MAD2L2

Summary

Gene Symbol: MAD2L2
Description: mitotic arrest deficient 2 like 2
Alias: FANCV, MAD2B, POLZ2, REV7, mitotic spindle assembly checkpoint protein MAD2B, MAD2 (mitotic arrest deficient, yeast, homolog)-like 2, MAD2 mitotic arrest deficient-like 2, MAD2-like protein 2, REV7 homolog, hREV7, mitotic arrest deficient 2-like protein 2, mitotic arrest deficient homolog-like 2, polymerase (DNA-directed), zeta 2, accessory subunit
Species: human
Products:     MAD2L2

Top Publications

  1. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce C, et al. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem. 2000;275:4391-7 pubmed
    ..Here we describe a candidate human homolog of S. cerevisiae Rev7 (hREV7), which was identified in a yeast two-hybrid screen using the human homolog of S. cerevisiae Rev3 (hREV3)...
  2. McNally K, Neal J, McManus T, McCormick J, Maher V. hRev7, putative subunit of hPolzeta, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV((254nm))-irradiated human fibroblasts. DNA Repair (Amst). 2008;7:597-604 pubmed publisher
    ..To examine the role of hRev7 in TLS, we generated human fibroblasts expressing hRev7 siRNA, identified two derivative cell strains with ..
  3. Hara K, Hashimoto H, Murakumo Y, Kobayashi S, Kogame T, Unzai S, et al. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem. 2010;285:12299-307 pubmed publisher
    ..REV7 is alternatively called MAD2B or MAD2L2 and also involved in various cellular functions such as signal transduction and cell cycle regulation...
  4. Chen J, Fang G. MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev. 2001;15:1765-70 pubmed
    ..We show here that a MAD2 homolog MAD2B also inhibits APC. In contrast to MAD2, MAD2B inhibits both CDH1-APC and CDC20-APC...
  5. Ying B, Wold W. Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B. Virology. 2003;313:224-34 pubmed
    ..protein that initially was not in the database but has now been published by others with the names human MAD2B, MAD2L2, and REV7...
  6. Okada T, Sonoda E, Yoshimura M, Kawano Y, Saya H, Kohzaki M, et al. Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol. 2005;25:6103-11 pubmed
    In yeast, Rev1, Rev3, and Rev7 are involved in translesion synthesis over various kinds of DNA damage and spontaneous and UV-induced mutagenesis. Here, we disrupted Rev1, Rev3, and Rev7 in the chicken B-lymphocyte line DT40...
  7. Cheung H, Chun A, Wang Q, Deng W, Hu L, Guan X, et al. Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents. Cancer Res. 2006;66:4357-67 pubmed
    ..e., MAD2B) has been identified, which shares significant homology to the mitotic checkpoint protein MAD2...
  8. Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, et al. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007;130:611-23 pubmed
    ..show that the Shigella effector IpaB, when delivered into epithelial cells, causes cell-cycle arrest by targeting Mad2L2, an anaphase-promoting complex/cyclosome (APC) inhibitor...
  9. Pfleger C, Salic A, Lee E, Kirschner M. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 2001;15:1759-64 pubmed
    ..We report a novel means of regulating Cdh1 by the MAD2-related gene, MAD2L2. MAD2L2 specifically binds and inhibits Cdh1-APC, paralleling the effect of MAD2 on Cdc20...

More Information

Publications102 found, 100 shown here

  1. Weterman M, van Groningen J, Tertoolen L, van Kessel A. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. Proc Natl Acad Sci U S A. 2001;98:13808-13 pubmed
    ..We here demonstrate that the mitotic checkpoint protein MAD2B interacts with PRCC...
  2. Li L, Shi Y, Wu H, Wan B, Li P, Zhou L, et al. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem. 2007;304:297-304 pubmed
    ..and progression, we screened a human fetal liver cDNA library and identified a novel HCCA2-interacting protein, MAD2L2 (MAD2 mitotic arrest deficient-like 2 (yeast))...
  3. Medendorp K, van Groningen J, Vreede L, Hetterschijt L, van den Hurk W, de Bruijn D, et al. The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle. PLoS ONE. 2009;4:e7020 pubmed publisher
    Previously, we identified the mitotic arrest deficient protein MAD2B (MAD2L2) as a bona fide interactor of the renal cell carcinoma (RCC)-associated protein PRCC...
