MAN1

Summary

Gene Symbol: MAN1
Description: LEM domain containing 3
Alias: MAN1, LEM domain-containing protein 3, inner nuclear membrane protein Man1, integral inner nuclear membrane protein
Species: human

Top Publications

  1. ncbi The Drosophila melanogaster LEM-domain protein MAN1
    Nicole Wagner
    Division of Electron Microscopy, Biocenter of the University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Eur J Cell Biol 85:91-105. 2006
  2. ncbi Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor
    Malini Mansharamani
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 280:13863-70. 2005
  3. ncbi Germline LEMD3 mutations are rare in sporadic patients with isolated melorheostosis
    Jan Hellemans
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Hum Mutat 27:290. 2006
  4. doi Novel and recurrent germline LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis
    Y Zhang
    Oxford University Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
    Clin Genet 75:556-61. 2009
  5. ncbi Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
    Jan Hellemans
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Nat Genet 36:1213-8. 2004
  6. pmc Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family
    Sevjidmaa Baasanjav
    Institute of Medical Genetics, Charite Berlin, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    BMC Med Genet 11:110. 2010
  7. ncbi Function and assembly of nuclear pore complex proteins
    K Bodoor
    Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
    Biochem Cell Biol 77:321-9. 1999
  8. ncbi XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos
    Shin Ichi Osada
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Development 130:1783-94. 2003
  9. ncbi Structural analysis of free N-glycans occurring in soybean seedlings and dry seeds
    Y Kimura
    Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Japan
    Biosci Biotechnol Biochem 64:1847-55. 2000
  10. ncbi LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins
    Andreas Brachner
    Department of Medical Biochemistry, Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Dr Bohrgasse 9 3, A 1030 Vienna, Austria
    J Cell Sci 118:5797-810. 2005

Scientific Experts

  • M F Gjerstorff
  • Xifeng Wu
  • Edna Ben-Asher
  • Y Zhang
  • Nicole Wagner
  • Robyn Roth
  • Bettina Burger
  • Sally Ann Lynch
  • M I Arenas
  • Masatoshi Goto
  • Howard Worman
  • Elizabeth E Rogers
  • E Delhaize
  • Yasushi Hiraoka
  • K L Bales
  • Yasuhiro Hirano
  • Luiza Bengtsson
  • Steven Mumm
  • Nadir M Maraldi
  • Katherine Wilson
  • Luis Estevez
  • Miriam Segura Totten
  • Katherine L Wilson
  • Andreas Brachner
  • Jan Hellemans
  • Yosef Gruenbaum
  • Ayelet Margalit
  • Roland Foisner
  • Sandrine Caputo
  • Miriam Segura-Totten
  • Kenneth K Lee
  • Feng Lin
  • Akihiko Ishimura
  • Bjorn Menten
  • Jun Liu
  • Shin Ichi Osada
  • Wei Wu
  • Emilie Kondé
  • Karen Buysse
  • Geert Mortier
  • Bernard Gilquin
  • Sophie Zinn-Justin
  • Teresa Costa
  • Frank Speleman
  • Sigal Shaklai
  • T Jooste
  • Candice Yam
  • Mary D Kinsella
  • Michael Reil
  • Alison D Walters
  • Babett Steglich
  • Ying Huang
  • W H Van Zyl
  • Alexander Lerich
  • Manuela Yuste-Chaves
  • Adam J Meyer
  • Sevjidmaa Baasanjav
  • Y Kimura
  • S Spengler
  • Caroline Gaudy-Marqueste
  • Magda Dubińska-Magiera
  • Anita Iyengar Stone
  • Michelle Yadegari
  • Petrus J van Zyl
  • Francesca Mari
  • Michael D Huber
  • Xiao Song Yang
  • Daniel J Anderson
  • Chi Hui Liang
  • Charlotta Buch
  • Annelies Dheedene
  • P Enarson
  • Josef Gotzmann
  • Stefanie E Grund
  • George Anadiotis
  • Carrie Fagerstrom
  • Barbara C McGillivray
  • Belinda S Pinto
  • H Kobayashi
  • Tatiana V Cohen
  • Lester Young
  • Matyas Gorjanacz
  • Ana R Couto
  • D Hershkovitz
  • Colin L Stewart
  • Robert Craigie
  • Cecilia Ostlund
  • Gideon Rechavi
  • Ninette Amariglio
  • Amos J Simon

Detail Information

Publications106 found, 100 shown here

  1. ncbi The Drosophila melanogaster LEM-domain protein MAN1
    Nicole Wagner
    Division of Electron Microscopy, Biocenter of the University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Eur J Cell Biol 85:91-105. 2006
    ..melanogaster LEM-domain protein encoded by the annotated gene CG3167 which is the putative ortholog to vertebrate MAN1. MAN1 of Drosophila (dMAN1) and vertebrates have the following properties in common...
  2. ncbi Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor
    Malini Mansharamani
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 280:13863-70. 2005
    b>MAN1 is a vertebrate nuclear inner membrane protein that inhibits Smad signaling downstream of transforming growth factor beta...
  3. ncbi Germline LEMD3 mutations are rare in sporadic patients with isolated melorheostosis
    Jan Hellemans
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Hum Mutat 27:290. 2006
    ..Somatic mosaicism for a LEMD3 mutation in the latter group was also not observed, and therefore we must conclude that the genetic defect in the majority of sporadic and isolated melorheostosis remains unknown...
