Gene Symbol: MAOB
Description: monoamine oxidase B
Alias: amine oxidase [flavin-containing] B, MAO, brain, MAO, platelet, MAO-B, adrenalin oxidase, monoamine oxidase type B, tyramine oxidase
Species: human
Products:     MAOB

Top Publications

  1. Tan E, Chai A, Lum S, Shen H, Tan C, Teoh M, et al. Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:58-62 pubmed
    Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the MAO B gene may modify the relationship between smoking and Parkinson's Disease (PD)...
  2. Białecka M, Drozdzik M, Honczarenko K, Gawronska Szklarz B, Stankiewicz J, Dabrowska E, et al. Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population. Eur Neurol. 2005;53:68-73 pubmed
    ..It has been suggested that polymorphisms in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might increase the risk of PD...
  3. Hernán M, Checkoway H, O Brien R, Costa Mallen P, De Vivo I, Colditz G, et al. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology. 2002;58:1381-7 pubmed
    A polymorphism (G to A transition) in intron 13 of the mitochondrial enzyme monoamine oxidase B (MAOB) gene may modify, alone or by interacting with the catechol-O-methyltransferase (COMT(LL)) genotype (low enzymatic activity), the risk ..
  4. Gasso P, Bernardo M, Mas S, Crescenti A, Garcia C, Parellada E, et al. Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population. Neuropsychobiology. 2008;58:65-70 pubmed publisher
    ..Our results support the involvement of the MAO-B gene in schizophrenia, particularly in women. ..
  5. Dlugos A, Palmer A, de Wit H. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. J Neural Transm (Vienna). 2009;116:1323-34 pubmed publisher
    Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect...
  6. Grimsby J, Chen K, Wang L, Lan N, Shih J. Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci U S A. 1991;88:3637-41 pubmed
    Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3...
  7. Wyatt R, Murphy D, Belmaker R, Cohen S, Donnelly C, Pollin W. Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Science. 1973;179:916-8 pubmed
    ..These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia. ..
  8. Fowler J, Volkow N, Wang G, Pappas N, Logan J, MacGregor R, et al. Inhibition of monoamine oxidase B in the brains of smokers. Nature. 1996;379:733-6 pubmed
    ..Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC relative to non-smokers or former smokers...
  9. Checkoway H, Franklin G, Costa Mallen P, Smith Weller T, Dilley J, Swanson P, et al. A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease. Neurology. 1998;50:1458-61 pubmed
    ..These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism. ..

More Information

Publications155 found, 100 shown here

  1. Wu R, Cheng C, Chen K, Lu S, Shan D, Ho Y, et al. The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology. 2001;56:375-82 pubmed
    Reports suggest that catechol-O-methyltransferase (COMT(L/L)) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD...
  2. Kelada S, Costa Mallen P, Costa L, Smith Weller T, Franklin G, Swanson P, et al. Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease. Neurotoxicology. 2002;23:515-9 pubmed
    ..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD. ..
  3. Filic V, Vladic A, Stefulj J, Cicin Sain L, Balija M, Sucic Z, et al. Monoamine oxidases A and B gene polymorphisms in migraine patients. J Neurol Sci. 2005;228:149-53 pubmed
    ..The suggestive association of the variant in MAO-A gene with migraine is considered worthy of independent replication. On the other hand, further studies on MAO-B polymorphism in migraine do not seem promising. ..
  4. Singh M, Khan A, Shah P, Shukla R, Khanna V, Parmar D. Polymorphism in environment responsive genes and association with Parkinson disease. Mol Cell Biochem. 2008;312:131-8 pubmed publisher
    ..on their corresponding loci revealed that four combinations of GSTT1 null and MnSOD(-9Val) or GST null and MAOB-G or CYP2E1*5B and MAO-B-AG or CYP2E1*5B and DRD2 (Taq1A-het) genotypes in the patients exhibited severalfold ..
  5. Carrera N, Sanjuan J, Molto M, Carracedo A, Costas J. Recent adaptive selection at MAOB and ancestral susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:369-74 pubmed publisher
    ..In order to test this hypothesis in schizophrenia, we focused on the monoamine oxidase B gene (MAOB)...
