MAF

Summary

Gene Symbol: MAF
Description: MAF bZIP transcription factor
Alias: AYGRP, CCA4, CTRCT21, c-MAF, transcription factor Maf, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene, T lymphocyte c-maf long form, c-maf proto-oncogene, proto-oncogene c-Maf, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Species: human
Products:     MAF

Top Publications

  1. Hedge S, Kumar A, Kurschner C, Shapiro L. c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. Mol Cell Biol. 1998;18:2729-37 pubmed
    ..To determine the effects of Maf family proteins on the transactivation of myeloid-specific genes in myeloid cells, we tested the ability of c-Maf ..
  2. Liu T, Yang H, Fan W, Tu J, Li T, Wang J, et al. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018;155:557-571.e14 pubmed publisher
    b>MAF bZIP transcription factor G (MAFG) is activated by the farnesoid X receptor to repress bile acid synthesis. However, expression of MAFG increases during cholestatic liver injury in mice and in cholangiocarcinomas...
  3. Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher
    ..protein 2B; LAMP2C: lysosomal associated membrane protein 2C; LAMP1: lysosomal associated membrane protein 1; MAFF: MAF bZIP transcription factor F; MAFK: MAF bZIP transcription factor K; NFE2L2/NRF2: nuclear factor, erythroid derived ..
  4. Nammo T, Udagawa H, Funahashi N, Kawaguchi M, Uebanso T, Hiramoto M, et al. Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice. Diabetologia. 2018;61:2608-2620 pubmed publisher
    ..and myocyte enhancer factor 2A (MEF2A) by de novo motif analysis, whereas decreased H3K27ac was enriched for v-maf musculoaponeurotic fibrosarcoma oncogene family protein K (MAFK), a known negative regulator of beta cells...
  5. Whitson J, Wilmarth P, Klimek J, Monnier V, David L, Fan X. Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins. Free Radic Biol Med. 2017;113:84-96 pubmed publisher
    ..05, FDR<0.1) altered protein expression compared to WT controls. HSF4 and MAF transcription factors were the most common upstream regulators of the response to GSH-deficiency...
  6. Wang M, Wu Q, Xie H, Shao Y, Zhong M, Zhang X, et al. Effects of Sleeve Gastrectomy on Serum 12α-Hydroxylated Bile Acids in a Diabetic Rat Model. Obes Surg. 2017;27:2912-2918 pubmed publisher
    ..Cholesterol 12α-hydroxylase (CYP8B1) and transcription factor V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (MAFG) expression levels were assessed by RT-PCR and ..
  7. Wu H, Liu Y, Wang H, Xu X. High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway. Int J Clin Exp Pathol. 2015;8:5196-202 pubmed
    ..transcription factor and its target genes in pancreas, such as pancreatic and duodenal homeobox factor-1 (Pdx1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) and glucose transporter 2 (Glut2) were decreased ..
  8. Haque M, Bose P, Siddique M, Sunita P, Lapenna A, Pattanayak S. Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. Biomed Pharmacother. 2018;105:27-36 pubmed publisher
    ..These results validate the anti-cancer potential of TAX in DMBA-induced MC through LXR-mTOR/Maf1/PTEN axis. ..
  9. Gęgotek A, Skrzydlewska E. The role of transcription factor Nrf2 in skin cells metabolism. Arch Dermatol Res. 2015;307:385-96 pubmed publisher
    ..g., Maf, IKKβ) or inhibitors (e.g., Bach1, caveolae, TGF-β). Moreover, there are a number of drugs (e.g...

More Information

Publications149 found, 100 shown here

  1. Zhou Y, Wu H, Zhao M, Chang C, Lu Q. The Bach Family of Transcription Factors: A Comprehensive Review. Clin Rev Allergy Immunol. 2016;50:345-56 pubmed publisher
    ..to a basic region-leucine zipper (bZip) family, repress target gene expression by forming heterodimers with small Maf proteins...
  2. Song Z, Si N, Xiao W. A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family. BMC Med Genet. 2018;19:190 pubmed publisher
    ..All coding exons and flanking regions of seven candidate genes (CRYAA, CRYBA4, CRYBB2, CRYGC, GJA8, MAF, and PITX3) were amplified and sequenced...
  3. Wilson L, Wong S, Yu N, Geras Raaka E, Raaka B, Gershengorn M. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells. 2009;27:2703-11 pubmed publisher
    ..known to induce transcription of this gene in beta cells, pancreatic and duodenal homeobox factor 1 (Pdx1), V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (Mafa), and neurogenic differentiation 1 (Neurod1), would ..
