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Genomes and Genes
| MAP3K8SummaryGene Symbol: MAP3K8 Description: mitogen-activated protein kinase kinase kinase 8 Alias: COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, Ewing sarcoma transformant, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2 Species: human Top Publications
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Publications
Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activityHong Seok Choi
Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
FASEB J 22:113-26. 2008..The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family...- Structure and transforming potential of the human cot oncogene encoding a putative protein kinaseJ Miyoshi
Department of Oncogene Research, Osaka University, Japan
Mol Cell Biol 11:4088-96. 1991..from hamster SHOK cells transformed with DNA extracted from a human thyroid carcinoma cell line and named the cot (cancer Osaka thyroid) oncogene... - Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcriptionLawrence P Kane
Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
Mol Cell Biol 22:5962-74. 2002The Akt (or protein kinase B) and Cot (or Tpl-2) serine/threonine kinases are associated with cellular transformation. These kinases have also been implicated in the induction of NF-kappa B-dependent transcription... - Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformationM Chiariello
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
Mol Cell Biol 20:1747-58. 2000The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family implicated in cellular transformation... 
Cot kinase regulation of IL-2 production in Jurkat T cellsA Ballester
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina Universidad Autonoma de Madrid, Spain
J Immunol 159:1613-8. 1997..b>cot is a very closely related gene, if not the human homologue...- Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant mannerA Ballester
Instituto de Investigaciones Biomedicas, CSIC, Facultad Medicina Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
J Biol Chem 273:14099-106. 1998b>Cot kinase is a protein serine/threonine kinase, classified as a mitogen-activated protein kinase kinase kinase, implicated in T lymphocyte activation... - Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinaseA Salmeron
Division of Cellular Immunology, National Institute of Medical Research, London, UK
EMBO J 15:817-26. 1996..Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1... - The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translationM Aoki
Department of Oncogene Research, Osaka University, Japan
J Biol Chem 268:22723-32. 1993The cot gene is an oncogene encoding serine/threonine kinases isolated by DNA transfection assay... - The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2Aristides G Eliopoulos
The Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
J Virol 76:4567-79. 2002..In this study, we have identified the oncogenic kinase Tpl-2/Cot as a novel component of LMP1-induced NF-kappaB signaling... - TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105M P Belich
Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, UK
Nature 397:363-8. 1999..a carboxy-terminal-deleted form, as an oncoprotein in rats and is more than 90% identical to the human oncoprotein COT. Expression of TPL-2 results in phosphorylation and increased degradation of p105 while maintaining p50 production... 
Evaluation of the phototoxic potential of plants used in oriental medicineKi Min Bark
Department of Chemical Education and Research Institute of Life Science, Gyeongsang National University, Jinju, 660 701, South Korea
J Ethnopharmacol 127:11-8. 2010..Phototoxicity can be either harmful or beneficial. Yet the phototoxicity of oriental medicinal plants is an understudied area. The purpose of this study is to fill in this gap...- Effect of a sudden infant death syndrome risk reduction education program on risk factor compliance and information sources in primarily black urban communitiesKenneth A Rasinski
National Opinion Research Center at the University of Chicago, Chicago, Illinois 60637, USA
Pediatrics 111:e347-54. 2003..The continued racial disparity in SIDS is thought to be attributable to lack of compliance with SIDS risk reduction recommendations... - Transposon tagging and the study of root development in ArabidopsisR Tsugeki
Biotechnology Institute, The Pennsylvania State University, University Park, USA
Gravit Space Biol Bull 11:79-87. 1998..A gene expressed in root cap cells tagged with an enhancer-trap Ds was isolated and its corresponding EST cDNA was identified... - Marine bacteria comprise a possible indicator of drowning in seawaterEiji Kakizaki
Section of Legal Medicine, Department of Social Medicine, Faculty of Medicine Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
Forensic Sci Int 176:236-47. 2008..Blue colonies stained using the cytochrome oxidase test (COT), were detected in blood mixed with both sea and river water... - Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosisT B Larsen
Department of Clinical Biochemistry, Vejle County Central Hospital, Vejle, Denmark
Thromb Res 98:233-9. 2000Sudden infant death syndrome or "cot death" has until the late eighties been a significant cause of death in children between the ages of 1 month and 1 year... - Skin-to-skin care with the father after cesarean birth and its effect on newborn crying and prefeeding behaviorKerstin Erlandsson