  4. doi Novel and recurrent germline LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis
    Y Zhang
    Oxford University Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
    Clin Genet 75:556-61. 2009
    ..The genetic or epigenetic influences that are responsible for the development of melorheostosis require further investigation...
  5. ncbi Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
    Jan Hellemans
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Nat Genet 36:1213-8. 2004
    ..that we investigated were heterozygous with respect to a loss-of-function mutation in LEMD3 (also called MAN1), which encodes an inner nuclear membrane protein...
  6. pmc Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family
    Sevjidmaa Baasanjav
    Institute of Medical Genetics, Charite Berlin, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    BMC Med Genet 11:110. 2010
    ..The patients affected with both LEMD3 and EXT1 gene mutations displayed typical features of the osteopoikilosis. There were no additional skeletal manifestations detected however, various non-skeletal pathologies coincided in this group...
  7. ncbi Function and assembly of nuclear pore complex proteins
    K Bodoor
    Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
    Biochem Cell Biol 77:321-9. 1999
    ..assembly for a group of NPC components (CAN/Nup214, Nup153, POM121, p62 and Tpr) relative to the integral inner nuclear membrane protein LAP2 and the NPC membrane glycoprotein gp210...
  8. ncbi XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos
    Shin Ichi Osada
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Development 130:1783-94. 2003
    ..nuclear membrane protein, XMAN1, as a novel neuralizing factor that is encoded by the Xenopus ortholog of human MAN1. XMAN1 mRNA is expressed maternally, and appears to be restricted to the entire ectoderm at the early gastrula ..
  9. ncbi Structural analysis of free N-glycans occurring in soybean seedlings and dry seeds
    Y Kimura
    Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Japan
    Biosci Biotechnol Biochem 64:1847-55. 2000
    ..N-glycans (Man 9 approximately 5 GlcNAc1) in the soybean seedlings have a common core structural unit; Manalpha1-6(Man1-3)Manalpha1-6(Manalpha1-3)Ma nbeta1-4GlcNAc...
  10. ncbi LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins
    Andreas Brachner
    Department of Medical Biochemistry, Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Dr Bohrgasse 9 3, A 1030 Vienna, Austria
    J Cell Sci 118:5797-810. 2005
    The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the nucleoplasm...
  11. pmc Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14
    Bjorn Menten
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    J Med Genet 44:264-8. 2007
    ..The observation of osteopoikilosis lesions should facilitate recognition of this new microdeletion syndrome among children with failure to thrive, short stature and learning disabilities...
  12. ncbi The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac
    Tatiana V Cohen
    Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick MD 21702, USA
    Development 134:1385-95. 2007
    b>MAN1 is an integral protein of the inner nuclear membrane of the nuclear envelope (NE)...
  13. ncbi Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics
    T Dechat
    Department of Biochemistry and Molecular Cell Biology, Biocenter, Vienna, A 1030, Austria
    J Struct Biol 129:335-45. 2000
    ..LAP2 isoforms have been found to share a homologous approximately 40 amino acid long region, the LEM domain, with nuclear membrane proteins MAN1 and emerin, which has been implicated in Emery-Dreifuss muscular dystrophy.
  14. pmc Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans
    Ayelet Margalit
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    J Cell Biol 178:661-73. 2007
    ..factor (BAF) binds double-stranded DNA, selected histones, transcription regulators, lamins, and LAP2-emerin-MAN1 (LEM) domain proteins...
  15. ncbi Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF
    Kathryn E Tifft
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA
    Exp Cell Res 312:478-87. 2006
    ..g., LAP2beta, emerin, MAN1), homeodomain transcription factors, histones, and lamin A...
  16. ncbi Functional analysis of O-linked oligosaccharides in threonine/serine-rich region of Aspergillus glucoamylase by expression in mannosyltransferase-disruptants of yeast
    M Goto
    Laboratory of Applied Microbiology, Departemnt of Agricultural Chemistry, Kyushu University, Hakozaki, Fukuoka, Japan
    Eur J Biochem 260:596-602. 1999
    ..The number of O-linked mannose in GAI from wt yeast strain ranged in size from one (Man1) to five (Man5)...
  17. doi Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane
    Emilie Kondé
    Laboratoire de Biologie Structurale et Radiobiologie, URA CNRS 2096, CEA Saclay, 91190 Gif sur Yvette, France
    Biochemistry 49:8020-32. 2010
    b>MAN1, an integral protein of the inner nuclear membrane, influences transforming growth factor-β (TGF-β) signaling by directly interacting with R-Smads...
  18. pmc Intergenerational transmission of the behavioral consequences of early experience in prairie voles
    Anita Iyengar Stone
    Department of Psychology, University of California, Davis, CA 95616, USA
    Behav Processes 84:732-8. 2010
    ..were assigned to either a MAN0 "zero handling" manipulation (transfer with a cup during weekly cage changes) or a MAN1 "gloved handling" manipulation (transfer with a gloved hand). Previous studies from our laboratory (Bales et al...
