MAOA

Summary

Gene Symbol: MAOA
Description: monoamine oxidase A
Alias: MAO-A, amine oxidase [flavin-containing] A, monoamine oxidase type A
Species: human

Top Publications

  1. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
  2. doi Maltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescents
    C Aslund
    Centre for Clinical Research, Central Hospital, Uppsala University, Vasteras, Sweden
    Behav Genet 41:262-72. 2011
  3. pmc MAOA methylation is associated with nicotine and alcohol dependence in women
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:565-70. 2008
  4. ncbi The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
  5. ncbi Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 17:867-72. 2007
  6. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
  7. doi Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study
    Gil Zalsman
    Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel
    World J Biol Psychiatry 12:33-41. 2011
  8. ncbi Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
    J W Buckholtz
    Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Mol Psychiatry 13:313-24. 2008
  9. doi Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation
    Antonio Cerasa
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    Brain Res 1201:114-21. 2008
  10. ncbi Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies
    Beatriz Camarena
    Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente México DF, Mexico DF, Mexico
    Neuropsychobiology 49:126-9. 2004

Detail Information

Publications227 found, 100 shown here

  1. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species...
  2. doi Maltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescents
    C Aslund
    Centre for Clinical Research, Central Hospital, Uppsala University, Vasteras, Sweden
    Behav Genet 41:262-72. 2011
    The present study investigated a possible interaction between a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and childhood maltreatment in the prediction of adolescent male and female delinquency...
  3. pmc MAOA methylation is associated with nicotine and alcohol dependence in women
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:565-70. 2008
    ..One prominent locus at which epigenetic phenomena are thought to be in play is the monoamine oxidase A (MAOA) locus...
  4. ncbi The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
    ..Parenting characteristics have been shown to influence development of antisociality, moderated by variation at the MAOA gene, which has also been associated with the risk for substance use disorders...
  5. ncbi Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 17:867-72. 2007
    The genes of catalytic enzymes of dopamine, including monoamine oxidase (MAOA and MAOB) and catechol-O-methyltransferase (COMT), have been major candidates for genes that affect smoking behavior...
  6. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment...
  7. doi Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study
    Gil Zalsman
    Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel
    World J Biol Psychiatry 12:33-41. 2011
    ..Suicidal behaviour runs in families. This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents.
  8. ncbi Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
    J W Buckholtz
    Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Mol Psychiatry 13:313-24. 2008
    ..To identify these circuits, we used a combined genetic and imaging approach focused on Monoamine Oxidase A (MAOA), encoding a key enzyme for monoamine metabolism previously associated with temperament and antisocial behavior...
  9. doi Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation
    Antonio Cerasa
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    Brain Res 1201:114-21. 2008
    ..The X-linked Mono-Amine Oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin (5-HT) catabolism, presents a well-characterized ..
  10. ncbi Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies
    Beatriz Camarena
    Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente México DF, Mexico DF, Mexico
    Neuropsychobiology 49:126-9. 2004
    ..0, p = 0.005). Our findings may provide evidence of a candidate gene involved in obese subjects with a BMI >/=35 kg/m(2)...
  11. doi MAOA and the neurogenetic architecture of human aggression
    Joshua W Buckholtz
    Vanderbilt Brain Institute and Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Trends Neurosci 31:120-9. 2008
    ..are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent...
  12. doi A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder
    JieXu Zhang
    Institute of Basic Medical Sciences, Tsinghua University, Beijing, China
    Biol Psychiatry 68:795-800. 2010
    ..To better understand the mechanism by which the monoamine oxidase A (MAOA) gene may play a role in developing MDD, the present work examined the cis-phase interaction between genetic ..
  13. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    ..among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality...
  14. doi MAOA gene polymorphisms and response to mirtazapine in major depression
    Dong Sheng Tzeng
    Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan
    Hum Psychopharmacol 24:293-300. 2009
    Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD).
  15. pmc Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation
    Rose McDermott
    Department of Political Science, Brown University, 36 Prospect Street, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 106:2118-23. 2009
    Monoamine oxidase A gene (MAOA) has earned the nickname "warrior gene" because it has been linked to aggression in observational and survey-based studies...
  16. ncbi The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S 721 89, Vasteras, Sweden
    Drug Alcohol Depend 93:51-62. 2008
    ....