  6. Gu Z, Feng X, Dong X, Chan P. Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. Neurosci Lett. 2010;482:31-4 pubmed publisher
    ..Our data support a reduction of PD risk associated with smoking in a Chinese population. These variants of genes associated with DA uptake and metabolism do not affect the inverse association between smoking and PD. ..
  7. Bortolato M, Shih J. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. Int Rev Neurobiol. 2011;100:13-42 pubmed publisher
  8. Wong W, Chen K, Shih J. Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem. 2003;278:36227-35 pubmed
    ..Here we show that MAO B, but not MAO A, gene expression was induced during Caco-2 cell differentiation; thus this cell line was used as a ..
  9. Zammit S, Jones G, Jones S, Norton N, Sanders R, Milham C, et al. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;128B:19-20 pubmed
    ..We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia...
  10. Pivac N, Knezevic J, Mustapic M, Dezeljin M, Muck Seler D, Kozaric Kovacic D, et al. The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. Life Sci. 2006;79:45-9 pubmed
  11. De Palma G, Dick F, Calzetti S, Scott N, Prescott G, Osborne A, et al. A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions. Mov Disord. 2010;25:912-9 pubmed publisher
    ..CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA...
  12. Li S, Villeneuve D, Berninger J, Blackwell B, Cavallin J, Hughes M, et al. An integrated approach for identifying priority contaminant in the Great Lakes Basin - Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern. Sci Total Environ. 2017;579:825-837 pubmed publisher
    ..receptor alpha1 (esr1), chemokine ligand 10 protein (CXCL10), tumor protein p53 (p53), and monoamine oxidase B (Maob), were identified as candidates for future assessments at these AOCs...
  13. Ou X, Chen K, Shih J. Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene. J Biol Chem. 2004;279:21021-8 pubmed
    ..Abnormal expression of MAO has been implicated in several psychiatric and neurodegenerative disorders. Human MAO B core promoter (-246 to -99 region) consists of CACCC element flanked by two clusters of overlapping Sp1 sites...
  14. Scott W, Zhang F, Stajich J, Scott B, Stacy M, Vance J. Family-based case-control study of cigarette smoking and Parkinson disease. Neurology. 2005;64:442-7 pubmed
    ..This association was detected even though discordant sibling pairs are more likely to be overmatched for environmental exposures than unmatched case and control groups. ..
  15. Clarke M, Russell P, Zajac J, Davey R. The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice. J Steroid Biochem Mol Biol. 2019;189:187-194 pubmed publisher
    ..05) in Hyp-ARKO male mice and was associated with a reduction in gene expression of Drd1a and Maob (P ≤ 0.05) in the hypothalamus, suggesting involvement of the brain dopaminergic system...
  16. Parsian A, Racette B, Zhang Z, Rundle M, Perlmutter J. Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups. Genomics. 2004;83:454-60 pubmed
    ..The frequency of common haplotypes from MAO-A and -B was different in PD and control group (p = 0.02). Our data indicate that MAO-A and -B may play a role in susceptibility to PD in our sample. ..
  17. Hirayama Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, et al. Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics. J Proteomics. 2017;158:31-42 pubmed publisher
    ..Targeted proteomics revealed that GRIK4 and MAOB were significantly decreased among 125 putatively schizophrenia-related proteins in prefrontal cortex of ..
  18. Jiang H, Jiang Q, Liu W, Feng J. Parkin suppresses the expression of monoamine oxidases. J Biol Chem. 2006;281:8591-9 pubmed
    ..This function may limit the production of reactive oxygen species generated by MAO in dopamine oxidation and would, thus, be beneficial to the survival of dopaminergic neurons. ..
  19. Youdim M. Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases. J Neural Transm (Vienna). 2018;125:1719-1733 pubmed publisher
    In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine...
  20. Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, et al. Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. BMC Neurol. 2011;11:89 pubmed publisher
    ..We investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 polymorphisms and PD risk with special attention to the interaction with ..
