MAFK

Summary

Gene Symbol: MAFK
Description: MAF bZIP transcription factor K
Alias: NFE2U, P18, transcription factor MafK, basic-leucine zipper transcription factor MafK, erythroid transcription factor NF-E2 p18 subunit, nuclear factor erythroid-2, ubiquitous (p18), v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K, v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
Species: human
Products:     MAFK

Top Publications

  1. Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996;16:6083-95 pubmed
    Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors...
  2. Nguyen T, Huang H, Pickett C. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem. 2000;275:15466-73 pubmed
    ..In this study, using in vitro binding assays, Nrf2/MafK heterodimers were found to interact with high affinity to the ARE...
  3. Dhakshinamoorthy S, Jaiswal A. Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. J Biol Chem. 2000;275:40134-41 pubmed
    ..In this study, we demonstrate that overexpression of small Maf (MafG and MafK) proteins negatively regulate ARE-mediated expression and tert-butyl hydroquinone induction of the NQO1 and GST Ya ..
  4. Liu G, Qu J, Shen X. NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta. 2008;1783:713-27 pubmed publisher
    ..histone deacetylase 3 (HDAC3), the corepressor, to ARE by facilitating the interaction of HDAC3 with either CBP or MafK, leading to local histone hypoacetylation...
  5. Nammo T, Udagawa H, Funahashi N, Kawaguchi M, Uebanso T, Hiramoto M, et al. Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice. Diabetologia. 2018;61:2608-2620 pubmed publisher
    ..whereas decreased H3K27ac was enriched for v-maf musculoaponeurotic fibrosarcoma oncogene family protein K (MAFK), a known negative regulator of beta cells...
  6. Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher
    ..membrane protein 2C; LAMP1: lysosomal associated membrane protein 1; MAFF: MAF bZIP transcription factor F; MAFK: MAF bZIP transcription factor K; NFE2L2/NRF2: nuclear factor, erythroid derived 2, like 2; NQO1: NAD(P)H quinone ..
  7. Madhu Krishna B, Chaudhary S, Mishra D, Naik S, Suklabaidya S, Adhya A, et al. Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer. BMC Cancer. 2018;18:607 pubmed publisher
    ..ERα directly targets ERRβ through estrogen response element and ERRβ also mediates cell cycle regulation through p18, p21cip and cyclin D1 in breast cancer cells...
  8. Weidner C, Rousseau M, Plauth A, Wowro S, Fischer C, Abdel Aziz H, et al. Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species. Phytomedicine. 2015;22:262-70 pubmed publisher
    ..cyclin dependent kinases (CDK) 2, 4, 6, cyclin D3, and induced expression of cyclin-dependent kinase inhibitor 2C (p18) and 1A (p21). LBE (600 µg/ml) induced cleavage of caspases 3 and 7 and phosphatidylserine externalization...
  9. Abaza M, Orabi K, Al Quattan E, Al Attiyah R. Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. Cancer Cell Int. 2015;15:46 pubmed publisher
    ..and cell-cycle regulatory genes by down-regulating Cdk4, Cdk6, Cdk7, Bcl2, x-IAP and c-IAP-2 and up-regulating p18, p19, p21, caspases 3, 7, 8 and 9, Bak, AIF and Bax in both colorectal and breast cancer cells...

More Information

Publications117 found, 100 shown here

  1. Karrasch M, Herfurth K, Kläver M, Miethke J, Mayer Scholl A, Luge E, et al. Severe leptospirosis complicated by Epstein-Barr Virus reactivation. Infection. 2015;43:763-9 pubmed publisher
    ..interrogans of different serovars. EBV IgA immunoblot taken at admission was positive for VCA-p18, quantitative EBV-PCR showed an EBV viral load of 2.8E3 copies/ml indicating acute EBV-reactivation...
  2. Tan L, Liao Y, Fan J, Zhang Y, Mao X, Sun Y, et al. Prediction and identification of novel IBV S1 protein derived CTL epitopes in chicken. Vaccine. 2016;34:380-6 pubmed publisher
    ..Poly-CTL-epitope DNA vaccine (pV-S1T) was constructed by inserting nucleotide sequences encoding the P8, P9, P18, and P19 CTL epitopes into the pVAX1 vector...
  3. Pietraszek Gremplewicz K, Kozakowska M, Bronisz Budzynska I, Ciesla M, Mucha O, Podkalicka P, et al. Heme oxygenase-1 influences satellite cells and progression of Duchenne muscular dystrophy in mice. Antioxid Redox Signal. 2018;: pubmed publisher
    ..RNA sequencing revealed downregulation of Atf3, MafK, Foxo1 and Klf2 transcription factors, known to activate Hmox1 expression, as well as attenuation of nitric oxide-..
  4. Berridge G, Menassa D, Moloney T, Waters P, Welding I, Thomsen S, et al. Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome. Neurology. 2018;91:e714-e723 pubmed publisher
    ..similar immunoreactivities were used in immunoprecipitation experiments using cerebellum from postnatal rat pups (P18)...
  5. Kim M, Kim H, Kim D, Park C, Huh Y, Jung J, et al. Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves. Materials (Basel). 2019;12: pubmed publisher
    ..AIMPs, which are well known as nonenzymatic factors, include AIMP1/p43, AIMP2/p38, and AIMP3/p18. The canonical functions of AIMPs include not only protein synthesis via multisynthetase complexes but also ..
  6. Liang D, Halpert M, Konduri V, Decker W. Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity. Int Rev Immunol. 2015;34:367-81 pubmed publisher
    ..Together with other nonenzymatic mARS structural components AIMp2/38 and AIMp3/p18, it participates in the machinery responsible for cell-cycle control and tumor suppression...
  7. Bamodu O, Kuo K, Yuan L, Cheng W, Lee W, Ho Y, et al. HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of hsa-miR-196a targeting BCR/ABL1. Exp Cell Res. 2018;370:519-530 pubmed publisher
    ..correlates with enhanced expression of HDACs 1-6, cyclins D1/D3, CDK 2, 4 and 6, while inversely correlating with p18, p21 and p27...
  8. Zhang Z, Leir S, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015;52:387-96 pubmed publisher
    ..leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) heterodimers...
  9. LoPresti P. Inducible Expression of a Truncated Form of Tau in Oligodendrocytes Elicits Gait Abnormalities and a Decrease in Myelin: Implications for Selective CNS Degenerative Diseases. Neurochem Res. 2015;40:2188-99 pubmed publisher
    ..with both EGFP-∆Tau and Cre manifested an overt phenotype of loss of balance and stumbles starting around p18. CNS tissues obtained from TM-treated EGFP-∆Tau/Cre double transgenic mice had recombined PCR products, GFP, ..
  10. Taniguchi H, Okamuro S, Koji M, Waku T, Kubo K, Hatanaka A, et al. Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes. Biochem Biophys Res Commun. 2017;484:176-183 pubmed publisher
    ..gene expression of the deubiquitinating enzymes (DUBs) but not proteasome subunits in Nrf1 NKO mice between P7 and P18. First, we show that K48-linked polyubiquitinated proteins accumulate in Nrf1-deficient Purkinje cells and cerebral ..
  11. Zhao Y, Zheng D, Cvekl A. A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells. Exp Eye Res. 2018;175:56-72 pubmed publisher
    ..g. E2Fs, Etv5, Hsf4, c-Maf, MafG, MafK, N-Myc, and Pax6) transcription factors and a number of novel regulators of lens formation, such as Arntl2, Dmrta2, ..
  12. Sukhanova I, Sebentsova E, Khukhareva D, Manchenko D, Glazova N, Vishnyakova P, et al. Gender-dependent changes in physical development, BDNF content and GSH redox system in a model of acute neonatal hypoxia in rats. Behav Brain Res. 2018;350:87-98 pubmed publisher
    ..but not male pups demonstrated less weight gain than control littermates for the entire observation period (until P18)...
  13. Djouadi L, Selama O, Abderrahmani A, Bouanane Darenfed A, Abdellaziz L, Amziane M, et al. Multiresistant opportunistic pathogenic bacteria isolated from polluted rivers and first detection of nontuberculous mycobacteria in the Algerian aquatic environment. J Water Health. 2017;15:566-579 pubmed publisher
    ..Citrobacter freundii strain P18 showed a high molecular weight plasmid which seems to code for resistance to zinc, lead, and tetracycline, at the ..
  14. Tsang S, Chan L, Tsai Y, Wu W, Hsu C, Yang J, et al. Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis). Trans Am Ophthalmol Soc. 2014;112:103-15 pubmed
    ..The mutant Pde6b(H620Q)/Pde6b(H620Q) at P14 and P18 photoreceptor outer segment (OS) lysates were labeled with P-ATP and hybridized to an array of 1,164 different ..
  15. Weiss E, Osawa S, Xiong Y, Dhungana S, Carlson J, McRitchie S, et al. Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa. Exp Eye Res. 2019;: pubmed publisher
    ..Mice raised entirely in the dark until P18 were also evaluated...
  16. Chang M, Shieh D, Chen C, Yeh C, Dong H. Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs. Int J Mol Sci. 2015;16:28169-79 pubmed publisher
    ..Furthermore, by using genechip analysis, we observed that linalool can promote p53, p21, p27, p16, and p18 gene expression...
  17. Yoshida M, Hiroi M, Imai T, Kikumori T, Himeno T, Nakamura Y, et al. A case of ACTH-independent macronodular adrenal hyperplasia associated with multiple endocrine neoplasia type 1. Endocr J. 2011;58:269-77 pubmed
    ..Genetic abnormalities in the MEN1, p27, and p18 genes were not found, however, the present case may provide a clue to the understanding of the etiology of MEN1 and ..
  18. Shiheido Y, Maejima Y, Suzuki J, Aoyama N, Kaneko M, Watanabe R, et al. Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. J Mol Cell Cardiol. 2016;99:123-137 pubmed publisher
    ..g. invaded the ischemic myocardium of the P.g.-inoculated MI mice. The expression of p18 Bax, an active form of pro-apoptotic Bax protein, markedly increased in the P.g.-inoculated MI hearts...
  19. Martínez Fernández de la Cámara C, Hernández Pinto A, Olivares González L, Cuevas Martín C, Sánchez Aragó M, Hervás D, et al. Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration. Sci Rep. 2015;5:11764 pubmed publisher
    ..In our housing conditions, rd10 retinas were seriously damaged at P18. Adalimumab reduced photoreceptor cell death, as determined by scoring the number of TUNEL-positive cells...
  20. Sun J, Guo Y, Fu X, Wang Y, Liu Y, Huo B, et al. Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2/M phase and regulating key biomarkers. Onco Targets Ther. 2016;9:21-30 pubmed publisher
    ..IGFBP2, IGFBP4, and GATA3 were significantly decreased, and the messenger RNA and protein levels of ELF5, p53, p21, p18, CDH1, CDH2, and p12 were significantly increased, compared to the control group (P<0.05)...
  21. Kotake Y, Goto T, Naemura M, Inoue Y, Okamoto H, Tahara K. Long Noncoding RNA PANDA Positively Regulates Proliferation of Osteosarcoma Cells. Anticancer Res. 2017;37:81-85 pubmed
    ..Quantitative RT-PCR showed that silencing PANDA increased mRNA levels of the cyclin-dependent kinase inhibitor p18, which caused G1 phase arrest...
  22. Li J, Li Y, Meng F, Fu L, Kong C. Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing Wnt/β-catenin signaling pathway. Biosci Rep. 2018;38: pubmed publisher
    ..Linc00511 knockdown could cause the cell proliferation suppression and cell cycle arrest, which were mediated by p18, p21, CDK4, cyclin D1 and phosphorylation Rb...
  23. Ma D, Guo D, Li W, Zhao H. Mdig, a lung cancer-associated gene, regulates cell cycle progression through p27(KIP1). Tumour Biol. 2015;36:6909-17 pubmed publisher
    ..in A549 cells transfected with mdig siRNA to examine the expression levels of the cell cycle related genes such as p18(INK4c), p19(INK4d), p21(WAF/CIP1), p27(KIP1), p57(KIP2), cyclin D1, and cyclin E...
  24. Ogolla S, Daud I, Asito A, Sumba O, Ouma C, Vulule J, et al. Reduced Transplacental Transfer of a Subset of Epstein-Barr Virus-Specific Antibodies to Neonates of Mothers Infected with Plasmodium falciparum Malaria during Pregnancy. Clin Vaccine Immunol. 2015;22:1197-205 pubmed publisher
    ..In utero malaria exposure resulted in significant reductions in transplacental transfer of anti-VCA-p18 and anti-EBNA1 antibodies of 13% and 22%, respectively...
  25. Nagesh P, Hatami E, Chowdhury P, Kashyap V, Khan S, Hafeez B, et al. Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer. Cancers (Basel). 2018;10: pubmed publisher
    ..Tannic acid exhibited elevated G₁ population, due to increase in p18INK4C and p21WAF1/CIP1 expression, while cyclin D1 expression was inhibited...
  26. Marx S. Hyperparathyroid genes: sequences reveal answers and questions. Endocr Pract. 2011;17 Suppl 3:18-27 pubmed publisher
    ..type 1-like families were shown to have inactivating germline mutations, first of p27 and subsequently of p15, p18, or p21...
  27. Mohammadi Yeganeh S, Vasei M, Tavakoli R, Kia V, Paryan M. The effect of miR-340 over-expression on cell-cycle-related genes in triple-negative breast cancer cells. Eur J Cancer Care (Engl). 2017;26: pubmed publisher
    ..genes including cyclin A2 (cyclin A2), Cyclin-dependent kinases 2 (CDK2), cyclin-dependent kinase inhibitors (P16, P18 and P27), Retinoblastoma (RB) and transcription factors (SMAD 4, SOX2 and SOX17) was investigated using ..
  28. Serra N, Velte E, Niedenberger B, Kirsanov O, Geyer C. Cell-autonomous requirement for mammalian target of rapamycin (Mtor) in spermatogonial proliferation and differentiation in the mouse†. Biol Reprod. 2017;96:816-828 pubmed publisher
    ..MTOR germ cell KO mice were viable and healthy, but testes from neonatal (postnatal day (P)8), juvenile (P18), and adult (P > 60) KO mice were smaller than littermate controls, and no sperm were produced in adult testes...
  29. Costa Guda J, Soong C, Parekh V, Agarwal S, Arnold A. Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas. Horm Cancer. 2013;4:301-7 pubmed publisher
    ..the other six CDKI genes CDKN1A, CDKN1C, CDKN2A, CDKN2B, CDKN2C, and CDKN2D, encoding p21, p57, p14(ARF)/p16, p15, p18, and p19, respectively, contribute to the development of typical parathyroid adenomas...
  30. Yuan J, Jiang Y, Mayakonda A, Huang M, Ding L, Lin H, et al. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017;77:6614-6626 pubmed publisher
    ..DNA-binding motif analysis within the SE segments suggest that several transcription factors (including ETS2, MAFK, and TEAD1) may help establish and maintain SE activity across the genome...
  31. Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, et al. RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma. Oncogene. 2016;35:5000-9 pubmed publisher
    ..Knockdown of RBM47 also enhanced the expression of some Nrf2 activators, p21/CDKN1A and MafK induced by TGF-β...
  32. Pautassi R, Nizhnikov M, Truxell E, Varlinskaya E, Spear N. Ontogeny of ethanol intake in alcohol preferring (P) and alcohol nonpreferring (NP) rats. Dev Psychobiol. 2011;53:234-45 pubmed publisher
    ..This heightened ethanol preference transiently reversed at P8, reemerged as weaning approached (P18) and was fully expressed during adolescence...
  33. Dai M, Lu J, Guo W, Yu W, Wang Q, Tang R, et al. BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas. Oncotarget. 2015;6:33878-92 pubmed publisher
    ..BPTF knockdown by siRNA also upregulated the cell cycle inhibitors such as p21 and p18 but inhibited the expression of cyclin D, phospho-Rb and phospho-cdc2 in lung cancer cells...
  34. Cheng P, Wang Y, Li G, Yang S, Liu C, Hu H, et al. Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway. Cancer Lett. 2016;370:136-44 pubmed publisher
    ..Menin overexpression significantly activated the expression of the cyclin-dependent kinase (CDK) inhibitors p18 and p27, accompanied with a decrease in DNA methylation levels of p18 and p27 promoters...
  35. Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
    ..The novel endosome protein, p18, enhances vascular endothelial (VE)-cadherin recycling from early endosome to cell junction to improve pulmonary ..
  36. Bichsel K, Hammiller B, Trempus C, Li Y, Hansen L. The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse. Exp Dermatol. 2016;25:275-81 pubmed publisher
    ..in the nuclei of control follicular keratinocytes at P16 then rapidly decreased until it was undetectable between P18 and 21. In contrast, Rcc2 expression continued in Egfr mutant follicles throughout this period...
  37. Gataullina S, Lemaire E, Wendling F, Kaminska A, Watrin F, Riquet A, et al. Epilepsy in young Tsc1(+/-) mice exhibits age-dependent expression that mimics that of human tuberous sclerosis complex. Epilepsia. 2016;57:648-59 pubmed publisher
    ..by fast activity repeated every 2-10 s for at least 20 s, accompanied by rhythmic limb contractions; from P14 to P18 a "tonic-clonic like" pattern comprised rhythmic spikes of increasing amplitude with tonic-clonic movements...
  38. Tian Y, Che F, Su Q, Lu Y, You C, Huang L, et al. Effects of mutant TDP-43 on the Nrf2/ARE pathway and protein expression of MafK and JDP2 in NSC-34 cells. Genet Mol Res. 2017;16: pubmed publisher
    ..We further showed that expression of the MafK protein and the Jun dimerization protein 2 (JDP2) was reduced in TDP-43-M337V plasmid-transfected NSC-34 cells, ..
  39. Wang X, Wu J, Jian S, Yang G, Hu B, Wen C. Microcystin induction small Maf protein involve in transcriptional regulation of GST from freshwater mussel Cristaria plicata. Gene. 2018;660:51-61 pubmed publisher
    The small Mafs, MafF, MafG and MafK play critical roles in morphogenesis and homeostasis through associating with Cap "n" Collar family of transcription factors...
  40. Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, et al. Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018;: pubmed publisher
    ..Here, we report on a human APOB peptide, p18, that is sequence-identical in mouse ApoB and binds to both mouse and human MHC-II...
  41. Nishida Y, Pachulska Wieczorek K, BÅ‚aszczyk L, Saha A, Gumna J, Garfinkel D, et al. Ty1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions. Nucleic Acids Res. 2015;43:7414-31 pubmed publisher
    ..A subgenomic Ty1 mRNA encodes a truncated Gag protein (p22) that is cleaved by Ty1 protease to form p18. p22/p18 strongly inhibits transposition and can be considered an element-encoded restriction factor...
  42. Matsumoto M, Kondo K, Shiraki T, Brydun A, Funayama R, Nakayama K, et al. Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis. Genes Cells. 2016;21:553-67 pubmed publisher
    ..than its known functions, we carried out a genomewide mapping of binding site for BACH1 and its heterodimer partner MAFK in immortalized MEFs (iMEFs) using chromatin immunoprecipitation and next-generation sequencing technology (ChIP-..
  43. Nuzzo A, Giuffrida D, Masturzo B, Mele P, Piccoli E, Eva C, et al. Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise. Cell Cycle. 2017;16:200-212 pubmed publisher
    ..Preeclamptic (PE) placentae presented differences in the expression of G1/S-phase regulators p16INK4A, p18INK4C, CDK4 and CDK6...
  44. Liu H, Jiang F, Jia X, Lan J, Guo H, Li E, et al. Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7. Oncotarget. 2017;8:10298-10311 pubmed publisher
    ..CLDN7 acted as a bridge to promote HIF1a-induced P18 expression and cell differentiation...
  45. Williams L, Niemeyer B, Franklin D, Clambey E, van Dyk L. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency. J Virol. 2015;89:10821-31 pubmed publisher
    ..Here, we tested the genetic requirement for the viral cyclin in mice that lack the host inhibitors p27(Kip1) and p18(INK4c), two cyclin-dependent kinase inhibitors known to be important in regulating B cell proliferation and ..
  46. Kapadia F, Bub K, Barton S, Stults C, Halkitis P. Longitudinal Trends in Sexual Behaviors Without a Condom Among Sexual Minority Youth: The P18 Cohort Study. AIDS Behav. 2015;19:2152-61 pubmed publisher
  47. Jeyanathan J, Escobar M, Wallace R, Fievez V, Vlaeminck B. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. BMC Microbiol. 2016;16:104 pubmed publisher
    ..of the well-known rumen biohydrogenating bacteria, Butyrivibrio fibrisolvens D1 and Butyrivibrio proteoclasticus P18, to hydrogenate 22:6n-3. Butyrivibrio fibrisolvens D1 failed to hydrogenate 22:6n-3 (0...
  48. Storholm E, Satre D, Kapadia F, Halkitis P. Depression, Compulsive Sexual Behavior, and Sexual Risk-Taking Among Urban Young Gay and Bisexual Men: The P18 Cohort Study. Arch Sex Behav. 2016;45:1431-41 pubmed publisher
    ..and combined influence on sexual risk-taking behavior among a diverse sample of YMSM in New York City (the P18 Cohort Study)...
  49. Abdellatif A, Oishi H, Itagaki T, Jung Y, Shawki H, Okita Y, et al. β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS ONE. 2016;11:e0150010 pubmed publisher
    ..b>MAFK is a member of the small MAF family and acts as a dominant negative form of large MAFs...
  50. Ferro Cavalcante T, Marcelino da Silva A, Amaral Almeida L, Tavares G, de Farias Campina R, do Nascimento E, et al. Effects of perinatal protein malnutrition and fenfluramine action on food intake and neuronal activation in the hypothalamus and raphe nuclei of neonate rats. Physiol Behav. 2016;165:35-42 pubmed publisher
    ..this study examined the serotonin-system's impact on food intake in rat neonates at postnatal day (P) 10 and P18 and the manner in which protein undernutrition during pregnancy and lactation interferes in this behavior...
  51. Chatterjee R, Gupta S, Law S. Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimental myelodysplasia. Chem Biol Interact. 2017;273:1-10 pubmed publisher
    ..along with the expressional study of cleaved caspase-3, PCNA, Chk-2, p53, Ndn, Gfi-1, Tie-2, Sdf-1, Gsk-3?, p18 and Myt-1 in the bone marrow compartment...
  52. Joksovic P, Lunardi N, Jevtovic Todorovic V, Todorovic S. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015;52:952-8 pubmed publisher
    ..from intact neurons of the nucleus reticularis thalami (nRT) in brain slices from rat pups (postnatal age P10-P18) exposed at age of P7 to clinically relevant GA combinations of Iso and N2O...
  53. Lucas S, Armstrong D. Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus. Neuropharmacology. 2015;99:232-41 pubmed publisher
    ..we performed perforated patch-clamp recordings from CA1 pyramidal neurones in acute brain slices from P14-P18 mice...
  54. Tomita S, Kikuti Y, Carreras J, Kojima M, Ando K, Takasaki H, et al. Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. Mod Pathol. 2015;28:1286-96 pubmed publisher
    ..3 (CKS1B), 6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using formalin-fixed paraffin-embedded sections...
  55. Siconolfi D, Kapadia F, Moeller R, Eddy J, Kupprat S, Kingdon M, et al. Body Dissatisfaction in a Diverse Sample of Young Men Who Have Sex With Men: The P18 Cohort Study. Arch Sex Behav. 2016;45:1227-39 pubmed publisher
    ..The findings point to future avenues of research, particularly qualitative research to explore demographic and cultural nuances in body attitudes among YMSM. ..
  56. Alonso I, Baroja A, Fernández B, Vielba R, Elorriaga J, Pérez Sanz J, et al. Changes in the expression of cyclin dependent kinase inhibitors during differentiation of immortalized fibroblasts into adipocytes. Int J Dev Biol. 2017;61:89-93 pubmed publisher
    ..Maximal levels of p16INK4A were detected following 48 h of differentiation treatment. Highest levels of p18INK4C were measured during the phase of cell confluence prior to treatment and in differentiated cells...
  57. Tan L, Bahmed K, Lin C, Marchetti N, Bolla S, Criner G, et al. The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema. Sci Rep. 2018;8:3555 pubmed publisher
    ..NFE2 is a heterodimer composed of two subunits, a 45 kDa (p45 NFE2) and 18 kDa (p18 NFE2) polypeptides. Low expression of p45 NFE2 in patients with emphysema correlated with a high ECM degradation...
  58. Robitaille K, Rourke J, McBane J, Fu A, Baird S, Du Q, et al. High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. J Biol Chem. 2016;291:4614-25 pubmed publisher
    ..for use in primary cells and demonstrate that silencing the cell cycle-dependent kinase inhibitors CDKN2C/p18 or CDKN1A/p21 facilitates cell cycle entry of quiescent adult human pancreatic beta cells...
  59. Stroobants S, Van Acker N, Verheijen F, Goris I, Daneels G, Schot R, et al. Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice. Exp Neurol. 2017;291:106-119 pubmed publisher
    ..stage (p0), microarray analysis revealed increased differential gene expression in later postnatal stages (p10-p18)...
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    ..We demonstrate that Sema3A strengthens and maintains CF synapses from postnatal day 8 (P8) to P18 and opposes the force of CF elimination...
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    ..inner ear organs were not so damaged to cause the hearing deficit of circling (cir/cir) mouse at 18 postnatal day (P18) though auditory brainstem response data indicated hearing loss of cir/cir mice at P18...
  62. Zhao C, Wu H, Qimuge N, Pang W, Li X, Chu G, et al. MAT2A promotes porcine adipogenesis by mediating H3K27me3 at Wnt10b locus and repressing Wnt/?-catenin signaling. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:132-142 pubmed publisher
    ..Additionally, MAT2A interacted with MafK protein and was recruited to MARE element at Wnt10b gene...
  63. Ney P, Andrews N, Jane S, Safer B, Purucker M, Weremowicz S, et al. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol. 1993;13:5604-12 pubmed
    ..Immunoprecipitation experiments demonstrated that p45 NF-E2 is associated in vivo with an 18-kDa protein (p18)...
  64. Johnsen O, Skammelsrud N, Luna L, Nishizawa M, Prydz H, Kolstø A. Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res. 1996;24:4289-97 pubmed
    ..These findings place TCF11 as a good candidate for the proposed widely expressed factor(s) known to interact with small Maf proteins and bind NF-E2 sites in a sequence-specific manner resembling NF-E2. ..
  65. Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, Murata M, et al. Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood. 2012;120:3812-21 pubmed publisher
    ..Among the tested factors, transfection with p45NF-E2/MafG/MafK lead to the highest frequency of CD41-positive cells...
  66. Zhou X, Chen S, Xie L, Ji Y, Wu X, Wang W, et al. Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin Mice. Int J Mol Sci. 2016;17:301 pubmed publisher
    ..and NIHL, we established a Cx26 knockdown (KD) mouse model by conditional knockdown of Cx26 at postnatal day 18 (P18), and then we observed the auditory threshold and morphologic changes in these mice with or without noise exposure...
  67. Anand D, Lachke S. Systems biology of lens development: A paradigm for disease gene discovery in the eye. Exp Eye Res. 2017;156:22-33 pubmed publisher
    ..Pou2f1), Meis1, Pnox1, Zeb2 (Sip1), Mab21l1, Foxe3, Tfap2a (Ap2-alpha), Pitx3, Sox11, Prox1, Sox1, c-Maf, Mafg, Mafk, Hsf4, Fgfrs, Bmp7, and Tdrd7 in this tissue...
  68. Garg S, Paiva I, Vakili M, Soudy R, Agopsowicz K, Soleimani A, et al. Traceable PEO-poly(ester) micelles for breast cancer targeting: The effect of core structure and targeting peptide on micellar tumor accumulation. Biomaterials. 2017;144:17-29 pubmed publisher
    ..The surface of both micelles was also modified with the breast cancer targeting peptide, P18-4...
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    ..We found that musculoaponeurotic fibrosarcoma (MAF) oncogene family protein K (MAFK), a member of the small MAF family of transcription factors that are induced by the TGF-? pathway, was abundant in ..
  71. Lin Y, Wang Y, Qiao S, An H, Wang J, Ma Y, et al. "In vivo self-assembled" nanoprobes for optimizing autophagy-mediated chemotherapy. Biomaterials. 2017;141:199-209 pubmed publisher
    ..The purpurin-18 (P18) monomer is connected to hydrophilic poly(amidoamine) dendrimer (4th generation) through a peptide (..
  72. Conemans E, Raicu Ionita G, Pieterman C, Dreijerink K, Dekkers O, Hermus A, et al. Expression of p27Kip1 and p18Ink4c in human multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. J Endocrinol Invest. 2018;41:655-661 pubmed publisher
    ..Several lines of evidence point towards a role for p27Kip1 and p18Ink4c in MEN1-related tumor development in animal models for MEN1, but their contribution to human MEN1-..
  73. Iwata T, Kogame K, Toki T, Yokoyama M, Yamamoto M, Ito E. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. Cytogenet Cell Genet. 1998;82:88-90 pubmed
    ..To facilitate understanding of the function of small Maf proteins, we isolated the genes (MAFG and MAFK) encoding human small Maf proteins MafG and MafK and characterized their structures and organization by means of ..
  74. Hwang Y, Lee E, Song J, Kim H, Jun Y, Hwang K. MafK positively regulates NF-?B activity by enhancing CBP-mediated p65 acetylation. Sci Rep. 2013;3:3242 pubmed publisher
    ..We identified MafK, a novel transcriptional regulator that modulates NF-?B activity...
  75. Cheng D, Qi G, Wang J, Cong Y, Liu F, Yu H, et al. In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates. Biomacromolecules. 2017;18:1249-1258 pubmed publisher
    ..Phenylboronic acid modified purpurin 18 (NPBA-P18) could attach onto the RGD-decorated dextran (RGD-Dex), and the resulting RGD-Dex/NPBA-P18 (RDNP) conjugates with ..
  76. Kobayashi A, Ito E, Toki T, Kogame K, Takahashi S, Igarashi K, et al. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999;274:6443-52 pubmed
    ..regions of erythroid-specific genes recognized by the erythroid transcription factor NF-E2, composed of p45 and MafK. Recently, two p45-related factors Nrf1 and Nrf2 were isolated, and they are now collectively grouped as the Cap'n' ..
  77. Ueda K, Xu J, Morimoto H, Kawabe A, Imaoka S. MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei. FEBS Lett. 2008;582:2357-64 pubmed publisher
    ..The knockdown of MafG did not change total HIF-1alpha protein, but reduced the accumulation of HIF-1alpha in the nuclei. These results suggest that MafG regulates the hypoxic response of cells by detaining HIF-1alpha in the nuclei. ..
  78. Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, et al. Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol. 2008;15:1246-54 pubmed publisher
    ..Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53. ..
  79. Avtanski D, Nagalingam A, Tomaszewski J, RISBOOD P, Difillippantonio M, Saxena N, et al. Indolo-pyrido-isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53-miR34a axis. Mol Oncol. 2016;10:1118-32 pubmed publisher
    ..compounds, 11-methoxy-2,3,4,13-tetrahydro-1H-indolo[2',3':3,4]pyrido[1,2-b]isoquinolin-6-ylium-bromide (termed P18 or NSC-768219) inhibits growth and clonogenic potential of cancer cells...
  80. van Tilborg E, Achterberg E, van Kammen C, van der Toorn A, Groenendaal F, Dijkhuizen R, et al. Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury. Glia. 2018;66:78-93 pubmed publisher
    ..and postnatal hypoxia resulted in delayed cortical myelination, microglia activation and astrogliosis at P18, together with long-term changes in oligodendrocyte maturation as observed in 10 week old animals...
  81. Jae Ik Lee -, Fried S, Maesoon Im -. Network-mediated responses of ON ganglion cells to electric stimulation become less consistent across trials during retinal degeneration. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2114-2117 pubmed publisher
    ..Here, we examined response variability at several different stages of degeneration: postnatal day 14 (P14), P18, P31 and P60 in a well-established mouse model of degeneration (rd10)...
  82. Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, et al. Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun. 2017;8:1625 pubmed publisher
    ..which are anchored to lysosomes via Ragulator, a pentameric protein complex consisting of membrane-anchored p18/LAMTOR1 and two roadblock heterodimers...
  83. Ochiai K, Katoh Y, Ikura T, Hoshikawa Y, Noda T, Karasuyama H, et al. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem. 2006;281:38226-34 pubmed
    ..The heterodimer of Bach2/MafK bound to the Maf recognition element located upstream of the Prdm1 promoter in an electrophoretic mobility shift ..
  84. Wang R, Zheng J, Zhang D, Yang Y, Zhao Z. Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation. Genet Mol Res. 2015;14:7315-25 pubmed publisher
    ..In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related ..
  85. Matsumoto T, Saito Y, Itokawa T, Shiba T, Oba M, Takahashi H, et al. Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model. Graefes Arch Clin Exp Ophthalmol. 2017;255:1981-1990 pubmed publisher
    ..Sixteen 50/10 OIR rats were compared with 17 control rats reared in room air. In postnatal day 14 (P14) and P18 rats, we measured and analyzed the left eye's mean blur rate (MBR) by setting a rubber band on the optic nerve head ..
  86. Zhang T, Wang R, Wang Z, Wang X, Wang F, Ding J. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun. 2017;8:1394 pubmed publisher
    ..1 (mTORC1) is mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive...
  87. Aguilar R, Casabonne D, O Callaghan Gordo C, Vidal M, Campo J, Mutalima N, et al. Assessment of the Combined Effect of Epstein-Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach. Front Immunol. 2017;8:1284 pubmed publisher
    ..activator protein (ZEBRA), early antigen-diffuse component (EA-D), EBV nuclear antigen 1, and viral capsid antigen p18 subunit (VCA-p18)] and 15 P...
  88. Halkitis P, Cook S, Ristuccia A, Despotoulis J, Levy M, Bates F, et al. Psychometric Analysis of the Life Worries Scale for a New Generation of Sexual Minority Men: The P18 Cohort Study. Health Psychol. 2017;: pubmed publisher
    ..However, there is limited psychometric research seeking to quantify the life worries of this population. Informed by syndemic theory, the Life Worries Scale (LWS) was developed to measure the concerns of young SMM...
  89. Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, et al. Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. J Biol Chem. 2018;293:1781-1793 pubmed publisher
    ..analysis of developing brains revealed that the switch from 3R to 4R tau occurred during postnatal day 9 (P9) to P18 under the same time course as the conversion of phosphorylation from high to low...
  90. Tham Y, Huynh K, Mellett N, Henstridge D, Kiriazis H, Ooi J, et al. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:219-234 pubmed publisher
    ..BA supplementation increased a major plasmalogen species (p18:0) in the heart but had no effect on heart size or function...
  91. Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, et al. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Oncogene. 1997;14:1901-10 pubmed
    ..characterization of NF-E2 functions in human cells, we isolated cDNAs encoding two members of the small Maf family, MafK and MafG...
  92. Wen T, Afroz S, Reinhard S, Palacios A, Tapia K, Binder D, et al. Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice. Cereb Cortex. 2017;:1-14 pubmed publisher
    ..Second, MMP-9 levels were elevated in P12-P18 auditory cortex of Fmr1 KO mice and genetic reduction of MMP-9 to WT levels restored the formation of PNNs around ..