  17. ncbi MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis
    J Kim-Cohen
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Mol Psychiatry 11:903-13. 2006
    ..research on adults has shown that a functional polymorphism in the promoter region of the monoamine oxidase A (MAOA) gene moderates the impact of childhood maltreatment on risk for developing antisocial behavior...
  18. doi Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts
    Chia Chang Chien
    Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    World J Biol Psychiatry 11:409-16. 2010
    To explore the involvement of variable number tandem repeat (VNTR) polymorphisms in the monoamine oxidase A (MAOA) promoter and exon 3 of the dopamine D4 receptor (DRD4) gene in heroin addiction modulate the vulnerability of individuals ..
  19. pmc Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Monit 14:CR57-61. 2008
    The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. A polymorphism in the promoter region (MAOA-uVNTR) affects transcriptional efficiency...
  20. ncbi Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain
    J Saura
    F Hoffmann La Roche Ltd, Pharma Division, Basel, Switzerland
    J Neurosci 12:1977-99. 1992
    ..The physiological roles of the enzymes are discussed in the light of these findings, some of which were unexpected.(ABSTRACT TRUNCATED AT 400 WORDS)..
  21. ncbi MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males
    Lisheng Du
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 15:2097-101. 2004
    ..These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients...
  22. pmc Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
    Yi Mei J Lin
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
    Behav Brain Funct 4:21. 2008
    ..abstract:..
  23. ncbi Meta-study on association between the monoamine oxidase A gene (MAOA) and schizophrenia
    Dawei Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Am J Med Genet B Neuropsychiatr Genet 147:174-8. 2008
    The human monoamine oxidase A gene (MAOA) has attracted considerable attention as a candidate gene for schizophrenia based both on its chromosomal position and its enzyme function as a key factor in neurotransmitter catabolism pathways...
  24. doi Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population
    Hai Tang Qiu
    Department of Mental Health, First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Brain Res 1287:67-73. 2009
    ..Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder...
  25. pmc MAOA-uVNTR and early physical discipline interact to influence delinquent behavior
    Alexis C Edwards
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    J Child Psychol Psychiatry 51:679-87. 2010
    A functional polymorphism in the promoter region of the monoamine oxidizing gene monoamine oxidase A (MAOA) has been associated with behavioral sensitivity to adverse environmental conditions in multiple studies (e.g., Caspi et al...
  26. ncbi High activity-related allele of MAO-A gene associated with depressed suicide in males
    Lisheng Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 13:1195-8. 2002
    ..The results thus provide further evidence that genetic factors can modulate risk for depression, suicide or both by influencing monoaminergic activity in sexually dimorphic manner...
  27. ncbi [Genetic basis of time perception in athletes]
    G V Portnova
    Zh Vyssh Nerv Deiat Im I P Pavlova 57:450-60. 2007
    ..5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow...
  28. doi Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population
    San Yuan Huang
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan, ROC
    World J Biol Psychiatry 10:544-51. 2009
    It has been proposed that an MAOA abnormality may be an important factor in the development of major depressive disorder (MDD)...
  29. ncbi Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
    ..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD...
  30. ncbi Obesity is associated with genetic variants that alter dopamine availability
    A C Need
    Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT
    Ann Hum Genet 70:293-303. 2006
    ..Dopamine availability is controlled largely by three enzymes: COMT, MAOA and MAOB, and by the dopamine transporter SLC6A3, and each gene has a well-characterized functional variant...
  31. pmc Monoamine oxidase A gene (MAOA) associated with attitude towards longshot risks
    Songfa Zhong
    Center for Experimental Business Research and Department of Economics, Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region, Hong Kong
    PLoS ONE 4:e8516. 2009
    ..association with a widely studied, promoter-region repeat functional polymorphism in monoamine oxidase A gene (MAOA)...
  32. ncbi Monoamine oxidase a gene is associated with borderline personality disorder
    Xingqun Ni
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatr Genet 17:153-7. 2007
    ..As for its role in aggression, impulsivity, suicide and mood liability, monoamine oxidase A can be considered a functional candidate in borderline personality disorder...
  33. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
    ..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)...
  34. ncbi Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders
    Blanca Gutierrez
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Psychiatr Genet 14:203-8. 2004
    Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and ..