  21. Cui Y, Liu K, Liang Y, Ip M, Mak J. Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells. Toxicol Lett. 2017;268:44-50 pubmed publisher
    ..Our study demonstrated that in AECs, inhibition of MAO-B using selegiline reversed the CSM-induced oxidative stress and inflammation. These data may provide a novel strategy for therapy in COPD. ..
  22. Karmakar A, Goswami R, Saha T, Maitra S, Roychowdhury A, Panda C, et al. Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands. BMC Med Genet. 2017;18:109 pubmed publisher
    ..Monoamine oxidase A (MAOA) and B (MAOB), mitochondrial outer membrane bound two isoenzymes, mediate degradation of these neurotransmitters and thus ..
  23. Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih J, et al. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience. 1996;70:755-74 pubmed
    ..The combination of quantitative enzyme radioautography with in situ hybridization histochemistry is a useful approach to study, with high resolution, both the physiology and pathophysiology of monoamine oxidases in human brain. ..
  24. Chakraborti B, Verma D, Karmakar A, Jaiswal P, Sanyal A, Paul D, et al. Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:123-36 pubmed publisher
    ..Therefore, genes encoding monoamine oxidases A/B (MAOA/MAOB) received special attention as these genes are located on the X-chromosome and the gene products are responsible ..
  25. Sun W, Choi J, Cha Y, Koo J. Evaluation of the Expression of Amine Oxidase Proteins in Breast Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..staining of amine oxidase proteins (LOX, lysyl oxidase, AOC3, amine oxidase, MAOA, monoamine oxidase A, MAOB, monoamine oxidase B)...
  26. Karolewicz B, Klimek V, Zhu H, Szebeni K, Nail E, Stockmeier C, et al. Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei. Brain Res. 2005;1043:57-64 pubmed
    ..The amount of MAO-B binding positively correlated with the age of subjects in all nuclei investigated. A decreased amount of MAO-B in smokers further validates the pharmacological effect of tobacco smoke on this enzyme. ..
  27. Gardner M, Bertranpetit J, Comas D. Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1070-5 pubmed publisher
    ..A list of tagSNPs per gene and continental region is proposed providing a guide for future association studies with these genes. ..
  28. Kang S, Park Y, Choi J, Lim S, Lee H, Lee S, et al. Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia. Hum Psychopharmacol. 2010;25:397-403 pubmed publisher
    ..for the variable number of tandem repeat (VNTR) polymorphism of the MAOA gene and A644G polymorphism of the MAOB gene...
  29. Lenders J, Eisenhofer G, Abeling N, Berger W, Murphy D, Konings C, et al. Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes. J Clin Invest. 1996;97:1010-9 pubmed
    ..The differences in neurochemical profiles indicate that, under normal conditions, MAO-A is considerably more important than MAO-B in the metabolism of biogenic amines, a factor likely to contribute to the different clinical phenotypes. ..
  30. Takehashi M, Tanaka S, Masliah E, Ueda K. Association of monoamine oxidase A gene polymorphism with Alzheimer's disease and Lewy body variant. Neurosci Lett. 2002;327:79-82 pubmed
    The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined...
  31. Oporto G, Bornhardt T, Iturriaga V, Salazar L. Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism. Clin Oral Investig. 2018;22:331-337 pubmed publisher
    ..of single nucleotide polymorphisms (SNPs) in dopaminergic pathway genes (DRD1, DRD2, DRD3, DRD4, DRD5, and MAOB) in patients undergoing bruxism treatment and controls...
  32. Zubkov E, Zorkina Y, Orshanskaya E, Khlebnikova N, Krupina N, Chekhonin V. Changes in Gene Expression Profiles in Adult Rat Brain Structures after Neonatal Action of Dipeptidyl Peptidase-IV Inhibitors. Neuropsychobiology. 2017;76:89-99 pubmed publisher
    ..4.21.26; dpp4 and prep genes), monoamine oxidase ? (maoA) and B (maoB), and serotonin transporter (SERT; sert) in the brain structures from 3-month-old rats after postnatal action of ..
