MAFB

Summary

Gene Symbol: MAFB
Description: MAF bZIP transcription factor B
Alias: DURS3, KRML, MCTO, transcription factor MafB, Kreisler maf-related leucine zipper homolog, MAFB/Kreisler basic region/leucine zipper transcription factor, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
Species: human
Products:     MAFB

Top Publications

  1. Sieweke M, Tekotte H, Frampton J, Graf T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell. 1996;85:49-60 pubmed
    Using a yeast one-hybrid screen with a DNA-bound Ets-1 protein, we have identified MafB, an AP-1 like protein, as a direct interaction partner...
  2. Wang P, Eisenbart J, Cordes S, Barsh G, Stoffel M, Le Beau M. Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics. 1999;59:275-81 pubmed
    ..The KRML (MAFB) transcriptional regulator plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ..
  3. Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, et al. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. Cell Death Differ. 2006;13:1686-96 pubmed
    ..Although MafB transcription factor is believed to play a role in the regulation of monocytic commitment, no demonstration is, to ..
  4. Cordes S, Barsh G. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell. 1994;79:1025-34 pubmed
    ..The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development. ..
  5. Van Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers H, Bast B. Identification of primary MAFB target genes in multiple myeloma. Exp Hematol. 2009;37:78-86 pubmed publisher
    ..One of the partner loci maps to 20q12 and involves the MAFB gene resulting in its ectopic expression. We attempt here to identify MAFB target genes in MM...
  6. Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, et al. Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling. PLoS ONE. 2014;9:e113610 pubmed publisher
    ..while apoptosis was induced in areas of GST-P(+) foci of Valerian groups associated with suppression of c-myc, Mafb, cyclin D1 and induction of p21(Waf1/Cip1), p53 and Bax mRNA expression...
  7. Ha H, Shim K, Kim T, Lee C, Park J, Kim H, et al. Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss. BMC Complement Altern Med. 2014;14:352 pubmed publisher
    ..WEAO also inhibited RANKL-induced down-regulation of Id2 and MafB, negative regulators of NFATc1. WEAO does not directly affect bone resorbing activity of mature osteoclasts...
  8. Waqas S, Hoang A, Lin Y, Ampem G, Azegrouz H, Balogh L, et al. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017;127:2842-2854 pubmed publisher
    ..and suppressed the transcription of Ifi200 cell-cycle inhibitor family members and MAF bZIP transcription factor B (Mafb), a negative regulator of macrophage proliferation...
  9. Grieco G, Cataldo D, Ceccarelli E, Nigi L, Catalano G, Brusco N, et al. Serum Levels of miR-148a and miR-21-5p Are Increased in Type 1 Diabetic Patients and Correlated with Markers of Bone Strength and Metabolism. Noncoding RNA. 2018;4: pubmed publisher
    ..target genes prediction analysis revealed several factors involved in bone development and remodeling, such as MAFB, WNT1, TGFB2, STAT3, or PDCD4, and the co-modulation of common pathways involved in bone homeostasis thus ..

More Information

Publications154 found, 100 shown here

  1. Enkhmandakh B, Bayarsaihan D. Genome-wide Chromatin Mapping Defines AP2? in the Etiology of Craniofacial Disorders. Cleft Palate Craniofac J. 2015;52:135-42 pubmed publisher
    ..regions of many target genes involved in the development of facial tissues including MSX1, IRF6, TBX22, and MAFB. In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2? consensus ..
  2. Feng Y, Zheng M, Gan S, Zhang L, Wan Z, Zhang Y, et al. Identification of potential gene targets in systemic vasculitis using DNA microarray analysis. Mol Med Rep. 2017;15:3665-3673 pubmed publisher
    ..DEGs that were predicted to be TFs, STAT1, v‑maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) and tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein Z (YWHAZ), which ..
  3. Kimura T, Kuragano T, Yamamoto K, Nanami M, Hasuike Y, Nakanishi T. Deregulated iron metabolism in bone marrow from adenine-induced mouse model of chronic kidney disease. Int J Hematol. 2019;109:59-69 pubmed publisher
    ..In CKD mice, levels of erythroferrone mRNA in BM and splenic cells were significantly decreased, and MafB protein levels in BM cells were significantly increased...
  4. Dewangan P, Panigrahi M, Kumar A, Saravanan B, Ghosh S, Asaf V, et al. The mRNA expression of immune-related genes in crossbred and Tharparkar cattle in response to in vitro infection with Theileria annulata. Mol Biol Rep. 2015;42:1247-55 pubmed publisher
    ..significant up-regulation in SIRPA, PRNP and MHC DQα genes and significant down-regulation in TLR10, cMAF and MAFB genes in crossbreds as compared to indigenous cattle was observed...
  5. Li B, Ding L, Yang C, Kang B, Liu L, Story M, et al. Characterization of transcription factor networks involved in umbilical cord blood CD34+ stem cells-derived erythropoiesis. PLoS ONE. 2014;9:e107133 pubmed publisher
    ..in KU812 leukemia cells and human erythroid progenitors generated from UCB-CD34+ cells supported a negative role of MAFB in γ-globin regulation...
  6. Nishimura W, Takahashi S, Yasuda K. MafA is critical for maintenance of the mature beta cell phenotype in mice. Diabetologia. 2015;58:566-74 pubmed publisher
    ..cells in db/db and multiple low-dose streptozotocin mice underwent similar dedifferentiation with expression of Mafb, which is expressed in immature beta cells...
  7. Jablonski K, Gaudet A, Amici S, Popovich P, Guerau de Arellano M. Control of the Inflammatory Macrophage Transcriptional Signature by miR-155. PLoS ONE. 2016;11:e0159724 pubmed publisher
    ..datasets confirmed that miR-155 contributed to suppression of its validated mRNA targets Inpp5d, Tspan14, Ptprj and Mafb and induction of Inos, Il1b, Tnfa, Il6 and Il12...
  8. Csajbók É, Kocsis A, Faragó N, Furdan S, Kovacs B, Lovas S, et al. Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex. Diabetologia. 2019;62:717-725 pubmed publisher
    ..single-cell digital PCR of neurogliaform cells revealed that the expression of transcription factors (Pdx1, Isl1, Mafb) are important in beta cell development...
  9. Borrelli S, Fanoni D, Dolfini D, Alotto D, Ravo M, Grober O, et al. C/EBPδ gene targets in human keratinocytes. PLoS ONE. 2010;5:e13789 pubmed publisher
    ..Functional inactivation of C/EBPδ as well as overexpressions of two TF targets--MafB and SOX2--affect expression of markers of keratinocyte differentiation...
  10. Li F, Su Y, Cheng Y, Jiang X, Peng Y, Li Y, et al. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development. Endocrinology. 2015;156:48-57 pubmed publisher
    ..homeobox POU domain protein 4 (Brn4) and v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MafB). Moreover, the inactivation of β-cell-specific transcription factors was observed in mutant β-cells...
  11. Asakawa K, Kawakami K. Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens Nucleus. Cell Rep. 2018;24:1562-1572 pubmed publisher
    ..Disruptions of Duane retraction syndrome-associated transcription factors reveal that these neurons require Mafba/MAFB, but not Sall4/SALL4, for differentiation...
  12. Stanescu D, Yu R, Won K, Stoffers D. Single cell transcriptomic profiling of mouse pancreatic progenitors. Physiol Genomics. 2017;49:105-114 pubmed publisher
    ..observed SLC38A5 expression in pancreatic progenitors, including in a subset of NEUROG3+ endocrine progenitors and MAFB+ cells and in all GCG+ cells...
  13. Lam C, Yeung H, Lam Y, Ng R. Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway. Leuk Res. 2018;68:112-119 pubmed publisher
    ..Inhibition of JNK suppressed the expression of key myeloid transcriptional regulators c-JUN, SPI-1 and MAFB, and prevented AML cells from undergoing terminal differentiation...
  14. Jamet A, Nassif X. New players in the toxin field: polymorphic toxin systems in bacteria. MBio. 2015;6:e00285-15 pubmed publisher
    ..We have recently characterized the MafB toxins, a new family of PTS deployed by pathogenic Neisseria spp...
  15. Chen J, Du Y, He X, Huang X, Shi Y. A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse. Sci Rep. 2017;7:517 pubmed publisher
    ..We further verified the efficacy of this novel strategy to target multiple sites by deleting c-Maf and MafB simultaneously in macrophages specifically...
  16. Naveh Many T, Silver J. Transcription factors that determine parathyroid development power PTH expression. Kidney Int. 2018;93:7-9 pubmed publisher
    ..Among the transcription factors essential for parathyroid development, Gata3, GCM2, and MafB, are expressed in the developing parathyroids as well as postnatally, implying that they also regulate parathyroid-..
  17. Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, et al. Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nat Biotechnol. 2009;27:1038-42 pubmed publisher
    ..Some beta cells from pregnant animals were found to express Mafb, previously observed only in immature beta cells during embryonic development...
  18. Park S, Huh J, Shin J, Park D, Ko R, Jin G, et al. Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation. Sci Rep. 2016;6:26186 pubmed publisher
    ..maturation protein-1 (Blimp1) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb. These findings identify Sirt6 as a novel regulator of osteoclastogenesis by acting as a transcriptional repressor.
  19. Julià A, Fernandez Nebro A, Blanco F, Ortiz A, Cañete J, Maymó J, et al. A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis. Pharmacogenomics J. 2016;16:147-50 pubmed publisher
    ..replicated the association at the MED15 locus and found suggestive evidence of association in the previously associated MAFB locus. The results of this study suggest novel mechanisms associated with the response to anti-TNF therapies.
  20. Lim L, Pakan J, Selten M, Marques Smith A, Llorca A, Bae S, et al. Optimization of interneuron function by direct coupling of cell migration and axonal targeting. Nat Neurosci. 2018;21:920-931 pubmed publisher
    ..Altering the normal migratory route of Martinotti cells by conditional deletion of Mafb-a gene that is preferentially expressed by these cells-cell-autonomously disrupts axonal development and impairs ..
  21. Klein R, Andersen B. Dynamic networking for epidermal differentiation. Dev Cell. 2015;32:661-2 pubmed publisher
    ..2015) identify regulatory networks that are controlled by the transcriptional regulators MAF:MAFB. These networks play a crucial and previously unrecognized role in epidermal differentiation, functioning both to ..
  22. Yin X, Yu H, Jin X, Li J, Guo H, Shi Q, et al. Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions. J Immunol. 2017;198:1553-1564 pubmed publisher
    ..CD5low DCs preferentially expressed monocyte-related genes, including the lineage-specific transcription factor MAFB. Furthermore, compared with the CD5low subpopulation, the CD5high subpopulation ..
  23. Cyphert H, Walker E, Hang Y, Dhawan S, Haliyur R, Bonatakis L, et al. Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally. Diabetes. 2019;68:337-348 pubmed publisher
    The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice...
  24. Onodera K, Fujiwara T, Onishi Y, Itoh Nakadai A, Okitsu Y, Fukuhara N, et al. GATA2 regulates dendritic cell differentiation. Blood. 2016;128:508-18 pubmed publisher
    ..Moreover, expression profiling demonstrated reduced expression of myeloid-related genes, including mafb, and increased expression of T-lymphocyte-related genes, including Gata3 and Tcf7, in Gata2-deficient DC ..
  25. Kann M, Ettou S, Jung Y, Lenz M, Taglienti M, Park P, et al. Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 2015;26:2097-104 pubmed publisher
    ..transcription factor network consisting of WT1, LMX1B, TCF21, Fox-class and TEAD family transcription factors, and MAFB that uses tissue-specific enhancers to control podocyte gene expression...
  26. Daassi D, Hamada M, Jeon H, Imamura Y, Nhu Tran M, Takahashi S. Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem Biophys Res Commun. 2016;473:118-124 pubmed publisher
    The large Maf transcription factors c-Maf and MafB are expressed in macrophage-lineage hematopoietic cells, but the expression patterns of MafB and c-Maf in macrophage subtypes and tissue-resident macrophages have not been fully analyzed...
  27. Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, et al. Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. J Am Soc Nephrol. 2015;26:2118-28 pubmed publisher
    ..conservation of WT1 targets, we performed functional assays using zebrafish as a model and identified Nphs2, Mafb, and Magi2 as novel WT1 target genes required for podocyte development...
  28. Raum J, Soleimanpour S, Groff D, Coré N, Fasano L, Garratt A, et al. Tshz1 Regulates Pancreatic β-Cell Maturation. Diabetes. 2015;64:2905-14 pubmed publisher
    ..1) and α-cell (MafB and Arx) formation and function are downregulated...
  29. Tani Matsuhana S, Vieceli F, Gandhi S, Inoue K, Bronner M. Transcriptome profiling of the cardiac neural crest reveals a critical role for MafB. Dev Biol. 2018;444 Suppl 1:S209-S218 pubmed publisher
    ..We then functionally tested the role of one of the upregulated transcription factors, MafB, and found that it acts as a regulator of Sox10 expression specifically in the cardiac neural crest...
  30. Suzuki K, Numata T, Suzuki H, Raga D, Ipulan L, Yokoyama C, et al. Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation. Proc Natl Acad Sci U S A. 2014;111:16407-12 pubmed publisher
    ..genitalia through the identification of the v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (Mafb) gene...
  31. Chang N, Doherty J, Ensign A. JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. J Biol Chem. 2003;278:9195-202 pubmed
    ..This mutant protein bound p53 but could not interact with JNK1, as determined in yeast two-hybrid analysis. Taken together, phosphorylation of JNK1 and WOX1 is necessary for their physical interaction and functional antagonism. ..
  32. Volk D, Edelson J, Lewis D. Altered expression of developmental regulators of parvalbumin and somatostatin neurons in the prefrontal cortex in schizophrenia. Schizophr Res. 2016;177:3-9 pubmed publisher
    ..to unaffected comparison subjects, subjects with schizophrenia exhibited elevated mRNA levels for 1) the transcription factor MafB, which is expressed by parvalbumin and somatostatin neurons as they migrate from the medial ganglionic ..
  33. Koshida R, Oishi H, Hamada M, Takei Y, Takahashi S. MafB is required for development of the hindbrain choroid plexus. Biochem Biophys Res Commun. 2017;483:288-293 pubmed publisher
    ..However, molecular mechanisms underlying ChP development are poorly understood compared to neural development. MafB is a bZip transcription factor that is known to be expressed in the roof plate...
  34. Sato Y, Tsukaguchi H, Morita H, Higasa K, Tran M, Hamada M, et al. A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. Kidney Int. 2018;94:396-407 pubmed publisher
    ..Genetic analyses revealed that affected individuals harbor a rare heterozygous substitution (p.Leu239Pro) in MAFB, a leucine zipper transcription factor...
  35. Nishimura W, Oishi H, Funahashi N, Fujiwara T, Takahashi S, Yasuda K. Generation and characterization of MafA-Kusabira Orange mice. Endocr J. 2015;62:37-51 pubmed publisher
    MafA and MafB are basic leucine zipper transcription factors expressed in mature pancreatic β- and α-cells, respectively...
  36. Panigrahi M, Kumar A, Bhushan B, Ghosh S, Saravanan B, Sulabh S, et al. No change in mRNA expression of immune-related genes in peripheral blood mononuclear cells challenged with Theileria annulata in Murrah buffalo (Bubalus bubalis). Ticks Tick Borne Dis. 2016;7:754-758 pubmed publisher
    ..fibrosarcoma oncogene homolog (cMAF) and V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) genes influence host resistance to this disease in exotic, crossbred and indigenous cattle...
  37. Banerjee R, Cyphert H, Walker E, Chakravarthy H, Peiris H, Gu X, et al. Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet ?-Cells. Diabetes. 2016;65:2331-41 pubmed publisher
    ..system also revealed that PRLR signaling is required for the transient gestational expression of the transcription factor MafB within a subset of ?-cells during pregnancy...
  38. Matsushita S, Suzuki K, Ogino Y, Hino S, Sato T, Suyama M, et al. Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization. Endocrinology. 2016;157:844-57 pubmed publisher
    ..We have previously shown that v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is an androgen-inducible regulator of embryonic urethral masculinization in mice...
  39. Butovsky O, Jedrychowski M, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, et al. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015;77:75-99 pubmed publisher
    ..There was loss of the microglial molecules P2ry12, Tmem119, Olfml3, transcription factors Egr1, Atf3, Jun, Fos, and Mafb, and the upstream regulators Csf1r, Tgfb1, and Tgfbr1, which are essential for microglial survival...
  40. Gemelli C, Zanocco Marani T, Bicciato S, Mazza E, Boraschi D, Salsi V, et al. MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation. Biochim Biophys Acta. 2014;1843:955-64 pubmed publisher
    In spite of the numerous reports implicating MafB transcription factor in the molecular control of monocyte-macrophage differentiation, the precise genetic program underlying this activity has been, to date, poorly understood...
  41. Abdellatif A, Ogata K, Kudo T, Xiafukaiti G, Chang Y, Katoh M, et al. Role of large MAF transcription factors in the mouse endocrine pancreas. Exp Anim. 2015;64:305-12 pubmed publisher
    ..5. In addition, Mafa(-/-);Mafb(-/-) mice contained less than 10% of the insulin transcript and protein of those of wild-type mice, suggesting that ..
  42. Hasan S, Johnson N, Mosier M, Shankar R, Conrad P, Szilagyi A, et al. Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation. Am J Physiol Cell Physiol. 2017;312:C286-C301 pubmed publisher
    ..to burn patients, establishing the mechanistic regulation of erythroid commitment by myeloid regulatory transcription factor MafB. Overall, results demonstrate that β-adrenergic blockers following burn injury can redirect the ..
  43. Katoh M, Jung Y, Ugboma C, Shimbo M, Kuno A, Basha W, et al. MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo. Mol Cell Biol. 2018;38: pubmed publisher
    The MafB transcription factor is expressed in pancreatic α and β cells during development but becomes exclusive to α cells in adult rodents...
  44. Diedisheim M, Oshima M, Albagli O, Huldt C, Ahlstedt I, Clausen M, et al. Modeling human pancreatic beta cell dedifferentiation. Mol Metab. 2018;10:74-86 pubmed publisher
    ..Fibroblast growth factor 2 (FGF2) treatment reduced expression of β-cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3...
  45. Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo A, Miyagawa S, et al. Regulation of masculinization: androgen signalling for external genitalia development. Nat Rev Urol. 2018;15:358-368 pubmed publisher
    ..Androgen-induced genes, such as MAFB, which belongs to the activator protein 1 (AP-1) superfamily of genes, have essential roles in male urethral ..
  46. Breitling C, Gross A, Büttner P, Weise S, Schleinitz D, Kiess W, et al. Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children. PLoS ONE. 2015;10:e0138064 pubmed publisher
    To assess potential effects of variants in six lipid modulating genes (SORT1, HMGCR, MLXIPL, FADS2, APOE and MAFB) on early development of dyslipidemia independent of the degree of obesity in children, we investigated their association ..
  47. Chu Y, Zhao Z, Sant D, Zhu G, Greenblatt S, Liu L, et al. Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC). Genomics Proteomics Bioinformatics. 2018;16:172-186 pubmed publisher
    ..results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz...
  48. Menéndez Gutiérrez M, Rőszer T, Fuentes L, Núñez V, Escolano A, Redondo J, et al. Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest. 2015;125:809-23 pubmed publisher
    ..of the RXR-dependent transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MAFB) in osteoclast progenitors...
  49. Chang Z, Lichtenstein P, D Onofrio B, Almqvist C, Kuja Halkola R, Sjölander A, et al. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. Int J Epidemiol. 2014;43:1815-24 pubmed publisher
    ..Maternal age at first birth (MAFB) was associated with offspring ADHD...
  50. Qiang Y, Ye S, Huang Y, Chen Y, van Rhee F, Epstein J, et al. MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma. BMC Cancer. 2018;18:724 pubmed publisher
    ..Immunoblotting analysis was performed for MAFb and caspase family proteins...
  51. Nagasaki H, Katsumata T, Oishi H, Tai P, Sekiguchi Y, Koshida R, et al. Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb. PLoS ONE. 2014;9:e113022 pubmed publisher
    Recent studies on the large Maf transcription factors have shown that Mafb and Mafa have respective and distinctive roles in β-cell development and maturation...
  52. Lopez Pajares V, Qu K, Zhang J, Webster D, Barajas B, Siprashvili Z, et al. A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation. Dev Cell. 2015;32:693-706 pubmed publisher
    ..Module mapping of 1,046 TFs identified MAF and MAFB as necessary and sufficient for progenitor differentiation. MAF:MAFB regulated 393 genes altered in this setting...
  53. Scoville D, Cyphert H, Liao L, Xu J, Reynolds A, Guo S, et al. MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function. Diabetes. 2015;64:3772-83 pubmed publisher
    ..5 MDa Mll3 and Mll4 complexes in size-fractionated β-cell extracts. Likewise, closely related human MAFB, which is important to β-cell formation and coproduced with MAFA in adult human islet β-cells, bound MLL3 and ..
  54. Tsuchiya H, Oura S. Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion. Int J Mol Sci. 2018;19: pubmed publisher
    ..The musculo-aponeurotic fibrosarcoma oncogene homolog B (MAFB) significantly enhanced the activation of the TFPI2 promoter via RARα while MAFF inhibited it...