  19. pmc Inferring the geometry of fourth-period metallic elements in arabidopsis thaliana seeds using synchrotron-based multi-angle X-ray fluorescence mapping
    Lester Young
    Agriculture and Agri Food Canada, 107 Science Place, Saskatoon, SK, Canada S7N 0X2
    Ann Bot 100:1357-65. 2007
    ..When mapping metal distribution in three dimensions, the time required to collect the data can become a major constraint. In this article a compromise is suggested between two- and three-dimensional mapping using multi-angle XRF imaging...
  20. pmc Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly
    Matyas Gorjanacz
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 26:132-43. 2007
    ..BAF interacts with LEM (LAP2, emerin, MAN1) domain-carrying proteins of the inner nuclear membrane...
  21. ncbi LEM-Domain proteins: new insights into lamin-interacting proteins
    Nicole Wagner
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Int Rev Cytol 261:1-46. 2007
    ..proteins present a growing family of nonrelated inner nuclear membrane and intranuclear proteins, including emerin, MAN1, LEM2, several alternatively spliced isoforms of LAP2, and various uncharacterized proteins in higher eukaryotes as ..
  22. ncbi LEMD3: the gene responsible for bone density disorders (osteopoikilosis)
    Edna Ben-Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Isr Med Assoc J 7:273-4. 2005
  23. ncbi N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system
    One Choi
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Glycobiology 13:539-48. 2003
    ..8% of total N-glycans) were elucidated. The glycan analysis revealed that the most abundant glycans were Man1-3(+/-Fucalpha6)GlcNAc2 (75.5%) and GlcNAcMan3(+/-Fucalpha6)GlcNAc2 (7.4%)...
  24. pmc Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina
    Ayelet Margalit
    Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 102:3290-5. 2005
    ..Caenorhabditis elegans BAF requires Ce-lamin and two LEM-domain proteins (Ce-emerin and Ce-MAN1) to localize during nuclear assembly...
  25. ncbi Nuclear envelopathies--raising the nuclear veil
    Raz Somech
    Sheba Cancer Research Center, Institute of Hematology, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Israel
    Pediatr Res 57:8R-15R. 2005
    ..To date, mutations in the genes encoding the nuclear envelope proteins emerin, MAN1, lamin A/C, and lamin B receptor were found to cause nuclear envelopathies...
  26. ncbi Distinct functions of the unique C terminus of LAP2alpha in cell proliferation and nuclear assembly
    Sylvia Vlcek
    Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Biol Chem 277:18898-907. 2002
    ..LAP2alpha contains a LEM (LAP2, emerin, and MAN1) domain in the constant N terminus that binds to chromosomal barrier-to-autointegration factor, and a C-terminal ..
  27. doi Essential roles of LEM-domain protein MAN1 during organogenesis in Xenopus laevis and overlapping functions of emerin
    Michael Reil
    Division of Electron Microscopy, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany Electronic address
    Eur J Cell Biol 92:280-94. 2013
    ..Conversely, mutations in nuclear envelope protein MAN1 are linked to bone and skin disorders. Both proteins share a highly conserved domain, called LEM-domain...
  28. doi Nuclear division: giving daughters their fair share
    Alison D Walters
    The Laboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD 20892, USA Electronic address
    Curr Biol 23:R1045-7. 2013
    ..daughter nuclei during mitosis? In Schizosaccharomyces japonicus, the conserved LEM-domain nuclear envelope protein Man1 ensures the formation of identical daughter nuclei by coupling nuclear pore complexes to the segregating ..
  29. ncbi The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans
    Yosef Gruenbaum
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Cell Sci 115:923-9. 2002
    ..We further show that four other types of nuclear envelope proteins, including fellow LEM-domain protein Ce-MAN1, as well as Ce-lamin, UNC-84 and nucleoporins do not depend on Ce-emerin for their localization...
  30. ncbi Inner nuclear membrane proteins: functions and targeting
    L Holmer
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Mol Life Sci 58:1741-7. 2001
    ..the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin...
  31. pmc Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:4028-38. 2013
    ..These findings identify several novel, candidate prognostic markers for NSCLC in never smokers, with eQTL analysis suggesting a potential biologic mechanism for a subset of these observed associations...
  32. doi Highlighting nuclear membrane staining in thyroid neoplasms with emerin: review and diagnostic utility
    Mary D Kinsella
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, USA
    Diagn Cytopathol 41:497-504. 2013
    Immunohistochemical staining (IHC) with emerin, an integral inner nuclear membrane protein, highlights nuclear membrane details in papillary thyroid carcinoma (PTC)...
  33. ncbi Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex
    Ben J Mans
    National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 3:1612-37. 2004
    ..that several central components of the NPC, in particular, the RanGDP import factor NTF2, the HEH domain of Src1p-Man1, and, probably, also the key domains of karyopherins and nucleoporins, the HEAT/ARM and WD40 repeats, have a ..
  34. ncbi A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development
    Ayelet Margalit
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Novartis Found Symp 264:231-40; discussion 240-5. 2005
    The C. elegans genome encodes a single lamin protein (Ce-lamin), three LEM domain proteins (Ce-emerin, Ce-MAN1 and LEM-3) and a single BAF protein (Ce-BAF). Down-regulation of Ce-lamin causes embryonic lethality...