  33. Ito H, Hamajima N, Matsuo K, Okuma K, Sato S, Ueda R, et al. Monoamine oxidase polymorphisms and smoking behaviour in Japanese. Pharmacogenetics. 2003;13:73-9 pubmed
    ..These findings among male smokers support the view that MAO affects a smokers' requirement for nicotine and may explain why some people are predisposed to tobacco addiction and why some individuals find it difficult to stop smoking. ..
  34. Hubalek F, Pohl J, Edmondson D. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. J Biol Chem. 2003;278:28612-8 pubmed
    ..Human MAO A and MAO B each contain 9 cysteine residues (7 in conserved sequence locations)...
  35. McGregor N, Hemmings S, Erdman L, Calmarza Font I, Stein D, Lochner C. Modification of the association between early adversity and obsessive-compulsive disorder by polymorphisms in the MAOA, MAOB and COMT genes. Psychiatry Res. 2016;246:527-532 pubmed publisher
    ..pilot study investigated gene-by-environment interactions between childhood trauma and polymorphisms in the MAOA, MAOB and COMT genes in OCD...
  36. Dick F, De Palma G, Ahmadi A, Osborne A, Scott N, Prescott G, et al. Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study. Occup Environ Med. 2007;64:673-80 pubmed
    ..There was insufficient evidence that the other gene-environment combinations investigated modified disease risk, suggesting they contribute little to the burden of PD. ..
  37. Nedic G, Pivac N, Hercigonja D, Jovancevic M, Curkovic K, Muck Seler D. Platelet monoamine oxidase activity in children with attention-deficit/hyperactivity disorder. Psychiatry Res. 2010;175:252-5 pubmed publisher
    ..In line with hypotheses of lower platelet MAO activity in different types of psychopathology, children with different subtypes of ADHD had significantly lower platelet MAO-B activity than control children. ..
  38. Nikolac Perkovic M, Nedic Erjavec G, Stefulj J, Muck Seler D, Pivac N, Kocijan Hercigonja D, et al. Association between the polymorphisms of the selected genes encoding dopaminergic system with ADHD and autism. Psychiatry Res. 2014;215:260-1 pubmed publisher
  39. Zhang Y, Piao X, Wu J, Li Y, Liang Q. A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. Int J Neurosci. 2016;126:400-7 pubmed publisher
    To date, many studies have examined the correlation between Monoamine oxidase B (MAOB) intron 13 A/G polymorphisms and the susceptibility to Parkinson's disease (PD). However, the results of these studies are inconclusive...
  40. Salilew Wondim D, Ibrahim S, Gebremedhn S, Tesfaye D, Heppelmann M, Bollwein H, et al. Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile. BMC Genomics. 2016;17:218 pubmed publisher
    ..INHBA, DAPL1 and SERPINA1 were significantly upregulated, whereas the expression level of 111 genes including MAOB, CXCR4, HSD11B and, BOLA, were significantly downregulated in CE compared to the HE animal group...
  41. Cruz Monteagudo M, Borges F, Cordeiro M, Helguera A, Tejera E, Paz y Mino C, et al. Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold. Curr Neuropharmacol. 2017;15:1117-1135 pubmed publisher
    ..similarity graphs and molecular docking studies support the suitability of the chromone nucleus as a potential MAOB/ A2AAR dual binding scaffold...
  42. Denney R, Fritz R, Patel N, Abell C. Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody. Science. 1982;215:1400-3 pubmed
    ..These results support the hypothesis that there is an intrinsic structural difference between monoamine oxidase A and B and demonstrate that immunoaffinity chromatography can physically resolve the two enzyme species in liver extracts. ..
  43. Paaver M, Nordquist N, Parik J, Harro M, Oreland L, Harro J. Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing. Psychopharmacology (Berl). 2007;194:545-54 pubmed
    ..The two markers of lower serotonergic capacity, 5-HTTLPR S allele and low platelet MAO activity, have a similar and partly synergistic influence on self-reported as well as performance measures of impulsivity. ..
  44. Richards G, Messer J, Waldvogel H, Gibbons H, Dragunow M, Faull R, et al. Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography. Brain Res. 2011;1370:204-14 pubmed publisher
    ..Moreover, it remains to be seen if selective enzyme inhibitors have therapeutic utility in the treatment of HD by reducing oxidative stress locally. ..
