effects of LPS on osteoblast differentiation, we ..
  97. pmc Time-scheduled vs. pain-contingent opioid dosing in chronic opioid therapy
    Michael Von Korff
    Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
    Pain 152:1256-62. 2011
    ..recommend time-scheduled opioid dosing over pain-contingent dosing for patients receiving chronic opioid therapy (COT)...
  98. doi Involvement of Cot/Tp12 in bone loss during periodontitis
    T Ohnishi
    Department of Developmental Medicine, Kagoshima University, Sakuragaoka, Japan
    J Dent Res 89:192-7. 2010
    ..The binding of lipopolysaccharide to Toll-like receptors causes phosphorylation of Cot/Tp12 to activate the MAPK cascade...
  99. doi Cyclic tetrathiophenes planarized by silicon and sulfur bridges bearing antiaromatic cyclooctatetraene core: syntheses, structures, and properties
    Takeshi Ohmae
    Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Am Chem Soc 132:1066-74. 2010
    ..1, 2, and 3 planarized by dimethylsilyl, sulfur, and sulfone bridges bearing an antiaromatic cycloocatatetraene (COT) core were designed and synthesized to investigate the relationship among the bent angle, paratropicity, and HOMO-..
  100. pmc Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:105-13. 2010
    The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha...

Research Grants65

  1. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
    ..Studies outlined in this grant application will test hypotheses concerning how the actions of Tumor Progression Locus 2 (TPL2), an 'upstream'mediator of inflammatory signaling, promote obesity-associated ..
  2. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew Greenberg; Fiscal Year: 2009
    ..Studies outlined in this grant application will test hypotheses concerning how the actions of Tumor Progression Locus 2 (TPL2), an 'upstream' mediator of inflammatory signaling, promote obesity-associated ..
  3. Tpl2 in Intestinal Tumorigenesis
    Philip N Tsichlis; Fiscal Year: 2010
    The proto-oncogene encoding the Tpl2 kinase is activated by provirus integration in retrovirus-induced rodent lymphomas and mammary adenocarcinomas...
  4. International Conference on Tobacco Induced Diseases
    Denis Kinane; Fiscal Year: 2004
    ..Periodontitis;12. Heart disease;13. Pregnancy complications; 14. Sudden Infant Death Syndrome (Cot Death); 15. Birth Defects Treatment: 15. Molecular biology of cancer/xenobiotics gene polymorphisms; 16...
  5. Regulation of the Tp12 Kinase
    Philip Tsichlis; Fiscal Year: 2009
    ..Overexpression of Tpl2 in a variety of cell types activates ERK, JNK, p38 MAPK, and the transcription factors NF-AT and NF-KB...
  6. ROLE OF TPL-2, CYCLIN D1 AND TOUVLO IN BREAST CANCER
    Christos Patriotis; Fiscal Year: 2002
    ..The obtained result will enhance our understanding of the growth regulation of normal and neoplastic mammary epithelia and may identify molecular markers for diagnosis and therapeutic intervention. ..
  7. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ..These sheep red blood cell (SRBC) proteins are functionally associated with the Na/K pump and K-CI cotransporter (COT)...
  8. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2007
    ..translocation of PP2A to the tight junction by c-Src dependent mechanism, 5) expression of dominant negative PP2A-Cot and reduced expression by antisense oligos prevent oxidative stress-induced disruption of the tight junction, 6) ..
  9. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2010
    ..Over the past few years, we have made seminal findings demonstrating a pivotal TLR signaling axis: the IKK/Tpl2 axis...
  10. ROLE OF TVI 1 IN APOPTOSIS
    Philip Tsichlis; Fiscal Year: 2004
    ..This application addresses the role of Tvl-1 in the assembly and function of such complexes. ..
  11. Offspring of Twins: G,E and GxE Risks for Alcoholism
    Theodore Jacob; Fiscal Year: 2009
    ..Our approach is distinguished by two significant design characteristics: (1) use of the powerful children of twins (COT) design involving twins in the parent generation who are concordant or discordant for alcohol dependence (and ..
  12. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2003
    ..Interestingly, one of the putative IKK upstream kinases, Cot, physically interacts with Tax...
  13. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2011
    ..Over the past few years, we have made seminal findings demonstrating a pivotal TLR signaling axis: the IKK/Tpl2 axis...