  35. ncbi NMR assignment of region 655-775 of human MAN1
    Sandrine Caputo
    Departement d Ingenierie et d Etudes des Proteines, CEA Saclay, 91191, Gif sur Yvette, France
    J Biomol NMR 36:2. 2006
  36. ncbi [Buschke-Ollendorff syndrome: inactivating mutation of the LEMD3 gene]
    O Dereure
    Service de Dermatologie, Hopital Saint Eloi, Montpellier
    Ann Dermatol Venereol 132:593. 2005
  37. ncbi Fate of the nuclear lamina during Caenorhabditis elegans apoptosis
    Yonatan B Tzur
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    J Struct Biol 137:146-53. 2002
    ..TUNEL labeling indicated that Ce-lamin was degraded only after DNA is fragmented. Ce-lamin, Ce-emerin, or Ce-MAN1 were not cleaved by recombinant CED-3, showing that these lamina proteins are not substrates for CED-3 cleavage...
  38. doi Enzymatic hydrolysis of spent coffee ground
    T Jooste
    Department of Process Engineering, Stellenbosch University, Private Bag X1, Stellenbosch, 7602, South Africa
    Appl Biochem Biotechnol 169:2248-62. 2013
    ..The recombinant mannanase (Man1) provided the highest increments in soluble solids yield (17 %), even when compared with commercial preparations at ..
  39. ncbi Structural and topological studies on the lipid-mediated assembly of a membrane-associated lipomannan in Micrococcus luteus
    Leroy S Pakkiri
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Glycobiology 14:73-81. 2004
    ..luteus are incubated with GDP-[3H]mannose (GDP-Man), [3H]mannosyl units are incorporated into Man1-2-DAG, mannosylphosphorylundecaprenol (Man-P-Undec) and the membrane-associated lipomannan...
  40. doi Partitioning and Remodeling of the Schizosaccharomyces japonicus Mitotic Nucleus Require Chromosome Tethers
    Candice Yam
    Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604, Singapore Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
    Curr Biol 23:2303-10. 2013
    ..japonicus, which breaks and reforms the NE during mitosis [1, 2], the evolutionary conserved LEM-domain protein Man1 promotes equal partitioning of the nuclear membrane, nucleolar remodeling, and efficient inheritance of the ..
  41. ncbi Evaluation of an endo-beta-mannanase produced by Streptomyces ipomoea CECT 3341 for the biobleaching of pine kraft pulps
    M D Montiel
    Departamento de Microbiologia y Parasitologia, Universidad de Alcala, Alcala de Henares, Madrid, Spain
    Appl Microbiol Biotechnol 58:67-72. 2002
    ..mannanase bands (Man) with high and low electrophoretic mobility on the second and seventh days of incubation (Man1, Man3) and three bands of high, medium and low mobility from the third to sixth days of growth (Man1, Man2, Man3)...
  42. pmc GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL)
    Morten F Gjerstorff
    Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark
    PLoS ONE 7:e45819. 2012
    ..GCL directly binds LEM-domain proteins (LAP2β, emerin, MAN1) at the nuclear envelope, and we found that GAGE proteins were recruited to the nuclear envelope inner membrane by ..
  43. ncbi Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel)
    Nicole Wagner
    Division of Electron Microscopy, Biocenter of the University of Wurzburg, Wurzburg, Germany
    Eur J Cell Biol 82:605-16. 2004
    ..non-related proteins of the inner nuclear membrane including the lamina-associated polypeptides 2 (LAP2), emerin, MAN1 and the Drosophila protein otefin...
  44. ncbi The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe
    Babett Steglich
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
    Nucleus 3:77-87. 2012
    ..methyltransferase identification (DamID) to map the target loci of two inner nuclear membrane proteins, Ima1 and Man1. We found that peripheral chromatin shows low levels of RNA-Polymerase II and nucleosome occupancy, both ..
  45. doi The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo
    Andreas Brachner
    Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9, A 1030, Vienna, Austria
    J Cell Sci 125:1048-57. 2012
    The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration ..
  46. pmc Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, CA 92037, USA
    J Cell Biol 186:183-91. 2009
    ..In this study, we show that inner nuclear membrane proteins such as lamin B receptor (LBR), MAN1, Lap2beta, and the trans-membrane nucleoporins Ndc1 and POM121 drive the spreading of ER membranes into the ..
  47. doi Evolvement of LEM proteins as chromatin tethers at the nuclear periphery
    Andreas Brachner
    Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9, Vienna, Austria
    Biochem Soc Trans 39:1735-41. 2011
    ..LEM [LAP2 (lamina-associated polypeptide 2)/emerin/MAN1] domain-containing proteins of the inner nuclear membrane are involved in tethering chromatin to the nuclear ..
  48. doi Heterologous expression and optimized production of an Aspergillus aculeatus endo-1,4-beta-mannanase in Yarrowia lipolytica
    Robyn Roth
    CSIR Biosciences, Council of Scientific and Industrial Research, Pretoria 0001, South Africa
    Mol Biotechnol 43:112-20. 2009
    The Aspergillus aculeatus MRC11624 man1 gene, encoding an endo-beta-1,4-mannanase, was cloned and expressed in the promising heterologous enzyme producer, the ascomycetous yeast Yarrowia lipolytica...
