mannose 6 phosphate uncovering enzyme


Gene Symbol: mannose 6 phosphate uncovering enzyme
Description: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Alias: APAA, UCE, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate-uncovering enzyme, phosphodiester alpha-GlcNAcase
Species: human

Top Publications

  1. Lee W, Kang C, Drayna D, Kornfeld S. Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering. J Biol Chem. 2011;286:39786-93 pubmed publisher
    GlcNAc-1-phosphodiester-N-acetylglucosaminidase ("uncovering enzyme" (UCE); EC is a Golgi enzyme that mediates the second step in the synthesis of the mannose 6-phosphate lysosomal targeting signal on acid hydrolases...
  2. Kang C, Riazuddin S, Mundorff J, Krasnewich D, Friedman P, Mullikin J, et al. Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering. N Engl J Med. 2010;362:677-85 pubmed publisher
    ..Susceptibility to nonsyndromic stuttering is associated with variations in genes governing lysosomal metabolism. ..
  3. Chen T, Wu J, Kan Y, Yang C, Wu Y, Wu J. Antioxidant and Hepatoprotective Activities of Crude Polysaccharide Extracts from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by Ultrasonic-Circulating Extraction. Int J Med Mushrooms. 2018;20:581-593 pubmed publisher
    We recently proposed, and successfully applied, a novel and efficient technique-ultrasonic-circulating extraction (UCE) integrating superfine pulverization-to extract and prepare antioxidant crude polysaccharides other natural active ..
  4. Bossert S, Murray E, Almeida E, Brady S, Blaimer B, Danforth B. Combining transcriptomes and ultraconserved elements to illuminate the phylogeny of Apidae. Mol Phylogenet Evol. 2019;130:121-131 pubmed publisher
    ..While targeted exon sequencing across divergent lineages is now a standard method, it is still not clear if UCE data can be readily combined with published transcriptomes...
  5. Kieran T, Gordon E, Forthman M, Hoey Chamberlain R, Kimball R, Faircloth B, et al. Insight from an ultraconserved element bait set designed for hemipteran phylogenetics integrated with genomic resources. Mol Phylogenet Evol. 2019;130:297-303 pubmed publisher
    ..We use a recently designed ultraconserved element (UCE) bait set for Hemiptera, with a focus on the suborder Heteroptera, or the true bugs, to test previously proposed ..
  6. Zheng C, Zou X, Zhao B, Zhang M, Lin H, Luo C, et al. miRNA-185 regulates retained fetal membranes of cattle by targeting STIM1. Theriogenology. 2019;126:166-171 pubmed publisher investigating the regulatory relationship between miRNA-185 and STIM1 in primary uterine caruncel epithelial (UCE) cells...
  7. Arpey N, Sloan M, Hahn A, Polgreen P, Erickson B. Unscheduled Clinical Encounters in the Postoperative Period After Adult and Pediatric Urologic Surgery. Urology. 2019;124:113-119 pubmed publisher
    ..Demographic and perioperative data for each patient and surgery was recorded and risk factors for UCE were determined using uni- and multivariate analyses...
  8. Locke S, Van Dam A, Caffara M, Pinto H, López Hernández D, Blanar C. Validity of the Diplostomoidea and Diplostomida (Digenea, Platyhelminthes) upheld in phylogenomic analysis. Int J Parasitol. 2018;: pubmed publisher
    ..Complete rDNA operons from seven diplostomoid species are provided as a resource for future studies. ..
  9. Darrin Hulsey C, Zheng J, Holzman R, Alfaro M, Olave M, Meyer A. Phylogenomics of a putatively convergent novelty: did hypertrophied lips evolve once or repeatedly in Lake Malawi cichlid fishes?. BMC Evol Biol. 2018;18:179 pubmed publisher
    ..Contrary to mitochondrial DNA phylogenies, bifurcating trees based on our 1024 UCE loci supported close affinities of Lake Malawi lineages with hypertrophied lips...

More Information


  1. Faircloth B, Sorenson L, Santini F, Alfaro M. A Phylogenomic Perspective on the Radiation of Ray-Finned Fishes Based upon Targeted Sequencing of Ultraconserved Elements (UCEs). PLoS ONE. 2013;8:e65923 pubmed publisher
    ..Analysis of the UCE data set recovers a well-supported phylogeny at both shallow and deep time-scales that supports a monophyletic ..
