lysyl oxidase


Gene Symbol: lysyl oxidase
Description: lysyl oxidase
Alias: AAT10, protein-lysine 6-oxidase
Species: human
Products:     lysyl oxidase

Top Publications

  1. Bouez C, Reynaud C, Noblesse E, Thépot A, Gleyzal C, Kanitakis J, et al. The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model. Clin Cancer Res. 2006;12:1463-9 pubmed
    b>Lysyl oxidase initiates the enzymatic stage of collagen and elastin cross-linking. Among five isoforms comprising the lysyl oxidase family, LOX is the better studied...
  2. Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol. 2001;70:1-32 pubmed
    b>Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes...
  3. Pez F, Dayan F, Durivault J, Kaniewski B, Aimond G, Le Provost G, et al. The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res. 2011;71:1647-57 pubmed publisher
    ..One critical HIF-1 target mediating tumor progression is lysyl oxidase (LOX), which catalyzes cross-linking of collagens and elastin in the extracellular matrix, thereby regulating ..
  4. Csiszar K, Fong S, Ujfalusi A, Krawetz S, Salvati E, Mackenzie J, et al. Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. Int J Cancer. 2002;97:636-42 pubmed
    b>Lysyl oxidase (LOX), a copper-dependent amine oxidase, has been implicated in tumor suppression and cell growth regulation...
  5. Ji F, Wang Y, Qiu L, Li S, Zhu J, Liang Z, et al. Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer. Int J Oncol. 2013;42:1578-88 pubmed publisher
  6. Schietke R, Warnecke C, Wacker I, Schödel J, Mole D, Campean V, et al. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285:6658-69 pubmed publisher
    ..Gene expression of lysyl oxidase (LOX) and the related LOX-like 2 (LOXL2) is strongly induced by hypoxia...
  7. Barker H, Cox T, Erler J. The rationale for targeting the LOX family in cancer. Nat Rev Cancer. 2012;12:540-52 pubmed publisher
    ..Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles ..
  8. Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, et al. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res. 2004;64:6410-5 pubmed
    b>Lysyl oxidase (LOX) and HRAS-like suppressor (HRASLS) are silenced in human gastric cancers and are reported to have growth-suppressive activities in ras-transformed mouse/rat fibroblasts...
  9. Fogelgren B, Polgar N, Szauter K, Ujfaludi Z, Laczkó R, Fong K, et al. Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation. J Biol Chem. 2005;280:24690-7 pubmed
    b>Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine residues...

More Information


  1. Stewart G, Gray K, Pennington C, Edwards D, Riddick A, Ross J, et al. Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score. Oncol Rep. 2008;20:1561-7 pubmed
    ..Expression of lysyl oxidase (LOX) and glucose transporter-1 (GLUT-1) genes were significantly higher in prostate cancer compared with BPH ..
  2. Yoon J, Park J, Kang Y, Park Y, Nam S, Lee J, et al. Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population. APMIS. 2011;119:762-8 pubmed publisher
    ..0001). Our findings suggest that G473A polymorphism of the LOX gene may be closely associated with susceptibility to the development and differentiation of gastric cancer in South Korean patients. ..
  3. Taylor M, Amin J, Kirschmann D, Schiemann W. Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-? signaling in breast cancer cells. Neoplasia. 2011;13:406-18 pubmed
    ..and tissue compliance promote the acquisition of malignant phenotypes in MECs in part through the activity of lysyl oxidase (LOX), which regulates desmoplastic reactions and metastasis...
  4. Le Q, Harris J, Magliocco A, Kong C, Diaz R, Shin B, et al. Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. J Clin Oncol. 2009;27:4281-6 pubmed publisher
    To validate lysyl oxidase (LOX), a hypoxia-related protein, as a marker for metastasis in an independent head and neck cancer (HNC) patient group enrolled onto a prospective trial...
  5. Erler J, Bennewith K, Cox T, Lang G, Bird D, Koong A, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 2009;15:35-44 pubmed publisher
    ..b>Lysyl oxidase (LOX) is critical for premetastatic niche formation...