  4. Wang L, Huang Y, Guo Q, Fan X, Lu Y, Zhu S, et al. Differentiation of iPSCs into insulin-producing cells via adenoviral transfection of PDX-1, NeuroD1 and MafA. Diabetes Res Clin Pract. 2014;104:383-92 pubmed publisher
    ..the effect of PDX-1 (pancreatic and duodenal homeobox-1), NeuroD1 (neurogenic differentiation-1) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) in the differentiation of induced pluripotent stem cells (iPSCs)..
  5. Choi J, Ting C, Trogrlic L, Milevski S, Familari M, Martinez G, et al. A role for smoothened during murine lens and cornea development. PLoS ONE. 2014;9:e108037 pubmed publisher
    ..5. Mutant lenses were smaller and showed normal expression of p57Kip2, c-Maf, E-cadherin and Pax6, reduced expression of FoxE3 and Ptch1 and decreased nuclear Hes1...
  6. Yu H, Jiang H, Xu D, Jin J, Zhao Z, Ma Y, et al. Transcription Factor MafB Promotes Hepatocellular Carcinoma Cell Proliferation through Up-Regulation of Cyclin D1. Cell Physiol Biochem. 2016;39:700-8 pubmed publisher
    MafB, a member of the Maf transcription factor family, plays a key role in the regulation of pancreatic alpha and beta cell differentiation. However, its function in the control of cancer cell proliferation remains unknown...
  7. Gao C, Wang N, Guo X, Ziegler J, Taylor K, Xiang A, et al. A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS). PLoS ONE. 2015;10:e0134649 pubmed publisher
    ..A missense SNP in the isocitrate dehydrogenase 1 gene (IDH1) was associated with WAIST (rs34218846, MAF = 6.8%, PDOM = 1.62x10-8)...
  8. Geng X, Qiu S, Yang L, Liu Z, Yang G, Liu J, et al. Allergen-specific immune response suppresses interleukin 10 expression in B cells via increasing micro-RNA-17-92 cluster. Cell Biochem Funct. 2016;34:449-54 pubmed publisher
    ..The levels of histone deacetylase 11 and acetylated H3K9 were higher, and the RNA polymerase II and c-Maf (the IL-10 transcription factor) were lower, at the IL-10 promoter locus...
  9. Fang Y, van Meurs J, Arp P, van Leeuwen J, Hofman A, Pols H, et al. Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int. 2009;85:85-93 pubmed publisher
    ..DBP can also be converted to DBP-macrophage activating factor (DBP-MAF), which mediates bone resorption by directly activating osteoclasts...
  10. Lacher S, Lee J, Wang X, Campbell M, Bell D, Slattery M. Beyond antioxidant genes in the ancient Nrf2 regulatory network. Free Radic Biol Med. 2015;88:452-465 pubmed publisher
    ..Nrf2 is structurally and functionally conserved from insects to humans, and it heterodimerizes with the small MAF transcription factors to bind a consensus DNA sequence (the antioxidant response element, or ARE) and regulate gene ..
  11. Waqas S, Hoang A, Lin Y, Ampem G, Azegrouz H, Balogh L, et al. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017;127:2842-2854 pubmed publisher
    ..gene 2 (Ndrg2) expression and suppressed the transcription of Ifi200 cell-cycle inhibitor family members and MAF bZIP transcription factor B (Mafb), a negative regulator of macrophage proliferation...
  12. Hao H, Veleri S, Sun B, Kim D, Keeley P, Kim J, et al. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Hum Mol Genet. 2014;23:4260-71 pubmed publisher
    The Maf-family leucine zipper transcription factor NRL is essential for rod photoreceptor development and functional maintenance in the mammalian retina...
  13. Cameron J, Levandovskiy V, Roberts W, Anagnostou E, Scherer S, Loh A, et al. Variability of Creatine Metabolism Genes in Children with Autism Spectrum Disorder. Int J Mol Sci. 2017;18: pubmed publisher
    ..Nine variants in GATM were shown to have a lower minor allele frequency (MAF) in the autism population than in the 1000 Genomes database, specifically in the East Asian population (Fisher's ..
  14. Liu J, Chen X, Gu N, Zhang J, Jiang L, Zhang D, et al. Correlation study on chromogranin A genetic polymorphism and prognosis of critically ill patients. J Crit Care. 2017;39:137-142 pubmed publisher
    ..2) The CHGA-415 T/C MAF of the nonsurvival group was significantly higher than that of the survival group (MAF 0.3813 and 0...
