MAGED1

Summary

Gene Symbol: MAGED1
Description: MAGE family member D1
Alias: DLXIN-1, NRAGE, melanoma-associated antigen D1, MAGE tumor antigen CCF, MAGE-D1 antigen, melanoma antigen family D, 1, melanoma antigen family D1, neurotrophin receptor-interacting MAGE homolog
Species: human
Products:     MAGED1

Top Publications

  1. Bertrand M, Huijbers I, Chomez P, De Backer O. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. Dev Dyn. 2004;230:325-34 pubmed
    The MAGED gene subfamily contains three genes in mouse and four in human. The MAGED1, D2, and D3 proteins are highly conserved between mouse and human, whereas paralogues are less conserved between each other...
  2. Reddy E, Chettiar S, Kaur N, Ganeshkumar R, Shepal V, Shanbhag N, et al. Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells. Cancer Gene Ther. 2011;18:206-18 pubmed publisher
    ..These two attributes, in conjunction, result in conversion of the drug-resistant brain tumor stem cells to the tumor-attenuated cells that may now be more amenable to effective therapeutic targeting. ..
  3. Di Certo M, Corbi N, Bruno T, Iezzi S, De Nicola F, Desantis A, et al. NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. J Cell Sci. 2007;120:1852-8 pubmed
    Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development...
  4. Wen C, Xue B, Qin W, Yu M, Zhang M, Zhao D, et al. hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. FEBS Lett. 2004;564:171-6 pubmed
    ..Moreover, the cell cycle inhibiting protein p21(WAF) is induced by hNRAGE in a p53 dependent manner. The data provide original evidence that hNRAGE arrests cell growth through a p53 dependent pathway. ..
  5. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem. 2002;277:22541-6 pubmed
    ..These results suggest that Praja1 regulates the transcription function of the homeodomain protein Dlx5 by controlling the stability of Dlxin-1 via an ubiquitin-dependent degradation pathway. ..
  6. Jordan B, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death. J Biol Chem. 2001;276:39985-9 pubmed
    ..the search for novel IAP-interacting proteins we identified the neurotrophin receptor-interacting MAGE homologue (NRAGE) as being able to bind to the avian IAP homologue ITA. This interaction requires the RING domain of ITA...
  7. Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K. Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001;276:5331-8 pubmed
    ..Transfection and reporter gene assays indicate that Dlxin-1 activates the transcriptional function of Dlx5. Therefore, Dlxin-1 may act as a regulator of the function of Dlx family members in bone formation. ..
  8. Tian X, Rai D, Li J, Zou C, Bai Y, Wazer D, et al. BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Cancer Res. 2005;65:4747-53 pubmed
  9. Snezhkina A, Lukyanova E, Zaretsky A, Kalinin D, Pokrovsky A, Golovyuk A, et al. Novel potential causative genes in carotid paragangliomas. BMC Med Genet. 2019;20:48 pubmed publisher
    ..a total of 16 candidate genes (MYH15, CSP1, MYH3, PTGES3L, CSGALNACT2, NMD3, IFI44, GMCL1, LSP1, PPFIBP2, RBL2, MAGED1, CNIH3, STRA6, SLC6A13, and ATM) whose variants potentially influence their expression (cis-effect)...

