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| MAN2B1SummaryGene Symbol: MAN2B1 Description: mannosidase, alpha, class 2B, member 1 Alias: LAMAN, MANB, lysosomal acid alpha-mannosidase, lysosomal alpha-mannosidase, mannosidase alpha-B, mannosidase, alpha B, lysosomal Species: human Top Publications
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Publications
Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectinMelanie L Hart
Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, 1563 W Congress Parkway, Chicago, IL 60612, USA
J Gen Virol 84:353-60. 2003..This study shows that specific alterations of the N-linked carbohydrates on HIV gp120/gp41 can enhance MBL-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL...- Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral responseA Bolmstedt
Department of Clinical Virology, University of Goteborg, Sweden
J Acquir Immune Defic Syndr Hum Retrovirol 12:213-20. 1996..These data indicated that elimination of the three N-linked glycans from gp160 resulted in an altered local antigenic conformation but did not uncover hidden neutralization epitopes, broadening the immune response... 
Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomainE Fenouillet
Laboratoire de Biologie et Génétique des Pathologies Immunitaires, CNRS URA 1463, France
J Virol 67:150-60. 1993....- Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1D C Montefiori
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN 37232
Proc Natl Acad Sci U S A 85:9248-52. 1988..These results demonstrate that protein N-glycosylation is critical to the pathogenesis of HIV-1 at the levels of viral infectivity and cytopathicity but not at the level of virus replication or of host-cell infectibility... - Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cellsC K Leonard
Department of Medicinal Chemistry, Genentech, Inc, South San Francisco, California 94080
J Biol Chem 265:10373-82. 1990.... - Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope functionD A Dedera
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
Virology 187:377-82. 1992.... - Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulumA Land
Department of Bio Organic Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Biochimie 83:783-90. 2001..Here we present an overview of the present knowledge on the folding process of the heavily glycosylated human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein in the ER... - A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917Lubomir Grozdanov
Institut für Molekulare Infektionsbiologie, Bayerische Julius Maximilians Universität Würzburg, Rontgenring 11, D 97070 Wurzburg, Germany
J Bacteriol 184:5912-25. 2002..The DNA sequence of the wb(*) gene cluster (11 kb) exhibits no homology to known DNA sequences except manC and manB. Comparison of the genetic structures of the wb(*)(O6) (wb(*) from serotype O6) determinants of strain Nissle 1917 .. - DNA polymorphism analysis of Brucella lipopolysaccharide genes reveals marked differences in O-polysaccharide biosynthetic genes between smooth and rough Brucella species and novel species-specific markersMichel S Zygmunt
INRA, UR1282, Infectiologie Animale et Sante Publique, IASP, Nouzilly, France
BMC Microbiol 9:92. 2009..In smooth brucellae, lipopolysaccharide is made of lipid A-core oligosaccharide and N-formylperosamine O-polysaccharide. B. ovis and B. canis (rough species) lack the O-polysaccharide... - Cloning, sequence, expression and characterization of human beta-mannosidaseZahoor Qadir Samra
Institute of Biochemistry and Biotechnology, Quaid i Azam Campus, University of the Punjab, Lahore, Pakistan
Acta Biochim Pol 55:479-90. 2008Beta-mannosidase (EC 3.2.1.25, MANB) dissects the non-reducing end of N-linked mannose moieties of glycoproteins in eukaryotic cells. The human beta-mannosidase gene was amplified by RT-PCR, cloned and sequenced... 