  15. Hill E, Ng T, Burton B, Oakley C, Malik K, Wraith D. Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Eur J Immunol. 2015;45:1103-15 pubmed publisher
    ..Additionally, GSK3 inhibition increased expression of the transcription factors c-Maf, Nfil3, and GATA3, correlating with the increase in IL-10...
  16. Ruth K, Beaumont R, Tyrrell J, Jones S, Tuke M, Yaghootkar H, et al. Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod. 2016;31:473-81 pubmed publisher
    ..The FSH-lowering T allele of the FSHB promoter polymorphism (rs10835638; MAF 0.16) was associated with longer menstrual cycles [0.16 SD (c...
  17. Min X, Huang P, Liu X, Dong C, Jiang X, Yuan Z, et al. Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma. Tumour Biol. 2015;36:7457-63 pubmed publisher
    ..Among the 11 prognostic risk genes, v-maf avian musculoaponeurotic fibrosarcoma oncogene homologue F (MAFF), SRY (sex-determining region Y)-box 4 (SOX4), and ..
  18. Pettersson A, Acosta J, Björk C, Krätzel J, Stenson B, Blomqvist L, et al. MAFB as a novel regulator of human adipose tissue inflammation. Diabetologia. 2015;58:2115-23 pubmed publisher
    ..The transcription factor V-maf musculoaponeurotic fibrosarcoma oncogene homologue B (MAFB) is highly expressed in human white adipose tissue (WAT)...
  19. Menéndez Gutiérrez M, Rőszer T, Fuentes L, Núñez V, Escolano A, Redondo J, et al. Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest. 2015;125:809-23 pubmed publisher
    ..bone mass associated with RXR deficiency was due to lack of expression of the RXR-dependent transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MAFB) in osteoclast progenitors...
  20. Wang D, Poi M, Sun X, Gaedigk A, Leeder J, Sadee W. Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity. Hum Mol Genet. 2014;23:268-78 pubmed publisher
    ..polymorphisms, we find that a SNP defining the CYP2D6*2 allele, rs16947 [R296C, 17-60% minor allele frequency (MAF)], previously thought to convey normal activity, alters exon 6 splicing, thereby reducing CYP2D6 expression at ..
  21. Yamaoka M, Maeda N, Takayama Y, Sekimoto R, Tsushima Y, Matsuda K, et al. Adipose hypothermia in obesity and its association with period homolog 1, insulin sensitivity, and inflammation in fat. PLoS ONE. 2014;9:e112813 pubmed publisher
    ..Per1 mRNA was mainly expressed in the mature adipocyte fraction (MAF) and it was significantly low in MAF of ob/ob mice...
  22. Earp M, Brooks Wilson A, Cook L, Le N. Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk. BMC Res Notes. 2013;6:425 pubmed publisher
    ..A panel of 64 MT-SNPs designed to tag all common variation in the European MT genome (minor allele frequency (MAF) >1%, r^2 >0...
  23. Zhang Z, Leir S, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015;52:387-96 pubmed publisher
    ..ARE is occupied by the repressor BTB and CNC homology 1, basic leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) heterodimers...
  24. Wen X, Yang Y. Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. J Mol Endocrinol. 2017;58:R73-R85 pubmed publisher
    ..GLIS3 cooperates with pancreatic and duodenal homeobox 1 (PDX1), v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (MAFA), as well as neurogenic differentiation 1 (NEUROD1)..
  25. Lebedeva I, Pande P, Patton W. Sensitive and specific fluorescent probes for functional analysis of the three major types of mammalian ABC transporters. PLoS ONE. 2011;6:e22429 pubmed publisher
    ..kinetics and high sensitivity of MDR detection, as established by multidrug resistance activity factor (MAF) values and Kolmogorov-Smirnov statistical analysis...
  26. Hu X, Nie Q, Yi M, Li T, Wang Z, Huang Z, et al. The tumor suppressor, p53 regulates the γA-crystallin gene during mouse lens development. Curr Mol Med. 2014;14:1197-204 pubmed
    ..Regarding the mechanism, we reveal that p53 directly regulates several genes including c-Maf and Prox1, two important transcription factors for lens differentiation, and αA and βA3/A1, the lens ..