Department of Woman and Child Health, Division of Reproductive and Perinatal Health, Karolinska Institutet, Stockholm, Sweden
Birth 34:105-14. 2007..of skin-to-skin contact on crying and prefeeding behavior in healthy, full-term infants born by elective cesarean birth and cared for skin-to-skin with their fathers versus conventional care in a cot during the first 2 hours after birth. - Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activityJ Lingner
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
Proc Natl Acad Sci U S A 94:11190-5. 1997..Previous characterization of yeast telomerase function in vivo identified four EST (for ever shorter telomeres) genes that, when mutated, result in the phenotypes expected for a defect in telomerase... - Regulation of K-Cl cotransport: from function to genesN C Adragna
Department of Pharmacology, Wright State University, School of Medicine, Dayton, OH 45435 0002, USA
J Membr Biol 201:109-37. 2004This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation from a functional and genetic viewpoint... - Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophagesKatie J Loniewski
Division of Pathology, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
Mol Immunol 44:3715-23. 2007..7, a mouse macrophage cell line. ERK activation in macrophages by TLR4 and -7 is mediated via a MAP3K, called TPL2/COT, which under unstimulated conditions is associated with NF kappa B1 p105, a member of the I kappa B family of .. - Circadian rhythms and enhanced athletic performance in the National Football LeagueR S Smith
Stanford University Sleep Disorders Clinic, CA 94305, USA
Sleep 20:362-5. 1997..m. Eastern Standard Time (EST) from the 1970-1994 seasons... - Characterization of cotJ, a sigma E-controlled operon affecting the polypeptide composition of the coat of Bacillus subtilis sporesA O Henriques
Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Bacteriol 177:3394-406. 1995..Studies with double-reporter strains bearing a cotJ-gusA fusion and lacZ fusions to other cot genes confirmed that expression of cotJ is initiated during sporulation prior to activation of genes known to .. - Treatment patterns in elderly patients (greater than or equal to 70 years) with breast carcinoma. A retrospective study of the Gruppo Oncologico Clinico Cooperativo del nord-Est (GOCCNE)D Crivellari
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 77:136-40. 1991..Comorbid conditions are of particular concern in therapy planning, considering that more stage III patients died of competing causes than for disease progression. The role of chemotherapy was very marginal... - Practice variation in the transfer of premature infants from incubators to open cots in Australian and New Zealand neonatal nurseries: results of an electronic surveyKaren New
The University of Queensland, School of Nursing and Midwifery, Royal Brisbane and Women s Hospital, Butterfield Street, Brisbane, Queensland 4029, Australia
Int J Nurs Stud 47:678-87. 2010..of the premature infant but the infant is ultimately required to make a successful transfer from incubator to open cot in order to be discharged from hospital... - Strategies to improve photostabilities in ultrasensitive fluorescence spectroscopyJerker Widengren
Experimental Biomolecular Physics, Department of Applied Physics, AlbaNova University Center, Royal Institute of Technology, SE 10691 Stockholm, Sweden
J Phys Chem A 111:429-40. 2007..gallate, nPG, ascorbic acid, AA) and triplet state quenchers (mercaptoethylamine, MEA, cyclo-octatetraene, COT), were investigated, and the relevant rate parameters involved were determined for the dye Rhodamine 6G... - The beginnings of modern psychiatric treatment in Europe. Lessons from an early account of convulsive therapyBrigitta Baran
Dept of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Eur Arch Psychiatry Clin Neurosci 258:434-40. 2008Convulsive therapy (COT) is a major European contribution to the psychiatric armamentarium and biological psychiatry. COT was introduced in psychiatry by László Meduna, a Hungarian neuropsychiatrist... - Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusingG Barnert
,
Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI... - Who's got what? A benchmarking exercise for tertiary neonatal unitsC A Kuschel
Newborn Services, National Women s Health, Auckland District Health Board, Auckland, New Zealand
J Paediatr Child Health 41:635-9. 2005..Background: Many current NNU in Australia and New Zealand are planning new or redesigning existing facilities. There are no adequate local standards for NNU design available which reflect changing neonatal practices... - Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertionA Makris
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
J Virol 67:4283-9. 1993..Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity... - The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptorsK H Ruan
Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
Biochem J 274:849-54. 1991..electric ray) and human acetylcholine receptors (AChR) were localized by reaction of 125I-labelled cobrotoxin (Cot) and erabutoxin b (Eb) with synthetic overlapping peptides spanning the entire extracellular part of the respective .. - Antibiotic resistance of Salmonella enterica serovar Paratyphi A in India: emerging and reemerging problemShyamapada Mandal
Department of Bacteriology and Serology, Calcutta School of Tropical Medicine, C R Avenue, Kolkata 700073, India