Modulation of guanosine 5'-diphosphate-D-mannose metabolism in recombinant Escherichia coli for production of guanosine 5'-diphosphate-L-fucoseWon Heong Lee
Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Republic of Korea
Bioresour Technol 100:6143-8. 2009..coli BL21star(DE3) strain overexpressing manB, manC, gmd and wcaG genes...- Alpha-mannosidosisDag Malm
Department of Gastroenterology, University Hospital of North Norway, NO 9038, Norway
Orphanet J Rare Dis 3:21. 2008..Alpha-mannosidosis is inherited in an autosomal recessive fashion and is caused by mutations in the MAN2B1 gene located on chromosome 19 (19 p13.2-q12)... - Low-dose photons modify liver response to simulated solar particle event protonsDaila S Gridley
Department of Radiation Medicine, Molecular Radiation Biology Laboratories, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
Radiat Res 169:280-7. 2008..those up-regulated after either photons or the simulated SPE alone (photons, Cstb; simulated SPE, Dctn2, Khsrp, Man2b1, Snrp70; photons + simulated SPE, Casp1, Col1a1, Hspcb, Il6st, Rpl28, Spnb2)... - Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulenceMiao Hsia Lin
Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 106, Taiwan
Mol Cell Proteomics 8:2613-23. 2009..three of the identified tyrosine phosphorylated proteins, namely protein-tyrosine kinase (Wzc), phosphomannomutase (ManB), and undecaprenyl-phosphate glycosyltransferase (WcaJ), were found to be distributed in the cps locus and thus .. - Comparative transcriptional study of the putative mannose donor biosynthesis genes in virulent Mycobacterium tuberculosis and attenuated Mycobacterium bovis BCG strainsTracy L Keiser
Center for Microbial Interface Biology, The Ohio State University, 460 W 12th Avenue, 1004 Biomedical Research Tower, Columbus, OH 43210, USA
Infect Immun 79:4668-73. 2011..Results for M. tuberculosis extracted from within macrophages show that whiB2 is highly expressed and manB and manC are moderately expressed during infection... - Characterisation of Yersinia pestis isolates from natural foci of plague in the Republic of Georgia, and their relationship to Y. pestis isolates from other countriesT Revazishvili
Emerging Pathogens Institute and Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Clin Microbiol Infect 14:429-36. 2008..using multilocus sequence typing (MLST), based on sequence data for the 16S rRNA, hsp60, glnA, gyrB, recA, manB, thrA and tmk loci. Four virulence gene loci (caf1, lcrV, psaA and pla) were also sequenced and analysed... - Identification of type 3 fimbriae in uropathogenic Escherichia coli reveals a role in biofilm formationCheryl Lynn Y Ong
School of Molecular and Microbial Sciences, Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Australia
J Bacteriol 190:1054-63. 2008..Mutants containing insertions in genes involved in O antigen synthesis (rmlC and manB) and capsule synthesis (kpsM) possessed enhanced biofilm phenotypes... - Early onset alpha-mannosidosis with slow progression in three Hispanic malesMichael J Lyons
Greenwood Genetic Center, Greenwood, South Carolina, USA
Dev Med Child Neurol 49:854-7. 2007..They were aged between 6 and 24 years at their last assessment. Homozygous mutations in the MAN2B1 gene were found in all three patients, one of which is a newly reported mutation... - Limited genetic diversity in Salmonella enterica serovar Enteritidis PT13Adam B Olson
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
BMC Microbiol 7:87. 2007..Enteritidis PT13... - Development of an efficient production method for beta-mannosidase by the creation of an overexpression system in Aspergillus aculeatusS Kanamasa
Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa, Japan
Lett Appl Microbiol 45:142-7. 2007To develop an overexpression system in Aspergillus aculeatus in order to establish an efficient overproduction method of beta-mannosidase (MANB). - Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding propertiesMeenakshi Venkatesan
Ontario Cancer Institute, Division of Cancer Genomics and Proteomics, Toronto, Ontario M5G 1L7, Canada
Protein Sci 18:2242-51. 2009..the lysosomal mannosidase family, the broad substrate specificity enzyme human lysosomal alpha-mannosidase (hLM, MAN2B1) and the human core alpha-1, 6-specific mannosidase (hEpman, MAN2B2) act in a complementary fashion on different .. - Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolatesHung Yu Shu
Department of Bioscience Technology, Chang Jung Christian University, Tainan County, Taiwan, ROC
Microbiology 155:4170-83. 2009..The rmlBADC genes were found in CPS K9-positive, K14-positive and K52-positive strains, while manC and manB were found in K1, K2, K5, K14, K62 and two undefined strains... - Human α-mannosidase produced in transgenic tobacco plants is processed in human α-mannosidosis cell linesFrancesca De Marchis
Institute of Plant Genetics, Italian National Council of Research CNR, Perugia, Italy
Plant Biotechnol J 9:1061-73. 2011Deficiency in human lysosomal α-mannosidase (MAN2B1) results in α-mannosidosis, a lysosomal storage disorder; patients present a wide range of neurological, immunological, and skeletal symptoms caused by a multisystemic accumulation of .. - Human lysosomal α-D-mannosidase regulation in promyelocytic leukaemia cellsLorena Urbanelli
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Biosci Rep 31:477-87. 2011..The MAN2B1 transcript level correlates with enzyme activity, indicating a transcriptional up-regulation of the α-D-.. - Molecular and cellular characterization of novel {alpha}-mannosidosis mutationsElina Kuokkanen
Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
Hum Mol Genet 20:2651-61. 2011Mannosidosis is a lysosomal storage disorder caused by mutations in the MAN2B1 gene. The clinical presentation of α-mannosidosis is variable, but typically includes mental retardation, skeletal abnormalities and immune deficiency... - Glycoside hydrolase inventory drives plant polysaccharide deconstruction by the extremely thermophilic bacterium Caldicellulosiruptor saccharolyticusAmy L VanFossen
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
Biotechnol Bioeng 108:1559-69. 2011..CelA-ManB (Csac_1076-Csac_1080) encodes four multi-domain, extracellular GHs, including CelB (Csac_1078), a 118 kDa .. - Co-transcription of the celC gene cluster in Clostridium thermocellumMichael Newcomb
Department of Chemical Engineering, University of Rochester, Room 206 Gavett Hall, Rochester, NY 14627 0166, USA
Appl Microbiol Biotechnol 90:625-34. 2011..We mapped the transcripts of the six-gene cluster celC-glyR3-licA-orf4-manB-celT and determined their transcription initiation sites by primer extension... - A celluloytic complex from Clostridium cellulovorans consisting of mannanase B and endoglucanase E has synergistic effects on galactomannan degradationSang Duck Jeon
School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
Appl Microbiol Biotechnol 90:565-72. 2011..In this study, a mannanase gene, manB from C. cellulovorans, was expressed in Escherichia coli. The optimal pH of a purified enzyme was around pH 7... - Crystallization and preliminary crystallographic analysis of β-mannanase from Bacillus licheniformisChomphunuch Songsiriritthigul
Synchrotron Light Research Institute, Nakhon Ratchasima, Thailand
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:217-20. 2011The mannan endo-1,4-β-mannosidase (ManB) from Bacillus licheniformis strain DSM13 was overexpressed in Escherichia coli... - Synthesis of GDP-mannose using coupling fermentation of recombinant Escherichia coliJia Honghong
Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People s Republic of China
Biotechnol Lett 33:1145-50. 2011Glucokinase (glk), phosphomannomutase (manB), and mannose-1-phosphate guanylytransferase (manC) are needed for the biosynthesis of GDP-mannose. A recombinant E... - Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophagesXin He Lai
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 5:e11857. 2010..Surprisingly, we found that F. novicida with mutations in four genes (lpcC, manB, manC and kdtA) were taken up by and killed macrophages at a much higher rate than the parent strain, even upon .. - The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: analysis of the complete known Ser/Thr kinome suggests the existence of novel kinasesSebastian R Schmidl
Department of General Microbiology, Georg August Universitat Gottingen, Grisebachstrasse 8, D 37077 Gottingen, Germany
Mol Cell Proteomics 9:1228-42. 2010..Only one single protein with an identified phosphorylation site, a phosphosugar mutase (ManB in M... - Loss of phosphomannomutase activity enhances actinorhodin production in Streptomyces coelicolorYung Hun Yang
School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
Appl Microbiol Biotechnol 86:1485-92. 2010Phosphomannomutase (ManB), whose main function is the conversion of mannose-6-phosphate to mannose-1-phosphate, is involved in biosynthesis of GDP-mannose for numerous processes such as synthesis of structural carbohydrates, production of .. - A multi-species comparative structural bioinformatics analysis of inherited mutations in alpha-D-mannosidase reveals strong genotype-phenotype correlationJaved Mohammed Khan
Department of Chemistry and Biomolecular Sciences and ARC center of excellence in Bioinformatics, Macquarie University, NSW 2109, Australia
BMC Genomics 10:S33. 2009..Mutations in the gene (MAN2B1) encoding lysosomal alpha-D-mannosidase cause improper coding, resulting in dysfunctional or non-functional .. - Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosisMarkus Damme