  27. Zhu Y, Liu Q, Zhou Z, Ikeda Y. PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration. Stem Cell Res Ther. 2017;8:240 pubmed publisher
    ..Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) are transcription factors critical for beta cell ..
  28. Mann G. Nrf2-mediated redox signalling in vascular health and disease. Free Radic Biol Med. 2014;75 Suppl 1:S1 pubmed publisher
    ..cysteine residues leads to nuclear accumulation of Nrf2 via de novo synthesis, and in the nucleus Nrf2 binds to a Maf recognition/antioxidant response element in the promoter of phase II and antioxidant genes, such as NQO1, HO-1, and ..
  29. McVeigh T, Mulligan R, McVeigh U, Owens P, Miller N, Bell M, et al. Investigating the association of rs2910164 with cancer predisposition in an Irish cohort. Endocr Connect. 2017;6:614-624 pubmed publisher
    ..The variant was detected with a minor allele frequency (MAF) of 0.19 in controls, 0.22 in BC and 0.27 and 0.26 in DTC cases from Ireland and France, respectively...
  30. Zhao Y, Zheng D, Cvekl A. A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells. Exp Eye Res. 2018;175:56-72 pubmed publisher
    ..g. E2Fs, Etv5, Hsf4, c-Maf, MafG, MafK, N-Myc, and Pax6) transcription factors and a number of novel regulators of lens formation, such as ..
  31. Zhu M, Wei Y, Geisler C, Abschlag K, Corbalán Campos J, Hristov M, et al. Hyperlipidemia-Induced MicroRNA-155-5p Improves ?-Cell Function by Targeting Mafb. Diabetes. 2017;66:3072-3084 pubmed publisher
    ..This effect of miR-155-5p is because of suppression of v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B, which promotes ?-cell function through IL-6-induced GLP-..
  32. Murk W, Dewan A. Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases. G3 (Bethesda). 2016;6:2043-50 pubmed publisher
    ..interactions among approximately N = 300,000 single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) ? 0...
  33. Janiszewska J, Szaumkessel M, Kostrzewska Poczekaj M, Bednarek K, Paczkowska J, Jackowska J, et al. Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma. PLoS ONE. 2015;10:e0144924 pubmed publisher
    ..in connection with functional analysis we delineated two putative target genes of miR-1290 namely ITPR2 and MAF which are significantly downregulated in LSCC...
  34. Ohguchi H, Hideshima T, Bhasin M, Görgün G, Santo L, Cea M, et al. The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival. Nat Commun. 2016;7:10258 pubmed publisher
    ..stromal cells and reduces MM cell homing to the bone marrow, in association with decreased ITGB7 expression in MAF-translocated MM cell lines...
  35. Hixson J, Jun G, Shimmin L, Wang Y, Yu G, Mao C, et al. Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons. Sci Rep. 2017;7:4091 pubmed publisher
    ..Our statistical analyses included single variant analysis for common variants (MAF > 0.01) and rare variant analysis for low frequency and rare variants (MAF < 0.05)...
  36. Zhang P, Fan Y, Li Q, Chen J, Zhou W, Luo Y, et al. Macrophage activating factor: A potential biomarker of periodontal health status. Arch Oral Biol. 2016;70:94-99 pubmed publisher
    ..Macrophage-activating factor (MAF) and macrophage-chemotactic factor (MCF) are two important mediators involved in macrophage accumulation, ..
  37. Reimondo G, Chiodini I, Puglisi S, Pia A, Morelli V, Kastelan D, et al. Analysis of BCLI, N363S and ER22/23EK Polymorphisms of the Glucocorticoid Receptor Gene in Adrenal Incidentalomas. PLoS ONE. 2016;11:e0162437 pubmed publisher
    ..SNP frequency was: SNP frequency was: N363S 5.4% (MAF 0.027), BclI 54.7% (MAF 0.328), ER22/23EK 4.4% (MAF 0...
  38. Lazarus S, Tseng H, Lawrence F, Woodruff M, Duncan E, Pettit A. Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. Am J Pathol. 2017;187:1923-1934 pubmed publisher
    ..skeletal dysplasias characterized by carpal/tarsal and epiphyseal abnormalities, are caused by mutations in v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B (MAFB), matrix metalloproteinase (MMP) 2, and MMP14, ..
  39. Saxena P, Bojar D, Zulewski H, Fussenegger M. Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network. J Biotechnol. 2017;259:39-45 pubmed publisher
    ..factors Ngn3 (neurogenin 3, OFF-ON-OFF), Pdx1 (pancreatic and duodenal homeobox 1, ON-OFF-ON) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A, OFF-ON) to guide the differentiation of IPSC-derived ..
  40. Ni B, Lin Y, Sun L, Zhu M, Li Z, Wang H, et al. Low-frequency germline variants across 6p22.2-6p21.33 are associated with non-obstructive azoospermia in Han Chinese men. Hum Mol Genet. 2015;24:5628-36 pubmed publisher
    ..heritability remains undefined, especially those low-frequency [defined here as having a minor allele frequency (MAF) between 0.5 and 5%] and rare (MAF below 0.5%) variants...
  41. Daassi D, Hamada M, Jeon H, Imamura Y, Nhu Tran M, Takahashi S. Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem Biophys Res Commun. 2016;473:118-124 pubmed publisher
    The large Maf transcription factors c-Maf and MafB are expressed in macrophage-lineage hematopoietic cells, but the expression patterns of MafB and c-Maf in macrophage subtypes and tissue-resident macrophages have not been fully analyzed...
  42. Kalsi M, Palli S. Cap n collar transcription factor regulates multiple genes coding for proteins involved in insecticide detoxification in the red flour beetle, Tribolium castaneum. Insect Biochem Mol Biol. 2017;90:43-52 pubmed publisher
    ..heterodimer of xenobiotic transcription factors, cap n collar C isoform (CncC) and muscle aponeurosis fibromatosis (Maf) mediate cellular defense...
  43. Annunziata C, Hernandez L, Davis R, Zingone A, Lamy L, Lam L, et al. A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression. Blood. 2011;117:2396-404 pubmed publisher
    ..myelomas, the initiating oncogenic event is translocation of musculoaponeurotic fibrosarcoma oncogene homolog (MAF), a transcriptional activator of key target genes, including cyclinD2...
  44. Johnson D, Covington A, Clark N. Design and Use of a Full Flow Sampling System (FFS) for the Quantification of Methane Emissions. J Vis Exp. 2016;: pubmed publisher
    ..The FFS is a modular system that consists of an explosive-proof blower(s), mass airflow sensor(s) (MAF), thermocouple, sample probe, constant volume sampling pump, laser based greenhouse gas sensor, data acquisition ..
  45. Li Y, Min D, Wang K, Yin S, Zheng H, Liu L. MicroRNA‑152 inhibits cell proliferation, migration and invasion by directly targeting MAFB in nasopharyngeal carcinoma. Mol Med Rep. 2017;15:948-956 pubmed publisher
    ..Dual‑luciferase reporter assay was used to determine whether V‑maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) was a direct target gene of miR‑152...
  46. Mitt M, Kals M, Pärn K, Gabriel S, Lander E, Palotie A, et al. Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. Eur J Hum Genet. 2017;25:869-876 pubmed publisher
    ..imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF)?5% and low-frequency variants (0...
  47. Aravind Kumar M, Singh V, Naushad S, Shanker U, Lakshmi Narasu M. Microarray-based SNP genotyping to identify genetic risk factors of triple-negative breast cancer (TNBC) in South Indian population. Mol Cell Biochem. 2018;442:1-10 pubmed publisher
    ..The initial PLINK association analysis (p < 0.01, MAF 0.14-0...
  48. Leavenworth J, Ma X, Mo Y, Pauza M. SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4. J Immunol. 2009;183:1110-9 pubmed publisher
    It is not clear why the development of protective Th2 cells is poor in type 1 diabetes (T1D). c-Maf transactivates the IL-4 gene promoting Th2 cell development; therefore, abnormalities in c-Maf may contribute to reduced IL-4 production ..
  49. Wientjes Y, Veerkamp R, Calus M. Using selection index theory to estimate consistency of multi-locus linkage disequilibrium across populations. BMC Genet. 2015;16:87 pubmed publisher
    ..lower for across population scenarios compared to within population scenarios, and was lower when QTL had a low MAF compared to QTL randomly selected from the SNPs...
  50. Chan C, Munusamy P, Loke S, Koh G, Wong E, Law H, et al. Identification of Novel Breast Cancer Risk Loci. Cancer Res. 2017;77:5428-5437 pubmed publisher
    ..Common coding variants with minor allele frequencies (MAF) >1% that were identified were presumed initially to be SNPs, but further database inspections revealed variants ..
  51. Diop G, Derbois C, Loucoubar C, Mbengue B, Ndao B, Thiam F, et al. Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population. Malar J. 2018;17:61 pubmed publisher
    ..Six frequent SNPs (MAF > 3%) were identified, and one SNP was associated with malaria severity by performing a logistic regression ..