  55. Park P, Kim K, Hyun H, Lee C, Park J, Kie J, et al. Three cases of multicentric carpotarsal osteolysis syndrome: a case series. BMC Med Genet. 2018;19:164 pubmed publisher
    Multicentric carpotarsal osteolysis syndrome (MCTO) is characterized by progressive destruction and disappearance of the carpal and tarsal bones associated with nephropathy...
  56. Han S, Tsunekage Y, Kataoka K. Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1. Mol Cell Endocrinol. 2015;411:113-20 pubmed publisher
    ..Gata3 interacted with Gcm2 and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH promoter...
  57. Koshida R, Oishi H, Hamada M, Takahashi S. MafB antagonizes phenotypic alteration induced by GM-CSF in microglia. Biochem Biophys Res Commun. 2015;463:109-15 pubmed publisher
    ..However, how its signaling is modulated in microglia is poorly characterized. MafB, a bZip transcriptional factor, is highly expressed in monocyte-macrophage lineage cells including microglia, ..
  58. Park M, Kim H, Lee M, Park B, Lee H, Cho E, et al. FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Sci Rep. 2017;7:15575 pubmed publisher
    ..However, negative regulators of osteoclastogenesis such as MafB and IRF-8 were upregulated by FAM19A5...
  59. Chilton J, Guthrie S. Axons get ahead: Insights into axon guidance and congenital cranial dysinnervation disorders. Dev Neurobiol. 2017;77:861-875 pubmed publisher
    ..discovery that ocular motility disorders can arise from mutations in transcription factors, including HoxA1, HoxB1, MafB, Phox2A, and Sall4, has revealed gene regulatory networks that pattern the brainstem and/or govern the ..
  60. Lazarus S, Tseng H, Lawrence F, Woodruff M, Duncan E, Pettit A. Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. Am J Pathol. 2017;187:1923-1934 pubmed publisher
    ..and epiphyseal abnormalities, are caused by mutations in v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B (MAFB), matrix metalloproteinase (MMP) 2, and MMP14, respectively; however, the underlying pathophysiology is unclear...
  61. Olaso Gonzalez G, Ferrando B, Derbré F, Salvador Pascual A, Cabo H, Pareja Galeano H, et al. Redox regulation of E3 ubiquitin ligases and their role in skeletal muscle atrophy. Free Radic Biol Med. 2014;75 Suppl 1:S43-4 pubmed publisher
    ..NF-?B pathways, and the expression of two E3 ubiquitin ligases involved in proteolysis, the Muscle atrophy F-Box (MAFb) and Muscle RING Finger-1 (MuRF-1)...
  62. Suzuki T, Maeda S, Furuhata E, Shimizu Y, Nishimura H, Kishima M, et al. A screening system to identify transcription factors that induce binding site-directed DNA demethylation. Epigenetics Chromatin. 2017;10:60 pubmed publisher
    ..and identified eight novel binding site-directed DNA demethylation-inducing TFs (RUNX3, GATA2, CEBPB, MAFB, NR4A2, MYOD1, CEBPA, and TBX5)...
  63. Whitman M, Engle E. Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance. Hum Mol Genet. 2017;26:R37-R44 pubmed publisher
    ..by decreased function of several transcription factors critical for abducens motor neuron identity, including MAFB, or by heterozygous missense mutations in CHN1, which encodes ?2-chimaerin, a Rac-GAP GTPase that affects ..
  64. Arenas J, de Maat V, Catón L, Krekorian M, Herrero J, Ferrara F, et al. Fratricide activity of MafB protein of N. meningitidis strain B16B6. BMC Microbiol. 2015;15:156 pubmed publisher
    ..the toxic domains of TpsA and TpsC proteins as queries identified homologies with the C-terminal part of neisserial MafB proteins, which, for the rest, showed no sequence similarity to TpsA proteins...
  65. Hu W. Microarray analysis of PBMC after Plasmodium falciparum infection: Molecular insights into disease pathogenesis. Asian Pac J Trop Med. 2016;9:313-323 pubmed publisher
    ..In acute malaria, high MafB gene expression was negatively correlated with hemoglobin and platelet counts...
  66. Wu X, Briseño C, Durai V, Albring J, Haldar M, Bagadia P, et al. Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells. J Exp Med. 2016;213:2553-2565 pubmed
    ..In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP expression originate from ..
  67. Stoffel M, Le Beau M, Espinosa R, Bohlander S, Le Paslier D, Cohen D, et al. A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene. Proc Natl Acad Sci U S A. 1996;93:3937-41 pubmed
    ..The myeloid tumor suppressor gene was localized to an 18-centimorgan interval (approximately equal to 13 Mb) between RPN2 and D20S17. This physical map will facilitate the isolation of MODY1 and the myeloid tumor suppressor gene. ..
  68. Kim J, Badano J, Sibold S, Esmail M, Hill J, Hoskins B, et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet. 2004;36:462-70 pubmed
  69. Shen Y, Nicoletti P, Floratos A, Pirmohamed M, Molokhia M, Geppetti P, et al. Genome-wide association study of serious blistering skin rash caused by drugs. Pharmacogenomics J. 2012;12:96-104 pubmed publisher
    ..Our GWAS did not find common, highly penetrant genetic risk factors responsible for SJS/TEN events in the cases selected. ..
  70. Soucie E, Weng Z, Geirsdóttir L, Molawi K, Maurizio J, Fenouil R, et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science. 2016;351:aad5510 pubmed publisher
    ..Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network that controls self-..
  71. Nemoto T, Shibata Y, Inoue S, Igarashi A, Tokairin Y, Yamauchi K, et al. MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression. Biochem Biophys Res Commun. 2017;482:375-381 pubmed publisher
    This study was designed to investigate whether MafB influences the phagocytic activity of macrophages by modulating the expression of the Fc receptors for IgG (Fc?Rs), Fcgr2b and Fcgr3...
  72. Cuevas V, Anta L, Samaniego R, Orta Zavalza E, Vladimir de la Rosa J, Baujat G, et al. MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis. J Immunol. 2017;198:2070-2081 pubmed publisher
    ..We now report that knockdown of MAFB impairs the acquisition of the anti-inflammatory profile of human macrophages, identify the MAFB-dependent gene ..
  73. Clemente C, Rius C, Alonso Herranz L, Martín Alonso M, Pollán A, Camafeita E, et al. MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Nat Commun. 2018;9:910 pubmed publisher
    ..in higher numbers of patrolling monocytes crawling and adhered to inflamed endothelia, and the accumulation of Mafb+ apoptosis inhibitor of macrophage (AIM)+ macrophages at incipient atherosclerotic lesions in mice...
  74. Matcovitch Natan O, Winter D, Giladi A, Vargas Aguilar S, Spinrad A, Sarrazin S, et al. Microglia development follows a stepwise program to regulate brain homeostasis. Science. 2016;353:aad8670 pubmed publisher
    ..Knockout of the gene encoding the adult microglia transcription factor MAFB and environmental perturbations, such as those affecting the microbiome or prenatal immune activation, ..
  75. Nishimura K, Noda T, Dabdoub A. Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea. PLoS ONE. 2017;12:e0170568 pubmed publisher
    ..Here we systematically examined the spatiotemporal expression of five transcription factors: Sox2, Sox10, Gata3, Mafb, and Prox1 from early delamination at embryonic day (E) 10.5 to adult...
  76. Stralen E, Leguit R, Begthel H, Michaux L, Buijs A, Lemmens H, et al. MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients. Leukemia. 2009;23:801-3 pubmed publisher
  77. Yang W, Lan X, Li D, Li T, Lu S. MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells. BMC Cancer. 2015;15:461 pubmed publisher
    ..Real-time quantitative PCR and Western blotting were used to confirm miR-223 and MAFB expression levels...
  78. Miyai M, Hamada M, Moriguchi T, Hiruma J, Kamitani Kawamoto A, Watanabe H, et al. Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation. J Invest Dermatol. 2016;136:1848-1857 pubmed publisher
    ..We demonstrate that the transcription factor MafB is expressed in differentiating keratinocytes in mice and is transcriptionally upregulated upon human ..
  79. Hasegawa H, Watanabe T, Kato S, Toshima T, Yokoyama M, Aida Y, et al. The role of macrophage transcription factor MafB in atherosclerotic plaque stability. Atherosclerosis. 2016;250:133-43 pubmed publisher
    ..is associated with the development of atherosclerosis and plaque vulnerability and is regulated by transcription factor MafB. We previously reported that MafB attenuates macrophage apoptosis, which is associated with ..
  80. Sakai E, Morita M, Ohuchi M, Kido M, Fukuma Y, Nishishita K, et al. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J. 2017;31:4011-4022 pubmed publisher
    ..Furthermore, Keap1 deficiency up-regulated the expression of Mafb, a negative regulator of NFATc1...
  81. Pan Y, Zhang W, Du Y, Tong N, Han Y, Zhang H, et al. Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population. Am J Med Genet A. 2011;155A:2180-5 pubmed publisher
    ..a large-scale genome-wide association study identified two novel NSOC susceptibility loci: rs13041247 near MAFB and rs560426 near ABCA4...
  82. Pettersson A, Acosta J, Björk C, Krätzel J, Stenson B, Blomqvist L, et al. MAFB as a novel regulator of human adipose tissue inflammation. Diabetologia. 2015;58:2115-23 pubmed publisher
    ..The transcription factor V-maf musculoaponeurotic fibrosarcoma oncogene homologue B (MAFB) is highly expressed in human white adipose tissue (WAT)...
  83. Oh E, Lee H, Kim H, Park Y, Seo J, Park J, et al. Serum amyloid A inhibits RANKL-induced osteoclast formation. Exp Mol Med. 2015;47:e194 pubmed publisher
    ..factor 6 and osteoclast-associated receptor) but also strongly induced the expression of negative regulators (MafB and interferon regulatory factor 8)...
  84. Duan S, Huang N, Zhang B, Shi J, He S, Ma J, et al. New insights from GWAS for the cleft palate among han Chinese population. Med Oral Patol Oral Cir Bucal. 2017;22:e219-e227 pubmed
    ..80E-08) and rs6072081 (53kb 3' of MAFB) interacted with rs6102085 (33kb 3' of MAFB) (p-value=3...
  85. Zhuang L, Adler S, Aeberli D, Villiger P, Trueb B. Identification of a MAFB mutation in a patient with multicentric carpotarsal osteolysis. Swiss Med Wkly. 2017;147:w14529 pubmed publisher
    Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones...
  86. Shawki H, Oishi H, Usui T, Kitadate Y, Basha W, Abdellatif A, et al. MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. PLoS ONE. 2018;13:e0190800 pubmed publisher
    The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues...
  87. Chen Z, Su L, Xu Q, Katz J, Michalek S, Fan M, et al. IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1). J Biol Chem. 2015;290:30163-74 pubmed publisher
    ..protein-1 (Blimp1), a global transcriptional repressor of anti-osteoclastogenic genes encoding Bcl6, IRF8, and MafB. However, IL-1 enhances RANKL-induced blimp1 gene expression but suppresses the gene expression of bcl6, irf8, and ..
  88. Hasan S, Mosier M, Szilagyi A, Gamelli R, MUTHUMALAIAPPAN K. Discrete ?-adrenergic mechanisms regulate early and late erythropoiesis in erythropoietin-resistant anemia. Surgery. 2017;162:901-916 pubmed publisher
    ..Multipotential progenitors were probed for MafB expressing cells...
  89. Vicente Dueñas C, Romero Camarero I, González Herrero I, Alonso Escudero E, Abollo Jiménez F, Jiang X, et al. A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors. EMBO J. 2012;31:3704-17 pubmed publisher
    ..that might take place in the development of plasma cell neoplasias, we engineered transgenic mice to express MafB in haematopoietic stem/progenitor cells (HS/PCs)...
  90. Wang S, Juan J, Zhang Z, Du Y, Xu Y, Tong J, et al. Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Cell Death Dis. 2017;8:e3058 pubmed publisher
    ..Notably, MafA and MafB are also members of the c-Maf family, however, USP5 failed to deubiquitinate MafA, suggesting its substrate ..
  91. Mechta Grigoriou F, Giudicelli F, Pujades C, Charnay P, Yaniv M. c-jun regulation and function in the developing hindbrain. Dev Biol. 2003;258:419-31 pubmed
    Hindbrain development is a well-characterised segmentation process in vertebrates. The bZip transcription factor MafB/kreisler is specifically expressed in rhombomeres (r) 5 and 6 of the developing vertebrate hindbrain and is required ..
  92. Sevinsky J, Whalen A, Ahn N. Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler. Mol Cell Biol. 2004;24:4534-45 pubmed
    ..b>MafB/Kreisler is induced in response to ERK and synergizes with GATA and Ets to enhance transcription from the proximal ..