  35. ncbi Monoamine oxidase polymorphisms and smoking behaviour in Japanese
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya Aichi 464 8681, Japan
    Pharmacogenetics 13:73-9. 2003
    ..These findings among male smokers support the view that MAO affects a smokers' requirement for nicotine and may explain why some people are predisposed to tobacco addiction and why some individuals find it difficult to stop smoking...
  36. ncbi A regulatory monoamine oxidase a promoter polymorphism and personality traits
    Håkan Garpenstrand
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 46:190-3. 2002
    b>Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders...
  37. ncbi Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients
    Susan E Young
    Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
    Am J Psychiatry 163:1019-25. 2006
    ....
  38. pmc Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence
    San Yuan Huang
    Department of Psychiatry, Tri Service General Hospital, Taiwan, ROC
    J Psychiatry Neurosci 32:185-92. 2007
    ..Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.
  39. doi Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex
    Luca Passamonti
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, 87050, Italy
    Neuroimage 40:1264-73. 2008
    ..Although with conflicting findings, the monoamine oxidase-A (MAOA) and the serotonin transporter (5HTT) gene polymorphisms have been associated with an increased risk to develop ..
  40. pmc The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity
    Guang Guo
    Department of Sociology, Carolina Center for Genome Sciences, Carolina Population Center, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 3210, USA
    Eur J Hum Genet 16:626-34. 2008
    ..in the United States, the present study demonstrates a link between the rare 2 repeat of the 30-bp VNTR in the MAOA gene and much higher levels of self-reported serious and violent delinquency...
  41. ncbi The influence of four serotonin-related genes on decision-making in suicide attempters
    Fabrice Jollant
    Universite Montpellier 1, Montpellier, France
    Am J Med Genet B Neuropsychiatr Genet 144:615-24. 2007
    ..Patients were genotyped for four serotonergic polymorphisms: 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997...
  42. ncbi MAOA and persistent, pervasive childhood aggression
    J H Beitchman
    Mol Psychiatry 9:546-7. 2004
  43. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia...
  44. ncbi An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1498-505. 2004
    Monoamine oxidase A (MAOA) activity is altered in mood disorders and lower activity associated with aggressive behavior...
  45. ncbi Association of autism severity with a monoamine oxidase A functional polymorphism
    I L Cohen
    Departments of Psychology, Cytogenetics and Human Genetics, Staten Island, New York 10314, USA
    Clin Genet 64:190-7. 2003
    A functional polymorphism (the upstream variable-number tandem repeat region, or uVNTR) in the monoamine oxidase A (MAOA) promoter region has been reported to be associated with behavioral abnormalities as well as increased serotonergic ..
  46. doi The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia
    A Reif
    Department of Psychiatry and Psychotherapy, Section of Clinical and Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Neurol 15:637-9. 2008
    ..FTD patients and 151 controls matched to age and genotyped them for a functional promoter polymorphism, termed MAOA-uVNTR. However, no significant differences were observed between patients and controls...
  47. ncbi Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease
    E R Levy
    Genetics Laboratory, Department of Biochemistry, Oxford, United Kingdom
    Genomics 5:368-70. 1989
    ..23-11.4. As restriction fragments detected by this probe are deleted in some patients with Norrie disease, this assignment provides confirmation of the localization of the disease...
  48. doi Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036 8562 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1932-5. 2008
    ..between a polymorphism involving a variable number of tandem repeats in the promoter of the monoamine oxidase A (MAOA-VNTR) gene and personality traits, as assessed by the Temperament and Character Inventory (TCI)...
  49. pmc Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo
    Brian J Mickey
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 28:11354-9. 2008
    ..These results demonstrate a sex-specific interaction between two key molecules of the human serotonergic system, and suggest a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes...
  50. ncbi Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  51. doi Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder...
  52. ncbi Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism
    L Ozelius
    Molecular Neurogenetics, E K Shriver Center, Waltham, Massachusetts 02254
    Genomics 3:53-8. 1988
    An essentially full-length cDNA clone for the human enzyme monoamine oxidase type A (MAO-A) has been used to determine the chromosomal location of a gene encoding it...
  53. doi High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees
    Esther J M van der Vegt
    Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    Psychiatr Genet 19:209-11. 2009
    ..Our results suggest that in severely maltreated children, high MAO-A activity may not protect against the effects of maltreatment but may convey an increased risk for externalizing behaviour...
  54. pmc Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    J Neural Transm 116:1323-34. 2009
    Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect...