More Information

Publications55

  1. Xu Z, Zhou C, Zhang K, Zheng Y. Identification of key genes in Ankylosing spondylitis. Immunol Lett. 2018;204:60-66 pubmed publisher
    ..BIRC2, MAPILC3A and MAGED1 were hub proteins...
  2. Jiang X, Jiang X, Yang Z. NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer. Gene. 2018;: pubmed publisher
    Neurotrophin receptor-interacting melanoma antigen-encoding protein (NRAGE) is a type II melanoma-associated antigen that plays an essential role in various processes, including cell differentiation and apoptosis...
  3. Zeinieh M, Salehi A, Rajkumar V, Barker P. p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade. J Cell Sci. 2015;128:447-59 pubmed
    ..We show that the p75NTR adaptor protein NRAGE (also known as MAGED1) acts downstream of the p75NTRICD in this cascade and, through a yeast two-hybrid screen, identify NEDD9, a Cas ..
  4. Wang Q, Tang J, Jiang S, Huang Z, Song A, Hou S, et al. Inhibition of PPAR?, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol. 2018;: pubmed publisher
    ..MAGE family member D1 (MAGED1), by acting as an adaptor for ubiquitin-dependent degradation pathways and a co-factor for transcription, plays an ..
  5. Qi S, Wu Q, Ma J, Li J, Chen F, Xu Y, et al. Effects of neurotrophin receptor-mediated MAGE homology on proliferation and odontoblastic differentiation of mouse dental pulp cells. Cell Prolif. 2015;48:221-30 pubmed publisher
    This study aimed to investigate effects of neurotrophin receptor-mediated melanoma antigen-encoding gene homology (NRAGE) on proliferation and odontoblastic differentiation of mouse dental pulp cells (mDPCs)...
  6. De Backer J, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, et al. Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine. EMBO Rep. 2018;19: pubmed publisher
    ..Here, we describe an unexpected role for one of these genes, Maged1, in the control of behaviours related to drug addiction...
  7. Guha I, Slamova I, Chun S, Clegg A, Golos M, Thrasivoulou C, et al. The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons. Neurobiol Aging. 2016;46:138-48 pubmed publisher
    ..Conversely, proNGF neurotoxicity was JNK-dependent and mediated by the p75-interacting protein NRAGE, whereas neurite outgrowth was independent of NRAGE...
  8. Liu M, Xu L, Ma X, Xu J, Wang J, Xian M, et al. MAGED1 is a negative regulator of bone remodeling in mice. Am J Pathol. 2015;185:2653-67 pubmed publisher
    b>Melanoma antigen family D1 (MAGED1), an important adaptor protein, has been shown to ubiquitously express and play critical roles in many aspects of cellular events and physiological functions...
  9. De Donato M, Peters S, Hussain T, Rodulfo H, Thomas B, Babar M, et al. Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades. Mamm Genome. 2017;28:443-454 pubmed publisher
    ..Type II genes can be divided into two: those with 13 exons (MAGED1, MAGED2, TRO, and MAGED4) and those with only one exon (MAGEE1, MAGEE2, MAGEF1, NSMCE3, MAGEH1, MAGEL2, and NDN) ..
  10. Kanda M, Shimizu D, Fujii T, Tanaka H, Tanaka Y, Ezaka K, et al. Neurotrophin Receptor-Interacting Melanoma Antigen-Encoding Gene Homolog is Associated with Malignant Phenotype of Gastric Cancer. Ann Surg Oncol. 2016;23:532-539 pubmed
    ..Neurotrophin receptor-interacting melanoma antigen-encoding protein (NRAGE) regulates apoptosis and metastasis via interactions with various genes...
  11. Zhang G, Zhou H, Xue X. Complex roles of NRAGE on tumor. Tumour Biol. 2016;37:11535-11540 pubmed
    b>NRAGE, also known as Dlxin-1or MAGE-D1, is a member of type II melanoma-associated antigen (MAGE) and plays an essential role in life activities, including differentiation, apoptosis, and cell cycle...
  12. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), melanoma antigen gene family member D1 (MAGED1), membrane spanning 4-domains A7 (MS4A7), hephaestin like 1 (HEPHL1), BH3 (Bcl-2 homology 3)-like motif containing,..
  13. Shen W, Xue Q, Zhu J, Hu B, Zhang Y, Wu Y, et al. Inhibition of adenovirus-mediated human MAGE-D1 on angiogenesis in vitro and in vivo. Mol Cell Biochem. 2007;300:89-99 pubmed
  14. Salehi A, Roux P, Kubu C, Zeindler C, Bhakar A, Tannis L, et al. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron. 2000;27:279-88 pubmed
    ..were used to identify proteins involved in p75NTR apoptotic signaling, and a p75NTR binding partner termed NRAGE (for neurotrophin receptor-interacting MAGE homolog) was identified...
  15. Teixeira F, Randle S, Patel S, Mevissen T, Zenkeviciute G, Koide T, et al. Gsk3? and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Biochem J. 2016;473:3563-3580 pubmed