  49. doi LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome
    Caroline Gaudy-Marqueste
    Service de Dermatologie, Hopital Ste Marguerite, Marseille, France
    J Med Genet 47:361-70. 2010
    ..this context, a search was undertaken for mutations in LMNA, encoding Lamins A/C, and ZMPSTE24, LBR, LMNB1, LMNB2, MAN1, SYNE1a and LAP2, encoding Lamins A/C molecular partners, in a Caucasian woman affected with Reynolds syndrome, a ..
  50. doi An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells
    Charlotta Buch
    Department of Biosciences and Nutrition, Karolinska Institute, SE 141 57 Huddinge, Sweden
    J Cell Sci 122:2100-7. 2009
    ..Interestingly, another integral inner nuclear membrane protein, emerin, was absent from the spindle-associated membranes...
  51. doi The 12q14 microdeletion syndrome: additional patients and further evidence that HMGA2 is an important genetic determinant for human height
    Karen Buysse
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Med Genet 52:101-7. 2009
    ....
  52. doi Production of the Aspergillus aculeatus endo-1,4-beta-mannanase in A. niger
    Petrus J van Zyl
    CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
    J Ind Microbiol Biotechnol 36:611-7. 2009
    The beta-mannanase gene (man1) from Aspergillus aculeatus MRC11624 (Izuka) was patented for application in the coffee industry. For production of the enzyme, the gene was originally cloned and expressed in Saccharomyces cerevisiae...
  53. pmc Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosis
    Francesca Mari
    Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Eur J Hum Genet 17:1141-7. 2009
    ..Such cases will likely be diagnosed as Silver-Russell-like or as primordial dwarfism...
  54. doi Cell-surface display of the active mannanase in Yarrowia lipolytica with a novel surface-display system
    Xiao Song Yang
    College of Life Science, Hubei University, Wuhan 430062, People s Republic of China
    Biotechnol Appl Biochem 54:171-6. 2009
    ..system was constructed using the cell-wall anchor protein Flo1p from Saccharomyces cerevisiae, the mannanase (man1) from Bacillus subtilis fused with the C-terminus of Flo1p and the 6xHis tag was inserted between Flo1p and man1...
  55. doi Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions
    Chi Hui Liang
    The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan
    Anal Chem 81:7750-6. 2009
    ..Well-defined recognition systems, namely, mannose derivatives (Man1, Man4, and Man9) with a mannose binding lectin (Concanavalin A) and a stage-specific embryonic antigens-3 (SSEA-3) ..
  56. pmc Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation
    Michael D Huber
    Department of Cell Biology, IMM 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 29:5718-28. 2009
    ..The nuclear envelope transmembrane protein NET25 (Lem2) is a truncated paralog of MAN1, an NE component linked to bone disorders...
  57. doi Buschke-Ollendorff syndrome with striking phenotypic variation resulting from a novel c.2203C>T nonsense mutation in LEMD3
    Manuela Yuste-Chaves
    Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain
    Pediatr Dermatol 28:447-50. 2011
    ..The mutation induces a change in the 735 arginine codon to a stop codon. This study shows the wide phenotypic variation in BOS and increases the repertory of mutations described to date in LEMD3...
  58. doi Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin expression
    Bettina Burger
    Department of Dermatology, University Hospital Basel, Hebelstr 20, 4031 Switzerland
    Eur J Dermatol 20:693-7. 2010
    ....
  59. doi Laminopathies and lamin-associated signaling pathways
    Nadir M Maraldi
    Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy
    J Cell Biochem 112:979-92. 2011
    ..Lamin-binding proteins implicated in laminopathies include lamin B2, nuclear envelope proteins such as emerin, MAN1, LBR, and nesprins, the nuclear matrix protein matrin 3, the lamina-associated polypeptide, LAP2alpha and the ..
  60. pmc The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth
    Sally Ann Lynch
    National Centre for Medical Genetics, Our Lady s Childrens Hospital, Dublin, Ireland
    Eur J Hum Genet 19:534-9. 2011
    ..Four cases had moderate delay, two had severe developmental delay and a further two had a diagnosis of autism. All six cases had significant speech delay with subtle facial dysmorphism...
  61. ncbi [Karyoskeletal and nuclear envelope proteins in cell cycle progression--known proteins in new functions]
    Magda Dubińska-Magiera
    Pracownia Białek Jadrowych, Wydział Biotechnologii, Uniwersytet Wrocławski, Wrocław
    Postepy Biochem 56:362-72. 2010
    ..Nuclear envelope, which is composed of integral membrane proteins of the INM (LAP1, LAP2, emerin, MAN1, LBR), has many functions including: connection of nucleoskeleton with cytoskeleton, nuclear lamina meshwork and ..
  62. pmc Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling
    Adam J Meyer
    Department of Genome Dynamics, University of California, Berkeley, CA 94720, USA
    J Cell Sci 124:1433-44. 2011
    ..The nuclear envelope protein MAN1, nuclear pore proteins Tpr and Nup62, and nucleoplasmic proteins NuMA and LAP2α also have aberrant distributions, ..
  63. doi Buschke-Ollendorff syndrome: absence of LEMD3 mutation in an affected family
    Michelle Yadegari
    Division of Dermatology, Department of Medicine, Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY 10467, USA
    Arch Dermatol 146:63-8. 2010
    ..Heterozygous, loss-of-function, germline mutation in the LEMD3 gene (which encodes an inner nuclear membrane protein called LEMD3, or MAN1) has been repeatedly documented in patients with BOS or OPK.