  55. doi Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females
    E C Prom-Wormley
    Department of Integrative Life Sciences, Virginia Commonwealth University 23298 0126, USA
    Psychol Med 39:579-90. 2009
    ..have reported a genotype-environment interaction (GxE) in which low-activity alleles at the monoamine oxidase A (MAOA) locus conferred greater sensitivity to the effects of childhood adversity on risk for conduct disorder (CD)...
  56. doi MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption
    Kent W Nilsson
    Centre for Clinical Research, Central Hospital, Vasteras, S 721 89 Västerås, Sweden
    Addict Biol 16:347-55. 2011
    The aim of the present study was to investigate MAOA gene-environment (G*E) interactions in relation to adolescent alcohol consumption...
  57. ncbi No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides
    Hisae Ono
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Kobe, Japan
    Am J Med Genet 114:340-2. 2002
    Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide...
  58. pmc X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism
    H G Brunner
    Department of Human Genetics, University Hospital, Nijmegen, The Netherlands
    Am J Hum Genet 52:1032-9. 1993
    ..A maximal multipoint lod score of 3.69 was obtained at the monoamine oxidase type A (MAOA) locus in Xp11.23-11.4...
  59. ncbi The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
    Shai Rosenberg
    Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 120:447-59. 2006
    Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues...
  60. ncbi Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
    David Huizinga
    Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
    Biol Psychiatry 60:677-83. 2006
    A functional promoter polymorphism in monoamine oxidase A (MAOA) has been implicated as a moderating factor in the relationship between childhood maltreatment and later adolescent and adult antisocial behavior...
  61. ncbi Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males
    Ying Jin
    Peking University Stem Cell Research Center, Beijing Anding Hospital Affiliated Capital University of Medical Sciences, China
    Int J Neuropsychopharmacol 9:557-64. 2006
    ..We investigated the association between MAOA polymorphisms (a VNTR polymorphism and an EcoRV polymorphism) and smoking status...
  62. ncbi Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors
    Rickard L Sjoberg
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Vasteras, Sweden
    Am J Med Genet B Neuropsychiatr Genet 144:159-64. 2007
    ..findings among boys show that interactions between a polymorphism in the monoamine oxidase A gene promoter region (MAOA-LPR) and psychosocial factors predict criminal activity...
  63. ncbi Monoallelic expression of MAOA in skin fibroblasts
    Niklas Nordquist
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Biochem Biophys Res Commun 348:763-7. 2006
    ..Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences...
  64. ncbi Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity
    Luca Passamonti
    Neurology Unit, Department of Neurosciences, University Politecnica delle Marche, Ancona, Italy
    Biol Psychiatry 59:334-40. 2006
    ..High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers...
  65. pmc Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway
    Xiao Ming Ou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 103:10923-8. 2006
    Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death...
  66. ncbi Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?
    Agnes L Nishimura
    Human Genome Research Center, Biology Department, Institute of Biosciences, São Paulo University IBUSP, Sao Paulo, Brazil
    J Mol Neurosci 27:213-7. 2005
    ..Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls...
  67. ncbi Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 135:59-64. 2005
    ..Animal and human studies suggest that variation in monoamine oxidase A (MAOA) genotype may moderate the effects of maltreatment...
  68. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
    Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3...
  69. ncbi Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
    H G Brunner
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Science 262:578-80. 1993
    ..This syndrome was associated with a complete and selective deficiency of enzymatic activity of monoamine oxidase A (MAOA)...
  70. ncbi Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taiwan, ROC
    Neuropsychopharmacology 30:1719-23. 2005
    Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of biogenic amines, may be implicated in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants...
  71. ncbi Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S 721 89 Västerås, Sweden
    Biol Psychiatry 59:121-7. 2006
    ..The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity...
  72. doi Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis
    Laura Filonzi
    Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy
    Neurogenetics 10:65-72. 2009
    ..synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated...
  73. pmc Mapping the genetic variation of executive attention onto brain activity
    Jin Fan
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7406-11. 2003
    ..We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time ..
  74. pmc Genes implicated in serotonergic and dopaminergic functioning predict BMI categories
    Bernard F Fuemmeler
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Obesity (Silver Spring) 16:348-55. 2008
    ..with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as ..
  75. ncbi Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (T
    I Manor
    Geha Mental Health Center, Petak Tikvah, Israel
    Mol Psychiatry 7:626-32. 2002
    Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin...
  76. doi Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism
    Camilla Gokturk
    Department of Neuroscience, Pharmacology, Uppsala University, Uppsala, Sweden
    Arch Womens Ment Health 11:347-55. 2008
    ..in the promoter region of the serotonin transporter and monoamine oxidase-A, respectively, (5-HTT-LPR and MAOA-VNTR), was performed in a group of women with severe alcohol addiction...
  77. ncbi The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Vasteras, Sweden
    Addiction 102:389-98. 2007
    ..To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents...
  78. doi A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, Australia
    Neuropsychopharmacology 34:1797-809. 2009
    Association studies suggest that the low activity variant of the monoamine oxidase A (MAOA)-uVNTR polymorphism confers risk for emotional disturbances associated with antisocial traits, particularly in males...
  79. ncbi Investigation of serotonin-related genes in antidepressant response
    E J Peters
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Mol Psychiatry 9:879-89. 2004
    ..genotyped patients at 110 SNPs and four repeat polymorphisms located in seven candidate genes (HTR1A, HTR2A, HTR2C, MAOA, SLC6A4, TPH1, and TPH2)...
  80. ncbi Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression
    A Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 117:1-6. 2003
    ..to detect a possible association of a T941G single nucleotide polymorphism (SNP) in the monoamine oxidase A (MAOA) gene with generalized anxiety disorder (GAD), panic disorder (PD), or major depression (MD)...
  81. ncbi Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
    Deborah C Lawson
    Department of Psychologycal Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:84-9. 2003
    ..Monoamine Oxidase A (MAOA) is involved in the degradation of all three of these neurotransmitters and therefore has been suggested as a ..
  82. ncbi Association of monoamine oxidase A gene polymorphism with Alzheimer's disease and Lewy body variant
    Masanori Takehashi
    Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Neurosci Lett 327:79-82. 2002
    The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined...
  83. pmc Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior
    L S Wakschlag
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60608, USA
    Mol Psychiatry 15:928-37. 2010
    ..We tested whether a functional polymorphism in the gene encoding the enzyme monoamine oxidase A (MAOA) interacts with exposure to predict pathways to adolescent antisocial behavior...
  84. doi Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome
    Francesco Nonnis Marzano
    Department of Evolutionary and Functional Biology, University of Parma, 43100 Parma, Italy
    Genomics 91:485-91. 2008
    ..frequencies of TPH2, 5-HTTLPR, the 5-HTT (SLC6A4) intron 2 variable-number tandem repeat (VNTR) region, and the MAOA VNTR region were determined in brain-stem samples of 20 "genuine" SIDS cases and compared with results obtained ..
  85. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
    ....
  86. ncbi MAOA and the "cycle of violence:" childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior
    Cathy Spatz Widom
    Department of Psychiatry, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA
    Biol Psychiatry 60:684-9. 2006
    Two recent studies with white males have shown that genotypes associated with high levels of monamine oxidase A (MAOA) protect against the impact of childhood maltreatment and adversity on the development of antisocial behavior and ..
  87. ncbi A functional polymorphism in the promoter region of the monoamine oxidase A gene is associated with the cigarette smoking quantity in alcohol-dependent heavy smokers
    Gerhard A Wiesbeck
    Division of Substance Use Disorders, Psychiatric University Hospital Basel, Basel, Switzerland gerhard wiesbeck upkbs ch
    Neuropsychobiology 53:181-5. 2006
    ..Taken together, in alcohol-dependent heavily smoking men there is evidence for a MAO-A gene-associated effect on the quantity that is smoked as reflected by the daily number of cigarettes consumed...
  88. ncbi Mutational analysis of the human MAOA gene
    E A Tivol
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Med Genet 67:92-7. 1996
    ..Wide variations in activity of these isozymes have been reported in control humans. The MAOA and MAOB genes are located next to each other in the p11.3-11.4 region of the human X chromosome...
  89. ncbi Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs
    O Cases
    Department of Physiology, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland
    J Neurosci 18:6914-27. 1998
    Genetic loss or pharmacological inhibition of monoamine oxidase A (MAOA) in mice leads to a large increase in whole-brain levels of serotonin (5-HT)...
  90. pmc Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 5:325-42. 2010
    Monoamine oxidase A (MAO A) is an enzyme that catalyzes the oxidation of neurotransmitter amines. A functional polymorphism in the human MAOA gene (high- and low-MAOA) has been associated with distinct behavioral phenotypes...
  91. ncbi Gene-gene interaction between the monoamine oxidase A gene and solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype)
    Ruth E Urwin
    Department of Psychological Medicine, The Children s Hospital at Westmead, Westmead, NSW, Australia
    Eur J Hum Genet 11:945-50. 2003
    ..further examine the noradrenergic system in AN-R we performed an association study with a functional polymorphism (MAOA-uVNTR) in the promoter of the monoamine oxidase A (MAOA) gene...
  92. ncbi An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder
    K A Nolan
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Psychiatr Genet 10:109-15. 2000
    ..region of the serotonin transporter (5-HTT), in intron 7 of the tryptophan hydroxylase (TPH) gene and in the MAOA gene were previously reported to be associated with mood and anxiety disorders, impulsivity and aggression...
  93. ncbi Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates
    J R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Genes Brain Behav 5:40-5. 2006
    By conferring allele-specific transcriptional activity on the monoamine oxidase A (MAOA) gene in humans, length variation of a repetitive sequence [(variable number of tandem repeat (VNTR)] in the MAOA promoter influences a constellation ..
  94. ncbi The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats
    Thomas E Wooters
    Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Behav Pharmacol 18:601-8. 2007
    ..This study examined the effects of three MAOIs (phenelzine, clorgyline and pargyline) with varying selectivity for MAOA and MAOB in the nicotine drug discrimination procedure in rats...
  95. ncbi Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter
    Lea Stankovski
    Institut National de la Sante et de la Recherche Medicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hopital de la Pitie Salpetriere, 75651 Paris, France
    J Neurosci 27:1315-24. 2007
    ..However, when monoamine oxidase type A was invalidated in the VMAT2 KO background (VMAT2-MAOA DKO mice), increases in 5-HT levels coincided with ..
  96. ncbi Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives
    Tania Vitalis
    Department of Anatomy and Developmental Biology, University College London, WC1E6BT London, United Kingdom
    J Comp Neurol 464:392-403. 2003
    ..In contrast, MAOA expression was restricted to the sympathetic ganglia and to the meningeal and capillary blood vessels...
  97. ncbi Turner syndrome and Xp deletions: clinical and molecular studies in 47 patients
    T Ogata
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 86:5498-508. 2001
    ..muscular dystrophy and were often present in groups 2 and 3 missing the region distal to monoamine oxidase A (MAOA)...
  98. doi Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorph
    David K Miller
    LifeStream Solutions, Inc, Prescott, AZ, USA
    Postgrad Med 122:188-213. 2010
    ..exon 3 VNTR (DRD4), DRD2 TaqIA (rs1800497), COMT val158 met SNP (rs4680), monoamine oxidase A upstream VNTR (MAOA-uVNTR), and serotonin transporter-linked polymorphic region (5HTTLPR, locus symbol SLC6A4)...
  99. doi Allele-specific expression of the MAOA gene and X chromosome inactivation in in vitro produced bovine embryos
    A R Ferreira
    Embrapa Genetic Resources and Biotechnology, Laboratory of Animal Reproduction, Brasilia, DF, Brazil
    Mol Reprod Dev 77:615-21. 2010
    ..by characterizing the allele-specific expression pattern of the X chromosome-linked gene, monoamine oxidase A (MAOA)...
  100. ncbi The monoamine regulon including syntheses of arylsulfatase and monoamine oxidase in bacteria
    Y Murooka
    Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan
    Biosci Biotechnol Biochem 60:935-41. 1996
    ..or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA. These monoamine compounds also derepress the synthesis of atsA-specified arylsulfatase that is repressed by sulfur ..

Research Grants75

  1. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..These genes include MAOA, XIST. ELF4, FACL4; PLP1, PPEF1, SYP, SYNl, BGN, and TBLl...
  2. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..OCD; b) linkage using affected-relative pairs to 4 candidate gene regions (SLC6A4-serotonin transporter, COMT, MAOA, DRD4) using 3 SNP biallelic markers and 4 flanking microsatellite markers; c) complex segregation analysis to ..
  3. The Genetics of Negative Conflict Behavior
    Mark Miller; Fiscal Year: 2007
    ..primary hypotheses: First, genetic association analyses are expected to show that dopamine and monoamine oxidase (MAOA) polymorphisms exert direct effects on NCB and indirect effects on this outcome mediated by externalizing ..
  4. THE NEUROBIOLOGY OF SUICIDAL BEHAVIOR
    JOSEPH MANN; Fiscal Year: 2007
    ..Effects of susceptibility gene expression on binding to 5-HTT, 5-HTiA and MAOA will be determined by PET and related to depression and suicidal behavior...
  5. Age-27 Follow-up of Early Preventive Intervention
    David Olds; Fiscal Year: 2007
    ..with genetic vulnerabilities for behavioral dysregulation (functional polymorphisms in the gene that encodes MAOA, the dopamine transporter gene, and the (7 nicotine receptor gene) in combination with environmental risks (..
  6. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2004
    ..Among these loci, the genes encoding dopamine receptors and monoamine oxidase A (MAOA) attract special attention because of their demonstrated or hypothesized involvement in the risk for substance ..
  7. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ..from five carefully selected regions - the serotonin transporter gene (SLC6A4), the monoamine oxidase A gene (MAOA), the catechol-O-methyltransferase gene (COMT), the type 4 dopamine receptor gene (DRD4), and a series of tag SNPs ..
  8. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2010
    ..This will concentrate initially on monoamine oxidase A (MAOA)...
  9. Modeling the Neurogenetics of Serotonin Regulation
    ERIC VALLENDER; Fiscal Year: 2007
    ..application seeks to explore the neurogenetic diversity of serotonin transporter (SERT) and Monoamine Oxidase A (MAOA) genes in rhesus monkeys...
  10. Gene x Environment Factors in Smoking Cessation
    Andrew Hyland; Fiscal Year: 2007
    ..factors including the following genes: DRD2 and DRD4 (dopamine receptor); SLC6A3 (dopamine transporter); DBH, COMT, MAOA (dopamine metabolism); 5-HTT (serotonin transporter), and CYP2A6, CYP2B6, and CYP2D6 (nicotine metabolism)...
  11. The Genetics of Negative Conflict Behavior
    Mark W Miller; Fiscal Year: 2010
    ..primary hypotheses: First, genetic association analyses are expected to show that dopamine and monoamine oxidase (MAOA) polymorphisms exert direct effects on NCB and indirect effects on this outcome mediated by externalizing ..
  12. Machine Learning for Analysis of functional MRI of Underlying Inhibitory Control
    Dimitrios Samaras; Fiscal Year: 2010
    ..spatial brain pattern will indicate a diagnosis of drug addiction and a membership in one or another level ol MAOA genotype...
  13. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ..These analyses will consider polymorphisms in SLC6A3, DRD4, DRD2, SLC6A4, & MAOA as well as measures of religiosity and other social and demographic context including family structure, parental ..
  14. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2007
    ..pathways, encoding synthetic and catabolic enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  15. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2010
    ..pathways, encoding synthetic and catabolic enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  16. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2007
    ..pathways, encoding synthetic and catabolic enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  17. Dependence of the Development of Attention on Genotype
    John Fossella; Fiscal Year: 2007
    ..of several dopaminergic genes that have been associated with developmental disabilities showed that the DRD4 and MAOA genes showed associations with efficiency of executive attention and that frontal midline regions including the ACC ..
  18. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia Klein; Fiscal Year: 2010
    ..Specifically, monoamine oxidase A (MAO A), an enzyme regulating the neurotransmitters serotonin and norepinephrine, has been reliably implicated in ..
  19. A thyroid receptor co-activator hypothesis for psychosis
    Robert Philibert; Fiscal Year: 2005
    ..The net effect will be to produce an independent investigator capable of functional and translational research. ..
  20. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2007
    ....
  21. Intergenerational Research on Obesity Prevention: From Correlates to Intervention
    Bernard Fuemmeler; Fiscal Year: 2007
    ..This research proposal is aligned with NCI's strategic goals in energy balance (e.g., Transdisciplinary Research on Energetic and Cancer) and the NIH's Obesity Task Force. ..
  22. Elucidating links between ADHD symptoms and tobacco/alcohol use trajectories
    Bernard F Fuemmeler; Fiscal Year: 2010
    ..Such knowledge is necessary for effective preventive intervention planning and implementation. ..
  23. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..