  2. Chen D, Braun E, Forthman M, Kimball R, Zhang Z. A simple strategy for recovering ultraconserved elements, exons, and introns from low coverage shotgun sequencing of museum specimens: Placement of the partridge genus Tropicoperdix within the galliformes. Mol Phylogenet Evol. 2018;129:304-314 pubmed publisher
    ..other (a reduced complexity assembly approach), and allowed us to obtain a large number of ultraconserved element (UCE) loci, relatively conserved exons, more variable introns, as well as mitochondrial genomes...
  3. Cajigas I, Chakraborty A, Swyter K, Luo H, Bastidas M, Nigro M, et al. The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain. Mol Cell. 2018;71:956-972.e9 pubmed publisher
    ..Here we show that Evf2, a cloud-forming Dlx5/6 ultraconserved enhancer (UCE) lncRNA, simultaneously localizes to activated (Umad1, 1...
  4. Ferreira M, Fernandes A, Aleixo A, Antonelli A, Olsson U, Bates J, et al. Evidence for mtDNA capture in the jacamar Galbula leucogastra/chalcothorax species-complex and insights on the evolution of white-sand ecosystems in the Amazon basin. Mol Phylogenet Evol. 2018;129:149-157 pubmed publisher
    ..leucogastra. In contrast, both concatenated and species-tree analyses of UCE data recovered G. chalcothorax as sister to all G. leucogastra lineages...
  5. Hessels L, Koopmans N, Gomes Neto A, Volbeda M, Koeze J, Lansink Hartgring A, et al. Urinary creatinine excretion is related to short-term and long-term mortality in critically ill patients. Intensive Care Med. 2018;44:1699-1708 pubmed publisher
    ..Urinary creatinine excretion (UCE) reflects muscle mass, but has not been studied in critically ill patients...
  6. Han T, Park J, Domingues C, Moretti Ferreira D, Paris E, Sainz E, et al. A study of the role of the FOXP2 and CNTNAP2 genes in persistent developmental stuttering. Neurobiol Dis. 2014;69:23-31 pubmed publisher
  7. Crawford N, Parham J, Sellas A, Faircloth B, Glenn T, Papenfuss T, et al. A phylogenomic analysis of turtles. Mol Phylogenet Evol. 2015;83:250-7 pubmed publisher
    ..Here we provide the first genome-scale analysis of turtle phylogeny. We sequenced 2381 ultraconserved element (UCE) loci representing a total of 1,718,154bp of aligned sequence...
  8. De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton Dutoit S, Ferrandez A, et al. Urea cycle dysregulation in non-alcoholic fatty liver disease. J Hepatol. 2018;69:905-915 pubmed publisher
    ..This results in hyperammonemia, possibly through hypermethylation of UCE genes and impairment of urea synthesis...
  9. Gilbert P, Wu J, Simon M, Sinsheimer J, Alfaro M. Filtering nucleotide sites by phylogenetic signal to noise ratio increases confidence in the Neoaves phylogeny generated from ultraconserved elements. Mol Phylogenet Evol. 2018;126:116-128 pubmed publisher
    ..Using our approach, we investigate whether filtering UCE loci on their phylogenetic signal to noise ratio helps to resolve key nodes in the Neoaves tree of life...
  10. Kretzschmar J, Brendler E, Wagler J, Schmidt A. Kinetics and activation parameters of the reaction of organoarsenic(V) compounds with glutathione. J Hazard Mater. 2014;280:734-40 pubmed publisher
    ..compounds phenylarsonic acid (PAA), 4-hydroxy-3-nitrophenylarsonic acid (HNPAA), p-aminophenylarsonic acid (p-APAA) and o-aminophenylarsonic acid (o-APAA) as well as monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA) is ..
  11. Haas C, Hanson E, Banemann R, Bento A, Berti A, Carracedo Ã, et al. RNA/DNA co-analysis from human skin and contact traces--results of a sixth collaborative EDNAP exercise. Forensic Sci Int Genet. 2015;16:139-147 pubmed publisher
    ..CCL27) and skin2 triplex (LOR, KRT9 and CDSN) in conjunction with a housekeeping gene, HKG, triplex (B2M, UBC and UCE). The laboratories used different chemistries and instrumentation...