  64. doi The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins
    Nicole Wagner
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Dev Biol 339:1-13. 2010
    ..Here, we show that the nuclear LEM-domain protein MAN1 is a tissue-specific antagonist of BMP signaling in Drosophila. MAN1 contains two potential Mad-binding sites...
  65. doi The heterozygous Lemd3 +/GT mouse is not a murine model for osteopoikilosis in humans
    Annelies Dheedene
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Calcif Tissue Int 85:546-51. 2009
    ..Also, histological analysis did not reveal lesions typical for osteopoikilosis. We conclude that the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome...
  66. pmc Is the 6 kDa tobacco etch viral protein a bona fide ERES marker?
    Alexander Lerich
    Department of Plant Cell Biology, Centre for Organismal Studies, University of Heidelberg, Germany
    J Exp Bot 62:5013-23. 2011
    ..this integral membrane protein co-localizes with both the COPII coat protein YFP-SEC24 and the Golgi marker Man1-RFP...
  67. doi Submicroscopic chromosomal imbalances in idiopathic Silver-Russell syndrome (SRS): the SRS phenotype overlaps with the 12q14 microdeletion syndrome
    S Spengler
    Institute of Human Genetics, University Hospital, RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    J Med Genet 47:356-60. 2010
    ..Thus, molecular karyotyping is indicated in SRS and should be included in the diagnostic algorithm...
  68. pmc No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA
    Ying Huang
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25123. 2011
    ..We find that, contrary to previous reports, BAF does not interact with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C...
  69. doi Cell cycle-dependent phosphorylation of MAN1
    Yasuhiro Hirano
    Graduate School of Biostudies, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochemistry 48:1636-43. 2009
    The LEM (LAP2beta, Emerin, and MAN1) proteins are essential for nuclear membrane targeting to chromatin via an association with barrier-to-autointegration factor (BAF)...
  70. pmc The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression
    Stefanie E Grund
    Biochemie Zentrum der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 182:897-910. 2008
    ..a robust genetic interaction between transcription export (TREX) factors and yeast Src1, an integral inner nuclear membrane protein that is homologous to vertebrate LEM2...
  71. pmc Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein
    Belinda S Pinto
    Molecular and Cellular Biology Program, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
    Genetics 180:133-45. 2008
    ..One family of lamina proteins is defined by an approximately 40-aa LAP2, Emerin, and MAN1 (LEM) domain (LEM-D) that binds the nonspecific DNA-binding protein, barrier-to-autointegration factor (BAF)...
  72. ncbi Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells
    Takeshi Shimi
    CREST of JST, Kansai Advanced Research Center, CRL, Kobe 651 2492, Japan
    J Struct Biol 147:31-41. 2004
    ..BAF interacts with LEM-domain proteins including emerin, LAP2 beta, and MAN1 in the inner nuclear membrane...
  73. pmc MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans
    Jun Liu
    Department of Molecular Biology and Genetics, 439 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 100:4598-603. 2003
    Emerin and MAN1 are LEM domain-containing integral membrane proteins of the vertebrate nuclear envelope...
  74. ncbi SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1
    G Praveen Raju
    Cell and Molecular Biology Graduate Group, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:428-37. 2003
    ..Antagonistic Effector), a novel protein with significant sequence similarity to nuclear envelop proteins such as MAN1. SANE binds to Smad1/5 and to BMP type I receptors and regulates BMP signaling...
  75. pmc FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis
    Elizabeth E Rogers
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Plant Cell 14:1787-99. 2002
    ..frd3-3 was first identified as man1. The FRD3 gene is expressed at detectable levels in roots but not in shoots and is predicted to encode a membrane ..
  76. pmc Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly
    Miriam Segura-Totten
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 158:475-85. 2002
    ..BAF binds directly to LEM (LAP2, emerin, MAN1) domain nuclear membrane proteins, including LAP2 and emerin...
  77. pmc Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans
    Kenneth K Lee
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 13:892-901. 2002
    ..The envelope localization of Ce-lamin, Ce-emerin, Ce-MAN1, and nucleoporins are unaffected by the loss of UNC-84...
  78. ncbi Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane
    Wei Wu
    Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Cell Sci 115:1361-71. 2002
    b>MAN1 is an integral protein of the inner nuclear membrane that shares the LEM domain, a conserved globular domain of approximately 40 amino acids, with lamina-associated polypeptide (LAP) 2 and emerin...
  79. pmc Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    M Cai
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0510, USA
    EMBO J 20:4399-407. 2001
    The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved approximately 40-residue 'LEM' motif. Loss of emerin causes Emery-Dreifuss muscular dystrophy...
  80. ncbi Structural characterization of the LEM motif common to three human inner nuclear membrane proteins
    C Laguri
    Departement d Ingenierie et d Etudes des Proteines, CEA Saclay, 91191, Gif sur Yvette, France
    Structure 9:503-11. 2001
    ..A common structural domain of 50 residues, called the LEM domain, has been identified in emerin MAN1, and lamina-associated polypeptide (LAP) 2...