  4. Zhang L, Yang S, Sharrocks A. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. Mol Cell Biol. 2007;27:2861-9 pubmed
    ..Here we have identified human Rev7 (hRev7)/MAD2B/MAD2L2 as an interaction partner for Elk-1 and demonstrate that hRev7 acts to promote Elk-1 phosphorylation by the c-Jun ..
  5. Hong C, Chou Y, Lin Y, Wu C. MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. J Biol Chem. 2009;284:19613-22 pubmed publisher
    ..responses, we performed a yeast two-hybrid screen to search for a TCF4-binding protein(s) and found that MAD2B interacts with TCF4. We confirmed that MAD2B is a TCF4-binding protein by co-immunoprecipitation...
  6. Medendorp K, Vreede L, van Groningen J, Hetterschijt L, Brugmans L, Jansen P, et al. The mitotic arrest deficient protein MAD2B interacts with the clathrin light chain A during mitosis. PLoS ONE. 2010;5:e15128 pubmed publisher
    Although the mitotic arrest deficient protein MAD2B (MAD2L2) is thought to inhibit the anaphase promoting complex (APC) by binding to CDC20 and/or CDH1 (FZR1), its exact role in cell cycle control still remains to be established...
  7. Cahill D, da Costa L, Carson Walter E, Kinzler K, Vogelstein B, Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 1999;58:181-7 pubmed
    ..To further explore this issue, we isolated a novel human gene, MAD2B (MAD2L2), which is homologous to the spindle checkpoint gene MAD2 (MAD2L1)...
  8. Chan S, Hung F, Chan D, Shaw P. Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B. Eur J Biochem. 2001;268:2107-12 pubmed
    ..By a yeast two-hybrid system, ribosomal phosphoproteins P0 and P1 and a putative mitotic checkpoint protein, MAD2B, were found to interact with an active-site mutated trichosanthin (TCS)...
  9. Gallego Sánchez A, Andrés S, Conde F, San Segundo P, Bueno A. Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet. 2012;8:e1002826 pubmed publisher
    ..in different ways the interaction of PCNA with DNA polymerase ζ-associated protein Rev1 and with accessory subunit Rev7. While deletion of UBP10 enhances PCNA-Rev1 interaction, it decreases significantly Rev7 binding to the sliding ..
  10. Barazas M, Gasparini A, Huang Y, Küçükosmanoglu A, Annunziato S, Bouwman P, et al. Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors. Cancer Res. 2019;79:452-460 pubmed publisher
    ..drug resistance through restoration of HR activity by the loss of end-resection antagonists of the 53BP1/RIF1/REV7/Shieldin/CST pathway...
  11. Setiaputra D, Durocher D. Shieldin - the protector of DNA ends. EMBO Rep. 2019;: pubmed publisher
    ..Shieldin consists of REV7, a known 53BP1-pathway component, and three hitherto uncharacterized proteins: C20orf196 (SHLD1), FAM35A (SHLD2), ..
  12. Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, et al. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2. Cancer Sci. 2019;110:962-972 pubmed publisher
    ..b>REV7, the structural subunit of eukaryotic DNA polymerase ζ, has multiple functions in bypassing DNA damage and ..
  13. Diniz M, Silva J, de Souza F, Pereira N, Gomes C, Gomez R. Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma. Tumour Biol. 2015;36:9717-22 pubmed publisher
    ..Among these genes, 13 reached statistical significance: ANAPC4, CUL1, SUMO1, KPNA2, MAD2L2, CCNG2, E2F4, NBN, CUL2, PCNA, TFDP1, KNTC1, and ATR. Ki-67 labeling index was similar in both tumor groups...
  14. Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, et al. An OB-fold complex controls the repair pathways for DNA double-strand breaks. Nat Commun. 2018;9:3925 pubmed publisher
    53BP1 with its downstream proteins, RIF1, PTIP and REV7, antagonizes BRCA1-dependent homologous recombination (HR) and promotes non-homologous end joining (NHEJ) in an unclear manner...
  15. Wojtaszek J, Lee C, D Souza S, Minesinger B, Kim H, D Andrea A, et al. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. J Biol Chem. 2012;287:33836-46 pubmed
    ..and with the heterodimeric B-family polymerase ζ, consisting of the catalytic Rev3 subunit and the accessory Rev7 subunit, replacing the insertion polymerase to carry out primer extension past the lesion...
  16. Tomida J, Takata K, Bhetawal S, Person M, Chao H, Tang D, et al. FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells. EMBO J. 2018;37: pubmed publisher
    ..One unsolved problem is the mechanism of regulation of DNA double-strand break repair by REV7 in complex with 53BP1 and RIF1, and its influence on repair pathway choice between homologous recombination and non-..
  17. Vader G. Pch2(TRIP13): controlling cell division through regulation of HORMA domains. Chromosoma. 2015;124:333-9 pubmed publisher
    ..For several of these functions, the Hop1, Rev7, and Mad2 (HORMA) domain-containing proteins Hop1(HORMAD), Mad2, and p31(COMET) are important downstream clients or ..
  18. Barazas M, Annunziato S, Pettitt S, de Krijger I, Ghezraoui H, Roobol S, et al. The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. Cell Rep. 2018;23:2107-2118 pubmed publisher
    ..restoration of BRCA1-independent homologous recombination through loss of factors such as 53BP1, RIF1, and REV7/MAD2L2, which inhibit end resection of DNA double-strand breaks (DSBs)...
  19. Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. 2018;560:112-116 pubmed publisher
    ..When BRCA1 is absent, the resection of double-strand breaks is thought to be prevented by 53BP1, RIF1 and the REV7-SHLD1-SHLD2-SHLD3 (shieldin) complex, and loss of these factors diminishes sensitivity to PARP1 inhibitors4,6-..
  20. Ghezraoui H, Oliveira C, Becker J, Bilham K, Moralli D, Anzilotti C, et al. 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Nature. 2018;560:122-127 pubmed publisher
    ..Here we show that 53BP1 cooperates with its downstream effector protein REV7 to promote non-homologous end joining during class-switch recombination, but REV7 is not required for 53BP1-..
  21. Noordermeer S, Adam S, Setiaputra D, Barazas M, Pettitt S, Ling A, et al. The shieldin complex mediates 53BP1-dependent DNA repair. Nature. 2018;560:117-121 pubmed publisher
    ..interactions with PTIP3 and RIF14-9, the latter of which recruits REV7 (also known as MAD2L2) to break sites10,11...
  22. Findlay S, Heath J, Luo V, Malina A, Morin T, Coulombe Y, et al. SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. EMBO J. 2018;37: pubmed publisher
    ..DNA repair pathway choice is governed by the opposing activities of 53BP1, in complex with its effectors RIF1 and REV7, and BRCA1...
  23. Arbel Eden A, Joseph Strauss D, Masika H, Printzental O, Rachi E, Simchen G. Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis. G3 (Bethesda). 2013;3:633-644 pubmed publisher
    ..We find that the three TLSPs of budding yeast Saccharomyces cerevisiae Rev1, PolZeta (Rev3 and Rev7), and Rad30 are induced during meiosis at a time when DNA double-strand breaks (DSBs) are formed and homologous ..
  24. Pustovalova Y, Magalhães M, D Souza S, Rizzo A, Korza G, Walker G, et al. Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis. Biochemistry. 2016;55:2043-53 pubmed publisher
    ..In the second step, a four-subunit B-family DNA polymerase Polζ (Rev3/Rev7/PolD2/PolD3 complex) extends the distorted DNA primer-template...
  25. Pettitt S, Krastev D, Brandsma I, Dréan A, Song F, Aleksandrov R, et al. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nat Commun. 2018;9:1849 pubmed publisher
    ..to chemotherapeutic drugs compared to other mechanisms of PARPi resistance (BRCA1 reversion, 53BP1, REV7 (MAD2L2) mutation), suggesting that the underlying mechanism of PARPi resistance that emerges could influence the success ..
  26. Rizzo A, Vassel F, Chatterjee N, D Souza S, Li Y, Hao B, et al. Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex. Proc Natl Acad Sci U S A. 2018;115:E8191-E8200 pubmed publisher
    ..Dimerization of HORMA proteins promotes binding and release of this ligand, as exemplified by the Rev7 homolog, Mad2...
  27. Uchiyama M, Terunuma J, Hanaoka F. The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage. PLoS ONE. 2015;10:e0130000 pubmed publisher
    ..In fission yeast, Eso1 (polη), Kpa1/DinB (polκ), Rev1, and Polζ (a complex of Rev3 and Rev7) have been identified as translesion synthesis polymerases...
  28. Suzuki S, Yamamoto H, Oikawa Y, Kondo Kakuta C, Kimura Y, Hirano H, et al. Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation. Proc Natl Acad Sci U S A. 2015;112:3350-5 pubmed publisher
    ..role in the initial step of PAS formation, consists of two structural regions, the N-terminal HORMA (from Hop1, Rev7, and Mad2) domain and the C-terminal disordered region...
  29. Dev H, Chiang T, Lescale C, de Krijger I, Martin A, Pilger D, et al. Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Nat Cell Biol. 2018;20:954-965 pubmed publisher
    ..We establish that Shieldin acts as the downstream effector of 53BP1/RIF1/MAD2L2 to promote DNA double-strand break (DSB) end-joining by restricting DSB resection and to counteract homologous ..
  30. Wang Y, Hao Y, Meng X, He F, Chen S, GAO P, et al. Attenuation of glomerular endothelial cells from high glucose-induced injury by blockade of MAD2B. Cell Physiol Biochem. 2015;35:61-70 pubmed publisher
    To assess the role of mitotic arrest-deficient 2-like protein 2 (MAD2B) in high glucose-induced injury in mouse glomerular endothelial cells (GEnCs)...
  31. Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, et al. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. 2018;173:972-988.e23 pubmed publisher
    ..We identified a novel vertebrate-specific protein complex, shieldin, comprising REV7 plus three previously uncharacterized proteins, RINN1 (CTC-534A2.2), RINN2 (FAM35A), and RINN3 (C20ORF196)...
  32. Pirouz M, Rahjouei A, Shamsi F, Eckermann K, Salinas Riester G, Pommerenke C, et al. Destabilization of pluripotency in the absence of Mad2l2. Cell Cycle. 2015;14:1596-610 pubmed publisher
    ..Here we demonstrate that the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs), ..
  33. Tomida J, Takata K, Lange S, Schibler A, Yousefzadeh M, Bhetawal S, et al. REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ?. Nucleic Acids Res. 2015;43:1000-11 pubmed publisher
    ..REV3L comprises the catalytic subunit, while REV7 (MAD2L2) is considered an accessory subunit...
  34. Makarova A, Burgers P. Eukaryotic DNA polymerase ζ. DNA Repair (Amst). 2015;29:47-55 pubmed publisher
    ..The lagging strand DNA polymerase δ shares the small Pol31 and Pol32 subunits with the Rev3-Rev7 core assembly giving a four subunit Pol ζ complex that is the active form in mutagenesis...
  35. Hatano K, Kumar B, Zhang Y, Coulter J, Hedayati M, Mears B, et al. A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation. Nucleic Acids Res. 2015;43:4075-86 pubmed publisher
    ..miR-890 directly targeted MAD2L2, as well as WEE1 and XPC, where miR-744-3p directly targeted RAD23B...
  36. Jansen J, Tsaalbi Shtylik A, de Wind N. Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease. DNA Repair (Amst). 2015;29:56-64 pubmed publisher
    ..polymerases Rev1 and Pol ζ, the latter consisting of the catalytic subunit Rev3 and the accessory protein Rev7. Here we review the regulation, and the biochemical and cellular functions, of Rev1/Pol ζ-dependent translesion ..
  37. Chromá K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, et al. Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Oncogene. 2017;36:2405-2422 pubmed publisher
    ..Moreover, the overabundant RNF168 and the ensuing unorthodox recruitment patterns of 53BP1, RIF1 and REV7 (monitored on laser micro-irradiation-induced DNA damage) shift the DSB repair balance from HR toward NHEJ, a ..
  38. Rahjouei A, Pirouz M, Di Virgilio M, Kamin D, Kessel M. MAD2L2 Promotes Open Chromatin in Embryonic Stem Cells and Derepresses the Dppa3 Locus. Stem Cell Reports. 2017;8:813-821 pubmed publisher
    ..Here we present evidence for an important epigenetic function of MAD2L2, a protein originally known for its role in DNA damage repair, and for its requirement in germ cell development...
  39. Abbasi A, Khalaj M, Akiyama K, Mukai Y, Matsumoto H, Acosta T, et al. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary. Mol Cell Endocrinol. 2015;412:19-25 pubmed publisher
    b>Rev7 is a subunit of Polζ, one of the translesion DNA synthesis (TLS) polymerases involved in DNA damage repair. We recently found that Rev7 is also essential for germ cell development in mouse...
  40. Meng X, Chu G, Ye C, Tang H, Qiu P, Hu Y, et al. Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells. J Cell Mol Med. 2017;21:1150-1158 pubmed publisher
    Although our recent study has demonstrated that mitotic spindle assembly checkpoint protein (MAD2B) mediates high glucose-induced neuronal apoptosis, the mechanisms for MAD2B degradation under hyperglycaemia have not yet been elucidated...
  41. Bhat A, Wu Z, Maher V, McCormick J, Xiao W. Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle. Cell Cycle. 2015;14:3929-38 pubmed publisher
    ..complex/cyclosome-Cdc20 (APC/C(Cdc20)) inhibitor, has an additional homolog in mammals known as Mad2B, Mad2L2 or Rev7...
  42. Meng X, Chu G, Yang Z, Qiu P, Hu Y, Chen X, et al. Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B. Cell Physiol Biochem. 2016;40:477-485 pubmed
    ..However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in hippocampal and cortical neurons ..
  43. Kurfurstova D, Bartkova J, Vrtel R, Mickova A, Burdova A, Majera D, et al. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. Mol Oncol. 2016;10:879-94 pubmed publisher
    ..sensitizing to PARPi, occurred frequently along with heterogeneous loss of DNA repair factors 53BP1, JMJD1C and Rev7 (all studied here for the first time in CaP) whose defects may cause resistance to PARPi...
  44. Mamrak N, Shimamura A, Howlett N. Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia. Blood Rev. 2017;31:93-99 pubmed publisher
    ..two years, five new FA genes have been identified-RAD51/FANCR, BRCA1/FANCS, UBE2T/FANCT, XRCC2/FANCU, and REV7/FANCV-bringing the total number of disease-causing genes to 21...
  45. Suzuki H, Kaizuka T, Mizushima N, Noda N. Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation. Nat Struct Mol Biol. 2015;22:572-80 pubmed publisher
    ..Here, we report the crystal structure of the fission yeast Atg101-Atg13 complex. Atg101 has a Hop1, Rev7 and Mad2 (HORMA) architecture similar to that of Atg13...
  46. Mumbrekar K, Bola Sadashiva S, Kabekkodu S, Fernandes D, Vadhiraja B, Suga T, et al. Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017;97:118-127 pubmed publisher
    ..22 genetic variants reported in 18 genes (ie, NFE2L2, OGG1, NEIL3, RAD17, PTTG1, REV3L, ALAD, CD44, RAD9A, TGF?R3, MAD2L2, MAP3K7, MAT1A, RPS6KB2, ZNF830, SH3GL1, BAX, and XRCC1) using TaqMan assay-based real-time polymerase chain ..
  47. Mongan A, Lynam Lennon N, Casey R, Maher S, Pidgeon G, Reynolds J, et al. Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma. Clin Transl Oncol. 2016;18:632-40 pubmed publisher
    ..Expression of two spindle assembly complex genes (MAD2L2, BUB1B) was assessed using qPCR, and validated in patient tumour specimens from viscerally obese (n = 46) ..
  48. Li Y, Li L, Chen M, Yu X, Gu Z, Qiu H, et al. MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation. Mol Oncol. 2018;12:391-405 pubmed publisher
    ..We identified mitotic arrest deficient 2-like protein 2 (MAD2L2, also known as MAD2B or REV7), with two signal peptide sequences of LIPLK and EVYPVGIFQK, to be an interaction ..
  49. Pozhidaeva A, Pustovalova Y, D Souza S, Bezsonova I, Walker G, Korzhnev D. NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η. Biochemistry. 2012;51:5506-20 pubmed
    ..Rev1 interaction with the other major human TLS polymerases, polη, ι, κ, and the regulatory subunit Rev7 of polζ, is mediated by Rev1 C-terminal domain (Rev1-CT)...
  50. Qi S, Kim D, Stjepanovic G, Hurley J. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Structure. 2015;23:1848-1857 pubmed publisher
    ..We determined the structure of the complex of the human Atg13 HORMA (Hop1, Rev7, Mad2) domain in complex with the full-length HORMA domain-only protein Atg101...
  51. Okina S, Yanagisawa N, Yokoyama M, Sakurai Y, Numata Y, Umezawa A, et al. High expression of REV7 is an independent prognostic indicator in patients with diffuse large B-cell lymphoma treated with rituximab. Int J Hematol. 2015;102:662-9 pubmed publisher
    b>REV7 is a multifunctional protein involved in DNA damage tolerance, cell-cycle regulation, gene expression, and carcinogenesis...
  52. Bhat A, Qin Z, Wang G, Chen W, Xiao W. Rev7, the regulatory subunit of Polζ, undergoes UV-induced and Cul4-dependent degradation. FEBS J. 2017;284:1790-1803 pubmed publisher
    ..In addition to its role in TLS, mammalian Rev7, also known as Mad2B/Mad2L2, participates in multiple cellular activities including cell cycle progression and double-strand break repair ..
  53. Lee S, Choi B, Yoon C, Kang C, Kim K, Kim K. Selection of biomarkers for HIV-1 latency by integrated analysis. Genomics. 2018;: pubmed publisher
    ..Consequently, we identified nine genes, APBB2, GMPR, IGF2BP3, LRP1, MAD2L2, MX1, OXR1, PTK2B, and TNFSF13B, via integrated analysis...
  54. Tang H, Su H, Fan D, Ye C, Lei C, Jiang H, et al. MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2016;311:F207-16 pubmed publisher
    b>MAD2B, an anaphase-promoting complex/cyclosome (APC/C) inhibitor and a small subunit of DNA polymerase ?, is indispensible for mitotic checkpoint control and DNA repair...
  55. Zimmer J, Tacconi E, Folio C, Badie S, Porru M, Klare K, et al. Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. Mol Cell. 2016;61:449-460 pubmed publisher
    ..PDS toxicity extends to HR-defective cells that have acquired olaparib resistance through loss of 53BP1 or REV7. Altogether, these results highlight the therapeutic potential of G4-stabilizing drugs to selectively eliminate HR-..
  56. Raykov V, Marvin M, Louis E, Maringele L. Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms. Genetics. 2016;203:1659-68 pubmed publisher
    ..This study also uncovered an important role for Rev3 and Rev7 (but not for Pol32) subunits of polymerase ? in the survival of cells undergoing telomere losses and forming ..
  57. Rimkus C, Friederichs J, Rosenberg R, Holzmann B, Siewert J, Janssen K. Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. Int J Cancer. 2007;120:207-11 pubmed
    ..The gene MAD2L2 (mitotic arrest deficient 2-like 2) encodes the spindle checkpoint protein MAD2L2 (or MAD2B), a key component of a ..
  58. Vaclavicek A, Bermejo J, Wappenschmidt B, Meindl A, Sutter C, Schmutzler R, et al. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. Breast Cancer Res Treat. 2007;106:205-13 pubmed
    ..coding single nucleotide polymorphisms (SNPs) in six major spindle checkpoint genes (BUB1B, BUB3, CENPE, MAD2L1, MAD2L2, TTK) on familial breast cancer (BC) risk...
  59. Xu G, Chapman J, Brandsma I, Yuan J, Mistrik M, Bouwman P, et al. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015;521:541-544 pubmed publisher
    ..Here we show that loss of REV7 (also known as MAD2L2) in mouse and human cell lines re-establishes CTIP-dependent end resection of DSBs in BRCA1-deficient cells, ..
  60. Tang H, Fan D, Lei C, Ye C, GAO P, Chen S, et al. MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2. J Mol Med (Berl). 2016;94:1297-1307 pubmed publisher
    The mitotic arrest deficient protein MAD2B is a well-defined anaphase-promoting complex/cyclosome (APC/C) inhibitor and a small subunit of DNA polymerase zeta. It is critical for mitotic control and DNA repair...
  61. Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, et al. H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2. Cell Cycle. 2017;:1-29 pubmed publisher
    ..DNA repair pathway choice depends on inhibition of DNA end-resection by 53BP1 and its downstream factors RIF1 and MAD2L2. However, it is unknown how MAD2L2 accumulates at DSBs to participate in DNA repair pathway control and how the ..
  62. Batenburg N, Walker J, Noordermeer S, Moatti N, Durocher D, Zhu X. ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice. Nat Commun. 2017;8:1921 pubmed publisher
    ..At DSBs, CSB remodels chromatin by evicting histones, which limits RIF1 and its effector MAD2L2 but promotes BRCA1 accumulation...
  63. Nelson K, Schlondorff J, Blobel C. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J. 1999;343 Pt 3:673-80 pubmed
  64. Masuda Y, Ohmae M, Masuda K, Kamiya K. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. J Biol Chem. 2003;278:12356-60 pubmed
    ..It has been suggested that human REV1 interacts with human REV7, this being specific to higher eucaryotes...
  65. Itoh G, Kanno S, Uchida K, Chiba S, Sugino S, Watanabe K, et al. CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J. 2011;30:130-44 pubmed publisher
    ..These data suggest that CAMP is required for maintaining kinetochore-microtubule attachment during bi-orientation. ..
  66. Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H. Structural basis of recruitment of DNA polymerase ? by interaction between REV1 and REV7 proteins. J Biol Chem. 2012;287:33847-52 pubmed
    REV1, REV3, and REV7 are pivotal proteins in translesion DNA synthesis, which allows DNA synthesis even in the presence of DNA damage...
  67. Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
    ..Here we identify MAD2L2 (also known as MAD2B or REV7) through functional genetic screening as a novel factor controlling DNA repair ..
  68. Pinto M, Soares M, Cerveira N, Henrique R, Ribeiro F, Oliveira J, et al. Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes. Virchows Arch. 2007;450:379-85 pubmed
    ..uninhibited by benzimidazole family (BUB1, BUBR1, BUB3) and of the mitotic arrest deficiency family (MAD1, MAD2L1, MAD2L2) by real-time quantitative polymerase chain reaction in 30 renal cell cancer samples (11 chromophobe and 19 ..
  69. Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, et al. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells. Cancer Sci. 2014;105:545-52 pubmed publisher
    Human REV7 (also known as MAD2L2 and MAD2B) is involved in DNA repair, cell cycle regulation, gene transcription, and carcinogenesis...
  70. Howard L, Nelson K, Maciewicz R, Blobel C. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J Biol Chem. 1999;274:31693-9 pubmed
  71. Hanafusa T, Habu T, Tomida J, Ohashi E, Murakumo Y, Ohmori H. Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins. Genes Cells. 2010;15:281-96 pubmed publisher
    ..Here, we have investigated the molecular basis for the interactions of hREV7/MAD2L2 and hMAD2 with their binding partners...
  72. Sharma S, Hicks J, Chute C, Brennan J, Ahn J, Glover T, et al. REV1 and polymerase ? facilitate homologous recombination repair. Nucleic Acids Res. 2012;40:682-91 pubmed publisher
    REV1 and DNA Polymerase ? (REV3 and REV7) play important roles in translesion DNA synthesis (TLS) in which DNA replication bypasses blocking lesions...
  73. Chun A, Kok K, Jin D. REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle. 2013;12:365-78 pubmed publisher
    ..Surprisingly, polyubiquitination of REV1 also requires REV7, a TLS accessory protein that interacts with REV1 and other TLS polymerases...
  74. Actis M, Ambaye N, Evison B, Shao Y, Vanarotti M, Inoue A, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016;24:4339-4346 pubmed publisher
    ..The mammalian DNA polymerase ?, which comprises the catalytic subunit REV3L and the non-catalytic subunit REV7, is essential for ICLR...
  75. Yu N, Song Z, Zhang K, Yang X. MAD2B acts as a negative regulatory partner of TCF4 on proliferation in human dermal papilla cells. Sci Rep. 2017;7:11687 pubmed publisher
    ..In the present study, we identified the mitotic arrest deficient protein MAD2B as a modifier of DPCs...
  76. Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce C, et al. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem. 2001;276:35644-51 pubmed
    ..Human REV7 (hREV7) was also cloned, and its product was found to interact with hREV3, but the biological function of hREV7 remained ..
  77. Hashimoto K, Cho Y, Yang I, Akagi J, Ohashi E, Tateishi S, et al. The vital role of polymerase ? and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ? by REV1 to replication-stalled site. J Biol Chem. 2012;287:9613-22 pubmed publisher
    ..Yeast and mammalian three-hybrid assays revealed that the REV7 subunit of pol ? mediated the interaction between REV3 and the REV1 C terminus...
  78. Meng X, Tian X, Wang X, GAO P, Zhang C. A novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B. Neurogenetics. 2012;13:251-60 pubmed publisher
    ..Using a yeast two-hybrid interaction trap, we identified the mitotic arrest-deficient protein MAD2B as a novel Sim2 binding protein...
  79. Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, et al. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J Biol Chem. 2017;292:17658-17667 pubmed publisher
    Mitotic arrest deficient 2-like protein 2 (MAD2L2), also termed MAD2B or REV7, is involved in multiple cellular functions including translesion DNA synthesis (TLS), signal transduction, transcription, and mitotic events...
  80. Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, et al. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells. 2004;9:523-31 pubmed
    ..The C-terminal region of hREV1 is known to interact with hREV7, a non-catalytic subunit of Polzeta that is another structurally unrelated TLS enzyme, and we show that Polkappa ..
  81. Neal J, Fletcher K, McCormick J, Maher V. The role of hRev7, the accessory subunit of hPol?, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE). BMC Cell Biol. 2010;11:97 pubmed publisher
    ..to play a critical role in DNA damage-induced mutagenesis in human cells, but less is known about the role of hRev7, the accessory subunit of hPol?, in such mutagenesis...
  82. Pustovalova Y, Bezsonova I, Korzhnev D. The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase ? and Rev7 subunit of polymerase ?. FEBS Lett. 2012;586:3051-6 pubmed publisher
    ..domain utilizes independent interaction interfaces to simultaneously bind a fragment of the 'inserter' pol? and Rev7 subunit of the 'extender' pol?, thereby serving as a cassette that may accommodate several polymerases making them ..
  83. Uzunova K, Dye B, Schutz H, Ladurner R, Petzold G, Toyoda Y, et al. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol. 2012;19:1116-23 pubmed publisher
    ..We propose that APC15 and Mnd2 negatively regulate APC/C coactivators and report generation of recombinant human APC/C. ..
  84. Bluteau D, Masliah Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d Enghien C, et al. Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest. 2016;126:3580-4 pubmed publisher
    ..BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E...
  85. Feng L, Wei W, Heng Z, Yantao H, Chunbo W. Knockdown of REV7 Inhibits Breast Cancer Cell Migration and Invasion. Oncol Res. 2016;24:315-325 pubmed
    REV7 (also known as MAD2L2) is a multifunctional protein involved in DNA damage tolerance, cell cycle regulation, gene expression, and carcinogenesis...
  86. Tissier A, Janel Bintz R, Coulon S, Klaile E, Kannouche P, Fuchs R, et al. Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Poleta. DNA Repair (Amst). 2010;9:922-8 pubmed publisher
    ..is able to interact directly not only with Poleta but also with the specialized polymerases Rev1 and Polzeta (via Rev7)...
  87. Pozo F, Oda T, Sekimoto T, Murakumo Y, Masutani C, Hanaoka F, et al. Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. Mol Cell Biol. 2011;31:3396-409 pubmed publisher
    ..These results indicate that Hsp90 promotes folding of REV1 into a stable and/or functional form(s) to bind to monoubiquitinated PCNA. The present findings reveal a novel role of Hsp90 in the regulation of TLS-mediated mutagenesis. ..
  88. Listovsky T, Sale J. Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset. J Cell Biol. 2013;203:87-100 pubmed publisher
    ..Here we show, in human cells, that the APC/C inhibitor MAD2L2 also contributes to ensuring the sequential activation of the APC/C by CDC20 and CDH1...
  89. Su H, Wan Q, Tian X, He F, GAO P, Tang H, et al. MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation. Am J Physiol Renal Physiol. 2015;308:F728-36 pubmed publisher
    ..However, the role of MAD2B, a cell cycle regulator, in podocyte impairment of diabetic nephropathy (DN) is unclear...
  90. Tissier A, Kannouche P, Reck M, Lehmann A, Fuchs R, Cordonnier A. Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein. DNA Repair (Amst). 2004;3:1503-14 pubmed
    ..This hREV1 nuclear localization occurs independently of the presence of hpol eta. Taken together, our data suggest a central role for hREV1 as a scaffold that recruits DNA polymerases involved in TLS. ..
  91. Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H. Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:962-4 pubmed publisher
    REV1, REV3 and REV7 are pivotal proteins in translesion DNA synthesis that allows DNA synthesis to continue even in the presence of DNA damage...