  12. Ruano Nieto C, Melo Pérez J, Mogrovejo Freire L, De Paula Morales K, Espinoza Romero C. [Prevalence of metabolic syndrome and associated risk factors in ecuadorian university students]. Nutr Hosp. 2015;31:1574-81 pubmed publisher
    ..of metabolic syndrome and its risk factors in a sample of students from the "Universidad Central del Ecuador" (UCE) in Quito. Students form first, second and third semester of Medicine College in UCE were included in the study...
  13. Wood H, González V, Lloyd M, Coddington J, Scharff N. Next-generation museum genomics: Phylogenetic relationships among palpimanoid spiders using sequence capture techniques (Araneae: Palpimanoidea). Mol Phylogenet Evol. 2018;127:907-918 pubmed publisher
    ..uses museum specimens and recent target capture sequencing techniques to sequence both Ultra-Conserved Elements (UCE) and exonic regions for lineages that span the modern spiders, Araneomorphae, with a focus on Palpimanoidea...
  14. Boonen M, Vogel P, Platt K, Dahms N, Kornfeld S. Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Mol Biol Cell. 2009;20:4381-9 pubmed publisher
    ..GlcNAc-1-phosphotransferase) and GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase ("uncovering enzyme" or UCE)...
  15. Chen F, Zhang Q, Fei S, Gu H, Yang L. Optimization of ultrasonic circulating extraction of samara oil from Acer saccharum using combination of Plackett-Burman design and Box-Behnken design. Ultrason Sonochem. 2017;35:161-175 pubmed publisher
    In this study, ultrasonic circulating extraction (UCE) technique was firstly and successfully applied for extraction of samara oil from Acer saccharum...
  16. Bossert S, Murray E, Blaimer B, Danforth B. The impact of GC bias on phylogenetic accuracy using targeted enrichment phylogenomic data. Mol Phylogenet Evol. 2017;111:149-157 pubmed publisher
    ..We investigated the impact of GC content on phylogeny reconstruction using in silico captured UCE data for the corbiculate bees (Hymenoptera: Apidae)...
  17. Warnefors M, Hartmann B, Thomsen S, Alonso C. Combinatorial Gene Regulatory Functions Underlie Ultraconserved Elements in Drosophila. Mol Biol Evol. 2016;33:2294-306 pubmed publisher
    ..Our data indicate that Drosophila UCEs are hubs for gene regulatory functions and suggest that UCE sequence invariance originates from their combinatorial roles in gene control...
  18. Rojo Gutiérrez M, Flores Ruvalcaba C, Mellado Ábrego J, Castillo Narváez G, Ramírez Rojo D. [Usefulness of studies looking for autoimmunity in patients with spontaneous chronic urticaria]. Rev Alerg Mex. 2015;62:175-81 pubmed
    ..The correlation between ASST and AAT was not significant. Most patients were women UCE and only 4 had positive ASST, but this does not correlate with the presence of anti-thyroid antibodies...
  19. Shoiab I, Danford D, Li L, Abdullah I, Hammel J, Kutty S. Predischarge Transthoracic Echocardiography after Surgery for Congenital Heart Disease: A Routine with a Reason?. J Am Soc Echocardiogr. 2015;28:1030-5 pubmed publisher
    ..27-0.43). Sixty-four patients (14%) had UCEs. Univariate analysis revealed that UCE were more frequent in patients with diagnoses and surgical procedures of high complexity...
  20. Persons N, Hosner P, Meiklejohn K, Braun E, Kimball R. Sorting out relationships among the grouse and ptarmigan using intron, mitochondrial, and ultra-conserved element sequences. Mol Phylogenet Evol. 2016;98:123-32 pubmed publisher
    ..among genera and assess paraphyly of one genus more rigorously, we then added over 3000 ultra-conserved element (UCE) loci (over 1.7million bp) gathered using Illumina sequencing...
  21. Onder S, Taskin O, Sen F, Topuz S, Kucucuk S, Sözen H, et al. High expression of SALL4 and fascin, and loss of E-cadherin expression in undifferentiated/dedifferentiated carcinomas of the endometrium: An immunohistochemical and clinicopathologic study. Medicine (Baltimore). 2017;96:e6248 pubmed publisher
    Undifferentiated/dedifferentiated endometrial carcinomas (UCE/DCEs) of the endometrium are rare tumors with poor prognosis. There are few clinicopathologic studies with detailed immunohistochemical analysis regarding UCE/DCEs...
  22. Hyun Y, Lee K, Oh K, Ahn C, Park S, Chae D, et al. Serum adiponectin and protein-energy wasting in predialysis chronic kidney disease. Nutrition. 2017;33:254-260 pubmed publisher
    ..8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg...
  23. Frehlich M, Dominguez L, Atluri S, Radhu N, Sun Y, Daskalakis Z, et al. Unbiased cluster estimation of electrophysiological brain response. J Neurosci Methods. 2016;271:43-9 pubmed publisher
    ..Rather than selecting a single threshold value, unbiased cluster estimation (UCE) computes a significance distribution across all possible threshold values to provide an unbiased overall ..
  24. Blaimer B, Brady S, Schultz T, Lloyd M, Fisher B, Ward P. Phylogenomic methods outperform traditional multi-locus approaches in resolving deep evolutionary history: a case study of formicine ants. BMC Evol Biol. 2015;15:271 pubmed publisher
    ..Moreover, UCE data on invertebrates, including insects, are sparse...
  25. Shaffer H, McCartney Melstad E, Near T, Mount G, Spinks P. Phylogenomic analyses of 539 highly informative loci dates a fully resolved time tree for the major clades of living turtles (Testudines). Mol Phylogenet Evol. 2017;115:7-15 pubmed publisher
    ..a target capture array specifically for living turtles, compare its efficiency to an ultraconserved element (UCE) dataset, and present a time-calibrated molecular phylogeny based on 539 nuclear loci sequenced from 26 species ..
  26. Kwon O, Park S. Interictal fatigue and its predictors in epilepsy patients: A case-control study. Seizure. 2016;34:48-53 pubmed publisher
    ..270 consecutive adult patients with epilepsy and categorized them into three subgroups: uncontrolled epilepsy (UCE), well-controlled epilepsy (WCE), and poorly controlled epilepsy (PCE)...
  27. Zheng C, Zou X, Lin H, Zhao B, Zhang M, Luo C, et al. miRNA-185 regulates the VEGFA signaling pathway in dairy cows with retained fetal membranes. Theriogenology. 2018;110:116-121 pubmed publisher
    ..Uterine caruncle epithelial (UCE) cells were cultured by the explant culture method, further purified, and subsequently treated with miRNA-185 ..
  28. Branstetter M, Ješovnik A, Sosa Calvo J, Lloyd M, Faircloth B, Brady S, et al. Dry habitats were crucibles of domestication in the evolution of agriculture in ants. Proc Biol Sci. 2017;284: pubmed publisher
    ..Here, we use phylogenomic data from ultra-conserved element (UCE) loci to reconstruct the evolutionary history of fungus-farming ants, reduce topological uncertainty, and identify ..
  29. Chen F, Zhang Q, Liu J, Gu H, Yang L. An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. Ultrason Sonochem. 2017;37:267-278 pubmed publisher
    Ultrasonic circulating extraction (UCE) approach was developed for effective extraction of orientin and vitexin from the flowers of Trollius chinensis successfully...
  30. Zhang W, Huang J, Wang W, Li Q, Chen Y, Feng W, et al. Extraction, purification, characterization and antioxidant activities of polysaccharides from Cistanche tubulosa. Int J Biol Macromol. 2016;93:448-458 pubmed publisher
    An efficient ultrasonic-cellulase-assisted extraction (UCE) of Cistanche tubulosa polysaccharide (CTP) was established. The response surface methodology based on Box-Behnken Design was employed to further optimize extraction conditions...
  31. Yan Y, Du Y, Wang G, Li K. Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin. Sci Rep. 2017;7:17761 pubmed publisher
    ..protein of nucleolus repressed RNA Pol I-dependent transcription via establishing hyper-methylation in the UCE of rRNA gene promoter...
  32. Zarza E, Faircloth B, Tsai W, Bryson R, Klicka J, McCormack J. Hidden histories of gene flow in highland birds revealed with genomic markers. Mol Ecol. 2016;25:5144-5157 pubmed publisher
    ..g. ABBA/BABA tests). Results based on 4303 UCE loci and 2500 informative SNPs are consistent with varying degrees of gene flow among highland areas...
  33. Branstetter M, Danforth B, Pitts J, Faircloth B, Ward P, Buffington M, et al. Phylogenomic Insights into the Evolution of Stinging Wasps and the Origins of Ants and Bees. Curr Biol. 2017;27:1019-1025 pubmed publisher
    ..We used ultraconserved element (UCE) phylogenomics [7, 12] to resolve relationships among stinging-wasp families, gathering sequence data from >800 ..
  34. Pirnie S, Osman A, Zhu Y, Carmichael G. An Ultraconserved Element (UCE) controls homeostatic splicing of ARGLU1 mRNA. Nucleic Acids Res. 2017;45:3473-3486 pubmed publisher
    ..Furthermore, ARGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alternative exon...
  35. Chakrabarty P, Faircloth B, Alda F, Ludt W, McMahan C, Near T, et al. Phylogenomic Systematics of Ostariophysan Fishes: Ultraconserved Elements Support the Surprising Non-Monophyly of Characiformes. Syst Biol. 2017;66:881-895 pubmed publisher
    ..We also explore incongruence between results from different UCE data sets, issues of orthology, and the use of morphological characters in combination with our molecular data...
  36. Gilbert P, Chang J, Pan C, Sobel E, Sinsheimer J, Faircloth B, et al. Genome-wide ultraconserved elements exhibit higher phylogenetic informativeness than traditional gene markers in percomorph fishes. Mol Phylogenet Evol. 2015;92:140-6 pubmed publisher
    ..Although UCE datasets typically contain a much larger number of loci and sites than more traditional datasets of PCR-amplified, ..
  37. Lima M, Silva Júnior J, Cerny D, Buckner J, Aleixo A, Chang J, et al. A phylogenomic perspective on the robust capuchin monkey (Sapajus) radiation: First evidence for extensive population admixture across South America. Mol Phylogenet Evol. 2018;124:137-150 pubmed publisher
    ..robustus and S. xanthosternos as distinct species. However, the UCE phylogeny lumped the putative species S. cay, S. libidinosus, S. apella, S. macrocephalus, and S...
  38. Niu L, Tao Y, Chen M, Fu Q, Li C, Dong Y, et al. Selection of Reliable Reference Genes for Gene Expression Studies of a Promising Oilseed Crop, Plukenetia volubilis, by Real-Time Quantitative PCR. Int J Mol Sci. 2015;16:12513-30 pubmed publisher
    ..The results showed that ubiquitin-conjugating enzyme (UCE), actin (ACT) and phospholipase A22 (PLA) were the most stable genes in Sacha inchi seedlings...
  39. Zaitseva N, Alekseev S, Zaitsev V, Raks V. Solid-Phase Spectrophotometric Analysis of 1-Naphthol Using Silica Functionalized with m-Diazophenylarsonic Acid. Nanoscale Res Lett. 2016;11:149 pubmed publisher
    The m-aminophenylarsonic acid (m-APAA) was immobilized onto the silica gel surface with covalently grafted quaternary ammonium groups via ion exchange...
  40. Wang N, Hosner P, Liang B, Braun E, Kimball R. Historical relationships of three enigmatic phasianid genera (Aves: Galliformes) inferred using phylogenomic and mitogenomic data. Mol Phylogenet Evol. 2017;109:217-225 pubmed publisher
    ..among Ithaginis, Lerwa, Rhizothera, and their phasianid relatives, we used 3692 ultra-conserved element (UCE) loci and complete mitogenomes from 19 species including previously hypothesized relatives of the three focal ..
  41. Harrington R, Faircloth B, Eytan R, Smith W, Near T, Alfaro M, et al. Phylogenomic analysis of carangimorph fishes reveals flatfish asymmetry arose in a blink of the evolutionary eye. BMC Evol Biol. 2016;16:224 pubmed
    ..We tackle this phylogenetic problem using a sequence dataset comprising more than 1,000 ultraconserved DNA element (UCE) loci covering 45 carangimorphs, the broader clade containing flatfishes and several other specialized lineages ..
  42. Baek E, Yoon J, Palukaitis P. Validation of reference genes for quantifying changes in gene expression in virus-infected tobacco. Virology. 2017;510:29-39 pubmed publisher ribosomal protein L25 > ?-Tubulin > Actin, and the least stable genes Ubiquitin-conjugating enzyme (UCE) < PP2A < GAPDH...
  43. Guo Y, Wang C, Miao X, Chen S, Qian Y, Li G, et al. Upregulation of uc.189 in patients with esophageal squamous cell carcinoma and its clinicopathologic value. Pathol Res Pract. 2017;213:1400-1403 pubmed publisher
    ..Until now, the role of the UCE uc.189 in human cancers remains undefined and the clinical significance of uc...
  44. Chen H, Xu J, Zhou Y, Gao Y, Wang G, Xia J, et al. Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC Genet. 2015;16:7 pubmed publisher
    ..Our results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population. ..
  45. Mori S, Tagaya N, Hamada K, Nakagawa A, Sawada T, Honma K, et al. Undifferentiated carcinoma of the esophagus with rapid growth of lymph node. A case report and review of the literature. Tumori. 2008;94:411-5 pubmed
    We present a case of undifferentiated carcinoma of the esophagus (UCE) treated with chemotherapy consisting of 5-fluorouracil plus nedaplatin and radiotherapy...
  46. Raza M, Domingues C, Webster R, Sainz E, Paris E, Rahn R, et al. Mucolipidosis types II and III and non-syndromic stuttering are associated with different variants in the same genes. Eur J Hum Genet. 2016;24:529-34 pubmed publisher
  47. Kornfeld R, Bao M, Brewer K, Noll C, Canfield W. Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1999;274:32778-85 pubmed
    ..It showed that our cDNA clone was missing only the 5'-untranslated region and initiator methionine and revealed that the human genomic DNA has the same exon organization as the mouse gene. ..
  48. Kang C, Drayna D. A role for inherited metabolic deficits in persistent developmental stuttering. Mol Genet Metab. 2012;107:276-80 pubmed publisher
    ..However these findings have opened several new lines of inquiry, including studies in mice carrying human stuttering mutations, that represent promising approaches to this disorder. ..
  49. Raza M, Mattera R, Morell R, Sainz E, Rahn R, Gutierrez J, et al. Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Am J Hum Genet. 2015;97:715-25 pubmed publisher
    ..These findings implicate deficits in intracellular trafficking in persistent stuttering. ..
  50. Do H, Lee W, Ghosh P, Hollowell T, Canfield W, Kornfeld S. Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 2002;277:29737-44 pubmed
    N-Acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, also known as "uncovering" enzyme (UCE), is localized in the trans-Golgi network, where it removes a covering N-acetylglucosamine from the mannose 6-phosphate ..
  51. Van Dam M, Lam A, Sagata K, Gewa B, Laufa R, Balke M, et al. Ultraconserved elements (UCEs) resolve the phylogeny of Australasian smurf-weevils. PLoS ONE. 2017;12:e0188044 pubmed publisher
    ..Finally, our results show that most loci required multiple partitions for nucleotide rate substitution, suggesting that single partitions may not be the optimal partitioning strategy to accommodate rate heterogeneity for UCE loci.
  52. Prebus M. Insights into the evolution, biogeography and natural history of the acorn ants, genus Temnothorax Mayr (hymenoptera: Formicidae). BMC Evol Biol. 2017;17:250 pubmed publisher
    ..two molecular datasets: a traditional multi-locus Sanger sequencing dataset, and an ultra-conserved element (UCE) dataset...
  53. Nair P, Schaub B, Huang K, Chen X, Murphy R, Griffith J, et al. Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme. J Cell Sci. 2005;118:2949-56 pubmed
    ..The identification of a trans-Golgi network exit signal in its cytoplasmic tail elucidates the trafficking pathway of uncovering enzyme, a crucial player in the process of lysosomal biogenesis. ..
  54. Lee W, Rohrer J, Kornfeld R, Kornfeld S. Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme. J Biol Chem. 2002;277:3544-51 pubmed
    ..These findings indicate that the YAYHPLQE motif is recognized at several sorting sites, including the trans-Golgi network, the plasma membrane, and the endosome. ..
  55. Rohrer J, Kornfeld R. Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network. Mol Biol Cell. 2001;12:1623-31 pubmed
    A crucial step in lysosomal biogenesis is catalyzed by "uncovering" enzyme (UCE), which removes a covering N-acetylglucosamine from the mannose 6-phosphate (Man-6-P) recognition marker on lysosomal hydrolases...
  56. Kornfeld R, Bao M, Brewer K, Noll C, Canfield W. Purification and multimeric structure of bovine N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1998;273:23203-10 pubmed
  57. Ren H, Wu X, Lyu Y, Zhou H, Xie X, Zhang X, et al. Selection of reliable reference genes for gene expression studies in Botrytis cinerea. J Microbiol Methods. 2017;142:71-75 pubmed publisher
    ..actin (ACT), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ubiquitin (UBQ), ubiquitin-conjugating enzyme (UCE), ?-tubulin (?-TUB) and ?-tubulin (?-TUB) were selected to test their expression stabilities in B...
  58. Page T, Zhao K, Tao L, Miller A. Purification and characterization of human lymphoblast N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. Glycobiology. 1996;6:619-26 pubmed
    ..Acetamino-deoxycastanospermine was a potent inhibitor of the human enzyme with a Ki of 0.35 microM, while N-acetylglucosamine phosphate (Ki 1.58 mM) and N-acetylglucosamine (Ki 5.1 mM) inhibited the enzyme to a lesser degree. ..
  59. Kazemi N, Estiar M, Fazilaty H, Sakhinia E. Variants in GNPTAB, GNPTG and NAGPA genes are associated with stutterers. Gene. 2018;647:93-100 pubmed publisher
    ..This finding may challenge the current belief that variations causing stuttering are at different sites and have less severe consequences than genetic changes that cause ML-ll and ML-lll. ..
  60. Hulsey C, Zheng J, Faircloth B, Meyer A, Alfaro M. Phylogenomic analysis of Lake Malawi cichlid fishes: Further evidence that the three-stage model of diversification does not fit. Mol Phylogenet Evol. 2017;114:40-48 pubmed publisher
    ..Using several reconstruction methods and 1037 ultra-conserved element (UCE) markers, we recovered a molecular phylogeny that confidently resolved relationships among most of the Malawi ..
  61. Ticinesi A, Guerra A, Allegri F, Nouvenne A, Cervellin G, Maggio M, et al. Determinants of calcium and oxalate excretion in subjects with calcium nephrolithiasis: the role of metabolic syndrome traits. J Nephrol. 2018;31:395-403 pubmed publisher
    The association of metabolic syndrome (MetS) traits with urinary calcium (UCE) or oxalate excretion (UOE) is uncertain in calcium stone formers (CSFs). Our aim was to investigate this association in a large group of Caucasian CSFs...
  62. Das D, Lee W, Grant J, Chiu H, Farr C, Vance J, et al. Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme. J Biol Chem. 2013;288:16789-99 pubmed publisher
    ..glycoprotein N-acetylglucosamine-1-phosphodiester ?-N-acetylglucosaminidase ("uncovering enzyme" (UCE))...
  63. Zucker M, Harvey M, Oswald J, Cuervo A, Derryberry E, Brumfield R. The Mouse-colored Tyrannulet (Phaeomyias murina) is a species complex that includes the Cocos Flycatcher (Nesotriccus ridgwayi), an island form that underwent a population bottleneck. Mol Phylogenet Evol. 2016;101:294-302 pubmed publisher
    ..The 46 UCE loci containing alleles that are fixed between the two species are widely distributed across the genome, which ..
  64. Lee J, Pierce M. Purification and characterization of human serum N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. Arch Biochem Biophys. 1995;319:413-25 pubmed
    ..The Km values for UDP-GlcNAc and GlcNAc-P-Man alpha Me were 0.94 and 0.45 mM, respectively. Over 77% of enzyme activity remained after incubation for 10 min at 70 degrees C, demonstrating an unusual thermostability of the serum enzyme. ..