  81. ncbi Identification of N- and O-linked oligosaccharides in human seminal vesicles
    M I Arenas
    Department of Cell Biology and Genetics, University of Alcala, Alcalé de Henares, Madrid, Spain
    J Androl 22:79-87. 2001
    ..SNA), Neu5Acalphaa2,3Galbeta1,4GlcNAc (MAA), Galbeta1,4GlcNAc (DSA), branched mannose chains (ConA), Man1,3Man (GNA), and Fucalpha1,2Galbeta1,4GlcNAcFucalpha1,3GlcNAc (LTA) but reaction to these residues was weak (MAA, ..
  82. pmc C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis
    K K Lee
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 11:3089-99. 2000
    Emerin, MAN1, and LAP2 are integral membrane proteins of the vertebrate nuclear envelope. They share a 43-residue N-terminal motif termed the LEM domain...
  83. ncbi Free N-glycans already occur at an early stage of seed development
    Y Kimura
    Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Okayama 700 8530, Japan
    J Biochem 127:1013-9. 2000
    ..detailed structural analysis revealed that the high-mannose type structures have a common core unit; Manalpha1-6(Man1-3)Manalpha1-6(Manalpha1-3)Ma nbeta1-4GlcNAc...
  84. ncbi MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin
    F Lin
    Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:4840-7. 2000
    ..We now show that one of the human MAN antigens termed MAN1 is a 82...
  85. pmc A metal-accumulator mutant of Arabidopsis thaliana
    E Delhaize
    Division of Plant Industry, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australia
    Plant Physiol 111:849-55. 1996
    A mutation designated man1 (for manganese accumulator) was found to cause Arabidopsis thaliana seedlings to accumulate a range of metals. The man1 mutation segregated as a single recessive locus located on chromosome 3...
  86. ncbi Expression cloning, purification and characterization of a beta-1,4-mannanase from Aspergillus aculeatus
    S Christgau
    GeneExpress, Novo Nordisk A S, Copenhagen, Denmark
    Biochem Mol Biol Int 33:917-25. 1994
    ..All clones represented transcripts of the same mannanase gene (man1)...
  87. ncbi Synthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Man2GlcNAc2 and Man1GlcNAc2 are transferred from dolichol to protein in vivo
    B J Jackson
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Arch Biochem Biophys 272:203-9. 1989
    ..The alg2/pAC3 cells are viable at 36 degrees C. Two isomers of Man2GlcNAc2, Man1----3ManGlcNAc2 and Man1----6ManGlcNAc2, were present on lipid and protein...
  88. ncbi Autoantigens of the nuclear pore complex
    P Enarson
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Calgary, 3330 Hospital Dr N W, Calgary, AB, T2N 4N1, Canada
    J Mol Med (Berl) 82:423-33. 2004
    ..the lamins A, B, and C of the nuclear lamina, gp210, p62 complex proteins, Nup153, and Tpr within the NPC, and LBR, MAN1, LAP1, and LAP2 that are integral proteins of the INM...
  89. ncbi LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Thomas Dechat
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
    J Cell Sci 117:6117-28. 2004
    Lamina-associated polypeptide (LAP) 2alpha is a LEM (lamina-associated polypeptide emerin MAN1) family protein associated with nucleoplasmic A-type lamins and chromatin...
  90. ncbi MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling
    Feng Lin
    Department of Medicine and Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 14:437-45. 2005
    b>MAN1 (also known as LEMD3) is an integral protein of the inner nuclear membrane. Recently, mutations in MAN1 have been shown to result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis...
  91. doi Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner
    Akihiko Ishimura
    The 21st Century Center of Excellence COE Program, Akita University, Akita, Japan
    Dev Dyn 237:3565-76. 2008
    b>Man1, an inner nuclear membrane protein, regulates transforming growth factor beta signaling by interacting with receptor-associated Smads...
  92. ncbi Gene silencing at the nuclear periphery
    Sigal Shaklai
    Sheba Cancer Research Center and the Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    FEBS J 274:1383-92. 2007
    ..Emerin and another INM protein, MAN1, have been linked to down-regulation of specific signaling pathways, the retino blastoma 1/E2F MyoD and ..
  93. ncbi What MAN1 does to the Smads. TGFbeta/BMP signaling and the nuclear envelope
    Luiza Bengtsson
    Institute for Chemistry and Biochemistry, Free University Berlin, Thielallee 63, 14195 Berlin, Germany
    FEBS J 274:1374-82. 2007
    The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGFbeta/BMP) signaling...
  94. ncbi Early experience affects the traits of monogamy in a sexually dimorphic manner
    Karen L Bales
    Department of Psychology, University of California, Davis 95616, USA
    Dev Psychobiol 49:335-42. 2007
    ..were either transferred between cages in a cup (zero manipulation, MAN0) or with a gloved hand (one manipulation, MAN1). Following weaning the offspring were tested for alloparental behavior...
  95. ncbi Familial cutaneous collagenomas resulting from a novel mutation in LEMD3
    D Hershkovitz
    Laboratory of Molecular Dermatology and Department of Dermatology, Rambam Health Care Campus, Haifa, Israel
    Br J Dermatol 156:375-7. 2007
  96. pmc Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins
    Antoine Muchir
    Departments of Medicine and Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biochem Biophys Res Commun 351:1011-7. 2006
    ....