J Postgrad Med 52:163-6. 2006..Antibiotic resistance pattern and R-plasmid of Salmonella enterica serovar Paratyphi A isolates from Kolkata, India are not well documented... - Reducing medication errors in the neonatal intensive care unitJ H Simpson
Paediatric Department, Princess Royal Maternity Hospital, Glasgow G31 2ER, Scotland, UK
Arch Dis Child Fetal Neonatal Ed 89:F480-2. 2004..Medication errors are common in the neonatal intensive care unit (NICU). Various strategies to reduce errors have been described in adult and paediatric patients but there are few published data on their effect in the NICU... - Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazoneEmirhan Nemutlu
Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Sihhiye, Ankara, Turkey
Talanta 80:117-26. 2009..of seven cephalosporins [Cefepime (CEP), ceftazidime (CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and cefoperazone (COP)] in human plasma and amniotic fluid has been developed... - High-performance liquid chromatographic assay for N-glucuronidation of nicotine and cotinine in human liver microsomesMiki Nakajima
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa, 920 0934, Japan
Anal Biochem 302:131-5. 2002..The nicotine N-glucuronide (Nic-glu) and cotinine N-glucuronide (Cot-glu) formed were analyzed by ion-pair chromatography with a C-18 column... - Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cordT Kato
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
Glia 30:209-18. 2000..Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1-positive cells and OEC nuclei within the repaired lesion... - Occurrence of Escherichia coli O157 in raw material and food in Czech RepublicJ Lukásová
Department of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, The Czech Republic
J Vet Med B Infect Dis Vet Public Health 51:77-81. 2004..GEN), colistin (COL), cephalozine (CLZ), cefoxitin (CXT), aztreonam (AZT), and sulphamethoxazole + trimethoprim (COT) was tested using the standard dilution technique and disc diffusion test... - The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassaSabine Maerz
Institut für Mikrobiologie und Genetik Abteilung Molekulare Mikrobiologie, Universitat Gottingen, D 37077 Gottingen, Germany
Genetics 179:1313-25. 2008..Here, we identify the cot-1 suppressor gul-4 as mak-2 and show that mutants of the gul-4/mak-2 mitogen-activated protein (MAP) kinase pathway .. - Perforating globe injuries during operation Iraqi FreedomMarcus H Colyer
Ophthalmology Service, Walter Reed Army Medical Center, Washington, DC, USA
Ophthalmology 115:2087-93. 2008..with perforating (through-and-through) injuries of the globe and the visual impact of these injuries on patients with combat ocular trauma (COT) seen at Walter Reed Army Medical Center (WRAMC) from March 2003 through October 2006. - Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammationIrene Soria-Castro
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid 28029
J Biol Chem 285:33805-15. 2010Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo... - BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytesValeriu B Cismasiu
Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, U S A
Biochem J 417:457-66. 2009..of IkappaB kinase in the TCR/CD28 signalling pathway was affected by increased BCL11B expression, and found that Cot (cancer Osaka thyroid oncogene) kinase mRNA levels were elevated... - Characterization of X-chromosome inactivation status in human pluripotent stem cellsJennifer A Erwin
Howard Hughes Medical Institute, Boston, Massachusetts, USA
Curr Protoc Stem Cell Biol . 2010This unit describes a method of performing fluorescent in situ hybridization (FISH) of XIST and Cot-1 RNA in human pluripotent stem cells (hPSC) to characterize the epigenetic status of X-chromosome inactivation (XCI)... - Head covering and the risk for SIDS: findings from the New Zealand and German SIDS case-control studiesEdwin A Mitchell
University of Auckland, Department of Paediatrics, Private Bag 92019, Auckland, New Zealand
Pediatrics 121:e1478-83. 2008..By using the data from 2 sudden infant death syndrome case-control studies, consistency of the findings could be assessed... - Molecular differentiation of sex chromosomes probed by comparative genomic hybridizationW Traut
Institut fur Biologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Chromosoma 108:173-80. 1999..simultaneously with FluorX-labelled DNA of females and Cy3-labelled DNA of males in the presence of an excess of Cot-1 DNA or unlabelled DNA of the homogametic sex... - Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activityM Morillas
Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
J Biol Chem 276:45001-8. 2001Carnitine palmitoyltransferase I (CPT I) and carnitine octanoyltransferase (COT) catalyze the conversion of long- and medium-chain acyl-CoA to acylcarnitines in the presence of carnitine... - Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placentaJ M Evoniuk
Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA
Placenta 29:422-8. 2008..were collected at day 130, and placentomes were either separated into caruncular (CAR; maternal) or cotyledonary (COT; fetal) placenta and snap-frozen for PrPC mRNA expression or perfusion fixed for PrPC protein expression... - Maintenance treatment of gastroesophageal reflux disease: an evaluation of continuous and on-demand therapy with rabeprazole 20 mgD G Morgan