Abt Biochemie II, Georg August Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Mol Cell Biol 30:273-83. 2010Alpha-mannosidosis is caused by the genetic defect of the lysosomal alpha-d-mannosidase (LAMAN), which is involved in the breakdown of free alpha-linked mannose-containing oligosaccharides originating from glycoproteins with N-linked .. - [Sequence of Escherichia coli O11 O-antigen gene cluster and identification of molecular markers specific to O11]Wei Wang
TEDA School of Biological Sciences, Nankai University, Tianjin 300457, China
Wei Sheng Wu Xue Bao 46:341-6. 2006..glucosamine-4-epimerase gene (gne), genes responsible for the biosynthesis of GDP-L-fucose (gmd, fcl, gmm, manC, manB), glycosyl transferase genes, O-unit flippase gene (wzx) and O-antigen polymerase gene (wzy)... - Funtional characterization of four novel MAN2B1 mutations causing juvenile onset alpha-mannosidosisM G Pittis
Unità Malattie Metaboliche, IRCCS Burlo Garofolo, Trieste, Italy
Clin Chim Acta 375:136-9. 2007..Finally, the c.2660delC causes a frameshift introducing a premature stop codon (p.T887SfsX45), presuming to be a severe mutation... - [Occurrence of selected genes of the Klebsiella pneumoniae clusters waa and wb for lipolysaccharide synthesis in reference and epidemic strains]Rafał Gierczyński
Zakład Bakteriologii PZH w Warszawie
Med Dosw Mikrobiol 57:383-93. 2005..and 6 casual isolates for the existence of 7 (waaA, waaE, waaL, waaQ, waaZ, waaX and uge) and 4 (wbdA, wbdC, manB, wbbO) genes of the waa and wb clusters for LPS biosynthesis... - Genomic structure of the human lysosomal alpha-mannosidase gene (MANB)H M Riise
Department of Medical Biochemistry, Institute of Medical Biology, University of Tromsø, Norway
Genomics 42:200-7. 1997Lysosomal alpha-mannosidase (LAMAN) (EC 3.2.1.24) is an exoglycosidase involved in the ordered degradation of N-linked oligosaccharides. Lack of LAMAN activity leads to the lysosomal storage disorder alpha-mannosidosis (MIM No. 248500)... - alpha-Mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblingsO Nilssen
Department of Medical Genetics, University Hospital and University of Tromso, Norway
Hum Mol Genet 6:717-26. 1997..autosomal recessive lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase (LAMAN) (EC 3.2.1.24)... - Polymorphism, duplication, and IS1-mediated rearrangement in the chromosomal his-rfb-gnd region of Escherichia coli strains with group IA and capsular K antigensJ Drummelsmith
Department of Microbiology, University of Guelph, Ontario, Canada
J Bacteriol 179:3232-8. 1997..Previously, we reported a duplication of the manC-manB genes, encoding enzymes involved in GDP-mannose formation, upstream of rfb in strain E69 (P. Jayaratne et al., J... - Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradationM J Papandreou
CNRS, UMR 6560, IFR Jean Roche, Faculte de Medecine Nord, Marseille, France
FEBS Lett 406:191-5. 1997..Thus, partial deglycosylation increases Env sensitivity to proteases but only its total deglycosylation alters its stability... - Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidaseY F Liao
Complex Carbohydrate Research Center and the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
J Biol Chem 271:28348-58. 1996..Human chromosome mapping of the mannosidase gene confirmed that the functional gene maps to the MANB locus on chromosome 19... - Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surfaceH Hu
Department of Viral Infection, Institute of Medical Science, University of Tokyo, Minato ku, Japan
J Virol 70:7462-70. 1996..Thus, the sialylation catalyzed by host cell pathways appeared to reduce the infectivity of human and nonhuman primate lentiviruses. Our results further suggested that desialylation would help increase the titers of HIV-based vectors... - Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNAV L Nebes
Dept of Ophthalmology, Allegheny Singer Research Institute, Pittsburgh, PA 15212
Biochem Biophys Res Commun 200:239-45. 1994..The cDNA maps proximal to the centromere on chromosome 19q, the same locus as the MANB gene... - Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase BC Emiliani
Dipartimento di Biologia Cellulare e Molecolare, Universita degli Studi di Perugia, Italy
Biochem J 305:363-6. 1995..Res. Commun. 200, 239-245] and to locate the position of this polypeptide within the total deduced amino acid sequence. This finding will therefore provide a firm foundation for the characterization of alpha-mannosidosis mutations... - Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteinsH A Blough
Biochem Biophys Res Commun 141:33-8. 1986..The reverse transcriptase was not affected by the compounds. Glycosylation inhibitors may be considered for the chemotherapy of AIDS or AIDS-related complex, or chemoprophylaxis of HIV-positive individuals... - Regional assignment of five genes on human chromosome 19Y Kaneda