    ..degradation, and c-IAP1 (inhibitor of apoptosis protein 1), TNF receptor-associated factor 2 (TRAF2), and NRAGE, which are not destabilized as a result of ubiquitination...
  16. Zhou H, Zhang G, Xue X, Yang Y, Yang Y, Chang X, et al. Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells. Tumour Biol. 2016;37:8741-52 pubmed publisher
    ..The previous results of gene microarray and subsequent verification showed that NRAGE might be involved in radiation resistance of ESCC cells...
  17. Zhou Y, Huang N, Wu J, Zhen N, Li N, Li Y, et al. Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells. Tumour Biol. 2017;39:1010428317709676 pubmed publisher
    b>NRAGE has been reported to be overexpressed in cancer cells, especially in lung cancer cells...
  18. Mouri A, Noda Y, Watanabe K, Nabeshima T. The roles of MAGE-D1 in the neuronal functions and pathology of the central nervous system. Rev Neurosci. 2013;24:61-70 pubmed publisher
  19. Zeng Z, Wu W, Yang J, Tang Z, Chen D, Qiu M, et al. Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. J Transl Med. 2012;10:181 pubmed publisher
    Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family...
  20. Matsuda T, Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, et al. The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution. J Biol Chem. 2003;278:29057-64 pubmed
    ..Thus, Ror2 sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Msx2. ..
  21. Zhang C, Xing G, Wei H, Yu Y, He F. [A new melanoma antigen-encoding gene subfamily in human chromosome X]. Yi Chuan Xue Bao. 2001;28:197-203 pubmed
    ..The identification of MAGE-D subfamily will be helpful in understanding the genesis of tumor. ..
  22. Bronfman F, Tcherpakov M, Jovin T, Fainzilber M. Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J Neurosci. 2003;23:3209-20 pubmed
    ..Finally, NGF induced endosomal association of p75 and its MAGE interactors, necdin and NRAGE. These data suggest that signaling endosomes containing activated p75 are involved in neurotrophin signaling, and ..
  23. Shen W, Xue Q, Wu Y, Hu B, Zhu J, Zhang Y, et al. Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress. Cell Commun Adhes. 2007;14:21-31 pubmed
    ..These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression. ..
  24. Chu C, Xue B, Tu C, Feng Z, Shi Y, Miao Y, et al. NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo. Cancer Lett. 2007;250:268-75 pubmed
    We previously reported that human NRAGE could significantly alter the cellular skeleton and inhibit cell-cell adhesion, suggesting that human NRGAE play a potential role in cellular motility...
  25. Chen Y, Jin L, Xue B, Jin D, Sun F, Wen C. NRAGE induces ?-catenin/Arm O-GlcNAcylation and negatively regulates Wnt signaling. Biochem Biophys Res Commun. 2017;487:433-437 pubmed publisher
    ..In this study, we report that human NRAGE, a neurotrophin receptor p75 (p75NTR) binding protein, markedly suppresses the expression of genes activated by ..
  26. Grau C, Starkovich M, Azamian M, Xia F, Cheung S, Evans P, et al. Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability. PLoS ONE. 2017;12:e0175962 pubmed publisher
    ..and two protein coding genes-the G1 to S phase transition 2 gene (GSPT2) and the MAGE family member D1 gene (MAGED1). Deletions of this ~430 kb region have not been previously implicated in human disease...
  27. Kofler M, Motzny K, Beyermann M, Freund C. Novel interaction partners of the CD2BP2-GYF domain. J Biol Chem. 2005;280:33397-402 pubmed
    ..A direct interaction of the CD2BP2-GYF domain with the novel protein interaction partners PI31 and NPWBP was verified by yeast two-hybrid analysis. ..
  28. Sullivan A, Peet D, Whitelaw M. MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS J. 2016;283:3488-502 pubmed publisher
    ..This study identifies and characterises a novel interaction between melanoma-associated antigen D1 (MAGED1) and select members of the bHLH PAS transcription factor family...
  29. Zhou L, Xue B, Guo S, Shi Y, Wen C, Li C. [Construction of recombinant adenovirus vector of hNRAGE gene and its effect on cell cycle of 293 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006;22:18-21 pubmed
    ..hNRAGE gene can inhibit the growth of 293 cells. ..
  30. Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, et al. Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic Acids Res. 2017;45:10595-10613 pubmed publisher
    ..dependent, unforeseen function of the nuclear isoform of the Receptor for Advanced Glycation End-products (nRAGE) in DSB-repair...
  31. Xu Y, Wu R, Gu Y, Yang Y, Yang M, Nwariaku F, et al. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem. 2002;277:28051-7 pubmed