Division of Gastroenterology, St Joseph s Healthcare, Hamilton, Canada
Can J Gastroenterol 21:820-6. 2007To evaluate continuous therapy (COT) and on-demand therapy (ODT) with rabeprazole 20 mg for maintenance in uninvestigated gastroesophageal reflux disease (GERD). - Genes encoding spore coat polypeptides from Bacillus subtilisW Donovan
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
J Mol Biol 196:1-10. 1987..To determine the location of the cot genes on the chromosome and to study their function genetically, we tagged each gene by insertion of a .. - Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase familyJ A Zallen
Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Department of Anatomy and Department of Biochemistry and Biophysics, The University of California, San Francisco, California 94143, USA
Mol Biol Cell 11:3177-90. 2000..kinase in the Ndr family that is related to the Orb6 (Schizosaccharomyces pombe), Warts/Lats (Drosophila), and COT-1 (Neurospora) kinases that function in cell shape regulation... - Syntheses and crystal structures of ruthenium and rhodium olefin complexes containing GaCpThomas Cadenbach
Anorganische Chemie II Organometallics and Materials, Ruhr Universitat Bochum, D 44780 Bochum, Germany
Inorg Chem 48:5021-6. 2009..of the olefin ligands to give [Ru(PPh(3))(2)(GaCp*)(3)] (2), whereas reaction of [Ru(eta(2),eta(2)-COD)(eta(6)-COT)] (COD = 1,5-cyclooctadiene, C(8)H(12), COT = 1,3,5-cyclooctatriene, C(8)H(10)) and GaCp* leads to [Ru(eta(2),eta(2).. - Integration of Cot analysis, DNA cloning, and high-throughput sequencing facilitates genome characterization and gene discoveryDaniel G Peterson
Center for Applied Genetic Technologies and Department of Crop and Soil Sciences, University of Georgia, Athens, Georgia 30602, USA
Genome Res 12:795-807. 2002b>Cot-based sequence discovery represents a powerful means by which both low-copy and repetitive sequences can be selectively and efficiently fractionated, cloned, and characterized... - Clothing fabric does not affect thermoregulation during exercise in moderate heatT P Gavin
Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
Med Sci Sports Exerc 33:2124-30. 2001..We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics... - Carnitine acyltransferases are not changed in Alzheimer diseaseI Maurer
Department of Neurology, , Bonn, Germany
Alzheimer Dis Assoc Disord 12:71-6. 1998We evaluated the activities of carnitine palmitoyltransferase (CPT), carnitine octanoyltransferase (COT), and carnitine acetyltransferase (CAT) in the frontal cortex, temporal cortex, parietal cortex, hippocampus, and cerebellum of .. - Impact of a conjugate vaccine on community-wide carriage of nonsusceptible Streptococcus pneumoniae in AlaskaMatthew R Moore
Division of Applied Public Health Training, Epidemiology Program Office, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Infect Dis 190:2031-8. 2004..Antimicrobial resistance among pneumococci has increased in recent years and complicates treatment. The introduction of heptavalent pneumococcal conjugate vaccine (PCV7) could reduce acquisition of antimicrobial-resistant pneumococci... - Integrated in silico and biological validation of the blocking effect of Cot-1 DNA on Microarray-CGHSeung Hui Kang
Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
Int J Mol Med 19:901-8. 2007In array-CGH, various factors may act as variables influencing the result of experiments. Among them, Cot-1 DNA, which has been used as a repetitive sequence-blocking agent, may become an artifact-inducing factor in BAC array-CGH... - Cryogenic oven-trapping gas chromatography for analysis of volatile organic compounds in body fluidsK Watanabe-Suzuki
Department of Legal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
Anal Bioanal Chem 373:75-80. 2002Cryogenic oven-trapping (COT) with capillary GC has been successfully applied to analysis of chloroform, dichloromethane, trichloroethylene, diethyl ether, the components of solvent thinner (ethyl acetate, benzene, n-butanol, toluene, .. - Does acupuncture improve the orthopedic management of chronic low back pain--a randomized, blinded, controlled trial with 3 months follow upAlbrecht F Molsberger
Orthopedic Surgery and Research, Kasernenstr 1b, 40213, Dusseldorf, Germany
Pain 99:579-87. 2002..5 years, 0.5-2 years, 2-5 years, >or=5 years. Analysis was by intention to treat. Group 1 (Verum+COT) received 12 treatments of verum acupuncture and conservative orthopedic treatment (COT)... - A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotineA J Ji
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Clin Chem 45:85-91. 1999..In an attempt to assess THOC and cotinine (COT) concentrations during nicotine transdermal therapy, we developed a new quantitative gas chromatography-mass .. - Comparison of open dilatational tracheostomy with conventional pediatric tracheostomy in a growing animal modelChung Hwan Baek
Department of Otorhinolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
Laryngoscope 115:2193-8. 2005To compare the tracheal changes after applying a new open dilatational tracheostomy (ODT) technique with those from a conventional open tracheostomy (COT) with vertical cartilage incision in a growing animal model. - Traumatic brain injury associated with combat ocular traumaEric D Weichel
Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Ave, Washington, DC 20307, USA