  6. Coral K, Angayarkanni N, Madhavan J, Bharathselvi M, Ramakrishnan S, Nandi K, et al. Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment. Invest Ophthalmol Vis Sci. 2008;49:4746-52 pubmed publisher
    b>Lysyl oxidase (LOX) cross-links the side chain of collagen and elastin and thereby contributes to extracellular matrix (ECM) integrity. ECM remodeling is seen in various ocular diseases...
  7. Thomassin L, Werneck C, Broekelmann T, Gleyzal C, Hornstra I, Mecham R, et al. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem. 2005;280:42848-55 pubmed
    These studies were undertaken to determine how lysyl oxidase (LOX) and lysyl oxidase like-1 (LOXL) enzymes are targeted to their substrates in the extracellular matrix...
  8. Liu J, Wei W, Tang W, Jiang Y, Yang H, Li J, et al. Silencing of lysyl oxidase gene expression by RNA interference suppresses metastasis of breast cancer. Asian Pac J Cancer Prev. 2012;13:3507-11 pubmed
    ..LOX displayed an important role in invasion and metastasis of breast cancer by regulating MMP-2 and MMP-9 expression which probably exerted synergistic effects on the extracellular matrix (ECM). ..
  9. Baker A, Cox T, Bird D, Lang G, Murray G, Sun X, et al. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst. 2011;103:407-24 pubmed publisher
    Emerging evidence implicates lysyl oxidase (LOX), an extracellular matrix-modifying enzyme, in promoting metastasis of solid tumors. We investigated whether LOX plays an important role in the metastasis of colorectal cancer (CRC)...
  10. Wu J, Cai C, Tong D, Hou H. Lysyl oxidase G473A polymorphism is associated with increased risk of ovarian cancer. Genet Test Mol Biomarkers. 2012;16:915-9 pubmed publisher
    ..b>Lysyl oxidase (LOX) is an extracellular matrix enzyme that catalyzes the cross-linking of collagens or elastin in the ..
  11. Abourbih D, Di Cesare S, Orellana M, Antecka E, Martins C, Petruccelli L, et al. Lysyl oxidase expression and inhibition in uveal melanoma. Melanoma Res. 2010;20:97-106 pubmed publisher
    b>Lysyl oxidase is a marker of poor prognosis in several malignancies and is hypothesized to promote a migratory phenotype in hypoxic breast carcinomas...
  12. Baker A, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, et al. Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis. Cancer Res. 2013;73:583-94 pubmed publisher
    ..Using multiple models of colorectal cancer, we show that activity of the extracellular matrix-modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothelial cells in vitro and angiogenesis in vivo...
  13. Ren J, Wu X, He W, Shao J, Cheng B, Huang T. Lysyl oxidase 473 G>A polymorphism and breast cancer susceptibility in Chinese Han population. DNA Cell Biol. 2011;30:111-6 pubmed publisher
    b>Lysyl oxidase (LOX) is an extracellular enzyme critical for the cross-linking of collagens and elastin. The LOX gene has also been shown to inhibit the transforming activity of Ras oncogene signaling...
  14. Kagan H, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88:660-72 pubmed
    b>Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these ..
  15. Sakai M, Kato H, Sano A, Tanaka N, Inose T, Kimura H, et al. Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Ann Surg Oncol. 2009;16:2494-501 pubmed publisher
    b>Lysyl oxidase (LOX), an extracellular matrix-remodeling enzyme, has been reported to regulate tumor metastasis. We investigated the clinical significance of LOX expression in esophageal squamous cell carcinoma (ESCC)...
  16. Erler J, Bennewith K, Nicolau M, Dornhöfer N, Kong C, Le Q, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006;440:1222-6 pubmed
    ..Microarray studies have shown the expression of lysyl oxidase (LOX) to be elevated in hypoxic human tumour cells...
  17. Payne S, Fogelgren B, Hess A, Seftor E, Wiley E, Fong S, et al. Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res. 2005;65:11429-36 pubmed
    We have previously shown that lysyl oxidase (LOX) mRNA is up-regulated in invasive breast cancer cells and that catalytically active LOX facilitates in vitro cell invasion...
  18. Sato S, Trackman P, Maki J, Myllyharju J, Kirsch K, Sonenshein G. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol. 2011;31:2683-95 pubmed publisher
    The lysyl oxidase gene (LOX) inhibits Ras signaling in transformed fibroblasts and breast cancer cells. Its activity was mapped to the 162-amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein...
  19. Giampuzzi M, Oleggini R, Di Donato A. Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved. Biochim Biophys Acta. 2003;1647:245-51 pubmed
    b>Lysyl oxidase (LOX) is the enzyme that cross-links extracellular collagen and tropoelastin and is involved in tumor suppressor activity...
  20. Yang X, Li S, Li W, Chen J, Xiao X, Wang Y, et al. Inactivation of lysyl oxidase by ?-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013;29:541-8 pubmed publisher
    ..Tumors under hypoxic conditions are more invasive and have a higher metastasic activity. Lysyl oxidase (LOX) is a hypoxia-responsive gene...
  21. Wiel C, Augert A, Vincent D, Gitenay D, Vindrieux D, Le Calve B, et al. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis. 2013;4:e855 pubmed publisher
    ..We show that lysyl oxidase activity contributes to the decision to maintain senescence...
  22. Shi W, Yang B, Li X, Sun S, Wang L, Jiao S. The effect of lysyl oxidase polymorphism on susceptibility and prognosis of nonsmall cell lung cancer. Tumour Biol. 2012;33:2379-83 pubmed publisher
    b>Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays important roles in development and homeostasis of the lungs...
  23. Rost T, Pyritz V, Rathcke I, Görögh T, Dünne A, Werner J. Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas. Anticancer Res. 2003;23:1565-73 pubmed
    Besides other molecular functions, the lysyl oxidase gene (LOX) has been assumed and shown to have a tumor suppressive function in vitro and in vivo...
  24. Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan H, Baruch Y, et al. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol. 2005;43:499-507 pubmed
    ..The upregulation of Lox and Loxl2 in Wilson's disease could perhaps be utilized for diagnostic purposes since their expression is up-regulated in hepatocytes even before the onset of fibrosis. ..
  25. Wu M, Min C, Wang X, Yu Z, Kirsch K, Trackman P, et al. Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. Cancer Res. 2007;67:6278-85 pubmed
    The gene encoding lysyl oxidase (LOX) was identified as the ras recision gene (rrg), with the ability to revert Ras-mediated transformation of NIH 3T3 fibroblasts...
  26. Zhao Y, Min C, Vora S, Trackman P, Sonenshein G, Kirsch K. The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. J Biol Chem. 2009;284:1385-93 pubmed publisher
    The lysyl oxidase (LOX) gene encodes an enzyme (LOX) critical for extracellular matrix maturation. The LOX gene has also been shown to inhibit the transforming activity of Ras oncogene signaling...
  27. Albinger Hegyi A, Stoeckli S, Schmid S, Storz M, Iotzova G, Probst Hensch N, et al. Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC). Int J Cancer. 2010;126:2653-62 pubmed publisher
    Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression...
  28. Min C, Yu Z, Kirsch K, Zhao Y, Vora S, Trackman P, et al. A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer. Cancer Res. 2009;69:6685-93 pubmed publisher
    The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes...
  29. López B, Gonzalez A, Lindner D, Westermann D, Ravassa S, Beaumont J, et al. Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?. Cardiovasc Res. 2013;99:111-20 pubmed publisher
    ..e. procollagen C-proteinase, PCP) and its cross-linking to form insoluble fibrils (i.e. lysyl oxidase, LOX) in heart failure (HF) of hypertensive origin...
  30. Gayen S, Mandal C, Samanta M, Dey A, Sen S. Expression of an engineered synthetic cry2Aa (D42/K63F/K64P) gene of Bacillus thuringiensis in marker free transgenic tobacco facilitated full-protection from cotton leaf worm (S. littoralis) at very low concentration. World J Microbiol Biotechnol. 2016;32:62 pubmed publisher
    ..Thus, this engineered Cry2Aa toxin could be useful for the generation of insect resistant transgenic Bt lines which will protect the crop damages caused by different insect pests such as CLW and CBW. ..
  31. Shenvi S, Kiran K, Kumar K, Diwakar L, Reddy G. Synthesis and biological evaluation of boswellic acid-NSAID hybrid molecules as anti-inflammatory and anti-arthritic agents. Eur J Med Chem. 2015;98:170-8 pubmed publisher
    ..Hybrid 5 and 9 tested for in-vitro lipoxygenase and cyclooxygenase-2 (LOX/COX-2) inhibitory activity. The studies revealed that both 5 and 9 inhibited COX-2 relatively better than LOX enzyme. ..
  32. Chagas Paula D, Zhang T, da Costa F, Edrada Ebel R. A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition. Metabolites. 2015;5:404-30 pubmed publisher
    ..In addition, the PCA data also gave insights on the chemotaxonomy of the family Asteraceae across its diverse range of genera and tribes. ..
  33. Wu L, Zhu Y. The function and mechanisms of action of LOXL2 in cancer (Review). Int J Mol Med. 2015;36:1200-4 pubmed publisher
    The lysyl oxidase (LOX) family is comprised of five members, and some members have recently emerged as important regulators of tumor progression...
  34. Hashimoto K, Oda Y, Nakamura F, Kakinoki R, Akagi M. Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis. Eur J Histochem. 2017;61:2762 pubmed publisher
    ..The study indicated that the LOX-1/ox-LDL system in chondrocytes plays a role in the pathogenesis of age-related knee OA, which is potentially a target for preventing OA progression. ..
  35. Alam F, Saqib Q, Ashraf M. Gaultheria trichophylla (Royle): a source of minerals and biologically active molecules, its antioxidant and anti-lipoxygenase activities. BMC Complement Altern Med. 2017;17:3 pubmed publisher
    ..The results revealed that this ignored plant has great pharmaceutical and nutraceutical potential. ..
  36. Peperidou A, Bua S, Bozdag M, Hadjipavlou Litina D, Supuran C. Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX. Molecules. 2018;23: pubmed publisher
    ..As hCA IX and LOX are validated antitumor targets, these results are promising for the investigation of novel drug targets involved in tumorigenesis. ..
  37. Yao J, Zou Z, Wang X, Ji X, Yang J. Pinoresinol Diglucoside Alleviates oxLDL-Induced Dysfunction in Human Umbilical Vein Endothelial Cells. Evid Based Complement Alternat Med. 2016;2016:3124519 pubmed publisher
    ..These data demonstrated that PD was effective in protecting endothelial cells from oxLDL-caused injuries, which guarantees further investigation on the clinical benefits of PD on cardiovascular diseases. ..
  38. Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, et al. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017;130:829-831 pubmed publisher
  39. Gioia M, Vindigni G, Testa B, Raniolo S, Fasciglione G, Coletta M, et al. Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells. PLoS ONE. 2015;10:e0141270 pubmed publisher
  40. Chen S, Xu X, Ning L, Jiang W, Xing C, Tang Q, et al. miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase. Obesity (Silver Spring). 2015;23:2445-53 pubmed publisher
    ..Our previous studies have shown that lysyl oxidase (Lox) is upregulated and functions as an essential factor during bone morphogenetic protein 4 (BMP4) -induced ..
  41. Sumayya A, Muraleedhara Kurup G. Biocompatibility of subcutaneously implanted marine macromolecules cross-linked bio-composite scaffold for cartilage tissue engineering applications. J Biomater Sci Polym Ed. 2017;:1-28 pubmed publisher
    ..Taken together, these results demonstrated that HACF biocomposite scaffold signifies its suitability for further research as a scaffold material for cartilage tissue engineering applications...
  42. El Tanbouly G, El Awady M, Megahed N, El Kashef H, Salem H. The lipoxin A4 agonist BML-111 attenuates acute hepatic dysfunction induced by cecal ligation and puncture in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:361-368 pubmed publisher
  43. Abdelrahman M, Youssif B, Abdelgawad M, Abdelazeem A, Ibrahim H, Moustafa A, et al. Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity. Eur J Med Chem. 2017;127:972-985 pubmed publisher
    ..Taken together, these results indicated that these derivatives are good leads for subsequent development into potential anti-inflammatory agents with least gastric damage. ..
  44. Agra N, Cidre F, García García L, de la Parra J, Alonso J. Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells. PLoS ONE. 2013;8:e66281 pubmed publisher
    ..In this study we show that lysyl oxidase (LOX), an enzyme involved in maintaining structural integrity of the extracellular matrix, is downregulated by ..
  45. Xi F, Guo L, Yu Y, Wang Y, Li Q, Zhao H, et al. Comparison of reactive oxygen species metabolism during grape berry development between 'Kyoho' and its early ripening bud mutant 'Fengzao'. Plant Physiol Biochem. 2017;118:634-642 pubmed publisher
    ..Evidence in this study indicated that the overall oxidation status (ROS levels) in 'Fengzao' is higher than in 'Kyoho' and H2O2 could promote the early ripening of 'Kyoho' berry. ..
  46. Deluyker D, Ferferieva V, Noben J, Swennen Q, Bronckaers A, Lambrichts I, et al. Cross-linking versus RAGE: How do high molecular weight advanced glycation products induce cardiac dysfunction?. Int J Cardiol. 2016;210:100-8 pubmed publisher
    ..Plasma levels of glucose, AGEs and soluble RAGE (sRAGE) were measured. AGEs, RAGE and lysyl oxidase (LOX) expression were determined by western blot...
  47. Le Y, Zhu M, Anderson R. Cre Recombinase: You Can't Live with It, and You Can't Live Without It. Adv Exp Med Biol. 2016;854:725-30 pubmed publisher
  48. Xu C, Li D, Wu C, Lou H, Jiang H, Ding G. Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea. Genet Test Mol Biomarkers. 2015;19:272-6 pubmed publisher
    ..Serum sLOX-1 levels were independently correlated with the presence and severity of OSA. These findings revealed that sLOX-1 might function as a potential biomarker for monitoring the development and progression of OSA. ..
  49. Gerstmeier J, Newcomer M, Dennhardt S, Romp E, Fischer J, Werz O, et al. 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation. FASEB J. 2016;30:1892-900 pubmed publisher
    ..Newcomer, M. E., Dennhardt, S., Romp, E., Fischer, J., Werz, O., Garscha, U. 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation. ..
  50. Peng C, Liu J, Yang G, Li Y. Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells. Int J Nanomedicine. 2018;13:161-174 pubmed publisher
    ..Multispectral analyses were performed for quantifying stromal biomarkers, such as lysyl oxidase (LOX)...
  51. Soldo B, Sprung M, Mušac G, Pavela Vrancic M, Ljubenkov I. Evaluation of Olive Fruit Lipoxygenase Extraction Protocols on 9- and 13-Z,E-HPODE Formation. Molecules. 2016;21:506 pubmed publisher
    ..Future research concerning olive LOX should employ extraction methods that preserve enzyme activity. ..
  52. Nagelreiter I, Parvardeh M, Narzt M, Beer L, Kremslehner C, Muresan X, et al. OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes. Mech Ageing Dev. 2018;172:35-44 pubmed publisher
    ..We identify sebocytes as cutaneous cells responsive to lipid mediated redox stress which is not dependent on the scavenger receptor OLR1. ..
  53. Palit P, Mandal S, Bhunia B. Total steroid and terpenoid enriched fraction from Euphorbia neriifolia Linn offers protection against nociceptive-pain, inflammation, and in vitro arthritis model: An insight of mechanistic study. Int Immunopharmacol. 2016;41:106-115 pubmed publisher
    ..Our findings suggest that STF-HAENS could be used as an effective safe therapeutic agent for treatment of nociceptive pain, acute inflammation and arthritis. ..
  54. Pérez Calderón J, Califano A, Santos M, Zaritzky N. Kinetic Parameters for the Thermal Inactivation of Peroxidase and Lipoxygenase in Precooked Frozen Brassica Species. J Food Sci. 2017;82:1378-1386 pubmed publisher
    ..A sensory analysis confirmed the global acceptability of the product. The obtained results are relevant to define the precooking stage conditions in the production of frozen cruciferous vegetables...
  55. Yoneyama T, Kasuya H, Onda H, Akagawa H, Jinnai N, Nakajima T, et al. Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. J Hum Genet. 2003;48:309-14 pubmed
    ..we focus on 5q31, where three candidate genes, fibroblast growth factor 1 (FGF1), fibrillin 2 (FBN2), and lysyl oxidase gene ( LOX) lie, and evaluate associations with IA...
  56. Choudhury R, McGovern A, Ridley C, Cain S, Baldwin A, Wang M, et al. Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem. 2009;284:24553-67 pubmed publisher
    ..We have determined how they interact with tropoelastin, lysyl oxidase, and fibrillin-1, thereby revealing how they differentially regulate assembly...
  57. Hofmann A, Brunssen C, Poitz D, Langbein H, Strasser R, Henle T, et al. Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background. Atheroscler Suppl. 2017;30:294-302 pubmed publisher
    ..Endothelial LOX-1 overexpression in an atherosclerosis-prone background impairs endothelial function, proving its importance in the development of atherosclerosis. ..
  58. Prasanth S, Haridas K, Haridas M, Sabu A. Novel lipoxygenase inhibitor, 1-ethenoxy-2-methylbenzene, from marine cyanobacteria Microcoleus chthonoplastes. Nat Prod Res. 2017;:1-6 pubmed publisher
    ..Its high structure-activity resemblance to cuminaldehyde from cumin seeds, which is earlier reported as a LOX inhibitor, is also established...
  59. Nègre Salvayre A, Augé N, Camaré C, Bacchetti T, Ferretti G, Salvayre R. Dual signaling evoked by oxidized LDLs in vascular cells. Free Radic Biol Med. 2017;106:118-133 pubmed publisher
    ..Finally, these dual properties suggest that oxLDLs could be implicated at each step of atherosclerosis development, from early fatty streaks to advanced lesions, depending on the nature and concentration of their oxidized lipid content. ..
  60. Lai H, Jin Q, Lin Y, Mo X, Li B, He K, et al. Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer. Tumour Biol. 2014;35:10547-54 pubmed publisher
    The purpose of this study was to determine whether lysyl oxidase (LOX) is a useful marker of metastasis in gastric cancer (GC) patients in combination with tumor markers carcino-embryonic antigen (CEA), carbohydrate antigen 724 (CA724), ..
  61. Zhang J, Zhang L, Hong J, Wu D, Xu J. Association of Common Variants in LOX with Keratoconus: A Meta-Analysis. PLoS ONE. 2015;10:e0145815 pubmed publisher
    Several case-control studies have been performed to examine the association of genetic variants in lysyl oxidase (LOX) with keratoconus. However, the results remained inconclusive and great heterogeneity might exist across populations...
  62. Mouchlis V, Morisseau C, Hammock B, Li S, McCammon J, Dennis E. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016;24:4801-4811 pubmed publisher
    ..This work constitutes the foundation for further design, synthesis and inhibition studies in order to develop new beta-thioether analogues that are potent and selective for GVIA iPLA2 exclusively. ..
  63. Wang Y, Ma J, Shen H, Wang C, Sun Y, Howell S, et al. Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway. Oncol Rep. 2014;32:2150-8 pubmed publisher ovarian carcinoma cells upregulated HIF-1α expression and subsequent transcriptional induction of lysyl oxidase (LOX) which repressed E-cadherin...
  64. Kalamajski S, Bihan D, Bonna A, Rubin K, Farndale R. Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase. J Biol Chem. 2016;291:7951-60 pubmed publisher
    ..disorders is a highly cross-linked and dense collagen matrix, a property driven by the oxidative action of lysyl oxidase. Other fibrosis-associated proteins also contribute to the final collagen matrix properties, one of which is ..
  65. Hamalainen E, Jones T, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko K. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. Genomics. 1991;11:508-16 pubmed
    b>Lysyl oxidase (EC initiates the crosslinking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues...
  66. Teng L, Han W, Fan X, Xu D, Zhang X, Dittami S, et al. Evolution and Expansion of the Prokaryote-Like Lipoxygenase Family in the Brown Alga Saccharina japonica. Front Plant Sci. 2017;8:2018 pubmed publisher
  67. Chen J, Ren J, Loo W, Hao L, Wang M. Lysyl oxidases expression and histopathological changes of the diabetic rat nephron. Mol Med Rep. 2017;: pubmed publisher
    ..The expression of LOX and lysyl oxidase?like 1 to 3 (LOXL1 to 3) levels were evaluated by immunohistochemical staining...
  68. Myamoto D, Pidde Queiroz G, Pedroso A, Gonçalves de Andrade R, van den Berg C, Tambourgi D. Characterization of the gene encoding component C3 of the complement system from the spider Loxosceles laeta venom glands: Phylogenetic implications. Immunobiology. 2016;221:953-63 pubmed publisher
    ..This work will help to improve our understanding of the innate immune system in these spiders and the ancestral structure of C3. ..
  69. Chistiakov D, Melnichenko A, Myasoedova V, Grechko A, Orekhov A. Mechanisms of foam cell formation in atherosclerosis. J Mol Med (Berl). 2017;95:1153-1165 pubmed publisher
    ..Moreover, other cell types, such as endothelial (ECs) and vascular smooth muscle cells (VSMCs), can also become foam cells. In this review, we discuss known pathways of foam cell formation in atherosclerosis. ..
  70. Adili R, Tourdot B, Mast K, Yeung J, Freedman J, Green A, et al. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arterioscler Thromb Vasc Biol. 2017;37:1828-1839 pubmed publisher
    ..Our data strongly support 12-LOX as a key determinant of platelet reactivity in vivo, and inhibition of platelet 12-LOX with ML355 may represent a new class of antiplatelet therapy. ..
  71. Wilhelmus M, Bol J, van Duinen S, Drukarch B. Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type. Exp Gerontol. 2013;48:109-14 pubmed publisher
    ..b>Lysyl oxidase (LOX, E.C. 1.4.3...
  72. Chekuru A, Kuscha V, Hans S, Brand M. Ligand-Controlled Site-Specific Recombination in Zebrafish. Methods Mol Biol. 2017;1642:87-97 pubmed publisher
    ..In addition, we introduce detailed protocols to elicit CreERT2-mediated recombination in vivo at embryonic as well as adult stages. ..
  73. Dogan I, Dogan T, Yetim M, Kayadibi H, Yilmaz M, Eser B, et al. Relation of Serum ADMA, Apelin-13 and LOX-1 Levels with Inflammatory and Echocardiographic Parameters in Hemodialysis Patients. Ther Apher Dial. 2017;: pubmed publisher
    ..Serum ADMA, Apelin-13, and LOX-1 levels can be indicators not only for the inflammatory process but also for the pathogenesis of cardiovascular diseases in hemodialysis patients...
  74. Zhang H, Zhao K, Xu Y, Hong B, Zhao W, Liu J, et al. Lysyl oxidase polymorphisms and ischemic stroke--a case control study. Mol Biol Rep. 2012;39:9391-7 pubmed publisher
    Ischemic stroke is a common neurological disease and causes severe disability and death worldwide. Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability and may participate in vascular remodeling ..
  75. Babenko L, Shcherbatiuk M, Skaterna T, Kosakivska I. Lipoxygenases and their metabolites in formation of plant stress tolerance. Ukr Biochem J. 2017;89:5-21 pubmed publisher
    ..Some results of our studies that open up possibilities of using the lipoxygenase catalytic activity characteristics as biological markers in plant stress tolerance researches are given. ..
  76. Nilsson G, Kannius Janson M. Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling. BMC Cancer. 2016;16:142 pubmed publisher
    ..The extracellular matrix enzyme lysyl oxidase (LOX) was negatively regulated by NFI-C2 and positively regulated by FoxF1, and upregulation of LOX following ..