  45. Edmondson D, Binda C, Mattevi A. The FAD binding sites of human monoamine oxidases A and B. Neurotoxicology. 2004;25:63-72 pubmed
    ..details of the interactions of the covalent 8alpha-S-cysteinyl-FAD with the protein moiety in monoamine oxidase B (MAO B) based on the MAO B crystal structure are described...
  46. Bergen S, Fanous A, Walsh D, O Neill F, Kendler K. Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features. Schizophr Res. 2009;109:94-7 pubmed publisher
    We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom ..
  47. Binda C, Newton Vinson P, Hubalek F, Edmondson D, Mattevi A. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol. 2002;9:22-6 pubmed
    Monoamine oxidase B (MAO B) is a mitochondrial outermembrane flavoenzyme that is a well-known target for antidepressant and neuroprotective drugs. We determined the structure of the human enzyme to 3 A resolution...
  48. Kumar M, Nicholls D, Andersen J. Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease. J Biol Chem. 2003;278:46432-9 pubmed
    ..Our data suggest that H2O2 production via subtle elevations in MAO-B levels can result in oxidative effects on KGDH that can compromise the ability of dopaminergic neurons to cope with increased energetic stress. ..
  49. Chen Q, Xu Y, Zhang H, Tan X, Liu S, Yan F. Immunocytochemical Localization of Monoamine Oxidase Type B in Rat's Peripheral Nervous System. J Biochem Mol Toxicol. 2015;29:521-5 pubmed publisher
    Immunohistochemistry is used to investigate subcellular localization of monoamine oxidase type B (MAOB) in the axon of the rat's peripheral nervous system...
  50. Chu Q, Liang T, Fu L, Li H, Zhou B. Behavioural genetic differences between Chinese and European pigs. J Genet. 2017;96:707-715 pubmed
    ..05) between Mi and LLW. The most frequent haplotypes were different in DBH, HTR2A, GAD1, HTR2B,MAOA and MAOB genes between Mi and LLW. The mean of backtest scores was significantly lower (P < 0.001) for Mi than LLW pigs...
  51. Johnstone E, Clark T, Griffiths S, Murphy M, Walton R. Polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers: seeking confirmation of the association in a follow-up study. Pharmacogenetics. 2002;12:585-7 pubmed
  52. Binda C, Li M, Hubalek F, Restelli N, Edmondson D, Mattevi A. Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A. 2003;100:9750-5 pubmed
    ..Small conformational changes are observed on comparison of the different inhibitor-enzyme complexes. Future MAO-B drug design will need to consider "induced fit" contributions as an element in ligand-enzyme interactions. ..
  53. Tong J, Rathitharan G, Meyer J, Furukawa Y, Ang L, Boileau I, et al. Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders. Brain. 2017;140:2460-2474 pubmed publisher
    ..The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson's disease...
  54. Shao M, Liu Z, Tao E, Chen B. [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001;18:122-4 pubmed
    ..The high activity A or AA genotype of MAO-B and the low activity genotype of NQO1 gene might have synergistic effect. When both genotypes coexist, the risk of suffering PD will be increased greatly. ..
  55. Zhu H, Piletz J. Association between I(2) binding sites and monoamine oxidase-B activity in platelets. Ann N Y Acad Sci. 2003;1009:347-52 pubmed
    ..61, P = 0.0016) among 24 human subjects. Nevertheless, the variance in MAO-B activity cannot be completely accounted for in relation to I(2) sites. Therefore, I(2) density and MAO-B activity are only weakly correlated in platelets. ..
  56. Cesura A, Gottowik J, Lahm H, Lang G, Imhof R, Malherbe P, et al. Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur J Biochem. 1996;236:996-1002 pubmed
    ..Conversely, substitution of Lys386 (to Met) and Ser394 (to Ala) did not markedly modify the kinetic properties of the enzyme. We also report that mutation of MAO-B Thr158 (to Ala) resulted in a dramatic loss of enzymic activity. ..
  57. Costa Mallen P, Afsharinejad Z, Kelada S, Costa L, Franklin G, Swanson P, et al. DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls. Mov Disord. 2004;19:76-83 pubmed
    ..No commonly occurring (>10%) polymorphisms were found in the exons or the intronic sequences flanking the exons, although several rare variants were detected in the coding and promoter regions. ..
  58. MacMillar S, Edmondson D, Matsson O. Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted. J Am Chem Soc. 2011;133:12319-21 pubmed publisher
    ..Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-(2)H(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom. ..
  59. Binda C, Mattevi A, Edmondson D. Structural properties of human monoamine oxidases A and B. Int Rev Neurobiol. 2011;100:1-11 pubmed publisher
    ..Dimerization may be important for the favorable orientation of the resultant protein dipole moment toward the anionic membrane surface. ..
  60. Čugura T, Boh J, Zupanc T, Pregelj P, Videtič Paska A. Differences in SNP genotype distributions between complex and simple suicides. Int J Legal Med. 2018;132:1595-1601 pubmed publisher
    ..4% for rs909525 and T 25.8% for rs1137070. The distribution analysis of polymorphism rs1799836 in the MAOB gene and all studied polymorphisms in the MAOA gene in females failed to show any significant results...
  61. Hranilovic D, Bujas Petkovic Z, Tomicic M, Bordukalo Niksic T, Blazevic S, Cicin Sain L. Hyperserotonemia in autism: activity of 5HT-associated platelet proteins. J Neural Transm (Vienna). 2009;116:493-501 pubmed publisher
    ..have measured the activity of two platelet 5HT-associated proteins: 5HT transporter (5HTT) and monoamine oxidase B (MAOB), and indirectly studied the activity of 5HT(2A) receptor (5HT(2A)r) in 15 hyperserotonemic (HS) and 17 ..
  62. Laurencin C, Danaila T, Broussolle E, Thobois S. Initial treatment of Parkinson's disease in 2016: The 2000 consensus conference revisited. Rev Neurol (Paris). 2016;172:512-523 pubmed publisher
    ..agonists (DAs), catechol-O-methyltransferase inhibitors (COMT-Is), anticholinergics, monoamine oxidase inhibitors (MAOB-Is) and amantadine have been considered, and their efficacy and safety for both motor as well as non-motor aspects ..
  63. Moreno Viedma V, Amor M, Sarabi A, Bilban M, Staffler G, Zeyda M, et al. Common dysregulated pathways in obese adipose tissue and atherosclerosis. Cardiovasc Diabetol. 2016;15:120 pubmed publisher
    ..with Il7r, C3ar1, Tlr1, Rgs1 and Semad4d being the highest ranked genes for the inflammatory response pathway and Maob, Bckdha, Aldh6a1, Echs1 and Cox8a for the oxidative phosphorylation pathway...
  64. Bach A, Lan N, Johnson D, Abell C, Bembenek M, Kwan S, et al. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988;85:4934-8 pubmed
    ..Based on differences in primary amino acid sequences and RNA gel blot analysis of mRNAs, the A and B forms of monoamine oxidase appear to be derived from separate genes. ..
  65. Rodriguez M, Saura J, Billett E, Finch C, Mahy N. Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system. Cell Tissue Res. 2001;304:215-20 pubmed
    ..They show that both enzymes have a widespread distribution in the human body with a matching pattern in many, but not all tissues, and with strong differences from the pattern of distribution in rodents. ..
  66. Wong W, Ou X, Chen K, Shih J. Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1. J Biol Chem. 2002;277:22222-30 pubmed
    ..In this study, we have shown that phorbol 12-myristate 13-acetate (PMA) increases human MAO B, but not MAO A, gene expression...
  67. Gasso P, Mas S, Bernardo M, Alvarez S, Parellada E, Lafuente A. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. Pharmacogenomics J. 2009;9:404-10 pubmed publisher
    ..AP-induced EPS remains a serious public health problem. Our finding of a common SNP (rs167771) in the DRD3 gene provides a strong new candidate gene for risperidone-induced EPS...
  68. Binda C, Hubalek F, Li M, Herzig Y, Sterling J, Edmondson D, et al. Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J Med Chem. 2004;47:1767-74 pubmed
    Monoamine oxidase B (MAO B) is an outer mitochondrial membrane enzyme that catalyzes the oxidation of arylalkylamine neurotransmitters...