J Head Trauma Rehabil 24:41-50. 2009To determine the impact of traumatic brain injury (TBI) on visual outcomes in combat ocular trauma (COT) and determine the association between TBI severity and types of ocular injuries. - Randomised trial of infant sleep location on the postnatal wardH L Ball
Parent Infant Sleep Laboratory and Medical Anthropology Research Group, Department of Anthropology, Durham University, Durham, UK
Arch Dis Child 91:1005-10. 2006..To determine whether postnatal mother-infant sleep proximity affects breastfeeding initiation and infant safety... - Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysisJennifer Jager
Institut National de la Sante et de la Recherche Medicale INSERM, U895, Mediterranean Center of Molecular Medicine, Team 7 Molecular and Cellular Physiopathology of Obesity and Diabetes, Nice, France
Diabetes 59:61-70. 2010..This study aims at identifying proteins regulating ERK1/2 activity, specifically in response to inflammatory cytokines, to provide new insights into mechanisms leading to abnormal adipose tissue function... - Growth and survival of bacteria implicated in sudden infant death syndrome on cot mattress materialsR O Jenkins
School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK
J Appl Microbiol 99:573-9. 2005To compare growth and survival of selected bacteria implicated in sudden infant death syndrome (SIDS) on cot mattress polyurethane (PU) inner-foams and on different types of cot mattress cover materials. - The efficacy of noncontact oxygen delivery methodsPatrick Davies
Luton and Dunstable NHS Trust, Luton, United Kingdom
Pediatrics 110:964-7. 2002..We wished to assess the concentration of oxygen delivered to the patient with various methods of "wafting" oxygen... - Inflammatory signaling pathways regulating ApoE gene expression in macrophagesAnca V Gafencu
Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
J Biol Chem 282:21776-85. 2007.... - Sink fast and swim harder! Round-trip cost-of-transport for buoyant diversPatrick J O Miller
Sea Mammal Research Unit, School of Biology, University of St Andrews, Fife KY16 9QQ, UK
J Exp Biol 215:3622-30. 2012..body condition, determines the apparent weight (buoyancy) of divers, which may affect round-trip cost-of-transport (COT) between the surface and depth... - IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400Karine Roget
Division of Immune Cell Biology, MRC National Institute for Medical Research, London, United Kingdom
Mol Cell Biol 32:4684-90. 2012b>Tumor progression locus 2 (TPL-2) functions as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular signal-regulated kinase 1 and 2 (ERK-1/2) mitogen-activated protein (MAP) kinases in .. - Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105Huei Ting Yang
Division of Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
Mol Cell Biol 32:3438-51. 2012..Unexpectedly, TPL-2 promoted soluble TNF production independently of IKK-induced p105 phosphorylation and its ability to activate ERK, which has important implications for the development of anti-inflammatory drugs targeting TPL-2... - High-throughput sex identification by melting curve analysis in blue-breasted quail and chickenC C Chen
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
Theriogenology 77:1951-8. 2012..chinensis. Based on sequence alignment, a female-specific CHD-W primer (W-cot-F1) and a female/male (or CHD-W/CHD-Z)-common primer (ZW-cot-F1) were redesigned for use in combination with the .. - Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuseAlicia Grattan
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
Ann Fam Med 10:304-11. 2012Opioid misuse in the context of chronic opioid therapy (COT) is a growing concern. Depression may be a risk factor for opioid misuse, but it has been difficult to tease out the contribution of co-occurring substance abuse... - Cloning and characterization of chromosomal markers from a Cot-1 library of peanut (Arachis hypogaea L.)L Zhang
School of Life Sciences, Institute of Plant Molecular Biology and Agricultural Biotechnology, State China Key Laboratory for Agrobiotechnology, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong, SAR, China
Cytogenet Genome Res 137:31-41. 2012..In our study, a peanut Cot-1 library was constructed to isolate highly and moderately repetitive sequences from the cultivated peanut, and the .. - Simultaneous analysis of biologically active pyridines in pharmaceutical formulations by capillary zone electrophoresisNantana Nuchtavorn
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
J Chromatogr Sci 50:151-6. 2012..e., nicotine (NIC), cotinine (COT), nicotinic acid (NA), and nicotinamide (NM)]... - Intervention of drudgery reducing technologies in agriculture and impact evaluationManju Mehta
Deptt of Family Resource Management, College of Home Science, CCS Haryana Agricultural University, Hisar, 125004 India
Work 41:5003-8. 2012..An intervention package consisting of improved sickle, wheel hand hoe, capron, cot bag and protective gloves was introduced in village Shahpur... - Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans: The TROUP StudyMark D Sullivan
Department of Psychiatry and Behavioral Sciences, Division of Consultation Liaison Psychiatry, University of Washington, Seattle, WA 98195 6560, USA
Pain 150:332-9. 2010The use of chronic opioid therapy (COT) for chronic non-cancer pain (CNCP) has increased dramatically in the past two decades. There has also been a marked increase in the abuse of prescribed opioids and in accidental opioid overdose... - Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha productionKevin Cusack
Abbott Laboratories, Medicinal Chemistry, 100 Research Drive, Worcester, MA 01605, USA
Bioorg Med Chem Lett 19:1722-5. 2009COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway... - Clinical, socioeconomic and patient outcomes of intensive versus conventional scaling and root planing in the treatment of periodontal infectionSara Hed Rann
Department of Periodontology, The Gävle County Hospital, Gavle, Sweden
Oral Health Prev Dent 6:303-8. 2008..To compare the two non-surgical periodontal treatment methods with regard to socioeconomic aspects, treatment results and complications... - Tpl-2/Cot and COX-2 in breast cancerZuzana Krcova
Laboratory of Molecular Pathology, Department of Pathology, Faculty of Medicine and Dentistry, Palacky University, University Hospital, Olomouc, Czech Republic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152:21-5. 2008..In addition to histological type, grade, stage, hormonal and c-erbB2 status there is therefore a strong need for new and reliable prognostic and predictive factors... - Cost of transport and optimal swimming speed in farmed and wild European silver eels (Anguilla anguilla)Arjan Palstra
Institute of Biology Leiden, Leiden University, POB 9516, 2300 RA Leiden, The Netherlands
Comp Biochem Physiol A Mol Integr Physiol 151:37-44. 2008..As silver eels cease feeding when they start their oceanic migration, the cost of transport (COT) should be minimised and the swimming speed optimised to attain the highest energetic efficiency... - Low metabolic cost of locomotion in ornate box turtles, Terrapene ornataPeter A Zani
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
J Exp Biol 211:3671-6. 2008Evolution has produced a wide range of body plans, but for a given body mass, the energetic cost of transport (COT) of terrestrial animals falls in a relatively narrow range... - Combat ocular trauma visual outcomes during operations iraqi and enduring freedomEric D Weichel
Walter Reed Army Medical Center, Washington, District of Columbia 20307, USA
Ophthalmology 115:2235-45. 2008To report the visual and anatomic outcomes as well as to predict the visual prognosis of combat ocular trauma (COT) during Operations Iraqi and Enduring Freedom. - Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGFPrem Khanal
College of Pharmacy, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
Carcinogenesis 30:682-9. 2009..These results indicated that the Ser413 of Tpl-2 plays an important role in EGF-induced carcinogenesis as well as inactivation of the p53... - Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewesM J Zhu
Center for the Study of Fetal Programming, Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
Placenta 30:405-10. 2009..the activity of AMPK and its role in the observed down-regulation of insulin/IGF-1 signaling in cotyledonary (COT) arteries supplying the placental component of the ewe placentome... - Chronic opioid therapy and preventive services in rural primary care: an Oregon rural practice-based research network studyDavid I Buckley
Oregon Rural Practice Based Research Network, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Ann Fam Med 8:237-44. 2010..Consequent stresses on clinical encounters might adversely affect some elements of clinical care. We evaluated a possible association between chronic opioid therapy (COT) for CNCP and receipt of various preventive services. - Bonding nature and electron delocalization of An(COT)2, An = Th, Pa, UDayán Páez-Hernández
Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andrés Bello, República 275, Santiago, Chile
J Phys Chem A 115:8997-9003. 2011A systematic study of a series of An(COT)(2) compounds, where An = Th, Pa, U, and COT represents cyclooctatetraene, has been performed using relativistic density functional theory... - [N,N'-Bis(2,6-diisopropyl-phen-yl)methanimidamidato][η-1,4-bis-(tri-methyl-sil-yl)cyclo-octa-tetra-enyl](tetra-hydro-furan)-samarium(III) toluene monosolvateAnja Edelmann
Chemisches Institut der Otto von Guericke Universität, Universitatsplatz 2, D 39106 Magdeburg, Germany
Acta Crystallogr Sect E Struct Rep Online 66:m1675-6. 2010..mixture of in situ-prepared Li(DippForm) [DippFormH = N,N'-bis-(2,6-diisopropyl-phen-yl)methanimidamide] and Li(2)(COT'') [COT'' = 1,4-bis-(trimethyl-sil-yl)cyclo-octa-tetra-enyl] in tetra-hydro-furan (THF)... - Laboratory and field testing of bednet traps for mosquito (Diptera: Culicidae) sampling in West Java, IndonesiaCraig A Stoops
Navy Medical Research Unit 2, U S Embassy Jakarta, Unit 8132 NAMRU 2, FPO AP 96520 8132, Indonesia
J Vector Ecol 35:187-96. 2010..In the laboratory we tested human-baited and unbaited CDC light trap/cot bednet (CDCBN) combinations against three types of traps: the Mbita Trap (MIBITA), a Tent Trap (TENT), and a .. - FISH applications for genomics and plant breeding strategies in tomato and other solanaceous cropsD Szinay
Laboratory of Genetics, Wageningen University and Research Centre, Wageningen, The Netherlands
Cytogenet Genome Res 129:199-210. 2010..Repeat-rich areas of the chromosomes can also be demonstrated by hybridisation of probed Cot fractions of sheared genomic DNA; a powerful method to elucidate the heterochromatin domains for genomic studies... - Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiationKenjiro Bandow
Department of Oral Biochemistry, Field of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
Biochem Biophys Res Commun 402:755-61. 2010..signal-regulated kinases (ERKs), whose activation by LPS requires the upstream serine/threonine kinase, Cot/Tpl2. To determine the signal molecules responsible for the inhibitory effects of LPS on osteoblast differentiation, we .. - Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expressionMarta López-Peláez
Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
Eur J Immunol 41:1733-41. 2011..Here, we show that Cot/tpl2, a MAP3K responsible for the activation of the MKK1-Erk1/2, controls P-Ser473 Akt and P-Thr389 p70 S6k .. - Quality indicators for evaluating trauma care: a scoping reviewHenry Thomas Stelfox
Department of Critical Care Medicine, Foothills Medical Centre, University of Calgary, 1403 29 St NW, Calgary, Alberta, Canada
Arch Surg 145:286-95. 2010..To systematically review the literature on quality indicators (QIs) for evaluating trauma care, identify QIs, map their definitions, and examine the evidence base in support of the QIs... - Testing the equal environments assumption in the Children of Twins designLaura B Koenig
Family Research Center, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, USA
Behav Genet 40:533-41. 2010In a Children of Twins (COT) design, the environmental and genetic risk of a child is, in part, dependent upon the status of the father and the father's cotwin... - Involvement of Cot/Tp12 in bone loss during periodontitisT Ohnishi
Department of Developmental Medicine, Kagoshima University, Sakuragaoka, Japan
J Dent Res 89:192-7. 2010..The binding of lipopolysaccharide to Toll-like receptors causes phosphorylation of Cot/Tp12 to activate the MAPK cascade... - Operational tolerance after liver transplantationGiuseppe Orlando
Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, Headington, Oxford OX3 9DU, UK
J Hepatol 50:1247-57. 2009..While clinical operational tolerance (COT) remains the exception after other types of solid organ transplantation, several cases of COT have been described .. - Cyclic tetrathiophenes planarized by silicon and sulfur bridges bearing antiaromatic cyclooctatetraene core: syntheses, structures, and propertiesTakeshi Ohmae
Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
J Am Chem Soc 132:1066-74. 2010..1, 2, and 3 planarized by dimethylsilyl, sulfur, and sulfone bridges bearing an antiaromatic cycloocatatetraene (COT) core were designed and synthesized to investigate the relationship among the bent angle, paratropicity, and HOMO-.. - Neonatal care: time for action on the shortage of nursesAndy Cole
Bliss, London
J Fam Health Care 19:42-4. 2009..Only one in five neonatal units reported meeting the BAPM standard. Cot occupancy rates in NICUs exceeded the recommended 70% on occasions... - Airway covering during bed-sharingH Ball
Parent Infant Sleep Lab and Medical Anthropology Research Group, Department of Anthropology, Durham University, Durham, UK
Child Care Health Dev 35:728-37. 2009..To further understand the role of airway covering and compression in creating risks for bed-sharing infants, we report here on a sleep-lab trial of two infant sleep conditions... - Comparative cytogenetics of giant trahiras Hoplias aimara and H. intermedius (Characiformes, Erythrinidae): chromosomal characteristics of minor and major ribosomal DNA and cross-species repetitive centromeric sequences mapping differ among morphologicallD R Blanco
Departamento de Genetica e Evolucao, Universidade Federal de Sao Carlos, Sao Carlos, SP Brazil
Cytogenet Genome Res 132:71-8. 2011..double-staining) and fluorescent in situ hybridization (FISH) with 5S, 18S rDNA probes and cross-species Cot-1 DNA probing... - Tpl2 is a key mediator of arsenite-induced signal transductionKyung Mi Lee
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 69:8043-9. 2009Arsenite is a well-known human carcinogen that especially targets skin. The tumor progression locus 2 (Tpl2) gene encodes a serine/threonine protein kinase that is overexpressed in various cancer cells... - Time-scheduled vs. pain-contingent opioid dosing in chronic opioid therapyMichael Von Korff
Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
Pain 152:1256-62. 2011..recommend time-scheduled opioid dosing over pain-contingent dosing for patients receiving chronic opioid therapy (COT)... - Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized miceWendy T Watford
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 184:105-13. 2010The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha... - Surface-initiated ring-opening metathesis polymerization in the vapor phase: an efficient method for grafting cyclic olefins with low strain energiesMaria Felisa Z Lerum
Chemistry Department, Mount Holyoke College, South Hadley, Massachusetts 01075, United States
Langmuir 27:5403-9. 2011..CHD), cycloheptene (CHP), cis-cyclooctene (CO), cis,cis-1,5-cyclooctadiene (COD), 1,3,5,7-cyclooctatetraene (COT), cyclododecene (CD), and trans,trans,cis-1,5,9-cyclododecatriene (CDT), was explored using ring-opening metathesis .. - How does cot death prevention advice influence parents' behaviour?L H Miller
The University of Birmingham, The Medical School, Birmingham, UK
Child Care Health Dev 34:613-8. 2008To explore parents' understanding of the recommended cot death prevention strategies, and to discuss what they are doing in practice...