Chromosoma 95:8-12. 1987..chromosome 19 (PVS, E11S and RDRC) were lost in HM76Dd40-6, while six other genes (C3, LDLR, EF2, GPI, PEPD and MANB) were retained... - Electrophoretic abnormalities of lysosomal enzymes in mucolipidosis fibroblast linesM J Champion
Am J Hum Genet 29:149-63. 1977..These results are consistent with the mucolipidosis defect(s) being associated with abnormal post-translatinal processing of multiple lysosomal enzymes and adenosine deaminase-d... - Cloning, expression, purification, and characterization of the murine lysosomal acid alpha-mannosidaseR K Merkle
Complex Carbohydrate Research Center and the Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
Biochim Biophys Acta 1336:132-46. 1997..5 kb RNA transcript in all murine tissues tested. A minor transcript of 5.4 kb was also detected in some murine tissues similar to the alternatively spliced transcripts that have been previously identified in human tissues... - Characterization of the human MANB gene encoding lysosomal alpha-D-mannosidaseN Wakamatsu
First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan
Gene 198:351-7. 1997Genomic clones of human MANB gene encoding the lysosomal enzyme, alpha-mannosidase, have been isolated, sequenced and analyzed. The human MANB gene spans approximately 22 kb and consists of 24 exons... - Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7Z X Gu
Department of Animal Sciences, University of Wisconsin Madison, 53706, USA
Cytogenet Cell Genet 79:225-7. 1997..oligomeric matrix protein (COMP), lymphoblastic leukemia derived sequence 1 (LYL1), lysosomal alpha-mannosidase (MANB), and RAS oncogene family member RAB3A... - Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessmentKaren Caeyenberghs
Laboratory of Biological Psychology, Department of Psychology, KU Leuven, Belgium
Neurobiol Dis 23:422-32. 2006alpha-Mannosidosis is a lysosomal storage disorder caused by lysosomal alpha-mannosidase (LAMAN) deficiency that leads to neurocognitive dysfunctions, psychotic symptoms and emotional changes in human patients... - Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophagesTravis R McCarthy
Department of Medicine and Molecular Virology, The Center for Microbial Interface Biology, and the Division of Infectious Diseases, The Ohio State University, Columbus, OH 43210, USA
Mol Microbiol 58:774-90. 2005..We conclude that MtmanB encodes a functional PMM involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with macrophage phagocytic receptors... - Sisters with alpha-mannosidosis and systemic lupus erythematosusMaki Urushihara
Department of Paediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, 770 8503 Tokushima, Japan
Eur J Pediatr 163:192-5. 2004Alpha-mannosidosis is an autosomal recessive disorder caused by deficiency of lysosomal alpha-mannosidase (LAMAN). Here, we report two sisters with alpha-mannosidosis who developed systemic lupus erythematosus (SLE)... - Characterization of human liver alpha-D-mannosidase purified by affinity chromatographyN C Phillips
Biochem J 153:579-87. 1976..These results validate the use of synthetic substrates for determining the mannosidosis genotype. They are also further evidence that mannosidosis is a lysosomal storage disease resulting from a deficiency of acidic alpha-mannosidase... - Molecular and biochemical characterization of endo-beta-mannanases from germinating coffee (Coffea arabica) grainsP Marraccini
Department of Plant Science, Nestle Research Centre, Tours, France
Planta 213:296-308. 2001..In the present paper, we report the cloning and sequencing of two endo-beta-mannanase cDNAs (manA and manB) by different strategies from Coffea arabica L.... - Molecular characterization of Lactobacillus plantarum genes for beta-ketoacyl-acyl carrier protein synthase III (fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesisP Kiatpapan
Department of Biotechnology, Graduate School of Engineering, Yamada oka, Suita, Osaka 565 0871, Japan
Appl Environ Microbiol 67:426-33. 2001..We identified six potential open reading frames, namely, manB, fabH, accB, accC, accD, and accA, in that order... - Characterization of a novel alpha-mannosidosis-causing mutation and its use in leukocyte genotyping after bone marrow transplantationH M Frostad Riise
Department of Medical Biochemistry, University of Tromsø, Norway
Hum Genet 104:106-7. 1999Alpha-Mannosidosis is a lysosomal storage disorder caused by deficiency of lysosomal alpha-mannosidase (LAMAN). Major symptoms include mental retardation, skeletal changes and recurrent infections... - Spectrum of mutations in alpha-mannosidosisT Berg
Department of Medical Genetics, University Hospital and University of Tromso, N 9037, Norway