  69. Binda C, Hubalek F, Li M, Herzig Y, Sterling J, Edmondson D, et al. Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem. 2005;48:8148-54 pubmed
    ..Rasagiline is an irreversible, MAO B-selective inhibitor that has been approved as a novel anti-Parkinson's drug...
  70. Pasupuleti S, Sule N, Cohn W, Mackenzie D, Jayaraman A, Manson M. Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid. J Bacteriol. 2014;196:3992-4000 pubmed publisher
    ..Growth with NE induces transcription of genes encoding the tyramine oxidase, TynA, and the aromatic aldehyde dehydrogenase, FeaB, whose respective activities can, in principle, convert ..
  71. Zaib S, Farooq Rizvi S, Aslam S, Ahmad M, Al Rashida M, Iqbal J. Monoamine Oxidase Inhibition and Molecular Modeling Studies of Piperidyl-thienyl and 2-Pyrazoline Derivatives of Chalcones. Med Chem. 2015;11:497-505 pubmed
    ..Whereas among the 2-pyrazoline derivatives of chal-cones, many compounds revealed MAOB inhibition and hence may be applied in the control of senile dementia...
  72. Hao H, Shao M, An J, Chen C, Feng X, Xie S, et al. Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population. Parkinsonism Relat Disord. 2014;20:1041-5 pubmed publisher
    ..Our findings suggest that polymorphisms in COMT and MAO-B may increase the risk of wearing-off and dyskinesias. COMT (GG) genotype may be the risk factor of wearing-off. While MAO-B (AG) genotype may be the risk factor of dyskinesias. ..
  73. Ghozlan A, Munnich A. [MAOB: a modifier gene in phenylketonuria?]. Med Sci (Paris). 2004;20:929-32 pubmed
    ..We suggest here that monoamine oxidase type B, MAOB, an enzyme degrading phenylethylamine, a very toxic metabolite of phenylalanine, could act as a ..
  74. Costa Mallen P, Costa L, Checkoway H. Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men. Neurosci Lett. 2005;385:158-62 pubmed
    ..These results demonstrate that particular combinations of genotypes for MAO-B and DRD2 genes are associated with significantly higher risk for smoking behavior in men, but not in women. ..
  75. Pivac N, Knezevic J, Kozaric Kovacic D, Dezeljin M, Mustapic M, Rak D, et al. Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder. J Affect Disord. 2007;103:131-8 pubmed
    ..The results suggest that platelet MAO-B activity, controlled for smoking status, might be used as a peripheral marker of the psychotic symptoms in PTSD. ..
  76. Pugliese M, Rodriguez M, Gimeno Bayon J, Pujadas L, Billett E, Wells C, et al. Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone. J Neurosci Res. 2010;88:2588-97 pubmed publisher
    ..In the early AD stages, the discrete MAO-B reduction, different from the severe GFAP decrease, would reflect the capacity of this population of MAO-B-positive progenitor cells to adapt to the neurodegenerative process. ..
  77. Torkaman Boutorabi A, Shahidi G, Choopani S, Rezvani M, Pourkosary K, Golkar M, et al. The catechol-O-methyltransferase and monoamine oxidase B polymorphisms and levodopa therapy in the Iranian patients with sporadic Parkinson's disease. Acta Neurobiol Exp (Wars). 2012;72:272-82 pubmed
    ..Recent studies suggest that catechol-O-methyltransferase (COMT), G1947A and monoamine oxidase B (MAOB), A644G polymorphisms might influence the risk and treatment of PD...
  78. Harro J, Fischer K, Vansteelandt S, Harro M. Both low and high activities of platelet monoamine oxidase increase the probability of becoming a smoker. Eur Neuropsychopharmacol. 2004;14:65-9 pubmed
    ..Furthermore, the possible association between above-average platelet MAO activity and behavioural phenotypes should be reexamined. ..
  79. Kiive E, Merenäkk L, Harro M, Harro J. Changes in platelet monoamine oxidase activity, cholesterol levels and hyperactive behaviour in adolescents over a period of three years. Neurosci Lett. 2005;384:310-5 pubmed
    ..This longitudinal analysis provides preliminary evidence that changes in platelet MAO activity and cholesterol, which may reflect changes in central serotonergic activity are associated with attention deficit in adolescents. ..
  80. Torkaman Boutorabi A, Ali Shahidi G, Choopani S, Reza Zarrindast M. Association of monoamine oxidase B and catechol-O-methyltransferase polymorphisms with sporadic Parkinson's disease in an Iranian population. Folia Neuropathol. 2012;50:382-9 pubmed
    ..We performed a case-control study of the association between PD susceptibility and a genetic polymorphism of MAOB and COMT, both separately and in combination, in Iranians...
  81. Purves Tyson T, Owens S, Rothmond D, Halliday G, Double K, Stevens J, et al. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Transl Psychiatry. 2017;7:e1003 pubmed publisher
    ..Midbrain monoamine oxidase A (MAOA) mRNA was increased, whereas MAOB and catechol-O-methyl transferase mRNAs were unchanged in schizophrenia...
  82. Goldin L, Gershon E, Lake C, Murphy D, McGinniss M, Sparkes R. Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity. Am J Hum Genet. 1982;34:250-62 pubmed
    ..A lod score of 0.61 at 0% recombination for a similar analysis in a single large pedigree was reported by Elston et al., making the combined lod score for the two studies equal to 2.32 at 0% recombination. ..
  83. Desautels A, Turecki G, Montplaisir J, Brisebois K, Sequeira A, Adam B, et al. Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. Neurology. 2002;59:215-9 pubmed
    ..To investigate a possible role for the MAOA and MAOB genes in RLS using a population-based association study...
  84. De Colibus L, Li M, Binda C, Lustig A, Edmondson D, Mattevi A. Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A. 2005;102:12684-9 pubmed
    ..Although the chain-fold of hMAO A is similar to that of rat MAO A and human MAO B (hMAO B), hMAO A is unique in that it crystallizes as a monomer and exhibits the solution hydrodynamic behavior of ..
  85. Shih J, Wu J, Chen K. Transcriptional regulation and multiple functions of MAO genes. J Neural Transm (Vienna). 2011;118:979-86 pubmed publisher
    Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide...
  86. Wei Y, Li C, Li S, Liu Y, Hu L. Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese. Behav Brain Funct. 2011;7:42 pubmed publisher
    ..Polymorphisms of isoforms MAOA and MAOB have been implicated in the etiology of mental disorders such as schizophrenia...
  87. Svob Strac D, Kovacic Petrovic Z, Nikolac Perkovic M, Umolac D, Nedic Erjavec G, Pivac N. Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder. Stress. 2016;19:362-73 pubmed publisher the Positive and Negative Syndrome Scale (PANSS)] and platelet MAO-B activity and/or genetic variants of MAOB rs1799836 and MAOA-uVNTR polymorphisms in 249 Croatian male veterans with PTSD...
  88. Kulikova E, Kulikov V, Sinyakova N, Kulikov A, Popova N. The effect of long-term hindlimb unloading on the expression of risk neurogenes encoding elements of serotonin-, dopaminergic systems and apoptosis; comparison with the effect of actual spaceflight on mouse brain. Neurosci Lett. 2017;640:88-92 pubmed publisher
    ..Gdnf, Cdnf), apoptotic factors (Bcl-xl, Bax), serotonin- and dopaminergic systems (5-HT2A, Maoa, Maob, Th, D1r, Comt), and compared the results with the data obtained on mice that spent one month in spaceflight on ..
  89. Mancini F, Di Fonzo A, Lazzeri G, Borellini L, Silani V, Lacerenza M, et al. Real life evaluation of safinamide effectiveness in Parkinson's disease. Neurol Sci. 2018;39:733-739 pubmed publisher
    ..LD), dopamine-agonists (DA), catechol-O-methyl transferase inhibitor (COMT-I), monoamine oxidase B inhibitor (MAOB-I), and their LD equivalent dose (LEDD)...
  90. Wu H, Chen K, Shih J. Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol Pharmacol. 1993;43:888-93 pubmed