  52. Garziera M, Catamo E, Crovella S, Montico M, Cecchin E, Lonardi S, et al. Association of the HLA-G 3'UTR polymorphisms with colorectal cancer in Italy: a first insight. Int J Immunogenet. 2016;43:32-9 pubmed publisher
    ..3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF = 0.1%) and +3092 G/T (EUR MAF = 0%)...
  53. Verhulst B, Neale M. Minor Allele Frequency Changes the Nature of Genotype by Environment Interactions. Behav Genet. 2016;46:726-733 pubmed publisher
    ..5 if and only if the minor allele frequency (MAF) is ...
  54. Rao D, Gurish M, Marshall J, Slowikowski K, Fonseka C, Liu Y, et al. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017;542:110-114 pubmed publisher
    ..helper' T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF. Like PD-1hiCXCR5+ T follicular helper cells, TPH cells induce plasma cell ..
  55. Dueker N, Guo S, Beecham A, Wang L, Blanton S, Di Tullio M, et al. Sequencing of Linkage Region on Chromosome 12p11 Identifies PKP2 as a Candidate Gene for Left Ventricular Mass in Dominican Families. G3 (Bethesda). 2018;8:659-668 pubmed publisher
    ..Within this region, we tested 5477 common variants [CVs; minor allele frequency (MAF) ?5%] using the Quantitative Transmission-Disequilibrium Test (QTDT)...
  56. Kim H, Lee E, Jung S, Lee J, Chung H, Kim H. Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. J Hum Genet. 2010;55:681-90 pubmed publisher
    ..In a single-SNP-based analysis, the six SNPs in or near genes MAF, MAGI2, BMP4 and PTPN7 showed consistent suggestive associations at all height standard deviation scores using ..
  57. Ahmed S, Mahmood N, Malalla Z, Alsobyani F, Al Kiyumi I, Almawi W. C-reactive protein gene variants associated with recurrent pregnancy loss independent of CRP serum levels: a case-control study. Gene. 2015;569:136-40 pubmed publisher
    ..017). Minor allele frequency (MAF) of rs7553007 was significantly different between RPL cases and control women, and was associated with reduced risk ..
  58. Tanaka H, Muto A, Shima H, Katoh Y, Sax N, Tajima S, et al. Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3. J Biol Chem. 2016;291:6316-30 pubmed publisher
    ..We found that histones H3 and H4 around the Prdm1 intron 5 Maf recognition element were acetylated at higher levels in X63/0 plasma cells expressing Blimp-1 than in BAL17 mature ..
  59. Tang W, Tang J, Zhao Y, Qin Y, Jin G, Xu X, et al. Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease. Mol Neurobiol. 2017;54:1777-1785 pubmed publisher
    ..The exome-wide scan was performed to screen the genetic variants with minor allele frequency (MAF)?<?0.05 in exonic regions...
  60. Chen F, Duggal P, Klein B, Lee K, Truitt B, Klein R, et al. Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent. Mol Vis. 2016;22:783-96 pubmed
    ..80) in the TCTE1 gene region at 6p21.1 (rs2297336, minor allele frequency (MAF) = 14.1%, ? = -0.62 p = 3.7 × 10(-6); rs324146, MAF = 16.9%, ? = -0.55, p = 1.4 × 10(-5))...
  61. Dueker N, Beecham A, Wang L, Blanton S, Guo S, Rundek T, et al. Rare Variants in NOD1 Associated with Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families. PLoS ONE. 2016;11:e0167202 pubmed publisher
    ..Analyses were restricted to single nucleotide variants (SNVs) with population based minor allele frequency (MAF) <5%. We first analyzed all exonic RVs and then the subset of only non-synonymous RVs...
  62. Li Y, Liang G, Shi L, Liang X, Long B, Qin J, et al. Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population. Med Sci Monit. 2016;22:5154-5162 pubmed
    ..190, p=0.001). The minor allele frequency (MAF) of rs662 was significantly higher in the longevity group than in the two control groups...
  63. Tan S, Yip G, Suda T, Baeg G. Small Maf functions in the maintenance of germline stem cells in the Drosophila testis. Redox Biol. 2018;15:125-134 pubmed publisher
    ..We also showed that maf-S is transcriptionally downregulated by oxidative stress, and that maf-S knockdown promotes GSC differentiation but ..
  64. Wang X, Wu J, Jian S, Yang G, Hu B, Wen C. Microcystin induction small Maf protein involve in transcriptional regulation of GST from freshwater mussel Cristaria plicata. Gene. 2018;660:51-61 pubmed publisher
    ..In this study, we tried to identify a small Maf protein in the freshwater mussel Cristaria plicata. The MafK cDNA of C...
  65. Schoeler N, Leu C, White J, Plagnol V, Ellard S, Matarin M, et al. Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy. Epilepsy Res. 2015;118:22-8 pubmed publisher
    ..Case/control association tests were conducted with KCNJ11 and BAD variants with minor allele frequency (MAF)>0.01, using PLINK. Response to KDT in individuals with variants with MAF<0.01 was evaluated...
  66. Noizet M, Lagoutte E, Gratigny M, Bouschbacher M, Lazareth I, Roest Crollius H, et al. Master regulators in primary skin fibroblast fate reprogramming in a human ex vivo model of chronic wounds. Wound Repair Regen. 2016;24:247-62 pubmed publisher
    ..Conversely, down-regulation of MEOX2, SIX2, and MAF causes reprogramming of fibroblasts to myofibroblasts even in absence of TGF-β, the natural inducer of ..
  67. Katsuoka F, Yamamoto M. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 2016;586:197-205 pubmed publisher
    The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription factors...
  68. Bhadra B, Jhung S. A remarkable adsorbent for removal of contaminants of emerging concern from water: Porous carbon derived from metal azolate framework-6. J Hazard Mater. 2017;340:179-188 pubmed publisher
    A series of metal-azolate frameworks or MAFs-MAF-4, -5, and -6-were synthesized and pyrolyzed to prepare porous carbons derived from MAFs (CDM-4, -5, -6, respectively)...
  69. Giordano M, Henin C, Maurizio J, Imbratta C, Bourdely P, Buferne M, et al. Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion. EMBO J. 2015;34:2042-58 pubmed publisher
    ..Among transcriptional regulators, Nr4a2 and Maf were highly overexpressed in tumor-exhausted T cells and significantly upregulated in CD8 T cells from human ..
  70. Matsushita S, Suzuki K, Ogino Y, Hino S, Sato T, Suyama M, et al. Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization. Endocrinology. 2016;157:844-57 pubmed publisher
    ..We have previously shown that v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is an androgen-inducible regulator of embryonic ..
  71. Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, et al. No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome. Int J Hematol. 2016;104:223-7 pubmed publisher
    ..We identified five aHUS patients with PLG:p.Ala620Thr; the minor allele frequency (MAF) was thus 0.024...
  72. Wilkins O, Titus A, Gui J, Eliot M, Butler R, Sturgis E, et al. Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma. Carcinogenesis. 2017;38:986-993 pubmed publisher
    ..We tested the associations of ~40 000 common [minor allele frequency (MAF) ?5%], microRNA-related single nucleotide polymorphisms (miR-SNPs), with risk of head and neck squamous cell ..
  73. Caggiano R, Cattaneo F, Moltedo O, Esposito G, Perrino C, Trimarco B, et al. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Oxid Med Cell Longev. 2017;2017:9308310 pubmed publisher
    MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family...
  74. Woodward O, Köttgen A, Coresh J, Boerwinkle E, Guggino W, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A. 2009;106:10338-42 pubmed publisher
    ..the region and show highly significant associations with urate levels [whites: P = 10(-30), minor allele frequency (MAF) 0.11; blacks P = 10(-4), MAF 0.03] and gout (adjusted odds ratio 1.68 per risk allele, both races)...
  75. Carvajal Yepes M, Himmelsbach K, Schaedler S, Ploen D, Krause J, Ludwig L, et al. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. J Biol Chem. 2011;286:8941-51 pubmed publisher
  76. Katoh Y, Ikura T, Hoshikawa Y, Tashiro S, Ito T, Ohta M, et al. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein. Mol Cell. 2011;41:554-66 pubmed publisher
    ..MATII? was recruited to Maf recognition element (MARE) at HO-1 gene...
  77. Kalsi M, Palli S. Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum. Insect Biochem Mol Biol. 2015;65:47-56 pubmed publisher
    ..regulate P450 gene expression in QTC279 identified cap 'n' collar C (CncC) and muscle aponeurosis fibromatosis (Maf) family transcription factors as the key regulator of these genes, CncC and Maf regulate expression of multiple ..
  78. Olbrot M, Rud J, Moss L, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A. 2002;99:6737-42 pubmed
    ..a biochemical purification approach, we have identified the RIPE3b1 factor as a mammalian homologue of avian MafA/L-Maf (mMafA)...
  79. Chen Y, Cao B, Ou R, Chen X, Zhao B, Wei Q, et al. Association analysis of the GRN  rs5848 and MAPT rs242557 polymorphisms in Parkinson's disease and multiple system atrophy: a large-scale population-based study and meta-analysis. Int J Neurosci. 2016;126:947-54 pubmed publisher
    ..86; 95% CI, 0.76-0.99). No differences in the genotype distributions and minor allele frequency (MAF) of MAPT rs242557 were observed between the PD and the HCs in our Chinese population...
  80. Kos M, Carless M, Peralta J, Blackburn A, Almeida M, Roalf D, et al. Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophr Bull. 2016;42:288-300 pubmed publisher
    ..From the gene SYNPO, rs6579797 (MAF = 0.032) shows significant associations with ABF (P = .015) and schizophrenia (P = .040), as well as jointly (P = ...
  81. HUDDLESTON J, Chaisson M, Steinberg K, Warren W, Hoekzema K, Gordon D, et al. Discovery and genotyping of structural variation from long-read haploid genome sequence data. Genome Res. 2017;27:677-685 pubmed publisher
    ..have been missed as part of analysis of the 1000 Genomes Project even after adjusting for more common variants (MAF > 1%)...
  82. Chen J, Du Y, He X, Huang X, Shi Y. A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse. Sci Rep. 2017;7:517 pubmed publisher
    ..We further verified the efficacy of this novel strategy to target multiple sites by deleting c-Maf and MafB simultaneously in macrophages specifically...
  83. Nho K, Kim S, Horgusluoglu E, Risacher S, Shen L, Kim D, et al. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease. BMC Med Genomics. 2017;10:29 pubmed publisher
    ..We extracted all rare variants (MAF (minor allele frequency) < 0.05) within a 312 kb window in APOE's vicinity encompassing 12 genes...
  84. Broendberg A, Christiansen M, Nielsen J, Pedersen L, Jensen H. Targeted next generation sequencing in a young population with suspected inherited malignant cardiac arrhythmias. Eur J Hum Genet. 2018;26:303-313 pubmed publisher
    ..Seventeen variants were very rare with a minor allele frequency (MAF) ≤0.02% in all population databases used in the study...
  85. Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, et al. Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. Cancer Res. 2017;77:2279-2291 pubmed publisher
    ..Expression of the T-cell transcription factor c-Maf was upregulated in CD4+ T cells primed in tumor-bearing mice in an IL6-dependent manner...
  86. Hendricks A, Bochukova E, Marenne G, Keogh J, Atanassova N, Bounds R, et al. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. Sci Rep. 2017;7:4394 pubmed publisher
    ..The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF~0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells...
  87. Cvekl A, Zhang X. Signaling and Gene Regulatory Networks in Mammalian Lens Development. Trends Genet. 2017;33:677-702 pubmed publisher
    ..Extracellular signaling and DNA-binding transcription factors govern lens and optic cup morphogenesis. Pax6, c-Maf, Hsf4, Prox1, Sox1, and a few additional factors regulate the expression of the lens structural proteins, the ..
  88. Yu J, Hamada M, Ohtsuka S, Yoh K, Takahashi S, Miaw S. Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf. Front Immunol. 2017;8:1399 pubmed publisher
    c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells...
  89. Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, et al. Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. Cancer Res. 2006;66:812-9 pubmed
    c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown...
  90. Gosmain Y, Avril I, Mamin A, Philippe J. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. J Biol Chem. 2007;282:35024-34 pubmed
    ..Although it is known that multiple transcription factors such as Pax-6, Cdx-2/3, c-Maf, Maf-B, and Brain-4 can activate the glucagon gene promoter through G1, their relative importance in vivo is ..
  91. Tanaka T, Ichimura K, Sato Y, Takata K, Morito T, Tamura M, et al. Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis. Pathol Int. 2009;59:804-8 pubmed publisher
  92. Dhiman R, Bandaru A, Barnes P, Saha S, Tvinnereim A, Nayak R, et al. c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages. J Immunol. 2011;186:1638-45 pubmed publisher
    ..tuberculosis H37Rv-stimulated CD14(hi) monocytes produced more IL-10 and had increased mRNA expression for c-Maf, a transcription factor that upregulates IL-10 gene expression...