Am J Hum Genet 64:77-88. 1999alpha-Mannosidosis is an autosomal recessive disorder caused by deficiency of lysosomal alpha-mannosidase (LAMAN)... - Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosisY Gotoda
First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan
Am J Hum Genet 63:1015-24. 1998..analysis or direct sequencing, to analyze the 24 exons and intron/exon boundaries of the alpha-mannosidase gene (MANB) from five patients... - Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1E Mantuano
Istituto di Medicina Sperimentale, CNR, Rome, Italy
Gene 215:153-7. 1998..2-distal 19p13.1 between MANB and JUNB... - Efficient recombinant expression and secretion of a thermostable GH26 mannan endo-1,4-beta-mannosidase from Bacillus licheniformis in Escherichia coliChomphunuch Songsiriritthigul
School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, Thailand
Microb Cell Fact 9:20. 2010..and has been used extensively for large-scale industrial production of various enzymes; however, there has been no previous report on the cloning and expression of mannan endo-1,4-beta-mannosidase gene (manB) from B. licheniformis. - Alpha-mannosidosis and mutational analysis in a Turkish patientAkgun Olmez
Section of Pediatric Nutrition and Metabolism, Hacettepe University Faculty of Medicine, Ankara, Turkey
Turk J Pediatr 45:46-50. 2003..Enzyme studies on white cells confirmed a deficiency of alpha-mannosidase activity, which was 2.6 micromol/g/hr. Her DNA analysis showed a S453Y mutation... - Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosisMichele Sbaragli
Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Perugia, Italy
Hum Mutat 25:320. 2005..on six Italian families with alpha-mannosidosis type II allowed the identification of five new mutations in the MAN2B1 gene: c.157G>T, c.562C>T, c.599A>T, c.293dupA, c.2402G>A (p.E53X, p.R188X, p.H200L, p.Y99VfsX61, p.G801D)... - Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteinsH Shimizu
AIDS Research Center, National Institute of Health, Tokyo, Japan
Jpn J Med Sci Biol 43:75-87. 1990..ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1... - Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression systemJ C Yeh
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190
Biochemistry 32:11087-99. 1993..These results demonstrate that N-glycosylation of rgp120 in the baculovirus expression system occurs at all potential sites and is site specific in terms of oligosaccharide structures...
Research Grants
- Gene Transfer and NMR Studies in Alpha-Mannosidosis BrainJohn H Wolfe; Fiscal Year: 2010..will use a cat model of human alpha- mannosidosis (AMD), caused by a mutation in the lysosomal alpha-mannosidase (LAMAN) gene...
- Gene Transfer and NMR Studies in Alpha-Mannosidosis BrainJohn H Wolfe; Fiscal Year: 2010..will use a cat model of human alpha- mannosidosis (AMD), caused by a mutation in the lysosomal alpha-mannosidase (LAMAN) gene...
- Gene transfer & NMR studies in alpha-mannosidosis brainJohn Wolfe; Fiscal Year: 2006..In this project we will study an inherited deficiency of acidic alpha-D-mannosidase (MANB), which results in the accumulation of undegraded mannose-rich oligosaccharides in cellular lysosomes, prominently ..
- Altered M. tuberculosis Mannosylation and the MacrophageLarry S Schlesinger; Fiscal Year: 2010..One such gene is M.tb manB which we have found encodes a functional phosphomannomutase. Overexpression of manB in M...
- IN UTERO TRANSPLANTATION FOR LYSOSOMAL STORAGE DISEASEJANIS ABKOWITZ; Fiscal Year: 2002..cells and in utero gene transfer (with FeLV-pseudotyped, retroviral vectors containing marker genes and/or MANB cDNA)...
- TB and Innate Immune Regulation of Lung MacrophagesLarry Schlesinger; Fiscal Year: 2009..abstract_text> ..
- Interdisciplinary Study of the Microbe-Host InterfaceLarry Schlesinger; Fiscal Year: 2007....
- Mycobacterium tuberculosis lipoarabinomannan metabolism within human macrophagesLarry Schlesinger; Fiscal Year: 2007..Characterization of intracellular ManLAM metabolism using biochemical means would represent a significant advance for the field in terms of identifying new molecular targets for diagnostics, therapies and vaccines. ..
- Altered Mycobacterium tuberculosis Mannosylation and the MacrophageLarry Schlesinger; Fiscal Year: 2007..The assembled investigators will combine techniques in genetics, biochemistry, and cell biology to accomplish the goals of this proposal. ..
- MACROPHAGE COMPLEMENT RECEPTORS IN TUBERCULOSISLarry Schlesinger; Fiscal Year: 2002..tb-MP interaction in order to enhance our understanding of disease pathogenesis. Ultimately these studies may help to define specific novel therapeutic targets. ..
- TB and Innate Immune Regulation of Lung MacrophagesLarry Schlesinger; Fiscal Year: 2007..abstract_text> ..