  97. ncbi Deactivating germline mutations in LEMD3 cause osteopoikilosis and Buschke-Ollendorff syndrome, but not sporadic melorheostosis
    Steven Mumm
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 22:243-50. 2007
    ..Others, finding deactivating germline LEMD3 mutations in OPK or BOS, concluded such defects explain all three conditions. We found germline LEMD3 mutations in OPK and BOS but not in sporadic MEL...
  98. ncbi Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling
    Akihiko Ishimura
    The 21st Century Center of Excellence Program, Akita University School of Medicine, Hondo 1 1 1, Akita, Japan
    Development 133:3919-28. 2006
    ..b>Man1, an INM protein, has recently been shown to regulate transforming growth factor (Tgf) beta superfamily signaling by ..
  99. ncbi Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1
    Rocio Montes De Oca
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 280:42252-62. 2005
    ..BAF binds directly to LEM domain nuclear proteins (e.g. LAP2, Emerin, and MAN1), lamin A, homeodomain transcription factors, and human immunodeficiency virus type 1-encoded proteins...
  100. pmc Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins
    Cecilia Ostlund
    Department of Medicine, College of Physicians and Surgeons, Columbia University, Room 10 509, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 45:1374-82. 2006
    ..Emerin, MAN1, and LBR are three integral inner nuclear membrane proteins...
  101. ncbi Inner nuclear membrane and regulation of Smad-mediated signaling
    Howard J Worman
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, 10th Floor, Room 508, New York, NY 10032, USA
    Biochim Biophys Acta 1761:626-31. 2006
    ..b>MAN1, an integral protein of the inner nuclear membrane, binds to receptor-regulated Smads and antagonizes signaling by ..

Research Grants59

  1. Functional Analysis of LEM-domain Nuclear Proteins
    Katherine Wilson; Fiscal Year: 2005
    ..We propose to determine the essential function of three conserved LEM proteins in C.elegans: emerin, MAN1 and lem-3. In C...
  2. Regulation of TGFbeta superfamily signaling by MAN1
    Luis Estevez; Fiscal Year: 2007
    ..We have recently shown that the inner nuclear membrane protein MAN1 can repress TGF-beta, BMP and activin signaling through its interaction with the Smad proteins...
  3. Roles of BAF-Like in the nucleus
    Miriam Segura Totten; Fiscal Year: 2005
    ..BAF-L interacts with BAF, a conserved chromatin protein important for nuclear assembly, and with LAP2beta and MAN1, two membrane-anchored members of the LEM-domain family of nuclear proteins...
  4. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  5. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2007
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  6. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 2003
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  7. Genetic Instability & Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2009
    ..The ability to identify high-risk subgroups of individuals for EAC will provide immense public health benefit for those high-risk people who may be subjected to close surveillance and chemoprevention. ..
  8. Genetic Instability & Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2010
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  9. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  10. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2007
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  11. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  12. Lamin A Mutation and Hutchinson-Gilford Progeria
    Howard Worman; Fiscal Year: 2007
    ..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
  13. Nucleocytoplasmic Interactions and Dynamics in Emery-Dreifuss Muscular Dystrophy
    Howard Worman; Fiscal Year: 2009
    ....
  14. Neurobiological Mechanisms of Social Bonding in a Monogamous Primate
    Karen Bales; Fiscal Year: 2009
    ..This is relevant to the study of disorders of social bonding such as autism. ..
  15. Pathogenesis of Emery-Dreifuss Muscular Dystrophy
    Howard Worman; Fiscal Year: 2009
    ....
  16. Neurobiological Mechanisms of Social Bonding in a Monogamous Primate
    Karen L Bales; Fiscal Year: 2010
    ..This is relevant to the study of disorders of social bonding such as autism. ..
  17. Nucleocytoplasmic Interactions and Dynamics in Emery-Dreifuss Muscular Dystrophy
    Howard J Worman; Fiscal Year: 2010
    ....
  18. Pathogenesis of Emery-Dreifuss Muscular Dystrophy
    Howard J Worman; Fiscal Year: 2010
    ....
  19. Nucleocytoplasmic Interactions and Dynamics in Emery-Dreifuss Muscular Dystrophy
    Howard Worman; Fiscal Year: 2009
    ....
  20. Pathogenesis of Emery-Dreifuss Muscular Dystrophy
    Howard J Worman; Fiscal Year: 2010
    ....
  21. Lamin A in Adipocyte Differentation and Survival
    Howard Worman; Fiscal Year: 2004
    ..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..
  22. Pathogenesis of Emery-Dreifuss Muscular Dystrophy
    Howard Worman; Fiscal Year: 2007
    ..This work will help establish how abnormalities in the nuclear envelope cause muscular dystrophy. ..
  23. DUX4 and Facioscapulohumeral Muscular Dystrophy
    Howard Worman; Fiscal Year: 2004
    ..This work could lead to the development of new diagnostic methods as well as the identification of potential protein targets for the treatment of FSHD. ..
  24. Pathogenesis of Emery-Dreifuss Muscular Dystrophy
    Howard J Worman; Fiscal Year: 2010
    ..The results obtained in this project will identify targets for therapeutic interventions in EDMD and related disorders caused by LMNA and EMD mutations. ..