    ..We speculate that endothelial cells may target endogenous oxidant production to specific sites critical to cytokine signaling as a mechanism for increasing signal specificity and decreasing toxicity of these reactive species. ..
  32. Yang Q, Ou C, Liu M, Xiao W, Wen C, Sun F. NRAGE promotes cell proliferation by stabilizing PCNA in a ubiquitin-proteasome pathway in esophageal carcinomas. Carcinogenesis. 2014;35:1643-51 pubmed publisher
    Neurotrophin receptor-interacting melanoma antigen-encoding gene homolog (NRAGE) is generally recognized as a tumor suppressor as it induces cell apoptosis and suppresses cell metastasis...
  33. Doyle J, Gao J, Wang J, Yang M, Potts P. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010;39:963-74 pubmed publisher
    ..For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family. ..
  34. Williams M, Strickland P, Watanabe K, Hinck L. UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. J Biol Chem. 2003;278:17483-90 pubmed
    ..Here, we report an interaction between UNC5H1 and NRAGE. Our experiments show that this interaction is responsible for apoptosis induced by UNC5H1, and this level of ..
  35. Kubu C, Goldhawk D, Barker P, Verdi J. Identification of the translational initiation codon in human MAGED1. Genomics. 2000;70:150-2 pubmed
  36. Xue X, Liu Z, Jing F, Li Y, Liu H, Gao X. Relationship between NRAGE and the radioresistance of esophageal carcinoma cell line TE13R120. Chin J Cancer. 2010;29:900-6 pubmed
    ..cell line TE13R120 as compared with its parental cell line TE13 before and after radiation, and the expression of NRAGE gene showed a gradually up-regulating tendency...
  37. Pold M, Zhou J, Chen G, Hall J, Vescio R, Berenson J. Identification of a new, unorthodox member of the MAGE gene family. Genomics. 1999;59:161-7 pubmed
    ..We have identified a novel member of the MAGE gene family, MAGED1. Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult ..
  38. Yang Q, Pan Q, Li C, Xu Y, Wen C, Sun F. NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis. Cell Death Differ. 2016;23:1406-16 pubmed publisher
    b>NRAGE, a neurotrophin receptor-interacting melanoma antigen-encoding gene homolog, is significantly increased in the nucleus of radioresistant esophageal tumor cell lines and is highly upregulated to promote cell proliferation in ..
  39. Gudmundsson J, Sulem P, Rafnar T, Bergthorsson J, Manolescu A, Gudbjartsson D, et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008;40:281-3 pubmed publisher
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease. ..
  40. Kang J, Chung K. The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE). Cell Mol Life Sci. 2015;72:181-95 pubmed publisher
    ..two-hybrid screen of a human fetal brain library and identified neurotrophin receptor-interacting MAGE protein (NRAGE) as a novel FBXO7-binding partner...
  41. Matluk N, Rochira J, Karaczyn A, Adams T, Verdi J. A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010;8:7 pubmed publisher
    ..Its effect on NF-kappaB has yet to be explored. Herein we report that NRAGE, via the same XIAP-Tak1-Tab1 complex, is required for the phosphorylation of IKK -alpha/beta and subsequent ..
  42. Agrawal P, Chen Y, Schilling B, Gibson B, Hughes R. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012;287:21164-75 pubmed publisher
    ..Taken together, our data describe the identification of the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. ..
  43. Xue B, Wen C, Shi Y, Zhao D, Li C. Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion. Biochem Biophys Res Commun. 2005;336:247-51 pubmed
    Human NRAGE, a neurotrophin receptor p75 interaction MAGE homologue, confers NGF-dependent apoptosis of neuronal cells by inducing caspase activation through the JNK-c-jun-dependent pathway and arrests cell growth through the p53-..
  44. Kendall S, Goldhawk D, Kubu C, Barker P, Verdi J. Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis. Mech Dev. 2002;117:187-200 pubmed
    Neurotrophin receptor-interacting MAGE (NRAGE) is the most recently identified p75 neurotrophin receptor (p75(NTR)) intracellular binding protein...
  45. Stone B, Schummer M, Paley P, Crawford M, Ford M, Urban N, et al. MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. Gene. 2001;267:173-82 pubmed
    ..Furthermore, potential cross-reactivity to these ubiquitously expressed MAGE gene products should be considered in the design of MAGE-targeted immunotherapies for cancer. ..
  46. Du Q, Zhang Y, Tian X, Li Y, Fang W. MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells. Oncol Rep. 2009;22:659-65 pubmed
    MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins...