Gene Symbol: MAP1A
Description: microtubule associated protein 1A
Alias: MAP1L, MTAP1A, microtubule-associated protein 1A, MAP-1A, proliferation-related protein p80
Species: human
Products:     MAP1A

Top Publications

  1. Bloom G, Luca F, Vallee R. Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules. J Cell Biol. 1984;98:331-40 pubmed
    ..protein 1 (MAP 1) from brain comprises multiple protein species, and that the principal component, MAP 1A, can be detected in both neuronal and glial cells by immunofluorescence microscopy using a monoclonal antibody...
  2. Fukuyama R, Rapoport S. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. J Neurosci Res. 1995;40:820-5 pubmed
    ..A 1,570 bp sequence of one cDNA fragment showed 75% homology to the rat microtubule-associated protein 1A (MAP1A) cDNA sequence...
  3. Mei X, Sweatt A, Hammarback J. Regulation of microtubule-associated protein 1B (MAP1B) subunit composition. J Neurosci Res. 2000;62:56-64 pubmed
    The MAP1B and MAP1A genes each produce an mRNA that encodes a polyprotein. When cleaved, each polyprotein yields a single heavy chain and a single light chain, which become noncovalently associated...
  4. Jiang X, Zhong W, Huang H, He H, Jiang F, Chen Y, et al. Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients. Mol Carcinog. 2015;54:1194-204 pubmed publisher
    MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation...
  5. Fernandez J, Portilho D, Danckaert A, Munier S, Becker A, Roux P, et al. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. J Biol Chem. 2015;290:4631-46 pubmed publisher
    ..screen, we identified four cytoskeletal components as putative interaction partners for HIV-1 p24 capsid protein: MAP1A, MAP1S, CKAP1, and WIRE...
  6. Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, et al. Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J. 2017;31:3349-3358 pubmed publisher
    ..These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A, induces reduction of Otx2 expression, increases prenatal cell death, and accordingly leads to selective loss of ..
  7. Waaijers S, Muñoz J, Berends C, Ramalho J, Goerdayal S, Low T, et al. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biol. 2016;14:66 pubmed publisher
    ..specifically with DLG-1 purified from neurons, and shared limited homology with the microtubule-associated protein MAP1A, a known neuronal interaction partner of mammalian DLG4/PSD95. A CRISPR/Cas9-engineered GFP::MAPH-1...
  8. Johnston C, Doe C, Prehoda K. Structure of an enzyme-derived phosphoprotein recognition domain. PLoS ONE. 2012;7:e36014 pubmed publisher
    ..Mutational analysis reveals that the GBD is also used to bind the GK ligand MAP1a, suggesting that this is a common mode of MAGUK complex assembly...
  9. Song K, Hu W, Yue F, Zou J, Li W, Chen Q, et al. Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas. PLoS ONE. 2015;10:e0143150 pubmed publisher
    ..protein MAP1S (originally named C19ORF5) is a widely-distributed homologue of neuronal-specific MAP1A and MAP1B with which autophagy marker light chain 3 (LC3) was originally co-purified...

More Information


  1. Eicher J, Chami N, Kacprowski T, Nomura A, Chen M, Yanek L, et al. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016;99:40-55 pubmed publisher
    ..the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants...
  2. Friedrichs P, Schlotterer A, Sticht C, Kolibabka M, Wohlfart P, Dietrich A, et al. Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model. Diabetologia. 2017;60:1354-1358 pubmed publisher
    ..regulated genes in the cytoskeletal compartment were Ddx51, Fgd4, Pdlim7, Utp23, Cep57, Csrp3, Eml5, Fhl3, Map1a, Mapk1ip1, Mnda, Neil2, Parp2, Myl12b, Dynll1, Stag3 and Sntg2, and in the nuclear compartment were Ddx51, Utp23, ..
  3. Chami N, Chen M, Slater A, Eicher J, Evangelou E, Tajuddin S, et al. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016;99:8-21 pubmed publisher
    ..We found low-frequency missense variants in MAP1A (rs55707100, minor allele frequency [MAF] = 3...
  4. Tzekov R, Dawson C, Orlando M, Mouzon B, Reed J, Evans J, et al. Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury. PLoS ONE. 2016;11:e0153608 pubmed publisher
    ..proteins, including neurofilaments (NEFH, NEFM, NEFL), tubulin (TUBB2A, TUBA4A), microtubule-associated proteins (MAP1A, MAP1B), collagen (COL6A1, COL6A3) and increased expression of other proteins, including heat shock proteins (..
  5. Schoenfeld T, McKerracher L, Obar R, Vallee R. MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. J Neurosci. 1989;9:1712-30 pubmed
    ..1984). These proteins were termed MAP 1A, 1B, 1C, 2A, and 2B...
  6. Magiera M, Gupta M, Rundell C, Satish N, Ernens I, Yarwood S. Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. Biochem J. 2004;382:803-10 pubmed bait in two-hybrid screens of foetal and adult human brain libraries, we identified the LC2 (light chain 2) of MAP1A (microtubule-associated protein 1A) as a protein capable of interaction with EPAC1...
  7. Lajoie Mazenc I, Tovar D, Penary M, Lortal B, Allart S, Favard C, et al. MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. J Biol Chem. 2008;283:4155-64 pubmed
    ..glutathione S-transferase pulldown assay, we identified LC2, the light chain of the microtubule-associated protein MAP1A, as a novel binding partner for RhoB...
  8. Takei Y, Kikkawa Y, Atapour N, Hensch T, Hirokawa N. Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J Neurosci. 2015;35:15539-54 pubmed publisher
    Microtubule-associated protein 1A (MAP1A) is a member of the major non-motor microtubule-binding proteins...
  9. Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, et al. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. J Biol Chem. 2001;276:12839-48 pubmed
    ..assays, we have tested the ability of polyglutamylation to modulate the interaction of two other structural MAPs, MAP1A and MAP1B, with tubulin...
  10. Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, et al. Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins. J Biol Chem. 2001;276:31340-8 pubmed
  11. Snasel J, Pichova I. The cleavage of host cell proteins by HIV-1 protease. Folia Biol (Praha). 1996;42:227-30 pubmed
  12. Ikeda A, Zheng Q, Zuberi A, Johnson K, Naggert J, Nishina P. Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nat Genet. 2002;30:401-5 pubmed
    ..experiment, we verified that sequence polymorphisms in the neuron-specific microtubule-associated protein 1a gene (Mtap1a) observed in the susceptible strain C57BL/6J (B6) are crucial for the hearing-loss phenotype...
  13. Morris J, Kandpal G, Ma L, Austin C. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet. 2003;12:1591-608 pubmed assays with multiple proteins of the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin2 and beta4-spectrin; and ..
  14. Longhurst D, Watanabe M, Rothstein J, Jackson M. Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. J Biol Chem. 2006;281:12030-40 pubmed
    ..This coordinated action of the actin and microtubular cytoskeletons is essential for the development and maintenance of neuronal polarity. ..
  15. Maurer M, Grünewald S, Gassler N, Rossner M, Propst F, Wurz R, et al. Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. J Neurochem. 2004;91:1007-17 pubmed
    ..Coupling to MAP1a has been described for another cognate GPCR, the 5-hydroxytryptamine (5HT) 2a receptor...
  16. Gupta M, Yarwood S. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion. J Biol Chem. 2005;280:8109-16 pubmed
    We have recently demonstrated that light chain 2 (LC2) of the microtubule-associated protein MAP1A interacts with the cyclic AMP (cAMP)-binding domain of exchange protein directly activated by cyclic AMP 1 (EPAC1)...
  17. Tretyakova I, Zolotukhin A, Tan W, Bear J, Propst F, Ruthel G, et al. Nuclear export factor family protein participates in cytoplasmic mRNA trafficking. J Biol Chem. 2005;280:31981-90 pubmed
    ..We propose a model in which MAP1B tethers the NXF-associated mRNA to microtubules and facilitates their translocation along dendrites while Unrip provides a scaffold for the assembly of these transport intermediates. ..
  18. So J, Kim J, Yoo K, Kim H, Jung S, Choi J, et al. FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development. PLoS ONE. 2014;9:e109517 pubmed publisher
    ..Taken together, our data suggest that FIH-1 interacts with Mib E3 Ubiquitin ligase and modulates vascular development by attenuating VEGF-A signaling activity. ..
  19. Noiges R, Stroissnigg H, Trancikova A, Kalny I, Eichinger R, Propst F. Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains. Biochim Biophys Acta. 2006;1763:1011-6 pubmed
    The microtubule-associated proteins MAP1A and MAP1B are related but distinct multi-subunit protein complexes that consist of heavy and light chains. The predominant forms of these complexes are homotypic, i.e...
  20. Xia Y, Shang Y, Zhang R, Zhu J. Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain. Biochem J. 2017;474:2817-2828 pubmed publisher
    ..bind to a peptide sequence within the C-terminal region of neuronal-specific microtubule-associated protein 1A (MAP1A), although the detailed molecular mechanism governing this phosphorylation-independent interaction at the atomic ..
  21. Nakayama A, Murakami H, Maeyama N, Yamashiro N, Sakakibara A, Mori N, et al. Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. J Biol Chem. 2003;278:233-40 pubmed
    Microtubule-associated protein MAP1A is expressed abundantly in mature neurons and is necessary for maintenance of neuronal morphology and localization of some molecules in association with the microtubule-based cytoskeleton...
  22. Noiges R, Eichinger R, Kutschera W, Fischer I, Nemeth Z, Wiche G, et al. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. J Neurosci. 2002;22:2106-14 pubmed
    The microtubule-associated proteins 1A (MAP1A) and 1B (MAP1B) are distantly related protein complexes consisting of heavy and light chains and are thought to play a role in regulating the neuronal cytoskeleton, MAP1B during ..
  23. Ulfig N, Feldhaus C, Setzer M, Bohl J. Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain. Neurosci Res. 2000;38:397-405 pubmed
    The expression of microtubule-associated proteins 1a and 1b (MAP1a and 1b) were investigated in two transient structures, the ganglionic eminence (GE) being a prominent part of the telencephalic proliferative zone and the perireticular ..
  24. Mann S, Hammarback J. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem. 1994;269:11492-7 pubmed
    Light chain 3 (LC3) is a subunit of the neuronal microtubule-associated proteins (MAPs), MAP1A and MAP1B...
  25. Park S, Liu G, Kubal A, Fury M, Cao L, Marx S. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. FEBS Lett. 2004;570:143-8 pubmed
    ..Here, we report that the BKCa channel physically interacts with the light chain of microtubule associated protein 1A (MAP1A). The light chain was isolated in a yeast two-hybrid screen of a human brain cDNA library...
  26. Vaillant A, Muller R, Langkopf A, Brown D. Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics. J Biol Chem. 1998;273:13973-81 pubmed
    To determine how MAP1a interacts with microtubules we expressed several 6myc-tagged MAP1a fragments in P19 EC and HeLa cells...
  27. Fink J, Jones S, Esposito C, Wilkowski J. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. Genomics. 1996;35:577-85 pubmed
    ..b>MAP1a (HGMW-approved symbol MAP1A) stabilizes microtubules in postnatal axons...
  28. Liu Y, Lee J, Ackerman S. Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration. J Neurosci. 2015;35:4587-98 pubmed publisher
    ..Microtubule-associated protein 1A (MAP1A) is one of the most abundantly expressed MAPs in the mammalian brain...
  29. Wallin M, Deinum J, Goobar L, Danielson U. Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases. J Gen Virol. 1990;71 ( Pt 9):1985-91 pubmed
    ..It is suggested that proteolysis of microtubular proteins by viral proteinases is an important step in viral pathogenicity and that it may be part of a mechanism causing degenerative effects in infected cells. ..
  30. Fujii T, Watanabe M, Ogoma Y, Kondo Y, Arai T. Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro. J Biochem. 1993;114:827-9 pubmed
    Microtubule-associated protein (MAP) 1 consisting of MAP 1A and 1B was purified from rat brain by the poly-L-aspartic acid (PLAA) method. We found that MAP 1 bound to F-actin in vitro up to a molar ratio of MAP 1 to actin monomers of 1:10...
  31. Cornea Hébert V, Watkins K, Roth B, Kroeze W, Gaudreau P, Leclerc N, et al. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat. Neuroscience. 2002;113:23-35 pubmed
    ..results suggesting an association of 5-HT(2A) receptors with the cytoskeletal microtubule-associated protein MAP1A, the respective subcellular distributions of the receptors and of MAP1A were compared by quantitative electron ..
  32. Sheffler D, Kroeze W, Garcia B, Deutch A, Hufeisen S, Leahy P, et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 2006;103:4717-22 pubmed
    ..Because RSK2-inactivating mutations in humans lead to Coffin-Lowry syndrome, our results imply that alterations in GPCR signaling may account for some of its clinical manifestations...
  33. Brenman J, Topinka J, Cooper E, McGee A, Rosen J, Milroy T, et al. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998;18:8805-13 pubmed vivo interaction of PSD-93 via its guanylate kinase (GK) domain with microtubule-associated protein 1A (MAP1A)...
  34. Hirst J, Lui W, Bright N, Totty N, Seaman M, Robinson M. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. J Cell Biol. 2000;149:67-80 pubmed
    ..These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome. ..
  35. Pedrotti B, Colombo R, Islam K. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein. Cell Motil Cytoskeleton. 1994;29:110-6 pubmed
    High molecular weight microtubule-associated proteins MAP1A and MAP2 form thin projections from microtubule surfaces and have been implicated in crosslinking microtubules and other cytoskeletal components...
  36. Lien L, Feener C, Fischbach N, Kunkel L. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. Genomics. 1994;22:273-80 pubmed
    ..with the sequence databases, we have identified a MAP1B-related gene that is probably the human homologue of rat MAP1A. This gene is expressed at high levels in brain and spinal cord and much lower levels in muscle and maps to the ..
  37. Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio Henriksson A, Suvisaari J, et al. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry. 2009;65:1055-62 pubmed publisher
    ..Our findings with other converging lines of evidence support the underlying importance of DISC1-related molecular pathways in the etiology of schizophrenia and other major mental illnesses. ..