Research Grants
- TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic DisordersAndrew S Greenberg; Fiscal Year: 2010..Studies outlined in this grant application will test hypotheses concerning how the actions of Tumor Progression Locus 2 (TPL2), an 'upstream'mediator of inflammatory signaling, promote obesity-associated ..
- TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic DisordersAndrew Greenberg; Fiscal Year: 2009..Studies outlined in this grant application will test hypotheses concerning how the actions of Tumor Progression Locus 2 (TPL2), an 'upstream' mediator of inflammatory signaling, promote obesity-associated ..
- Tpl2 in Intestinal TumorigenesisPhilip N Tsichlis; Fiscal Year: 2010The proto-oncogene encoding the Tpl2 kinase is activated by provirus integration in retrovirus-induced rodent lymphomas and mammary adenocarcinomas...
- International Conference on Tobacco Induced DiseasesDenis Kinane; Fiscal Year: 2004..Periodontitis;12. Heart disease;13. Pregnancy complications; 14. Sudden Infant Death Syndrome (Cot Death); 15. Birth Defects Treatment: 15. Molecular biology of cancer/xenobiotics gene polymorphisms; 16...
- Regulation of the Tp12 KinasePhilip Tsichlis; Fiscal Year: 2009..Overexpression of Tpl2 in a variety of cell types activates ERK, JNK, p38 MAPK, and the transcription factors NF-AT and NF-KB...
- ROLE OF TPL-2, CYCLIN D1 AND TOUVLO IN BREAST CANCERChristos Patriotis; Fiscal Year: 2002..The obtained result will enhance our understanding of the growth regulation of normal and neoplastic mammary epithelia and may identify molecular markers for diagnosis and therapeutic intervention. ..
- Proteomics of M-L antigens modulating cation transportPETER LAUF; Fiscal Year: 2004..These sheep red blood cell (SRBC) proteins are functionally associated with the Na/K pump and K-CI cotransporter (COT)...
- INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTORRadhakrishna Rao; Fiscal Year: 2007..translocation of PP2A to the tight junction by c-Src dependent mechanism, 5) expression of dominant negative PP2A-Cot and reduced expression by antisense oligos prevent oxidative stress-induced disruption of the tight junction, 6) ..
- The IKK/Tpl2 axis of TLR signalingShao Cong Sun; Fiscal Year: 2010..Over the past few years, we have made seminal findings demonstrating a pivotal TLR signaling axis: the IKK/Tpl2 axis...
- ROLE OF TVI 1 IN APOPTOSISPhilip Tsichlis; Fiscal Year: 2004..This application addresses the role of Tvl-1 in the assembly and function of such complexes. ..
- Offspring of Twins: G,E and GxE Risks for AlcoholismTheodore Jacob; Fiscal Year: 2009..Our approach is distinguished by two significant design characteristics: (1) use of the powerful children of twins (COT) design involving twins in the parent generation who are concordant or discordant for alcohol dependence (and ..
- ACTIVATION OF IKB KINASE BY HTLV-I TAXShao Cong Sun; Fiscal Year: 2003..Interestingly, one of the putative IKK upstream kinases, Cot, physically interacts with Tax...
- The IKK/Tpl2 axis of TLR signalingShao Cong Sun; Fiscal Year: 2011..Over the past few years, we have made seminal findings demonstrating a pivotal TLR signaling axis: the IKK/Tpl2 axis...